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Conserved domains on  [gi|1277773223|gb|PIT90151|]
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glycosyl transferase family 1 [Candidatus Kuenenbacteria bacterium CG10_big_fil_rev_8_21_14_0_10_36_11]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10133453)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  12691742|10521532|16037492
SCOP:  3001586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 35-376 1.23e-32

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


:

Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 125.73  E-value: 1.23e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223  35 YPAHYQERAKEREFFYRAIKPDVVIGIGWwaDTPQLIREPQKFNILPVPWLL--------------SDGWVANYHSDINA 100
Cdd:cd03801    63 ALLRARRLLRELRPLLRLRKFDVVHAHGL--LAALLAALLALLLGAPLVVTLhgaepgrlllllaaERRLLARAEALLRR 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 101 LPLVFVTSFWVKETYKRDM-VDVKNFEVLHVGYDPKLFRPlpkdqagvrEVRRMFGVKDDEKMILTMGGDTTSKGAQEMI 179
Cdd:cd03801   141 ADAVIAVSEALRDELRALGgIPPEKIVVIPNGVDLERFSP---------PLRRKLGIPPDRPVLLFVGRLSPRKGVDLLL 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 180 VALAKVNQQFKNWKYVCksttsacAHNHHEEELNLMDKLGLPKDKIVYvTDDFSREMVPFLLNAANIYAAPSRIEGFGMI 259
Cdd:cd03801   212 EALAKLLRRGPDVRLVI-------VGGDGPLRAELEELELGLGDRVRF-LGFVPDEELPALYAAADVFVLPSRYEGFGLV 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 260 QVEAMACGTPVISIDAMGPKDTIVHGETGFLAKVGgtveltdewvneemgfdeafkvkfekpkifayraDIDELADYTLK 339
Cdd:cd03801   284 VLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPPD----------------------------------DVEALADALLR 329

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1277773223 340 LLTDEKLAREMGEKAARHALENFDYKKLARHCLNILQ 376
Cdd:cd03801   330 LLADPELRARLGRAARERVAERFSWERVAERLLDLYR 366
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 35-376 1.23e-32

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 125.73  E-value: 1.23e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223  35 YPAHYQERAKEREFFYRAIKPDVVIGIGWwaDTPQLIREPQKFNILPVPWLL--------------SDGWVANYHSDINA 100
Cdd:cd03801    63 ALLRARRLLRELRPLLRLRKFDVVHAHGL--LAALLAALLALLLGAPLVVTLhgaepgrlllllaaERRLLARAEALLRR 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 101 LPLVFVTSFWVKETYKRDM-VDVKNFEVLHVGYDPKLFRPlpkdqagvrEVRRMFGVKDDEKMILTMGGDTTSKGAQEMI 179
Cdd:cd03801   141 ADAVIAVSEALRDELRALGgIPPEKIVVIPNGVDLERFSP---------PLRRKLGIPPDRPVLLFVGRLSPRKGVDLLL 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 180 VALAKVNQQFKNWKYVCksttsacAHNHHEEELNLMDKLGLPKDKIVYvTDDFSREMVPFLLNAANIYAAPSRIEGFGMI 259
Cdd:cd03801   212 EALAKLLRRGPDVRLVI-------VGGDGPLRAELEELELGLGDRVRF-LGFVPDEELPALYAAADVFVLPSRYEGFGLV 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 260 QVEAMACGTPVISIDAMGPKDTIVHGETGFLAKVGgtveltdewvneemgfdeafkvkfekpkifayraDIDELADYTLK 339
Cdd:cd03801   284 VLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPPD----------------------------------DVEALADALLR 329

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1277773223 340 LLTDEKLAREMGEKAARHALENFDYKKLARHCLNILQ 376
Cdd:cd03801   330 LLADPELRARLGRAARERVAERFSWERVAERLLDLYR 366
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 240-377 5.90e-25

