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Conserved domains on  [gi|71153495|sp|P23645|]
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RecName: Full=Neurogenic protein big brain

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 58-273 2.59e-93

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 288.45  E-value: 2.59e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495    58 EIRTLEFWRSIISECLASFMYVFIVCGAAAG--VGVGASVSSVLLATALASGLAMATLTQCFLHISGAHINPAVTLALCV 135
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGvkKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495   136 VRSISPIRAAMYITAQCGGGIAGAALLYGVTvPGYQGNLQAAISHSAALAAWERFGVEFILTFLVVLCYFVSTDPMKKFM 215
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVT-VGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGS 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71153495   216 GNSAA--SIGCAYSACCFVSMPY----LNPARSLGPSFVLNKWDSHWVYWFGPLVGGMASGLVY 273
Cdd:pfam00230 160 LGTVAplAIGFAVFLNHLAGGPYtgasMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 58-273 2.59e-93

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 288.45  E-value: 2.59e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495    58 EIRTLEFWRSIISECLASFMYVFIVCGAAAG--VGVGASVSSVLLATALASGLAMATLTQCFLHISGAHINPAVTLALCV 135
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGvkKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495   136 VRSISPIRAAMYITAQCGGGIAGAALLYGVTvPGYQGNLQAAISHSAALAAWERFGVEFILTFLVVLCYFVSTDPMKKFM 215
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVT-VGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGS 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71153495   216 GNSAA--SIGCAYSACCFVSMPY----LNPARSLGPSFVLNKWDSHWVYWFGPLVGGMASGLVY 273
Cdd:pfam00230 160 LGTVAplAIGFAVFLNHLAGGPYtgasMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 70-273 1.38e-79

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 252.60  E-value: 1.38e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495    70 SECLASFMYVFIVC----GAAAGVGVGASVSSVLLATALASGLAMATLTQCFLHISGAHINPAVTLALCVVRSISPIRAA 145
Cdd:TIGR00861   1 AEFLGTFLLVFFGVgsalGVNVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495   146 MYITAQCGGGIAGAALLYGVTVPGYQGNLQAAISHSAALAAWERFGVEFILTFLVVLCYFVSTDPMKKF--MGNSAASIG 223
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVprGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 71153495   224 CAYSACCFVSMPY----LNPARSLGPSFVLNK--WDSHWVYWFGPLVGGMASGLVY 273
Cdd:TIGR00861 161 LLVFLIHLSMGPYtgtgMNPARSLGPALFAGLagWGNHWVYWVGPIIGAILGALVY 216
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 66-276 1.13e-77

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 247.94  E-value: 1.13e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495  66 RSIISECLASFMYVFIVCGAAAGVGVGASVSSVLLATALASGLAMATLTQCFLHISGAHINPAVTLALCVVRSISPIRAA 145
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495 146 MYITAQCGGGIAGAALLYGVTVPGYQGNLQAAI--------SHSAALAAWERFGVEFILTFLVVLCYFVSTDPMKKF--M 215
Cdd:cd00333  81 PYIIAQLLGAILGAALLYGLYYGLYLEFLGANNivagifgtYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPppG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71153495 216 GNSAASIGCAYSACCFVSMPY----LNPARSLGPSFVLN---KWDSHWVYWFGPLVGGMASGLVYEYI 276
Cdd:cd00333 161 GLAPLAIGLLVAAIGLAGGPItgasMNPARSLGPALFTGlarHWHYFWVYWVGPLIGAIAGALVYDYV 228
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 64-277 1.94e-39

