|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
11-374 |
1.77e-120 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 353.93 E-value: 1.77e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 11 FYTIWAGQAVSLITSAILQMAIIFYLTEKTGSAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSV 90
Cdd:TIGR00900 1 FRLLFAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLVAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 91 LTIVAFYMELPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAI 170
Cdd:TIGR00900 81 LPFVALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 171 IAIDVLGAVIASITVAIVRIPKLGD-RVQSLDPNFIREMQEGMAVLRQNKGLFALLLVGTLYMFVYMPIN-ALFPLISMD 248
Cdd:TIGR00900 161 IWVDAVGFAISALLIVSVRIPELAAsEIQALSNAVLRDTREGIKFVLKNPLLRTLLLLALLFNLVFAPAIvALFPYVQSK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 249 YFNGTPVHISITEISFASGMLIGGLLLGLFGNYQKRILLITASIFMMGISLTISGLLPqSGFFIFVVCCAIMGLSVPFYS 328
Cdd:TIGR00900 241 YLGRGSTHYGWVLAAFGLGALLGALLLGLLGRYFKRMALMTGAIFVIGLAILVVGLTP-PNFPLFLVLWFAIGVGYGPIN 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 75427848 329 GVQTALFQEKIKPEYLGRVFSLTGSIMSLAMPIGLILSALFADRIG 374
Cdd:TIGR00900 320 VPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILAGPLADHLG 365
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
11-396 |
6.75e-69 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 222.49 E-value: 6.75e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 11 FYTIWAGQAVSLITSAILQMAIIFYLTEKTGSAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSV 90
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 91 LTIVAFYMELPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAI 170
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 171 IAIDVLGAVIASITVAIVRIPKLGDRVQSLDPNfIREMQEGMAVLRQNKGLFALLLVGTLYMFVYMPINALFPLISMDYF 250
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLL-LRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 251 NGTPVHISITEISFASGMLIGGLLLGLFGNYQKRILLITASIFMMGISLTISGLLPQsgFFIFVVCCAIMGLSVPFYSGV 330
Cdd:cd06173 240 GGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPS--LWLLLAALFLLGLAGGLFNVP 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 75427848 331 QTALFQEKIKPEYLGRVFSLTGSIMSLAMPIGLILSALFADRIGVNHWFLLSGTLIICIAIVCPMI 396
Cdd:cd06173 318 LNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
14-393 |
3.28e-25 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 105.59 E-value: 3.28e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 14 IWAGQAVSLITSAILQMAIIFYLTEKTGSAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSVLTI 93
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 94 VAfymelPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYS--VWELNAII 171
Cdd:cd06174 81 AP-----SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 172 AIDVLGAVIASITVAIVRIPKLGDRVQSLDPNFIREMQEGMAVLRQNKGLFALLLVGTLYMFVYMPINALFPLISMDYFN 251
Cdd:cd06174 156 LIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 252 GTP-VHISITEISFASGMLIGGLLLGLFGNYQKRILLITASIFMMGISLTISGLLPQsgFFIFVVCCAIMGLSVPFYSGV 330
Cdd:cd06174 236 LSVaVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPS--LLLLLLLLLLLGFGLGGLLPL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 75427848 331 QTALFQEKIKPEYLGRVFSLTGSIMSLAMPIG-LILSALFADRIGVNHWFLLSGTLIICIAIVC 393
Cdd:cd06174 314 SFALIAELFPPEIRGTAFGLLNTFGFLGGAIGpLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-361 |
1.87e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 94.66 E-value: 1.87e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 11 FYTIWAGQAVSLITSAILQMAIIFYLTEKTGSAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGAdLIIAAAGSV 90
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG-LLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 91 LTIVAfymeLPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAI 170
Cdd:COG2814 91 LCALA----PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 171 IAIDVLGAVIASITVAIVripklgdrVQSLDPNFIREMQEGMAVLRQNKGLFALLLVGTLYMFVYMPINALFPLISMDYF 250
Cdd:COG2814 167 FLVNAVLALLALLLLLRL--------LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 251 NGTPVHISITEISFASGMLIGGLLLGLFGNYQKRILLITASIFMMGISLTISGLLPqsGFFIFVVCCAIMGLSVPFYSGV 330
Cdd:COG2814 239 GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG--SLWLLLLALFLLGFGFGLLFPL 316
|
330 340 350
....*....|....*....|....*....|.