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 98.14  E-value: 5.90e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 240 LLNAANIYAAPSRIEGFGMIQVEAMACGTPVISIDAMGPKDTIVHGETGFLAKVGgtveltdewvneemgfdeafkvkfe 319
Cdd:COG0438    17 LLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPG------------------------- 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1277773223 320 kpkifayraDIDELADYTLKLLTDEKLAREMGEKAARHALENFDYKKLARHCLNILQE 377
Cdd:COG0438    72 ---------DPEALAEAILRLLEDPELRRRLGEAARERAEERFSWEAIAERLLALYEE 120
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 159-357 7.49e-25

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 98.89  E-value: 7.49e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 159 DEKMILTMGGDTTSKGAQEMIVALAKVNQQFKNWKYVcksttsACAHNHHEEEL-NLMDKLGLPKDkiVYVTDDFSREMV 237
Cdd:pfam00534   1 KKKIILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLV------IAGDGEEEKRLkKLAEKLGLGDN--VIFLGFVSDEDL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 238 PFLLNAANIYAAPSRIEGFGMIQVEAMACGTPVISIDAMGPKDTIVHGETGFLAKVGgtveltdewvneemgfdeafkvk 317
Cdd:pfam00534  73 PELLKIADVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPN----------------------- 129

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1277773223 318 fekpkifayraDIDELADYTLKLLTDEKLAREMGEKAARH 357
Cdd:pfam00534 130 -----------NAEALAEAIDKLLEDEELRERLGENARKR 158
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 244-373 5.72e-08

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 54.33  E-value: 5.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 244 ANIYAAPSRIEGFGMIQVEAMACGTPVISIDAMGPKDTI---VHGETGFLAKVGgtveltdewvneemgfdeafkvkfek 320
Cdd:PLN02871  332 GDVFVMPSESETLGFVVLEAMASGVPVVAARAGGIPDIIppdQEGKTGFLYTPG-------------------------- 385

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1277773223 321 pkifayraDIDELADYTLKLLTDEKLAREMGeKAARHALENFDYKKLARHCLN 373
Cdd:PLN02871  386 --------DVDDCVEKLETLLADPELRERMG-AAAREEVEKWDWRAATRKLRN 429
stp2 TIGR03088
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ...
 234-301 1.28e-07

sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.


Pssm-ID: 132132 [Multi-domain]  Cd Length: 374  Bit Score: 53.19  E-value: 1.28e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1277773223 234 REMVPFLLNAANIYAAPSRIEGFGMIQVEAMACGTPVISIDAMGPKDTIVHGETGFLAKVGGTVELTD 301
Cdd:TIGR03088 263 RDDVPALMQALDLFVLPSLAEGISNTILEAMASGLPVIATAVGGNPELVQHGVTGALVPPGDAVALAR 330
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 35-376 1.23e-32

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 125.73  E-value: 1.23e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223  35 YPAHYQERAKEREFFYRAIKPDVVIGIGWwaDTPQLIREPQKFNILPVPWLL--------------SDGWVANYHSDINA 100
Cdd:cd03801    63 ALLRARRLLRELRPLLRLRKFDVVHAHGL--LAALLAALLALLLGAPLVVTLhgaepgrlllllaaERRLLARAEALLRR 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 101 LPLVFVTSFWVKETYKRDM-VDVKNFEVLHVGYDPKLFRPlpkdqagvrEVRRMFGVKDDEKMILTMGGDTTSKGAQEMI 179
Cdd:cd03801   141 ADAVIAVSEALRDELRALGgIPPEKIVVIPNGVDLERFSP---------PLRRKLGIPPDRPVLLFVGRLSPRKGVDLLL 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 180 VALAKVNQQFKNWKYVCksttsacAHNHHEEELNLMDKLGLPKDKIVYvTDDFSREMVPFLLNAANIYAAPSRIEGFGMI 259
Cdd:cd03801   212 EALAKLLRRGPDVRLVI-------VGGDGPLRAELEELELGLGDRVRF-LGFVPDEELPALYAAADVFVLPSRYEGFGLV 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 260 QVEAMACGTPVISIDAMGPKDTIVHGETGFLAKVGgtveltdewvneemgfdeafkvkfekpkifayraDIDELADYTLK 339
Cdd:cd03801   284 VLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPPD----------------------------------DVEALADALLR 329

