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Conserved domains on  [gi|1232315488|gb|OYV96577|]
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MAG: cytidylate kinase [Planctomycetia bacterium 21-64-5]

Protein Classification

(d)CMP kinase( domain architecture ID 10785233)

(d)CMP kinase catalyzes the phosphorylation of cytidine monophosphate (CMP) or dCMP to produce cytidine diphosphate (CDP) or dCDP, using ATP as the preferred phosphoryl donor

CATH:  3.40.50.300
Gene Ontology:  GO:0036431|GO:0006220|GO:0005524
PubMed:  10218107

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
1-216 2.64e-104

Cytidylate kinase [Nucleotide transport and metabolism];


:

Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 299.63  E-value: 2.64e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488   1 MIVAIDGPAGAGKSSAARALARRLGFRFLDTGAMYRAVALAGLRRHVDFSDMDAVAQMARQIALSL----DDDRVRLDGD 76
Cdd:COG0283     1 PVIAIDGPAGSGKSTVAKALAKRLGYHYLDTGAMYRAVALAALRNGIDLDDEEALAALARNLDIEFetdpGGQRVFLNGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488  77 DVTHEIRTLAVTSVTHYPANNAAVREHLVGLQRQFALGQNVVTEGRDQGTVVFPHAECKIFLTASPRERARRRHLDLKAH 156
Cdd:COG0283    81 DVTDEIRTEEVSNAVSKVAAIPEVREALVALQRAFAKAPGLVADGRDIGTVVFPDAELKIFLTASAEERARRRYKELKEK 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488 157 GEHVTLEEVLADQNERDLRDASRDVGPLKPAADAVTFNTDGLSAEEVVDRLEGLVRAKMA 216
Cdd:COG0283   161 GISVSLEELLADIKERDERDSTRAVAPLKPAEDAIVIDTTDLSIEEVVEKILALVRERLS 220
 
Name Accession Description Interval E-value
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
1-216 2.64e-104

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 299.63  E-value: 2.64e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488   1 MIVAIDGPAGAGKSSAARALARRLGFRFLDTGAMYRAVALAGLRRHVDFSDMDAVAQMARQIALSL----DDDRVRLDGD 76
Cdd:COG0283     1 PVIAIDGPAGSGKSTVAKALAKRLGYHYLDTGAMYRAVALAALRNGIDLDDEEALAALARNLDIEFetdpGGQRVFLNGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488  77 DVTHEIRTLAVTSVTHYPANNAAVREHLVGLQRQFALGQNVVTEGRDQGTVVFPHAECKIFLTASPRERARRRHLDLKAH 156
Cdd:COG0283    81 DVTDEIRTEEVSNAVSKVAAIPEVREALVALQRAFAKAPGLVADGRDIGTVVFPDAELKIFLTASAEERARRRYKELKEK 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488 157 GEHVTLEEVLADQNERDLRDASRDVGPLKPAADAVTFNTDGLSAEEVVDRLEGLVRAKMA 216
Cdd:COG0283   161 GISVSLEELLADIKERDERDSTRAVAPLKPAEDAIVIDTTDLSIEEVVEKILALVRERLS 220
Cytidylate_kin pfam02224
Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5 ...
 3-212 3.22e-83

Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP.


Pssm-ID: 280401 [Multi-domain]  Cd Length: 211  Bit Score: 246.06  E-value: 3.22e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488   3 VAIDGPAGAGKSSAARALARRLGFRFLDTGAMYRAVALAGLRRHVDFSDMDAVAQMARQIALSLDDDRVRLDGDDVTHEI 82
Cdd:pfam02224   1 IAIDGPSGSGKSTVARILARKLGYKYLDTGAMYRALALAALRQKVDLTDEDALAELASEVDISFGHTEVFLNGEDVSSEI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488  83 RTLAVTSVTHYPANNAAVREHLVGLQRQFALGQNVVTEGRDQGTVVFPHAECKIFLTASPRERARRRHLDLKAHGEHVTL 162
Cdd:pfam02224  81 RTDEVAQAASQVAAIPAVRARLNKLQRQLAKNGNIVMEGRDIGTVVFPDAEVKIFLTASPEERAKRRYKQLQAKGLSVDF 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1232315488 163 EEVLADQNERDLRDASRDVGPLKPAADAVTFNTDGLSAEEVVDRLEGLVR 212
Cdd:pfam02224 161 EELLAEIKRRDKRDSERAVGPLKPAPDALIIDTSKLTIEEVVEKILELIK 210
PRK13477 PRK13477
bifunctional pantoate--beta-alanine ligase/(d)CMP kinase;
2-214 4.72e-79