gi 75427848 331 QTALFQEKIKPEYLGRVFSLTGSIMSLAMPI 361
Cdd:COG2814 317 LQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-392 |
1.58e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 92.25 E-value: 1.58e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 19 AVSLITSAILQMAII----FYLTEKTGSAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSVLTIV 94
Cdd:cd17325 2 SLALFLDMLGYGIIIpilpLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 95 AFYmelpvWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAIIAid 174
Cdd:cd17325 82 TSY-----WQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFL-- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 175 VLGAVIASITVAIVRIPKLGDRVQSLDPNFIREMQEGMAVLRQNKGLFALLLVGTLYMFVYMPINALFPLISMDYFNGTP 254
Cdd:cd17325 155 VCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 255 VHISITEISFASGMLIGGLLLGLFGNYQKRILLITASIFMMGISLTISGLLPqsGFFIFVVCCAIMGLSVPFYSGVQTAL 334
Cdd:cd17325 235 AQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT--SFWLLLLLLALLGLGLGLVFPATLAL 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 75427848 335 FQEKIKPEYLGRVFSLTGSIMSLAMPIGLILSALFADRIGVNHWFLLSGTLIICIAIV 392
Cdd:cd17325 313 LADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVL 370
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-362 |
7.54e-17 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 80.93 E-value: 7.54e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 14 IWAGQAVSLITSAILQMAIIFYLTEKTG-SAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSVLT 92
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 93 IVAfymelPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAIIA 172
Cdd:pfam07690 81 FAS-----SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 173 IDVLGAVIASITVAIVRIPKLGDRVQSLDPNFIREMQEGMAVLRQNkgLFALLLVGTLYMFVYMPINALFPLISMDYFNG 252
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDP--VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 253 TPVHISITEISFASGMLIGGLLLGLFGNYQKRILLITASIFMMGISLTISGLLPQSGFFIFVVCCAIMGLSVPFYSGVQT 332
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALN 313
|
330 340 350
....*....|....*....|....*....|
gi 75427848 333 ALFQEKIKPEYLGRVFSLTGSIMSLAMPIG 362
Cdd:pfam07690 314 ALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
11-254 |
1.17e-15 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 78.64 E-value: 1.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 11 FYTIWAGQAVSLITSAILQMAIIFYLTEKTGSAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSV 90
Cdd:pfam05977 12 FRVIWIASLASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVSTL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 91 LTIVAFYMELPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAI 170
Cdd:pfam05977 92 LTLLAGLGLLSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGPAFT 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 171 IAIDVLGAViaSITVAIVRIPKLGDRVQSLDPNFIREMQEGMAVLRQNKGLFALLLVGTLYMFVYMPINALFPLISMDYF 250
Cdd:pfam05977 172 FALNALSYF--AVIAALWRWKRAAPASPLPRERIFGAVRAGLRFTAMSRELRSVLVRAFAFGLSASAVWALLPLVARDLL 249
|
....
gi 75427848 251 NGTP 254
Cdd:pfam05977 250 DGDA 253
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
8-370 |
1.22e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 63.00 E-value: 1.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 8 KLKFYTIWA---GQAVSLITSAILQMAIIFYLTEKTG-SAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKK------IM 77
Cdd:COG2211 6 KLSLKEKLAyglGDLGLNLAFGLLSAYLLYFYTDVLGlSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwIL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 78 IGAdlIIAAAGSVL--TIVAFYMELPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPE-EQLTKCAGYSQSLQSISYIVS 154