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1277773223 340 LLTDEKLAREMGEKAARHALENFDYKKLARHCLNILQ 376
Cdd:cd03801   330 LLADPELRARLGRAARERVAERFSWERVAERLLDLYR 366
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 240-377 5.90e-25

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 98.14  E-value: 5.90e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 240 LLNAANIYAAPSRIEGFGMIQVEAMACGTPVISIDAMGPKDTIVHGETGFLAKVGgtveltdewvneemgfdeafkvkfe 319
Cdd:COG0438    17 LLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPG------------------------- 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1277773223 320 kpkifayraDIDELADYTLKLLTDEKLAREMGEKAARHALENFDYKKLARHCLNILQE 377
Cdd:COG0438    72 ---------DPEALAEAILRLLEDPELRRRLGEAARERAEERFSWEAIAERLLALYEE 120
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 159-357 7.49e-25

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 98.89  E-value: 7.49e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 159 DEKMILTMGGDTTSKGAQEMIVALAKVNQQFKNWKYVcksttsACAHNHHEEEL-NLMDKLGLPKDkiVYVTDDFSREMV 237
Cdd:pfam00534   1 KKKIILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLV------IAGDGEEEKRLkKLAEKLGLGDN--VIFLGFVSDEDL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 238 PFLLNAANIYAAPSRIEGFGMIQVEAMACGTPVISIDAMGPKDTIVHGETGFLAKVGgtveltdewvneemgfdeafkvk 317
Cdd:pfam00534  73 PELLKIADVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPN----------------------- 129

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1277773223 318 fekpkifayraDIDELADYTLKLLTDEKLAREMGEKAARH 357
Cdd:pfam00534 130 -----------NAEALAEAIDKLLEDEELRERLGENARKR 158
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 1-377 2.04e-24

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 102.80  E-value: 2.04e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223   1 MKLLILYEHPASlGSMSTQGQLLYQGLKENGIECYPAHYqeRAKEREFFYRAIKPDVV---IGIGWWADTPQLIREPQKf 77
Cdd:cd03825     1 MKVLHINTVDLS-GGAARAAYRLHQALLAYGIDSTMLVG--RKKNLISKPEFIEADIIhlhWIHGGYLSLKALFKLLRR- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223  78 niLPVPWLLSDGWVAN----YHSDIN-----------------------------------ALPLVFVT-SFWVKETYKR 117
Cdd:cd03825    77 --KPVVWTLHDMWPFTggchYPMECEgwktgcgncpnlnsyppakkdlsrqlfrrkrealaKKRLTIVApSRWLADMVRR 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 118 DMVDvKNFEVLHV--GYDPKLFRPLPKdqagvREVRRMFGVKDDEKMIL--TMGGDTTSKGAQEMIVALAKVNQQfknwk 193
Cdd:cd03825   155 SPLL-KGLPVVVIpnGIDTEIFAPVDK-----AKARKRLGIPQDKKVILfgAESVTKPRKGFDELIEALKLLATK----- 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 194 yvcKSTTSACAHNHHEEELnlmdKLGLPKDKIVYVTDDfsREMVPfLLNAANIYAAPSRIEGFGMIQVEAMACGTPVISI 273
Cdd:cd03825   224 ---DDLLLVVFGKNDPQIV----ILPFDIISLGYIDDD--EQLVD-IYSAADLFVHPSLADNLPNTLLEAMACGTPVVAF 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 274 DAMGPKDTIVHGETGFLAKVGgtveltdewvneemgfdeafkvkfekpkifayraDIDELADYTLKLLTDEKLAREMGEK 353
Cdd:cd03825   294 DTGGSPEIVQHGVTGYLVPPG----------------------------------DVQALAEAIEWLLANPKERESLGER 339

