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Conserved domains on  [gi|543800|sp|P35858|]
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RecName: Full=Insulin-like growth factor-binding protein complex acid labile subunit; Short=ALS; Flags: Precursor

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 20807514)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-536 9.40e-22

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.08  E-value: 9.40e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    94 FQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDglFEGLGSLW 173
Cdd:COG4886  22 TTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD--LGDLTNLT 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   174 DLNLGWNSlavlpdaAFRGLGSLRELVLAGNRLAYLqPALFSGLAELRELDLSRNALRAIKANVFvQLPRLQKLYLDRNL 253
Cdd:COG4886 100 ELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQ 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   254 IAAVaPGAFLGLKALRWLDLSHNRVAGLledtfpgllglrvlrlshnaiaslrPRTFKDLHFLEELQLGHNRIRQLAErS 333
Cdd:COG4886 171 LTDL-PEELGNLTNLKELDLSNNQITDL-------------------------PEPLGNLTNLEELDLSGNQLTDLPE-P 223

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   334 FEGLGQLEVLTLDHNQLQEVKagAFLGLTNVAVMNLSGNCLRNLPEQVfrGLGKLHSLHLEGSCLGRIRphtftglsgLR 413
Cdd:COG4886 224 LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK---------LK 290

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   414 RLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNR 493
Cdd:COG4886 291 ELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLG 370

                       410       420       430       440
                ....*....|....*....|....*....|....*....|...
gi 543800   494 LEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGN 536
Cdd:COG4886 371 LLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
LRRNT smart00013
Leucine rich repeat N-terminal domain;
40-78 6.55e-06

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.08  E-value: 6.55e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 543800       40 ACPAACVCSydddadELSVFCSSRNLTRLPDGVPGGTQA 78
Cdd:smart00013   1 ACPAPCNCS------GTAVDCSGRGLTEVPLDLPPDTTL 33
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
536-580 5.94e-05

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.88  E-value: 5.94e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 543800      536 NPWDCGCPLKALRDFaLQNPSAVPRFVQAICEG-DDCQPPAYTYNN 580
Cdd:smart00082   1 NPFICDCELRWLLRW-LQANEHLQDPVDLRCASpSSLRGPLLELLH 45
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-536 9.40e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.08  E-value: 9.40e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    94 FQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDglFEGLGSLW 173
Cdd:COG4886  22 TTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD--LGDLTNLT 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   174 DLNLGWNSlavlpdaAFRGLGSLRELVLAGNRLAYLqPALFSGLAELRELDLSRNALRAIKANVFvQLPRLQKLYLDRNL 253
Cdd:COG4886 100 ELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQ 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   254 IAAVaPGAFLGLKALRWLDLSHNRVAGLledtfpgllglrvlrlshnaiaslrPRTFKDLHFLEELQLGHNRIRQLAErS 333
Cdd:COG4886 171 LTDL-PEELGNLTNLKELDLSNNQITDL-------------------------PEPLGNLTNLEELDLSGNQLTDLPE-P 223

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   334 FEGLGQLEVLTLDHNQLQEVKagAFLGLTNVAVMNLSGNCLRNLPEQVfrGLGKLHSLHLEGSCLGRIRphtftglsgLR 413
Cdd:COG4886 224 LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK---------LK 290

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   414 RLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNR 493
Cdd:COG4886 291 ELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLG 370

                       410       420       430       440
                ....*....|....*....|....*....|....*....|...
gi 543800   494 LEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGN 536
Cdd:COG4886 371 LLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-523 3.10e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 89.14  E-value: 3.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800     81 LDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGL-ENLCHLHLERNQLRSLALGTFAhtPALASLGLSNNRLS 159
Cdd:PLN00113  76 LSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTsSSLRYLNLSNNNFTGSIPRGSI--PNLETLDLSNNMLS 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    160 ---RLEDGLFEglgSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA----------------YLQ--------PA 212
Cdd:PLN00113 154 geiPNDIGSFS---SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiYLGynnlsgeiPY 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    213 LFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLedtfpgllgl 292
Cdd:PLN00113 231 EIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEI---------- 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    293 rvlrlshnaiaslrPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQ-EVKAGafLG-LTNVAVMNLS 370
Cdd:PLN00113 301 --------------PELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKN--LGkHNNLTVLDLS 364

