|
Name |
Accession |
Description |
Interval |
E-value |
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
34-636 |
1.63e-129 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 395.17 E-value: 1.63e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 34 HGLKEILANGTDEVINNF-DEGIVTLElfDDlQTVRVTDTGRGIPID-GETDGVKNYELLFRTLFASTK-----YETSeq 106
Cdd:COG0187 38 HLVWEIVDNSIDEALAGYcDRIEVTLH--AD-GSVTVEDNGRGIPVDiHPKEGKSALEVVLTVLHAGGKfdggsYKVS-- 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 107 ttTGTNGVGATVLNFTSLFFYIDSYYDGYKHTLKFENGgELVQDLTKEKiSEDRHGTVITFKLDPEVYPVVTYDKDVVRE 186
Cdd:COG0187 113 --GGLHGVGASVVNALSERLEVEVKRDGKIYRQRFERG-KPVGPLEKIG-KTDRTGTTVRFKPDPEIFETTEFDYETLAE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 187 IVRRFAIGSHKIKLIFI----HNGEEETFHYES-VEEYFEELIGSTTtspVITaPDSLY---EEDGERTQIKLTFSTTTD 258
Cdd:COG0187 189 RLRELAFLNKGLTITLTdereEEPKEETFHYEGgIKDFVEYLNEDKE---PLH-PEVIYfegEKDGIEVEVALQWNDGYS 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 259 PIQESYLNLTYLSDGGSFNDGVITGIKTFCNKYARENKLFPKGINSFTTEDIESSvsfvLVA-LSNKV---EFKNQTKls 334
Cdd:COG0187 265 ENIHSFVNNINTPEGGTHETGFRTALTRVINDYARKNGLLKEKDKNLTGDDVREG----LTAvISVKLpepQFEGQTK-- 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 335 tdKKLYRKLAQRHTTQI----LEVFQIENEKGFKKFVNHLLE--------------VQKHNTQsqkakqqlkkklsekvd 396
Cdd:COG0187 339 --TKLGNSEARGIVESVvsekLEHYLEENPAEAKKILEKAILaarareaarkarelVRRKSAL----------------- 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 397 GIGNKVANLVDC-KKHGKDSEIFIAEGQSALGSIVLARDAVYQAAYPLRGKILNCLKADYTTIFKNQIITDLIKVLGCGI 475
Cdd:COG0187 400 ESSGLPGKLADCsSKDPEESELFIVEGDSAGGSAKQGRDREFQAILPLRGKILNVEKARLDKILKNEEIRDLITALGTGI 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 476 QTDkknkdldtFNINNLRYGKIIIATDQDSDGAQIACLIITMIYRLMPKLIEEGYVYIAQTPLYEIKLEDDSmIYFYSES 555
Cdd:COG0187 480 GDD--------FDLEKLRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGHVYIAQPPLYRIKKGKKT-YYAYSDA 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 556 EKDQKINTLKG--KYTIARCKGLGELDAVTMAETAMNEETRNLIKVTVEDAENMIESLETWMGSSVDNRREYISENLyKY 633
Cdd:COG0187 551 ELDELLKELKGkkKVEIQRYKGLGEMNPEQLWETTMDPETRTLLQVTIEDAAEADEIFSLLMGDKVEPRREFIEENA-KF 629
|
...
gi 1238239316 634 VEE 636
Cdd:COG0187 630 VRN 632
|
|
| PRK05559 |
PRK05559 |
DNA topoisomerase IV subunit B; Reviewed |
27-630 |
1.86e-125 |
|
DNA topoisomerase IV subunit B; Reviewed
Pssm-ID: 235501 [Multi-domain] Cd Length: 631 Bit Score: 384.45 E-value: 1.86e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 27 GSAD--NYYHGLKEILANGTDEVINNFDEGI-VTLElfDDlQTVRVTDTGRGIPIDGETD-GVKNYELLFRTLFASTKYE 102
Cdd:PRK05559 31 GSTDtrGLHHLVQEVIDNSVDEALAGHGKRIeVTLH--AD-GSVSVRDNGRGIPVGIHPEeGKSGVEVILTKLHAGGKFS 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 103 T-SEQTTTGTNGVGATVLNFTSLFFYIDSYYDGYKHTLKFEnGGELVQDLTKE-KISEDRHGTVITFKLDPEVYPVVTYD 180
Cdd:PRK05559 108 NkAYKFSGGLHGVGVSVVNALSSRLEVEVKRDGKVYRQRFE-GGDPVGPLEVVgTAGKRKTGTRVRFWPDPKIFDSPKFS 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 181 KDVVREIVRRFAI---GshkIKLIFIHNGEEETFHYES-VEEYFEELIGSTTTSPVITAPDSLYEEDGERTQIKLTFSTT 256
Cdd:PRK05559 187 PERLKERLRSKAFllpG---LTITLNDERERQTFHYENgLKDYLAELNEGKETLPEEFVGSFEGEAEGEAVEWALQWTDE 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 257 TDPIQESYLNLTYLSDGGS----FNDGVITGIKTFCNKyareNKLFPKGINsFTTEDIESSVSFVLvalSNKV---EFKN 329
Cdd:PRK05559 264 GGENIESYVNLIPTPQGGThengFREGLLKAVREFAEK----RNLLPKGKK-LEGEDVREGLAAVL---SVKIpepQFEG 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 330 QTK--LST-------DKKLYRKLAQR------HTTQILEvFQIENEKGFKKfvnhllEVQKhntqsqkakqqlkkKLSEK 394
Cdd:PRK05559 336 QTKekLGSrearrfvSGVVKDAFDLWlnqnpeLAEKLAE-KAIKAAQARLR------AAKK--------------VKRKK 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 395 VDGIGNKVANLVDCKKHGKD-SEIFIAEGQSALGSIVLARDAVYQAAYPLRGKILNCLKADYTTIFKNQIITDLIKVLGC 473
Cdd:PRK05559 395 KTSGPALPGKLADCTSQDPErTELFLVEGDSAGGSAKQARDREFQAILPLRGKILNTWEASLDDVLANEEIHDIIVAIGI 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 474 GIqtdkknkdLDTFNINNLRYGKIIIATDQDSDGAQIACLIITMIYRLMPKLIEEGYVYIAQTPLYEIKLEDDSmIYFYS 553
Cdd:PRK05559 475 GP--------GDSFDLEDLRYGKIIIMTDADVDGAHIATLLLTFFYRHFPPLVEAGHVYIALPPLYRVDKGKKK-IYALD 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 554 ESEKDQKINTL---KGKYTIARCKGLGELDAVTMAETAMNEETRNLIKVTVEDAENMIESLETWMGSSVDNRREYISENL 630
Cdd:PRK05559 546 EEEKEELLKKLgkkGGKPEIQRFKGLGEMNPDQLWETTMDPETRRLVRVTIDDAEETEKLVDMLMGKKAEPRREWIEENG 625
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
33-630 |
3.86e-116 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 359.18 E-value: 3.86e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 33 YHGLKEILANGTDEVINNF-DEGIVTLelfDDLQTVRVTDTGRGIPID-GETDGVKNYELLFRTLFASTKY-ETSEQTTT 109
Cdd:smart00433 3 HHLVDEIVDNAADEALAGYmDTIKVTI---DKDNSISVEDNGRGIPVEiHPKEKKYAPEVIFTVLHAGGKFdDDAYKVSG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 110 GTNGVGATVLNFTSLFFYIDSYYDGYKHTLKFENGGELVQDLTKEKISeDRHGTVITFKLDPEVYPVVT-YDKDVVREIV 188
Cdd:smart00433 80 GLHGVGASVVNALSTEFEVEVARDGKEYKQSFSNNGKPLSEPKIIGDT-KKDGTKVTFKPDLEIFGMTTdDDFELLKRRL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 189 RRFAIGSHKIKLIFIH--NGEEETFHYE-SVEEYFEELIGSTTTSPVITAPDSlYEEDGERTQIKLTFSTTTDPIQESYL 265
