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Conserved domains on  [gi|584910|sp|P18063|]
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RecName: Full=G2/mitotic-specific cyclin-B

Protein Classification

G2/mitotic-specific cyclin-B( domain architecture ID 15334103)

G2/mitotic-specific cyclin-B is essential for the control of the cell cycle at the G2/M (mitosis) transition

Gene Ontology:  GO:0051301|GO:0007049

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 141-267 7.39e-77

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 233.58  E-value: 7.39e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   141 CSEYVNDIYLYMRHLEREFKVRTDYMAMQ-EITERMRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQ 219
Cdd:cd20507   1 VSEYVKDIYKYLRQLEKKYAIDPDYLSGQpEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQ 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 584910   220 LVGVTSMLIAA-YEEMYA-EIGDFVYITDNAYSKAQIRAMECNILRKLDF 267
Cdd:cd20507  81 LVGVTALLIASkYEEIYPpEIKDFVYITDNAYTREEILQMERDILKTLDF 130
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 272-382 1.00e-48

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410213  Cd Length: 111  Bit Score: 160.47  E-value: 1.00e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   272 PLCIHFLRRCSKAGGVDGHKHTLSKYIMELTL*EYSFVKY-D*EIAAAALLSTRFWDEDMEWTKSLVHYSAYSEGHLGPI 350
Cdd:cd20509   1 PLPLHFLRRFSKAGGADAQKHTLAKYLMELTLLDYDMVHYkPSEIAAAALCLSRKILDEPEWTPTLEHYSTYSEEDLLPI 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 584910   351 VQKMAVLSQQSHpsPNSRLDQEEDMASSKFMS 382
Cdd:cd20509  81 VQKMAKLVVKSQ--TSKYQAVKNKYSSSKFMR 110
 
Name Accession Description Interval E-value
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 141-267 7.39e-77

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 233.58  E-value: 7.39e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   141 CSEYVNDIYLYMRHLEREFKVRTDYMAMQ-EITERMRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQ 219
Cdd:cd20507   1 VSEYVKDIYKYLRQLEKKYAIDPDYLSGQpEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQ 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 584910   220 LVGVTSMLIAA-YEEMYA-EIGDFVYITDNAYSKAQIRAMECNILRKLDF 267
Cdd:cd20507  81 LVGVTALLIASkYEEIYPpEIKDFVYITDNAYTREEILQMERDILKTLDF 130
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
97-354 1.40e-50

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 175.73  E-value: 1.40e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910    97 VEKVQSPEPMDMSEVSNALEAFSQNILEMGVDDIDKDDHENPQLCSEYVNDIYLYMRHLEREFKVRTDYMAMQEITE-RM 175
Cdd:COG5024 133 DENSLSPYELDENQLALDEKQAESKRESQSWQDLDATDQEDPLMVPEYASDIFEYLLKLELIDLPNPNYLIKQSLYEwSM 212

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   176 RTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQLVGVTSMLIAA-YEEMYAE-IGDFVYITDNAYSKAQ 253
Cdd:COG5024 213 RSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASkYEEVNCPsIKDLVYATDGAFTRDD 292

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   254 IRAMECNILRKLDFNLGKPLCIHFLRRCSKAGGVDGHKHTLSKYIMELTL*EYSFVKYD*EI--AAAALLSTRFWDEDmE 331
Cdd:COG5024 293 IIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSRTPAKFSSEISPVDYKFIQISPSWcaAAAMYLSRKILSQN-Q 371

                       250       260
                ....*....|....*....|....
gi 584910   332 WTKSLVHYS-AYSEGHLGPIVQKM 354
Cdd:COG5024 372 WDRTLIHYSgNYTNPDLKPLNESN 395
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 147-270 1.51e-49

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 163.46  E-value: 1.51e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910     147 DIYLYMRHLEREFKVRTDYMAMQ-EITERMRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQLVGVTS 225
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQpDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 584910     226 MLIAA-YEEMYA-EIGDFVYITDNAYSKAQIRAMECNILRKLDFNLG 270
Cdd:pfam00134  81 LFIAAkYEEIYPpTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 272-382 1.00e-48

