BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  48 TAKYIYDTLFVNGENSDITIKALDKDWPLHKIYLCQSSYFASMFSGSWKESTLKEITVDIPDQNIDENALKVALGSLYRD 127
Cdd:cd18305     1 TSKYIYQTLFLNGENSDITICALGREWKLHKIYLCQSGYFASMFSGSWKESKETVINLEIPDDNITVEALNVVFGSLYRD 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1274999072 128 DVLIEPARVVSVLAAASLVQLDGLIQQCADVMSEN 162
Cdd:cd18305    81 EIEIKPSRVVSILAAATLLQLDGLIQQCSEVMKET 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  48 TAKYIYDTLFVNGENSDITIKALDKDWPLHKIYLCQSSYFASMFSGSWKESTLKEITVDIPDQNIDENALKVALGSLYRD 127
Cdd:cd18305     1 TSKYIYQTLFLNGENSDITICALGREWKLHKIYLCQSGYFASMFSGSWKESKETVINLEIPDDNITVEALNVVFGSLYRD 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1274999072 128 DVLIEPARVVSVLAAASLVQLDGLIQQCADVMSEN 162
Cdd:cd18305    81 EIEIKPSRVVSILAAATLLQLDGLIQQCSEVMKET 115

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  53 YDTLFVNGENSDITIKALDKDWPLHKIYLC-QSSYFASMFSGSWKESTLKEITVDipdqNIDENALKVALGSLYRDDvLI 131
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAaCSPYFKALFSGQESESSVSEITLD----DVSPEDFEALLEFMYTGK-LI 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1274999072 132 EPARVVSVLAAASLVQLDGLIQQCADVMSENI 163
Cdd:pfam00651  76 SEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

kelch-like protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  50 KYIYDTLFVNgeNSDITIKAldkdwplHKIYLCQSS-YFASMFSGSWKEstlKEITVdipdqNIDENALKVALGSLYRDD 128
Cdd:PHA03098    8 KFCDESIIIV--NGGGIIKV-------HKIILSSSSeYFKKMFKNNFKE---NEINL-----NIDYDSFNEVIKYIYTGK 70

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1274999072 129 VLIEPARVVSVLAAASLVQLDGLIQQCADVMSENI 163
Cdd:PHA03098   71 INITSNNVKDILSIANYLIIDFLINLCINYIIKII 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  48 TAKYIYDTLFVNGENSDITIKALDKDWPLHKIYLCQSSYFASMFSGSWKESTLKEITVDIPDQNIDENALKVALGSLYRD 127
Cdd:cd18305     1 TSKYIYQTLFLNGENSDITICALGREWKLHKIYLCQSGYFASMFSGSWKESKETVINLEIPDDNITVEALNVVFGSLYRD 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1274999072 128 DVLIEPARVVSVLAAASLVQLDGLIQQCADVMSEN 162
Cdd:cd18305    81 EIEIKPSRVVSILAAATLLQLDGLIQQCSEVMKET 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 16 (BTBD16); BTBD16 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  51 YIYDTLFVNGENSDITIKALDKDWPLHKIYLCQSSYFASMFsgswKESTLKeitVDIPDQNIDENALKVALGSLYRDDVL 130
Cdd:cd18291     1 YYHSQKVARSACPDVVLECLGSFWELHSPYLCKSETLAELL----KPVTIS---LNINDPLVTKEAFAVALGNLYNSEVE 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1274999072 131 IEPARVVSVLAAASLVQLDGLIQQCADVMSENISPKTIGAY 171
Cdd:cd18291    74 VNVEDAVGVLAAAALLRFPTLFQKCVKVMISSISSSTVCKF 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  56 LFVNGENSDITIKALDKDWPLHKIYL-CQSSYFASMFSGSWKESTLKEITVdipdQNIDENALKVALGSLYRDDVLIEPA 134
Cdd:cd18238     9 FYENGELCDVTLKVGEKSIHCHRLVLaCVSPYFRAMFTSEMAESKQDSITI----KDIDEEAVELLVDFAYTGKLTLTVD 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1274999072 135 RVVSVLAAASLVQLDGLIQQCADVMSENISP 165
Cdd:cd18238    85 NVQSLLYAASLLQVEEVAKACCEFMKDHLHP 115

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  56 LFVNGENSDITIKALDKDWPLHKIYLC-QSSYFASMFSGSWKESTLKEITVDIpdqnIDENALKVALGSLYRDDV-LIEP 133
Cdd:cd18286    11 LFLNGEDSDITIKVDGKTFKAHRCILCaRSSYFAAMLSGSWAESNSSEITLTG----VSHAAVSFVLLFIYGGVLdLPDD 86