Cdd:smart00433 159 RELAFLNKGVKITLNDerSDEEKTFLFEgGIKDYVELLNKNKELLSPEPTYIE-GEKDNIRVEVAFQYTDGYSENIVSFV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 266 NLTYLSDGGSFNDGVITGIKTFCNKYARENKLFPKgiNSFTTEDI-ESSVSFVLVALSNKvEFKNQTK--LSTDKKlyRK 342
Cdd:smart00433 238 NNIATTEGGTHENGFKDALTRVINEYAKKKKKLKE--KNIKGEDVrEGLTAFISVKIPEP-QFEGQTKekLGTSEV--RF 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 343 LAQRHTTQILEVFQIENEKGFKKFVNHLLEVQKHNTQSQKAKQQLKKKLSEKVDGIGNkvanLVDC-KKHGKDSEIFIAE 421
Cdd:smart00433 313 GVEKIVSECLLSFLEENPVEASKIVEKVLLAAKARAAAKKARELTRKKKLSSISLPGK----LADAsSAGPKKCELFLVE 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 422 GQSALGSIVLARDAVYQAAYPLRGKILNCLKADYTTIFKNQIITDLIKVLGCGIQTDkknkdldtFNINNLRYGKIIIAT 501
Cdd:smart00433 389 GDSAGGSAKSGRDRDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKD--------FDIEKLRYGKIIIMT 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 502 DQDSDGAQIACLIITMIYRLMPKLIEEGYVYIAQTPLYEIKLEDDS-MIYFYSESEKDQKINTLKG---KYTIARCKGLG 577
Cdd:smart00433 461 DADVDGSHIKGLLLTFFYRYMPPLIEAGFVYIAIPPLYKVTKGKKKyVYSFYSLDEYEKWLEKTEGnksKYEIQRYKGLG 540
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|...
gi 1238239316 578 ELDAVTMAETAMNEETRNLIKVTVEDAENMIESLETWMGSSVDNRREYISENL 630
Cdd:smart00433 541 EMNADQLWETTMDPERRTLLFVTLDDADEADLIFSALMGDKVEPRKEWIEENA 593
|
|
| TOPRIM_TopoIIA_like |
cd01030 |
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
415-536 |
9.58e-46 |
|
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173780 [Multi-domain] Cd Length: 115 Bit Score: 157.67 E-value: 9.58e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 415 SEIFIAEGQSALGSIVLARDAVYQAAYPLRGKILNCLKADYTTIFKNQIITDLIKVLGCGIqtdkknkDLDTFNINNLRY 494
Cdd:cd01030 1 CELILVEGDSAGGSAKQGRDRVFQAVFPLRGKILNVEKASLKKILKNEEIQNIIKALGLGI-------GKDDFDLDKLRY 73
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1238239316 495 GKIIIATDQDSDGAQIACLIITMIYRLMPKLIEEGYVYIAQT 536
Cdd:cd01030 74 GKIIIMTDADVDGSHIRTLLLTFFYRFWPSLLENGFLYIAQT 115
|
|
| DNA_gyraseB_C |
pfam00986 |
DNA gyrase B subunit, carboxyl terminus; The amino terminus of eukaryotic and prokaryotic DNA ... |
565-626 |
9.27e-17 |
|
DNA gyrase B subunit, carboxyl terminus; The amino terminus of eukaryotic and prokaryotic DNA topoisomerase II are similar, but they have a different carboxyl terminus. The amino-terminal portion of the DNA gyrase B protein is thought to catalyze the ATP-dependent super-coiling of DNA. See pfam00204. The carboxyl-terminal end supports the complexation with the DNA gyrase A protein and the ATP-independent relaxation. This family also contains Topoisomerase IV. This is a bacterial enzyme that is closely related to DNA gyrase,.
Pssm-ID: 460016 [Multi-domain] Cd Length: 63 Bit Score: 74.72 E-value: 9.27e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1238239316 565 KGKYTIARCKGLGELDAVTMAETAMNEETRNLIKVTVEDAENMIESLETWMGSSVDNRREYI 626
Cdd:pfam00986 1 KKKVEIQRYKGLGEMNPEQLWETTMDPETRRLLQVTIEDAAEADEIFSTLMGDKVEPRREFI 62
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
34-636 |
1.63e-129 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 395.17 E-value: 1.63e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 34 HGLKEILANGTDEVINNF-DEGIVTLElfDDlQTVRVTDTGRGIPID-GETDGVKNYELLFRTLFASTK-----YETSeq 106
Cdd:COG0187 38 HLVWEIVDNSIDEALAGYcDRIEVTLH--AD-GSVTVEDNGRGIPVDiHPKEGKSALEVVLTVLHAGGKfdggsYKVS-- 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 107 ttTGTNGVGATVLNFTSLFFYIDSYYDGYKHTLKFENGgELVQDLTKEKiSEDRHGTVITFKLDPEVYPVVTYDKDVVRE 186
Cdd:COG0187 113 --GGLHGVGASVVNALSERLEVEVKRDGKIYRQRFERG-KPVGPLEKIG-KTDRTGTTVRFKPDPEIFETTEFDYETLAE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 187 IVRRFAIGSHKIKLIFI----HNGEEETFHYES-VEEYFEELIGSTTtspVITaPDSLY---EEDGERTQIKLTFSTTTD 258
Cdd:COG0187 189 RLRELAFLNKGLTITLTdereEEPKEETFHYEGgIKDFVEYLNEDKE---PLH-PEVIYfegEKDGIEVEVALQWNDGYS 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 259 PIQESYLNLTYLSDGGSFNDGVITGIKTFCNKYARENKLFPKGINSFTTEDIESSvsfvLVA-LSNKV---EFKNQTKls 334
Cdd:COG0187 265 ENIHSFVNNINTPEGGTHETGFRTALTRVINDYARKNGLLKEKDKNLTGDDVREG----LTAvISVKLpepQFEGQTK-- 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 335 tdKKLYRKLAQRHTTQI----LEVFQIENEKGFKKFVNHLLE--------------VQKHNTQsqkakqqlkkklsekvd 396
Cdd:COG0187 339 --TKLGNSEARGIVESVvsekLEHYLEENPAEAKKILEKAILaarareaarkarelVRRKSAL----------------- 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 397 GIGNKVANLVDC-KKHGKDSEIFIAEGQSALGSIVLARDAVYQAAYPLRGKILNCLKADYTTIFKNQIITDLIKVLGCGI 475
Cdd:COG0187 400 ESSGLPGKLADCsSKDPEESELFIVEGDSAGGSAKQGRDREFQAILPLRGKILNVEKARLDKILKNEEIRDLITALGTGI 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 476 QTDkknkdldtFNINNLRYGKIIIATDQDSDGAQIACLIITMIYRLMPKLIEEGYVYIAQTPLYEIKLEDDSmIYFYSES 555
Cdd:COG0187 480 GDD--------FDLEKLRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGHVYIAQPPLYRIKKGKKT-YYAYSDA 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 556 EKDQKINTLKG--KYTIARCKGLGELDAVTMAETAMNEETRNLIKVTVEDAENMIESLETWMGSSVDNRREYISENLyKY 633
Cdd:COG0187 551 ELDELLKELKGkkKVEIQRYKGLGEMNPEQLWETTMDPETRTLLQVTIEDAAEADEIFSLLMGDKVEPRREFIEENA-KF 629
|
...