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 160.47  E-value: 1.00e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   272 PLCIHFLRRCSKAGGVDGHKHTLSKYIMELTL*EYSFVKY-D*EIAAAALLSTRFWDEDMEWTKSLVHYSAYSEGHLGPI 350
Cdd:cd20509   1 PLPLHFLRRFSKAGGADAQKHTLAKYLMELTLLDYDMVHYkPSEIAAAALCLSRKILDEPEWTPTLEHYSTYSEEDLLPI 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 584910   351 VQKMAVLSQQSHpsPNSRLDQEEDMASSKFMS 382
Cdd:cd20509  81 VQKMAKLVVKSQ--TSKYQAVKNKYSSSKFMR 110
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 272-382 4.59e-24

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 95.77  E-value: 4.59e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910     272 PLCIHFLRRCSKAGGV--DGHKHTLSKYIMELTL*EYSFVKYD*-EIAAAALLSTRFWDEDMEWTKSLVHYSAYSEGHLG 348
Cdd:pfam02984   1 PTPLSFLRRFSKAADYlhDLELRTLAKYLLELTLLDYDFLKYPPsLIAAAAVYLARKTLNSPEWTETLEHYTGYSEEDLK 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 584910     349 PIVQKMAVLSQQshpSPNSRLDQ-EEDMASSKFMS 382
Cdd:pfam02984  81 PCVKLLLELLLN---APSSKLQAvRRKYSSSKFMK 112
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 181-263 2.34e-13

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 64.92  E-value: 2.34e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910      181 DWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQLVGVTSMLIAA-YEEMYAEIGDFVYITDNaYSKAQIRAMEC 259
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASkTEETPPWTKELVHYTGY-FTEEEILRMER 79


                   ....
gi 584910      260 NILR 263
Cdd:smart00385  80 LLLE 83
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 276-354 1.23e-09

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 54.52  E-value: 1.23e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910      276 HFLRRCSKAGGVDGHKHTLSKYIMELTL*EYSFVKYD*E-IAAAAL-LSTRFWDEDmEWTKSLVHYSAY-SEGHLGPIVQ 352
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSlIAAAALyLASKTEETP-PWTKELVHYTGYfTEEEILRMER 79


                   ..
gi 584910      353 KM 354
Cdd:smart00385  80 LL 81
 
Name Accession Description Interval E-value
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 141-267 7.39e-77

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 233.58  E-value: 7.39e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   141 CSEYVNDIYLYMRHLEREFKVRTDYMAMQ-EITERMRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQ 219
Cdd:cd20507   1 VSEYVKDIYKYLRQLEKKYAIDPDYLSGQpEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQ 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 584910   220 LVGVTSMLIAA-YEEMYA-EIGDFVYITDNAYSKAQIRAMECNILRKLDF 267
Cdd:cd20507  81 LVGVTALLIASkYEEIYPpEIKDFVYITDNAYTREEILQMERDILKTLDF 130
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 137-267 9.73e-62

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 195.08  E-value: 9.73e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   137 NPQLCSEYVNDIYLYMRHLEREFKVRTDYMAMQEITERMRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKT 216
Cdd:cd20566   1 NPQLCSDYVKDIYQYLRQLEVQQSIRPHYLDGKEINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRK 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 584910   217 KLQLVGVTSMLIAA-YEEMYA-EIGDFVYITDNAYSKAQIRAMECNILRKLDF 267
Cdd:cd20566  81 KLQLVGVTALLLASkYEEMYSpEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 129-267 4.14e-58

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 186.40  E-value: 4.14e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   129 DIDKDDHENPQLCSEYVNDIYLYMRHLEREFKVRTDYMAMQ-EITERMRTILIDWLVQVHLRFHLLQETLFLTIQILDRY 207
Cdd:cd20567   6 DIDEVDKNNPLAAVEYVEDIYSFYRKVEPESCVPPYYMSQQpDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRF 85

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 584910   208 LEGASVSKTKLQLVGVTSMLIAA-YEEMYA-EIGDFVYITDNAYSKAQIRAMECNILRKLDF 267
Cdd:cd20567  86 LSVKQVPRKELQLVGVTAMLIASkYEEIWApEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 141-267 9.57e-55

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 176.99  E-value: 9.57e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   141 CSEYVNDIYLYMRHLEREFKVRTDYMAMQEITERMRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQL 220
Cdd:cd20565   1 CSEYVKDIYAYLRQLEEEQAVRPKYLEGQEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 584910   221 VGVTSMLIAA-YEEMY-AEIGDFVYITDNAYSKAQIRAMECNILRKLDF 267
Cdd:cd20565  81 VGVTAMFIASkYEEMYpPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
97-354 1.40e-50