                          90
                  ....*....|....*...
gi 1274999072 134 ARVVSVLAAASLVQLDGL 151
Cdd:cd18286    87 VNLGELLSLADMYGLDGL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  47 CTAKYIYDTLFV---NGENSDITIKALDKDWPLHKIYLCQ-SSYFASMFSGSWKESTLKEITVdipdQNIDENALKVALG 122
Cdd:cd18265     5 CHAERILQVLNAyrrSGTFTDVVLLVDGKDFPCHRATLSAnSAYFRAMFGGHLKESRQAVVEI----QKVSAAAMEVLLD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1274999072 123 SLYRDDVLIEPARVVSVLAAASLVQLDGLIQQCADVMSENISP 165
Cdd:cd18265    81 YMYGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHP 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  64 DITIKALDKDWPLHKIYLCQSS-YFASMFSGSWKESTLKEITVdipdQNIDENALKVALGSLYRDDVLIEPARVVSVLAA 142
Cdd:cd18242    23 DVTLRVEGKEFPAHRIVLAACSdYFCAMFTSEMSEKGKSEVEL----QGLTASTMEILLDFVYTETVHVTVENVQELLPA 98

                          90       100
                  ....*....|....*....|...
gi 1274999072 143 ASLVQLDGLIQQCADVMSENISP 165
Cdd:cd18242    99 ACLLQLKGVKQACCEFLESQLDP 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  63 SDITIKALDKDWPLHKIYLCQSS-YFASMFSGSWKESTLKEITVdipdQNIDENALKVALGSLYRDDVLIEPARVVSVLA 141
Cdd:cd18234     2 CDVILIAGDRRIPAHRLVLSAVSdYFAAMFTNDVREATEEEIKL----KDVDPDALWTLVQYCYTGRLELKEDNVESLLA 77

                          90       100
                  ....*....|....*....|....
gi 1274999072 142 AASLVQLDGLIQQCADVMSENISP 165
Cdd:cd18234    78 TACLLQLSEVVEACCGFLMKQLHP 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  64 DITIKALDKDWPLHKIYLCQSS-YFASMFSGSWKESTLKEITVdipdQNIDENALKVALGSLYRDDVLIEPARVVSVLAA 142
Cdd:cd18247    21 DVTLKVGDQKFSAHRIVLAATIpYFHAMFTHDMVESKQDEITM----QGIEPSALEALINFAYSGRIAIDTSNVQSLLVG 96

                          90
                  ....*....|....*....
gi 1274999072 143 ASLVQLDGLIQQCADVMSE 161
Cdd:cd18247    97 ASFLQLQSVKDACCEFLKE 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  35 KHMNSPQRKKLKCtakyiydtlfvngensDITIKALDKDWPLHKIYLCQ-SSYFASMFSGSWKESTLKEITVdipdQNID 113
Cdd:cd18339    10 KVMNELRSKQLLC----------------DVTIVAEDVEIEAHRVVLAAcSPYFCAMFTGDMSESKAKKIEI----KDVD 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1274999072 114 ENALKVALGSLYRDDVLIEPARVVSVLAAASLVQLDGLIQQCADVMSENISP 165
Cdd:cd18339    70 GQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHP 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  63 SDITIKALDKDWPLHK-IYLCQSSYFASMFSGSWKEStlKEITVDIpdQNIDENALKVALGSLYRDDVLIEPARVVSVLA 141
Cdd:cd18253    19 TDVIICVEGREFPCHRaILSACSSYFRAMFCNDHRES--REMLVEI--NGILAEAMDCFLQYVYTGKVKITTENVQYLFE 94

                          90       100
                  ....*....|....*....|....
gi 1274999072 142 AASLVQLDGLIQQCADVMSENISP 165
Cdd:cd18253    95 TSSLFQISPLRDACAKFLEEQLDP 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  55 TLFVNGENSDITIKALdkdWPLHKIYLCQSS-YFASMFSGSWKESTLKEITVdipdQNIDENALKVALGSLYRDDVLIEP 133
Cdd:cd18273    30 TIEVNGPGSGPGSGRL---FPCNRNVLAAASpYFKSMFTGGLYESKQETVTI----HDVDSESMALIIDYCYTGRVTLSE 102

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1274999072 134 ARVVSVLAAASLVQLDGLIQQCADVMSENIS 164
Cdd:cd18273   103 ANVQRLYAAANMLQLEYVREACASFLARRLD 133