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 145.27  E-value: 1.94e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495  64 FWRSIISECLASFMYVFIVCGAAAGVGVGASVSSvLLATALASGLAMATLTQCFLHISGAHINPAVTLALCVVRSISPIR 143
Cdd:COG0580   2 LMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIG-WLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495 144 AAMYITAQCGGGIAGAALLYGV-------------------TVPGYQGNLQAAishsaalaawerFGVEFILTFLVVLCY 204
Cdd:COG0580  81 VLPYIIAQLLGAFLGAALVYLIygghfdatedggaklgvfaTSPAIGYSLGAA------------FLTEIIGTFVLVFVI 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495 205 FVSTDPMKKFMGNSAASIGCAYSACCFVSMP----YLNPARSLGPSFV--LNK----WDSHWVYWFGPLVGGMASGLVYE 274
Cdd:COG0580 149 LGITDKRAAPGGLAPLAIGLLVAAIGLSLGPltgyAINPARDLGPRLFhaLGKggsdWGYLWVPIVAPILGAALAALLYR 228


                ...
gi 71153495 275 YIF 277
Cdd:COG0580 229 ALF 231
PLN00166 PLN00166
aquaporin TIP2; Provisional
 66-277 2.27e-27

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 111.57  E-value: 2.27e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495   66 RSIISECLASFMYVFI----VCGAAAGVGVGASVSSVLLATALASGLAMATLTQCFLHISGAHINPAVTLALCVVRSISP 141
Cdd:PLN00166  19 KAYLSEFIATLLFVFAgvgsAIAFAKLTSDAALDPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495  142 IRAAMYITAQCGGGIAGAALLYGVTvpgyqgNLQAAISH--SAALAAWERFGVEFILTF-LVVLCYFVSTDPMKKFMGNS 218
Cdd:PLN00166  99 ITGFFYWIAQCLGSIVACLLLVFVT------NGESVPTHgvAAGLGAIEGVVMEIVVTFaLVYTVYATAADPKKGSLGTI 172

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71153495  219 AA-SIGCAYSACCFVSMPY----LNPARSLGPSFVLNKWDSHWVYWFGPLVGGMASGLVYEYIF 277
Cdd:PLN00166 173 APiAIGFIVGANILAAGPFsggsMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVF 236
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 58-273 2.59e-93

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 288.45  E-value: 2.59e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495    58 EIRTLEFWRSIISECLASFMYVFIVCGAAAG--VGVGASVSSVLLATALASGLAMATLTQCFLHISGAHINPAVTLALCV 135
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGvkKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495   136 VRSISPIRAAMYITAQCGGGIAGAALLYGVTvPGYQGNLQAAISHSAALAAWERFGVEFILTFLVVLCYFVSTDPMKKFM 215
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVT-VGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGS 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71153495   216 GNSAA--SIGCAYSACCFVSMPY----LNPARSLGPSFVLNKWDSHWVYWFGPLVGGMASGLVY 273
Cdd:pfam00230 160 LGTVAplAIGFAVFLNHLAGGPYtgasMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 70-273 1.38e-79

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 252.60  E-value: 1.38e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495    70 SECLASFMYVFIVC----GAAAGVGVGASVSSVLLATALASGLAMATLTQCFLHISGAHINPAVTLALCVVRSISPIRAA 145
Cdd:TIGR00861   1 AEFLGTFLLVFFGVgsalGVNVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495   146 MYITAQCGGGIAGAALLYGVTVPGYQGNLQAAISHSAALAAWERFGVEFILTFLVVLCYFVSTDPMKKF--MGNSAASIG 223
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVprGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 71153495   224 CAYSACCFVSMPY----LNPARSLGPSFVLNK--WDSHWVYWFGPLVGGMASGLVY 273
Cdd:TIGR00861 161 LLVFLIHLSMGPYtgtgMNPARSLGPALFAGLagWGNHWVYWVGPIIGAILGALVY 216
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 66-276 1.13e-77

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 247.94  E-value: 1.13e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495  66 RSIISECLASFMYVFIVCGAAAGVGVGASVSSVLLATALASGLAMATLTQCFLHISGAHINPAVTLALCVVRSISPIRAA 145
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495 146 MYITAQCGGGIAGAALLYGVTVPGYQGNLQAAI--------SHSAALAAWERFGVEFILTFLVVLCYFVSTDPMKKF--M 215
Cdd:cd00333  81 PYIIAQLLGAILGAALLYGLYYGLYLEFLGANNivagifgtYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPppG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71153495 216 GNSAASIGCAYSACCFVSMPY----LNPARSLGPSFVLN---KWDSHWVYWFGPLVGGMASGLVYEYI 276
Cdd:cd00333 161 GLAPLAIGLLVAAIGLAGGPItgasMNPARSLGPALFTGlarHWHYFWVYWVGPLIGAIAGALVYDYV 228
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 64-277 1.94e-39