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    371 GNCLR-NLPEQVFRGlGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 449
Cdd:PLN00113 365 TNNLTgEIPEGLCSS-GNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGR 443

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 543800    450 PHRLFQGLGKLEYLLLSRNR-LAELPaDALGPlQRAFWLDVSHNRL-EALPNSLLApLGRLRYLSLRNNSLRTFTP 523
Cdd:PLN00113 444 INSRKWDMPSLQMLSLARNKfFGGLP-DSFGS-KRLENLDLSRNQFsGAVPRKLGS-LSELMQLKLSENKLSGEIP 516
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 79-256 6.02e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 68.27  E-value: 6.02e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    79 LWLDGNNLSSVP-PAAFQNLSSLgflNLQGGQLGSLEpqALLGLENLCHLHLERNQLRSlaLGTFAHTPALASLGLSNNR 157
Cdd:cd21340   7 LYLNDKNITKIDnLSLCKNLKVL---YLYDNKITKIE--NLEFLTNLTHLYLQNNQIEK--IENLENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   158 LSRLEdGLfEGLGSLWDLNLGW------NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPalFSGLAELRELDLSRNALR 231
Cdd:cd21340  80 ISVVE-GL-ENLTNLEELHIENqrlppgEKLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS 155

                       170       180
                ....*....|....*....|....*..
gi 543800   232 AIK--ANVFVQLPRLQKLYLDRNLIAA 256
Cdd:cd21340 156 DLEelLDLLSSWPSLRELDLTGNPVCK 182
LRR_8 pfam13855
Leucine rich repeat;
219-278 1.17e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 1.17e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800     219 ELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRV 278
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
40-78 6.55e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.08  E-value: 6.55e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 543800       40 ACPAACVCSydddadELSVFCSSRNLTRLPDGVPGGTQA 78
Cdd:smart00013   1 ACPAPCNCS------GTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 40-73 8.63e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 42.61  E-value: 8.63e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 543800      40 ACPAACVCSydddadELSVFCSSRNLTRLPDGVP 73
Cdd:pfam01462   1 ACPVPCHCS------ATVVNCSDRGLTAVPRDLP 28
LRRCT smart00082
Leucine rich repeat C-terminal domain;
536-580 5.94e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.88  E-value: 5.94e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 543800      536 NPWDCGCPLKALRDFaLQNPSAVPRFVQAICEG-DDCQPPAYTYNN 580
Cdd:smart00082   1 NPFICDCELRWLLRW-LQANEHLQDPVDLRCASpSSLRGPLLELLH 45
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-536 9.40e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.08  E-value: 9.40e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    94 FQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDglFEGLGSLW 173
Cdd:COG4886  22 TTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD--LGDLTNLT 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   174 DLNLGWNSlavlpdaAFRGLGSLRELVLAGNRLAYLqPALFSGLAELRELDLSRNALRAIKANVFvQLPRLQKLYLDRNL 253
Cdd:COG4886 100 ELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQ 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   254 IAAVaPGAFLGLKALRWLDLSHNRVAGLledtfpgllglrvlrlshnaiaslrPRTFKDLHFLEELQLGHNRIRQLAErS 333
Cdd:COG4886 171 LTDL-PEELGNLTNLKELDLSNNQITDL-------------------------PEPLGNLTNLEELDLSGNQLTDLPE-P 223

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   334 FEGLGQLEVLTLDHNQLQEVKagAFLGLTNVAVMNLSGNCLRNLPEQVfrGLGKLHSLHLEGSCLGRIRphtftglsgLR 413
Cdd:COG4886 224 LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK---------LK 290

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   414 RLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNR 493
Cdd:COG4886 291 ELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLG 370

                       410       420       430       440
                ....*....|....*....|....*....|....*....|...
gi 543800   494 LEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGN 536
Cdd:COG4886 371 LLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
77-283 1.85e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.15  E-value: 1.85e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    77 QALWLDGNNLSSVpPAAFQNLSSLGFLNLQGGQLGSLePQALLGLENLCHLHLERNQLRSLAlGTFAHTPALASLGLSNN 156
Cdd:COG4886 116 ESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   157 RLSRLEDGLfEGLGSLWDLNLGWNSLAVLPDaAFRGLGSLRELVLAGNRLAYLqPALfSGLAELRELDLSRNALRAIKAN 236
Cdd:COG4886 193 QITDLPEPL-GNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL-PEL-GNLTNLEELDLSNNQLTDLPPL 268

