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Conserved domains on  [gi|74834687|sp|P90698|]
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RecName: Full=Cystatin cpi-1; Flags: Precursor

Protein Classification

CY domain-containing protein( domain architecture ID 10036424)

CY domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 30-125 4.28e-31

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


:

Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 106.79  E-value: 4.28e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74834687  30 NEDDEEIQEVAEKAMEQVNDQTRYRNlYKLVRVISAQTQVVAGIKYYLTILAAPTTCRKGAVGMNPMKCTIDSSKPTKQF 109
Cdd:cd00042   7 PANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCPDCKLLEEGKKKFC 85

                        90
                ....*....|....*.
gi 74834687 110 KIEVWSAPWQNTFKVT 125
Cdd:cd00042  86 TAKVWEKPWENFKELL 101
 
Name Accession Description Interval E-value
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 30-125 4.28e-31

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 106.79  E-value: 4.28e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74834687  30 NEDDEEIQEVAEKAMEQVNDQTRYRNlYKLVRVISAQTQVVAGIKYYLTILAAPTTCRKGAVGMNPMKCTIDSSKPTKQF 109
Cdd:cd00042   7 PANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCPDCKLLEEGKKKFC 85

                        90
                ....*....|....*.
gi 74834687 110 KIEVWSAPWQNTFKVT 125
Cdd:cd00042  86 TAKVWEKPWENFKELL 101
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 30-125 6.27e-27

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 95.96  E-value: 6.27e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74834687     30 NEDDEEIQEVAEKAMEQVNDQTRyrNLYKL--VRVISAQTQVVAGIKYYLTILAAPTTCRKGAVgmNPMKCTIDSSKPtK 107
Cdd:smart00043  10 PPNDPEVQEAADFAVAEYNKKSN--DKYELrvIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSV--DLENCPFLDQGE-K 84

                           90
                   ....*....|....*...
gi 74834687    108 QFKIEVWSAPWQNTFKVT 125
Cdd:smart00043  85 FCTAKVWEKPWENKIKLV 102
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 30-118 6.90e-15

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 65.05  E-value: 6.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74834687    30 NEDDEEIQEVAEKAMEQVNDQTRyRNLYKLVRVISAQTQVVAGIKYYLTILAAPTTCRKgaVGMNPMKCTIDSSKPTKQF 109
Cdd:pfam00031   7 PDNSPELQEALDFALAEYNAKTD-NYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSK--SKKLLEDCPLLDEKWLGLC 83


                  ....*....
gi 74834687   110 KIEVWSAPW 118
Cdd:pfam00031  84 SAQVYKVPW 92
 
Name Accession Description Interval E-value
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 30-125 4.28e-31

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 106.79  E-value: 4.28e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74834687  30 NEDDEEIQEVAEKAMEQVNDQTRYRNlYKLVRVISAQTQVVAGIKYYLTILAAPTTCRKGAVGMNPMKCTIDSSKPTKQF 109
Cdd:cd00042   7 PANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCPDCKLLEEGKKKFC 85

                        90
                ....*....|....*.
gi 74834687 110 KIEVWSAPWQNTFKVT 125
Cdd:cd00042  86 TAKVWEKPWENFKELL 101
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 30-125 6.27e-27

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 95.96  E-value: 6.27e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74834687     30 NEDDEEIQEVAEKAMEQVNDQTRyrNLYKL--VRVISAQTQVVAGIKYYLTILAAPTTCRKGAVgmNPMKCTIDSSKPtK 107
Cdd:smart00043  10 PPNDPEVQEAADFAVAEYNKKSN--DKYELrvIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSV--DLENCPFLDQGE-K 84

                           90
                   ....*....|....*...
gi 74834687    108 QFKIEVWSAPWQNTFKVT 125
Cdd:smart00043  85 FCTAKVWEKPWENKIKLV 102
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 30-118 6.90e-15

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 65.05  E-value: 6.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74834687    30 NEDDEEIQEVAEKAMEQVNDQTRyRNLYKLVRVISAQTQVVAGIKYYLTILAAPTTCRKgaVGMNPMKCTIDSSKPTKQF 109
Cdd:pfam00031   7 PDNSPELQEALDFALAEYNAKTD-NYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSK--SKKLLEDCPLLDEKWLGLC 83


                  ....*....
gi 74834687   110 KIEVWSAPW 118
Cdd:pfam00031  84 SAQVYKVPW 92
SQAPI pfam16845
Aspartic acid proteinase inhibitor; SQAPI, aspartic acid inhibitor first isolated from squash, ...
 30-125 1.51e-09

Aspartic acid proteinase inhibitor; SQAPI, aspartic acid inhibitor first isolated from squash, inhibits a wide range of aspartic proteinases. This particular family of PAAPIs (proteinaceous aspartic acid inhibitors) seems to have evolved quite recently from an ancestral cystatin. Structurally it consists of a four-stranded anti-parallel beta-sheet gripping an alpha-helix in much the same manner that a hand grips a tennis racket. The unstructured N-terminus and the loop connecting beta-strands 1 and 2 are important for pepsin inhibition, but the loop connecting strands 3 and 4 is not.


Pssm-ID: 407092  Cd Length: 83  Bit Score: 50.89  E-value: 1.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74834687    30 NEDDEEIQEVAEKAMEQVNDQTRyRNLyKLVRVISAQTQVVAGIKYYLTILAApttcrkgavgmnpmkctiDSSKPTKQF 109
Cdd:pfam16845   3 DVSDPHVVEIAKFAVSEHNKQSK-ANL-VFVKVVKGETQVVSGTNYRLVIAAK------------------DGGGATKNY 62

                          90
                  ....*....|....*.
gi 74834687   110 KIEVWSAPWQNTFKVT 125
Cdd:pfam16845  63 EAVVWEKPWEHFRSLT 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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