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Conserved domains on  [gi|1232994000|gb|OZB89957.1|]
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Holliday junction branch migration protein RuvA, partial [Microbacterium sp. 14-71-5]

Protein Classification

Holliday junction ATP-dependent DNA helicase RuvA( domain architecture ID 11428141)

Holliday junction ATP-dependent DNA helicase RuvA is involved in branch migration of heteroduplex DNA in homologous recombination by stimulating the ATPase activity of RuvB

CATH:  1.10.150.20
EC:  3.6.4.12
Gene Ontology:  GO:0009378|GO:0003677|GO:0016887|GO:0005524|GO:0006281|GO:0006310
SCOP:  4000746|4001893|4001026

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RuvA COG0632
Holliday junction resolvasome RuvABC DNA-binding subunit [Replication, recombination and ...
 1-81 5.74e-32

Holliday junction resolvasome RuvABC DNA-binding subunit [Replication, recombination and repair];


:

Pssm-ID: 440397 [Multi-domain]  Cd Length: 195  Bit Score: 109.46  E-value: 5.74e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232994000   1 MISSLRGTVLSASTDSVIIEVGGVGFSVAVPGDV-AHTARVGHELRLHTSLIVREDALSLYGFADAAELEVFGHLISVTG 79
Cdd:COG0632     1 MIAYLRGTLVEKGPDYVVIDVGGVGYEVFVPLSTlSALPEVGEEVKLYTHLVVREDALTLYGFATEEERELFRLLISVSG 80


                  ..
gi 1232994000  80 VG 81
Cdd:COG0632    81 VG 82
 
Name Accession Description Interval E-value
RuvA COG0632
Holliday junction resolvasome RuvABC DNA-binding subunit [Replication, recombination and ...
 1-81 5.74e-32

Holliday junction resolvasome RuvABC DNA-binding subunit [Replication, recombination and repair];


Pssm-ID: 440397 [Multi-domain]  Cd Length: 195  Bit Score: 109.46  E-value: 5.74e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232994000   1 MISSLRGTVLSASTDSVIIEVGGVGFSVAVPGDV-AHTARVGHELRLHTSLIVREDALSLYGFADAAELEVFGHLISVTG 79
Cdd:COG0632     1 MIAYLRGTLVEKGPDYVVIDVGGVGYEVFVPLSTlSALPEVGEEVKLYTHLVVREDALTLYGFATEEERELFRLLISVSG 80


                  ..
gi 1232994000  80 VG 81
Cdd:COG0632    81 VG 82
ruvA PRK00116
Holliday junction branch migration protein RuvA;
1-81 2.15e-29

Holliday junction branch migration protein RuvA;


Pssm-ID: 234645 [Multi-domain]  Cd Length: 192  Bit Score: 102.91  E-value: 2.15e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232994000   1 MISSLRGTVLSASTDSVIIEVGGVGFSVAVPG-DVAHTARVGHELRLHTSLIVREDALSLYGFADAAELEVFGHLISVTG 79
Cdd:PRK00116    1 MIGYLKGKLVEKGPDYVVIEVNGVGYEVQVPMrTLYELPEVGEEVKLYTHLVVREDAILLYGFLTKEERELFRLLISVSG 80


                  ..
gi 1232994000  80 VG 81
Cdd:PRK00116   81 VG 82
RuvA_N pfam01330
RuvA N terminal domain; The N terminal domain of RuvA has an OB-fold structure. This domain ...
 1-61 5.07e-22

RuvA N terminal domain; The N terminal domain of RuvA has an OB-fold structure. This domain forms the RuvA tetramer contacts.


Pssm-ID: 460162 [Multi-domain]  Cd Length: 61  Bit Score: 80.16  E-value: 5.07e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1232994000  1 MISSLRGTVLSASTDSVIIEVGGVGFSVAVPGDVAHTARVGHELRLHTSLIVREDALSLYG 61
Cdd:pfam01330  1 MIAYLKGTVVEKGPDYVVIDVGGVGYEVFISLSTLSKLAVGEEVKLYTHLVVREDALTLYG 61
ruvA TIGR00084
Holliday junction DNA helicase, RuvA subunit; RuvA specifically binds Holliday junctions as a ...
 1-81 1.01e-19