                         410       420
                  ....*....|....*....|....
gi 1277773223 354 AARHALENFDYKKLARHCLNILQE 377
Cdd:cd03825   340 ARALAENHFDQRVQAQRYLELYKD 363
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 120-369 2.26e-24

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 103.09  E-value: 2.26e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 120 VDVKNFEVLHVGYDPKLFRPLPKDQAgvreVRRMFGVKDDEKMILTMGGDTTSKGAQEMIVALAKVNqqfknwkyvckst 199
Cdd:cd03800   184 ADPSRINVVPPGVDLERFFPVDRAEA----RRARLLLPPDKPVVLALGRLDPRKGIDTLVRAFAQLP------------- 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 200 tsacahnHHEEELNLMDKLG-----LPKD--------KIVYVTDDF------SREMVPFLLNAANIYAAPSRIEGFGMIQ 260
Cdd:cd03800   247 -------ELRELANLVLVGGpsddpLSMDreelaelaEELGLIDRVrfpgrvSRDDLPELYRAADVFVVPSLYEPFGLTA 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 261 VEAMACGTPVISIDAMGPKDTIVHGETGFLakVGGTveltdewvneemgfdeafkvkfekpkifayraDIDELADYTLKL 340
Cdd:cd03800   320 IEAMACGTPVVATAVGGLQDIVRDGRTGLL--VDPH--------------------------------DPEALAAALRRL 365

                         250       260
                  ....*....|....*....|....*....
gi 1277773223 341 LTDEKLAREMGEKAARHALENFDYKKLAR 369
Cdd:cd03800   366 LDDPALWQRLSRAGLERARAHYTWESVAD 394
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 103-377 1.90e-21

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 94.37  E-value: 1.90e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 103 LVFVTSFwVKETYKRDMVDVKNFEVLHVGYDPKLFRPLPkdqagvrevrRMFGVKDDEKMILTMGGDTTSKGAQEMIVAL 182
Cdd:cd03798   154 VIAVSKA-LAEELVALGVPRDRVDVIPNGVDPARFQPED----------RGLGLPLDAFVILFVGRLIPRKGIDLLLEAF 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 183 AKVNQQFKNWKYV---CKSTTSACAHNHheEELNLMDKlglpkdkiVYVTDDFSREMVPFLLNAANIYAAPSRIEGFGMI 259
Cdd:cd03798   223 ARLAKARPDVVLLivgDGPLREALRALA--EDLGLGDR--------VTFTGRLPHEQVPAYYRACDVFVLPSRHEGFGLV 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 260 QVEAMACGTPVISIDAMGPKDTIVHGETGFLAKVGgtveltdewvneemgfdeafkvkfekpkifayraDIDELADYTLK 339
Cdd:cd03798   293 LLEAMACGLPVVATDVGGIPEVVGDPETGLLVPPG----------------------------------DADALAAALRR 338

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1277773223 340 LLtDEKLAREMGEKAARHALENFDYKKLARHCLNILQE 377
Cdd:cd03798   339 AL-AEPYLRELGEAARARVAERFSWVKAADRIAAAYRD 375
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 49-362 1.78e-20