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 175.73  E-value: 1.40e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910    97 VEKVQSPEPMDMSEVSNALEAFSQNILEMGVDDIDKDDHENPQLCSEYVNDIYLYMRHLEREFKVRTDYMAMQEITE-RM 175
Cdd:COG5024 133 DENSLSPYELDENQLALDEKQAESKRESQSWQDLDATDQEDPLMVPEYASDIFEYLLKLELIDLPNPNYLIKQSLYEwSM 212

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   176 RTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQLVGVTSMLIAA-YEEMYAE-IGDFVYITDNAYSKAQ 253
Cdd:COG5024 213 RSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASkYEEVNCPsIKDLVYATDGAFTRDD 292

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   254 IRAMECNILRKLDFNLGKPLCIHFLRRCSKAGGVDGHKHTLSKYIMELTL*EYSFVKYD*EI--AAAALLSTRFWDEDmE 331
Cdd:COG5024 293 IIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSRTPAKFSSEISPVDYKFIQISPSWcaAAAMYLSRKILSQN-Q 371

                       250       260
                ....*....|....*....|....
gi 584910   332 WTKSLVHYS-AYSEGHLGPIVQKM 354
Cdd:COG5024 372 WDRTLIHYSgNYTNPDLKPLNESN 395
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 147-270 1.51e-49

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 163.46  E-value: 1.51e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910     147 DIYLYMRHLEREFKVRTDYMAMQ-EITERMRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQLVGVTS 225
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQpDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 584910     226 MLIAA-YEEMYA-EIGDFVYITDNAYSKAQIRAMECNILRKLDFNLG 270
Cdd:pfam00134  81 LFIAAkYEEIYPpTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 272-382 1.00e-48

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 160.47  E-value: 1.00e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   272 PLCIHFLRRCSKAGGVDGHKHTLSKYIMELTL*EYSFVKY-D*EIAAAALLSTRFWDEDMEWTKSLVHYSAYSEGHLGPI 350
Cdd:cd20509   1 PLPLHFLRRFSKAGGADAQKHTLAKYLMELTLLDYDMVHYkPSEIAAAALCLSRKILDEPEWTPTLEHYSTYSEEDLLPI 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 584910   351 VQKMAVLSQQSHpsPNSRLDQEEDMASSKFMS 382
Cdd:cd20509  81 VQKMAKLVVKSQ--TSKYQAVKNKYSSSKFMR 110
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 143-267 3.09e-48

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 160.11  E-value: 3.09e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   143 EYVNDIYLYMRHLEREFKVRTDYMAMQ-EITERMRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQLV 221
Cdd:cd20504   1 EYADDIYEYLRESELKHRPKPDYMRKQpDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLV 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 584910   222 GVTSMLIAA-YEEMYA-EIGDFVYITDNAYSKAQIRAMECNILRKLDF 267
Cdd:cd20504  81 GTACMFIAAkYEEIYPpEVEEFVYITDDTYTKKQVLRMEHLVLKVLSF 128
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 129-267 2.47e-47

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 158.19  E-value: 2.47e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   129 DIDKDDHENPQLCSEYVNDIYLYMRHLEREFKVrTDYMAMQ-EITERMRTILIDWLVQVHLRFHLLQETLFLTIQILDRY 207
Cdd:cd20508   1 DIDEENSDDPFQVSEYAKDIFDYMKEREEKFVV-PDYLEKQtELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLY 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 584910   208 LEGASVSKTKLQLVGVTSMLIAA--YEEMYAEIGDFVYITDNAYSKAQIRAMECNILRKLDF 267
Cdd:cd20508  80 LSKKVVKKEKLQLLGATAILIASkfDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDF 141
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 137-267 2.63e-47

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 157.84  E-value: 2.63e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   137 NPQLCSEYVNDIYLYMRHLEREFKVRTDYMAMQ-EITERMRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSK 215
Cdd:cd20568   1 DPLMVAEYVPEIFEYLRELELKTLPNPNYMDDQkELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSL 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 584910   216 TKLQLVGVTSMLIAA-YEEMYA-EIGDFVYITDNAYSKAQIRAMECNILRKLDF 267
Cdd:cd20568  81 NKLQLVGISALFIASkYEEVNSpSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 137-267 2.15e-41