gi 1238239316 634 VEE 636
Cdd:COG0187 630 VRN 632
|
|
| PRK05559 |
PRK05559 |
DNA topoisomerase IV subunit B; Reviewed |
27-630 |
1.86e-125 |
|
DNA topoisomerase IV subunit B; Reviewed
Pssm-ID: 235501 [Multi-domain] Cd Length: 631 Bit Score: 384.45 E-value: 1.86e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 27 GSAD--NYYHGLKEILANGTDEVINNFDEGI-VTLElfDDlQTVRVTDTGRGIPIDGETD-GVKNYELLFRTLFASTKYE 102
Cdd:PRK05559 31 GSTDtrGLHHLVQEVIDNSVDEALAGHGKRIeVTLH--AD-GSVSVRDNGRGIPVGIHPEeGKSGVEVILTKLHAGGKFS 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 103 T-SEQTTTGTNGVGATVLNFTSLFFYIDSYYDGYKHTLKFEnGGELVQDLTKE-KISEDRHGTVITFKLDPEVYPVVTYD 180
Cdd:PRK05559 108 NkAYKFSGGLHGVGVSVVNALSSRLEVEVKRDGKVYRQRFE-GGDPVGPLEVVgTAGKRKTGTRVRFWPDPKIFDSPKFS 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 181 KDVVREIVRRFAI---GshkIKLIFIHNGEEETFHYES-VEEYFEELIGSTTTSPVITAPDSLYEEDGERTQIKLTFSTT 256
Cdd:PRK05559 187 PERLKERLRSKAFllpG---LTITLNDERERQTFHYENgLKDYLAELNEGKETLPEEFVGSFEGEAEGEAVEWALQWTDE 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 257 TDPIQESYLNLTYLSDGGS----FNDGVITGIKTFCNKyareNKLFPKGINsFTTEDIESSVSFVLvalSNKV---EFKN 329
Cdd:PRK05559 264 GGENIESYVNLIPTPQGGThengFREGLLKAVREFAEK----RNLLPKGKK-LEGEDVREGLAAVL---SVKIpepQFEG 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 330 QTK--LST-------DKKLYRKLAQR------HTTQILEvFQIENEKGFKKfvnhllEVQKhntqsqkakqqlkkKLSEK 394
Cdd:PRK05559 336 QTKekLGSrearrfvSGVVKDAFDLWlnqnpeLAEKLAE-KAIKAAQARLR------AAKK--------------VKRKK 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 395 VDGIGNKVANLVDCKKHGKD-SEIFIAEGQSALGSIVLARDAVYQAAYPLRGKILNCLKADYTTIFKNQIITDLIKVLGC 473
Cdd:PRK05559 395 KTSGPALPGKLADCTSQDPErTELFLVEGDSAGGSAKQARDREFQAILPLRGKILNTWEASLDDVLANEEIHDIIVAIGI 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 474 GIqtdkknkdLDTFNINNLRYGKIIIATDQDSDGAQIACLIITMIYRLMPKLIEEGYVYIAQTPLYEIKLEDDSmIYFYS 553
Cdd:PRK05559 475 GP--------GDSFDLEDLRYGKIIIMTDADVDGAHIATLLLTFFYRHFPPLVEAGHVYIALPPLYRVDKGKKK-IYALD 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 554 ESEKDQKINTL---KGKYTIARCKGLGELDAVTMAETAMNEETRNLIKVTVEDAENMIESLETWMGSSVDNRREYISENL 630
Cdd:PRK05559 546 EEEKEELLKKLgkkGGKPEIQRFKGLGEMNPDQLWETTMDPETRRLVRVTIDDAEETEKLVDMLMGKKAEPRREWIEENG 625
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
33-630 |
3.86e-116 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 359.18 E-value: 3.86e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 33 YHGLKEILANGTDEVINNF-DEGIVTLelfDDLQTVRVTDTGRGIPID-GETDGVKNYELLFRTLFASTKY-ETSEQTTT 109
Cdd:smart00433 3 HHLVDEIVDNAADEALAGYmDTIKVTI---DKDNSISVEDNGRGIPVEiHPKEKKYAPEVIFTVLHAGGKFdDDAYKVSG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 110 GTNGVGATVLNFTSLFFYIDSYYDGYKHTLKFENGGELVQDLTKEKISeDRHGTVITFKLDPEVYPVVT-YDKDVVREIV 188
Cdd:smart00433 80 GLHGVGASVVNALSTEFEVEVARDGKEYKQSFSNNGKPLSEPKIIGDT-KKDGTKVTFKPDLEIFGMTTdDDFELLKRRL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 189 RRFAIGSHKIKLIFIH--NGEEETFHYE-SVEEYFEELIGSTTTSPVITAPDSlYEEDGERTQIKLTFSTTTDPIQESYL 265
Cdd:smart00433 159 RELAFLNKGVKITLNDerSDEEKTFLFEgGIKDYVELLNKNKELLSPEPTYIE-GEKDNIRVEVAFQYTDGYSENIVSFV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 266 NLTYLSDGGSFNDGVITGIKTFCNKYARENKLFPKgiNSFTTEDI-ESSVSFVLVALSNKvEFKNQTK--LSTDKKlyRK 342
Cdd:smart00433 238 NNIATTEGGTHENGFKDALTRVINEYAKKKKKLKE--KNIKGEDVrEGLTAFISVKIPEP-QFEGQTKekLGTSEV--RF 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 343 LAQRHTTQILEVFQIENEKGFKKFVNHLLEVQKHNTQSQKAKQQLKKKLSEKVDGIGNkvanLVDC-KKHGKDSEIFIAE 421
Cdd:smart00433 313 GVEKIVSECLLSFLEENPVEASKIVEKVLLAAKARAAAKKARELTRKKKLSSISLPGK----LADAsSAGPKKCELFLVE 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 422 GQSALGSIVLARDAVYQAAYPLRGKILNCLKADYTTIFKNQIITDLIKVLGCGIQTDkknkdldtFNINNLRYGKIIIAT 501
Cdd:smart00433 389 GDSAGGSAKSGRDRDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKD--------FDIEKLRYGKIIIMT 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 502 DQDSDGAQIACLIITMIYRLMPKLIEEGYVYIAQTPLYEIKLEDDS-MIYFYSESEKDQKINTLKG---KYTIARCKGLG 577
Cdd:smart00433 461 DADVDGSHIKGLLLTFFYRYMPPLIEAGFVYIAIPPLYKVTKGKKKyVYSFYSLDEYEKWLEKTEGnksKYEIQRYKGLG 540
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|...
