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Conserved domains on  [gi|1238243457|gb|PAM79942|]
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ATP-binding protein [Bacillus subtilis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WalK super family cl34860
Sensor histidine kinase WalK [Signal transduction mechanisms];
2-55 2.25e-27

Sensor histidine kinase WalK [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5002:

Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 100.78  E-value: 2.25e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   2 FDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLPA 55
Cdd:COG5002   334 FERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPL 387
 
Name Accession Description Interval E-value
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
2-55 2.25e-27

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 100.78  E-value: 2.25e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   2 FDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLPA 55
Cdd:COG5002   334 FERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPL 387
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 1-54 4.51e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 81.00  E-value: 4.51e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   1 MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:cd16922    56 LFEPFSQADSSTTRKYGGTGLGLAISKKLVELMGGDISVESEPGQGSTFTFTLP 109
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 1-54 1.13e-18

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 72.30  E-value: 1.13e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457    1 MFDRFYKADPsRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:smart00387  57 IFEPFFRTDK-RSRKIGGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITLP 109
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
1-54 1.13e-18

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 77.12  E-value: 1.13e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   1 MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIgRGTVFLIRLP 54
Cdd:PRK09835  427 LFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLP 479
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 1-54 5.00e-18

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 75.50  E-value: 5.00e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   1 MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRgTVFLIRLP 54
Cdd:TIGR01386 405 LFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRFP 457
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 1-56 2.18e-15

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 63.93  E-value: 2.18e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1238243457   1 MFDRFYKADpsrSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLPAP 56
Cdd:pfam02518  56 IFEPFSTAD---KRGGGGTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTLPLA 108
 
Name Accession Description Interval E-value
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
2-55 2.25e-27

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 100.78  E-value: 2.25e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   2 FDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLPA 55
Cdd:COG5002   334 FERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPL 387
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 1-54 4.51e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 81.00  E-value: 4.51e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   1 MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:cd16922    56 LFEPFSQADSSTTRKYGGTGLGLAISKKLVELMGGDISVESEPGQGSTFTFTLP 109
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
2-56 1.62e-21

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 84.19  E-value: 1.62e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1238243457   2 FDRFYKADPSRsrKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLPAP 56
Cdd:COG0642   276 FEPFFRTDPSR--RGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
1-55 3.97e-21

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 81.88  E-value: 3.97e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1238243457   1 MFDRFYKADpsRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLPA 55
Cdd:COG2205   184 IFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 1-54 1.13e-18

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 72.30  E-value: 1.13e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457    1 MFDRFYKADPsRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:smart00387  57 IFEPFFRTDK-RSRKIGGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITLP 109
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
1-54 1.13e-18

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 77.12  E-value: 1.13e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   1 MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIgRGTVFLIRLP 54
Cdd:PRK09835  427 LFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLP 479
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 1-54 5.00e-18

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 75.50  E-value: 5.00e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   1 MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRgTVFLIRLP 54
Cdd:TIGR01386 405 LFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRFP 457
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
15-57 1.60e-17

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 73.73  E-value: 1.60e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1238243457  15 KYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLPAPD 57
Cdd:COG3852   314 KEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQ 356
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 17-55 9.42e-16

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 68.67  E-value: 9.42e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1238243457  17 GGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLPA 55
Cdd:COG4191   322 KGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
3-55 1.01e-15

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 68.88  E-value: 1.01e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1238243457   3 DRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLPA 55
Cdd:PRK11006  371 ERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPE 423
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 2-55 1.67e-15

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 68.06  E-value: 1.67e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   2 FDRFYkadpsrSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLPA 55
Cdd:COG5000   370 FEPFF------TTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPL 417
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 1-56 2.18e-15

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 63.93  E-value: 2.18e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1238243457   1 MFDRFYKADpsrSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLPAP 56
Cdd:pfam02518  56 IFEPFSTAD---KRGGGGTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTLPLA 108
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 2-54 5.30e-15

