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Conserved domains on  [gi|1176777471|gb|OQY95347|]
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MAG: arylsulfatase, partial [Anaerolineae bacterium UTCFX2]

Protein Classification

alkaline phosphatase family protein( domain architecture ID 581061)

alkaline phosphatase (ALP) family protein may catalyze the hydrolysis of substrates; the ALP superfamily includes alkaline phosphatases and sulfatases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ALP_like super family cl23718
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ...
 1-206 2.14e-96

alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.


The actual alignment was detected with superfamily member cd16142:

Pssm-ID: 474031 [Multi-domain]  Cd Length: 372  Bit Score: 287.12  E-value: 2.14e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   1 WQSFYHDVMVEHDKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMNTWPDGAMTPFRNEKNSNWEGAFRVPEMVRWPGKIP 80
Cdd:cd16142   178 GKGKYADSMVELDDHVGQILDALDELGIADNTIVIFTTDNGPEQDVWPDGGYTPFRGEKGTTWEGGVRVPAIVRWPGKIK 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  81 AGVVSNEIISHTDWLPTLLAAAGDAEISEKLkkgykagdKTFKVHIDGYNFLPYLTGQVEKGPRqGIIYFSDDGDLVGLR 160
Cdd:cd16142   258 PGRVSNEIVSHLDWFPTLAALAGAPDPKDKL--------LGKDRHIDGVDQSPFLLGKSEKSRR-SEFFYFGEGELGAVR 328

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1176777471 161 YDNWKFVFAEQRVPGTvmIWAEPFVFLRVPKIFNLRTDPFERADIT 206
Cdd:cd16142   329 WKNWKVHFKAQEDTGG--PTGEPFYVLTFPLIFNLRRDPKERYDVT 372
 
Name Accession Description Interval E-value
ARS_like cd16142
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ...
 1-206 2.14e-96

uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293761 [Multi-domain]  Cd Length: 372  Bit Score: 287.12  E-value: 2.14e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   1 WQSFYHDVMVEHDKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMNTWPDGAMTPFRNEKNSNWEGAFRVPEMVRWPGKIP 80
Cdd:cd16142   178 GKGKYADSMVELDDHVGQILDALDELGIADNTIVIFTTDNGPEQDVWPDGGYTPFRGEKGTTWEGGVRVPAIVRWPGKIK 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  81 AGVVSNEIISHTDWLPTLLAAAGDAEISEKLkkgykagdKTFKVHIDGYNFLPYLTGQVEKGPRqGIIYFSDDGDLVGLR 160
Cdd:cd16142   258 PGRVSNEIVSHLDWFPTLAALAGAPDPKDKL--------LGKDRHIDGVDQSPFLLGKSEKSRR-SEFFYFGEGELGAVR 328

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1176777471 161 YDNWKFVFAEQRVPGTvmIWAEPFVFLRVPKIFNLRTDPFERADIT 206
Cdd:cd16142   329 WKNWKVHFKAQEDTGG--PTGEPFYVLTFPLIFNLRRDPKERYDVT 372
AslA COG3119
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
5-208 9.18e-54

Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 442353 [Multi-domain]  Cd Length: 393  Bit Score: 178.53  E-value: 9.18e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   5 YHDVMVEHDKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMNTWPdgamtpFRNEKNSNWEGAFRVPEMVRWPGKIPAGVV 84
Cdd:COG3119   202 YAAMIEEVDDQVGRLLDALEELGLADNTIVVFTSDNGPSLGEHG------LRGGKGTLYEGGIRVPLIVRWPGKIKAGSV 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  85 SNEIISHTDWLPTLLAAAGdAEISEklkkgykagdktfkvHIDGYNFLPYLTGQVEKGPRQGIIYFSDDGDLVGLRYDNW 164
Cdd:COG3119   276 SDALVSLIDLLPTLLDLAG-VPIPE---------------DLDGRSLLPLLTGEKAEWRDYLYWEYPRGGGNRAIRTGRW 339

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1176777471 165 KFVFAEQRVPgtvmiwaepfvflrVPKIFNLRTDPFERADITSN 208
Cdd:COG3119   340 KLIRYYDDDG--------------PWELYDLKNDPGETNNLAAD 369
Sulfatase pfam00884
Sulfatase;
13-103 2.37e-20

Sulfatase;


Pssm-ID: 459979 [Multi-domain]  Cd Length: 298  Bit Score: 87.86  E-value: 2.37e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  13 DKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMntwpDGAMTPFRNEK-NSNWEGAFRVPEMVRWPGKIPAGVVSNEIISH 91
Cdd:pfam00884 210 DDAIGRVLDKLEENGLLDNTLVVYTSDHGESL----GEGGGYLHGGKyDNAPEGGYRVPLLIWSPGGKAKGQKSEALVSH 285

                          90
                  ....*....|..
gi 1176777471  92 TDWLPTLLAAAG 103
Cdd:pfam00884 286 VDLFPTILDLAG 297
PRK13759 PRK13759
arylsulfatase; Provisional
 5-154 3.45e-09

arylsulfatase; Provisional


Pssm-ID: 237491 [Multi-domain]  Cd Length: 485  Bit Score: 56.60  E-value: 3.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   5 YHDVMVEHDKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMntwpdGAMTPFRneKNSNWEGAFRVPEMVRWPG---KIPA 81
Cdd:PRK13759  270 YYGLITHIDHQIGRFLQALKEFGLLDNTIILFVSDHGDML-----GDHYLFR--KGYPYEGSAHIPFIIYDPGgllAGNR 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  82 GVVSNEIISHTDWLPTLLAAAG-------DAEISEKLKKGYKAGDKTF--KVHIDGYNFLPYLTGQVEKgprqgIIYFSD 152
Cdd:PRK13759  343 GTVIDQVVELRDIMPTLLDLAGgtipddvDGRSLKNLIFGQYEGWRPYlhGEHALGYSSDNYLTDGKWK-----YIWFSQ 417


                  ..
gi 1176777471 153 DG 154
Cdd:PRK13759  418 TG 419
 
Name Accession Description Interval E-value
ARS_like cd16142
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ...
 1-206 2.14e-96

uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293761 [Multi-domain]  Cd Length: 372  Bit Score: 287.12  E-value: 2.14e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   1 WQSFYHDVMVEHDKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMNTWPDGAMTPFRNEKNSNWEGAFRVPEMVRWPGKIP 80
Cdd:cd16142   178 GKGKYADSMVELDDHVGQILDALDELGIADNTIVIFTTDNGPEQDVWPDGGYTPFRGEKGTTWEGGVRVPAIVRWPGKIK 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  81 AGVVSNEIISHTDWLPTLLAAAGDAEISEKLkkgykagdKTFKVHIDGYNFLPYLTGQVEKGPRqGIIYFSDDGDLVGLR 160
Cdd:cd16142   258 PGRVSNEIVSHLDWFPTLAALAGAPDPKDKL--------LGKDRHIDGVDQSPFLLGKSEKSRR-SEFFYFGEGELGAVR 328