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 543800   237 vfVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLE 283
Cdd:COG4886 269 --ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
310-557 2.35e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 2.35e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   310 FKDLHFLEELQLGHNRIRQLAErSFEGLGQLEVLTLDHNQLQEVKAgAFLGLTNVAVMNLSGNCLRNLPEqVFRGLGKLH 389
Cdd:COG4886 109 LSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLK 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   390 SLHLEGSCLGRIrPHTFTGLSGLRRLFLKDNGLVGIEEqSLWGLAELLELDLTSNQLTHLPHrlFQGLGKLEYLLLSRNR 469
Cdd:COG4886 186 ELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQ 261

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   470 LAELPAdaLGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRD 549
Cdd:COG4886 262 LTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339


                ....*...
gi 543800   550 FALQNPSA 557
Cdd:COG4886 340 LALSLSLL 347
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-523 3.10e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 89.14  E-value: 3.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800     81 LDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGL-ENLCHLHLERNQLRSLALGTFAhtPALASLGLSNNRLS 159
Cdd:PLN00113  76 LSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTsSSLRYLNLSNNNFTGSIPRGSI--PNLETLDLSNNMLS 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    160 ---RLEDGLFEglgSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA----------------YLQ--------PA 212
Cdd:PLN00113 154 geiPNDIGSFS---SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiYLGynnlsgeiPY 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    213 LFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLedtfpgllgl 292
Cdd:PLN00113 231 EIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEI---------- 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    293 rvlrlshnaiaslrPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQ-EVKAGafLG-LTNVAVMNLS 370
Cdd:PLN00113 301 --------------PELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKN--LGkHNNLTVLDLS 364

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    371 GNCLR-NLPEQVFRGlGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 449
Cdd:PLN00113 365 TNNLTgEIPEGLCSS-GNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGR 443

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 543800    450 PHRLFQGLGKLEYLLLSRNR-LAELPaDALGPlQRAFWLDVSHNRL-EALPNSLLApLGRLRYLSLRNNSLRTFTP 523
Cdd:PLN00113 444 INSRKWDMPSLQMLSLARNKfFGGLP-DSFGS-KRLENLDLSRNQFsGAVPRKLGS-LSELMQLKLSENKLSGEIP 516
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-337 7.91e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 7.91e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    61 SSRNLTRLPDGVPGGT--QALWLDGNNLSSVPPAaFQNLSSLGFLNLQGGQLGSLePQALLGLENLCHLHLERNQLRSLA 138
Cdd:COG4886 121 SGNQLTDLPEELANLTnlKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLP 198

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   139 LgTFAHTPALASLGLSNNRLSRLEDGLfEGLGSLWDLNLGWNSLAVLPDaaFRGLGSLRELVLAGNRLAYLQPAlfSGLA 218
Cdd:COG4886 199 E-PLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL--ANLT 272

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   219 ELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPG-AFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRL 297
Cdd:COG4886 273 NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLiLLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 543800   298 SHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGL 337
Cdd:COG4886 353 LLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-518 2.21e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.89  E-value: 2.21e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800     61 SSRNLT-RLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLAL 139
Cdd:PLN00113 126 SNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIP 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    140 GTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE 219
Cdd:PLN00113 206 RELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQK 285

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    220 LRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH 299
Cdd:PLN00113 286 LISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLST 365

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    300 NAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLrnlpe 379
Cdd:PLN00113 366 NNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL----- 440

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    380 qvfrgLGKLHSLHLEgsclgrirphtftgLSGLRRLFLKDNGLVGiEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGK 459
Cdd:PLN00113 441 -----QGRINSRKWD--------------MPSLQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSE 500

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 543800    460 LEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL 518
Cdd:PLN00113 501 LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
309-536 1.66e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 1.66e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   309 TFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKL 388
Cdd:COG4886  19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNL 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   389 HSLHLEGSClgrirphTFTGLSGLRRLFLKDNGLVGIEEqSLWGLAELLELDLTSNQLTHLPHRLFQgLGKLEYLLLSRN 468
Cdd:COG4886  99 TELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNN 169