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 142.55  E-value: 2.15e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   137 NPQLCSEYVNDIYLYMRHLEREFKVRTDYM--AMQEITERMRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVS 214
Cdd:cd20562   1 DPQMCSLYATDIYLNLRVAELKRRPLPDYMekIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVN 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 584910   215 KTKLQLVGVTSMLIAA-YEEMYA-EIGDFVYITDNAYSKAQIRAMECNILRKLDF 267
Cdd:cd20562  81 RQRLQLLGVSCMLIASkYEEICApQVEEFCYITDNTYTKQEVLEMEIDVLNALQF 135
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 142-268 2.06e-34

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 124.01  E-value: 2.06e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   142 SEYVNDIYLYMRHLEREFKVRTDYMAMQ-EITERMRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQL 220
Cdd:cd20561   2 PDYHEDIHTYLREMEVKCKPKVGYMKKQpDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQL 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 584910   221 VGVTSMLIAA-YEEMY-AEIGDFVYITDNAYSKAQIRAMECNILRKLDFN 268
Cdd:cd20561  82 VGTAAMLLASkFEEIYpPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFD 131
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 142-268 2.58e-34

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 124.95  E-value: 2.58e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   142 SEYVNDIYLYMRHLEREFKVRTDYMAMQ-EITERMRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQL 220
Cdd:cd20560  34 PEYAEDIHQYLREAELKHRPKPGYMRKQpDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSVLRGKLQL 113

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 584910   221 VGVTSMLIAA-YEEMY-AEIGDFVYITDNAYSKAQIRAMECNILRKLDFN 268
Cdd:cd20560 114 VGTAAILLASkYEEIYpPEVDEFVYITDDTYTKKQLLRMEHLLLKVLAFD 163
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 175-265 2.30e-29

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 109.34  E-value: 2.30e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   175 MRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQLVGVTSMLIAA-YEEMY-AEIGDFVYITDNAYSKA 252
Cdd:cd20536   1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACkQEEIYpPEVKDLLALCCGAYTRE 80

                        90
                ....*....|...
gi 584910   253 QIRAMECNILRKL 265
Cdd:cd20536  81 QICNLECIILTKL 93
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 147-267 1.80e-26

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 102.78  E-value: 1.80e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   147 DIYLYMRHLEREFKVRTDYMAMQ-EITERMRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGAS-VSKTKLQLVGVT 224
Cdd:cd20519   7 EVWDLMLKKEELYKRDRDFLNRHpSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTnVPKTQLQLIGIT 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 584910   225 SMLIAA-YEEMYA-EIGDFVYITDNAYSKAQIRAMECNILRKLDF 267
Cdd:cd20519  87 CLFIAAkLEEIYPpKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 176-269 1.34e-24

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 96.62  E-value: 1.34e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   176 RTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQLVGVTSMLIAA-YEEMYA-EIGDFVYITDNAYSKAQ 253
Cdd:cd20542   1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACkFEERFPpEVATLCYLTDDSYSKKQ 80

                        90
                ....*....|....*.
gi 584910   254 IRAMECNILRKLDFNL 269
Cdd:cd20542  81 VLRMERRVLRRLRFDL 96
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 272-382 4.59e-24

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 95.77  E-value: 4.59e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910     272 PLCIHFLRRCSKAGGV--DGHKHTLSKYIMELTL*EYSFVKYD*-EIAAAALLSTRFWDEDMEWTKSLVHYSAYSEGHLG 348
Cdd:pfam02984   1 PTPLSFLRRFSKAADYlhDLELRTLAKYLLELTLLDYDFLKYPPsLIAAAAVYLARKTLNSPEWTETLEHYTGYSEEDLK 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 584910     349 PIVQKMAVLSQQshpSPNSRLDQ-EEDMASSKFMS 382
Cdd:pfam02984  81 PCVKLLLELLLN---APSSKLQAvRRKYSSSKFMK 112
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
 272-355 2.29e-22