Cdd:COG2211 86 IGA--IPLALSFVLlfTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAGLGGLLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 155 PAVAALLYSVWELNAIIAIDVLGAVIASITVAIVRIPKLGDRVQSLDPNFIREMQEGMAVLRQNKGLFALLLVGTLYMFV 234
Cdd:COG2211 164 SVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 235 YMPINALFPLISMDYFNGTPVHISITEISFASGMLIGGLLLGLFGNYQKRILLITASIFMMGISLTISGLLPQSGFFIFV 314
Cdd:COG2211 244 LALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLL 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 75427848 315 VCCAIMGLSVPFYSGVQTALFQEKIKPEYL---GRVFSLTGSIMSLAMPIGLILSALFA 370
Cdd:COG2211 324 VLAALAGIGLGAILVLPWAMLADVVDYDEWktgRRREGLYFGIFTFAIKLGQALAGALA 382
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
54-392 |
1.75e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.20 E-value: 1.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 54 FLPYAVFGPAIGVLVDRHDRKKIMIGAdLIIAAAGSVLTIVAfymeLPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPE 133
Cdd:cd17474 44 TLPAAVLMPVAGVLADRFGRKKVLLPG-LLLFGIGGLLCGLS----DSFALLLAGRALQGIGAAGLGPLALTLIGDLFEG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 134 EQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAIIAIDVLGAVIASITVAIVRIPKlgDRVQSLDPNFIRemqeGMA 213
Cdd:cd17474 119 GERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPK--EKAKSSSATKLR----DLK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 214 VLRQNKGLFALLLVGTLYMFVYMPINALFPLISMDYFNGTPVHIS--ITEISFASGMLIGGLLLGLFGNYQKRILLITAS 291
Cdd:cd17474 193 KALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGllFAGWSVLLALGSLFVGRLLKKRFGARRILVIGL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 292 IFmMGISLTISGLLPQSGFFIfvVCCAIMGLSVPFYSGVQTALFQEKIKPEYLGRVFSLTGSIMSLAMPIGLILSALFAD 371
Cdd:cd17474 273 LL-YALSLLLLGFVPSLALLL--IAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLE 349
|
330 340
....*....|....*....|.
gi 75427848 372 RIGvNHWFLLSGTLIICIAIV 392
Cdd:cd17474 350 IFG-LSAPFLVGAAIALAAAV 369
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
42-401 |
8.82e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 59.88 E-value: 8.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 42 SAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGAdLIIAAAGSVLTIVAFymelPVWMVMIVLFIRSIGTAFHTP 121
Cdd:COG2271 43 SAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG-LLLWGLATLLFGFAT----SFWQLLLLRFLLGLGEAGFFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 122 ALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAIIAIdvlgAVIASITVAIVRIpklgdrvqsld 201
Cdd:COG2271 118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI----LGLPGLLLALLRF----------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 202 pnfiremqegmavlrqnkglFALLLVGTLYMFVYMPINALFPLISMDYFNGTPVHISITEISFASGMLIGGLLLGLFGNY 281
Cdd:COG2271 183 --------------------WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 282 QKRILLITASIFMMGISLTISGLLPQSGFFIFVVCCAIMGLSVPFYSGVQTALFQEKIKPEYLGRVFSLTGSIMSLAMPI 361
Cdd:COG2271 243 LGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGAL 322
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 75427848 362 GLILSALFADRIGVNHWFL-LSGTLIICIAIVCPMINEIRK 401
Cdd:COG2271 323 GPLLVGYLLDATGYQAAFLlLAALALLAALLALLLLRETRK 363
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
32-393 |
1.75e-09 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 59.94 E-value: 1.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 32 IIFYLTEKTGSAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIiAAAGSVLTIVAFYMELPvWMVMIVLFI 111
Cdd:PRK08633 35 TLIKAYDGSEQVILTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVKLF-EVGLTLLIVLAYYLGWF-WLAFAVTFL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 112 RSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELN--------------AIIAIDVLG 177
