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Conserved domains on  [gi|34222506|sp|P59823|]
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RecName: Full=Interleukin-1 receptor accessory protein-like 1; Short=IL-1-RAPL-1; Short=IL-1RAPL-1; Short=IL1RAPL-1; AltName: Full=X-linked interleukin-1 receptor accessory protein-like 1; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig1_IL1RAPL-1_like cd05896
First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory ...
 32-136 1.87e-69

First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. IL1RAPL is encoded by a gene on the X-chromosome, this gene is wholly or partially deleted in multiple cases of non-syndromic intellectual disability. This group also contains IL1RAPL-2 which is also encoded by a gene on the X-chromosome and is a candidate for another non-syndromic intellectual disability loci.


:

Pssm-ID: 409477  Cd Length: 105  Bit Score: 221.75  E-value: 1.87e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506  32 TDWSVDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKSSGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQ 111
Cdd:cd05896   1 TDWSVDLKKYMVLAGEPVRIKCALFYGYIRTNYSMAQSAGLSLMWYKSSGPGDFEEPIIFDGVRMSKEEDSIWFRPAELQ 80

                        90       100
                ....*....|....*....|....*
gi 34222506 112 DSGLYACVIRNSTYCMKVSISLTVG 136
Cdd:cd05896  81 DSGLYTCVLRNSTYCMKVSMSLTVA 105
TIR super family cl23801
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 405-558 2.71e-19

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


The actual alignment was detected with superfamily member pfam01582:

Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 85.49  E-value: 2.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506   405 YDAYLSYTkvdpdqwnqETGEEERFALEILPDMleKHYGYKLFIPDRDLIPTGNIEDV-ARCVDQSKRLIIVMTPNYvVR 483
Cdd:pfam01582   1 YDVFLSFR---------GSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPElLSAIEKSRRSVVVLSPNY-AS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506   484 RGWSIFELETRLRNMLvTGEIKVILIE-------CSELRGIMnyqeVEALKHTIKLLT---VIKWHG----------PKC 543
Cdd:pfam01582  69 SGWCLDELVKILECAL-DLGQKVIPIFyevdpsdVRKQTGSF----GKAFKKHKKVLTeekVLKWRGalnevaniwhSKS 143

                         170
                  ....*....|....*
gi 34222506   544 NKLNSKFWKRLQYEM 558
Cdd:pfam01582 144 VSDESKFWKKIAYDI 158
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 148-234 4.31e-17

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05757:

Pssm-ID: 472250  Cd Length: 92  Bit Score: 76.59  E-value: 4.31e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506 148 MKYFEKAELSKSKEISCRDIEDFLLPTREPEILWYKECRTKAWRPSIVFKRDTLLIKEVKEDDIGNYTCELKYGG----F 223
Cdd:cd05757   1 PRYKQKLPITKGGKITCPDLDDYKNENVLPPIQWYKDCKPLQGDKRFIPKGSKLLIQNVTEEDAGNYTCKFTYTHngkqY 80

                        90
                ....*....|.
gi 34222506 224 VVRRTTELTVT 234
Cdd:cd05757  81 NVTRTISLTVT 91
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 254-350 6.99e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.50  E-value: 6.99e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506    254 VQETQLGGSANLTCRAffgySGDVSPLIYWMK-GEKFIedldenrVWESDIRILKEHLgeqevSISLIVDSVEEGDLGNY 332
Cdd:smart00410   3 SVTVKEGESVTLSCEA----SGSPPPEVTWYKqGGKLL-------AESGRFSVSRSGS-----TSTLTISNVTPEDSGTY 66

                           90
                   ....*....|....*...
gi 34222506    333 SCYVENGNGRRHASVLLH 350
Cdd:smart00410  67 TCAATNSSGSASSGTTLT 84
 
Name Accession Description Interval E-value
Ig1_IL1RAPL-1_like cd05896
First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory ...
 32-136 1.87e-69

First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. IL1RAPL is encoded by a gene on the X-chromosome, this gene is wholly or partially deleted in multiple cases of non-syndromic intellectual disability. This group also contains IL1RAPL-2 which is also encoded by a gene on the X-chromosome and is a candidate for another non-syndromic intellectual disability loci.