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410273  Cd Length: 119  Bit Score: 91.10  E-value: 2.29e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   272 PLCIHFLRRCSKAGGVDGHKHTLSKYIMELTL*EYSFVKYD-*EIAAAAL-LSTRFWDEDmEWTKSLVHYSAYSEGHLGP 349
Cdd:cd20570   1 PLPLHFLRRASKAGSADVEKHTLAKYLMELTLIDYDMVHYHpSEIAAAALcLSQKVLDGG-KWSLTQQYYTGYTEDDLKP 79


                ....*.
gi 584910   350 IVQKMA 355
Cdd:cd20570  80 IMQHMA 85
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 272-364 5.08e-20

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 84.64  E-value: 5.08e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   272 PLCIHFLRRCSKAGGVDGHKHTLSKYIMELTL*EYSFVKY-D*EIAAAALLSTRFWDEDMEWTKSLVHYSAYSEGHLGPI 350
Cdd:cd20510   1 PLSYRFLRRYAKCARASMETLTLARYILELSLMEYQFVQErASKLAAAALLLALKMKNLGEWTPTLEYYSGYSAEDLLPL 80

                        90
                ....*....|....*
gi 584910   351 VQKM-AVLSQQSHPS 364
Cdd:cd20510  81 VRKLnAMLTKPPNKK 95
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 272-381 1.73e-18

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410272  Cd Length: 121  Bit Score: 80.70  E-value: 1.73e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   272 PLCIHFLRRCSKAGGVDGHKHTLSKYIMELTL*EYSFVKYD-*EIAAAAL-LSTRFWDEDmEWTKSLVHYSAYSEGHLGP 349
Cdd:cd20569   1 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMVDYDMVHFPpSQIAAAAFcLALKILDNG-EWTPTLQHYMSYTEESLLP 79

                        90       100       110
                ....*....|....*....|....*....|..
gi 584910   350 IVQKMAVLSQQSHPSPNSRLDQEEDMASSKFM 381
Cdd:cd20569  80 VMQHMAKNVVKVNQGLTKHMTVKNKYASSKQM 111
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 138-267 1.27e-17

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 78.77  E-value: 1.27e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   138 PQLCSEYVNDIYLYMRHLEREFKVRTDYMAMQEITE-RMRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEG-ASVSK 215
Cdd:cd20579   4 PVLGWANRDEVWKNMLNKDKTYLRDKNFLQKHPLLQpKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATqENVVK 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 584910   216 TKLQLVGVTSMLIAA-YEEMY-AEIGDFVYITDNAYSKAQIRAMECNILRKLDF 267
Cdd:cd20579  84 TRLQLIGISSLFIAAkLEEIYpPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 174-265 3.65e-16

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 74.50  E-value: 3.65e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   174 RMRTILIDWLVQVHLRFHLLQETLFLTIQILDRY-LEGASVSKTKLQLVGVTSMLIAA-YEEMYA-EIGDFVYITDNAYS 250
Cdd:cd20580  41 KMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKNINKSMLQLIGITSLFIASkLEEIYPpKLHEFAYVTDGACS 120

                        90
                ....*....|....*
gi 584910   251 KAQIRAMECNILRKL 265
Cdd:cd20580 121 EDDILDMELIILKAL 135
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 173-257 6.41e-15

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 69.65  E-value: 6.41e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   173 ERMRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQLVGVTSMLIAA--YEEMYAEIGDFVYITDNAYS 250
Cdd:cd20521   1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATrfLGKDILTIREAAWLTDNTYK 80


                ....*..
gi 584910   251 KAQIRAM 257
Cdd:cd20521  81 YEDVVRM 87
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 275-355 1.64e-14

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 69.18  E-value: 1.64e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   275 IHFLRRCSKAGGVDGHKHTLSKYIMELTL*EYSFVKYD*E-IAAAAL-LSTRFWDEDmEWTKSLVHYSAYSEGHLGPIVQ 352
Cdd:cd20512   3 MNFLRRISKADDYDIQTRTLAKYLLEITILDHRFLGYPPSlLAAAAMyLARKMLGRG-DWNDNLVHYSGYTESQLIPCAD 81


                ...
gi 584910   353 KMA 355
Cdd:cd20512  82 IML 84
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 181-263 2.34e-13

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 64.92  E-value: 2.34e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910      181 DWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQLVGVTSMLIAA-YEEMYAEIGDFVYITDNaYSKAQIRAMEC 259
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASkTEETPPWTKELVHYTGY-FTEEEILRMER 79