bifunctional pantoate--beta-alanine ligase/(d)CMP kinase;


Pssm-ID: 237393 [Multi-domain]  Cd Length: 512  Bit Score: 245.18  E-value: 4.72e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488   2 IVAIDGPAGAGKSSAARALARRLGFRFLDTGAMYRAVALAGLRRHVDFSDMDAVAQMARQIALSLDDD-----RVRLDGD 76
Cdd:PRK13477  286 IIAIDGPAGAGKSTVTRAVAKKLGLLYLDTGAMYRAVTWLVLQEGIDPQDEEALAELLSDLKIELKPSsgspqRVWINGE 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488  77 DVTHEIRTLAVTSVTHYPANNAAVREHLVGLQRQfaLGQN--VVTEGRDQGTVVFPHAECKIFLTASPRERARRRHLDLK 154
Cdd:PRK13477  366 DVTEAIRSPEVTSSVSAIAAQPAVRQALVKQQQR--IGEKggLVAEGRDIGTHVFPDAELKIFLTASVEERARRRALDLQ 443

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1232315488 155 AHG-EHVTLEEVLADQNERDLRDASRDVGPLKPAADAVTFNTDGLSAEEVVDRLEGLVRAK 214
Cdd:PRK13477  444 AQGfPVIDLEQLEAQIAERDRLDSTREIAPLRKADDAIELITDGLSIEEVVDKIIDLYRDR 504
cmk TIGR00017
cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the ...
 1-205 5.17e-73

cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5 -diphosphate (dCDP) in the presence of ATP or GTP. UMP and dCMP can also act as acceptors. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 129128 [Multi-domain]  Cd Length: 217  Bit Score: 220.38  E-value: 5.17e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488   1 MIVAIDGPAGAGKSSAARALARRLGFRFLDTGAMYRAVALAGLRRHVDFSDMDAVAQMARQIALSL----DDDRVRLDGD 76
Cdd:TIGR00017   3 MIIAIDGPSGAGKSTVAKAVAEKLGYAYLDSGAMYRAIALAALQNRVDLTSEDALAELISHLDIRFiptnGEVEVFLNGE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488  77 DVTHEIRTLAVTSVTHYPANNAAVREHLVGLQRQFALGQNVVTEGRDQGTVVFPHAECKIFLTASPRERARRRHLDLKAH 156
Cdd:TIGR00017  83 DVSEAIRTQEVANAASKVAVFPKVREALLKRQQALAKNDGIIADGRDIGTVVFPNAEVKIFLDASVEERAKRRYKQLQIK 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1232315488 157 GEHVTLEEVLADQNERDLRDASRDVGPLKPAADAVTFNTDGLSAEEVVD 205
Cdd:TIGR00017 163 GNEVNFEELLAEIKERDDRDSNREVAPLKKADDALYLDTSNLSIDEVVE 211
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 2-196 2.27e-54

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 170.36  E-value: 2.27e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488   2 IVAIDGPAGAGKSSAARALARRLGFRFLDTGamyravalaglrrhvdfsdmdavaqmarqialsldddrvrldgddvthE 81
Cdd:cd02020     1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTG------------------------------------------------G 32