Pssm-ID: 409477  Cd Length: 105  Bit Score: 221.75  E-value: 1.87e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506  32 TDWSVDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKSSGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQ 111
Cdd:cd05896   1 TDWSVDLKKYMVLAGEPVRIKCALFYGYIRTNYSMAQSAGLSLMWYKSSGPGDFEEPIIFDGVRMSKEEDSIWFRPAELQ 80

                        90       100
                ....*....|....*....|....*
gi 34222506 112 DSGLYACVIRNSTYCMKVSISLTVG 136
Cdd:cd05896  81 DSGLYTCVLRNSTYCMKVSMSLTVA 105
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 405-558 2.71e-19

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 85.49  E-value: 2.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506   405 YDAYLSYTkvdpdqwnqETGEEERFALEILPDMleKHYGYKLFIPDRDLIPTGNIEDV-ARCVDQSKRLIIVMTPNYvVR 483
Cdd:pfam01582   1 YDVFLSFR---------GSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPElLSAIEKSRRSVVVLSPNY-AS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506   484 RGWSIFELETRLRNMLvTGEIKVILIE-------CSELRGIMnyqeVEALKHTIKLLT---VIKWHG----------PKC 543
Cdd:pfam01582  69 SGWCLDELVKILECAL-DLGQKVIPIFyevdpsdVRKQTGSF----GKAFKKHKKVLTeekVLKWRGalnevaniwhSKS 143

                         170
                  ....*....|....*
gi 34222506   544 NKLNSKFWKRLQYEM 558
Cdd:pfam01582 144 VSDESKFWKKIAYDI 158
TIR smart00255
Toll - interleukin 1 - resistance;
405-559 4.86e-18

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 81.22  E-value: 4.86e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506    405 YDAYLSYTKVDPdqwnqetgeeerFALEILPDMLEKHYGYKLFIPDRDLIP-TGNIEDVARCVDQSKRLIIVMTPNYvVR 483
Cdd:smart00255   2 YDVFISYSGKED------------VRNEFLSHLLEKLRGYGLCVFIDDFEPgGGDLEEIDEAIEKSRIAIVVLSPNY-AE 68

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 34222506    484 RGWSIFELETRLRNMLVTGEIKVILIECSElrgimNYQEVEALKHTIKLL---TVIKWHGPKCNklnsKFWKRLQYEMP 559
Cdd:smart00255  69 SEWCLDELVAALENALEEGGLRVIPIFYEV-----IPSDVRKQPGKFRKVfkkNYLKWPEDEKE----QFWKKALYAVP 138
Ig2_IL1R-like cd05757
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 148-234 4.31e-17

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409415  Cd Length: 92  Bit Score: 76.59  E-value: 4.31e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506 148 MKYFEKAELSKSKEISCRDIEDFLLPTREPEILWYKECRTKAWRPSIVFKRDTLLIKEVKEDDIGNYTCELKYGG----F 223
Cdd:cd05757   1 PRYKQKLPITKGGKITCPDLDDYKNENVLPPIQWYKDCKPLQGDKRFIPKGSKLLIQNVTEEDAGNYTCKFTYTHngkqY 80

                        90
                ....*....|.
gi 34222506 224 VVRRTTELTVT 234
Cdd:cd05757  81 NVTRTISLTVT 91
PHA02785 PHA02785
IL-beta-binding protein; Provisional
 9-334 8.21e-17