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 91.53  E-value: 1.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223  49 FYRAIKPDVVIGIGwwadtpqlirePQKFNILPVpWLLSDGWVANYHSDINALPLVFVTSFWVKETYKR-DMV------D 121
Cdd:cd03820    82 YLKNNKPDVVISFR-----------TSLLTFLAL-IGLKSKLIVWEHNNYEAYNKGLRRLLLRRLLYKRaDKIvvlteaD 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 122 VKNFEVL---HVGYDPKLFRPLPKDQAGVREvrrmfgvkddEKMILTMGGDTTSKGAQEMIVALAKVNQQFKNWKYV--- 195
Cdd:cd03820   150 KLKKYKQpnsNVVVIPNPLSFPSEEPSTNLK----------SKRILAVGRLTYQKGFDLLIEAWALIAKKHPDWKLRiyg 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 196 ---CKsttsacahnhhEEELNLMDKLGLpKDKIVYVTddFSREMVPFLLNAAnIYAAPSRIEGFGMIQVEAMACGTPVIS 272
Cdd:cd03820   220 dgpER-----------EELEKLIDKLGL-EDRVKLLG--PTKNIAEEYANSS-IFVLSSRYEGFPMVLLEAMAYGLPIIS 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 273 IDAM-GPKDTIVHGETGFLAKVGgtveltdewvneemgfdeafkvkfekpkifayraDIDELADYTLKLLTDEKLAREMG 351
Cdd:cd03820   285 FDCPtGPSEIIEDGENGLLVPNG----------------------------------DVDALAEALLRLMEDEELRKKMG 330

                         330
                  ....*....|.
gi 1277773223 352 eKAARHALENF 362
Cdd:cd03820   331 -KNARKNAERF 340
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 106-366 2.59e-19

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 88.18  E-value: 2.59e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 106 VTSFWVKETYkrDMVDVKN-FEVLHVGYDPKLFRPLPKDqagvrEVRRMFGVKDDEKMILTMGGDTTSKGAQEMIVALAK 184
Cdd:cd04962   148 VSSSLRQETY--ELFDVDKdIEVIHNFIDEDVFKRKPAG-----ALKRRLLAPPDEKVVIHVSNFRPVKRIDDVVRVFAR 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 185 VNQQFKNwKYVC------KSTTsacahnhheeeLNLMDKLGLPKDkiVYVTDDFSRemVPFLLNAANIYAAPSRIEGFGM 258
Cdd:cd04962   221 VRRKIPA-KLLLvgdgpeRVPA-----------EELARELGVEDR--VLFLGKQDD--VEELLSIADLFLLPSEKESFGL 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 259 IQVEAMACGTPVISIDAMGPKDTIVHGETGFLAKVGgtveltdewvneemgfdeafkvkfekpkifayraDIDELADYTL 338
Cdd:cd04962   285 AALEAMACGVPVVSSNAGGIPEVVKHGETGFLSDVG----------------------------------DVDAMAKSAL 330

                         250       260
                  ....*....|....*....|....*...
gi 1277773223 339 KLLTDEKLAREMGEKAARHALENFDYKK 366
Cdd:cd04962   331 SILEDDELYNRMGRAARKRAAERFDPER 358
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 214-363 3.80e-19

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 87.65  E-value: 3.80e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 214 LMDKLGLpKDKIVYV--TDDfsremVPFLLNAANIYAAPSRIEGFGMIQVEAMACGTPVISIDAMGPKDTIVHGETGFLA 291
Cdd:cd03808   238 LIEKLGL-EGRIEFLgfRSD-----VPELLAESDVFVLPSYREGLPRSLLEAMAAGRPVITTDVPGCRELVIDGVNGFLV 311

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1277773223 292 KVGgtveltdewvneemgfdeafkvkfekpkifayraDIDELADYTLKLLTDEKLAREMGEKAARHALENFD 363
Cdd:cd03808   312 PPG----------------------------------DVEALADAIEKLIEDPELRKEMGEAARKRVEEKFD 349
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 2-290 1.42e-17

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 81.30  E-value: 1.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223   2 KLLILYEHPASLGSMSTQGQLLYQGLKENGIECYPAHYQERAKEREFFY-RAIKPDVVIGIGWWADTPQLIREPQKFNIl 80
Cdd:cd01635     1 ILLVTGEYPPLRGGLELHVRALARALAALGHEVTVLALLLLALRRILKKlLELKPDVVHAHSPHAAALAALLAARLLGI- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223  81 pvpwllsdGWVANYHSdinalPLVFVTSFWVKETYKRDMVDVKNFEVLHVGydpklfrplpkdqagvrevrRMFGvkdde 160
Cdd:cd01635    80 --------PIVVTVHG-----PDSLESTRSELLALARLLVSLPLADKVSVG--------------------RLVP----- 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 161 kmiltmggdttSKGAQEMIVALAKVNQQFKNWKYVcksttsACAHNHHEEELNLMDKLGLPKDKIVYVTDDFSREMVPFL 240
Cdd:cd01635   122 -----------EKGIDLLLEALALLKARLPDLVLV------LVGGGGEREEEEALAAALGLLERVVIIGGLVDDEVLELL 184

