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Conserved domains on  [gi|1200388011|gb|OUV06356|]
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phosphopantothenoylcysteine decarboxylase [bacterium TMED80]

Protein Classification

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase( domain architecture ID 11418829)

bifunctional phosphopantothenoylcysteine decarboxylase (CoaC)/phosphopantothenate synthase (CoaB) catalyzes two steps in the biosynthesis of coenzyme A, the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, followed by its decarboxylation to form 4'-phosphopantotheine

EC:  4.1.1.36|6.3.2.5
Gene Ontology:  GO:0071513|GO:0010181|GO:0046872|GO:0004632|GO:0004633|GO:0015937|GO:0015941

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
 3-400 0e+00

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


:

Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 521.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011   3 SLRGKKIILGISAGIAAYKTPILVRLLKQKGAQVRVVLTPDAHAFVTPLTLSVVSEEEVLSSFVAEDKDNpvWNDHVALG 82
Cdd:COG0452     1 MLAGKRILLGVTGGIAAYKAAELVRLLRKAGAEVRVVMTEAATEFVTPLTFQALSGNPVYTDLFDEEAEA--EMGHIELA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011  83 LWADLLLIAPATANTLSAMAQAKSNNLLIATYLSARCPIMVAPAMDLDMYAHPANQKNLDTLASYGNQILPVGEGALASG 162
Cdd:COG0452    79 RWADLIVIAPATANTIAKLAHGIADDLLTTTLLATTCPVLVAPAMNTNMWEHPATQRNLATLRERGVHIIGPASGELACG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 163 LVGKGRLLEPDQIVERVIVHFNSALPLSRKKVLITAGPTYEKIDPVRYIGNFSSGKMGYALAEEAHALGAEVYLILGPHA 242
Cdd:COG0452   159 DVGKGRMAEPEEIVEAIEALLAPKKDLAGKKVLITAGPTREPIDPVRFISNRSSGKMGYALAEAAAARGAEVTLVSGPVA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 243 LDlsnAPFAVK--EVVSATEMETAVFKKFPTvdfaiaaaavadfKPLAPKPHKIKKEEGIPSIELQPNPDILARMGKEKK 320
Cdd:COG0452   239 LP---TPAGVEriDVESAEEMLEAVLAAFPDadivimaaavadyRPAEVADQKIKKTDDPLTLELVKNPDILAELGARKK 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 321 Q-QFVLGFALETQDNWKEALAKKRRKKADAIVMNSLTDPGAGFASDTNKITYIGENEKPKRFSLKSKNEVAKDIWNEIMD 399
Cdd:COG0452   316 PgQFLVGFAAETENLLENARAKLARKNLDLIVANDVSDAGAGFGSDTNAVTLLDKDGREEELPLMSKLEVARRILDEIAE 395


                  .
gi 1200388011 400 Q 400
Cdd:COG0452   396 L 396
 
Name Accession Description Interval E-value
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
 3-400 0e+00

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 521.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011   3 SLRGKKIILGISAGIAAYKTPILVRLLKQKGAQVRVVLTPDAHAFVTPLTLSVVSEEEVLSSFVAEDKDNpvWNDHVALG 82
Cdd:COG0452     1 MLAGKRILLGVTGGIAAYKAAELVRLLRKAGAEVRVVMTEAATEFVTPLTFQALSGNPVYTDLFDEEAEA--EMGHIELA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011  83 LWADLLLIAPATANTLSAMAQAKSNNLLIATYLSARCPIMVAPAMDLDMYAHPANQKNLDTLASYGNQILPVGEGALASG 162
Cdd:COG0452    79 RWADLIVIAPATANTIAKLAHGIADDLLTTTLLATTCPVLVAPAMNTNMWEHPATQRNLATLRERGVHIIGPASGELACG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 163 LVGKGRLLEPDQIVERVIVHFNSALPLSRKKVLITAGPTYEKIDPVRYIGNFSSGKMGYALAEEAHALGAEVYLILGPHA 242
Cdd:COG0452   159 DVGKGRMAEPEEIVEAIEALLAPKKDLAGKKVLITAGPTREPIDPVRFISNRSSGKMGYALAEAAAARGAEVTLVSGPVA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 243 LDlsnAPFAVK--EVVSATEMETAVFKKFPTvdfaiaaaavadfKPLAPKPHKIKKEEGIPSIELQPNPDILARMGKEKK 320
Cdd:COG0452   239 LP---TPAGVEriDVESAEEMLEAVLAAFPDadivimaaavadyRPAEVADQKIKKTDDPLTLELVKNPDILAELGARKK 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 321 Q-QFVLGFALETQDNWKEALAKKRRKKADAIVMNSLTDPGAGFASDTNKITYIGENEKPKRFSLKSKNEVAKDIWNEIMD 399
Cdd:COG0452   316 PgQFLVGFAAETENLLENARAKLARKNLDLIVANDVSDAGAGFGSDTNAVTLLDKDGREEELPLMSKLEVARRILDEIAE 395


