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Conserved domains on  [gi|1238240780|gb|PAM77335|]
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ABC transporter permease [Bacillus subtilis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EfiE super family cl44026
Predicted lantabiotic-exporting membrane pepmease, EfiE/EfiG/ABC2 family [Defense mechanisms];
1-218 7.26e-07

Predicted lantabiotic-exporting membrane pepmease, EfiE/EfiG/ABC2 family [Defense mechanisms];


The actual alignment was detected with superfamily member COG4200:

Pssm-ID: 443354 [Multi-domain]  Cd Length: 250  Bit Score: 48.41  E-value: 7.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238240780   1 MNLIRIELRKMK--MGWYIRGALIANVIIMGFMWLISYSEKADGGVSFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVIS 78
Cdd:COG4200     3 LRLLRAELLKLKrsLIWLLVLLLPLLSALLGLFNYLLNYEILQPYNDGDGWLSLWTQSFLFWSFFFLPLLIALLASLLAR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238240780  79 -EYKNKTILVMFTYPISRKKLLTAKLMIAGGLTFITILLSNILIAAGFFWLNsichfipgeLTSEIISQQAVKMAVFAFG 157
Cdd:COG4200    83 lEHKNGNWKQLLTLPVSRAKLYLAKLLVVALLLLLSQLLFFVLYLLSGLLLG---------LSGSIPWGELLKWLLLGWL 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1238240780 158 AAgTSLVPI--FFGMRRHSVPATI---ISSVVIVMLISSTSPGFSIssvvYIPLSLAAFGLFFSYM 218
Cdd:COG4200   154 AS-LPLIALqlWLSLRFRSFAAPVgigIVGTIAGLLASVTGSGLGY----YYPWSLPVLGMRSNGL 214
 
Name Accession Description Interval E-value
EfiE COG4200
Predicted lantabiotic-exporting membrane pepmease, EfiE/EfiG/ABC2 family [Defense mechanisms];
1-218 7.26e-07

Predicted lantabiotic-exporting membrane pepmease, EfiE/EfiG/ABC2 family [Defense mechanisms];


Pssm-ID: 443354 [Multi-domain]  Cd Length: 250  Bit Score: 48.41  E-value: 7.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238240780   1 MNLIRIELRKMK--MGWYIRGALIANVIIMGFMWLISYSEKADGGVSFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVIS 78
Cdd:COG4200     3 LRLLRAELLKLKrsLIWLLVLLLPLLSALLGLFNYLLNYEILQPYNDGDGWLSLWTQSFLFWSFFFLPLLIALLASLLAR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238240780  79 -EYKNKTILVMFTYPISRKKLLTAKLMIAGGLTFITILLSNILIAAGFFWLNsichfipgeLTSEIISQQAVKMAVFAFG 157
Cdd:COG4200    83 lEHKNGNWKQLLTLPVSRAKLYLAKLLVVALLLLLSQLLFFVLYLLSGLLLG---------LSGSIPWGELLKWLLLGWL 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1238240780 158 AAgTSLVPI--FFGMRRHSVPATI---ISSVVIVMLISSTSPGFSIssvvYIPLSLAAFGLFFSYM 218
Cdd:COG4200   154 AS-LPLIALqlWLSLRFRSFAAPVgigIVGTIAGLLASVTGSGLGY----YYPWSLPVLGMRSNGL 214
ABC-2_lan_permease-like cd21809
lantibiotic immunity ABC transporter permease (also called ABC-2 transporter permease) subunit ...
 6-129 6.87e-04

lantibiotic immunity ABC transporter permease (also called ABC-2 transporter permease) subunit and similar proteins; This subfamily contains lantibiotic ABC transporter permease subunits which are highly hydrophobic, integral membrane proteins, and part of the bacitracin ABC transport system that confers resistance to the Gram-positive bacteria in which this system operates, particularly to type-A lantibiotics. Lantibiotics are small peptides, produced by Gram-positive bacteria, which are ribosomally-synthesized as pre-peptides and act by disrupting membrane integrity. Genes encoding the lantibiotic ABC transporter subunits are highly organized in operons containing all the genes required for maturation, transport, immunity, and synthesis. For example, in Lactococcus lactis, the lantibiotic nisin is active against other Gram-positive bacteria via various modes of actions; however, its self-protection against the pore-forming nisin is mediated by the ABC transporter composed of NisF, NisE and NisG; the NisG permease subunit transports nisin to the surface and expels it from the membrane. This family includes mostly uncharacterized transport permease subunits that transport lantibiotics to the surface and expel them from the membrane.


