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Conserved domains on  [gi|160409931|sp|P49616|]
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RecName: Full=Urokinase plasminogen activator surface receptor; Short=U-PAR; Short=uPAR; AltName: CD_antigen=CD87; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 207-295 1.35e-28

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


:

Pssm-ID: 467088  Cd Length: 93  Bit Score: 105.94  E-value: 1.35e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409931 207 QSLPPNGFQCYSCEGNSTFGCSYEETSLIDCRGPMNQCLEATGLDVLG--NRSYTVRGCATASWCQGSHVADSfQTHVNL 284
Cdd:cd23558    1 PDLPPNGIQCYSCNGNSTHGCSSEETSKVRCRGPQTQCLEATGTTAHGgkNQSYMVKGCATPSMCQSTALSLN-QVLNSA 79

                         90
                 ....*....|.
gi 160409931 285 SISCCNGSGCN 295
Cdd:cd23558   80 DVRCCNGSLCN 90
TFP_LU_ECD_uPAR_rpt2 cd23557
second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 114-199 3.95e-28

second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


:

Pssm-ID: 467087  Cd Length: 85  Bit Score: 104.33  E-value: 3.95e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409931 114 RGRYLECASCTSLDQSCERGREQSLQCRYPTEHCIEVVTLQSTERSvKDEPYTKGCGSLPGCPGTAGFHSNQTFHFLKCC 193
Cdd:cd23557    1 RSRYLECYSCGSSDMSCERGRLTSLQCRGPQDQCVDVTTHGSLERP-KSERRLKGCGTLPGCPGSLGFHNNDTFHLLKCC 79


                 ....*.
gi 160409931 194 NFTQCN 199
Cdd:cd23557   80 NSSLCN 85
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 25-102 6.69e-26

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


:

Pssm-ID: 467086  Cd Length: 79  Bit Score: 98.30  E-value: 6.69e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 160409931  25 LRCIQCESNQDCLVEE-CALGQDLCRTTVLREWEDAEELEVVTRGCAHKEKTNRTMSYRMGSVIVSLTETVCATNLCNR 102
Cdd:cd23556    1 LRCYSCKSNGDCRVEEvCALGQDLCRTTVMTLWEEGEELELVVKGCDVSGKTNASSSYRTGLNINSLQETVCSSDLCNQ 79
 
Name Accession Description Interval E-value
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 207-295 1.35e-28

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 105.94  E-value: 1.35e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409931 207 QSLPPNGFQCYSCEGNSTFGCSYEETSLIDCRGPMNQCLEATGLDVLG--NRSYTVRGCATASWCQGSHVADSfQTHVNL 284
Cdd:cd23558    1 PDLPPNGIQCYSCNGNSTHGCSSEETSKVRCRGPQTQCLEATGTTAHGgkNQSYMVKGCATPSMCQSTALSLN-QVLNSA 79

                         90
                 ....*....|.
gi 160409931 285 SISCCNGSGCN 295
Cdd:cd23558   80 DVRCCNGSLCN 90
TFP_LU_ECD_uPAR_rpt2 cd23557
second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 114-199 3.95e-28

second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467087  Cd Length: 85  Bit Score: 104.33  E-value: 3.95e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409931 114 RGRYLECASCTSLDQSCERGREQSLQCRYPTEHCIEVVTLQSTERSvKDEPYTKGCGSLPGCPGTAGFHSNQTFHFLKCC 193
Cdd:cd23557    1 RSRYLECYSCGSSDMSCERGRLTSLQCRGPQDQCVDVTTHGSLERP-KSERRLKGCGTLPGCPGSLGFHNNDTFHLLKCC 79


                 ....*.
gi 160409931 194 NFTQCN 199
Cdd:cd23557   80 NSSLCN 85
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 25-102 6.69e-26

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467086  Cd Length: 79  Bit Score: 98.30  E-value: 6.69e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 160409931  25 LRCIQCESNQDCLVEE-CALGQDLCRTTVLREWEDAEELEVVTRGCAHKEKTNRTMSYRMGSVIVSLTETVCATNLCNR 102
Cdd:cd23556    1 LRCYSCKSNGDCRVEEvCALGQDLCRTTVMTLWEEGEELELVVKGCDVSGKTNASSSYRTGLNINSLQETVCSSDLCNQ 79
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 214-295 3.28e-18