Cdd:PRK08633 113 LGAQSAIYSPAKYGIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFESVNGNtpseilgriapaglVLLAVAVLG 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 178 AVIASitvaivRIPKL-------GDRVQSLDPNFIRemqEGMAVLRQNKGLFaLLLVG-TLYMFVYMPINALFPLISMDY 249
Cdd:PRK08633 193 LIFAY------RLPKVpaaapevFDKKKYLFPKLLW---RNLKLLRSDRVLW-LAIIGlSYFWFISQLAQANFPAYAKEV 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 250 FNGTPVHISitEISFASGMLIGGLLLGLFGNYQKR----------ILLITASIFMMGISLTISGLLpqSGFFIFVVCCAI 319
Cdd:PRK08633 263 LGLDNTFQV--QYLLAASAIGIGIGSLLAGRLSGRhielglvplgALGLALSLFLLPTAPSLASVL--VLFFLFGFSAGL 338
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 75427848 320 mgLSVPFYsgvqtALFQEKIKPEYLGRVFSLTGSIMSLAMPIGLILSALFAdrigvnhWFLLSGT-LIICIAIVC 393
Cdd:PRK08633 339 --FIVPLN-----ALIQFRAPEKELGKVLAANNFLQNVGMLLFLALTTLFS-------GLGLSPAgLFYLIALVT 399
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
21-392 |
4.74e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 57.62 E-value: 4.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 21 SLITSAILQMAIIFYLTEKTGSAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSVLTIVAfymel 100
Cdd:cd17329 12 RLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAH----- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 101 PVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAIIAIDVLGAVI 180
Cdd:cd17329 87 SPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 181 ASITVAIVRIPKLGDRVQSLDPNFiremqEGMAVLRQNKGLFALLLVGTLYMFVYMPINALFPLISMDYFNGTPVHISIT 260
Cdd:cd17329 167 ALVLLFLLPETRPKRRAAEKTEIL-----RGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 261 EISFASGMLIGGLLLGLFGNYQKRILLITASIFMMGISLTISGLLPQsgFFIFVVCCAIMGLSVPFYSGVQTALFQEKIK 340
Cdd:cd17329 242 LALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANT--LAVLILAMIVLTLGEMLVFPAVQTLVAALAP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 75427848 341 PEYLGRVFSLTGSIMSLAMPIGLILSALFADRIGVNH-WFLLSGTLIICIAIV 392
Cdd:cd17329 320 PDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLpWLILAALGLIAAALL 372
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-189 |
9.99e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 56.43 E-value: 9.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 19 AVSLITSAILQMAIIFYLTEKTG-SAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSVLTIVAFY 97
Cdd:cd17325 209 FVLAFAFGALEPFLPLYAAELGGlSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 98 melpvWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAIIAIDVLG 177
Cdd:cd17325 289 -----WLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAAL 363
|
170
....*....|..
gi 75427848 178 AVIASITVAIVR 189
Cdd:cd17325 364 LLLAAVLFLLLR 375
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
46-401 |
4.98e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 51.39 E-value: 4.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 46 LSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSVLTIVAFYmelpvWMVMIVLFIRSIGTAFHTPALNA 125
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY-----PLLLLALFLLGLGLGLLDVAANP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 126 VTPLLVPEEQLTKCAGySQSLQSISYIVSPAV-AALLYSVWELNAIIAIDVLGAVIASITVAIVRIPKlgdRVQSLDPNF 204
Cdd:COG0738 120 YVAALGPETAASRLNL-LHAFFSLGALLGPLLgGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKL---PEIEEEEEE 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 205 IREMQEGMAVLRQNKGLFALLLVGTLYMFVYMPINALFPLISMDYFNGTPVHISITEISFASGMLIGGLLLGLFGNYQKR 284
Cdd:COG0738 196 AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGP 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 285 ILLITASIFMMGISLTISGLLPqsGFFIFVVCCAIMGLSV-PFYSGVQTALFqeKIKPEYLGRVFSLTGSIMSLAMPIGL 363
Cdd:COG0738 276 VRLLRLSALLAAVGLLLALLAP--GPWLALIGLALVGLGLsLMFPTIFSLAL--DGLGKRTAAAVSAVLIMGIVGGAIGP 351
|
330 340 350
....*....|....*....|....*....|....*...