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 543800   469 RLAELPAdALGPLQRAFWLDVSHNRLEALPNSlLAPLGRLRYLSLRNNSLRTFTP---QPPGLERLWLEGN 536
Cdd:COG4886 170 QLTDLPE-ELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEplaNLTNLETLDLSNN 238
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 144-531 4.79e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 75.65  E-value: 4.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    144 HTPALASLGLSNNRLS-RLEDGLFEGLGSLWDLNLGWNSLA-VLPDAAFRGLGSLRelvLAGNRLAYLQPALFSGLAELR 221
Cdd:PLN00113  91 RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLD---LSNNMLSGEIPNDIGSFSSLK 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    222 ELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLedtfpgllglrvlrlshna 301
Cdd:PLN00113 168 VLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEI------------------- 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    302 iaslrPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLR-NLPEQ 380
Cdd:PLN00113 229 -----PYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPEL 303

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    381 VFRgLGKLHSLHLEGSCL-GRIrPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLT-HLPHRLFQGlG 458
Cdd:PLN00113 304 VIQ-LQNLEILHLFSNNFtGKI-PVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSS-G 380

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    459 KLEYLLLSRNRL-------------------------AELPADaLGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSL 513
Cdd:PLN00113 381 NLFKLILFSNSLegeipkslgacrslrrvrlqdnsfsGELPSE-FTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSL 459

                        410
                 ....*....|....*...
gi 543800    514 RNNSLRTFTPQPPGLERL 531
Cdd:PLN00113 460 ARNKFFGGLPDSFGSKRL 477
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 79-256 6.02e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 68.27  E-value: 6.02e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    79 LWLDGNNLSSVP-PAAFQNLSSLgflNLQGGQLGSLEpqALLGLENLCHLHLERNQLRSlaLGTFAHTPALASLGLSNNR 157
Cdd:cd21340   7 LYLNDKNITKIDnLSLCKNLKVL---YLYDNKITKIE--NLEFLTNLTHLYLQNNQIEK--IENLENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   158 LSRLEdGLfEGLGSLWDLNLGW------NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPalFSGLAELRELDLSRNALR 231
Cdd:cd21340  80 ISVVE-GL-ENLTNLEELHIENqrlppgEKLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS 155

                       170       180
                ....*....|....*....|....*..
gi 543800   232 AIK--ANVFVQLPRLQKLYLDRNLIAA 256
Cdd:cd21340 156 DLEelLDLLSSWPSLRELDLTGNPVCK 182
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
415-596 2.66e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.73  E-value: 2.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    415 LFLKDNGLVGIEEQSLwglAELLELDLTSNQLTHLPHRLFQGLGKLEyllLSRNRLAELPADALGPLQRafwLDVSHNRL 494
Cdd:PRK15370 204 LILDNNELKSLPENLQ---GNIKTLYANSNQLTSIPATLPDTIQEME---LSINRITELPERLPSALQS---LDLFHNKI 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    495 EALPNSLlaPLGrLRYLSLRNNSLRTFTPQ-PPGLERLWLEGNpwdcgcPLKALrdfalqnPSAVPRFVQAICEGDdcqp 573
Cdd:PRK15370 275 SCLPENL--PEE-LRYLSVYDNSIRTLPAHlPSGITHLNVQSN------SLTAL-------PETLPPGLKTLEAGE---- 334

                        170       180
                 ....*....|....*....|....*.
gi 543800    574 paytyNNITC---ASPPEVVGLDLRD 596
Cdd:PRK15370 335 -----NALTSlpaSLPPELQVLDVSK 355
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
65-283 1.11e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 67.80  E-value: 1.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800     65 LTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSlgfLNLQGGQLGSLePQALlgLENLCHLHLERNQLRSLAlgtfAH 144
Cdd:PRK15370 190 LTTIPACIPEQITTLILDNNELKSLPENLQGNIKT---LYANSNQLTSI-PATL--PDTIQEMELSINRITELP----ER 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    145 TP-ALASLGLSNNRLSRLEDGLFEGL------------------GSLWDLNLGWNSLAVLPDAAFRGlgsLRELVLAGNR 205
Cdd:PRK15370 260 LPsALQSLDLFHNKISCLPENLPEELrylsvydnsirtlpahlpSGITHLNVQSNSLTALPETLPPG---LKTLEAGENA 336