IL-beta-binding protein; Provisional


Pssm-ID: 165149 [Multi-domain]  Cd Length: 326  Bit Score: 81.99  E-value: 8.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506    9 ILLYATFTQSLkvvtkrgSADGCTDWSVDIKKYQVLVGEPVRIKCALFyGYIRTNYSLaqsagLSLMWYKSSGPGDFEEP 88
Cdd:PHA02785  11 IFFYSSFVQTF-------NAPECIDKGQYFASFMELENEPVILPCPQI-NTLSSGYNI-----LDILWEKRGADNDRIIP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506   89 IAfDGSRMskeedsIWFRPTLlQDSGLYACVIRNSTYCMKVSISLT---VGENDTGLcynskMKYFEKAELSKSKEISCR 165
Cdd:PHA02785  78 ID-NGSNM------LILNPTQ-SDSGIYICITKNETYCDMMSLNLTivsVSESNIDL-----ISYPQIVNERSTGEMVCP 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506  166 DIEDFLLPTREPEILW--YKECRTKAWR---PSIVfkrdtlLIKEVKEDDIGNYTCELK--YGG--FVVRRTTELTVTAP 236
Cdd:PHA02785 145 NINAFIASNVNADIIWsgHRRLRNKRLKqrtPGII------TIEDVRKNDAGYYTCVLKyiYGDktYNVTRIVKLEVRDR 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506  237 LTdkPPKLLYPmesklTVQETQLGGSANLTCRAFFgYSGDVSPLIYWMKGEKFIEDLDE---------NRVWESDIRilk 307
Cdd:PHA02785 219 II--PPTMQLP-----EGVVTSIGSNLTIACRVSL-RPPTTDADVFWISNGMYYEEDDEdgdgrisvaNKIYTTDKR--- 287

                        330       340
                 ....*....|....*....|....*..
gi 34222506  308 ehlgeQEVSISLIVDSVEEGDLGNYSC 334
Cdd:PHA02785 288 -----RVITSRLNINPVKEEDATTFTC 309
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 254-350 6.99e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.50  E-value: 6.99e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506    254 VQETQLGGSANLTCRAffgySGDVSPLIYWMK-GEKFIedldenrVWESDIRILKEHLgeqevSISLIVDSVEEGDLGNY 332
Cdd:smart00410   3 SVTVKEGESVTLSCEA----SGSPPPEVTWYKqGGKLL-------AESGRFSVSRSGS-----TSTLTISNVTPEDSGTY 66

                           90
                   ....*....|....*...
gi 34222506    333 SCYVENGNGRRHASVLLH 350
Cdd:smart00410  67 TCAATNSSGSASSGTTLT 84
I-set pfam07679
Immunoglobulin I-set domain;
248-350 7.82e-07

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 47.64  E-value: 7.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506   248 MESKLTVQETQLGGSANLTCRAffgySGDVSPLIYWMKGEKFIEDldenrvwESDIRILKEhlgeqEVSISLIVDSVEEG 327
Cdd:pfam07679   3 FTQKPKDVEVQEGESARFTCTV----TGTPDPEVSWFKDGQPLRS-------SDRFKVTYE-----GGTYTLTISNVQPD 66

                          90       100
                  ....*....|....*....|...
gi 34222506   328 DLGNYSCYVENGNGRRHASVLLH 350
Cdd:pfam07679  67 DSGKYTCVATNSAGEAEASAELT 89
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 263-346 4.25e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 41.93  E-value: 4.25e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506 263 ANLTCRAffgySGDVSPLIYWMKGEKFIEDLDENRVwesdirilkehlGEQEVSISLIVDSVEEGDLGNYSCYVENGNGR 342
Cdd:cd00096   1 VTLTCSA----SGNPPPTITWYKNGKPLPPSSRDSR------------RSELGNGTLTISNVTLEDSGTYTCVASNSAGG 64


                ....
gi 34222506 343 RHAS 346
Cdd:cd00096  65 SASA 68
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 176-233 5.98e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 5.98e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 34222506    176 EPEILWYKECRTK-AWRPSIVFKRD----TLLIKEVKEDDIGNYTCELKYGGFVVRRTTELTV 233
Cdd:smart00410  23 PPEVTWYKQGGKLlAESGRFSVSRSgstsTLTISNVTPEDSGTYTCAATNSSGSASSGTTLTV 85
Ig_6 pfam18452
Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 ...
 76-121 7.47e-05

Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nine beta-strands and contains at least one intra-domain disulfide bond.