gi 75427848 364 ILSALFADRIGVNHWFLLSGTLIICIAIVCPMINEIRK 401
Cdd:COG0738 352 PLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRR 389
|
|
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
28-254 |
8.18e-07 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 51.50 E-value: 8.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 28 LQMAIIFYLTEKTG--SAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIM--IGADLIIAAAgsvLTIVAFYMElPVW 103
Cdd:PRK06814 34 LVILILYGLSGALGayNNALVTLAGAVFILPFFIFSALAGQLADKYDKAKLAkiLKFAEIGIAA---LAIYGFHLN-SVP 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 104 MVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISyIVSPAVAALLYSVWELNAIIAIDVLGAVIASI 183
Cdd:PRK06814 110 LLFAALFLMGIHSALFGPIKYSILPDHLNKDELLGANALVEAGTFIA-ILLGTIIGGLATISGNFVILVALLMGIAVLGW 188
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75427848 184 TVAIvRIPKLGDRVQSL--DPNFIREMQEGMAVLRQNKGLFALLLVGTLYMFVYMPINALFPLISMDYFNGTP 254
Cdd:PRK06814 189 LASL-FIPKTGNAAPDLkiDRNIIRSTITLLKYAKADKRIWLAILGISWFWLVGAVVLSQLPLLAKETLGGDE 260
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
14-247 |
1.62e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 49.42 E-value: 1.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 14 IWAGQAVSLITSAILQMAIIFYLTEKTGSAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIgADLIIAAAGSVLTI 93
Cdd:COG0477 19 LALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL-IGLLLFGLASLLCG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 94 VAFymelPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAIIAI 173
Cdd:COG0477 98 LAP----SPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI 173
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 75427848 174 DVLGAVIASITVAIVRIPKLGDRVQSLDPNFIREMQEGMAVLRQNKGLFALLLVGTLYMFVYMPINALFPLISM 247
Cdd:COG0477 174 NAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLL 247
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
11-350 |
2.21e-06 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 49.59 E-value: 2.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 11 FYTIWAGQAVSLITSAILQMAIIFYLTEKTGSAMVLSMASLLgfLPYAVFGPAI--GVLVDRHDRKKIMIGADLIIAAAG 88
Cdd:PRK10489 19 FRAVFIARFISIFGLGLLGVAVPVQIQMMTGSTLQVGLSVTL--TGGAMFIGLMvgGVLADRYDRKKLILLARGTCGLGF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 89 SVLTIVAFYMELPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELN 168
Cdd:PRK10489 97 IGLALNAFLPEPSLLAIYLLGLWDGFFGSLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPALGGLLIAAGGVA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 169 AIIAIDVLGAVIASITvaIVRIPKLGDRVQSLDPNFiREMQEGMAVLRQNKGLFALLLVGTLYMFVyMPINALFPLISMD 248
Cdd:PRK10489 177 WNYGLAAAGTFITLLP--LLRLPALPPPPQPREHPL-RSLLAGFRFLLASPVVGGIALLGGLLTMA-SAVRVLYPALADE 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 249 YFNGTPVHISI--TEISFASGMLIGGLLLGLFGNYQKRILLITAsifmMGISLTISGLLPQSGFFIFVVCCAIMGLSVPF 326
Cdd:PRK10489 253 VWQMGAAQIGLlyAAVPLGAALGALTSGWLAHSARPGLLMLLST----LGSFLAVGLFGLMPMWILAVLCLALFGYLSAI 328
|
330 340
....*....|....*....|....
gi 75427848 327 YSGVQTALFQEKIKPEYLGRVFSL 350
Cdd:PRK10489 329 SSLLQYTLLQTQTPDEMLGRINGL 352
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
47-236 |
7.24e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 47.62 E-value: 7.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 47 SMASLLGF---LPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSVLTIVAFYmelpvWMVMIVLFIRSIGTAFHTPAL 123
Cdd:cd17328 34 SLAGLLQTvfiISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNF-----WQLLLFRALVGIGEASYSPIA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 124 NAVTPLLVPEEQLTKCAGY---SQSLQS-ISYIVSPAVAALLYSvWELnAIIAIDVLGAVIASITVAIVRIPKLGDRVQS 199
Cdd:cd17328 109 PTIIADLFPKEKRTRALGVfyfAIPLGSgLGYVVGGLVAQATGG-WRW-AFRVTGVLGVLLAILLLLFVREPPRGAAEGG 186
|
170 180 190
....*....|....*....|....*....|....*...
gi 75427848 200 -LDPNFIREMQEGMAVLRQNKGLFALLLVGTLYMFVYM 236
Cdd:cd17328 187 vMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTG 224
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
35-392 |
1.32e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.82 E-value: 1.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 35 YLTEKTGSAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSVLTIVAfymelPVWMVMIVLFIRSI 114
Cdd:cd17489 22 YAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT-----SVALLLVLRLIHGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 115 GTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAIIAIDVLGAVIASITVAIVRIPKL- 193
Cdd:cd17489 97 GWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPv 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 194 ---GDRVQSLDPNFIREMqegmavlrqnkglfALLLVGTLYMFVYMPINALFPLISMDYFNGTPVHISITEISFASGMLI 270
Cdd:cd17489 177 aaeEAEAGTRAFRRLVEK--------------KVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYAIALLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 271 GGLLLGLFGNYQKRILLITASIFMMGISLTIsgLLPQSGFFIFVVCCAIMGLSVPFYSGVQTALFQEKIKPEYLGRVFSL 350
Cdd:cd17489 243 SRPFSGKLSDRKGPKTVIIPGLLLLALGLLL--LSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGT 320
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 75427848 351 TGSIMSLAMPIGLILSALFADRIGVNHWFLLSGTLIICIAIV 392
Cdd:cd17489 321 FFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-191 |
1.89e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.40 E-value: 1.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 9 LKFYTIWAGQAVSLITSAILQMAIIFYLTEKTG-SAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIgadLIIAAA 87
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGlSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLV---LAIGLL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 88 GSVLTIVAFYMELPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWEL 167
Cdd:COG2271 257 LAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGY 336
|
170 180
....*....|....*....|....