                  .
gi 1200388011 400 Q 400
Cdd:COG0452   396 L 396
PRK05579 PRK05579
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
 1-397 2.32e-154

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated


Pssm-ID: 235513 [Multi-domain]  Cd Length: 399  Bit Score: 441.11  E-value: 2.32e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011   1 MQSLRGKKIILGISAGIAAYKTPILVRLLKQKGAQVRVVLTPDAHAFVTPLTLSVVSEEEVLSSFVAEDKDNPVwnDHVA 80
Cdd:PRK05579    1 MRMLAGKRIVLGVSGGIAAYKALELVRRLRKAGADVRVVMTEAAKKFVTPLTFQALSGNPVSTDLWDPAAEAAM--GHIE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011  81 LGLWADLLLIAPATANTLSAMAQAKSNNLLIATYLSARCPIMVAPAMDLDMYAHPANQKNLDTLASYGNQILPVGEGALA 160
Cdd:PRK05579   79 LAKWADLVLIAPATADLIAKLAHGIADDLLTTTLLATTAPVLVAPAMNTQMWENPATQRNLATLRSRGVEIIGPASGRLA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 161 SGLVGKGRLLEPDQIVERVIVHFNSAlPLSRKKVLITAGPTYEKIDPVRYIGNFSSGKMGYALAEEAHALGAEVYLILGP 240
Cdd:PRK05579  159 CGDVGPGRMAEPEEIVAAAERALSPK-DLAGKRVLITAGPTREPIDPVRYITNRSSGKMGYALARAAARRGADVTLVSGP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 241 HALDLsnaPFAVK--EVVSATEMETAVFKKFPTVDFAIAAAAVADFKPLAPKPHKIKKEEGIPSIELQPNPDILARMGKE 318
Cdd:PRK05579  238 VNLPT---PAGVKriDVESAQEMLDAVLAALPQADIFIMAAAVADYRPATVAEGKIKKGEGELTLELVPNPDILAEVAAL 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 319 KKQQ-FVLGFALETQDNWKEALAKKRRKKADAIVMNSLtDPGAGFASDTNKITYIGENEKPKRFSLKSKNEVAKDIWNEI 397
Cdd:PRK05579  315 KDKRpFVVGFAAETGDVLEYARAKLKRKGLDLIVANDV-SAGGGFGSDDNEVTLIWSDGGEVKLPLMSKLELARRLLDEI 393
coaBC_dfp TIGR00521
phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model ...
 4-397 4.10e-114

phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model represents a bifunctional enzyme that catalyzes the second and third steps (cysteine ligation, EC 6.3.2.5, and decarboxylation, EC 4.1.1.36) in the biosynthesis of coenzyme A (CoA) from pantothenate in bacteria. In early descriptions of this flavoprotein, a ts mutation in one region of the protein appeared to cause a defect in DNA metaobolism rather than an increased need for the pantothenate precursor beta-alanine. This protein was then called dfp, for DNA/pantothenate metabolism flavoprotein. The authors responsible for detecting phosphopantothenate--cysteine ligase activity suggest renaming this bifunctional protein coaBC for its role in CoA biosynthesis. This enzyme contains the FMN cofactor, but no FAD or pyruvoyl group. The amino-terminal region contains the phosphopantothenoylcysteine decarboxylase activity. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273116 [Multi-domain]  Cd Length: 391  Bit Score: 338.58  E-value: 4.10e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011   4 LRGKKIILGISAGIAAYKTPILVRLLKQKGAQVRVVLTPDAHAFVTPLTLSVVSEEEVLSSFVAEDKDNPVwndHVALGL 83
Cdd:TIGR00521   1 LENKKILLGVTGGIAAYKTVELVRELVRQGAEVKVIMTEAAKKFITPLTLEALSGHKVVTELWGPIEHNAL---HIDLAK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011  84 WADLLLIAPATANTLSAMAQAKSNNLLIATYLSARCPIMVAPAMDLDMYAHPANQKNLDTLASYGNQILPVGEGALASGL 163
Cdd:TIGR00521  78 WADLILIAPATANTISKIAHGIADDLVSTTALAASAPIILAPAMNENMYNNPAVQENIKRLKDDGYIFIEPRSGLLACGD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 164 VGKGRLLEPDQIVERVIVHFNSALPLSRKKVLITAGPTYEKIDPVRYIGNFSSGKMGYALAEEAHALGAEVYLILGPHAL 243
Cdd:TIGR00521 158 EGKGRLAEPETIVKAAEREFSPKEDLEGKRVLITAGPTREPIDPVRFISNLSSGKMGLALAEAAYKRGADVTLITGPVSL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 244 DLsnaPFAVKE--VVSATEM-ETAVFKKFPTVDFAIAAAAVADFKPLAPKPHKIKKEEGIPSIELQPNPDILARMGKEKK 320
Cdd:TIGR00521 238 LT---PPGVKSikVSTAEEMlEAALNELAKDFDIFISAAAVADFKPKTVFEGKIKKQGEELSLKLVKNPDIIAEVRKIKK 314

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1200388011 321 QQFVLGFALETQDNWKEALAKKRRKK-ADAIVMNSLTDpGAGFASDTNKItYIGENEKPKRFSLKSKNEVAKDIWNEI 397
Cdd:TIGR00521 315 HQVIVGFKAETNDDLIKYAKEKLKKKnLDMIVANDVSQ-GRGFGSDENEV-YIFSKHGHKELPLMSKLEVAERILDEI 390
DFP pfam04127
DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4. ...
 189-370 3.22e-67

DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4.1.1.36) affects synthesis of DNA, and pantothenate metabolism.


Pssm-ID: 461186 [Multi-domain]  Cd Length: 183  Bit Score: 211.11  E-value: 3.22e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 189 LSRKKVLITAGPTYEKIDPVRYIGNFSSGKMGYALAEEAHALGAEVYLILGPHALDLsnaPFAVK--EVVSATEMETAVF 266
Cdd:pfam04127   1 LAGKRVLVTAGPTREPIDPVRFISNRSSGKMGYALARAAAARGAEVTLVSGPTSLPP---PPGVEvvDVESAEEMLEAVL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 267 KKFPtvdfaiaaaavaDF------------KPLAPKPHKIKKEEG--IPSIELQPNPDILARMGKEKKQQFVLGFALETQ 332
Cdd:pfam04127  78 AAFP------------EAdivimaaavadyRPAEVADGKIKKSSGgeELTLELVKNPDILAELGKRKPGQLLVGFAAETE 145

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1200388011 333 DNWKEALAKKRRKKADAIVMNSLTDPGAGFASDTNKIT 370
Cdd:pfam04127 146 DLLENARAKLERKNLDLIVANDVSRPGAGFGSDTNEVT 183
 
Name Accession Description Interval E-value
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
 3-400 0e+00

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 521.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011   3 SLRGKKIILGISAGIAAYKTPILVRLLKQKGAQVRVVLTPDAHAFVTPLTLSVVSEEEVLSSFVAEDKDNpvWNDHVALG 82
Cdd:COG0452     1 MLAGKRILLGVTGGIAAYKAAELVRLLRKAGAEVRVVMTEAATEFVTPLTFQALSGNPVYTDLFDEEAEA--EMGHIELA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011  83 LWADLLLIAPATANTLSAMAQAKSNNLLIATYLSARCPIMVAPAMDLDMYAHPANQKNLDTLASYGNQILPVGEGALASG 162
Cdd:COG0452    79 RWADLIVIAPATANTIAKLAHGIADDLLTTTLLATTCPVLVAPAMNTNMWEHPATQRNLATLRERGVHIIGPASGELACG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 163 LVGKGRLLEPDQIVERVIVHFNSALPLSRKKVLITAGPTYEKIDPVRYIGNFSSGKMGYALAEEAHALGAEVYLILGPHA 242
Cdd:COG0452   159 DVGKGRMAEPEEIVEAIEALLAPKKDLAGKKVLITAGPTREPIDPVRFISNRSSGKMGYALAEAAAARGAEVTLVSGPVA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 243 LDlsnAPFAVK--EVVSATEMETAVFKKFPTvdfaiaaaavadfKPLAPKPHKIKKEEGIPSIELQPNPDILARMGKEKK 320
Cdd:COG0452   239 LP---TPAGVEriDVESAEEMLEAVLAAFPDadivimaaavadyRPAEVADQKIKKTDDPLTLELVKNPDILAELGARKK 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 321 Q-QFVLGFALETQDNWKEALAKKRRKKADAIVMNSLTDPGAGFASDTNKITYIGENEKPKRFSLKSKNEVAKDIWNEIMD 399
Cdd:COG0452   316 PgQFLVGFAAETENLLENARAKLARKNLDLIVANDVSDAGAGFGSDTNAVTLLDKDGREEELPLMSKLEVARRILDEIAE 395


