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Conserved domains on  [gi|51338763|sp|P20823|]
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RecName: Full=Hepatocyte nuclear factor 1-alpha; Short=HNF-1-alpha; Short=HNF-1A; AltName: Full=Liver-specific transcription factor LF-B1; Short=LFB1; AltName: Full=Transcription factor 1; Short=TCF-1

Protein Classification

HNF-1_N and HNF-1B_C domain-containing protein( domain architecture ID 11153346)

protein containing domains HNF-1_N, homeodomain, HNF-1B_C, and HNF-1A_C

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HNF-1B_C pfam04812
Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region ...
 282-540 7.52e-110

Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region found within the alpha isoform and at the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


:

Pssm-ID: 461438  Cd Length: 258  Bit Score: 330.81  E-value: 7.52e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338763   282 AMDTYSGPPPGPGPGpALPAHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGG---PLVTVSTPLHQVSPTGLEP 358
Cdd:pfam04812   1 AMDAYSGPQPHSANP-LLPHSSPHHPQPSASPPSKVQGVRYSQQGPSEVTSSSTISHHgnsAMVTSQSVLQQVSPVGLEP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338763   359 SHSLLSTEAKLVSAAGGPLPPVSTLTALHSLeqTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGL 438
Cdd:pfam04812  80 SHSLLSTDAKMISVSGGGLPPVSTLTNLHSL--NSHHSPQQTQNLIMASLPGVMAIGPGETLSLEPNFTNTGGSQLVIGL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338763   439 ASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVTQSPFMATMAQLQSPHaLYSHKPEVAQYTHTGLL 518
Cdd:pfam04812 158 NSSQAQSVPVINSVGSSLATLQPVQFSQQLHSSHQQPLMQQSQSHMAQSPFMATMAQLQNSH-MYSHKQEPPQYSHTSLF 236

                         250       260
                  ....*....|....*....|..
gi 51338763   519 PQTMLITDTTNLSALASLTPTK 540
Cdd:pfam04812 237 PSAMVITDTSSLSTLTSLTSTK 258
HNF-1_N pfam04814
Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of ...
 8-168 3.56e-66

Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


:

Pssm-ID: 461440  Cd Length: 178  Bit Score: 214.30  E-value: 3.56e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338763     8 LQTELLAALLESGLSKEALIQALGEPGPY-----LLAGEGPLDKGESCGGgRGELAELPNGLGETRGSEDETDDDGED-- 80
Cdd:pfam04814   1 EQIELLQRLLRSGLTKEELIHALEELEPLdpefgVKLESLPLSPGSSCDS-KPVFPTLANGHGPSSSSSSSSTSKLSGde 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338763    81 --------FTPPIL---KELENLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLN 149
Cdd:pfam04814  80 gssdgnsyDTPPILdlgGELGDLDPEEAAEQRAEVEELLREDPWRVAEMIKGYLQQHNIPQREVVDVTGLNQSHLSQHLN 159

                         170
                  ....*....|....*....
gi 51338763   150 KGTPMKTQKRAALYTWYVR 168
Cdd:pfam04814 160 KGTPMKTQKRAALYTWYVR 178
HNF-1A_C pfam04813
Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus; This family consists of an ...
 542-630 3.10e-26

Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus; This family consists of an alternative C terminus of homeobox-containing transcription factor HNF-1, found in the HNF-1A isoform. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription, and HNF-1A, which has this C-terminal extension, transactivates less well than the B and C isoforms. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


:

Pssm-ID: 461439  Cd Length: 85  Bit Score: 102.54  E-value: 3.10e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338763   542 VFTSDTEASSESGLHTPASQATTLHVPSQDPAgiqhLQPAHRLSASPTVSSSSLVLYQSSDSSNGQSHLLPSNHSVIETF 621
Cdd:pfam04813   1 VFTSDPETQSESGLHTPVSQADTIHIPNQDPA----QQPGHRLSASPAVSSSSLVLYQSSDSTNSHSHLLSSNHTVIETF 76


                  ....*....
gi 51338763   622 ISTQMASSS 630
Cdd:pfam04813  77 ISTQMASSS 85
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 200-273 2.65e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 50.70  E-value: 2.65e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 51338763 200 RRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNraeciqrgvspsqaqglgsnlVTEVRVYNWFANRRK 273
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELG---------------------LTERQVKIWFQNRRA 53
 
Name Accession Description Interval E-value
HNF-1B_C pfam04812
Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region ...
 282-540 7.52e-110

Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region found within the alpha isoform and at the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 461438  Cd Length: 258  Bit Score: 330.81  E-value: 7.52e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338763   282 AMDTYSGPPPGPGPGpALPAHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGG---PLVTVSTPLHQVSPTGLEP 358
Cdd:pfam04812   1 AMDAYSGPQPHSANP-LLPHSSPHHPQPSASPPSKVQGVRYSQQGPSEVTSSSTISHHgnsAMVTSQSVLQQVSPVGLEP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338763   359 SHSLLSTEAKLVSAAGGPLPPVSTLTALHSLeqTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGL 438
Cdd:pfam04812  80 SHSLLSTDAKMISVSGGGLPPVSTLTNLHSL--NSHHSPQQTQNLIMASLPGVMAIGPGETLSLEPNFTNTGGSQLVIGL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338763   439 ASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVTQSPFMATMAQLQSPHaLYSHKPEVAQYTHTGLL 518
Cdd:pfam04812 158 NSSQAQSVPVINSVGSSLATLQPVQFSQQLHSSHQQPLMQQSQSHMAQSPFMATMAQLQNSH-MYSHKQEPPQYSHTSLF 236

                         250       260
                  ....*....|....*....|..
gi 51338763   519 PQTMLITDTTNLSALASLTPTK 540
Cdd:pfam04812 237 PSAMVITDTSSLSTLTSLTSTK 258
HNF-1_N pfam04814
Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of ...
 8-168 3.56e-66

Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 461440  Cd Length: 178  Bit Score: 214.30  E-value: 3.56e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338763     8 LQTELLAALLESGLSKEALIQALGEPGPY-----LLAGEGPLDKGESCGGgRGELAELPNGLGETRGSEDETDDDGED-- 80
Cdd:pfam04814   1 EQIELLQRLLRSGLTKEELIHALEELEPLdpefgVKLESLPLSPGSSCDS-KPVFPTLANGHGPSSSSSSSSTSKLSGde 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338763    81 --------FTPPIL---KELENLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLN 149
Cdd:pfam04814  80 gssdgnsyDTPPILdlgGELGDLDPEEAAEQRAEVEELLREDPWRVAEMIKGYLQQHNIPQREVVDVTGLNQSHLSQHLN 159

                         170
                  ....*....|....*....
gi 51338763   150 KGTPMKTQKRAALYTWYVR 168
Cdd:pfam04814 160 KGTPMKTQKRAALYTWYVR 178
HNF-1A_C pfam04813
Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus; This family consists of an ...
 542-630 3.10e-26

Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus; This family consists of an alternative C terminus of homeobox-containing transcription factor HNF-1, found in the HNF-1A isoform. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription, and HNF-1A, which has this C-terminal extension, transactivates less well than the B and C isoforms. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 461439  Cd Length: 85  Bit Score: 102.54  E-value: 3.10e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338763   542 VFTSDTEASSESGLHTPASQATTLHVPSQDPAgiqhLQPAHRLSASPTVSSSSLVLYQSSDSSNGQSHLLPSNHSVIETF 621
Cdd:pfam04813   1 VFTSDPETQSESGLHTPVSQADTIHIPNQDPA----QQPGHRLSASPAVSSSSLVLYQSSDSTNSHSHLLSSNHTVIETF 76


                  ....*....
gi 51338763   622 ISTQMASSS 630
Cdd:pfam04813  77 ISTQMASSS 85
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 200-273 2.65e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 50.70  E-value: 2.65e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 51338763 200 RRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNraeciqrgvspsqaqglgsnlVTEVRVYNWFANRRK 273
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELG---------------------LTERQVKIWFQNRRA 53
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 199-273 2.56e-07

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 47.63  E-value: 2.56e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 51338763    199 GRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNraeciqrgvspsqaqglgsnlVTEVRVYNWFANRRK 273
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLG---------------------LSERQVKVWFQNRRA 54
Homeodomain pfam00046
Homeodomain;
200-272 1.70e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 39.79  E-value: 1.70e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 51338763   200 RRNRfkWGPASQQI--LFQAYERQKNPSKEERETLVEECNraeciqrgvspsqaqglgsnlVTEVRVYNWFANRR 272
Cdd:pfam00046   1 RRKR--TTFTPEQLeeLEKEFQENPYPSAEEREELAAQLG---------------------LTERQVKVWFQNRR 52
 