gi 75427848 168 NAIIAIDVLGAVIASITVAIVRIP 191
Cdd:COG2271 337 QAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
34-392 |
2.12e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 46.03 E-value: 2.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 34 FYLTEKTGSAMVLSMASLLG---FLPYAVFGPAIGVLVDRHDRKKImigadLIIAAAGSVLTIVAFYMELPVWMVMIVLF 110
Cdd:cd17330 21 FYVREFNKLGASGYYVGLLQssySLGQFLASPLWGRLSDRYGRKPV-----LLLSLAGSAVSYVLLGLSRNLWLLFLARF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 111 IRSIGTAfHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAIIAIDVLGAVIAsiTVAIVRI 190
Cdd:cd17330 96 LDGLTGG-NVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLN--LVLVLFF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 191 PKLgdrvqsldpnfiremqegmavlrqnkgLFALLLVGTLYMFVYMPINALFPLISMDYFNGTPVHISIT--EISFASGM 268
Cdd:cd17330 173 LPP---------------------------LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLlaLVGIAGIL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 269 LIGGLLLGLFGNYQKRILLITASIFMMgisLTISGLLPQSGFFIFVVCCAIMGLSVPFYSGVQTALFQEKIKPEYLGRVF 348
Cdd:cd17330 226 AQLLLIPRLAKRLGERKLLRLGLLLAI---IGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQ 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 75427848 349 SLTGSIMSLAMPIGLILSALFADRIGVNHWFLLSGTLIICIAIV 392
Cdd:cd17330 303 GIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFL 346
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
19-183 |
7.04e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.46 E-value: 7.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 19 AVSLITSAILQMAIIFYLTEKTGSAMVLSMASLLGF-LPYAVFGPAIGVLVDRHDRKKIMIGAdLIIAAAGSVLtivaFY 97
Cdd:cd17370 208 AVALFALGNFSFAFLILRAQELGLSAALIPLLYALFnLVYALAAYPAGRLSDRIGRKKLLILG-YLSLALAYLG----FA 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 98 MELPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAIIAIDVLG 177
Cdd:cd17370 283 LGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVL 362
|
....*.
gi 75427848 178 AVIASI 183
Cdd:cd17370 363 ALIALL 368
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
13-163 |
3.01e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.55 E-value: 3.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 13 TIWAGQAVSLITSAILqMAIIFYLTE-----KTGSAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGAdLIIAAA 87
Cdd:cd17321 169 TFSGAVLAAFLLGAAL-GGLLFLLPLylqgvLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAG-LLLTAV 246
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 75427848 88 GSVLTIVAFYMeLPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYS 163
Cdd:cd17321 247 GLLLLALLGAD-SSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLT 321
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
42-401 |
4.00e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 42.18 E-value: 4.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 42 SAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGAdLIIAAAGSVLTIVAfymeLPVWMVMIVLFIRSIGTAFHTP 121
Cdd:COG2223 38 SAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIG-LLLLGIGLLLLALA----VSYWLLLLLGLLLGIGGGGSFA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 122 ALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWEL-NAIIAIDVLGAVIASITVAIVRIPKLGDRVQSL 200
Cdd:COG2223 113 VGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWrNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 201 DPnfireMQEGMAVLRqNKGLFALLLVGTLYMFVYMPINALFPLISMDYFNGTPVHISITEISFASGMLIGGLLLGLFGN 280
Cdd:COG2223 193 AS-----LRDQLEALR-DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSD 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 281 YQKRILLITASIFMMGISLTISGLLPQSgFFIFVVCCAIMGLSVPFYSGVQTALFQEKIKPEYLGRVFSLTGSIMSLAMP 360
Cdd:COG2223 267 RIGGRRVLLIVFALMALGLLLLALALGS-LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGF 345