gi 1238239316 578 ELDAVTMAETAMNEETRNLIKVTVEDAENMIESLETWMGSSVDNRREYISENL 630
Cdd:smart00433 541 EMNADQLWETTMDPERRTLLFVTLDDADEADLIFSALMGDKVEPRKEWIEENA 593
|
|
| gyrB |
PRK05644 |
DNA gyrase subunit B; Validated |
34-636 |
2.55e-94 |
|
DNA gyrase subunit B; Validated
Pssm-ID: 235542 [Multi-domain] Cd Length: 638 Bit Score: 303.55 E-value: 2.55e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 34 HGLKEILANGTDEVINNF-DEGIVTLElfDDlQTVRVTDTGRGIPID-GETDGVKNYELLFRTLFASTKYE-TSEQTTTG 110
Cdd:PRK05644 40 HLVYEIVDNSIDEALAGYcDHIEVTIN--ED-GSITVTDNGRGIPVDiHPKTGKPAVEVVLTVLHAGGKFGgGGYKVSGG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 111 TNGVGATVLNFTSLFFYIDSYYDGYKHTLKFENGgELVQDLtkEKISE-DRHGTVITFKLDPEVYPVVTYDKDVVREIVR 189
Cdd:PRK05644 117 LHGVGVSVVNALSTWLEVEVKRDGKIYYQEYERG-VPVTPL--EVIGEtDETGTTVTFKPDPEIFETTEFDYDTLATRLR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 190 RFAIGSHKIKLIFI----HNGEEETFHYES-VEEYFEELIGSTTtsPVItaPDSLYEEdGERTQIKLTFSTT-TDPIQE- 262
Cdd:PRK05644 194 ELAFLNKGLKITLTdereGEEKEETFHYEGgIKEYVEYLNRNKE--PLH--EEPIYFE-GEKDGIEVEVAMQyNDGYSEn 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 263 --SYLNLTYLSDGGSFNDGVITGIKTFCNKYARENKLFPKGINSFTTEDI-ESsvsfvLVA-LSNKV---EFKNQTKlst 335
Cdd:PRK05644 269 ilSFANNINTHEGGTHEEGFKTALTRVINDYARKNKLLKEKDDNLTGEDVrEG-----LTAvISVKHpepQFEGQTK--- 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 336 dKKL----YRKLAQRHTTQILEVFQIENEKGFKKFVNHLLE--------------VQKHNtqsqkakqqlkkklsekVDG 397
Cdd:PRK05644 341 -TKLgnseVRGIVDSVVSEALSEFLEENPNVAKKIVEKAILaarareaarkarelTRRKS-----------------ALE 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 398 IGNKVANLVDCK-KHGKDSEIFIAEGQSALGSIVLARDAVYQAAYPLRGKILNCLKADYTTIFKNQIITDLIKVLGCGIQ 476
Cdd:PRK05644 403 SSSLPGKLADCSsKDPEESELYIVEGDSAGGSAKQGRDRRFQAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIG 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 477 TDkknkdldtFNINNLRYGKIIIATDQDSDGAQIACLIITMIYRLMPKLIEEGYVYIAQTPLYeiKLEDDSMIYFYSESE 556
Cdd:PRK05644 483 DD--------FDISKLRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGYVYIAQPPLY--KIKKGGKEYAYSDEE 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 557 KDQKINTLKG----KYTIARCKGLGELDAVTMAETAMNEETRNLIKVTVEDAENMIESLETWMGSSVDNRREYISENLyK 632
Cdd:PRK05644 553 LDEILAELKLkgnpKYGIQRYKGLGEMNPEQLWETTMDPETRTLLQVTIEDAAEADEIFSILMGDDVEPRREFIEENA-K 631
|
....
gi 1238239316 633 YVEE 636
Cdd:PRK05644 632 YVRN 635
|
|
| gyrB |
PRK14939 |
DNA gyrase subunit B; Provisional |
38-629 |
1.37e-51 |
|
DNA gyrase subunit B; Provisional
Pssm-ID: 237860 [Multi-domain] Cd Length: 756 Bit Score: 190.31 E-value: 1.37e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 38 EILANGTDEVINNF-DEGIVTLElfDDlQTVRVTDTGRGIPID-GETDGVKNYELLFRTLFASTKYE-TSEQTTTGTNGV 114
Cdd:PRK14939 44 EVVDNAIDEALAGHcDDITVTIH--AD-GSVSVSDNGRGIPTDiHPEEGVSAAEVIMTVLHAGGKFDqNSYKVSGGLHGV 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 115 GATVLNFTSLFFYIDSYYDGYKHTLKFENGgELVQDLtkEKISE-DRHGTVITFKLDPEVYPVVTYDKDV----VREI-- 187
Cdd:PRK14939 121 GVSVVNALSEWLELTIRRDGKIHEQEFEHG-VPVAPL--KVVGEtDKTGTEVRFWPSPEIFENTEFDYDIlakrLRELaf 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 188 ----VRrfaigshkIKLIFIHNGEEETFHYES-VEEYFEELigSTTTSPVITAPDSLyeeDGERTQIKLTFSTT-TDPIQ 261
Cdd:PRK14939 198 lnsgVR--------IRLKDERDGKEEEFHYEGgIKAFVEYL--NRNKTPLHPNIFYF---SGEKDGIGVEVALQwNDSYQ 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 262 E---SYLNLTYLSDGGSFndgvITGIK---TFC-NKYARENKLFPKGINSFTTEDI-ESsvsfvLVA-LSNKV---EFKN 329
Cdd:PRK14939 265 EnvlCFTNNIPQRDGGTH----LAGFRaalTRTiNNYIEKEGLAKKAKVSLTGDDArEG-----LTAvLSVKVpdpKFSS 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 330 QTK---LSTDKK------LYRKLAQrhttqILEvfqiENEKGFKKFVNHLLE--------------VQKHNTqsqkakqq 386
Cdd:PRK14939 336 QTKdklVSSEVRpaveslVNEKLSE-----FLE----ENPNEAKIIVGKIIDaarareaarkarelTRRKGA-------- 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 387 lkkklsekVDGIG--NKVAnlvDCkkHGKD---SEIFIAEGQSALGSIVLARDAVYQAAYPLRGKILNCLKADYTTIFKN 461
Cdd:PRK14939 399 --------LDIAGlpGKLA---DC--QEKDpalSELYLVEGDSAGGSAKQGRDRKFQAILPLKGKILNVEKARFDKMLSS 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 462 QIITDLIKVLGCGIQTDKknkdldtFNINNLRYGKIIIATDQDSDGAQIACLIITMIYRLMPKLIEEGYVYIAQTPLYEI 541
Cdd:PRK14939 466 QEIGTLITALGCGIGRDE-------FNPDKLRYHKIIIMTDADVDGSHIRTLLLTFFYRQMPELIERGHLYIAQPPLYKV 538
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 542 K-------LEDD---------------------------------------------------------SMIY------- 550
Cdd:PRK14939 539 KkgkqeqyLKDDealddylielalegatlhladgpaisgealeklvkeyravrkiidrlerrypravleALIYapaldld 618
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 551 ---------------------------------------FYSESEKDQKINTLK---------GK--YTIARCKGLGELD 580
Cdd:PRK14939 619 dladeaavaaldadfltsaeyrrlvelaeklrglieegaYLERGERKQPVSSFEealdwllaeARkgLSIQRYKGLGEMN 698
|
730 740 750 760
....*....|....*....|....*....|....*....|....*....