Pssm-ID: 465773  Cd Length: 128  Bit Score: 42.79  E-value: 7.47e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 34222506    76 WYKSSGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIR 121
Cdd:pfam18452  48 WYWQPKNGDPLEAITESSPHIIQEGNALWFLPVGVNDSGSYICRPR 93
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 176-233 1.58e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 37.76  E-value: 1.58e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 34222506   176 EPEILWYKECRTKAWRPSivfkrdtLLIKEVKEDDIGNYTCELKYG-GFVVRRTTELTV 233
Cdd:pfam13895  28 PPSYTWYKDGSAISSSPN-------FFTLSVSAEDSGTYTCVARNGrGGKVSNPVELTV 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 39-135 1.70e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.87  E-value: 1.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506     39 KKYQVLVGEPVRIKCalfygyirtnySLAQSAGLSLMWYKSSGpgdfeEPIAFDG---SRMSKEEDSIWFRPTLLQDSGL 115
Cdd:smart00410   2 PSVTVKEGESVTLSC-----------EASGSPPPEVTWYKQGG-----KLLAESGrfsVSRSGSTSTLTISNVTPEDSGT 65

                           90       100
                   ....*....|....*....|
gi 34222506    116 YACVIRNSTYCMKVSISLTV 135
Cdd:smart00410  66 YTCAATNSSGSASSGTTLTV 85
 
Name Accession Description Interval E-value
Ig1_IL1RAPL-1_like cd05896
First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory ...
 32-136 1.87e-69

First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. IL1RAPL is encoded by a gene on the X-chromosome, this gene is wholly or partially deleted in multiple cases of non-syndromic intellectual disability. This group also contains IL1RAPL-2 which is also encoded by a gene on the X-chromosome and is a candidate for another non-syndromic intellectual disability loci.


Pssm-ID: 409477  Cd Length: 105  Bit Score: 221.75  E-value: 1.87e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506  32 TDWSVDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKSSGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQ 111
Cdd:cd05896   1 TDWSVDLKKYMVLAGEPVRIKCALFYGYIRTNYSMAQSAGLSLMWYKSSGPGDFEEPIIFDGVRMSKEEDSIWFRPAELQ 80

                        90       100
                ....*....|....*....|....*
gi 34222506 112 DSGLYACVIRNSTYCMKVSISLTVG 136
Cdd:cd05896  81 DSGLYTCVLRNSTYCMKVSMSLTVA 105
Ig1_IL1R_like cd05756
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 32-136 6.66e-42

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409414  Cd Length: 96  Bit Score: 147.19  E-value: 6.66e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506  32 TDWSVDIKKYQVLVGEPVRIKCALFYGYirtnysLAQSAGLSLMWYKSsgpgDFEEPIAFD-GSRMSKEEDSIWFRPTLL 110
Cdd:cd05756   1 DEWGEDIKILVVLEGEPDVIKCPLFPNF------LAQSAGLNLTWYKN----DSETPISFEpDSRIHQEKDKLWFVPALL 70

                        90       100
                ....*....|....*....|....*.
gi 34222506 111 QDSGLYACVIRNSTYCMKVSISLTVG 136
Cdd:cd05756  71 EDSGNYYCVVRNSTYCSKVSISLEVV 96
Ig1_IL1R_like cd20992
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 33-135 2.09e-32

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409584  Cd Length: 108  Bit Score: 120.80  E-value: 2.09e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506  33 DWSVD-IKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKSSGPGDFEEPIAFD--GSRMSKEEDSIWFRPTL 109
Cdd:cd20992   2 DWGLDtMRQIQVFEGEPARIKCPLFEHFLKYNYSTAHSAGLTLIWYWTRQDRDLEEPINFRlpDNRISKEKDVLWFRPTL 81

                        90       100
                ....*....|....*....|....*.
gi 34222506 110 LQDSGLYACVIRNSTYCMKVSISLTV 135
Cdd:cd20992  82 LNDTGNYTCMLRNTTYCSKVAFPLEV 107
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 405-558 2.71e-19