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1176777471 161 YDNWKFVFAEQRVPGTvmIWAEPFVFLRVPKIFNLRTDPFERADIT 206
Cdd:cd16142   329 WKNWKVHFKAQEDTGG--PTGEPFYVLTFPLIFNLRRDPKERYDVT 372
AslA COG3119
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
5-208 9.18e-54

Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 442353 [Multi-domain]  Cd Length: 393  Bit Score: 178.53  E-value: 9.18e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   5 YHDVMVEHDKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMNTWPdgamtpFRNEKNSNWEGAFRVPEMVRWPGKIPAGVV 84
Cdd:COG3119   202 YAAMIEEVDDQVGRLLDALEELGLADNTIVVFTSDNGPSLGEHG------LRGGKGTLYEGGIRVPLIVRWPGKIKAGSV 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  85 SNEIISHTDWLPTLLAAAGdAEISEklkkgykagdktfkvHIDGYNFLPYLTGQVEKGPRQGIIYFSDDGDLVGLRYDNW 164
Cdd:COG3119   276 SDALVSLIDLLPTLLDLAG-VPIPE---------------DLDGRSLLPLLTGEKAEWRDYLYWEYPRGGGNRAIRTGRW 339

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1176777471 165 KFVFAEQRVPgtvmiwaepfvflrVPKIFNLRTDPFERADITSN 208
Cdd:COG3119   340 KLIRYYDDDG--------------PWELYDLKNDPGETNNLAAD 369
GALNS_like cd16026
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ...
 5-206 2.57e-50

galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.


Pssm-ID: 293750 [Multi-domain]  Cd Length: 399  Bit Score: 169.67  E-value: 2.57e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   5 YHDVMVEHDKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMNTWPDGAMT-PFRNEKNSNWEGAFRVPEMVRWPGKIPAGV 83
Cdd:cd16026   213 YGDVVEELDWSVGRILDALKELGLEENTLVIFTSDNGPWLEYGGHGGSAgPLRGGKGTTWEGGVRVPFIAWWPGVIPAGT 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  84 VSNEIISHTDWLPTLLAAAGdAEISEKLKkgykagdktfkvhIDGYNFLPYLTGQvEKGPRQGIIYFSDDGDLVGLRYDN 163
Cdd:cd16026   293 VSDELASTMDLLPTLAALAG-APLPEDRV-------------IDGKDISPLLLGG-SKSPPHPFFYYYDGGDLQAVRSGR 357

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1176777471 164 WKFVFAEQRVPGTvMIWAEPFVFLRVPKIFNLRTDPFERADIT 206
Cdd:cd16026   358 WKLHLPTTYRTGT-DPGGLDPTKLEPPLLYDLEEDPGETYNVA 399
ARS_like cd16145
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ...
 9-205 2.26e-43

uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293764 [Multi-domain]  Cd Length: 415  Bit Score: 151.98  E-value: 2.26e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   9 MVEH-DKHVGQLLDLLDELGIAEDTIVMYSTDNGPHM-------NTWPDGAmTPFRNEKNSNWEGAFRVPEMVRWPGKIP 80
Cdd:cd16145   236 MVTRlDRDVGRILALLKELGIDENTLVVFTSDNGPHSeggsehdPDFFDSN-GPLRGYKRSLYEGGIRVPFIARWPGKIP 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  81 AGVVSNEIISHTDWLPTLLAAAGdaeiseklkkgykagdKTFKVHIDGYNFLPYLTGQVEKGPRQGIIY-FSDDGDLVGL 159
Cdd:cd16145   315 AGSVSDHPSAFWDFMPTLADLAG----------------AEPPEDIDGISLLPTLLGKPQQQQHDYLYWeFYEGGGAQAV 378

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1176777471 160 RYDNWKFVfaeqRVPGtvmiWAEPFvflrvpKIFNLRTDPFERADI 205
Cdd:cd16145   379 RMGGWKAV----RHGK----KDGPF------ELYDLSTDPGETNNL 410
ARS_like cd16143
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ...
 5-205 2.95e-40

uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293762 [Multi-domain]  Cd Length: 395  Bit Score: 143.11  E-value: 2.95e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   5 YHDVMVEHDKHVGQLLDLLDELGIAEDTIVMYSTDNGP----------HMNTWPDGamtPFRNEKNSNWEGAFRVPEMVR 74
Cdd:cd16143   203 YGDFVYELDWVVGRILDALKELGLAENTLVIFTSDNGPspyadykeleKFGHDPSG---PLRGMKADIYEGGHRVPFIVR 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  75 WPGKIPAGVVSNEIISHTDWLPTLLAAAGdaeisEKLKKGykagdktfkVHIDGYNFLPYLTGQVEKGPRQGIIYFSDDG 154
Cdd:cd16143   280 WPGKIPAGSVSDQLVSLTDLFATLAAIVG-----QKLPDN---------AAEDSFSFLPALLGPKKQEVRESLVHHSGNG 345

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1176777471 155 DLvGLRYDNWKFVFAeqrvpGTVMIWAEPFVFLRVPK----IFNLRTDPFERADI 205
Cdd:cd16143   346 SF-AIRKGDWKLIDG-----TGSGGFSYPRGKEKLGLppgqLYNLSTDPGESNNL 394
ARS_like cd16144
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ...
 9-205 1.46e-38

uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293763 [Multi-domain]  Cd Length: 421  Bit Score: 139.22  E-value: 1.46e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   9 MVEH-DKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMNTWPDGA-MTPFRNEKNSNWEGAFRVPEMVRWPGKIPAGVVSN 86
Cdd:cd16144   228 MIESlDESVGRILDALEELGLADNTLVIFTSDNGGLSTRGGPPTsNAPLRGGKGSLYEGGIRVPLIVRWPGVIKPGSVSD 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  87 EIISHTDWLPTLLAAAGDAEISEKlkkgykagdktfkvHIDGYNFLPYLTGQVEKGPRQGII----YFSDDGDLVG--LR 160
Cdd:cd16144   308 VPVIGTDLYPTFLELAGGPLPPPQ--------------HLDGVSLVPLLKGGEADLPRRALFwhfpHYHGQGGRPAsaIR 373