                   ....
gi 584910      260 NILR 263
Cdd:smart00385  80 LLLE 83
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 277-365 8.81e-12

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 61.50  E-value: 8.81e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   277 FLRRCSK-AGGVDGHKHT--LSKYIMELTL*EYSFVKY-D*EIAAAALLSTRFWDEDMEWTKSLVHYSAYSEGHLGPIVQ 352
Cdd:cd20506   6 FLRRFLRaAQASVPDLKLefLANYLAELSLLDYEFLKYlPSLIAASAVFLARHTLNPHPWNPTLEHYTGYKAADLKPCVQ 85

                        90
                ....*....|...
gi 584910   353 KMAVLSQQSHPSP 365
Cdd:cd20506  86 ALHDLQLNASGSS 98
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 155-268 5.05e-11

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 60.39  E-value: 5.05e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   155 LEREFKVRTDYM--AMQEITERMRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQLVGVTSMLIAA-- 230
Cdd:cd20575  33 LEERYVPRVSYFqcVQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGAVCMLLASkl 112

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 584910   231 YEEMYAEIGDFVYITDNAYSKAQIRAMECNILRKLDFN 268
Cdd:cd20575 113 RETTPLTIEKLCIYTDNSISPRQLLDWEILVLGKLKWD 150
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 170-265 3.24e-10

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 58.08  E-value: 3.24e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   170 EITERMRTILIDWLVQVhLRFHLLQETLF-LTIQILDRYLEGASVSKTKLQLVGVTSMLIA----AYEEMYAEigDFVYI 244
Cdd:cd20515  50 EIQPFMRKMVTTWMLEV-CEEQNCEEEVFpLAVNYLDRFLSLVPIRKSQLQLLGAVCLFLAsklkETIPLTAE--KLCIY 126

                        90       100
                ....*....|....*....|.
gi 584910   245 TDNAYSKAQIRAMECNILRKL 265
Cdd:cd20515 127 TDNSITLQELLDWELLVLTKL 147
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 272-360 9.09e-10

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 55.01  E-value: 9.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   272 PLCIHFLRRCSKAGGVDGHKHTLSKYIMELTL*EYSFVKYD-*EIAAAAL-LSTRFWDEDMEWTKSLVHYSAYSEGHLGP 349
Cdd:cd20537   1 PTPLSFLRRYLSLLGLDEKVRHLARYLLELSLLDYEFLKYRpSLIAAAALyLARKILGEPPPSPQLLQLVTGYSENDLQE 80

                        90
                ....*....|.
gi 584910   350 IVQKMAVLSQQ 360
Cdd:cd20537  81 CAKELLELLAQ 91
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 179-268 1.19e-09

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 55.08  E-value: 1.19e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   179 LIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQLVGVTSMLIAA-YEEMYAE---IGDFVYITDNAYSKAQI 254
Cdd:cd20559   2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASkFWESKARvplLSELSKMCCNSYGEELF 81

                        90
                ....*....|....
gi 584910   255 RAMECNILRKLDFN 268
Cdd:cd20559  82 IQMEMHILNTLNWD 95
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 276-354 1.23e-09

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 54.52  E-value: 1.23e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910      276 HFLRRCSKAGGVDGHKHTLSKYIMELTL*EYSFVKYD*E-IAAAAL-LSTRFWDEDmEWTKSLVHYSAY-SEGHLGPIVQ 352
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSlIAAAALyLASKTEETP-PWTKELVHYTGYfTEEEILRMER 79


                   ..
gi 584910      353 KM 354
Cdd:smart00385  80 LL 81
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 175-267 1.79e-09

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 54.53  E-value: 1.79e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   175 MRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQLVGVTSMLIAA-YEE---MYAEIGDFVYITDN-AY 249
Cdd:cd20528   6 LRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAkFEElddNIPKISDLNRYLCNsVY 85

                        90
                ....*....|....*...
gi 584910   250 SKAQIRAMECNILRKLDF 267
Cdd:cd20528  86 SKQEYLQMELLILEFFQW 103
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 180-269 2.14e-08

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 51.54  E-value: 2.14e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   180 IDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQLVGVTSMLIAAY----EEMYAEIGDFVYITDNAYSKAQIR 255
Cdd:cd20526   6 VRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKtneeDEVIPSTKDLVRVSKCGCSVAEVL 85