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 85.49  E-value: 2.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506   405 YDAYLSYTkvdpdqwnqETGEEERFALEILPDMleKHYGYKLFIPDRDLIPTGNIEDV-ARCVDQSKRLIIVMTPNYvVR 483
Cdd:pfam01582   1 YDVFLSFR---------GSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPElLSAIEKSRRSVVVLSPNY-AS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506   484 RGWSIFELETRLRNMLvTGEIKVILIE-------CSELRGIMnyqeVEALKHTIKLLT---VIKWHG----------PKC 543
Cdd:pfam01582  69 SGWCLDELVKILECAL-DLGQKVIPIFyevdpsdVRKQTGSF----GKAFKKHKKVLTeekVLKWRGalnevaniwhSKS 143

                         170
                  ....*....|....*
gi 34222506   544 NKLNSKFWKRLQYEM 558
Cdd:pfam01582 144 VSDESKFWKKIAYDI 158
TIR smart00255
Toll - interleukin 1 - resistance;
405-559 4.86e-18

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 81.22  E-value: 4.86e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506    405 YDAYLSYTKVDPdqwnqetgeeerFALEILPDMLEKHYGYKLFIPDRDLIP-TGNIEDVARCVDQSKRLIIVMTPNYvVR 483
Cdd:smart00255   2 YDVFISYSGKED------------VRNEFLSHLLEKLRGYGLCVFIDDFEPgGGDLEEIDEAIEKSRIAIVVLSPNY-AE 68

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 34222506    484 RGWSIFELETRLRNMLVTGEIKVILIECSElrgimNYQEVEALKHTIKLL---TVIKWHGPKCNklnsKFWKRLQYEMP 559
Cdd:smart00255  69 SEWCLDELVAALENALEEGGLRVIPIFYEV-----IPSDVRKQPGKFRKVfkkNYLKWPEDEKE----QFWKKALYAVP 138
Ig2_IL1R-like cd05757
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 148-234 4.31e-17

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409415  Cd Length: 92  Bit Score: 76.59  E-value: 4.31e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506 148 MKYFEKAELSKSKEISCRDIEDFLLPTREPEILWYKECRTKAWRPSIVFKRDTLLIKEVKEDDIGNYTCELKYGG----F 223
Cdd:cd05757   1 PRYKQKLPITKGGKITCPDLDDYKNENVLPPIQWYKDCKPLQGDKRFIPKGSKLLIQNVTEEDAGNYTCKFTYTHngkqY 80

                        90
                ....*....|.
gi 34222506 224 VVRRTTELTVT 234
Cdd:cd05757  81 NVTRTISLTVT 91
PHA02785 PHA02785
IL-beta-binding protein; Provisional
 9-334 8.21e-17

IL-beta-binding protein; Provisional


Pssm-ID: 165149 [Multi-domain]  Cd Length: 326  Bit Score: 81.99  E-value: 8.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506    9 ILLYATFTQSLkvvtkrgSADGCTDWSVDIKKYQVLVGEPVRIKCALFyGYIRTNYSLaqsagLSLMWYKSSGPGDFEEP 88
Cdd:PHA02785  11 IFFYSSFVQTF-------NAPECIDKGQYFASFMELENEPVILPCPQI-NTLSSGYNI-----LDILWEKRGADNDRIIP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506   89 IAfDGSRMskeedsIWFRPTLlQDSGLYACVIRNSTYCMKVSISLT---VGENDTGLcynskMKYFEKAELSKSKEISCR 165
Cdd:PHA02785  78 ID-NGSNM------LILNPTQ-SDSGIYICITKNETYCDMMSLNLTivsVSESNIDL-----ISYPQIVNERSTGEMVCP 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506  166 DIEDFLLPTREPEILW--YKECRTKAWR---PSIVfkrdtlLIKEVKEDDIGNYTCELK--YGG--FVVRRTTELTVTAP 236
Cdd:PHA02785 145 NINAFIASNVNADIIWsgHRRLRNKRLKqrtPGII------TIEDVRKNDAGYYTCVLKyiYGDktYNVTRIVKLEVRDR 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506  237 LTdkPPKLLYPmesklTVQETQLGGSANLTCRAFFgYSGDVSPLIYWMKGEKFIEDLDE---------NRVWESDIRilk 307
Cdd:PHA02785 219 II--PPTMQLP-----EGVVTSIGSNLTIACRVSL-RPPTTDADVFWISNGMYYEEDDEdgdgrisvaNKIYTTDKR--- 287