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488  82 IRTLAVTSVTHYPANNAAVREHLVGLQRQFALGQNVVTEGRDQGTVVFPHAECKIFLTASPRERARRRHLDLKAHGEHVT 161
Cdd:cd02020    33 IRTEEVGKLASEVAAIPEVRKALDERQRELAKKPGIVLEGRDIGTVVFPDADLKIFLTASPEVRAKRRAKQLQAKGEGVD 112

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1232315488 162 LEEVLADQNERDLRDASRDVGPLKPAADAVTFNTD 196
Cdd:cd02020   113 LEEILAEIIERDERDSTRYVAPLKLAEDAIVIDTS 147
 
Name Accession Description Interval E-value
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
1-216 2.64e-104

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 299.63  E-value: 2.64e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488   1 MIVAIDGPAGAGKSSAARALARRLGFRFLDTGAMYRAVALAGLRRHVDFSDMDAVAQMARQIALSL----DDDRVRLDGD 76
Cdd:COG0283     1 PVIAIDGPAGSGKSTVAKALAKRLGYHYLDTGAMYRAVALAALRNGIDLDDEEALAALARNLDIEFetdpGGQRVFLNGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488  77 DVTHEIRTLAVTSVTHYPANNAAVREHLVGLQRQFALGQNVVTEGRDQGTVVFPHAECKIFLTASPRERARRRHLDLKAH 156
Cdd:COG0283    81 DVTDEIRTEEVSNAVSKVAAIPEVREALVALQRAFAKAPGLVADGRDIGTVVFPDAELKIFLTASAEERARRRYKELKEK 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488 157 GEHVTLEEVLADQNERDLRDASRDVGPLKPAADAVTFNTDGLSAEEVVDRLEGLVRAKMA 216
Cdd:COG0283   161 GISVSLEELLADIKERDERDSTRAVAPLKPAEDAIVIDTTDLSIEEVVEKILALVRERLS 220
Cytidylate_kin pfam02224
Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5 ...
 3-212 3.22e-83

Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP.


Pssm-ID: 280401 [Multi-domain]  Cd Length: 211  Bit Score: 246.06  E-value: 3.22e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488   3 VAIDGPAGAGKSSAARALARRLGFRFLDTGAMYRAVALAGLRRHVDFSDMDAVAQMARQIALSLDDDRVRLDGDDVTHEI 82
Cdd:pfam02224   1 IAIDGPSGSGKSTVARILARKLGYKYLDTGAMYRALALAALRQKVDLTDEDALAELASEVDISFGHTEVFLNGEDVSSEI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488  83 RTLAVTSVTHYPANNAAVREHLVGLQRQFALGQNVVTEGRDQGTVVFPHAECKIFLTASPRERARRRHLDLKAHGEHVTL 162
Cdd:pfam02224  81 RTDEVAQAASQVAAIPAVRARLNKLQRQLAKNGNIVMEGRDIGTVVFPDAEVKIFLTASPEERAKRRYKQLQAKGLSVDF 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1232315488 163 EEVLADQNERDLRDASRDVGPLKPAADAVTFNTDGLSAEEVVDRLEGLVR 212
Cdd:pfam02224 161 EELLAEIKRRDKRDSERAVGPLKPAPDALIIDTSKLTIEEVVEKILELIK 210
PRK13477 PRK13477
bifunctional pantoate--beta-alanine ligase/(d)CMP kinase;
2-214 4.72e-79

bifunctional pantoate--beta-alanine ligase/(d)CMP kinase;


Pssm-ID: 237393 [Multi-domain]  Cd Length: 512  Bit Score: 245.18  E-value: 4.72e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488   2 IVAIDGPAGAGKSSAARALARRLGFRFLDTGAMYRAVALAGLRRHVDFSDMDAVAQMARQIALSLDDD-----RVRLDGD 76
Cdd:PRK13477  286 IIAIDGPAGAGKSTVTRAVAKKLGLLYLDTGAMYRAVTWLVLQEGIDPQDEEALAELLSDLKIELKPSsgspqRVWINGE 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488  77 DVTHEIRTLAVTSVTHYPANNAAVREHLVGLQRQfaLGQN--VVTEGRDQGTVVFPHAECKIFLTASPRERARRRHLDLK 154
Cdd:PRK13477  366 DVTEAIRSPEVTSSVSAIAAQPAVRQALVKQQQR--IGEKggLVAEGRDIGTHVFPDAELKIFLTASVEERARRRALDLQ 443