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    206 LAYLQPALfsgLAELRELDLSRNALRAIKANVfvqLPRLQKLYLDRNLIAAVA---PGaflglkALRWLDLSHNRVAGLL 282
Cdd:PRK15370 337 LTSLPASL---PPELQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNLPenlPA------ALQIMQASRNNLVRLP 404


                 .
gi 543800    283 E 283
Cdd:PRK15370 405 E 405
LRR_8 pfam13855
Leucine rich repeat;
219-278 1.17e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 1.17e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800     219 ELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRV 278
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 77-324 2.19e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.18  E-value: 2.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800     77 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNN 156
Cdd:PLN00113 335 QVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDN 414

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    157 RLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFsGLAELRELDLSRNALRAIKAN 236
Cdd:PLN00113 415 SFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSF-GSKRLENLDLSRNQFSGAVPR 493

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    237 VFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFL 316
Cdd:PLN00113 494 KLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESL 573


                 ....*...
gi 543800    317 EELQLGHN 324
Cdd:PLN00113 574 VQVNISHN 581
LRR_8 pfam13855
Leucine rich repeat;
195-254 2.74e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 2.74e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800     195 SLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLI 254
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
146-206 9.58e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 9.58e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 543800     146 PALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRL 206
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
300-537 1.07e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 64.72  E-value: 1.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    300 NAIASLrPRTFKDLhfLEELQLGHNRIRQLAERSFEGLgqlEVLTLDHNQLQEVKAGAFLGLTNVAVMNlsgNCLRNLPE 379
Cdd:PRK15370 230 NQLTSI-PATLPDT--IQEMELSINRITELPERLPSAL---QSLDLFHNKISCLPENLPEELRYLSVYD---NSIRTLPA 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    380 qvfrglgklhslHLEgsclgrirphtftglSGLRRLFLKDNGLVGIEEQSLWGLaELLELDltSNQLTHLPHRLFQGLGK 459
Cdd:PRK15370 301 ------------HLP---------------SGITHLNVQSNSLTALPETLPPGL-KTLEAG--ENALTSLPASLPPELQV 350

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    460 LEyllLSRNRLAELPaDALGPLQRAfwLDVSHNRLEALPNSLLAPLGRLRylSLRNN------SLRTFTPQPPGLERLWL 533
Cdd:PRK15370 351 LD---VSKNQITVLP-ETLPPTITT--LDVSRNALTNLPENLPAALQIMQ--ASRNNlvrlpeSLPHFRGEGPQPTRIIV 422


                 ....
gi 543800    534 EGNP 537
Cdd:PRK15370 423 EYNP 426
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
57-287 2.73e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.64  E-value: 2.73e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    57 SVFCSSRNLTRLPDGVPGGT--QALWLDGNNLSSVPpAAFQNLSSLGFLNLQGGQLGSLePQALLGLENLCHLHLERNQL 134
Cdd:COG4886 163 SLDLSNNQLTDLPEELGNLTnlKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQL 240

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   135 RSLAlgTFAHTPALASLGLSNNRLSRLEDGLfeGLGSLWDLNLGWNSLAVLpdaafrglgSLRELVLAGNRLAYLQPALF 214
Cdd:COG4886 241 TDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDL---------KLKELELLLGLNSLLLLLLL 307

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 543800   215 SGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFP 287
Cdd:COG4886 308 LNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLL 380
LRR_8 pfam13855
Leucine rich repeat;
387-446 7.92e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 7.92e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800     387 KLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQL 446
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 195-374 8.19e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 8.19e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   195 SLRELVLAGNRLAYLQPalFSGLAELRELDLSRNALRAIkaNVFVQLPRLQKLYLDRNLIAAVApgAFLGLKALRWLDLS 274
Cdd:cd21340  25 NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIE 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   275 HNRVA---GLLEDTFpgllglrvlrlshnAIASLRPRtfkdlhfLEELQLGHNRIRQLAErsFEGLGQLEVLTLDHNQLQ 351
Cdd:cd21340  99 NQRLPpgeKLTFDPR--------------SLAALSNS-------LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS 155