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1277773223 241 LNAANIYAAPSRIEGFGMIQVEAMACGTPVISIDAMGPKDTIVHGETGFL 290
Cdd:cd01635   185 LAAADVFVLPSRSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGLL 234
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 111-335 1.82e-17

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 82.71  E-value: 1.82e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 111 VKETYKRDMVDvKNFEVLHVGYDPKLFRPLPKDqagvrEVRRMFGVKDDEKMILTMGGDTTSKGAQEMIVALAKVNQQfK 190
Cdd:cd03817   158 IKDTLREYGVK-GPIEVIPNGIDLDKFEKPLNT-----EERRKLGLPPDEPILLYVGRLAKEKNIDFLLRAFAELKKE-P 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 191 NWKYVCKSTTSAcahnhhEEEL-NLMDKLGLPKDKIVyvTDDFSREMVPFLLNAANIYAAPSRIEGFGMIQVEAMACGTP 269
Cdd:cd03817   231 NIKLVIVGDGPE------REELkELARELGLADKVIF--TGFVPREELPEYYKAADLFVFASTTETQGLVYLEAMAAGLP 302

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1277773223 270 VISIDAMGPKDTIVHGETGFLAKVGgtVELTDEWVNEEMGFDEAFKVKFEKPKIFAYRADIDELAD 335
Cdd:cd03817   303 VVAAKDPAASELVEDGENGFLFEPN--DETLAEKLLHLRENLELLRKLSKNAEISAREFAFAKSVE 366
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 151-369 1.35e-16

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 80.49  E-value: 1.35e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 151 RRMFGVKDDEKMILTMGGDTTSKGAQEMIVALAKVNQQFKNWKYVCKSTTSacahNHHEEELNLMDKLGLpKDKIVYvTD 230
Cdd:cd03821   195 RRKHNGLEDRRIILFLGRIHPKKGLDLLIRAARKLAEQGRDWHLVIAGPDD----GAYPAFLQLQSSLGL-GDRVTF-TG 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 231 DFSREMVPFLLNAANIYAAPSRIEGFGMIQVEAMACGTPVISIDAMGPKDTIVHGetgflakVGGTVELTDEwvneemgf 310
Cdd:cd03821   269 PLYGEAKWALYASADLFVLPSYSENFGNVVAEALACGLPVVITDKCGLSELVEAG-------CGVVVDPNVS-------- 333

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1277773223 311 deafkvkfekpkifAYRADIDELadytLKLLTDEKLAREMGEKaARHALENFDYKKLAR 369
Cdd:cd03821   334 --------------SLAEALAEA----LRDPADRKRLGEMARR-ARQVEENFSWEAVAG 373
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 111-290 1.63e-16

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 80.05  E-value: 1.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 111 VKETYKRDMVDVKNFEVLHVGYDPKLFRPlpkDQAGVREVRRMFGVKDDEKMILTMGGDTTSKGAQEMIVALAKVNQQFK 190
Cdd:cd03807   144 VAEFHQEQGYAKNKIVVIYNGIDLFKLSP---DDASRARARRRLGLAEDRRVIGIVGRLHPVKDHSDLLRAAALLVETHP 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 191 NWKYVCksTTSACAHNHHEEELnlmDKLGLPKDkiVYVTDDfsREMVPFLLNAANIYAAPSRIEGFGMIQVEAMACGTPV 270
Cdd:cd03807   221 DLRLLL--VGRGPERPNLERLL---LELGLEDR--VHLLGE--RSDVPALLPAMDIFVLSSRTEGFPNALLEAMACGLPV 291