Name Accession Description Interval E-value
HNF-1B_C pfam04812
Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region ...
 282-540 7.52e-110

Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region found within the alpha isoform and at the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 461438  Cd Length: 258  Bit Score: 330.81  E-value: 7.52e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338763   282 AMDTYSGPPPGPGPGpALPAHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGG---PLVTVSTPLHQVSPTGLEP 358
Cdd:pfam04812   1 AMDAYSGPQPHSANP-LLPHSSPHHPQPSASPPSKVQGVRYSQQGPSEVTSSSTISHHgnsAMVTSQSVLQQVSPVGLEP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338763   359 SHSLLSTEAKLVSAAGGPLPPVSTLTALHSLeqTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGL 438
Cdd:pfam04812  80 SHSLLSTDAKMISVSGGGLPPVSTLTNLHSL--NSHHSPQQTQNLIMASLPGVMAIGPGETLSLEPNFTNTGGSQLVIGL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338763   439 ASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVTQSPFMATMAQLQSPHaLYSHKPEVAQYTHTGLL 518
Cdd:pfam04812 158 NSSQAQSVPVINSVGSSLATLQPVQFSQQLHSSHQQPLMQQSQSHMAQSPFMATMAQLQNSH-MYSHKQEPPQYSHTSLF 236

                         250       260
                  ....*....|....*....|..
gi 51338763   519 PQTMLITDTTNLSALASLTPTK 540
Cdd:pfam04812 237 PSAMVITDTSSLSTLTSLTSTK 258
HNF-1_N pfam04814
Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of ...
 8-168 3.56e-66

Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 461440  Cd Length: 178  Bit Score: 214.30  E-value: 3.56e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338763     8 LQTELLAALLESGLSKEALIQALGEPGPY-----LLAGEGPLDKGESCGGgRGELAELPNGLGETRGSEDETDDDGED-- 80
Cdd:pfam04814   1 EQIELLQRLLRSGLTKEELIHALEELEPLdpefgVKLESLPLSPGSSCDS-KPVFPTLANGHGPSSSSSSSSTSKLSGde 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338763    81 --------FTPPIL---KELENLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLN 149
Cdd:pfam04814  80 gssdgnsyDTPPILdlgGELGDLDPEEAAEQRAEVEELLREDPWRVAEMIKGYLQQHNIPQREVVDVTGLNQSHLSQHLN 159

                         170
                  ....*....|....*....
gi 51338763   150 KGTPMKTQKRAALYTWYVR 168
Cdd:pfam04814 160 KGTPMKTQKRAALYTWYVR 178
HNF-1A_C pfam04813
Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus; This family consists of an ...
 542-630 3.10e-26

Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus; This family consists of an alternative C terminus of homeobox-containing transcription factor HNF-1, found in the HNF-1A isoform. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription, and HNF-1A, which has this C-terminal extension, transactivates less well than the B and C isoforms. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 461439  Cd Length: 85  Bit Score: 102.54  E-value: 3.10e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51338763   542 VFTSDTEASSESGLHTPASQATTLHVPSQDPAgiqhLQPAHRLSASPTVSSSSLVLYQSSDSSNGQSHLLPSNHSVIETF 621
Cdd:pfam04813   1 VFTSDPETQSESGLHTPVSQADTIHIPNQDPA----QQPGHRLSASPAVSSSSLVLYQSSDSTNSHSHLLSSNHTVIETF 76


                  ....*....
gi 51338763   622 ISTQMASSS 630
Cdd:pfam04813  77 ISTQMASSS 85
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 200-273 2.65e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 50.70  E-value: 2.65e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 51338763 200 RRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNraeciqrgvspsqaqglgsnlVTEVRVYNWFANRRK 273
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELG---------------------LTERQVKIWFQNRRA 53
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 199-273 2.56e-07

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 47.63  E-value: 2.56e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 51338763    199 GRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNraeciqrgvspsqaqglgsnlVTEVRVYNWFANRRK 273
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLG---------------------LSERQVKVWFQNRRA 54
Homeodomain pfam00046
Homeodomain;
200-272 1.70e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 39.79  E-value: 1.70e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 51338763   200 RRNRfkWGPASQQI--LFQAYERQKNPSKEERETLVEECNraeciqrgvspsqaqglgsnlVTEVRVYNWFANRR 272
Cdd:pfam00046   1 RRKR--TTFTPEQLeeLEKEFQENPYPSAEEREELAAQLG---------------------LTERQVKVWFQNRR 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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