                       170       180
                ....*....|....*....|....*
gi 543800   352 EVK--AGAFLGLTNVAVMNLSGNCL 374
Cdd:cd21340 156 DLEelLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
410-470 9.17e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 9.17e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 543800     410 SGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRL 470
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
298-350 1.08e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.08e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 543800     298 SHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQL 350
Cdd:pfam13855   9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
339-395 2.32e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 2.32e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 543800     339 QLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEG 395
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 121-348 4.18e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 4.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   121 LENLCHLHLERNQLRSLalGTFAHTPALASLGLSNNRLSRLEDglFEGLGSLWDLNLGWNSLAVLPDaaFRGLGSLRELV 200
Cdd:cd21340   1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   201 LAGNRLAYLqpalfSGLA---ELRELDLSRNalraikanvfvQLPRLQKLYLDRNLIAAVApgaflglKALRWLDLSHNR 277
Cdd:cd21340  75 LGGNRISVV-----EGLEnltNLEELHIENQ-----------RLPPGEKLTFDPRSLAALS-------NSLRVLNISGNN 131

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 543800   278 vaglledtfpgllglrvlrlshnaIASLRPrtFKDLHFLEELQLGHNRIRQLAE--RSFEGLGQLEVLTLDHN 348
Cdd:cd21340 132 ------------------------IDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
242-326 7.45e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 7.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800     242 PRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRvaglledtfpgllglrvlrlshnaIASLRPRTFKDLHFLEELQL 321
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL------------------------LTTLSPGAFSGLPSLRYLDL 56


                  ....*
gi 543800     322 GHNRI 326
Cdd:pfam13855  57 SGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
175-230 1.12e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 1.12e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 543800     175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNAL 230
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
316-372 2.85e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 2.85e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 543800     316 LEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 372
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
123-182 3.24e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 3.24e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800     123 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 182
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
438-494 3.36e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 3.36e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 543800     438 ELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 494
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
103-158 5.03e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 5.03e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 543800     103 LNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRL 158
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
65-269 3.37e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 53.24  E-value: 3.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800     65 LTRLPDGVPGGTQALWLDGNNLSSVPPAAfqnlSSLGFLNLQGGQLGSLE--PQALLGL--------------ENLCHLH 128
Cdd:PRK15387 213 LTTLPDCLPAHITTLVIPDNNLTSLPALP----PELRTLEVSGNQLTSLPvlPPGLLELsifsnplthlpalpSGLCKLW 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    129 LERNQLRSLALgtfaHTPALASLGLSNNRLSRLEdGLFEGLGSLWDLNLGWNSLAVLPDAafrglgsLRELVLAGNRLAY 208
Cdd:PRK15387 289 IFGNQLTSLPV----LPPGLQELSVSDNQLASLP-ALPSELCKLWAYNNQLTSLPTLPSG-------LQELSVSDNQLAS 356

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 543800    209 LqPALFSGLAELRELDLSRNALRA---------IKANVFVQLP----RLQKLYLDRNLIAAVA--PGAFLGLKALR 269
Cdd:PRK15387 357 L-PTLPSELYKLWAYNNRLTSLPAlpsglkeliVSGNRLTSLPvlpsELKELMVSGNRLTSLPmlPSGLLSLSVYR 431
LRR_8 pfam13855
Leucine rich repeat;
81-134 5.71e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 5.71e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 543800      81 LDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQL 134
Cdd:pfam13855   8 LSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
40-78 6.55e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.08  E-value: 6.55e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 543800       40 ACPAACVCSydddadELSVFCSSRNLTRLPDGVPGGTQA 78
Cdd:smart00013   1 ACPAPCNCS------GTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 40-73 8.63e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 42.61  E-value: 8.63e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 543800      40 ACPAACVCSydddadELSVFCSSRNLTRLPDGVP 73
Cdd:pfam01462   1 ACPVPCHCS------ATVVNCSDRGLTAVPRDLP 28
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
56-219 1.03e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.54  E-value: 1.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800     56 LSVFCSSrnLTRLPDGVPGGTQALWLDGNNLSSVPpaafQNL-SSLGFLNLQGGQLGSLEPQALLGLENlchLHLERNQL 134
Cdd:PRK15370 267 LDLFHNK--ISCLPENLPEELRYLSVYDNSIRTLP----AHLpSGITHLNVQSNSLTALPETLPPGLKT---LEAGENAL 337