gi 1238239316 581 AVTMAETAMNEETRNLIKVTVEDAENMIESLETWMGSSVDNRREYISEN 629
Cdd:PRK14939 699 PEQLWETTMDPENRRLLQVTIEDAIAADEIFTTLMGDEVEPRREFIEEN 747
|
|
| TOPRIM_TopoIIA_like |
cd01030 |
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
415-536 |
9.58e-46 |
|
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173780 [Multi-domain] Cd Length: 115 Bit Score: 157.67 E-value: 9.58e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 415 SEIFIAEGQSALGSIVLARDAVYQAAYPLRGKILNCLKADYTTIFKNQIITDLIKVLGCGIqtdkknkDLDTFNINNLRY 494
Cdd:cd01030 1 CELILVEGDSAGGSAKQGRDRVFQAVFPLRGKILNVEKASLKKILKNEEIQNIIKALGLGI-------GKDDFDLDKLRY 73
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1238239316 495 GKIIIATDQDSDGAQIACLIITMIYRLMPKLIEEGYVYIAQT 536
Cdd:cd01030 74 GKIIIMTDADVDGSHIRTLLLTFFYRFWPSLLENGFLYIAQT 115
|
|
| PTZ00109 |
PTZ00109 |
DNA gyrase subunit b; Provisional |
36-629 |
9.31e-40 |
|
DNA gyrase subunit b; Provisional
Pssm-ID: 240272 [Multi-domain] Cd Length: 903 Bit Score: 156.19 E-value: 9.31e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 36 LKEILANGTDEViNNFDEGIVTLELFDDlQTVRVTDTGRGIPID------------------------------------ 79
Cdd:PTZ00109 134 LFEILDNSVDEY-LAGECNKITVVLHKD-GSVEISDNGRGIPCDvsektgksgletvltvlhsggkfqdtfpknsrsdks 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 80 ---GETDGVKNYELLFRTLFASTKYETSEQT---TTGTNGVGATVLNFTSLFFYIDSYYDGYKHTLKFENGgELVQDLTK 153
Cdd:PTZ00109 212 edkNDTKSSKKGKSSHVKGPKEAKEKESSQMyeySSGLHGVGLSVVNALSSFLKVDVFKGGKIYSIELSKG-KVTKPLSV 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 154 EKISEDRHGTVITFKLD---------------PEVYPVVTYDKDVVREIVRRFAIGSHKIKLIFI------HNGE--EET 210
Cdd:PTZ00109 291 FSCPLKKRGTTIHFLPDykhifkthhqhteteEEEGCKNGFNLDLIKNRIHELSYLNPGLTFYLVderianENNFypYET 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 211 FHYE-SVEEYFEELIGSTTtspvitapdSLYEEDG--------ERTQIKLTFSTTTDPIQE---SYLNLTYLSdGGSFND 278
Cdd:PTZ00109 371 IKHEgGTREFLEELIKDKT---------PLYKDINiisirgviKNVNVEVSLSWSLESYTAlikSFANNVSTT-AGTHID 440
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 279 GVITGIKTFCNKYARENKLFPKGINSFTTEDIESSVSFVLVALSNKVEFKNQTKlstdkklyRKLAQRHTTQILEvfQIE 358
Cdd:PTZ00109 441 GFKYAITRCVNGNIKKNGYFKGNFVNIPGEFIREGMTAIISVKLNGAEFDGQTK--------TKLGNHLLKTILE--SIV 510
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 359 NEKGFKKFVNH---LLEVqkHNTQSQKAKQQLKKKLSEkvDGIGNKVAN---------LVDCKKHG-KDSEIFIAEGQSA 425
Cdd:PTZ00109 511 FEQLSEILEFEpnlLLAI--YNKSLAAKKAFEEAKAAK--DLIRQKNNQyystilpgkLVDCISDDiERNELFIVEGESA 586
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 426 LGSIVLARDAVYQAAYPLRGKILNCLK-ADYTTIFKNQIITDLIKVLGCGIQTD-KKNKDL---------DTFNINN--- 491
Cdd:PTZ00109 587 AGNAKQARNREFQAVLPLKGKILNIEKiKNNKKVFENSEIKLLITSIGLSVNPVtWRQYDLshgtkaskdESVQNNNstl 666
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 492 -----------LRYGKIIIATDQDSDGAQIACLIITMIYRLMPKLIEEGYVYIAQTPLYEI-----------KLEDDSMI 549
Cdd:PTZ00109 667 tkkknslfdtpLRYGKIILLTDADVDGEHLRILLLTLLYRFCPSLYEHGRVYVACPPLYRItnnrmkqfnvsTKNSKKYI 746
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 550 YFYSESEKDQKINTLKGK-------------------------------------------------------------- 567
Cdd:PTZ00109 747 YTWSDEELNVLIKLLNKDysskettrsveekgnapdldneyedekldnknmrennvdevelktelgtnvadteqtdeldi 826
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1238239316 568 ----------YTIARCKGLGELDAVTMAETAMNEETRNLIKVTVED---AENMIESLetwMGSSVDNRREYISEN 629
Cdd:PTZ00109 827 nkaffkfskhYEIQRFKGLGEMMADQLWETTMDPKKRILIRITVSDamrASELIFLL---MGEDVQSRKQFIFEN 898
|
|
| PLN03128 |
PLN03128 |
DNA topoisomerase 2; Provisional |
38-577 |
8.46e-28 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215593 [Multi-domain] Cd Length: 1135 Bit Score: 119.81 E-value: 8.46e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 38 EILANGTDEVIN--NFDEGIVTLElfDDLQTVRVTDTGRGIPID-GETDGVKNYELLFRTLFASTKYETSEQTTT-GTNG 113