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1232315488 155 AHG-EHVTLEEVLADQNERDLRDASRDVGPLKPAADAVTFNTDGLSAEEVVDRLEGLVRAK 214
Cdd:PRK13477  444 AQGfPVIDLEQLEAQIAERDRLDSTREIAPLRKADDAIELITDGLSIEEVVDKIIDLYRDR 504
cmk TIGR00017
cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the ...
 1-205 5.17e-73

cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5 -diphosphate (dCDP) in the presence of ATP or GTP. UMP and dCMP can also act as acceptors. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 129128 [Multi-domain]  Cd Length: 217  Bit Score: 220.38  E-value: 5.17e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488   1 MIVAIDGPAGAGKSSAARALARRLGFRFLDTGAMYRAVALAGLRRHVDFSDMDAVAQMARQIALSL----DDDRVRLDGD 76
Cdd:TIGR00017   3 MIIAIDGPSGAGKSTVAKAVAEKLGYAYLDSGAMYRAIALAALQNRVDLTSEDALAELISHLDIRFiptnGEVEVFLNGE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488  77 DVTHEIRTLAVTSVTHYPANNAAVREHLVGLQRQFALGQNVVTEGRDQGTVVFPHAECKIFLTASPRERARRRHLDLKAH 156
Cdd:TIGR00017  83 DVSEAIRTQEVANAASKVAVFPKVREALLKRQQALAKNDGIIADGRDIGTVVFPNAEVKIFLDASVEERAKRRYKQLQIK 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1232315488 157 GEHVTLEEVLADQNERDLRDASRDVGPLKPAADAVTFNTDGLSAEEVVD 205
Cdd:TIGR00017 163 GNEVNFEELLAEIKERDDRDSNREVAPLKKADDALYLDTSNLSIDEVVE 211
PRK11860 PRK11860
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
2-214 2.68e-61

bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;


Pssm-ID: 237003 [Multi-domain]  Cd Length: 661  Bit Score: 202.20  E-value: 2.68e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488   2 IVAIDGPAGAGKSSAARALARRLGFRFLDTGAMYRAVALAGLRRHVDFSDMDAVAQMARQIALSLDDDRVRLDGDDVTHE 81
Cdd:PRK11860  444 VICIDGPTASGKGTVAARVAEALGYHYLDSGALYRLTALAALRAGVALDDEAAIAALARGLPVRFEGDRIWLGGEDVTDA 523

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488  82 IRTLAVTSVTHYPANNAAVREHLVGLQRQFALGQNVVTEGRDQGTVVFPHAECKIFLTASPRERARRRHLDLKAHGEHVT 161
Cdd:PRK11860  524 IRTEAAGMGASRVSALPAVRAALLALQRSFRRLPGLVADGRDMGTVIFPDAALKVFLTASAEARAERRYKQLISKGISAN 603

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1232315488 162 LEEVLADQNERDLRDASRDVGPLKPAADAVTFNTDGLSAEEVVDRLEGLVRAK 214
Cdd:PRK11860  604 IADLLADLEARDARDTQRSVAPLKPAQDALLLDNSDLTIEQAVAQVLDWWQER 656
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 2-196 2.27e-54

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 170.36  E-value: 2.27e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488   2 IVAIDGPAGAGKSSAARALARRLGFRFLDTGamyravalaglrrhvdfsdmdavaqmarqialsldddrvrldgddvthE 81
Cdd:cd02020     1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTG------------------------------------------------G 32