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    135 RSLALGTfahTPALASLGLSNNRLSRLEDGLFEglgSLWDLNLGWNSLAVLPD---AAFRGLGSLRelvlagNRLAYLQP 211
Cdd:PRK15370 338 TSLPASL---PPELQVLDVSKNQITVLPETLPP---TITTLDVSRNALTNLPEnlpAALQIMQASR------NNLVRLPE 405


                 ....*...
gi 543800    212 ALFSGLAE 219
Cdd:PRK15370 406 SLPHFRGE 413
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 271-543 1.51e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.31  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    271 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRT-FKDLHFLEELQLGHNRIRQLAERSFegLGQLEVLTLDHNQ 349
Cdd:PLN00113  74 IDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDiFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNM 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    350 L-----QEVkaGAFlglTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVG 424
Cdd:PLN00113 152 LsgeipNDI--GSF---SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSG 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    425 IEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAP 504
Cdd:PLN00113 227 EIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQ 306

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 543800    505 LGRLRYLSLRNNSLRTFTPQP----PGLERLWLEGNPWDCGCP 543
Cdd:PLN00113 307 LQNLEILHLFSNNFTGKIPVAltslPRLQVLQLWSNKFSGEIP 349
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 385-537 1.86e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 1.86e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   385 LGKLHSLHLEGSCLGRIrpHTFTGLSGLRRLFLKDNGLVGIEeqSLWGLAELLELDLTSNQLTHLPHrlFQGLGKLEYLL 464
Cdd:cd21340   1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   465 LSRNRLAE-------------------LPAD-----------ALGP-LQRafwLDVSHNRLEALpnSLLAPLGRLRYLSL 513
Cdd:cd21340  75 LGGNRISVveglenltnleelhienqrLPPGekltfdprslaALSNsLRV---LNISGNNIDSL--EPLAPLRNLEQLDA 149

                       170       180       190
                ....*....|....*....|....*....|
gi 543800   514 RNNSLRTFT------PQPPGLERLWLEGNP 537
Cdd:cd21340 150 SNNQISDLEelldllSSWPSLRELDLTGNP 179
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 313-492 2.12e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 2.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   313 LHFLEELQLGHNRIRQLaeRSFEGLGQLEVLTLDHNQLQEVKagaflGLTNvavmnlsgncLRNLPEqvfrglgklhsLH 392
Cdd:cd21340  45 LTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVE-----GLEN----------LTNLEE-----------LH 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800   393 LEGSCLGRirPHTFTglsglrrlflkdnglvgIEEQSLWGLAELLE-LDLTSNQLTHLphRLFQGLGKLEYLLLSRNRLA 471
Cdd:cd21340  97 IENQRLPP--GEKLT-----------------FDPRSLAALSNSLRvLNISGNNIDSL--EPLAPLRNLEQLDASNNQIS 155

                       170       180
                ....*....|....*....|....
gi 543800   472 ELpADALGPLQRAFWL---DVSHN 492
Cdd:cd21340 156 DL-EELLDLLSSWPSLrelDLTGN 178
LRRCT smart00082
Leucine rich repeat C-terminal domain;
536-580 5.94e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.88  E-value: 5.94e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 543800      536 NPWDCGCPLKALRDFaLQNPSAVPRFVQAICEG-DDCQPPAYTYNN 580
Cdd:smart00082   1 NPFICDCELRWLLRW-LQANEHLQDPVDLRCASpSSLRGPLLELLH 45
LRR_8 pfam13855
Leucine rich repeat;
486-537 7.95e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 7.95e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 543800     486 WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ----PPGLERLWLEGNP 537
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGafsgLPSLRYLDLSGNR 60
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
436-536 4.06e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.15  E-value: 4.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543800    436 LLELDLTSNQLTHLPhRLFQGLGKleyLLLSRNRLAELPADALGpLQRafwLDVSHNRLEALPnsllAPLGRLRYLSLRN 515
Cdd:PRK15387 264 LLELSIFSNPLTHLP-ALPSGLCK---LWIFGNQLTSLPVLPPG-LQE---LSVSDNQLASLP----ALPSELCKLWAYN 331

                         90       100
                 ....*....|....*....|.
gi 543800    516 NSLRTFTPQPPGLERLWLEGN 536
Cdd:PRK15387 332 NQLTSLPTLPSGLQELSVSDN 352
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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