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 66.92  E-value: 5.30e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1238243457   2 FDRFYkadpsrSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:COG5809   433 GEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 12-55 6.70e-15

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 66.73  E-value: 6.70e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1238243457  12 RSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLPA 55
Cdd:COG4251   457 SRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPK 500
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 18-56 1.37e-14

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 65.52  E-value: 1.37e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1238243457  18 GSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLPAP 56
Cdd:COG5805   458 GTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
1-54 1.72e-14

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 65.37  E-value: 1.72e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   1 MFDRFYKADPSrsrkygGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:PRK11360  553 IFDPFFTTKAK------GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
KinC COG5807
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ...
 9-54 2.01e-14

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444509 [Multi-domain]  Cd Length: 358  Bit Score: 65.19  E-value: 2.01e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1238243457   9 DPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:COG5807   311 EPFFTTKEEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLP 356
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
1-54 6.70e-14

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 63.50  E-value: 6.70e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1238243457   1 MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVK-SEIGrGTVFLIRLP 54
Cdd:PRK10549  404 LFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAhSPFG-GVSITVELP 457
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 1-54 1.09e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 59.71  E-value: 1.09e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   1 MFDRFYKADpsRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEiGRGTVFLIRLP 54
Cdd:cd16923    52 LFERFYRGD--NSRNTEGAGLGLSIAKAIIELHGGSASAEYD-DNHDLFKVRLP 102
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 1-54 1.18e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 59.78  E-value: 1.18e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1238243457   1 MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVK-SEIGrGTVFLIRLP 54
Cdd:cd16946    56 LFERFYRVESSRNRASGGSGLGLAICHNIALAHGGTISAEhSPLG-GLRLVLTLP 109
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 1-54 1.45e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 59.36  E-value: 1.45e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   1 MFDRFYKADPSRSrkygGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:cd16943    55 IFDPFFTTKPVGE----GTGLGLSLSYRIIQKHGGTIRVASVPGGGTRFTIILP 104
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 3-54 1.60e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 59.52  E-value: 1.60e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1238243457   3 DRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:cd16952    54 ERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDARLLIASELGKGSRFTCLFP 105
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 1-55 3.44e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 55.79  E-value: 3.44e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1238243457   1 MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLPA 55
Cdd:cd16949    50 IFLPFYRVDSARDRESGGTGLGLAIAERAIEQHGGKIKASNRKPGGLRVRIWLPA 104
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 1-54 5.97e-12

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 55.19  E-value: 5.97e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   1 MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:cd16925    57 IFERFRQGDGSSTRAHGGTGLGLSIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 2-54 8.67e-12

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 57.55  E-value: 8.67e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1238243457   2 FDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:PRK11107  465 FQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLP 517
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 17-54 1.04e-11

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 57.55  E-value: 1.04e-11
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1238243457  17 GGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:COG3290   348 EGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLP 385
PRK10604 PRK10604
sensor protein RstB; Provisional
 2-56 2.98e-11

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 56.15  E-value: 2.98e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1238243457   2 FDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEV-KSEIGrGTVFLIRLPAP 56
Cdd:PRK10604  370 FEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCdESELG-GARFSFSWPVW 424
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
9-54 3.85e-11

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 55.95  E-value: 3.85e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1238243457   9 DPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:PRK10364  402 TPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 1-54 1.64e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 51.56  E-value: 1.64e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   1 MFDRFYKADPSRsrKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:cd16921    54 VFGIFQRLHSRE--EYEGTGVGLAIVRKIIERHGGRIWLESEPGEGTTFYFTLP 105
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 1-55 2.63e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 50.89  E-value: 2.63e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1238243457   1 MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEV-KSEIGrGTVFLIRLPA 55
Cdd:cd16939    50 VFEPFVRLDPSRDRATGGFGLGLAIVHRVALWHGGHVECdDSELG-GACFRLTWPR 104
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 9-54 2.92e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 50.86  E-value: 2.92e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1238243457   9 DPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRgTVFLIRLP 54
Cdd:cd16918    65 YPMVSGRENGTGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 2-56 3.15e-10