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1176777471 161 YDNWKFV--FAEQRVpgtvmiwaepfvflrvpKIFNLRTDPFERADI 205
Cdd:cd16144   374 KGDWKLIefYEDGRV-----------------ELYNLKNDIGETNNL 403
ARS_like cd16146
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide ...
 9-207 2.78e-37

uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293765 [Multi-domain]  Cd Length: 409  Bit Score: 135.37  E-value: 2.78e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   9 MVEH-DKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMnTWPDGAMTPFRNEKNSNWEGAFRVPEMVRWPGKIPAGVVSNE 87
Cdd:cd16146   213 MIENiDDNVGRLLAKLKELGLEENTIVIFMSDNGPAG-GVPKRFNAGMRGKKGSVYEGGHRVPFFIRWPGKILAGKDVDT 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  88 IISHTDWLPTLLAAAGdAEISEKLKkgykagdktfkvhIDGYNFLPYLTGQVEKGPRQGIIYFSDDGDLVGLRYDNWKFV 167
Cdd:cd16146   292 LTAHIDLLPTLLDLCG-VKLPEGIK-------------LDGRSLLPLLKGESDPWPERTLFTHSGRWPPPPKKKRNAAVR 357

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1176777471 168 FAEQRvpgtvMIWAEPFvflrVPKIFNLRTDPFERADITS 207
Cdd:cd16146   358 TGRWR-----LVSPKGF----QPELYDIENDPGEENDVAD 388
sulfatase_like cd16022
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, ...
 9-111 1.86e-33

sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293746 [Multi-domain]  Cd Length: 236  Bit Score: 121.39  E-value: 1.86e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   9 MVEH-DKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMNtwpDGAMtpfRNEKNSNWEGAFRVPEMVRWPGKIPAGVVSNE 87
Cdd:cd16022   136 MVSAiDDQIGRILDALEELGLLDNTLIVFTSDHGDMLG---DHGL---RGKKGSLYEGGIRVPFIVRWPGKIPAGQVSDA 209

                          90       100
                  ....*....|....*....|....
gi 1176777471  88 IISHTDWLPTLLAAAGdAEISEKL 111
Cdd:cd16022   210 LVSLLDLLPTLLDLAG-IEPPEGL 232
ES cd16159
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of ...
 5-213 1.72e-28

Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of the active estrogen in tumor cells. ES catalyzes the hydrolysis of E1 sulfate, which is a component of the three-enzyme system that has been implicated in intracrine biosynthesis of estradiol. It is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES consisting of two antiparallel alpha helices that protrude from the roughly spherical molecule. These highly hydrophobic helices anchor the functional domain on the membrane surface facing the ER lumen.


Pssm-ID: 293778 [Multi-domain]  Cd Length: 521  Bit Score: 113.15  E-value: 1.72e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   5 YHDVMVEHDKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMNTWPDGAMTP------FRNEKNSNWEGAFRVPEMVRWPGK 78
Cdd:cd16159   281 YGDNVEEMDWSVGQILDALDELGLKDNTFVYFTSDNGGHLEEISVGGEYGggnggiYGGKKMGGWEGGIRVPTIVRWPGV 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  79 IPAGVVSNEIISHTDWLPTLLAAAGdAEISEklkkgykagDKtfkvHIDGYNFLPYLTGQVEKGPRQ-----------GI 147
Cdd:cd16159   361 IPPGSVIDEPTSLMDIFPTVAALAG-APLPS---------DR----IIDGRDLMPLLTGQEKRSPHEflfhycgaelhAV 426

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1176777471 148 IYFSDDGDLVglrydnWKFVFAE-QRVPGTVMiWAEPFVF---------LRVPKIFNLRTDPFERA--DITSNTYWDW 213
Cdd:cd16159   427 RYRPRDGGAV------WKAHYFTpNFYPGTEG-CCGTLLCrcfgdsvthHDPPLLFDLSADPSESNplDPTDEPYQEI 497
PAS_like cd16025
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze ...
 9-205 3.33e-27

Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293749 [Multi-domain]  Cd Length: 402  Bit Score: 108.30  E-value: 3.33e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   9 MVEH-DKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMNT-WPDGAMTPFRNEKNSNWEGAFRVPEMVRWPGKIPA-GVVS 85
Cdd:cd16025   224 MVEHmDQQIGRLIDYLKELGELDNTLIIFLSDNGASAEPgWANASNTPFRLYKQASHEGGIRTPLIVSWPKGIKAkGGIR 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  86 NEIISHTDWLPTLLAAAGdAEISEKLKKGykagdktfKVH-IDGYNFLPYLTGQVEKGPRQgIIYFsddgDLVG---LRY 161
Cdd:cd16025   304 HQFAHVIDIAPTILELAG-VEYPKTVNGV--------PQLpLDGVSLLPTLDGAAAPSRRR-TQYF----ELFGnraIRK 369

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1176777471 162 DNWKFVfAEQRVPGTVMIWAepfvflrvpkIFNLRTDPFERADI 205
Cdd:cd16025   370 GGWKAV-ALHPPPGWGDQWE----------LYDLAKDPSETHDL 402
4-S cd16029
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the ...
 9-205 6.79e-26

N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the hydrolysis of sulfuric acid esters from a wide variety of substrates. N-acetylgalactosamine 4-sulfatase catalyzes the removal of the sulfate ester group from position 4 of an N-acetylgalactosamine sugar at the non-reducing terminus of the polysaccharide in the degradative pathways of the glycosaminoglycans dermatan sulfate and chondroitin-4-sulfate. N-acetylgalactosamine 4-sulfatase is a lysosomal enzyme.


Pssm-ID: 293753 [Multi-domain]  Cd Length: 393  Bit Score: 104.55  E-value: 6.79e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   9 MVEH-DKHVGQLLDLLDELGIAEDTIVMYSTDNG-PHM-----NTWPdgamtpFRNEKNSNWEGAFRVPEMVRWPG-KIP 80
Cdd:cd16029   225 MVSAlDESVGNVVDALKAKGMLDNTLIVFTSDNGgPTGggdggSNYP------LRGGKNTLWEGGVRVPAFVWSPLlPPK 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  81 AGVVSNEIISHTDWLPTLLAAAGdaeiseklkkgykaGDKTFKVHIDGYNFLPYLTGQvEKGPRQGIIY----FSDDGDL 156
Cdd:cd16029   299 RGTVSDGLMHVTDWLPTLLSLAG--------------GDPDDLPPLDGVDQWDALSGG-APSPRTEILLniddITRTTGG 363

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1176777471 157 VGLRYDNWKFVFAEQrvpgtvmiwaepfvflrvpkIFNLRTDPFERADI 205
Cdd:cd16029   364 AAIRVGDWKLIVGKP--------------------LFNIENDPCERNDL 392
SGSH cd16027
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) ...
 5-142 1.97e-25

N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.