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488  82 IRTLAVTSVTHYPANNAAVREHLVGLQRQFALGQNVVTEGRDQGTVVFPHAECKIFLTASPRERARRRHLDLKAHGEHVT 161
Cdd:cd02020    33 IRTEEVGKLASEVAAIPEVRKALDERQRELAKKPGIVLEGRDIGTVVFPDADLKIFLTASPEVRAKRRAKQLQAKGEGVD 112

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1232315488 162 LEEVLADQNERDLRDASRDVGPLKPAADAVTFNTD 196
Cdd:cd02020   113 LEEILAEIIERDERDSTRYVAPLKLAEDAIVIDTS 147
PRK09518 PRK09518
bifunctional cytidylate kinase/GTPase Der; Reviewed
 2-211 2.07e-46

bifunctional cytidylate kinase/GTPase Der; Reviewed


Pssm-ID: 236546 [Multi-domain]  Cd Length: 712  Bit Score: 162.66  E-value: 2.07e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488   2 IVAIDGPAGAGKSSAARALARRLGFRFLDTGAMYRAVALAGLRRHVDFSD--------MDAVAQMARQIALSLDDD---- 69
Cdd:PRK09518    3 IVAIDGPAGVGKSSVSRALAQYLGYAYLDTGAMYRACAWWCLKQGIDLDAelvdeqvvTEAVGEFFTGLHFDISVDpdsp 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488  70 RVRLDGDDVTHEIRTLAVTSVTHYPANNAAVREHLVGLQR----------QFALGQNVVTEGRDQGTVVFPHAECKIFLT 139
Cdd:PRK09518   83 GVFADGEDISEEIRSPEVSSHVSAVAAIPPVRNVLIAAQRayiareasadSFSGGLGIVAEGRDITTVVAPDAEVRILLT 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1232315488 140 ASPRERARRRHLDLKAhgehVTLEEVLADQNERDLRDaSRDVGPLKPAADAVTFNTDGLSAEEVVDRLEGLV 211
Cdd:PRK09518  163 AREEVRQARRSGQDRS----ETPGVVLEDVAARDEAD-SKVTSFLSAADGVTTLDNSDLDFDETLDLLIGLV 229
PRK12269 PRK12269
bifunctional cytidylate kinase/ribosomal protein S1; Provisional
 1-207 1.06e-27

bifunctional cytidylate kinase/ribosomal protein S1; Provisional


Pssm-ID: 105491 [Multi-domain]  Cd Length: 863  Bit Score: 109.80  E-value: 1.06e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488   1 MIVAIDGPAGAGKSSAARALARRLGFRFLDTGAMYRAVALAGLRR----------------------------HVDFSDM 52
Cdd:PRK12269   35 VIIALDGPAGSGKSSVCRLLASRLGAQCLNTGSFYRAFTLAALRRvselavqacspspdpdaavgcaavphatNLDTSYA 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488  53 DAVAQ-------------MARQIALSLDDDRVRLDGDDVTHEIRTLAVTSVTHYPANNAAVREHLVGLQRQFALGQNVVT 119
Cdd:PRK12269  115 PLTAQkkvalfdeaywvsFARTVALSYRAGVMYVGEENVESLLRSDEVESAVSYFAAMPAIRAIMTGKIRSAVCGARVVC 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488 120 EGRDQGTVVFPHAECKIFLTASPRERARRRHldlkAHG-EHVTLEEVLADQNERDLRDASRDVGPLKPAADAVTFNTDGL 198
Cdd:PRK12269  195 EGRDLTTVVFVDADLKCYLDASIEARVARRW----AQGtSRLSKQELEQRMRARDAHDRARTVGGLRCAPDALYVDTSCL 270


                  ....*....
gi 1232315488 199 SAEEVVDRL 207
Cdd:PRK12269  271 TIEEVCERI 279
CmkB COG1102
Cytidylate kinase [Nucleotide transport and metabolism];
1-216 9.46e-14