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 75427848 361 IGLILSALFADRIGVNH--WFLLSGTLIICIAIVCPMINEIRK 401
Cdd:COG2223 346 LGPLLFGALLDATGSYTaaFLVFAVLALVALVLTLLLYRRPRR 388
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
22-165 |
8.59e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.02 E-value: 8.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 22 LITSAILQMAIIFYLTEKT----GSAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSVLTIVAFy 97
Cdd:cd17330 185 LIALAFAGLESVFSLFLKDrfgfSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASS- 263
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 75427848 98 melpVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVW 165
Cdd:cd17330 264 ----VPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFL 327
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
55-393 |
8.81e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.00 E-value: 8.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 55 LPYAVFGPAIGVLVDRHDRKKIMIGAdLIIAAAGSVLTIVAFymelPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEE 134
Cdd:cd17324 45 LGYALGALLLGPLSDRIERRRLLLVL-LLLFILGNLLAALAP----SFALLLLARALAGLAHGGFWAIAAAYAADLVPPE 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 135 QLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAIIAIDVLGAVIASITVAIVrIPKLGDRVQSLDPNFIREmqegMAV 214
Cdd:cd17324 120 KRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRL-LPSLPPKKPGSLGLLSSL----LLL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 215 LRQNKGLFALLLVGTLYMFVYMPINAL-FPLISMDYFNGTPVHISITEISFASGMLIGGLLLGLFGNYQKRILLITASIF 293
Cdd:cd17324 195 LRNPRLRLAYLITFLLFGGFFALYTYLaPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLA 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 294 MMGISLTISGLLPQSGFFIFVVCCAIMGLSVPfysGVQTALFQekIKPEYLGRVFSLTGSIMSLAMPIGLILSALFADRI 373
Cdd:cd17324 275 AALLLLTLLGPSPLLLLVGLVLWGLGFFAAHS---ALQTRVLR--LAPEARGLASSLYLAAYNLGGALGAALGGLVLDHG 349
|
330 340
....*....|....*....|
gi 75427848 374 GVNHWFLLSGTLIICIAIVC 393
Cdd:cd17324 350 GWAGVGWVGAALLLLALLLA 369
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
216-392 |
1.54e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.34 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 216 RQNKGLFALLLVGTLYMFVYMPINALFPLIsMDYFNGTPVHISITEISFASGMLIGGLLLGLFGNYQKRILLITASIFMM 295
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLI-AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 296 GISLTISGLLPqsGFFIFVVCCAIMGLSVPFYSGVQTALFQEKIKPEYLGRVFSLTGSIMSLAMPIGLILSALFADRIGV 375
Cdd:COG2814 86 ALGSLLCALAP--SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170
....*....|....*..
gi 75427848 376 NHWFLLSGTLIICIAIV 392
Cdd:COG2814 164 RWVFLVNAVLALLALLL 180
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
58-392 |
1.68e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 40.28 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 58 AVFGPAIGVLVDRHDRKKIMIGAdLIIAAAGSVLTIVAfymeLPVWMVMIVLFIRSIGtAFHTPALNAVTPlLVPEEQLT 137
Cdd:cd17472 46 AIFQIPFGLLSDRIGRKPVILFG-LLLFIAGSLLAAYA----TSIYGLILGRALQGSG-AISSVVMALLAD-LTREENRT 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 138 KCAGYSQSLQSISYIVSPAVAALLYSVWELNAIIAIDVLGAVIASITVAIVRI-PKLGDRVQSLDPNFIREmqegmavLR 216
Cdd:cd17472 119 KAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPdPPKIVQISEKEKKKLKK-------LL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 217 QNKGLFALLLVGTLYMFVYMPINALFPLISMDYFNGTPVHISITEISFASGMLIGGLLLGLFGNYQKRILLITASIFMMG 296
Cdd:cd17472 192 KNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSSILLIA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 297 ISLTISGLLPQSGFFIFVvccaimgLSVPFYSG--VQTALFQEKI----KPEYLGRVFSLTGSIMSLAMPIGLILSALFA 370
Cdd:cd17472 272 VGFLLLLFAATSLWLLII-------GLIIFFIGfnLLEALLPSLVskiaPKEYRGTAMGIYNTSQFLGSFLGGALGGLLW 344
|
330 340
....*....|....*....|..