                        90
                ....*....|....
gi 584910   256 AMECNILRKLDFNL 269
Cdd:cd20526  86 RMERIILDKLHWDL 99
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 179-258 4.18e-08

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 50.10  E-value: 4.18e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   179 LIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQLVGVTSMLIAA-YEEMYAEIGDFVYITDnaYSKAQIRAM 257
Cdd:cd00043   2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACkLEELPRTLKEIAKVSG--VSEKELRKA 79


                .
gi 584910   258 E 258
Cdd:cd00043  80 E 80
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 169-268 3.02e-07

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 49.59  E-value: 3.02e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   169 QEITERMRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQLVGVTSMLIAA--YEEMYAEIGDFVYITD 246
Cdd:cd20573  48 KEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATCMFLASkmKETIPLTAEKLCIYTD 127

                        90       100
                ....*....|....*....|..
gi 584910   247 NAYSKAQIRAMECNILRKLDFN 268
Cdd:cd20573 128 NSIRPEELLQMELLVLNKLKWD 149
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 277-363 1.03e-05

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 44.21  E-value: 1.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   277 FLRRCSKAGGVDGHKHTLSKYIMELTL*EYS-FVKY-D*EIAAAALLSTRFWDEDMEWTKSLVHYSAYSEGHLGPIVQKM 354
Cdd:cd20505   6 FLERFLKHSNADEKTKSLAMYLCELSLIDADpYLKYlPSVIAAAAVCLANHTLGNEVWPQKLARSTGYSLEDLLPCLRDL 85

                        90
                ....*....|.
gi 584910   355 --AVLSQQSHP 363
Cdd:cd20505  86 hrTFLNAPSSP 96
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 276-357 1.04e-05

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 44.22  E-value: 1.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   276 HFLRRCSKAGGVDGHKHTLSKYIMELTL*EYSFVKYD*EIAAAALLST--RFWDEDMEWTKSLVHYSAYSEGHLGPIVQK 353
Cdd:cd20511   5 VFLVRFLKAAQSDKKLENLAFFLVELGLVEYEMLKYSPSMLAASAVYTarCTLNKTPEWTSTLEFHTGYSESQLMECARL 84


                ....
gi 584910   354 MAVL 357
Cdd:cd20511  85 MVRL 88
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 169-268 1.53e-04

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 41.90  E-value: 1.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   169 QEITERMRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQLVGVTSMLIAA-YEEMYAEIGDFVYI-TD 246
Cdd:cd20574  49 KDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTRKCHLQLLGAVCMFLASkLKETIPLTAEKLCIyTD 128

                        90       100
                ....*....|....*....|..
gi 584910   247 NAYSKAQIRAMECNILRKLDFN 268
Cdd:cd20574 129 NSIKPQELLEWELVVLGKLKWN 150
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 171-265 1.60e-04

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 40.62  E-value: 1.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   171 ITERMRTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTKLQLVGVTSMLIAAYEEMYAEI--GDFVYITDNA 248
Cdd:cd20517   1 VTSDNRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVKPItvSKLTYLSCDC 80

                        90
                ....*....|....*..
gi 584910   249 YSKAQIRAMECNILRKL 265
Cdd:cd20517  81 FTNLELINQEKDILEAL 97
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 176-266 2.54e-04

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 39.99  E-value: 2.54e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   176 RTILIDWLVQVHLRFHLLQETLFLTIQILDRYLEGASVSKTK---LQLVGVTSMLIAA--YEEMYAEIGDF-VYITDNAY 249
Cdd:cd20543   2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKpwmLQLLAVACLSLAAkmEETDVPLLVDLqVEEPKYVF 81

                        90
                ....*....|....*..
gi 584910   250 SKAQIRAMECNILRKLD 266
Cdd:cd20543  82 EAKTIQRMELLVLSTLE 98
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 291-354 5.43e-04

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 38.88  E-value: 5.43e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584910   291 KHTLSKYI---MELTL*EYSFVKYD*E-IAAAALLSTRFwDEDME--WTKSLVHYSAYSEGHLGPIVQKM 354
Cdd:cd20529  33 KEYVRKYAdffLDLSLQDYAFLNYKPSlLAAACIAAARK-ALGLSptWPEELEKLTGYSEDELEPCVELL 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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