Holliday junction DNA helicase, RuvA subunit; RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129193 [Multi-domain]  Cd Length: 191  Bit Score: 78.18  E-value: 1.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232994000   1 MISSLRGTVLSASTDSVIIEVGGVGFSVAVPGDVAHTARVGHELRLHTSLIVREDALSLYGFADAAELEVFGHLISVTGV 80
Cdd:TIGR00084   1 MIGFLFGKVIEVSKPKIIIEVNGVGYELQVPMTCAYELNLEQKAQVFTHLVVREDAELLFGFNTLEERELFKELIKVNGV 80


                  .
gi 1232994000  81 G 81
Cdd:TIGR00084  81 G 81
 
Name Accession Description Interval E-value
RuvA COG0632
Holliday junction resolvasome RuvABC DNA-binding subunit [Replication, recombination and ...
 1-81 5.74e-32

Holliday junction resolvasome RuvABC DNA-binding subunit [Replication, recombination and repair];


Pssm-ID: 440397 [Multi-domain]  Cd Length: 195  Bit Score: 109.46  E-value: 5.74e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232994000   1 MISSLRGTVLSASTDSVIIEVGGVGFSVAVPGDV-AHTARVGHELRLHTSLIVREDALSLYGFADAAELEVFGHLISVTG 79
Cdd:COG0632     1 MIAYLRGTLVEKGPDYVVIDVGGVGYEVFVPLSTlSALPEVGEEVKLYTHLVVREDALTLYGFATEEERELFRLLISVSG 80


                  ..
gi 1232994000  80 VG 81
Cdd:COG0632    81 VG 82
ruvA PRK00116
Holliday junction branch migration protein RuvA;
1-81 2.15e-29

Holliday junction branch migration protein RuvA;


Pssm-ID: 234645 [Multi-domain]  Cd Length: 192  Bit Score: 102.91  E-value: 2.15e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232994000   1 MISSLRGTVLSASTDSVIIEVGGVGFSVAVPG-DVAHTARVGHELRLHTSLIVREDALSLYGFADAAELEVFGHLISVTG 79
Cdd:PRK00116    1 MIGYLKGKLVEKGPDYVVIEVNGVGYEVQVPMrTLYELPEVGEEVKLYTHLVVREDAILLYGFLTKEERELFRLLISVSG 80


                  ..
gi 1232994000  80 VG 81
Cdd:PRK00116   81 VG 82
RuvA_N pfam01330
RuvA N terminal domain; The N terminal domain of RuvA has an OB-fold structure. This domain ...
 1-61 5.07e-22

RuvA N terminal domain; The N terminal domain of RuvA has an OB-fold structure. This domain forms the RuvA tetramer contacts.


Pssm-ID: 460162 [Multi-domain]  Cd Length: 61  Bit Score: 80.16  E-value: 5.07e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1232994000  1 MISSLRGTVLSASTDSVIIEVGGVGFSVAVPGDVAHTARVGHELRLHTSLIVREDALSLYG 61
Cdd:pfam01330  1 MIAYLKGTVVEKGPDYVVIDVGGVGYEVFISLSTLSKLAVGEEVKLYTHLVVREDALTLYG 61
ruvA TIGR00084
Holliday junction DNA helicase, RuvA subunit; RuvA specifically binds Holliday junctions as a ...
 1-81 1.01e-19

Holliday junction DNA helicase, RuvA subunit; RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129193 [Multi-domain]  Cd Length: 191  Bit Score: 78.18  E-value: 1.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232994000   1 MISSLRGTVLSASTDSVIIEVGGVGFSVAVPGDVAHTARVGHELRLHTSLIVREDALSLYGFADAAELEVFGHLISVTGV 80
Cdd:TIGR00084   1 MIGFLFGKVIEVSKPKIIIEVNGVGYELQVPMTCAYELNLEQKAQVFTHLVVREDAELLFGFNTLEERELFKELIKVNGV 80


                  .
gi 1232994000  81 G 81
Cdd:TIGR00084  81 G 81
ruvA PRK14600
Holliday junction branch migration protein RuvA;
1-80 3.92e-11

Holliday junction branch migration protein RuvA;


Pssm-ID: 173064 [Multi-domain]  Cd Length: 186  Bit Score: 55.52  E-value: 3.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1232994000   1 MISSLRGTVLSASTDSVIIEVGGVGFSVAVPGDVAHTARVGHELRLHTSLIV-REDALSLYGFADAAELEVFGHLISVTG 79
Cdd:PRK14600    1 MIGSLSGIVEEVRSDYIILNVGNVGYIVYLSAKVLSTCKIGDNIKLYIETYVnRDNVTQLYGFLNREEQDCLRMLVKVSG 80


                  .
gi 1232994000  80 V 80
Cdd:PRK14600   81 V 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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