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440719 [Multi-domain]  Cd Length: 188  Bit Score: 66.77  E-value: 9.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488   1 MIVAIDGPAGAGKSSAARALARRLGFRFLDTgamyravalaglrrhvdfsdmDAVAQMARQIALSLDDdrvrldgddvTH 80
Cdd:COG1102     1 MVITISREPGSGGTTIAKRLAEKLGLPLYDG---------------------EILREAAKERGLSEEE----------FE 49

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488  81 EIRTLAVTSVTHYPANNAAVREHLVGLQRQFALGQNVVTEGRDQGTVVFPHAEC-KIFLTASPRERARRrhldlKAHGEH 159
Cdd:COG1102    50 KLDEKAPSLLYRDTAEEDEIDRALDKVIRELARKGNCVIVGRLADWILRDRPNVlKVFLTAPLEVRVKR-----IAEREG 124

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1232315488 160 VTLEEVLADQNERDLRDASR-------DVGplkpaaDA----VTFNTDGLSAEEVVDRLEGLVRAKMA 216
Cdd:COG1102   125 ISEEEAEKEIKKRDKSRAKYykyyygiDWG------DPsnydLVINTSRLGIEEAVDLILAAIEAREK 186
PRK04182 PRK04182
cytidylate kinase; Provisional
 1-205 1.87e-13

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 65.98  E-value: 1.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488   1 MIVAIDGPAGAGKSSAARALARRLGFRFLDTGAMYRAVALaglRRHVDFSDMDAVAQMARQIALSLDddrvrldgddvth 80
Cdd:PRK04182    1 MIITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRELAK---ERGMSLEEFNKYAEEDPEIDKEID------------- 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488  81 eirtlavtsvthypannaavrehlvglQRQFALGQ---NVVTEGRDQGTVVFPHAECKIFLTASPRERARR---Rhldlk 154
Cdd:PRK04182   65 ---------------------------RRQLEIAEkedNVVLEGRLAGWMAKDYADLKIWLKAPLEVRAERiaeR----- 112

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1232315488 155 ahgEHVTLEEVLADQNERDLRDASR-------DVGPLKPaADAVtFNTDGLSAEEVVD 205
Cdd:PRK04182  113 ---EGISVEEALEETIEREESEAKRykeyygiDIDDLSI-YDLV-INTSRWDPEGVFD 165
cyt_kin_arch TIGR02173
cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. ...
 1-173 6.88e-11

cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. Members of this family are found in the archaea and in spirochaetes, and differ considerably from the common bacterial form of cytidylate kinase described by TIGR00017.


Pssm-ID: 274012 [Multi-domain]  Cd Length: 171  Bit Score: 58.59  E-value: 6.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488   1 MIVAIDGPAGAGKSSAARALARRLGFRFLDTGAMYRavalaglrrhvdfsdmdavaQMARQIALSLDDdrvrldgddvth 80
Cdd:TIGR02173   1 MIITISGPPGSGKTTVAKILAEKLSLKLISAGDIFR--------------------ELAAKMGLDLIE------------ 48

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488  81 eirtlavtsVTHYPANNAAVREHLVGLQRQFALGQ-NVVTEGRDQGTVVFPHAECKIFLTASPRERARRrhldlKAHGEH 159
Cdd:TIGR02173  49 ---------FLNYAEENPEIDKKIDRRIHEIALKEkNVVLESRLAGWIVREYADVKIWLKAPLEVRARR-----IAKREG 114

                         170
                  ....*....|....
gi 1232315488 160 VTLEEVLADQNERD 173
Cdd:TIGR02173 115 KSLTVARSETIERE 128
Cytidylate_kin2 pfam13189
Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.
 2-148 1.92e-05

Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.


