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Conserved domains on  [gi|3023286|sp|P70075|]
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RecName: Full=Annexin A5; AltName: Full=Annexin V; AltName: Full=Annexin-5

Protein Classification

annexin( domain architecture ID 10446041)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity

CATH:  1.10.220.10
Gene Ontology:  GO:0005509|GO:0005544|GO:0048306|GO:0003723
PubMed:  15059252|1646719
SCOP:  4001063
TCDB:  1.A.31

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 22-86 1.53e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 96.77  E-value: 1.53e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3023286     22 DAETLRHAMKGLGTDEDTILKLLISRSNKQRQQIALTYKTLFGRDLTDDLKSELSGKFETLLVAL 86
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 252-317 2.86e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 93.69  E-value: 2.86e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3023286    252 YLAEVLYNSMKGAGTDDQTLIRVLVSRSEIDLFNIRQTFRKHYGKSLHAMIQSDTSGDYRNALLLL 317
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 93-158 7.68e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 87.14  E-value: 7.68e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3023286     93 YDACELRNAIKGLGTLENVIIEIMASRTAAEVKNIKETYKKEFDSDLEKDIVGDTSGNFERLLVSL 158
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 177-242 1.73e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 80.60  E-value: 1.73e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3023286    177 DAKALfDAGENKWGTDEETFISILSTRGVGHLRKVFDQYMTISGYQIEESIQSETGGHFEKLLLAV 242
Cdd:pfam00191   2 DAELL-RKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 22-86 1.53e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 96.77  E-value: 1.53e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3023286     22 DAETLRHAMKGLGTDEDTILKLLISRSNKQRQQIALTYKTLFGRDLTDDLKSELSGKFETLLVAL 86
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 252-317 2.86e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 93.69  E-value: 2.86e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3023286    252 YLAEVLYNSMKGAGTDDQTLIRVLVSRSEIDLFNIRQTFRKHYGKSLHAMIQSDTSGDYRNALLLL 317
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 93-158 7.68e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 87.14  E-value: 7.68e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3023286     93 YDACELRNAIKGLGTLENVIIEIMASRTAAEVKNIKETYKKEFDSDLEKDIVGDTSGNFERLLVSL 158
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
265-317 5.27e-21

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 84.38  E-value: 5.27e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 3023286     265 GTDDQTLIRVLVSRSEIDLFNIRQTFRKHYGKSLHAMIQSDTSGDYRNALLLL 317
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
34-86 6.41e-20

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 81.68  E-value: 6.41e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 3023286      34 GTDEDTILKLLISRSNKQRQQIALTYKTLFGRDLTDDLKSELSGKFETLLVAL 86
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 177-242 1.73e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 80.60  E-value: 1.73e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3023286    177 DAKALfDAGENKWGTDEETFISILSTRGVGHLRKVFDQYMTISGYQIEESIQSETGGHFEKLLLAV 242
Cdd:pfam00191   2 DAELL-RKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
106-158 2.05e-18

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 77.45  E-value: 2.05e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 3023286     106 GTLENVIIEIMASRTAAEVKNIKETYKKEFDSDLEKDIVGDTSGNFERLLVSL 158
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
190-242 7.28e-16

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 70.51  E-value: 7.28e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 3023286     190 GTDEETFISILSTRGVGHLRKVFDQYMTISGYQIEESIQSETGGHFEKLLLAV 242
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 22-86 1.53e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 96.77  E-value: 1.53e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3023286     22 DAETLRHAMKGLGTDEDTILKLLISRSNKQRQQIALTYKTLFGRDLTDDLKSELSGKFETLLVAL 86
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 252-317 2.86e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 93.69  E-value: 2.86e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3023286    252 YLAEVLYNSMKGAGTDDQTLIRVLVSRSEIDLFNIRQTFRKHYGKSLHAMIQSDTSGDYRNALLLL 317
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 93-158 7.68e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 87.14  E-value: 7.68e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3023286     93 YDACELRNAIKGLGTLENVIIEIMASRTAAEVKNIKETYKKEFDSDLEKDIVGDTSGNFERLLVSL 158
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
265-317 5.27e-21

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 84.38  E-value: 5.27e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 3023286     265 GTDDQTLIRVLVSRSEIDLFNIRQTFRKHYGKSLHAMIQSDTSGDYRNALLLL 317
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
34-86 6.41e-20

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 81.68  E-value: 6.41e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 3023286      34 GTDEDTILKLLISRSNKQRQQIALTYKTLFGRDLTDDLKSELSGKFETLLVAL 86
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 177-242 1.73e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 80.60  E-value: 1.73e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3023286    177 DAKALfDAGENKWGTDEETFISILSTRGVGHLRKVFDQYMTISGYQIEESIQSETGGHFEKLLLAV 242
Cdd:pfam00191   2 DAELL-RKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
106-158 2.05e-18

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 77.45  E-value: 2.05e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 3023286     106 GTLENVIIEIMASRTAAEVKNIKETYKKEFDSDLEKDIVGDTSGNFERLLVSL 158
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
190-242 7.28e-16

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 70.51  E-value: 7.28e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 3023286     190 GTDEETFISILSTRGVGHLRKVFDQYMTISGYQIEESIQSETGGHFEKLLLAV 242
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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