                  .
gi 1200388011 400 Q 400
Cdd:COG0452   396 L 396
PRK05579 PRK05579
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
 1-397 2.32e-154

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated


Pssm-ID: 235513 [Multi-domain]  Cd Length: 399  Bit Score: 441.11  E-value: 2.32e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011   1 MQSLRGKKIILGISAGIAAYKTPILVRLLKQKGAQVRVVLTPDAHAFVTPLTLSVVSEEEVLSSFVAEDKDNPVwnDHVA 80
Cdd:PRK05579    1 MRMLAGKRIVLGVSGGIAAYKALELVRRLRKAGADVRVVMTEAAKKFVTPLTFQALSGNPVSTDLWDPAAEAAM--GHIE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011  81 LGLWADLLLIAPATANTLSAMAQAKSNNLLIATYLSARCPIMVAPAMDLDMYAHPANQKNLDTLASYGNQILPVGEGALA 160
Cdd:PRK05579   79 LAKWADLVLIAPATADLIAKLAHGIADDLLTTTLLATTAPVLVAPAMNTQMWENPATQRNLATLRSRGVEIIGPASGRLA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 161 SGLVGKGRLLEPDQIVERVIVHFNSAlPLSRKKVLITAGPTYEKIDPVRYIGNFSSGKMGYALAEEAHALGAEVYLILGP 240
Cdd:PRK05579  159 CGDVGPGRMAEPEEIVAAAERALSPK-DLAGKRVLITAGPTREPIDPVRYITNRSSGKMGYALARAAARRGADVTLVSGP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 241 HALDLsnaPFAVK--EVVSATEMETAVFKKFPTVDFAIAAAAVADFKPLAPKPHKIKKEEGIPSIELQPNPDILARMGKE 318
Cdd:PRK05579  238 VNLPT---PAGVKriDVESAQEMLDAVLAALPQADIFIMAAAVADYRPATVAEGKIKKGEGELTLELVPNPDILAEVAAL 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 319 KKQQ-FVLGFALETQDNWKEALAKKRRKKADAIVMNSLtDPGAGFASDTNKITYIGENEKPKRFSLKSKNEVAKDIWNEI 397
Cdd:PRK05579  315 KDKRpFVVGFAAETGDVLEYARAKLKRKGLDLIVANDV-SAGGGFGSDDNEVTLIWSDGGEVKLPLMSKLELARRLLDEI 393
coaBC_dfp TIGR00521
phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model ...
 4-397 4.10e-114

phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model represents a bifunctional enzyme that catalyzes the second and third steps (cysteine ligation, EC 6.3.2.5, and decarboxylation, EC 4.1.1.36) in the biosynthesis of coenzyme A (CoA) from pantothenate in bacteria. In early descriptions of this flavoprotein, a ts mutation in one region of the protein appeared to cause a defect in DNA metaobolism rather than an increased need for the pantothenate precursor beta-alanine. This protein was then called dfp, for DNA/pantothenate metabolism flavoprotein. The authors responsible for detecting phosphopantothenate--cysteine ligase activity suggest renaming this bifunctional protein coaBC for its role in CoA biosynthesis. This enzyme contains the FMN cofactor, but no FAD or pyruvoyl group. The amino-terminal region contains the phosphopantothenoylcysteine decarboxylase activity. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273116 [Multi-domain]  Cd Length: 391  Bit Score: 338.58  E-value: 4.10e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011   4 LRGKKIILGISAGIAAYKTPILVRLLKQKGAQVRVVLTPDAHAFVTPLTLSVVSEEEVLSSFVAEDKDNPVwndHVALGL 83
Cdd:TIGR00521   1 LENKKILLGVTGGIAAYKTVELVRELVRQGAEVKVIMTEAAKKFITPLTLEALSGHKVVTELWGPIEHNAL---HIDLAK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011  84 WADLLLIAPATANTLSAMAQAKSNNLLIATYLSARCPIMVAPAMDLDMYAHPANQKNLDTLASYGNQILPVGEGALASGL 163
Cdd:TIGR00521  78 WADLILIAPATANTISKIAHGIADDLVSTTALAASAPIILAPAMNENMYNNPAVQENIKRLKDDGYIFIEPRSGLLACGD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 164 VGKGRLLEPDQIVERVIVHFNSALPLSRKKVLITAGPTYEKIDPVRYIGNFSSGKMGYALAEEAHALGAEVYLILGPHAL 243
Cdd:TIGR00521 158 EGKGRLAEPETIVKAAEREFSPKEDLEGKRVLITAGPTREPIDPVRFISNLSSGKMGLALAEAAYKRGADVTLITGPVSL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 244 DLsnaPFAVKE--VVSATEM-ETAVFKKFPTVDFAIAAAAVADFKPLAPKPHKIKKEEGIPSIELQPNPDILARMGKEKK 320
Cdd:TIGR00521 238 LT---PPGVKSikVSTAEEMlEAALNELAKDFDIFISAAAVADFKPKTVFEGKIKKQGEELSLKLVKNPDIIAEVRKIKK 314

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1200388011 321 QQFVLGFALETQDNWKEALAKKRRKK-ADAIVMNSLTDpGAGFASDTNKItYIGENEKPKRFSLKSKNEVAKDIWNEI 397
Cdd:TIGR00521 315 HQVIVGFKAETNDDLIKYAKEKLKKKnLDMIVANDVSQ-GRGFGSDENEV-YIFSKHGHKELPLMSKLEVAERILDEI 390
PRK13982 PRK13982
bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; ...
 3-397 2.49e-88

bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional


Pssm-ID: 172484 [Multi-domain]  Cd Length: 475  Bit Score: 275.48  E-value: 2.49e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011   3 SLRGKKIILGISAGIAAYKTPILVRLLKQKGAQVRVVLTPDAHAFVTPLTLSVVSEEEVLSS-FVAEDKDNPvwnDHVAL 81
Cdd:PRK13982   67 SLASKRVTLIIGGGIAAYKALDLIRRLKERGAHVRCVLTKAAQQFVTPLTASALSGQRVYTDlFDPESEFDA---GHIRL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011  82 GLWADLLLIAPATANTLSAMAQAKSNNLLIATYLSARCPIMVAPAMDLDMYAHPANQKNLDTLASYGNQILPVGEGALA- 160
Cdd:PRK13982  144 ARDCDLIVVAPATADLMAKMANGLADDLASAILLAANRPILLAPAMNPLMWNNPATRRNVAQLKRDGVHMIGPNAGEMAe 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 161 SGLVGKGRLLEPDQIVERV--IVHFNSALPLSRKKVLITAGPTYEKIDPVRYIGNFSSGKMGYALAEEAHALGAEVYLIL 238
Cdd:PRK13982  224 RGEAGVGRMAEPLEIAAAAeaLLRPPQPKPLAGRRVLITAGPTHEPIDPVRYIANRSSGKQGFAIAAAAAAAGAEVTLIS 303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 239 GPHALDlsnAPFAVK--EVVSATEMETAVFKKFPTvDFAIAAAAVADFKPLAPKPHKIKK-EEGIPSIELQPNPDILARM 315
Cdd:PRK13982  304 GPVDLA---DPQGVKviHVESARQMLAAVEAALPA-DIAIFAAAVADWRVATEGGQKLKKgAAGPPPLQLVENPDILATI 379

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 316 GK--EKKQQFVLGFALETQDNWKEALAKKRRKKADAIVMNSLTDPGAGFASDTNKI---TYIGENEKPKRFSLKSKNEVA 390
Cdd:PRK13982  380 SKlaENRPPLVIGFAAETEHLIDNARAKLARKGCDWIVANDVSPATGVMGGDRNTVhllSRDGDAEKVESWPVMTKDEVA 459


                  ....*..
gi 1200388011 391 KDIWNEI 397
Cdd:PRK13982  460 TALVARI 466
DFP pfam04127
DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4. ...
 189-370 3.22e-67

DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4.1.1.36) affects synthesis of DNA, and pantothenate metabolism.