Pssm-ID: 293751 [Multi-domain]  Cd Length: 373  Bit Score: 102.97  E-value: 1.97e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   5 YHDvMVEH-DKHVGQLLDLLDELGIAEDTIVMYSTDNGPhmntwpdgamtPFRNEKNSNWEGAFRVPEMVRWPGKIPAGV 83
Cdd:cd16027   191 YYD-EIERlDQQVGEILDELEEDGLLDNTIVIFTSDHGM-----------PFPRAKGTLYDSGLRVPLIVRWPGKIKPGS 258

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1176777471  84 VSNEIISHTDWLPTLLAAAGdAEISEklkkgykagdktfkvHIDGYNFLPYLTGQVEKG 142
Cdd:cd16027   259 VSDALVSFIDLAPTLLDLAG-IEPPE---------------YLQGRSFLPLLKGEKDPG 301
sulfatase_like cd16151
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
 5-205 2.13e-25

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293770 [Multi-domain]  Cd Length: 377  Bit Score: 103.06  E-value: 2.13e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   5 YHDVMVEH-DKHVGQLLDLLDELGIAEDTIVMYSTDNGPH--MNTWPDGAMTpfRNEKNSNWEGAFRVPEMVRWPGKIPA 81
Cdd:cd16151   206 YFPDMVAYmDKLVGKLVDKLEELGLRENTIIIFTGDNGTHrpITSRTNGREV--RGGKGKTTDAGTHVPLIVNWPGLIPA 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  82 GVVSNEIISHTDWLPTLLAAAGdAEISEklkkgykagdktfKVHIDGYNFLPYLTGQVEKGPRQGIIY----FSDDGDLV 157
Cdd:cd16151   284 GGVSDDLVDFSDFLPTLAELAG-APLPE-------------DYPLDGRSFAPQLLGKTGSPRREWIYWyyrnPHKKFGSR 349

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1176777471 158 GLRYDNWKfVFAEQRVpgtvmiwaepfvflrvpkiFNLRTDPFERADI 205
Cdd:cd16151   350 FVRTKRYK-LYADGRF-------------------FDLREDPLEKNPL 377
spARS_like cd16160
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its ...
 5-201 1.02e-24

sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its homologous proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293779 [Multi-domain]  Cd Length: 445  Bit Score: 101.74  E-value: 1.02e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   5 YHDVMVEHDKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMNTWPDGAMT-PFRNEKNSNWEGAFRVPEMVRWPGKIPAGv 83
Cdd:cd16160   224 YGDNINEMSWAVGEVLDTLVDTGLDQNTLVFFLSDHGPHVEYCLEGGSTgGLKGGKGNSWEGGIRVPFIAYWPGTIKPR- 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  84 VSNEIISHTDWLPTLLAAAGdAEISEKLkkgykagdktfkvHIDGYNFLPYLTGQVEKgPRQGIIYFSDDgDLVGLRYDN 163
Cdd:cd16160   303 VSHEVVSTMDIFPTFVDLAG-GTLPTDR-------------IYDGLSITDLLLGEADS-PHDDILYYCCS-RLMAVRYGS 366

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1176777471 164 WKFVFAEQRVPG--TVMIWAEPFVFLR-----------------VPKIFNLRTDPFE 201
Cdd:cd16160   367 YKIHFKTQPLPSqeSLDPNCDGGGPLSdyivcydcedecvtkhnPPLIFDVEKDPGE 423
ARSA cd16158
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely ...
 7-240 5.84e-24

Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. It is a member of the sulfatase family. The arylsulfatase A was located in lysosome-like structures and transported to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. Deficiency of arylsulfatase A leads to the accumulation of cerebroside sulfate, which causes a lethal progressive demyelination. Arylsulfatase A requires the posttranslational oxidation of the -CH2SH group of a conserved cysteine to an aldehyde, yielding a formylglycine to be in an active form.


Pssm-ID: 293777 [Multi-domain]  Cd Length: 479  Bit Score: 99.83  E-value: 5.84e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   7 DVMVEHDKHVGQLLDLLDELGIAEDTIVMYSTDNGPH-MNTWPDGAMTPFRNEKNSNWEGAFRVPEMVRWPGKIPAGvVS 85
Cdd:cd16158   230 DALAELDGSVGELLQTLKENGIDNNTLVFFTSDNGPStMRKSRGGNAGLLKCGKGTTYEGGVREPAIAYWPGRIKPG-VT 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  86 NEIISHTDWLPTLLAAAGdAEISEklkkgykagdktfkVHIDGYNFLPYLTGQvEKGPRQGIIYFSDDGDLV----GLRY 161
Cdd:cd16158   309 HELASTLDILPTIAKLAG-APLPN--------------VTLDGVDMSPILFEQ-GKSPRQTFFYYPTSPDPDkgvfAVRW 372

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471 162 DNWKFVFAEQRV------------PGTVMIWAEPfvflrvPKIFNLRTDPFERADITSNTYWDWMIDRVYltyaaqfLVR 229
Cdd:cd16158   373 GKYKAHFYTQGAahsgttpdkdchPSAELTSHDP------PLLFDLSQDPSENYNLLGLPEYNQVLKQIQ-------QVK 439

                         250
                  ....*....|.
gi 1176777471 230 QFLETFQEFPP 240
Cdd:cd16158   440 ERFEASMKFGE 450
ARSG cd16161
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ...
 5-206 8.34e-24

arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder.