                        330       340
                 ....*....|....*....|....*..
gi 34222506  308 ehlgeQEVSISLIVDSVEEGDLGNYSC 334
Cdd:PHA02785 288 -----RVITSRLNINPVKEEDATTFTC 309
Ig1_IL1R_like cd20991
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 73-132 1.58e-11

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. IL-1 receptor antagonist (IL-1RA), a naturally occurring cytokine, is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409583  Cd Length: 91  Bit Score: 60.77  E-value: 1.58e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 34222506  73 SLMWYKSsgpgDFEEPIAFD-GSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSIS 132
Cdd:cd20991  31 TITWYKN----DSKTPISMEqDSRIHQYKEKLWFVPAKVEDSGHYYCVVRNSTYCLKIKIT 87
Ig2_IL-1RAP_like cd20993
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 160-235 1.06e-07

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409585  Cd Length: 93  Bit Score: 50.28  E-value: 1.06e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 34222506 160 KEISCRDIEDFLLPTREPEILWYKECRTKAWRPSIVFKRDTLLIKEVKEDDIGNYTCELKY--GGFVVRRTTELTVTA 235
Cdd:cd20993  14 RTITCPDLDGIKPPSVSPTVTWYHECNAFGNFNDRVPKGDKLVIHVMLEHYQGNYTCVVTYetKGRTIKLTRTVNVKV 91
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 254-350 6.99e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.50  E-value: 6.99e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506    254 VQETQLGGSANLTCRAffgySGDVSPLIYWMK-GEKFIedldenrVWESDIRILKEHLgeqevSISLIVDSVEEGDLGNY 332
Cdd:smart00410   3 SVTVKEGESVTLSCEA----SGSPPPEVTWYKqGGKLL-------AESGRFSVSRSGS-----TSTLTISNVTPEDSGTY 66

                           90
                   ....*....|....*...
gi 34222506    333 SCYVENGNGRRHASVLLH 350
Cdd:smart00410  67 TCAATNSSGSASSGTTLT 84
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 423-511 7.48e-07

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 48.47  E-value: 7.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506   423 TGEEERFALEILPDmLEKHyGYKLFIPDRDLIPTGNIED-VARCVDQSKRLIIVMTPNYvVRRGWSIFELETRLRnmLVT 501
Cdd:pfam13676   6 AGEDRAWAEWLADA-LEAA-GYRVWLDRWDIRPGDDWVEeIEEAIENSDRVLVVLSPNY-LESPWCRAEWEAALA--DPE 80

                          90
                  ....*....|..
gi 34222506   502 GEIKVI--LIEC 511
Cdd:pfam13676  81 GRKRLIpvRLEC 92
I-set pfam07679
Immunoglobulin I-set domain;
248-350 7.82e-07

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 47.64  E-value: 7.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506   248 MESKLTVQETQLGGSANLTCRAffgySGDVSPLIYWMKGEKFIEDldenrvwESDIRILKEhlgeqEVSISLIVDSVEEG 327
Cdd:pfam07679   3 FTQKPKDVEVQEGESARFTCTV----TGTPDPEVSWFKDGQPLRS-------SDRFKVTYE-----GGTYTLTISNVQPD 66

                          90       100
                  ....*....|....*....|...
gi 34222506   328 DLGNYSCYVENGNGRRHASVLLH 350
Cdd:pfam07679  67 DSGKYTCVATNSAGEAEASAELT 89
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 241-338 2.61e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 45.63  E-value: 2.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506   241 PPKLLYPMESkltvQETQLGGSANLTCRAffgySGDVSPLIYWMKGEKFIEDLDENRVWESDirilkehlgeqeVSISLI 320
Cdd:pfam13927   1 KPVITVSPSS----VTVREGETVTLTCEA----TGSPPPTITWYKNGEPISSGSTRSRSLSG------------SNSTLT 60

                          90
                  ....*....|....*...
gi 34222506   321 VDSVEEGDLGNYSCYVEN 338
Cdd:pfam13927  61 ISNVTRSDAGTYTCVASN 78
Ig2_IL1R_like cd20994
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 148-233 2.74e-06