Pssm-ID: 461186 [Multi-domain]  Cd Length: 183  Bit Score: 211.11  E-value: 3.22e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 189 LSRKKVLITAGPTYEKIDPVRYIGNFSSGKMGYALAEEAHALGAEVYLILGPHALDLsnaPFAVK--EVVSATEMETAVF 266
Cdd:pfam04127   1 LAGKRVLVTAGPTREPIDPVRFISNRSSGKMGYALARAAAARGAEVTLVSGPTSLPP---PPGVEvvDVESAEEMLEAVL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 267 KKFPtvdfaiaaaavaDF------------KPLAPKPHKIKKEEG--IPSIELQPNPDILARMGKEKKQQFVLGFALETQ 332
Cdd:pfam04127  78 AAFP------------EAdivimaaavadyRPAEVADGKIKKSSGgeELTLELVKNPDILAELGKRKPGQLLVGFAAETE 145

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1200388011 333 DNWKEALAKKRRKKADAIVMNSLTDPGAGFASDTNKIT 370
Cdd:pfam04127 146 DLLENARAKLERKNLDLIVANDVSRPGAGFGSDTNEVT 183
PRK07313 PRK07313
phosphopantothenoylcysteine decarboxylase; Validated
 6-186 7.72e-49

phosphopantothenoylcysteine decarboxylase; Validated


Pssm-ID: 235986 [Multi-domain]  Cd Length: 182  Bit Score: 163.58  E-value: 7.72e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011   6 GKKIILGISAGIAAYKTPILVRLLKQKGAQVRVVLTPDAHAFVTPLTLSVVSEEEVLSSfvAEDKDNPVWNDHVALGLWA 85
Cdd:PRK07313    1 MKNILLAVSGSIAAYKAADLTSQLTKRGYQVTVLMTKAATKFITPLTLQVLSKNPVHLD--VMDEHDPKLMNHIELAKRA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011  86 DLLLIAPATANTLSAMAQAKSNNLLIATYLSA--RCPIMVAPAMDLDMYAHPANQKNLDTLASYGNQILPVGEGALASGL 163
Cdd:PRK07313   79 DLFLVAPATANTIAKLAHGIADDLVTSVALALpaTTPKLIAPAMNTKMYENPATQRNLKTLKEDGVQEIEPKEGLLACGD 158

                         170       180
                  ....*....|....*....|...
gi 1200388011 164 VGKGRLLEPDQIVERVIVHFNSA 186
Cdd:PRK07313  159 EGYGALADIETILETIENTLKEK 181
Flavoprotein pfam02441
Flavoprotein; This family contains diverse flavoprotein enzymes. This family includes ...
 7-183 6.11e-38

Flavoprotein; This family contains diverse flavoprotein enzymes. This family includes epidermin biosynthesis protein, EpiD, which has been shown to be a flavoprotein that binds FMN. This enzyme catalyzes the removal of two reducing equivalents from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C==C-- double bond. This family also includes the B chain of dipicolinate synthase a small polar molecule that accumulates to high concentrations in bacterial endospores, and is thought to play a role in spore heat resistance, or the maintenance of heat resistance. dipicolinate synthase catalyzes the formation of dipicolinic acid from dihydroxydipicolinic acid. This family also includes phenyl-acrylic acid decarboxylase (EC:4.1.1.-).


Pssm-ID: 426775 [Multi-domain]  Cd Length: 177  Bit Score: 134.81  E-value: 6.11e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011   7 KKIILGISAGIAAYKTPILVRLLKQKGAQVRVVLTPDAHAFVTPLTLSVVSEEEVLSSFVAEDKDNPVwndHVALGL--- 83
Cdd:pfam02441   1 KRILVGITGSSAAIKALRLLEELKKEGAEVRVIMTKAAKKVITPETLAALSENVDEDLTWRELDDDIL---HIELASgar 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011  84 WADLLLIAPATANTLSAMAQAKSNNLLIATY----------------LSARCPIMVAPAMDLDMYAHPANQKNLDTLASY 147
Cdd:pfam02441  78 WADAMVIAPASANTLAKIANGIADNLLTRAAdvalkerrphlenmltLTAKKPIIIAPAMNTAMYENPATLENLEDLKAD 157