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 77.96  E-value: 3.28e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409931   214 FQCYSCEGNSTFGCSYEETslidCRGPMNQCLEATGLDVLGNR-SYTVRGCATASWCQGSHVADSFQTHVNLSISCCNGS 292
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEE----CRSPDDVCLTVVAEVISDSRgSVVYKGCATSPICPGSHGYEINLTIAFLKVSCCQTD 76


                   ...
gi 160409931   293 GCN 295
Cdd:smart00134  77 LCN 79
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 27-101 1.05e-14

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 68.33  E-value: 1.05e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 160409931   27 CIQCE--SNQDCLVE-ECALGQDLCRTTVLREWEDAEELEVVTRGCAHkEKTNRTMSYRMGSVIVSLTETVCATNLCN 101
Cdd:pfam00021   1 CYSCLgvSNEDCLSEvTCPLSDGQCVTTTLELPEGNLRGTVVSKGCAR-SSCPRLLSDFINGGIISVSESCCQSDLCN 77
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 118-199 9.33e-14

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 65.63  E-value: 9.33e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409931   118 LECASCT-SLDQSCERGREqslqCRYPTEHCIEVVTLQSTERSVKDepYTKGCGSLPGCPGTAGFHSNQTFHFLK--CCN 194
Cdd:smart00134   1 LQCYSCTgNPDSSCSSEEE----CRSPDDVCLTVVAEVISDSRGSV--VYKGCATSPICPGSHGYEINLTIAFLKvsCCQ 74


                   ....*
gi 160409931   195 FTQCN 199
Cdd:smart00134  75 TDLCN 79
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 216-295 4.02e-13

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 63.71  E-value: 4.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409931  216 CYSCEGNSTFGCSYEETslidCRGPMNQCLEATGLDVLGN--RSYTVRGCATaSWCQgSHVADSFQ-THVNLSISCCNGS 292
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVT----CPLSDGQCVTTTLELPEGNlrGTVVSKGCAR-SSCP-RLLSDFINgGIISVSESCCQSD 74


                  ...
gi 160409931  293 GCN 295
Cdd:pfam00021  75 LCN 77
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 25-107 3.28e-12

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 61.40  E-value: 3.28e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409931    25 LRCIQCESN--QDCLVEE-CALGQDLCRTTVLREWEDAEElEVVTRGCAHKEKTNRTMSYRMGSVIVSLTETVCATNLCN 101
Cdd:smart00134   1 LQCYSCTGNpdSSCSSEEeCRSPDDVCLTVVAEVISDSRG-SVVYKGCATSPICPGSHGYEINLTIAFLKVSCCQTDLCN 79


                   ....*.
gi 160409931   102 RPRPGA 107
Cdd:smart00134  80 AAGPGA 85
 
Name Accession Description Interval E-value
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 207-295 1.35e-28

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 105.94  E-value: 1.35e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409931 207 QSLPPNGFQCYSCEGNSTFGCSYEETSLIDCRGPMNQCLEATGLDVLG--NRSYTVRGCATASWCQGSHVADSfQTHVNL 284
Cdd:cd23558    1 PDLPPNGIQCYSCNGNSTHGCSSEETSKVRCRGPQTQCLEATGTTAHGgkNQSYMVKGCATPSMCQSTALSLN-QVLNSA 79

                         90
                 ....*....|.
gi 160409931 285 SISCCNGSGCN 295
Cdd:cd23558   80 DVRCCNGSLCN 90
TFP_LU_ECD_uPAR_rpt2 cd23557
second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 114-199 3.95e-28

second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467087  Cd Length: 85  Bit Score: 104.33  E-value: 3.95e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409931 114 RGRYLECASCTSLDQSCERGREQSLQCRYPTEHCIEVVTLQSTERSvKDEPYTKGCGSLPGCPGTAGFHSNQTFHFLKCC 193
Cdd:cd23557    1 RSRYLECYSCGSSDMSCERGRLTSLQCRGPQDQCVDVTTHGSLERP-KSERRLKGCGTLPGCPGSLGFHNNDTFHLLKCC 79