Pssm-ID: 409634  Cd Length: 235  Bit Score: 39.49  E-value: 6.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238240780   6 IELRKMKMGWYIRGALIANVIIMGFMWLISYSEKaDGGVSFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVIS-EYKNKT 84
Cdd:cd21809     1 AEWLKLKRSKIWLLVLLAPLLAVLLGLLNFLRNK-DILVKDNPWWSLLTQVVLFYGLLFLPLLIGILASLVCRiEHKNNG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1238240780  85 ILVMFTYPISRKKLLTAKLMIAGGLTFITILLSNILIAAGFFWLN 129
Cdd:cd21809    80 WKQLLALPVSRTQIYLAKFLVVLLLLALTQLLFLGAIILGGLLLG 124
 
Name Accession Description Interval E-value
EfiE COG4200
Predicted lantabiotic-exporting membrane pepmease, EfiE/EfiG/ABC2 family [Defense mechanisms];
1-218 7.26e-07

Predicted lantabiotic-exporting membrane pepmease, EfiE/EfiG/ABC2 family [Defense mechanisms];


Pssm-ID: 443354 [Multi-domain]  Cd Length: 250  Bit Score: 48.41  E-value: 7.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238240780   1 MNLIRIELRKMK--MGWYIRGALIANVIIMGFMWLISYSEKADGGVSFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVIS 78
Cdd:COG4200     3 LRLLRAELLKLKrsLIWLLVLLLPLLSALLGLFNYLLNYEILQPYNDGDGWLSLWTQSFLFWSFFFLPLLIALLASLLAR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238240780  79 -EYKNKTILVMFTYPISRKKLLTAKLMIAGGLTFITILLSNILIAAGFFWLNsichfipgeLTSEIISQQAVKMAVFAFG 157
Cdd:COG4200    83 lEHKNGNWKQLLTLPVSRAKLYLAKLLVVALLLLLSQLLFFVLYLLSGLLLG---------LSGSIPWGELLKWLLLGWL 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1238240780 158 AAgTSLVPI--FFGMRRHSVPATI---ISSVVIVMLISSTSPGFSIssvvYIPLSLAAFGLFFSYM 218
Cdd:COG4200   154 AS-LPLIALqlWLSLRFRSFAAPVgigIVGTIAGLLASVTGSGLGY----YYPWSLPVLGMRSNGL 214
ABC-2_lan_permease-like cd21809
lantibiotic immunity ABC transporter permease (also called ABC-2 transporter permease) subunit ...
 6-129 6.87e-04

lantibiotic immunity ABC transporter permease (also called ABC-2 transporter permease) subunit and similar proteins; This subfamily contains lantibiotic ABC transporter permease subunits which are highly hydrophobic, integral membrane proteins, and part of the bacitracin ABC transport system that confers resistance to the Gram-positive bacteria in which this system operates, particularly to type-A lantibiotics. Lantibiotics are small peptides, produced by Gram-positive bacteria, which are ribosomally-synthesized as pre-peptides and act by disrupting membrane integrity. Genes encoding the lantibiotic ABC transporter subunits are highly organized in operons containing all the genes required for maturation, transport, immunity, and synthesis. For example, in Lactococcus lactis, the lantibiotic nisin is active against other Gram-positive bacteria via various modes of actions; however, its self-protection against the pore-forming nisin is mediated by the ABC transporter composed of NisF, NisE and NisG; the NisG permease subunit transports nisin to the surface and expels it from the membrane. This family includes mostly uncharacterized transport permease subunits that transport lantibiotics to the surface and expel them from the membrane.


Pssm-ID: 409634  Cd Length: 235  Bit Score: 39.49  E-value: 6.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238240780   6 IELRKMKMGWYIRGALIANVIIMGFMWLISYSEKaDGGVSFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVIS-EYKNKT 84
Cdd:cd21809     1 AEWLKLKRSKIWLLVLLAPLLAVLLGLLNFLRNK-DILVKDNPWWSLLTQVVLFYGLLFLPLLIGILASLVCRiEHKNNG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1238240780  85 ILVMFTYPISRKKLLTAKLMIAGGLTFITILLSNILIAAGFFWLN 129
Cdd:cd21809    80 WKQLLALPVSRTQIYLAKFLVVLLLLALTQLLFLGAIILGGLLLG 124
NosY COG1277
ABC-type transport system involved in multi-copper enzyme maturation, permease component ...
 1-128 2.46e-03

ABC-type transport system involved in multi-copper enzyme maturation, permease component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440888 [Multi-domain]  Cd Length: 201  Bit Score: 37.87  E-value: 2.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238240780   1 MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGVSFqstdEAFLIIGTFVRAVFIVFGAVLIVKLVISEY 80
Cdd:COG1277     2 LAIARKEFRDLFRSPRFYVLLALFLLLALLLAYLGGAASGFLGLGL----ALLASLFSLLSLLLPLLAPALGMDAISGER 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1238240780  81 KNKTILVMFTYPISRKKLLTAKLmIAGGLTFITILLSNILIAAGFFWL 128
Cdd:COG1277    78 ESGTLELLLTLPISRWEIVLGKF-LGALLVLLLALLITFLLALLLGLL 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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