gi 75427848 371 DRIGVNHWFLLSGTLIICIAIV 392
Cdd:cd17472 345 GLLGYSSVFLTILILALLWLLV 366
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
31-253 |
1.76e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.23 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 31 AIIFYLTEKTG-SAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSVLTIVAFYmelpvWMVMIVL 109
Cdd:cd17478 17 ALLPLLIAKLGlSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNY-----WLLLLLV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 110 FIRSIGTA-FHTPALNAVTplLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAIIAIDVLGAVIASITVAIV 188
Cdd:cd17478 92 ALAGIGSAaFHPEGARLAS--QAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRL 169
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 75427848 189 RIPKLGDRVQSLDPNFIREMQEGMAvlrqnKGLFALLLVGTLYMFVYMPINALFPLISMDYFNGT 253
Cdd:cd17478 170 RPLKKPEAKKAAAKSSARSTLKGVW-----RALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSL 229
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
19-392 |
4.00e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 39.09 E-value: 4.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 19 AVSLITSAILQMAIIFYLTEKTGSAMVLSMASLLgflpYAVFGPAIGVLVDRHDRKKIMIGADLIIAAAGsvltIVAFYM 98
Cdd:cd17473 14 AGAAIAPALPAIAQHFVPNSELLVPLLLTLPALF----IALFAPLAGWLADRFGRKRLLIAGLLLYGIGG----VAGLFL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 99 ElPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSV-WelNAIIAIDVLG 177
Cdd:cd17473 86 D-SLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIgW--RAPFLVYLLA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 178 AVIASITVAIVRIPKLGDRVQSldpnfirEMQEGMAVLRQNKGLFALLLVGTLYMFVYMPINALFPLISMDYFNGTPVHI 257
Cdd:cd17473 163 LPVLILVLLFLPEPARKSKSAA-------SPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 258 SITeISFASGMLIGG-LLLGLFGNYQKRILLITASIFMMGISLTISGLLPqsGFFIFVVCCAIMGLSVPFYSGVQTALFQ 336
Cdd:cd17473 236 GLA-LAIASLAGAIGaLLFGRLKRRLGKRRLLAIGFALMALGFLLLALAS--GLWVVLLGAILAGLGFGLLLPTLNSWAM 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 75427848 337 EKIKPEYLGRVFsltgSIMSLAMPIGLILSAL---FADRIGVNHW--FLLSGTLIICIAIV 392
Cdd:cd17473 313 SLVPPELRGRAM----GIVTSAFFLGQFLSPLvlgPLVNLTGGLSgaFLILGVLALVLAIV 369
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
15-138 |
4.05e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 38.98 E-value: 4.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 15 WAGQAVS-LITSAIlqMAIifYLTEKTG------SAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAAA 87
Cdd:COG2270 20 WANSAFStVITTFV--FPP--YFTSVAAlgdpaaATALWGYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFFTLLGVL 95
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 75427848 88 GSVLtiVAFYMELPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTK 138
Cdd:COG2270 96 ATAA--LFFVAPGGLWLGLLLFVLANIGFEGSLVFYNAFLPDIATPEEIGR 144
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
7-155 |
4.77e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.94 E-value: 4.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 7 WKLKFYTIWAGQAVSLITSAILQMAIIFYLTEKTGSAMVLSMASLLGFLPYAVFGPAIGVLVDRHDRKKIMIGADLIIAA 86
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIL 277
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 75427848 87 AGSVLTIVAFYmeLPVWMVMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSP 155
Cdd:pfam07690 278 AALGLLLLSLT--LSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MFSD1 |
cd17340 |
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ... |
58-158 |
5.56e-03 |
|
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340898 [Multi-domain] Cd Length: 394 Bit Score: 38.79 E-value: 5.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75427848 58 AVFGPAIGVLVDRHDRKKIMIGADLIIAAAGSVLTIVAFYMELpVWMVMIvlfirSIGTAFHTPALNAVTPLLVPEEQLT 137
Cdd:cd17340 267 AAASPVFGFLVDKVGRNILWVLIALVITLLGHLLLAFTFVNPL-IAMVIM-----GIGYSMLACALWPMVPLVVPEHQLG 340
|
90 100
....*....|....*....|.
gi 75427848 138 KCAGYSQSLQSISYIVSPAVA 158
Cdd:cd17340 341 TAYGFMQSIQNLGLAVFPIIA 361
|
|
| |