Cdd:PLN03128 59 EILVNAADNKQRdpSMDSLKVDID--VEQNTISVYNNGKGIPVEiHKEEGVYVPELIFGHLLTSSNFDDNEKKTTgGRNG 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 114 VGATVLNFTSLFFYIDSyYDG-----YKHTlkFENGGELVQD--LTKEKISEDRhgTVITFKLDPEVYPVVTYDKDVVRE 186
Cdd:PLN03128 137 YGAKLANIFSTEFTVET-ADGnrgkkYKQV--FTNNMSVKSEpkITSCKASENW--TKITFKPDLAKFNMTRLDEDVVAL 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 187 IVRRF--AIGSHKIKLIFIHNGEEETFhyESVEEYFEELIGSTTTSPvitAPDSLYEEDGERTQIKLTFSTTTDPiQESY 264
Cdd:PLN03128 212 MSKRVydIAGCLGKKLKVELNGKKLPV--KSFQDYVGLYLGPNSRED---PLPRIYEKVNDRWEVCVSLSDGSFQ-QVSF 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 265 LNLTYLSDGGSFNDGVITGIKTFC-NKYARENKlFPKGINSFTtedIESSVSFVLVALSNKVEFKNQTK--LSTDKKLYR 341
Cdd:PLN03128 286 VNSIATIKGGTHVDYVADQIVKHIqEKVKKKNK-NATHVKPFQ---IKNHLWVFVNCLIENPTFDSQTKetLTTRPSSFG 361
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 342 ---KLAQRHTTQILEVFQIENEKGFKKFvnhllevqKHNtqsqKAKQQLKKKLSEKVDGIgnkvANLVDCKKHG-KDSE- 416
Cdd:PLN03128 362 skcELSEEFLKKVEKCGVVENILSWAQF--------KQQ----KELKKKDGAKRQRLTGI----PKLDDANDAGgKKSKd 425
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 417 --IFIAEGQSA-----LGSIVLARDavYQAAYPLRGKILNCLKADYTTIFKNQIITDLIKVLGCgiqtdKKNKDLDTFNI 489
Cdd:PLN03128 426 ctLILTEGDSAkalamSGLSVVGRD--HYGVFPLRGKLLNVREASHKQIMKNAEITNIKQILGL-----QFGKTYDEENT 498
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 490 NNLRYGKIIIATDQDSDGAQIACLIITMIYRLMPKLIE-EGYVYIAQTPLYEIKLEDDSmIYFYSESEKDQKINTLKG-- 566
Cdd:PLN03128 499 KSLRYGHLMIMTDQDHDGSHIKGLIINFFHSFWPSLLKiPGFLVEFITPIVKATKGGKS-LSFYTMPEYEAWKESLEGet 577
|
570
....*....|..
gi 1238239316 567 -KYTIARCKGLG 577
Cdd:PLN03128 578 kGWTIKYYKGLG 589
|
|
| 39 |
PHA02569 |
DNA topoisomerase II large subunit; Provisional |
6-627 |
1.36e-26 |
|
DNA topoisomerase II large subunit; Provisional
Pssm-ID: 177398 [Multi-domain] Cd Length: 602 Bit Score: 114.85 E-value: 1.36e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 6 QDKIKRLDDREKSREKIAIWYGSADN---------------YYHGLKEIlangTDEVINN-FDEGIVT-------LELFD 62
Cdd:PHA02569 1 KDEFKVLSDREHILKRPGMYIGSVAYeaherflfgkftqveYVPGLVKI----IDEIIDNsVDEAIRTnfkfankIDVTI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 63 DLQTVRVTDTGRGIPIDGETDgvKNYELLFRTLFASTK------YETSEQTTTGTNGVGATVLNFTSLFFyIDSYYDGY- 135
Cdd:PHA02569 77 KNNQVTVSDNGRGIPQAMVTT--PEGEEIPGPVAAWTRtkagsnFDDTNRVTGGMNGVGSSLTNFFSVLF-IGETCDGKn 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 136 KHTLKFENGGElvqDLTKEKISEDRHGTVITFKLDP---EVYPVVTYDKDVVREIVRRFAIGSHKIKliFIHNGEEetfh 212
Cdd:PHA02569 154 EVTVNCSNGAE---NISWSTKPGKGKGTSVTFIPDFshfEVNGLDQQYLDIILDRLQTLAVVFPDIK--FTFNGKK---- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 213 yesVEEYFEELIGSTTTSPVITapdslyeedgERTQIKLTFSTTTDPI-QESYLNLTYLSDGGSFNDGVITGI-----KT 286
Cdd:PHA02569 225 ---VSGKFKKYAKQFGDDTIVQ----------ENDNVSIALAPSPDGFrQLSFVNGLHTKNGGHHVDCVMDDIceeliPM 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 287 FCNKYARE-NK----------LFPKGIN-----SFTTEDIESSVSfvlvalsnkvEFKNQTKLSTdKKLYRKLAQRHT-- 348
Cdd:PHA02569 292 IKKKHKIEvTKarvkecltivLFVRNMSnprfdSQTKERLTSPFG----------EIRNHIDLDY-KKIAKQILKTEAii 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 349 TQILEVFQIENEKGFKKfvnHLLEVQKHNTQSqkakqqlkkklsekvdgignKVANLVDCKKHGKDSE--IFIAEGQSAL 426
Cdd:PHA02569 361 MPIIEAALARKLAAEKA---AETKAAKKAKKA--------------------KVAKHIKANLIGKDAEttLFLTEGDSAI 417
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 427 GSIVLARDAVYQAAYPLRGKILNCLKADYTTIFKNQIITDLIKVLGcgiqTDKKNKDLdtfninNLRYGKIIIATDQDSD 506
Cdd:PHA02569 418 GYLIEVRDEELHGGYPLRGKVLNTWGMSYADILKNKELFDICAITG----LVLGEKAE------NMNYKNIAIMTDADVD 487
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 507 G-AQIACLIITMIYRlMPKLIEEGYVYIAQTPLY--EIKLEDDsmiYFYSESEKDQKINTLKgKYTIARCKGLGELDavt 583
Cdd:PHA02569 488 GkGSIYPLLLAFFSR-WPELFEQGRIRFVKTPVIiaQVGKETK---WFYSLDEFEKAKDSLK-KWSIRYIKGLGSLR--- 559
|
650 660 670 680
....*....|....*....|....*....|....*....|....