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  64 DITIKALDKDWPLHKIYLCQ-SSYFASMFSGSWKESTLKEITVdipdQNIDENALKVALGSLYRDDVLIEPARVVSVLAA 142
Cdd:cd18261    30 DITLVAEEQKFHAHKAVLAAcSDYFRAMFSLCMVESEADEVNL----HGVTSLGLKQALDFAYTGQILLEPGVIQDVLAA 105

                          90
                  ....*....|....
gi 1274999072 143 ASLVQLDGLIQQCA 156
Cdd:cd18261   106 GSHLQLLELLSLCS 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  64 DITIKALDKDWPLHKIYLCQ-SSYFASMFSGSWKESTLKEITVdipdQNIDENALKVALGSLYRDDVLIEPARVVSVLAA 142
Cdd:cd18336    21 DVLLIAGNLKIPAHRLVLSAvSDYFAAMFTNDVREAKQEEIKM----EGVDPDALKALVHYAYTGVLELKEDTIESLLAA 96

                          90       100
                  ....*....|....*....|...
gi 1274999072 143 ASLVQLDGLIQQCADVMSENISP 165
Cdd:cd18336    97 ACLLQLSQVIDVCCNFLMKQLHP 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  64 DITIKALDKDWPLHKIYLCQSS-YFASMFSGSWKESTLKEitVDIpdQNIDENALKVALGSLYRDDVLIEPARVVSVLAA 142
Cdd:cd18256    22 DVQLQVGMELFSVHRLVLAASSpYFAALFAGGMSESSKDV--VQI--HGVEPDIFHILLDFIYTGVVEVTVSNVQELLVA 97

                          90       100
                  ....*....|....*....|...
gi 1274999072 143 ASLVQLDGLIQQCADVMSENISP 165
Cdd:cd18256    98 ADMLQLTEVVEICCEFLKGQLHP 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  61 ENS--DITIKALDKDWPLHKIYLCQ-SSYFASMFSGSWKESTLKEITVdipdQNIDENALKVALGSLYRDDVLIEPARVV 137
Cdd:cd18236    21 ENSltDVILCVDSQEFSCHRVVLAAaSNYFRAMFCNDLKEKYEEKIII----KGVDAETMQILLDYTYTSKVLITKQNVQ 96

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1274999072 138 SVLAAASLVQLDGLIQQCADVMSENISPKTIG 169
Cdd:cd18236    97 RVLEAASLFQFLRMVDACASFLTEALHPENCV 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  64 DITIKALDKDWPLHKIYLCQSS-YFASMFSGSWKESTLKEITVdipdQNIDENALKVALGSLYRDDVLIEPARVVSVLAA 142
Cdd:cd18255    20 DVTLIADGQRFQAHKVVLASCSdYFRAMFTGGMRESSQDEIEL----KGVSAKGLKHILDFAYTSELTLDLDCIQDVLGA 95

                          90       100
                  ....*....|....*....|..
gi 1274999072 143 ASLVQLDGLIQQCADVMSENIS 164
Cdd:cd18255    96 AVHLQMLPVVELCEEFLKSAMS 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  59 NGENSDITIKALDKDWPLHKIYLCQSS-YFASMFSGSWKESTLKEITVdipdQNIDENALKVALGSLYRDDVLIEPARVV 137
Cdd:cd18237    18 QKTLCDVILIVEGREIKAHRVVLAAAShFFHLMFTSNMTESKSSEVEL----KDAEPDIIELLVEFAYTARISVNSNNVQ 93

                          90       100
                  ....*....|....*....|....*...
gi 1274999072 138 SVLAAASLVQLDGLIQQCADVMSENISP 165
Cdd:cd18237    94 SLLDAANQYQIEPVKKMCVDFLKEQLDA 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  63 SDITIKALDKDWPLHKIYLCQSS-YFASMFSGSWKEStlKEITVDIPDqNIDENALKVALGSLYRDDVLIEPARVVSVLA 141
Cdd:cd18254    23 TDVTLWAGNRSFPCHRAVLAACSrYFEAMFSNGLRES--LDSTVNFHD-SLHPEVLELLLDFAYSSRIIINEENAESLLE 99