Pssm-ID: 433023 [Multi-domain]  Cd Length: 176  Bit Score: 43.39  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232315488   2 IVAIDGPAGAGKSSAARALARRLGFRFLDTGAMYRAVALAGLRRHVdfsdmdavaqmarqiaLSLDDDRVRLDGddvthE 81
Cdd:pfam13189   1 VITISRQYGSGGTTIAKKLAEKLGYPFYDREILDEIAKELGISEEE----------------FELFDEKSRLSS-----F 59

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1232315488  82 IRTLAVTSVTHYPANNAAVREHLVGLQRQFALGQNVVTEGRDQGTVVFPHAEC-KIFLTASPRERARR 148
Cdd:pfam13189  60 LYSLAGGRVRGDALSDDRLFDAQSKVIRELAAEDNCVIVGRGADYILKDIPNVlRVFLTAPLEDRVKR 127
aroK PRK00131
shikimate kinase; Reviewed
 7-31 2.38e-05

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 43.25  E-value: 2.38e-05
                          10        20
                  ....*....|....*....|....*
gi 1232315488   7 GPAGAGKSSAARALARRLGFRFLDT 31
Cdd:PRK00131   11 GFMGAGKSTIGRLLAKRLGYDFIDT 35
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 7-31 6.69e-05

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 41.65  E-value: 6.69e-05
                          10        20
                  ....*....|....*....|....*
gi 1232315488   7 GPAGAGKSSAARALARRLGFRFLDT 31
Cdd:COG0703     5 GMMGAGKSTVGRLLAKRLGLPFVDT 29
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 7-31 1.11e-04

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 41.00  E-value: 1.11e-04
                          10        20
                  ....*....|....*....|....*
gi 1232315488   7 GPAGAGKSSAARALARRLGFRFLDT 31
Cdd:cd00464     6 GMMGAGKTTVGRLLAKALGLPFVDL 30
PRK06547 PRK06547
hypothetical protein; Provisional
 1-27 1.34e-04

hypothetical protein; Provisional


Pssm-ID: 235825  Cd Length: 172  Bit Score: 40.88  E-value: 1.34e-04
                          10        20
                  ....*....|....*....|....*..
gi 1232315488   1 MIVAIDGPAGAGKSSAARALARRLGFR 27
Cdd:PRK06547   16 ITVLIDGRSGSGKTTLAGALAARTGFQ 42
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 2-70 2.29e-04

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 39.93  E-value: 2.29e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1232315488   2 IVAIDGPAGAGKSSAARALARRLGFRFLDTGamyravalaglrrhvDFSDMDAVAQMARQIALSlDDDR 70
Cdd:cd02021     1 IIVVMGVSGSGKSTVGKALAERLGAPFIDGD---------------DLHPPANIAKMAAGIPLN-DEDR 53
GntK COG3265
Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the ...
 1-70 2.70e-04

Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442496 [Multi-domain]  Cd Length: 164  Bit Score: 40.11  E-value: 2.70e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1232315488   1 MIVAIDGPAGAGKSSAARALARRLGFRFLD-----TGAMyravalaglrrhvdfsdmdaVAQMARQIALSlDDDR 70
Cdd:COG3265     2 MVIVVMGVSGSGKSTVGQALAERLGWPFIDgddfhPPAN--------------------IAKMAAGIPLT-DEDR 55
AAA_17 pfam13207
AAA domain;
7-75 7.70e-04

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 38.37  E-value: 7.70e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1232315488   7 GPAGAGKSSAARALARRLGFRFLDTGAMYRAVA----LAGLR---RHVDFSDMDAVAQMA-RQIALSLDDDRVRLDG 75
Cdd:pfam13207   2 GVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAkergLVEDRdemRKLPLEPQKELQKLAaERIAEEAGEGGVIVDG 78
aroL PRK03731
shikimate kinase AroL;
7-34 9.98e-04

shikimate kinase AroL;


Pssm-ID: 235153 [Multi-domain]  Cd Length: 171  Bit Score: 38.38  E-value: 9.98e-04
                          10        20
                  ....*....|....*....|....*...
gi 1232315488   7 GPAGAGKSSAARALARRLGFRFLDTGAM 34
Cdd:PRK03731    9 GARGCGKTTVGMALAQALGYRFVDTDQW 36
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
2-63 1.26e-03