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 145.27  E-value: 1.94e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495  64 FWRSIISECLASFMYVFIVCGAAAGVGVGASVSSvLLATALASGLAMATLTQCFLHISGAHINPAVTLALCVVRSISPIR 143
Cdd:COG0580   2 LMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIG-WLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495 144 AAMYITAQCGGGIAGAALLYGV-------------------TVPGYQGNLQAAishsaalaawerFGVEFILTFLVVLCY 204
Cdd:COG0580  81 VLPYIIAQLLGAFLGAALVYLIygghfdatedggaklgvfaTSPAIGYSLGAA------------FLTEIIGTFVLVFVI 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495 205 FVSTDPMKKFMGNSAASIGCAYSACCFVSMP----YLNPARSLGPSFV--LNK----WDSHWVYWFGPLVGGMASGLVYE 274
Cdd:COG0580 149 LGITDKRAAPGGLAPLAIGLLVAAIGLSLGPltgyAINPARDLGPRLFhaLGKggsdWGYLWVPIVAPILGAALAALLYR 228


                ...
gi 71153495 275 YIF 277
Cdd:COG0580 229 ALF 231
PLN00166 PLN00166
aquaporin TIP2; Provisional
 66-277 2.27e-27

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 111.57  E-value: 2.27e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495   66 RSIISECLASFMYVFI----VCGAAAGVGVGASVSSVLLATALASGLAMATLTQCFLHISGAHINPAVTLALCVVRSISP 141
Cdd:PLN00166  19 KAYLSEFIATLLFVFAgvgsAIAFAKLTSDAALDPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495  142 IRAAMYITAQCGGGIAGAALLYGVTvpgyqgNLQAAISH--SAALAAWERFGVEFILTF-LVVLCYFVSTDPMKKFMGNS 218
Cdd:PLN00166  99 ITGFFYWIAQCLGSIVACLLLVFVT------NGESVPTHgvAAGLGAIEGVVMEIVVTFaLVYTVYATAADPKKGSLGTI 172

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71153495  219 AA-SIGCAYSACCFVSMPY----LNPARSLGPSFVLNKWDSHWVYWFGPLVGGMASGLVYEYIF 277
Cdd:PLN00166 173 APiAIGFIVGANILAAGPFsggsMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVF 236
PLN00027 PLN00027
aquaporin TIP; Provisional
 99-277 5.80e-27

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 110.26  E-value: 5.80e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495   99 LLATALASGLAMATLTQCFLHISGAHINPAVTLALCVVRSISPIRAAMYITAQCGGGIAGAALLYGVTvpgyQGNLQAAI 178
Cdd:PLN00027  58 LVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNITLLRGILYWIAQLLGSVVACLLLKFST----GGLETSAF 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495  179 SHSAALAAWERFGVEFILTF-LVVLCYFVSTDPMKKFMGNSAA-SIGCAYSACCFVSMPY----LNPARSLGPSFVLNKW 252
Cdd:PLN00027 134 SLSSGVGVWNAFVFEIVMTFgLVYTVYATAVDPKKGDLGIIAPiAIGFIVGANILAGGAFdgasMNPAVSFGPAVVSWTW 213

                        170       180
                 ....*....|....*....|....*
gi 71153495  253 DSHWVYWFGPLVGGMASGLVYEYIF 277
Cdd:PLN00027 214 TNHWVYWAGPLIGGGIAGLVYELIF 238
PRK05420 PRK05420
aquaporin Z; Provisional
 66-280 1.05e-22