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1200388011 148 GnqilpvgegalasglvGKGRLLEPDQIVERVIVHF 183
Cdd:pfam02441 158 G----------------GKGRMPEPEAIVGKVLDAL 177
PLN02496 PLN02496
probable phosphopantothenoylcysteine decarboxylase
 5-179 1.26e-16

probable phosphopantothenoylcysteine decarboxylase


Pssm-ID: 215274  Cd Length: 209  Bit Score: 78.09  E-value: 1.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011   5 RGKKIILGISAGIAAYKTPILVRLLKQkGAQVRVVLTPDAHAFVT----PLTLSVVSEEEVLSSfvaedkdnpvWND--- 77
Cdd:PLN02496   18 RKPRILLAASGSVAAIKFGNLCHCFSE-WAEVRAVVTKASLHFIDraslPKDVTLYTDEDEWSS----------WNKigd 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011  78 ---HVALGLWADLLLIAPATANTLSAMAQAKSNNLL--IATYLSARCPIMVAPAMDLDMYAHPANQKNLDTLASYGNQIL 152
Cdd:PLN02496   87 svlHIELRRWADVMVIAPLSANTLGKIAGGLCDNLLtcIVRAWDYSKPLFVAPAMNTFMWNNPFTERHLMSIDELGISLI 166

                         170       180
                  ....*....|....*....|....*..
gi 1200388011 153 PVGEGALASGLVGKGRLLEPDQIVERV 179
Cdd:PLN02496  167 PPVTKRLACGDYGNGAMAEPSLIYSTV 193
PRK06732 PRK06732
phosphopantothenate--cysteine ligase; Validated
 193-243 4.37e-11

phosphopantothenate--cysteine ligase; Validated


Pssm-ID: 235856 [Multi-domain]  Cd Length: 229  Bit Score: 62.31  E-value: 4.37e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1200388011 193 KVLITAGPTYEKIDPVRYIGNFSSGKMGYALAEEAHALGAEVYLILGPHAL 243
Cdd:PRK06732    2 KILITSGGTTEPIDSVRGITNHSTGQLGKIIAETFLAAGHEVTLVTTKTAV 52
PRK09620 PRK09620
hypothetical protein; Provisional
 189-393 1.94e-06

hypothetical protein; Provisional


Pssm-ID: 181997  Cd Length: 229  Bit Score: 48.35  E-value: 1.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 189 LSRKKVLITAGPTYEKIDPVRYIGNFSSGKMGYALAEEAHALGAEVYLILGPHA---LDLSNA----PF--------AVK 253
Cdd:PRK09620    1 MKGKKVLITSGGCLEKWDQVRGHTNMAKGTIGRIIAEELISKGAHVIYLHGYFAekpNDINNQlelhPFegiidlqdKMK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011 254 EVVSATEMETAVFKKfpTVDFAIAAAAVADFKPLAPKPHKIKKEEGiPSIELQPNPDILARMGKEKKQQFVLGFALETQD 333
Cdd:PRK09620   81 SIITHEKVDAVIMAA--AGSDWVVDKICDQEGNVLDMNGKISSDIA-PIIHFQKAPKVLKQIKQWDPETVLVGFKLESDV 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1200388011 334 NWKEAL--AKKRRKKADAIVM-----NSLTDPGAgfasdtnkITY-IGENEKPKRfsLKSKNEVAKDI 393
Cdd:PRK09620  158 NEEELFerAKNRMEEAKASVMianspHSLYSRGA--------MHYvIGQDGKGQL--CNGKDETAKEI 215
PRK05920 PRK05920
aromatic acid decarboxylase; Validated
 7-110 1.96e-03

aromatic acid decarboxylase; Validated


Pssm-ID: 180312  Cd Length: 204  Bit Score: 39.06  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200388011   7 KKIILGI---SAGIAAYKtpiLVRLLKQKGAQVRVVLTPDAH---AFVTPLTLSVVSE--EEVLSSFVAEDKDNPV---W 75
Cdd:PRK05920    4 KRIVLAItgaSGAIYGVR---LLECLLAADYEVHLVISKAAQkvlATETGLKLPAVPDlaEAFLREQLGAAAGQLRvhgK 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1200388011  76 NDH---VALGLWA-DLLLIAPATANTLSAMAQAKSNNLL 110
Cdd:PRK05920   81 DDWgapIASGSFRtDGMVIAPCSMGTLAAIAHGLSDNLI 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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