                          90       100
                  ....*....|....*....|....
gi 1274999072 142 AASLVQLDGLIQQCADVMSENISP 165
Cdd:cd18254   100 AGDMLQFHDVRDAAAEFLEKNLYP 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  33 DTKHMNSPQRKKLKCTAKYIYDTLFVngenSDITIKALDKDWPLHKIYLCQ-SSYFASMFSGSWKEStlKEITVDIpdQN 111
Cdd:cd18270     1 DERQINTEYAVSLLEQLKFFYEQQLL----TDIVLIVEGTEFPCHKMVLATcSSYFRAMFMSGLSES--KQTHVHL--RN 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1274999072 112 IDENALKVALGSLYRDDVLIEPARVVSVLAAASLVQLDGLIQQCADVMSENISPK 166
Cdd:cd18270    73 VDAATLQIIITYAYTGNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAE 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  56 LFVNGENSDITIKALDKDWPLHKIYLCQSS-YFASMFS-GSWKESTLKEITVDIPDQNID--ENALKValgsLYRDDVLI 131
Cdd:cd18292    11 LYNNEELSDIVLRVGGKVFHAHRLILAKSSdVFRVMLSnDWWSESKQSEIELVEDPECAAvfEKFLRY----LYTGQISV 86

                          90       100
                  ....*....|....*....|....*...
gi 1274999072 132 EPARVVSVLAAASLVQLDGLIQQCADVM 159
Cdd:cd18292    87 NLETALPLLMLADKYNVTDLKQLCVDFM 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  64 DITIKALDKDWPLHKIYLCQ-SSYFASMFSGSWKESTLKEITVDipdqNIDENALKVALGSLYRDDVLIEPARVVSVLAA 142
Cdd:cd18341    29 DCTLKAGDKSLPCHRLILAAcSPYFREYFLSEESEEKKKEVVLD----NVDPNIMDMILKYLYSAEIDLNDGNVQDIFAL 104

                          90       100
                  ....*....|....*....|...
gi 1274999072 143 ASLVQLDGLIQQCADVMSENISP 165
Cdd:cd18341   105 ASRFQIPSVFTVCVTYLQKRLSP 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1274999072  57 FVNGENSDITIKALDKDWPLHKIYL-CQSSYFASMFSGSWKESTLKEITVD 106
Cdd:cd18298     7 FNDPRTSDLKFRVDGKYIYVHKAILkIRCEYFRSMFQSHWNEDDKNVIEID 57

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  64 DITIKALDKDWPLHKIYLCQ-SSYFASMFSGSWKESTLKEITVDipdqNIDENALKVALGSLYRDDVLIEPARVVSVLAA 142
Cdd:cd18269    29 DCVLKIGDKEFPCHRLVLAAcSPYFRAMFLSDLEESKKKEVVLE----DVDPDVMGMILKYLYTSEIDLNDQNVQDIFAL 104

                          90       100
                  ....*....|....*....|...
gi 1274999072 143 ASLVQLDGLIQQCADVMSENISP 165
Cdd:cd18269   105 ASRFQIPSIFTVCVSYLQKRLSL 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  63 SDITIKALDKDWPLHKIYLCQSS-YFASMFSGSWKESTLKEITVdipdQNIDENALKVALGSLYRDDVLIEPARVVSVLA 141
Cdd:cd18250    22 FDVTLCAGGREFPCHRTVLAAASsYFRAMFAGELRESRADRVVL----HGVSAEILGLLLDFSYTGRVTVTQDNVEALLR 97

                          90       100
                  ....*....|....*....|....
gi 1274999072 142 AASLVQLDGLIQQCADVMSENISP 165
Cdd:cd18250    98 AADLFQFPSVKEACCAYLQQRLDV 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  59 NGENSDITIKALDKDWPLHKIYLCQSS-YFASMFSGSWKESTLKEITVDipdqNIDENALKVALGSLYR---DDVLIEPA 134
Cdd:cd18297     9 NPEMSDVTFLVEGRPFYAHKIVLVTASdRFKSMLSSGSTEAQTPVIEIP----DIRYDIFQLMMQYLYTggvESLDVAQD 84

                          90       100       110
                  ....*....|....*....|....*....|
gi 1274999072 135 RVVSVLAAASLVQLDGLIQQCADVMSENIS 164
Cdd:cd18297    85 DALELLRAASFFQLDGLKRHCEILLSQQID 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274999072  75 PLHKIYLCQ-SSYFASMFSGSWKESTlKEItvDIPDqnIDENALKVALGSLYRDDVLIEPARVVSVLAAASLVQLDGLIQ 153
Cdd:cd18282    24 PAHKYVLATgSSVFYAMFYGGLAENK-NEI--EIPD--VEPAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLAR 98