                         170       180
                  ....*....|....*....|
gi 1277773223 271 ISIDAMGPKDTIVHGeTGFL 290
Cdd:cd03807   292 VATDVGGAAELVDDG-TGFL 310
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 127-302 4.26e-16

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 78.55  E-value: 4.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 127 VLHVGYDPKLFRPlpkdqAGVREVRRMFGVKDDEKMILTMGGDTTSKGAQEMIVALAKVNQQfKNWKYVCksttsaCAHN 206
Cdd:cd03819   154 VIPNGVDTDRFPP-----EAEAEERAQLGLPEGKPVVGYVGRLSPEKGWLLLVDAAAELKDE-PDFRLLV------AGDG 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 207 HHEEEL-NLMDKLGLpKDKIVYVtdDFsREMVPFLLNAANIYAAPSRIEGFGMIQVEAMACGTPVISIDAMGPKDTIVHG 285
Cdd:cd03819   222 PERDEIrRLVERLGL-RDRVTFT--GF-REDVPAALAASDVVVLPSLHEEFGRVALEAMACGTPVVATDVGGAREIVVHG 297

                         170
                  ....*....|....*..
gi 1277773223 286 ETGFLAKVGGTVELTDE 302
Cdd:cd03819   298 RTGLLVPPGDAEALADA 314
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
 179-369 6.84e-16

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 78.40  E-value: 6.84e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 179 IVALAKVNQQFKNWK----YVCKSTTSACAHN--HHEEELNLMDKLGLPKDKIVY---VTDDFSRemvpFLLNAAN--IY 247
Cdd:cd03805   230 IEAFAKLKQKLPEFEnvrlVIAGGYDPRVAENveYLEELQRLAEELLNVEDQVLFlrsISDSQKE----QLLSSALalLY 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 248 AaPSRiEGFGMIQVEAMACGTPVISIDAMGPKDTIVHGETGFLakvggtVELTDEwvneemgfdeafkvkfekpkifayr 327
Cdd:cd03805   306 T-PSN-EHFGIVPLEAMYAGKPVIACNSGGPLETVVEGVTGFL------CEPTPE------------------------- 352

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1277773223 328 adidELADYTLKLLTDEKLAREMGEKAARHALENFDYKKLAR 369
Cdd:cd03805   353 ----AFAEAMLKLANDPDLADRMGAAGRKRVKEKFSREAFAE 390
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
240-301 8.63e-16

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 73.31  E-value: 8.63e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1277773223 240 LLNAANIYAAPSRIEGFGMIQVEAMACGTPVISIDAMGPKDtIVHGETGFLAKVGGTVELTD 301
Cdd:pfam13692  70 LLAAADVFVLPSLYEGFGLKLLEAMAAGLPVVATDVGGIPE-LVDGENGLLVPPGDPEALAE 130
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 49-294 1.04e-15

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 77.40  E-value: 1.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223  49 FYRAIKPDVVIGIGWWA----------DTPQLIREPQKFNILPVPWLLSDGWVANYHsdiNALPLVFVTSfWVKETYKRD 118
Cdd:cd03811    78 ILKRAKPDVVISFLGFAtyivaklaaaRSKVIAWIHSSLSKLYYLKKKLLLKLKLYK---KADKIVCVSK-GIKEDLIRL 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 119 MVDVK-NFEVLHVGYDPKLFRPLPKDQAgvrevrrmFGVKDDEKMILTMGGDTTSKGAQEMIVALAKVNQQFKNWKYVCk 197
Cdd:cd03811   154 GPSPPeKIEVIYNPIDIDRIRALAKEPI--------LNEPEDGPVILAVGRLDPQKGHDLLIEAFAKLRKKYPDVKLVI- 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 198 sttsACAHNHHEEELNLMDKLGLpKDKIV---YVTDdfsremvPF-LLNAANIYAAPSRIEGFGMIQVEAMACGTPVISI 273
Cdd:cd03811   225 ----LGDGPLREELEKLAKELGL-AERVIflgFQSN-------PYpYLKKADLFVLSSRYEGFPNVLLEAMALGTPVVST 292

