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Conserved domains on  [gi|2507357|sp|P02740|]
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RecName: Full=Serum amyloid A protein; Short=SAA; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAA super family cl02506
Serum amyloid A protein; The serum amyloid A (SAA) proteins comprise a family of vertebrate ...
 25-127 1.39e-62

Serum amyloid A protein; The serum amyloid A (SAA) proteins comprise a family of vertebrate amphipathic alpha-helical apolipoproteins that associate predominantly with high density lipoproteins (HDL). They play a role in the mobilization of cholesterol for tissue repair and regeneration. The synthesis of these proteins is greatly increased (as much as a 1000 fold) in inflammation, being a major acute phase reactant together with C-reactive protein. They act as cytokine-like proteins that are involved in cell-cell communication and in inflammatory, immunologic, neoplastic and protective pathways. Prolonged elevation of plasma SAA levels, as in chronic inflammation, results in a pathological condition, called amyloidosis, which is characterized by the highly insoluble accumulation of SAA in several tissues. During chronic inflammation, SAA association with HDL can change its protein and lipid composition which abrogates the HDL anti-atherogenic properties, contributing to a pro-atherogenic state.


The actual alignment was detected with superfamily member smart00197:

Pssm-ID: 470594  Cd Length: 103  Bit Score: 186.18  E-value: 1.39e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507357      25 GGRFVLDAAGGAWDMLRAYRDMREANHIGADKYFHARGNYDAARRGPGGAWAARVISDARENWQGGVSGRGAEDTRADQE 104
Cdd:smart00197   1 WRSFFKEALQGAWDMWRAYRDMKEANHQNADKYFHARGNYDAAQRGPGGVWAAKVISDAREYFQGLISGRGLEDSKADQK 80

                           90       100
                   ....*....|....*....|...
gi 2507357     105 ANAWGRNGGDPNRYRPPGLPSKY 127
Cdd:smart00197  81 ANEWGRSGKDPNRFRPPGLPEKY 103
 
Name Accession Description Interval E-value
SAA smart00197
Serum amyloid A proteins; Serum amyloid A proteins are induced during the acute-phase response. ...
 25-127 1.39e-62

Serum amyloid A proteins; Serum amyloid A proteins are induced during the acute-phase response. Secondary amyloidosis is characterised by the extracellular accumulation in tissues of SAA proteins. SAA proteins are apolipoproteins.


Pssm-ID: 214552  Cd Length: 103  Bit Score: 186.18  E-value: 1.39e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507357      25 GGRFVLDAAGGAWDMLRAYRDMREANHIGADKYFHARGNYDAARRGPGGAWAARVISDARENWQGGVSGRGAEDTRADQE 104
Cdd:smart00197   1 WRSFFKEALQGAWDMWRAYRDMKEANHQNADKYFHARGNYDAAQRGPGGVWAAKVISDAREYFQGLISGRGLEDSKADQK 80

                           90       100
                   ....*....|....*....|...
gi 2507357     105 ANAWGRNGGDPNRYRPPGLPSKY 127
Cdd:smart00197  81 ANEWGRSGKDPNRFRPPGLPEKY 103
SAA pfam00277
Serum amyloid A protein; The serum amyloid A (SAA) proteins comprise a family of vertebrate ...
 27-127 1.80e-59

Serum amyloid A protein; The serum amyloid A (SAA) proteins comprise a family of vertebrate amphipathic alpha-helical apolipoproteins that associate predominantly with high density lipoproteins (HDL). They play a role in the mobilization of cholesterol for tissue repair and regeneration. The synthesis of these proteins is greatly increased (as much as a 1000 fold) in inflammation, being a major acute phase reactant together with C-reactive protein. They act as cytokine-like proteins that are involved in cell-cell communication and in inflammatory, immunologic, neoplastic and protective pathways. Prolonged elevation of plasma SAA levels, as in chronic inflammation, results in a pathological condition, called amyloidosis, which is characterized by the highly insoluble accumulation of SAA in several tissues. During chronic inflammation, SAA association with HDL can change its protein and lipid composition which abrogates the HDL anti-atherogenic properties, contributing to a pro-atherogenic state.