gi 1238239316 584 maETAMNEETRNLIKVTVEDAENMIESLETWMGSSVDNRREYIS 627
Cdd:PHA02569 560 --KSEYRRVINNPVYDVVVLPDDWKELFEMLFGDDADLRKDWMS 601
|
|
| PLN03237 |
PLN03237 |
DNA topoisomerase 2; Provisional |
33-577 |
9.54e-24 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215641 [Multi-domain] Cd Length: 1465 Bit Score: 106.87 E-value: 9.54e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 33 YHGLKEILANGTDEVINnfDEGIVTLELFDDLQ--TVRVTDTGRGIPID-GETDGVKNYELLFRTLFASTKYETSEQTTT 109
Cdd:PLN03237 79 YKIFDEILVNAADNKQR--DPKMDSLRVVIDVEqnLISVYNNGDGVPVEiHQEEGVYVPEMIFGHLLTSSNYDDNEKKTT 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 110 G-TNGVGATVLNFTSLFFYIDSYyDG-----YKHTLKFENGGELVQDLTKEKISEDrhGTVITFKLDPEVYPVVTYDKDV 183
Cdd:PLN03237 157 GgRNGYGAKLTNIFSTEFVIETA-DGkrqkkYKQVFSNNMGKKSEPVITKCKKSEN--WTKVTFKPDLAKFNMTHLEDDV 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 184 VREIVRRF-----AIG-SHKIKLifihNGEEetFHYESVEEYFEELIGSTTTSPVITAPdSLYEEDGERTQIKLTFSTTT 257
Cdd:PLN03237 234 VALMKKRVvdiagCLGkTVKVEL----NGKR--IPVKSFSDYVDLYLESANKSRPENLP-RIYEKVNDRWEVCVSLSEGQ 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 258 DPiQESYLNLTYLSDGGSFNDGVITGIKTFC-NKYARENKlfpkgiNSFTTEDIESSVSFVLV-ALSNKVEFKNQTK--L 333
Cdd:PLN03237 307 FQ-QVSFVNSIATIKGGTHVDYVTNQIANHVmEAVNKKNK------NANIKAHNVKNHLWVFVnALIDNPAFDSQTKetL 379
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 334 STDKKLYR---KLAQRHTTQILEVFQIENEKGFKKFvnhllevqKHNTQSqkakqqlkkklsEKVDGIG----NKVANLV 406
Cdd:PLN03237 380 TLRQSSFGskcELSEDFLKKVMKSGIVENLLSWADF--------KQSKEL------------KKTDGAKttrvTGIPKLE 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 407 DCKKHG-KDSE---IFIAEGQSA-----LGSIVLARDavYQAAYPLRGKILNCLKADYTTIFKNQIITDLIKVLGCgiqt 477
Cdd:PLN03237 440 DANEAGgKNSEkctLILTEGDSAkalavAGLSVVGRN--YYGVFPLRGKLLNVREASHKQIMNNAEIENIKQILGL---- 513
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 478 dKKNKDLDtfNINNLRYGKIIIATDQDSDGAQIACLIITMIYRLMPKLIE-EGYVYIAQTPLYEIKLEDDSMIYFYSESE 556
Cdd:PLN03237 514 -QHGKQYE--SVKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKvPSFLVEFITPIVKATRRGKKVLSFYSMPE 590
|
570 580
....*....|....*....|....
gi 1238239316 557 KDQKINTLKGK---YTIARCKGLG 577
Cdd:PLN03237 591 YEEWKESLGGNatgWSIKYYKGLG 614
|
|
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
31-577 |
1.32e-23 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 106.67 E-value: 1.32e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 31 NYYHGL----KEILANGTDEVINNFDEGIVT---LELFDDLQTVRVTDTGRGIPID-GETDGVKNYELLFRTLFASTKYE 102
Cdd:PTZ00108 53 TYVPGLykifDEILVNAADNKARDKGGHRMTyikVTIDEENGEISVYNDGEGIPVQiHKEHKIYVPEMIFGHLLTSSNYD 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 103 TSEQTTT-GTNGVGATVLNFTSLFFYI---DSYyDGYKHTLKFENGGELVQDLTKEKISEDRHGTVITFKLDPEVYPVVT 178
Cdd:PTZ00108 133 DTEKRVTgGRNGFGAKLTNIFSTKFTVecvDSK-SGKKFKMTWTDNMSKKSEPRITSYDGKKDYTKVTFYPDYAKFGMTE 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 179 YDKDVVREIVRR---FAIGSHKIKLIFihNGEEetFHYESVEEYFeeLIGSTTTSPVITAPDS-LYEEDGERTQIKLTFS 254
Cdd:PTZ00108 212 FDDDMLRLLKKRvydLAGCFGKLKVYL--NGER--IAIKSFKDYV--DLYLPDGEEGKKPPYPfVYTSVNGRWEVVVSLS 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 255 TTTdPIQESYLNLTYLSDGGSFNDGVITGIKTFCNKYARENKlfpKGINSFTTEDIESSVsFVLV-ALSNKVEFKNQTK- 332
Cdd:PTZ00108 286 DGQ-FQQVSFVNSICTTKGGTHVNYILDQLISKLQEKAKKKK---KKGKEIKPNQIKNHL-WVFVnCLIVNPSFDSQTKe 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 333 -LSTDKKLY---RKLAQRHTTQILEvfqienekgfKKFVNHLLEvQKHNTQSQKAKQQLKKKLSEKVDGIgnkvANLVDC 408
Cdd:PTZ00108 361 tLTTKPSKFgstCELSEKLIKYVLK----------SPILENIVE-WAQAKLAAELNKKMKAGKKSRILGI----PKLDDA 425
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 409 ----KKHGKDSEIFIAEGQSA----LGSI-VLARDavYQAAYPLRGKILNCLKADYTTIFKNQIITDLIKVLGCGIQTDK 479
Cdd:PTZ00108 426 ndagGKNSEECTLILTEGDSAkalaLAGLsVVGRD--YYGVFPLRGKLLNVRDASLKQLMNNKEIQNLFKILGLDIGKKY 503
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 480 KNkdldtfnINNLRYGKIIIATDQDSDGAQIACLIITMIYRLMPKLIE-EGYVYIAQTPLYEIKLEDDSMIYFYS--ESE 556
Cdd:PTZ00108 504 ED-------PKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKnPGFLKEFITPIVKATKKGNQVISFFTipDFE 576
|
570 580
....*....|....*....|.
gi 1238239316 557 KDQKINTLKGkYTIARCKGLG 577
Cdd:PTZ00108 577 KWKQTVGLKG-WKIKYYKGLG 596
|
|
| HATPase_GyrB-like |
cd16928 |
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ... |
32-211 |
4.12e-23 |
|
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.