Pssm-ID: 293780 [Multi-domain]  Cd Length: 383  Bit Score: 98.70  E-value: 8.34e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   5 YHDVMVEHDKHVGQLLDLLDELGIAEDTIVMYSTDNGPHM---------NTWPDGAMTPFRNEKNSNWEGAFRVPEMVRW 75
Cdd:cd16161   185 YGDALQEMDDLVGQIMDAVKHAGLKDNTLTWFTSDNGPWEvkcelavgpGTGDWQGNLGGSVAKASTWEGGHREPAIVYW 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  76 PGKIPAGVVSNEIISHTDWLPTLLAAAGdaeiseklkkgykAGDKTFKVhIDGYNFLPYLTGQVEKGPRqgIIYFSDD-- 153
Cdd:cd16161   265 PGRIPANSTSAALVSTLDIFPTVVALAG-------------ASLPPGRI-YDGKDLSPVLFGGSKTGHR--CLFHPNSga 328

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1176777471 154 ---GDLVGLRYDNWKFVFAEQRVPGTVMIWAEPfVFLRVPKIFNLRTDPFERADIT 206
Cdd:cd16161   329 agaGALSAVRCGDYKAHYATGGALACCGSTGPK-LYHDPPLLFDLEVDPAESFPLT 383
sulfatase_like cd16034
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
 9-201 1.68e-23

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293758 [Multi-domain]  Cd Length: 399  Bit Score: 98.02  E-value: 1.68e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   9 MVEH-DKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMntwpdGAMTpfRNEKNSNWEGAFRVPEMVRWPGKIPAGVVSNE 87
Cdd:cd16034   232 MITAlDDNIGRLLDALKELGLLENTIVVFTSDHGDML-----GSHG--LMNKQVPYEESIRVPFIIRYPGKIKAGRVVDL 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  88 IISHTDWLPTLLAAAGdAEISEklkkgykagdktfkvHIDGYNFLPYLTGQVEKGPRQGIIYFS---------DDGDLVG 158
Cdd:cd16034   305 LINTVDIMPTLLGLCG-LPIPD---------------TVEGRDLSPLLLGGKDDEPDSVLLQCFvpfgggsarDGGEWRG 368

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1176777471 159 LRYDNWKFVfaeqrvpgtVMIWAEPFVflrvpkiFNLRTDPFE 201
Cdd:cd16034   369 VRTDRYTYV---------RDKNGPWLL-------FDNEKDPYQ 395
G6S_like cd16031
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); ...
 13-168 2.73e-23

unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.


Pssm-ID: 293755 [Multi-domain]  Cd Length: 429  Bit Score: 97.60  E-value: 2.73e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  13 DKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMN--TWPDgamtpfrneKNSNWEGAFRVPEMVRWPGKIPAGVVSNEIIS 90
Cdd:cd16031   247 DDNVGRILDYLEEQGLADNTIIIYTSDNGFFLGehGLFD---------KRLMYEESIRVPLIIRDPRLIKAGTVVDALVL 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  91 HTDWLPTLLAAAGdAEISEklkkgykagdktfkvHIDGYNFLPYLTGQVEKGPRQGIIY---FSDDGDLV----GLRYDN 163
Cdd:cd16031   318 NIDFAPTILDLAG-VPIPE---------------DMQGRSLLPLLEGEKPVDWRKEFYYeyyEEPNFHNVptheGVRTER 381


                  ....*
gi 1176777471 164 WKFVF 168
Cdd:cd16031   382 YKYIY 386
Sulfatase pfam00884
Sulfatase;
13-103 2.37e-20

Sulfatase;


Pssm-ID: 459979 [Multi-domain]  Cd Length: 298  Bit Score: 87.86  E-value: 2.37e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  13 DKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMntwpDGAMTPFRNEK-NSNWEGAFRVPEMVRWPGKIPAGVVSNEIISH 91
Cdd:pfam00884 210 DDAIGRVLDKLEENGLLDNTLVVYTSDHGESL----GEGGGYLHGGKyDNAPEGGYRVPLLIWSPGGKAKGQKSEALVSH 285

                          90
                  ....*....|..
gi 1176777471  92 TDWLPTLLAAAG 103
Cdd:pfam00884 286 VDLFPTILDLAG 297
sulfatase_like cd16149
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
 13-105 2.62e-20

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293768 [Multi-domain]  Cd Length: 257  Bit Score: 86.91  E-value: 2.62e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  13 DKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMN----------TWPdgamtpfrneknSN-WEGAFRVPEMVRWPGKIPA 81
Cdd:cd16149   152 DRNVGRLLDELEELGLTENTLVIFTSDNGFNMGhhgiwgkgngTFP------------LNmYDNSVKVPFIIRWPGVVPA 219

                          90       100
                  ....*....|....*....|....
gi 1176777471  82 GVVSNEIISHTDWLPTLLAAAGDA 105
Cdd:cd16149   220 GRVVDSLVSAYDFFPTLLELAGVD 243
choline-sulfatase cd16032
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from ...
 13-199 1.27e-19

choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from choline. The symbiotic soil bacterium Rhizobium meliloti can synthesize glycine betaine from choline-O-sulphate and choline to protect itself from osmotic stress. This biosynthetic pathway is encoded by the betICBA locus, which comprises a regulatory gene, betI, and three structural genes, betC (choline sulfatase), betB (betaine aldehyde dehydrogenase), and betA (choline dehydrogenase). betICBA genes constitute a single operon.


Pssm-ID: 293756 [Multi-domain]  Cd Length: 327  Bit Score: 86.48  E-value: 1.27e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  13 DKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMntwpdG------AMTPFrneknsnwEGAFRVPEMVRWPGKIPAGVVSn 86
Cdd:cd16032   174 DDKVGQLLDTLERTGLADDTIVIFTSDHGDML-----GerglwyKMSFF--------EGSARVPLIISAPGRFAPRRVA- 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  87 EIISHTDWLPTLLAAAGDaeiseklkkgykaGDKTFKVHIDGYNFLPYLTGQVEKGPRQGIIYFSDDG---DLVGLRYDN 163
Cdd:cd16032   240 EPVSLVDLLPTLVDLAGG-------------GTAPHVPPLDGRSLLPLLEGGDSGGEDEVISEYLAEGavaPCVMIRRGR 306

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1176777471 164 WKFVFAEqrvpgtvmiwAEPfvflrvPKIFNLRTDP 199
Cdd:cd16032   307 WKFIYCP----------GDP------DQLFDLEADP 326
sulfatase_like cd16152
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
 1-202 2.15e-19

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293771 [Multi-domain]  Cd Length: 373  Bit Score: 86.13  E-value: 2.15e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   1 WQSFYHDV--MVEH-DKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMNTwpdgamtpfRNE--KNSNWEGAFRVPEMVRW 75
Cdd:cd16152   170 WAEELPDYlgCCERlDENVGRIRDALKELGLYDNTIIVFTSDHGCHFRT---------RNAeyKRSCHESSIRVPLVIYG 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  76 PGkIPAGVVSNEIISHTDWLPTLLAAAGdAEISEKLkkgykagdktfkvhiDGYNFLPYLTGQVEkgPRQGIIYFSDDGD 155
Cdd:cd16152   241 PG-FNGGGRVEELVSLIDLPPTLLDAAG-IDVPEEM---------------QGRSLLPLVDGKVE--DWRNEVFIQISES 301

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1176777471 156 LVG--LRYDNWKFVFAEQRVPGtvmiWAEPFVFLRVPK-IFNLRTDPFER 202
Cdd:cd16152   302 QVGraIRTDRWKYSVAAPDKDG----WKDSGSDVYVEDyLYDLEADPYEL 347
GALNS cd16157
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ...
 5-209 1.00e-18

galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.