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 37.97  E-value: 1.26e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1232315488   2 IVAIDGPAGAGKSSAARALARRLGFRFLDTGAMYRAVALAGLRRHVDFSDM-----DAVAQMARQIA 63
Cdd:COG0645     1 LILVCGLPGSGKSTLARALAERLGAVRLRSDVVRKRLFGAGLAPLERSPEAtartyARLLALARELL 67
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 1-25 1.42e-03

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 38.28  E-value: 1.42e-03
                          10        20
                  ....*....|....*....|....*
gi 1232315488   1 MIVAIDGPAGAGKSSAARALARRLG 25
Cdd:COG0572     8 RIIGIAGPSGSGKTTFARRLAEQLG 32
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 7-68 2.29e-03

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 37.13  E-value: 2.29e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1232315488   7 GPAGAGKSSAARALARRL---GFRF--LDTGAMYRAVALAGLRRHVDFSDMDAVAQMARQIALSLDD 68
Cdd:cd00009    26 GPPGTGKTTLARAIANELfrpGAPFlyLNASDLLEGLVVAELFGHFLVRLLFELAEKAKPGVLFIDE 92
dNK cd01673
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to ...
 2-29 2.72e-03

Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.


Pssm-ID: 238836  Cd Length: 193  Bit Score: 37.59  E-value: 2.72e-03
                          10        20
                  ....*....|....*....|....*...
gi 1232315488   2 IVAIDGPAGAGKSSAARALARRLGFRFL 29
Cdd:cd01673     1 VIVVEGNIGAGKSTLAKELAEHLGYEVV 28
PRK03839 PRK03839
putative kinase; Provisional
 1-75 2.91e-03

putative kinase; Provisional


Pssm-ID: 179660  Cd Length: 180  Bit Score: 37.39  E-value: 2.91e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1232315488   1 MIVAIDGPAGAGKSSAARALARRLGFRFLDTgamyRAVALA-GLRRHVDfSDMDA-VAQMARQIALSLDDDRVRLDG 75
Cdd:PRK03839    1 MIIAITGTPGVGKTTVSKLLAEKLGYEYVDL----TEFALKkGIGEEKD-DEMEIdFDKLAYFIEEEFKEKNVVLDG 72
SKI pfam01202
Shikimate kinase;
10-31 4.62e-03

Shikimate kinase;


Pssm-ID: 426122 [Multi-domain]  Cd Length: 159  Bit Score: 36.41  E-value: 4.62e-03
                          10        20
                  ....*....|....*....|..
gi 1232315488  10 GAGKSSAARALARRLGFRFLDT 31
Cdd:pfam01202   2 GAGKSTIGRLLAKALGLPFIDT 23
NK cd02019
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 2-27 7.19e-03

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


Pssm-ID: 238977 [Multi-domain]  Cd Length: 69  Bit Score: 34.23  E-value: 7.19e-03
                          10        20
                  ....*....|....*....|....*.
gi 1232315488   2 IVAIDGPAGAGKSSAARALARRLGFR 27
Cdd:cd02019     1 IIAITGGSGSGKSTVAKKLAEQLGGR 26
ABCC_ATM1_transporter cd03253
ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; ATM1 is an ABC ...
 3-47 9.15e-03

ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to mitochondrial DNA, and decreased levels of cytosolic heme proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213220 [Multi-domain]  Cd Length: 236  Bit Score: 36.05  E-value: 9.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1232315488   3 VAIDGPAGAGKSSAARALarrlgFRFLD--TGAMY------RAVALAGLRRHV 47
Cdd:cd03253    30 VAIVGPSGSGKSTILRLL-----FRFYDvsSGSILidgqdiREVTLDSLRRAI 77
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1-42 9.19e-03

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 35.87  E-value: 9.19e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1232315488   1 MIVAIDGPAGAGKSSAARALARRLGFRFLDTGAMYRAVALAG 42
Cdd:COG0563     1 MRIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAG 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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