                 ....*.
gi 160409931 194 NFTQCN 199
Cdd:cd23557   80 NSSLCN 85
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 25-102 6.69e-26

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467086  Cd Length: 79  Bit Score: 98.30  E-value: 6.69e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 160409931  25 LRCIQCESNQDCLVEE-CALGQDLCRTTVLREWEDAEELEVVTRGCAHKEKTNRTMSYRMGSVIVSLTETVCATNLCNR 102
Cdd:cd23556    1 LRCYSCKSNGDCRVEEvCALGQDLCRTTVMTLWEEGEELELVVKGCDVSGKTNASSSYRTGLNINSLQETVCSSDLCNQ 79
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 214-295 3.28e-18

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 77.96  E-value: 3.28e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409931   214 FQCYSCEGNSTFGCSYEETslidCRGPMNQCLEATGLDVLGNR-SYTVRGCATASWCQGSHVADSFQTHVNLSISCCNGS 292
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEE----CRSPDDVCLTVVAEVISDSRgSVVYKGCATSPICPGSHGYEINLTIAFLKVSCCQTD 76


                   ...
gi 160409931   293 GCN 295
Cdd:smart00134  77 LCN 79
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 27-101 1.05e-14

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 68.33  E-value: 1.05e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 160409931   27 CIQCE--SNQDCLVE-ECALGQDLCRTTVLREWEDAEELEVVTRGCAHkEKTNRTMSYRMGSVIVSLTETVCATNLCN 101
Cdd:pfam00021   1 CYSCLgvSNEDCLSEvTCPLSDGQCVTTTLELPEGNLRGTVVSKGCAR-SSCPRLLSDFINGGIISVSESCCQSDLCN 77
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 118-199 9.33e-14

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 65.63  E-value: 9.33e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409931   118 LECASCT-SLDQSCERGREqslqCRYPTEHCIEVVTLQSTERSVKDepYTKGCGSLPGCPGTAGFHSNQTFHFLK--CCN 194
Cdd:smart00134   1 LQCYSCTgNPDSSCSSEEE----CRSPDDVCLTVVAEVISDSRGSV--VYKGCATSPICPGSHGYEINLTIAFLKvsCCQ 74


                   ....*
gi 160409931   195 FTQCN 199
Cdd:smart00134  75 TDLCN 79
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 216-295 4.02e-13

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 63.71  E-value: 4.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409931  216 CYSCEGNSTFGCSYEETslidCRGPMNQCLEATGLDVLGN--RSYTVRGCATaSWCQgSHVADSFQ-THVNLSISCCNGS 292
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVT----CPLSDGQCVTTTLELPEGNlrGTVVSKGCAR-SSCP-RLLSDFINgGIISVSESCCQSD 74


                  ...
gi 160409931  293 GCN 295
Cdd:pfam00021  75 LCN 77
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 25-107 3.28e-12

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 61.40  E-value: 3.28e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409931    25 LRCIQCESN--QDCLVEE-CALGQDLCRTTVLREWEDAEElEVVTRGCAHKEKTNRTMSYRMGSVIVSLTETVCATNLCN 101
Cdd:smart00134   1 LQCYSCTGNpdSSCSSEEeCRSPDDVCLTVVAEVISDSRG-SVVYKGCATSPICPGSHGYEINLTIAFLKVSCCQTDLCN 79


                   ....*.
gi 160409931   102 RPRPGA 107
Cdd:smart00134  80 AAGPGA 85
TFP_LU_ECD_uPAR_rpt2 cd23557
second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 210-295 1.68e-09

second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467087  Cd Length: 85  Bit Score: 53.86  E-value: 1.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409931 210 PPNGFQCYSCEGNSTfGCSYEETSLIDCRGPMNQCLEATGLDVLG--NRSYTVRGCATASWCQGSHVADSFQTHvnLSIS 287
Cdd:cd23557    1 RSRYLECYSCGSSDM-SCERGRLTSLQCRGPQDQCVDVTTHGSLErpKSERRLKGCGTLPGCPGSLGFHNNDTF--HLLK 77


