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Conserved domains on  [gi|121532|sp|P13224|]
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RecName: Full=Platelet glycoprotein Ib beta chain; Short=GP-Ib beta; Short=GPIb-beta; Short=GPIbB; AltName: Full=Antigen CD42b-beta; AltName: CD_antigen=CD42c; Flags: Precursor

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 10635600)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRRCT smart00082
Leucine rich repeat C-terminal domain;
89-135 2.52e-08

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 2.52e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 121532       89 NPWRCDCRLVPLRAWLAGRPERAPYRDLRCVAPPALRGRLLPYLAED 135
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSE 47
LRRNT smart00013
Leucine rich repeat N-terminal domain;
25-59 3.00e-05

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 39.61  E-value: 3.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 121532       25 GCPAPCSCAGTLVDCGRRGLTwaSLPTAFPVDTTE 59
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLT--EVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRRCT smart00082
Leucine rich repeat C-terminal domain;
89-135 2.52e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 2.52e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 121532       89 NPWRCDCRLVPLRAWLAGRPERAPYRDLRCVAPPALRGRLLPYLAED 135
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSE 47
LRRNT smart00013
Leucine rich repeat N-terminal domain;
25-59 3.00e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 39.61  E-value: 3.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 121532       25 GCPAPCSCAGTLVDCGRRGLTwaSLPTAFPVDTTE 59
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLT--EVPLDLPPDTTL 33
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 62-143 2.01e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 41.61  E-value: 2.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121532       62 LTGNNLTALPPGLLDALPALRTAHLGANPWRCDCRLVPLRAWL------AGRPERApyrdlRCVAPPALRGRLL---PYL 132
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAeekgvkVRQPEAA-----LCAGPGALAGQPLlgiPLL 76

                           90
                   ....*....|...
gi 121532      133 AE--DELRAACAP 143
Cdd:TIGR00864   77 DSgcDEEYVACLK 89
 
Name Accession Description Interval E-value
LRRCT smart00082
Leucine rich repeat C-terminal domain;
89-135 2.52e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 2.52e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 121532       89 NPWRCDCRLVPLRAWLAGRPERAPYRDLRCVAPPALRGRLLPYLAED 135
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSE 47
LRRNT smart00013
Leucine rich repeat N-terminal domain;
25-59 3.00e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 39.61  E-value: 3.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 121532       25 GCPAPCSCAGTLVDCGRRGLTwaSLPTAFPVDTTE 59
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLT--EVPLDLPPDTTL 33
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 62-143 2.01e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 41.61  E-value: 2.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121532       62 LTGNNLTALPPGLLDALPALRTAHLGANPWRCDCRLVPLRAWL------AGRPERApyrdlRCVAPPALRGRLL---PYL 132
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAeekgvkVRQPEAA-----LCAGPGALAGQPLlgiPLL 76

                           90
                   ....*....|...
gi 121532      133 AE--DELRAACAP 143
Cdd:TIGR00864   77 DSgcDEEYVACLK 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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