Pssm-ID: 293776 [Multi-domain]  Cd Length: 466  Bit Score: 84.83  E-value: 1.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   5 YHDVMVEHDKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMNTWPD--GAMTPFRNEKNSNWEGAFRVPEMVRWPGKIPAG 82
Cdd:cd16157   226 YGDAVMELDSSVGKILESLKSLGIENNTFVFFSSDNGAALISAPEqgGSNGPFLCGKQTTFEGGMREPAIAWWPGHIKPG 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  83 VVSNEIISHTDWLPTLLAAAGDAEISEKLkkgykagdktfkvhIDGYNFLPYL-TGQVEKGPrqgIIYFSDDgDLVGLRY 161
Cdd:cd16157   306 QVSHQLGSLMDLFTTSLALAGLPIPSDRA--------------IDGIDLLPVLlNGKEKDRP---IFYYRGD-ELMAVRL 367

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1176777471 162 DNWKFVF-------AEQR----------VPGTVMIWAEPFVFLrvPKIFNLRTDPFERADITSNT 209
Cdd:cd16157   368 GQYKAHFwtwsnswEEFRkginfcpgqnVPGVTTHNQTDHTKL--PLLFHLGRDPGEKYPISFKS 430
sulfatase_like cd16033
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
 13-168 2.14e-18

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293757 [Multi-domain]  Cd Length: 411  Bit Score: 83.81  E-value: 2.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  13 DKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMntwpdGAMTPFrNEKNSNWEGAFRVPEMVRWPGKIPAGVVSNEIISHT 92
Cdd:cd16033   227 DDAIGRILDALEELGLADDTLVIFTSDHGDAL-----GAHRLW-DKGPFMYEETYRIPLIIKWPGVIAAGQVVDEFVSLL 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  93 DWLPTLLAAAGdAEISEKlkkgykagdktfkvhIDGYNFLPYLTGQVEKGPRQGiIYFSDDGDLVGL-----RYDNWKFV 167
Cdd:cd16033   301 DLAPTILDLAG-VDVPPK---------------VDGRSLLPLLRGEQPEDWRDE-VVTEYNGHEFYLpqrmvRTDRYKYV 363


                  .
gi 1176777471 168 F 168
Cdd:cd16033   364 F 364
G6S cd16147
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); ...
 13-103 4.77e-18

glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficient of N-acetylglucosamine-6-sulfatase results in disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease. SULF1 encodes an extracellular heparan sulfate endosulfatase, that removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs).


Pssm-ID: 293766 [Multi-domain]  Cd Length: 396  Bit Score: 82.60  E-value: 4.77e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  13 DKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMNT--WPDGAMTPFrneknsnwEGAFRVPEMVRWPGkIPAGVVSNEIIS 90
Cdd:cd16147   252 DDLVERLVNTLEATGQLDNTYIIYTSDNGYHLGQhrLPPGKRTPY--------EEDIRVPLLVRGPG-IPAGVTVDQLVS 322

                          90
                  ....*....|...
gi 1176777471  91 HTDWLPTLLAAAG 103
Cdd:cd16147   323 NIDLAPTILDLAG 335
sulfatase_like cd16037
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
 9-168 2.77e-17

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293760 [Multi-domain]  Cd Length: 321  Bit Score: 79.89  E-value: 2.77e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   9 MVE-HDKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMNT---WpdgamtpfrnEKNSNWEGAFRVPEMVRWPGkIPAGVV 84
Cdd:cd16037   167 LVEfLDENIGRVLDALEELGLLDNTLIIYTSDHGDMLGErglW----------GKSTMYEESVRVPMIISGPG-IPAGKR 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  85 SNEIISHTDWLPTLLAAAGdAEISEklkkgykagdktfkvHIDGYNFLPYLTGQVEKgPRQGIIYFSDDGDLVG---LRY 161
Cdd:cd16037   236 VKTPVSLVDLAPTILEAAG-APPPP---------------DLDGRSLLPLAEGPDDP-DRVVFSEYHAHGSPSGafmLRK 298


                  ....*..
gi 1176777471 162 DNWKFVF 168
Cdd:cd16037   299 GRWKYIY 305
PMH cd16028
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase ...
 1-201 4.75e-16

Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase/phosphodiesterase hydrolyses phosphonate monoesters or phosphate diesters using a posttranslationally formed formylglycine as the catalytic nucleophile. PMH is the member of the alkaline phosphatase superfamily. The structure of PMH is more homologous to arylsulfatase than alkaline phosphatase. Sulfatases also use formylglycine as catalytic nucleophile.


Pssm-ID: 293752 [Multi-domain]  Cd Length: 449  Bit Score: 76.91  E-value: 4.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   1 WQSFYHDVMVEHDKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMNtwpDGAMTpfrnEKNSNWEGAFRVPEMVRWPG--- 77
Cdd:cd16028   236 MRATYLGLIAEVDDHLGRLFDYLKETGQWDDTLIVFTSDHGEQLG---DHWLW----GKDGFFDQAYRVPLIVRDPRrea 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  78 KIPAGVVSNEIISHTDWLPTLLAAAGdAEISEklkkgykagdktfkvHIDGYNFLPYLTGQVEKGPRQGIIYFSDDGDLV 157
Cdd:cd16028   309 DATRGQVVDAFTESVDVMPTILDWLG-GEIPH---------------QCDGRSLLPLLAGAQPSDWRDAVHYEYDFRDVS 372

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1176777471 158 G------------------LRYDNWKFVFaeqrvpgtvmiwaepFVFLRvPKIFNLRTDPFE 201
Cdd:cd16028   373 TrrpqealglspdecslavIRDERWKYVH---------------FAALP-PLLFDLKNDPGE 418
sulfatase_like cd16148
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
 13-103 7.67e-15

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293767 [Multi-domain]  Cd Length: 271  Bit Score: 72.20  E-value: 7.67e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  13 DKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMN---TWPDGAMTPfrneknsnWEGAFRVPEMVRWPGKIPAGVVSnEII 89
Cdd:cd16148   173 DEQIGRLLDKLKELGLLEDTLVIVTSDHGEEFGehgLYWGHGSNL--------YDEQLHVPLIIRWPGKEPGKRVD-ALV 243

                          90
                  ....*....|....
gi 1176777471  90 SHTDWLPTLLAAAG 103
Cdd:cd16148   244 SHIDIAPTLLDLLG 257
iduronate-2-sulfatase cd16030
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the ...
 16-103 2.88e-14

iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates, including steroids, carbohydrates and proteins. Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in the iduronate 2-sulfatase gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome.