Pssm-ID: 459744  Cd Length: 102  Bit Score: 178.29  E-value: 1.80e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507357     27 RFVLDAAGGAWDMLRAYRDMREANHIGADKYFHARGNYDAARRGPGGAWAARVISDARENWQGGVSGRGAEDTRADQEAN 106
Cdd:pfam00277   2 SFFKEAAQGAGDMWRAYWDMREANYKNSDKYFHARGNYDAAQRGPGGVWAAKVISDAREYLQGHVSGRGLEDSAADQEAN 81

                          90       100
                  ....*....|....*....|.
gi 2507357    107 AWGRNGGDPNRYRPPGLPSKY 127
Cdd:pfam00277  82 EWGRSGKDPNHFRPRGLPDKY 102
 
Name Accession Description Interval E-value
SAA smart00197
Serum amyloid A proteins; Serum amyloid A proteins are induced during the acute-phase response. ...
 25-127 1.39e-62

Serum amyloid A proteins; Serum amyloid A proteins are induced during the acute-phase response. Secondary amyloidosis is characterised by the extracellular accumulation in tissues of SAA proteins. SAA proteins are apolipoproteins.


Pssm-ID: 214552  Cd Length: 103  Bit Score: 186.18  E-value: 1.39e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507357      25 GGRFVLDAAGGAWDMLRAYRDMREANHIGADKYFHARGNYDAARRGPGGAWAARVISDARENWQGGVSGRGAEDTRADQE 104
Cdd:smart00197   1 WRSFFKEALQGAWDMWRAYRDMKEANHQNADKYFHARGNYDAAQRGPGGVWAAKVISDAREYFQGLISGRGLEDSKADQK 80

                           90       100
                   ....*....|....*....|...
gi 2507357     105 ANAWGRNGGDPNRYRPPGLPSKY 127
Cdd:smart00197  81 ANEWGRSGKDPNRFRPPGLPEKY 103
SAA pfam00277
Serum amyloid A protein; The serum amyloid A (SAA) proteins comprise a family of vertebrate ...
 27-127 1.80e-59

Serum amyloid A protein; The serum amyloid A (SAA) proteins comprise a family of vertebrate amphipathic alpha-helical apolipoproteins that associate predominantly with high density lipoproteins (HDL). They play a role in the mobilization of cholesterol for tissue repair and regeneration. The synthesis of these proteins is greatly increased (as much as a 1000 fold) in inflammation, being a major acute phase reactant together with C-reactive protein. They act as cytokine-like proteins that are involved in cell-cell communication and in inflammatory, immunologic, neoplastic and protective pathways. Prolonged elevation of plasma SAA levels, as in chronic inflammation, results in a pathological condition, called amyloidosis, which is characterized by the highly insoluble accumulation of SAA in several tissues. During chronic inflammation, SAA association with HDL can change its protein and lipid composition which abrogates the HDL anti-atherogenic properties, contributing to a pro-atherogenic state.


Pssm-ID: 459744  Cd Length: 102  Bit Score: 178.29  E-value: 1.80e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2507357     27 RFVLDAAGGAWDMLRAYRDMREANHIGADKYFHARGNYDAARRGPGGAWAARVISDARENWQGGVSGRGAEDTRADQEAN 106
Cdd:pfam00277   2 SFFKEAAQGAGDMWRAYWDMREANYKNSDKYFHARGNYDAAQRGPGGVWAAKVISDAREYLQGHVSGRGLEDSAADQEAN 81

                          90       100
                  ....*....|....*....|.
gi 2507357    107 AWGRNGGDPNRYRPPGLPSKY 127
Cdd:pfam00277  82 EWGRSGKDPNHFRPRGLPDKY 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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