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 97.35  E-value: 1.05e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495   66 RSIISECLASFMYVFIVCGAAAGVGVGASVSSVLLATALASGLAMATLTQCFLHISGAHINPAVTLALCVVRSISPIRAA 145
Cdd:PRK05420   3 KKLAAEFFGTFWLVFGGCGSAVLAAAFPELGIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKELV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495  146 MYITAQCGGGIAGAALLY---------GVTVPGYQGNLQAAIS--HSAALAAwerFGVEFILTFLVVLCYFVSTDPmKKF 214
Cdd:PRK05420  83 PYIIAQVVGGIAAAAVLYliasgkagfDLAGSGFASNGYGEHSpgGYSLLAA---LVCEVVLTAFFLLVILGATDK-RAP 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71153495  215 MGNSAASIGCAYSACCFVSMPY----LNPARSLGPSFVLNKW--DSHWVYWFGPLVGGMASGLVYEYIFNSR 280
Cdd:PRK05420 159 AGFAPIAIGLALTLIHLISIPVtntsVNPARSTGVALFVGGWalEQLWLFWVAPIVGAIIGGLIYRLLLEKD 230
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 66-276 2.22e-20

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 91.84  E-value: 2.22e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495   66 RSIISECLASFMYVFIVCGAAAGVGVGASVSSvLLATALASGLAMATLTQCFLHISGAHINPAVTLALCVVRSISPIRAA 145
Cdd:PLN00183  46 RMVLAEMVGTFILMFCVCGIIASTQLSGGEVG-LLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVP 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495  146 MYITAQCGGGIagAALLYGVTVPGYQGNLQAAishSAALAAWERFGVEFILTFLVVL------CYFVSTDPMKKFMGNSA 219
Cdd:PLN00183 125 LYITAQTVGSV--LATYVGVSVYGVKADLMTT---KPAQGCSSAFWVEFIATFIVMFlaasltSQPQSLGHLSGFVIGIA 199

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 71153495  220 ASIGCAYSACcfVSMPYLNPARSLGPSFVLNKWDSHWVYWFGPLVGGMASGLVYEYI 276
Cdd:PLN00183 200 IGLAVLITGP--VSGGSMNPARSLGPAIVSWDFKDIWIYITAPTIGAVAGALMFHLL 254
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 107-276 5.15e-18

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 84.96  E-value: 5.15e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495  107 GLAMATLTQCFLHISGAHINPAVTLALCVVRSISPIRAAMYITAQCGGGIAGA---ALLYGVTVPGYQGNLQAAISHSAA 183
Cdd:PLN00182  83 GLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVPLYIGAQLTGSLLASltlRLMFNVTPEAFFGTTPTDSSGQAL 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495  184 LAawerfgvEFILTFLVVLCYF-VSTDpmKKFMGNSAA-SIGCAYSACCFVSMPY----LNPARSLGPSFVLNKWDSHWV 257
Cdd:PLN00182 163 VA-------EIIISFLLMFVISgVATD--SRAVGELAGiAVGMTIILNVFVAGPIsgasMNPARSLGPAIVMGRYKGIWV 233

                        170
                 ....*....|....*....
gi 71153495  258 YWFGPLVGGMASGLVYEYI 276
Cdd:PLN00182 234 YIVGPFVGIIAGGFVYNLI 252
PLN00184 PLN00184
aquaporin NIP1; Provisional
 61-276 2.02e-17

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 83.53  E-value: 2.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495   61 TLEFWRSIISECLASFMYVFIVCGAAAGVGVGASVSSvLLATALASGLAMATLTQCFLHISGAHINPAVTLALCVVRSIS 140
Cdd:PLN00184  50 SVPFLQKLIAEVLGTYFLVFTGCASVVVNMQNDNVVT-LPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFP 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495  141 PIRAAMYITAQCGGGIAGAA---LLYGVTVPGYQGNLQAAISHSAALAAWERFGVEFILTF-LVVLCYFVSTDpmKKFMG 216
Cdd:PLN00184 129 LKQVPAYVISQVIGSTLAAAtlrLLFGLDHDVCSGKHDVFIGSSPVGSDLQAFVMEFIVTFyLMFIISGVATD--NRAIG 206