Pssm-ID: 293754 [Multi-domain]  Cd Length: 435  Bit Score: 71.84  E-value: 2.88e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  16 VGQLLDLLDELGIAEDTIVMYSTDNGPHM---NTWpdgamtpfrnEKNSNWEGAFRVPEMVRWPGKIPAGVVSNEIISHT 92
Cdd:cd16030   274 VGRVLDALEELGLADNTIVVLWSDHGWHLgehGHW----------GKHTLFEEATRVPLIIRAPGVTKPGKVTDALVELV 343

                          90
                  ....*....|.
gi 1176777471  93 DWLPTLLAAAG 103
Cdd:cd16030   344 DIYPTLAELAG 354
sulfatase_like cd16035
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
 1-167 4.76e-14

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293759 [Multi-domain]  Cd Length: 311  Bit Score: 70.31  E-value: 4.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   1 WQSFYHDVMVEHDKHVGQLLDLLDELGIAEDTIVMYSTDNGpHMntwpdgAMTPFRNEKNSN-WEGAFRVPEMVRWPGKI 79
Cdd:cd16035   165 FRNFYYNLIRDVDRQIGRVLDALDASGLADNTIVVFTSDHG-EM------GGAHGLRGKGFNaYEEALHVPLIISHPDLF 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  80 PAGVVSNEIISHTDWLPTLLAAAGDAEisEKLKKGYKAgdktFKvhidGYNFLPYLTGQVEKGPRQGIIYFsddgdlvgl 159
Cdd:cd16035   238 GTGQTTDALTSHIDLLPTLLGLAGVDA--EARATEAPP----LP----GRDLSPLLTDADADAVRDGILFT--------- 298


                  ....*...
gi 1176777471 160 rYDNWKFV 167
Cdd:cd16035   299 -YDRYKFA 305
sulfatase_like cd16155
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
 9-201 2.05e-13

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293774 [Multi-domain]  Cd Length: 372  Bit Score: 69.13  E-value: 2.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   9 MVEH-DKHVGQLLDLLDELGIAEDTIVMYSTDN----GPHmntwpdGAMTpfrneKNSNWEGAFRVPEMVRWPGkIPAGV 83
Cdd:cd16155   197 MITHlDAQIGRILDALEASGELDNTIIVFTSDHglavGSH------GLMG-----KQNLYEHSMRVPLIISGPG-IPKGK 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  84 VSNEIISHTDWLPTLLAAAGdAEISEklkkgykagdktfkvHIDGYNFLPYLTGQVEKgPRQgIIYFSDDGDLVGLRYDN 163
Cdd:cd16155   265 RRDALVYLQDVFPTLCELAG-IEIPE---------------SVEGKSLLPVIRGEKKA-VRD-TLYGAYRDGQRAIRDDR 326

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1176777471 164 WKfvfaeqrvpgtvMIWAEPFVflRVPKIFNLRTDPFE 201
Cdd:cd16155   327 WK------------LIIYVPGV--KRTQLFDLKKDPDE 350
ALP_like cd00016
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ...
 5-102 2.35e-11

alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.


Pssm-ID: 293732 [Multi-domain]  Cd Length: 237  Bit Score: 62.05  E-value: 2.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   5 YHDVMVEHDKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMntWPDGaMTPFRNEKNSNWEGAFRVPEMVRWPGkIPAGVV 84
Cdd:cd00016   144 YYDAVEEIDERIGKVLDALKKAGDADDTVIIVTADHGGID--KGHG-GDPKADGKADKSHTGMRVPFIAYGPG-VKKGGV 219

                          90
                  ....*....|....*...
gi 1176777471  85 SNEIISHTDWLPTLLAAA 102
Cdd:cd00016   220 KHELISQYDIAPTLADLL 237
sulfatase_like cd16153
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
 13-103 2.46e-10

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293772 [Multi-domain]  Cd Length: 282  Bit Score: 59.31  E-value: 2.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  13 DKHVGQLLDLLDELGIA---EDTIVMYSTDNGPHMNTwpDGAMTpfrneKNSNWEGAFRVPEMVRWPGKI--PAGVVSNE 87
Cdd:cd16153   178 DAQVGRAVEAFKAYSLKqdrDYTIVYVTGDHGWHLGE--QGILA-----KFTFWPQSHRVPLIVVSSDKLkaPAGKVRHD 250

                          90
                  ....*....|....*.
gi 1176777471  88 IISHTDWLPTLLAAAG 103
Cdd:cd16153   251 FVEFVDLAPTLLAAAG 266
PRK13759 PRK13759
arylsulfatase; Provisional
 5-154 3.45e-09

arylsulfatase; Provisional


Pssm-ID: 237491 [Multi-domain]  Cd Length: 485  Bit Score: 56.60  E-value: 3.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   5 YHDVMVEHDKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMntwpdGAMTPFRneKNSNWEGAFRVPEMVRWPG---KIPA 81
Cdd:PRK13759  270 YYGLITHIDHQIGRFLQALKEFGLLDNTIILFVSDHGDML-----GDHYLFR--KGYPYEGSAHIPFIIYDPGgllAGNR 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  82 GVVSNEIISHTDWLPTLLAAAG-------DAEISEKLKKGYKAGDKTF--KVHIDGYNFLPYLTGQVEKgprqgIIYFSD 152
Cdd:PRK13759  343 GTVIDQVVELRDIMPTLLDLAGgtipddvDGRSLKNLIFGQYEGWRPYlhGEHALGYSSDNYLTDGKWK-----YIWFSQ 417


                  ..
gi 1176777471 153 DG 154
Cdd:PRK13759  418 TG 419
sulfatase_like cd16150
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
 9-202 2.06e-08