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 53.41  E-value: 3.15e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1238243457   2 FDRFYKADPSRSRKYG-GSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLPAP 56
Cdd:PRK11091  451 FAMYYQVKDSHGGKPAtGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHAP 506
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
17-54 3.70e-10

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 53.14  E-value: 3.70e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1238243457  17 GGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:PRK13837  637 GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
2-54 4.07e-10

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 53.01  E-value: 4.07e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   2 FDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEV-KSEIGrGTVFLIRLP 54
Cdd:PRK09470  404 FRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAeDSPLG-GLRLTIWLP 456
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 1-53 4.85e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 50.97  E-value: 4.85e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1238243457   1 MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRL 53
Cdd:cd16947    72 VFERLYTLEDSRNSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
1-54 8.71e-10

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 51.90  E-value: 8.71e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   1 MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:PRK10841  613 LFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
glnL PRK11073
nitrogen regulation protein NR(II);
5-54 9.75e-10

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 52.01  E-value: 9.75e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1238243457   5 FYkadPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRgTVFLIRLP 54
Cdd:PRK11073  301 FY---PMVSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLP 346
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 1-54 2.92e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 48.16  E-value: 2.92e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   1 MFDRFYKADPSrsrkygGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:cd16920    57 LFDPFYTTKSE------GLGMGLSICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 1-54 1.07e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 46.90  E-value: 1.07e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   1 MFDRFYKADPSRSRkyggsGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:cd16915    56 VFERGVSTKGQGER-----GIGLALVRQSVERLGGSITVESEPGGGTTFSIRIP 104
CheA COG0643
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
18-54 1.82e-08

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];


Pssm-ID: 440408 [Multi-domain]  Cd Length: 563  Bit Score: 48.25  E-value: 1.82e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1238243457  18 GSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:COG0643   381 GRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLP 417
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 18-54 1.98e-08

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 47.58  E-value: 1.98e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1238243457  18 GSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:cd16916   142 GRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 1-53 2.31e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 46.25  E-value: 2.31e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1238243457   1 MFDRFYKADPsrsRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRL 53
Cdd:cd16940    64 LFERFYRSDG---QNYGGSGLGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 1-54 1.07e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 44.36  E-value: 1.07e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   1 MFDRFYKADPSRSrkYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:cd16950    50 LFQPFYRGDNARG--TSGTGLGLAIVQRISDAHGGSLTLANRAGGGLCARIELP 101
envZ PRK09467
osmolarity sensor protein; Provisional
 1-57 2.22e-07

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 45.29  E-value: 2.22e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1238243457   1 MFDRFYKADPSRSRKygGSGLGLAITKSIIDNHNGTIEV-KSEIGrGTVFLIRLPAPD 57
Cdd:PRK09467  381 LFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVELgNSEEG-GLSARAWLPLTT 435
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 1-54 5.62e-07

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 44.13  E-value: 5.62e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457   1 MFDRFYkadpsrSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:PRK11086  487 IFDKGY------STKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 13-54 7.22e-07

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 43.74  E-value: 7.22e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1238243457  13 SRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:PRK11466  620 SGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 2-56 1.17e-06

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 43.29  E-value: 1.17e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1238243457   2 FDRFYK-ADPSRSRKygGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLPAP 56
Cdd:PRK11100  421 FERFYSlPRPANGRK--STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRH 474
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
1-54 1.54e-06

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 42.80  E-value: 1.54e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1238243457    1 MFDRFykADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:PRK09959   884 LFKRY--SQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
PRK10490 PRK10490
sensor protein KdpD; Provisional
 2-54 1.55e-06