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409586  Cd Length: 94  Bit Score: 46.30  E-value: 2.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506 148 MKYFEKAELSKSKEISCRDIEDFLLPTRE-PEILWYKECRT---KAWRpsIVFKRDTLLIKEVKEDDIGNYTCELKY--- 220
Cdd:cd20994   1 DFYKQKVPFTSGGRIVCPHLDFFKDENNNlPKVQWYKDCKPlllDDKR--FAGLESDLLIFNVTVQDQGNYTCHTSYtym 78

                        90
                ....*....|....
gi 34222506 221 -GGFVVRRTTELTV 233
Cdd:cd20994  79 gKQYNISRTISLIV 92
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 256-341 1.33e-05

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 44.11  E-value: 1.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506   256 ETQLGGSANLTCRAFFGYSGdvsPLIYWMKGEKFIEDLDENRVWESDIRIlkehlgeqevsISLIVDSVEEGDLGNYSCY 335
Cdd:pfam00047   7 TVLEGDSATLTCSASTGSPG---PDVTWSKEGGTLIESLKVKHDNGRTTQ-----------SSLLISNVTKEDAGTYTCV 72


                  ....*.
gi 34222506   336 VENGNG 341
Cdd:pfam00047  73 VNNPGG 78
PHA02826 PHA02826
IL-1 receptor-like protein; Provisional
 46-221 3.06e-05

IL-1 receptor-like protein; Provisional


Pssm-ID: 165173 [Multi-domain]  Cd Length: 227  Bit Score: 45.68  E-value: 3.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506   46 GEPVRIKCAL--------FYGYIRTNYSLAQSAGLSLMWYKSSGPGDFEEPIAFD--GSRmskeEDSIWFRPTLLQDSGL 115
Cdd:PHA02826  37 GDPMVLLCTGkhykksifFDKTFITSYNVTWSKTDSLAFVRDSGARTKIKKITHNeiGDR----SENLWIGNVINIDEGI 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506  116 YACVIRNSTYCMKVSISLTVGENDTGLCYNSkmkyfekaelSKSKEISCRDIEDFLLPTREPEILWYKECRTKAWRPSIV 195
Cdd:PHA02826 113 YICTISSGNICEESTIRLTFDSGTINYQFNS----------GKDSKLHCYGTDGISSTFKDYTLTWYKNGNIVLYTDRIQ 182

                        170       180
                 ....*....|....*....|....*...
gi 34222506  196 FKRD--TLLIKEVKEDDIGNYTCELKYG 221
Cdd:PHA02826 183 LRNNnsTLVIKSATHDDSGIYTCNLRFN 210
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 263-346 4.25e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 41.93  E-value: 4.25e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506 263 ANLTCRAffgySGDVSPLIYWMKGEKFIEDLDENRVwesdirilkehlGEQEVSISLIVDSVEEGDLGNYSCYVENGNGR 342
Cdd:cd00096   1 VTLTCSA----SGNPPPTITWYKNGKPLPPSSRDSR------------RSELGNGTLTISNVTLEDSGTYTCVASNSAGG 64


                ....
gi 34222506 343 RHAS 346
Cdd:cd00096  65 SASA 68
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 176-233 5.98e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 5.98e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 34222506    176 EPEILWYKECRTK-AWRPSIVFKRD----TLLIKEVKEDDIGNYTCELKYGGFVVRRTTELTV 233
Cdd:smart00410  23 PPEVTWYKQGGKLlAESGRFSVSRSgstsTLTISNVTPEDSGTYTCAATNSSGSASSGTTLTV 85
Ig_6 pfam18452
Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 ...
 76-121 7.47e-05

Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nine beta-strands and contains at least one intra-domain disulfide bond.