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293769 [Multi-domain]  Cd Length: 423  Bit Score: 54.16  E-value: 2.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   9 MVEH-DKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMNtwpDGAMTpfrnEKnsnWEGAF-----RVPEMVRwPGKIPAG 82
Cdd:cd16150   205 MVSRlDHQFGRLLEALKETGLYDDTAVFFFSDHGDYTG---DYGLV----EK---WPNTFedcltRVPLIIK-PPGGPAG 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  83 VVSNEIISHTDWLPTLLAAAGdaeISEK-------LKKGYKAGDKTFK--VHIDGyNFLPYLTGQVEKGPRQGIIYFSD- 152
Cdd:cd16150   274 GVSDALVELVDIPPTLLDLAG---IPLShthfgrsLLPVLAGETEEHRdaVFSEG-GRLHGEEQAMEGGHGPYDLKWPRl 349

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1176777471 153 ----DGDLVG----LRYDNWKFVFAEQrvpgtvmiwaEPfvflrvPKIFNLRTDPFER 202
Cdd:cd16150   350 lqqeEPPEHTkavmIRTRRYKYVYRLY----------EP------DELYDLEADPLEL 391
ARSK cd16171
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a ...
 2-199 2.29e-08

arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a lysosomal sulfatase which exhibits an acidic pH optimum for catalytic activity against arylsulfate substrates. Other names for ARSK include arylsulfatase K and TSULF. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293781 [Multi-domain]  Cd Length: 366  Bit Score: 54.08  E-value: 2.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   2 QSFYHDVMVEHDKHVGQLLDLLDELGIAEDTIVMYSTDNGphmntwpDGAMTPFRNEKNSNWEGAFRVPEMVRWPGkIPA 81
Cdd:cd16171   195 RAFYYAMCAETDAMLGEIISALKDTGLLDKTYVFFTSDHG-------ELAMEHRQFYKMSMYEGSSHVPLLIMGPG-IKA 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  82 GVVSNEIISHTDWLPTLLAAAGdAEISEKLkkgykagdktfkvhiDGYNFLPYLTGQVE-----KGPRQGIIYFSDDGDL 156
Cdd:cd16171   267 GQQVSDVVSLVDIYPTMLDIAG-VPQPQNL---------------SGYSLLPLLSESSIkespsRVPHPDWVLSEFHGCN 330

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1176777471 157 VG-----LRYDNWKFV-FAE-QRVPgtvmiwaepfvflrvPKIFNLRTDP 199
Cdd:cd16171   331 VNastymLRTNSWKYIaYADgNSVP---------------PQLFDLSKDP 365
sulfatase_like cd16156
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the ...
 13-103 2.73e-08

uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293775 [Multi-domain]  Cd Length: 468  Bit Score: 53.93  E-value: 2.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  13 DKHVGQLLDLLDElgIAEDTIVMYSTDNGPHMNT---WPDGAmtpfrneknSNWEGAFRVPEMVRWPGKIPAGVVSNEII 89
Cdd:cd16156   251 DYEIGRVLDAADE--IAEDAWVIYTSDHGDMLGAhklWAKGP---------AVYDEITNIPLIIRGKGGEKAGTVTDTPV 319

                          90
                  ....*....|....
gi 1176777471  90 SHTDWLPTLLAAAG 103
Cdd:cd16156   320 SHIDLAPTILDYAG 333
YejM COG3083
Periplasmic protein PbgA/YejM, regulator of the LPS biosynthesis, AlkP superfamily [Cell wall ...
 13-99 5.70e-08

Periplasmic protein PbgA/YejM, regulator of the LPS biosynthesis, AlkP superfamily [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 442317 [Multi-domain]  Cd Length: 603  Bit Score: 52.99  E-value: 5.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  13 DKHVGQLLDLLDELGIAEDTIVMYSTDNGphmntwpdgamTPFRNEKNSNWE--GAF-----RVPEMVRWPGKiPAGVVS 85
Cdd:COG3083   437 DSQIGRVLDTLEQRGLLENTIVIITADHG-----------EEFNENGQNYWGhnSNFsryqlQVPLVIHWPGT-PPQVIS 504

                          90
                  ....*....|....
gi 1176777471  86 NeIISHTDWLPTLL 99
Cdd:COG3083   505 K-LTSHLDIVPTLM 517
LTA_synthase cd16015
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer ...
 5-103 1.47e-06

Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.


Pssm-ID: 293739 [Multi-domain]  Cd Length: 283  Bit Score: 48.45  E-value: 1.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   5 YHDVMVEHDKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMNtwpdgamtPFRNEKNSNWEGAFRVPEMVRWPGKIPAGVV 84
Cdd:cd16015   194 YLNAIHYTDKALGEFIEKLKKSGLYENTIIVIYGDHLPSLG--------SDYDETDEDPLDLYRTPLLIYSPGLKKPKKI 265

                          90
                  ....*....|....*....
gi 1176777471  85 sNEIISHTDWLPTLLAAAG 103
Cdd:cd16015   266 -DRVGSQIDIAPTLLDLLG 283
sulfatase_like cd16154
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
 4-201 2.76e-05

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293773 [Multi-domain]  Cd Length: 372  Bit Score: 44.65  E-value: 2.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471   4 FYHDVMVEH-DKHVGQLLDLLDElGIAEDTIVMYSTDNGphmntwpdgamTP--------FRNE-KNSNWEGAFRVPEMV 73
Cdd:cd16154   207 PYYLAAIEAmDTEIGRLLASIDE-EERENTIIIFIGDNG-----------TPgqvvdlpyTRNHaKGSLYEGGINVPLIV 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  74 RWPGKIPAGVVSNEIISHTDWLPTLLAAAGDAEISeklkkgykagdktfkVHiDGYNFLPYLTGqVEKGPRQGII--YFS 151
Cdd:cd16154   275 SGAGVERANERESALVNATDLYATIAELAGVDAAE---------------IH-DSVSFKPLLSD-VNASTRQYNYteYES 337

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1176777471 152 DDGDLVGLRYDNWKFVFAEQrvpGTVMiwaepfvflrvpkIFNLRTDPFE 201
Cdd:cd16154   338 PTTTGWATRNQYYKLIESEN---GQEE-------------LYDLINDPSE 371
MdoB COG1368
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ...
 13-103 2.30e-03

Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440979 [Multi-domain]  Cd Length: 576  Bit Score: 38.87  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176777471  13 DKHVGQLLDLLDELGIAEDTIVMYSTDNGPHMNTWPDGAMTPFRneknsnwegaFRVPeMVRWPGKIPAGVVSNEIISHT 92
Cdd:COG1368   427 DQALGEFIEKLKKSGWYDNTIFVIYGDHGPRSPGKTDYENPLER----------YRVP-LLIYSPGLKKPKVIDTVGSQI 495

                          90
                  ....*....|.
gi 1176777471  93 DWLPTLLAAAG 103
Cdd:COG1368   496 DIAPTLLDLLG 506
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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