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71153495  217 NSAA-SIGCAYSACCFVSMPY----LNPARSLGPSFVLNKWDSHWVYWFGPLVGGMASGLVYEYI 276
Cdd:PLN00184 207 ELAGlAIGSTVLLNVLIAAPVssasMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVYNTV 271
PLN00167 PLN00167
aquaporin TIP5; Provisional
 66-274 1.52e-16

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 79.95  E-value: 1.52e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495   66 RSIISECLASFMYVFIVCGAAAGV----GVGASVSSVLLATALASGLAMATLTQCFLHISGAHINPAVTLALCVVRSISP 141
Cdd:PLN00167  23 RSYLAEFISTFFFVFAAVGSAMSSrklmPDAASDPSSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGGHISV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495  142 IRAAMYITAQCGGGIAgAALLYGVTVPGyqgnlQAAISHSAAlAAWERFG---VEFILTFLVVLCYFVSTDPMKKFMGNS 218
Cdd:PLN00167 103 PTAMFYWISQMLASVM-ACLFLKVTTVG-----QHVPTYKIA-EEMTGFGasvLEGVLTFGLVYTVYAAGDPRRGLLGAI 175

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71153495  219 AA-SIGCAYSACCFVSMPY----LNPARSLGPSFVLNKWDSHWVYWFGPLVGGMASGLVYE 274
Cdd:PLN00167 176 GPlAIGLVAGANVLAAGPFsggsMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYD 236
PLN00026 PLN00026
aquaporin NIP; Provisional
 99-273 1.23e-15

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 77.98  E-value: 1.23e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495   99 LLATALASGLAMATLTQCFLHISGAHINPAVTLALCVVRSISPIRAAMYITAQCGGGIAGAALLYGVTVPGYQGNLQA-A 177
Cdd:PLN00026 104 LIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPWKHVPAYIAAQVSASICASFALKGVFHPFMSGGVTVpS 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495  178 ISHSAAlaawerFGVEFILTF-LVVLCYFVSTDpmKKFMGNSAA-SIGCAYSACCFVSMPY----LNPARSLGPSFVLNK 251
Cdd:PLN00026 184 VSTGQA------FALEFIITFnLLFVVTAVATD--TRAVGELAGiAVGATVMLNILVAGPStggsMNPVRTLGPAVAAGN 255

                        170       180
                 ....*....|....*....|..
gi 71153495  252 WDSHWVYWFGPLVGGMASGLVY 273
Cdd:PLN00026 256 YRAIWIYLVAPTLGALAGAGTY 277
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 65-276 3.05e-13

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 70.92  E-value: 3.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495   65 WRSIISECLASFMYVFIVCGAAAGVGVGASVSSVL-LATALASGLAMATLTQcfLHISGAHINPAVTLALCVVRSISPIR 143
Cdd:PTZ00016  50 VREYVAEFLGTFVLLFFGEGVVATTHTVGNNGDYLaITIGWGLGVTFGLLVS--AGISGGHLNPAVTLGNAVFGKFPWKK 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495  144 AAMYITAQCGGGIAGAALLYGVtvpgYQGNLQAaisHSAALAAWERF-----GV---------------EFILTFLVVLC 203
Cdd:PTZ00016 128 LPGYFVAQLLGAFVGAACVYGL----YYGFFKD---HGIPELPWETMangfaGVfatypregnfyaifsELILTAILLLV 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71153495  204 YFVSTDP-MKKFMGNSAASIGcaysACCFV-------SMPY-LNPARSLGPS-FVLNKWDSH---------WVYWFGPLV 264
Cdd:PTZ00016 201 ILAITDPnNCPAFNYLPVAVG----LLVFVigisfggNTGYaLNPARDLGPRlFSAILWGSEvftkdnyyfWVPLVAPFV 276

                        250
                 ....*....|..
gi 71153495  265 GGMASGLVYEYI 276
Cdd:PTZ00016 277 GAVLGMFLYDKF 288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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