                 ....*...
gi 160409931 288 CCNGSGCN 295
Cdd:cd23557   78 CCNSSLCN 85
TFP_LU_ECD_LYPD3_rpt2 cd23563
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
 211-296 2.00e-07

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467093  Cd Length: 88  Bit Score: 48.22  E-value: 2.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409931 211 PNGFQCYSCEGNSTFGCSYEETSLIDCRGPMNQCLEATGLDVLGNRS--YTVRGCATASWCQGSHVADSfqtHVNLSISC 288
Cdd:cd23563    1 PNGVECYSCVGNSRGACSPSNAPVVRCYGAYSGCFDGNVTLTIGNVTlsLPVKGCVQDGDCTRESKGGA---SVTLKGSC 77


                 ....*...
gi 160409931 289 CNGSGCNR 296
Cdd:cd23563   78 CSGNLCNS 85
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 212-289 2.81e-07

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467102  Cd Length: 80  Bit Score: 47.42  E-value: 2.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409931 212 NGFQCYSCEGNSTFGCSYEETslIDCRGPMNQCLEATGLDVLGNRS--YTVRGCATASWCQ-GSHVADSFQTHVNLSISC 288
Cdd:cd23572    1 NGLQCPACYSEGSDSCKSEET--VNCTGEETQCIEFSGTISGGGSSvkFAMKGCATESACDlGKGSLPFGGTSVNITTAT 78


                 .
gi 160409931 289 C 289
Cdd:cd23572   79 C 79
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 215-295 5.69e-07

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 46.71  E-value: 5.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409931 215 QCYSCEGNSTFGCSYEETSLIDCRGPMNQCLEATGlDVLGNRSYTVRGCATASWCQGSHVADSFQTHVNLSISCCNGSGC 294
Cdd:cd00117    2 KCYQCNSSNDPNCCNSSPTLVTCSSPETFCRKIVG-KVGGGETLVIRGCATECECGCTECCSGTGTSGTTCTSCCDTDLC 80


                 .
gi 160409931 295 N 295
Cdd:cd00117   81 N 81
TFP_LU_ECD_LYPD5_rpt2 cd23566
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and ...
 208-296 6.07e-07

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and similar proteins; LYPD5 (also called Haldisin (human antigen with LU-domains expressed in skin)) is a novel differentiation marker of stratum granulosum in squamous epithelia. LYPD5 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467096  Cd Length: 96  Bit Score: 47.02  E-value: 6.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409931 208 SLPPNGFQCYSCEGNSTFGCSYEETSLIDCRGPMNQCLEATGLDVLGNRSYTVrgcATASW-CQGSHVADSFQTHVNLSI 286
Cdd:cd23566    3 PPTPNGMECYACLSFSPDDCSPENAEKVKCHGDMTRCYEGNGTVTIGNDNFSV---PIYIKtCQAPSCTTPGSTSPWTAI 79

                         90
                 ....*....|....*
gi 160409931 287 -----SCCNGSGCNR 296
Cdd:cd23566   80 isqqgSCCSGSLCNG 94
TFP_LU_ECD_LYPD3_rpt1 cd23562
first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
 216-296 3.51e-03

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467092  Cd Length: 87  Bit Score: 36.18  E-value: 3.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160409931 216 CYSCEGNSTFGCSYEETSLIDCRGPMNQCLEATGLDVLGNRSYTV--RGCATASWCQGSHVADSFQTHVNLSISCCNGSG 293
Cdd:cd23562    3 CYSCVEEGDGGCSPAKMTTVSCAPPMNVCTEYVAAVKTSHGTLTLrkKGCGSGLPGKLDRGLTLHGLYAFIQLRACNTSL 82


                 ...
gi 160409931 294 CNR 296
Cdd:cd23562   83 CNN 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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