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 42.72  E-value: 1.55e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1238243457   2 FDRFykadpSRSRKYG---GSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:PRK10490  831 FDKF-----ARGNKESaipGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLP 881
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 2-54 6.78e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 39.58  E-value: 6.78e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1238243457   2 FDRFYKADPSRSRKyGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:cd16948    58 FDKGFTGENGRNFQ-ESTGMGLYLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 1-54 9.14e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 39.48  E-value: 9.14e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1238243457   1 MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKS----EIGRGTVFLIRLP 54
Cdd:cd16953    53 IFDRFYTERPANEAFGQHSGLGLSISRQIIEAHGGISVAENhnqpGQVIGARFTVQLP 110
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 1-53 4.53e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 37.44  E-value: 4.53e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1238243457   1 MFDRFYKADPSRSrkygGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRL 53
Cdd:cd16976    54 VFDPFFTTKPVGK----GTGLGLSISYGIVEEHGGRLSVANEEGAGARFTFDL 102
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 9-54 5.40e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 37.52  E-value: 5.40e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1238243457   9 DPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:cd16944    63 EPYVTTRPKGTGLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
PRK09303 PRK09303
histidine kinase;
11-54 5.63e-05

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 38.39  E-value: 5.63e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1238243457  11 SRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:PRK09303  333 PRDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
PRK15347 PRK15347
two component system sensor kinase;
2-58 8.63e-05

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 38.08  E-value: 8.63e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1238243457   2 FDRFYKADPSRsrkyGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLPAPDY 58
Cdd:PRK15347  565 FTPFYQADTHS----QGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPLNEY 617
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
18-56 2.57e-04

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 36.52  E-value: 2.57e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1238243457  18 GSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLPAP 56
Cdd:COG4585   212 GGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLA 250
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 1-50 3.17e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 35.51  E-value: 3.17e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1238243457   1 MFDRFYK-ADPSRSRKygGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFL 50
Cdd:cd16945    56 VFERFYSlPRPHSGQK--STGLGLAFVQEVAQLHGGRITLRNRPDGVLAFL 104
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 18-54 3.88e-04

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 35.43  E-value: 3.88e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1238243457  18 GSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:cd16919    80 GTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
13-54 5.57e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 35.76  E-value: 5.57e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1238243457  13 SRKYGGSGLGLAITKSIIDNHNG---TIEVKSEIGRGTVFLIRLP 54
Cdd:COG2972   397 SSKGEGRGIGLRNVRERLKLYYGeeyGLEIESEPGEGTTVTIRIP 441
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 18-59 1.60e-03

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 34.50  E-value: 1.60e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1238243457  18 GSGLGLAITKSIIDNHNGTIEVKSEigRGTVFLIRLPAPDYS 59
Cdd:COG3920   455 RKGLGLRLIRALVRQLGGTLELDRP--EGTRVRITFPLAELA 494
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
14-59 2.79e-03

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 33.79  E-value: 2.79e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1238243457  14 RKYGGSGLGLAITKSIIDNHNG--TIEVKSEiGRGTVFLIRLPAPDYS 59
Cdd:PRK10755  308 SRYGGIGLGLSIVSRITQLHHGqfFLQNRQE-RSGTRAWVWLPKAQNV 354
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
2-39 4.27e-03

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 33.07  E-value: 4.27e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1238243457   2 FDRFYKADPSRSrkygGSGLGLAITKSIIDNHNGTIEV 39
Cdd:PRK10815  429 FDRGQRADTLRP----GQGLGLSVAREITEQYEGKISA 462
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 10-54 5.21e-03

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 32.74  E-value: 5.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1238243457  10 PSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIGRGTVFLIRLP 54
Cdd:COG4192   596 PFTTTKEVGLGLGLSICRSIMQQFGGDLYLASTLERGAMVILEFN 640
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 3-46 9.92e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 31.66  E-value: 9.92e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1238243457   3 DRFYKADPSRSRKyGGSGLGLAITKSIIDNHNGTIEVKSEIGRG 46
Cdd:cd16975    58 ELFYRDDTSRRSG-GHYGMGLYIAKNLVEKHGGSLIIENSQKGG 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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