Pssm-ID: 465773  Cd Length: 128  Bit Score: 42.79  E-value: 7.47e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 34222506    76 WYKSSGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIR 121
Cdd:pfam18452  48 WYWQPKNGDPLEAITESSPHIIQEGNALWFLPVGVNDSGSYICRPR 93
IgI_3_RPTP_IIa_LAR_like cd05739
Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F ...
 253-295 8.21e-04

Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains; The members here are composed of the third immunoglobulin (Ig)-like domain found in the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR. LAR belongs to the RPTP type IIa subfamily. Members of this subfamily are cell adhesion molecule-like proteins involved in central nervous system (CNS) development. They have large extracellular portions comprised of multiple Ig-like domains and two to nine fibronectin type III (FNIII) domains and a cytoplasmic portion having two tandem phosphatase domains. Included in this group is Drosophila LAR (DLAR).


Pssm-ID: 409401  Cd Length: 82  Bit Score: 38.73  E-value: 8.21e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 34222506 253 TVQETQLGGSANLTCRAFfgysGDVSPLIYWMKGEKFIEDLDE 295
Cdd:cd05739   5 SNHEVMPGGSVNLTCVAV----GAPMPYVKWMKGGEELTKEDE 43
Ig_C5_MyBP-C cd05894
C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C); The members here ...
 274-349 1.11e-03

C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C); The members here are composed of the C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C). MyBP-C consists of repeated domains, Ig and fibronectin type 3, and various linkers. Three isoforms of MYBP-C exist: slow-skeletal (ssMyBP-C), fast-skeletal (fsMyBP-C), and cardiac (cMyBP-C). cMYBP-C has insertions between and inside domains and an additional cardiac-specific Ig domain at the N-terminus. For cMYBP_C an interaction has been demonstrated between this C5 domain and the Ig C8 domain.


Pssm-ID: 409475  Cd Length: 86  Bit Score: 38.67  E-value: 1.11e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 34222506 274 SGDVSPLIYWMKGEKFIEDlDENRVwesdirilkeHLGEQEVSISLIVDSVEEGDLGNYSCYVENGNGRRHASVLL 349
Cdd:cd05894  20 SGEPAPTVTWSRGDKAFTA-TEGRV----------RVESYKDLSSFVIEGAEREDEGVYTITVTNPVGEDHASLFV 84
IgI_3_Robo cd05725
Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...
 255-349 1.26e-03

Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, Robo3), and three mammalian Slit homologs (Slit-1,Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, and Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409390 [Multi-domain]  Cd Length: 83  Bit Score: 38.15  E-value: 1.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506 255 QETQLGGSANLTCRAffgySGDVSPLIYWMKgekfiedlDENRVWESDIRILKEHlgeqevsiSLIVDSVEEGDLGNYSC 334
Cdd:cd05725   7 QVVLVDDSAEFQCEV----GGDPVPTVRWRK--------EDGELPKGRYEILDDH--------SLKIRKVTAGDMGSYTC 66

                        90
                ....*....|....*
gi 34222506 335 YVENGNGRRHASVLL 349
Cdd:cd05725  67 VAENMVGKIEASATL 81
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 176-233 1.58e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 37.76  E-value: 1.58e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 34222506   176 EPEILWYKECRTKAWRPSivfkrdtLLIKEVKEDDIGNYTCELKYG-GFVVRRTTELTV 233
Cdd:pfam13895  28 PPSYTWYKDGSAISSSPN-------FFTLSVSAEDSGTYTCVARNGrGGKVSNPVELTV 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 39-135 1.70e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.87  E-value: 1.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34222506     39 KKYQVLVGEPVRIKCalfygyirtnySLAQSAGLSLMWYKSSGpgdfeEPIAFDG---SRMSKEEDSIWFRPTLLQDSGL 115
Cdd:smart00410   2 PSVTVKEGESVTLSC-----------EASGSPPPEVTWYKQGG-----KLLAESGrfsVSRSGSTSTLTISNVTPEDSGT 65

                           90       100
                   ....*....|....*....|
gi 34222506    116 YACVIRNSTYCMKVSISLTV 135
Cdd:smart00410  66 YTCAATNSSGSASSGTTLTV 85
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 176-217 6.26e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 35.77  E-value: 6.26e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 34222506 176 EPEILWYKE----CRTKAWRPSIVFKRDTLLIKEVKEDDIGNYTCE 217
Cdd:cd00096  12 PPTITWYKNgkplPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCV 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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