Pssm-ID: 340405 [Multi-domain] Cd Length: 180 Bit Score: 96.84 E-value: 4.12e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 32 YYHGLKEILANGTDEVINNF-DEGIVTLElfDDlQTVRVTDTGRGIPID-GETDGVKNYELLFRTLFASTKYE-TSEQTT 108
Cdd:cd16928 1 LHHLVWEIVDNSIDEALAGYaTEIEVTLH--ED-NSITVEDNGRGIPVDiHPKTGKSAVEVVLTVLHAGGKFDgGSYKVS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 109 TGTNGVGATVLNFTSLFFYIDSYYDGYKHTLKFENGGeLVQDLtkEKISE-DRHGTVITFKLDPEVYPVVTYDKDVVREI 187
Cdd:cd16928 78 GGLHGVGVSVVNALSERLEVEVKRDGKIYRQEFSRGG-PLTPL--EVIGEtKKTGTTVRFWPDPEIFEKTEFDFDTLKRR 154
|
170 180
....*....|....*....|....*.
gi 1238239316 188 VRRFAIGSHKIKLIFI--HNGEEETF 211
Cdd:cd16928 155 LRELAFLNKGLKIVLEdeRTGKEEVF 180
|
|
| TOPRIM_TopoIIA |
cd03365 |
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
421-526 |
8.66e-19 |
|
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173785 [Multi-domain] Cd Length: 120 Bit Score: 82.35 E-value: 8.66e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 421 EGQSAL-----GSIVLARDavYQAAYPLRGKILNCLKADYTTIFKNQIITDLIKVLGcgIQTDKKNKDldtfNINNLRYG 495
Cdd:cd03365 7 EGDSAKalavaGLSVVGRD--YYGVFPLRGKLLNVREASHKQIMENAEIQNIKKILG--LQHGKSDYE----STKSLRYG 78
|
90 100 110
....*....|....*....|....*....|.
gi 1238239316 496 KIIIATDQDSDGAQIACLIITMIYRLMPKLI 526
Cdd:cd03365 79 RLMIMTDQDHDGSHIKGLLINFIHSFWPSLL 109
|
|
| DNA_gyraseB_C |
pfam00986 |
DNA gyrase B subunit, carboxyl terminus; The amino terminus of eukaryotic and prokaryotic DNA ... |
565-626 |
9.27e-17 |
|
DNA gyrase B subunit, carboxyl terminus; The amino terminus of eukaryotic and prokaryotic DNA topoisomerase II are similar, but they have a different carboxyl terminus. The amino-terminal portion of the DNA gyrase B protein is thought to catalyze the ATP-dependent super-coiling of DNA. See pfam00204. The carboxyl-terminal end supports the complexation with the DNA gyrase A protein and the ATP-independent relaxation. This family also contains Topoisomerase IV. This is a bacterial enzyme that is closely related to DNA gyrase,.
Pssm-ID: 460016 [Multi-domain] Cd Length: 63 Bit Score: 74.72 E-value: 9.27e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1238239316 565 KGKYTIARCKGLGELDAVTMAETAMNEETRNLIKVTVEDAENMIESLETWMGSSVDNRREYI 626
Cdd:pfam00986 1 KKKVEIQRYKGLGEMNPEQLWETTMDPETRRLLQVTIEDAAEADEIFSTLMGDKVEPRREFI 62
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
416-536 |
1.18e-10 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 58.52 E-value: 1.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 416 EIFIAEGQSALGSIVLARDAVYQAAYPLRGKILNclkadyttifknqiitdlikvlgcgIQTDKKNKDLDTFNINNLRYG 495
Cdd:pfam01751 1 ELIIVEGPSDAIALEKALGGGFQAVVAVLGHLLS-------------------------LEKGPKKKALKALKELALKAK 55
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1238239316 496 KIIIATDQDSDGAQIACLIITMiYRLMPKLIeeGYVYIAQT 536
Cdd:pfam01751 56 EVILATDPDREGEAIALKLLEL-KELLENAG--GRVEFSEL 93
|
|
| DNA_gyraseB |
pfam00204 |
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal ... |
216-332 |
1.63e-08 |
|
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.
Pssm-ID: 425522 [Multi-domain] Cd Length: 173 Bit Score: 54.54 E-value: 1.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 216 VEEYFEELIGSTTT--SPVITaPDSLYEEDGERTQIKLTFSTTTDPIQESYLNLTYLSDGGSFNDGVITGI-KTFcNKYA 292
Cdd:pfam00204 2 LKDFVEELNKDKKPlhKEIIY-FEGESPDNRIEVEVALQWTDSYSENILSFVNNIATPEGGTHVDGFKSALtRTI-NEYA 79
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1238239316 293 RENKLFPKGINSFTTEDIESSVSFVLVALSNKVEFKNQTK 332
Cdd:pfam00204 80 KKKGLLKKKDEKITGEDIREGLTAVVSVKIPDPQFEGQTK 119
|
|
| HATPase_TopII-like |
cd16930 |
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ... |
32-170 |
1.75e-05 |
|
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.
Pssm-ID: 340407 [Multi-domain] Cd Length: 147 Bit Score: 45.02 E-value: 1.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 32 YYHGL----KEILANGTDEVINNFDEGIVTLELFDDLQTVRVTDTGRGIPID-GETDGVKNYELLFRTLFASTKYETSEQ 106
Cdd:cd16930 1 YVPGLykifDEILVNAADNKQRDKSMTCIKVTIDPENNEISVWNNGKGIPVViHKEEKIYVPEMIFGHLLTSSNYDDDEK 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 107 TTT-GTNGVGATVLNFTSLFFYIDSYYDGYKHTLK--FENGgelVQDLTKEKISEDRHG---TVITFKLD 170
Cdd:cd16930 81 KVTgGRNGYGAKLCNIFSTEFTVETADSESKKKFKqtWTNN---MGKASEPKITPYEKGkdyTKVTFKPD 147
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
33-172 |
2.04e-04 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 41.20 E-value: 2.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 33 YHGLKEILANGTDEVINNfDEGIVTLELFDDLqTVRVTDTGRGIPIDgetdgvkNYELLFrtlfasTKYETSEQTTTGTN 112
Cdd:pfam02518 7 RQVLSNLLDNALKHAAKA-GEITVTLSEGGEL-TLTVEDNGIGIPPE-------DLPRIF------EPFSTADKRGGGGT 71
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 113 GVGATVLNFTSLFFyidsyydgykhtlkfenGGELvqdltkEKISEDRHGTVITFKLDPE 172
Cdd:pfam02518 72 GLGLSIVRKLVELL-----------------GGTI------TVESEPGGGTTVTLTLPLA 108
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
33-172 |
1.25e-03 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 38.78 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238239316 33 YHGLKEILANGTDEVinnFDEGIVTLELFDDLQ--TVRVTDTGRGIPIDgetdgvkNYELLFRTLFastKYETSEQTTTG 110
Cdd:smart00387 7 RQVLSNLLDNAIKYT---PEGGRITVTLERDGDhvEITVEDNGPGIPPE-------DLEKIFEPFF---RTDKRSRKIGG 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1238239316 111 TnGVG-ATVLNFTSLFfyidsyydgykhtlkfenGGELvqdltkEKISEDRHGTVITFKLDPE 172
Cdd:smart00387 74 T-GLGlSIVKKLVELH------------------GGEI------SVESEPGGGTTFTITLPLE 111
|
|
| |