                         250       260
                  ....*....|....*....|.
gi 1277773223 274 DAMGPKDTIVHGETGFLAKVG 294
Cdd:cd03811   293 DCPGPREILDDGENGLLVPDG 313
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 120-369 5.76e-15

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 75.48  E-value: 5.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 120 VDVKNFEVLHVGYDPkLFRPLPKDQagvrevRRMFGVKDDEKMILTMGGDTTSKGAQEMIVALAKVNQQFKNWKYVCkst 199
Cdd:cd03809   159 VPPEKIVVIPLGVDP-SFFPPESAA------VLIAKYLLPEPYFLYVGTLEPRKNHERLLKAFALLKKQGGDLKLVI--- 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 200 tsACA-HNHHEEELNLMDKLGLPKDkiVYVTDDFSREMVPFLLNAANIYAAPSRIEGFGMIQVEAMACGTPVI--SIDAM 276
Cdd:cd03809   229 --VGGkGWEDEELLDLVKKLGLGGR--VRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIasNISVL 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 277 gpkDTIVhGETGFLakvggtveltdewvneemgFDEafkvkfekpkifayrADIDELADYTLKLLTDEKLAREMGEKAAR 356
Cdd:cd03809   305 ---PEVA-GDAALY-------------------FDP---------------LDPESIADAILRLLEDPSLREELIRKGLE 346

                         250
                  ....*....|...
gi 1277773223 357 HAlENFDYKKLAR 369
Cdd:cd03809   347 RA-KKFSWEKTAE 358
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 126-363 2.99e-14

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 73.26  E-value: 2.99e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 126 EVLHVGYDPKLFRPLPkdqagvrevrrmfgVKDDEKMILTMGGDTTSKGAQEMIVALAKVNQQFKNWKYVCKSTTSacah 205
Cdd:cd05844   169 HVHYIGIDPAKFAPRD--------------PAERAPTILFVGRLVEKKGCDVLIEAFRRLAARHPTARLVIAGDGP---- 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 206 nhheeELNLMDKLGLPKDKIVYvTDDFSREMVPFLLNAANIYAAPSRI------EGFGMIQVEAMACGTPVISIDAMGPK 279
Cdd:cd05844   231 -----LRPALQALAAALGRVRF-LGALPHAEVQDWMRRAEIFCLPSVTaasgdsEGLGIVLLEAAACGVPVVSSRHGGIP 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 280 DTIVHGETGFLAKVGgtveltdewvneemgfdeafkvkfekpkifayraDIDELADYTLKLLTDEKLAREMGEKAARHAL 359
Cdd:cd05844   305 EAILDGETGFLVPEG----------------------------------DVDALADALQALLADRALADRMGGAARAFVC 350


                  ....
gi 1277773223 360 ENFD 363
Cdd:cd05844   351 EQFD 354
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 120-369 1.49e-13

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 71.22  E-value: 1.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 120 VDVKNFEVLHVGYDPKLFRPLPKDQAGVREvrrmfgvKDDEKMILTMGGDTTSKGAQEMIVALAKVNQQFKNWKYVCkst 199
Cdd:cd03794   183 VPKEKIIVIPNWADLEEFKPPPKDELRKKL-------GLDDKFVVVYAGNIGKAQGLETLLEAAERLKRRPDIRFLF--- 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 200 tsaCAHNHHEEELNLMDKLGLPKDkiVYVTDDFSREMVPFLLNAANI------------YAAPSRIegfgmiqVEAMACG 267
Cdd:cd03794   253 ---VGDGDEKERLKELAKARGLDN--VTFLGRVPKEEVPELLSAADVglvplkdnpanrGSSPSKL-------FEYMAAG 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 268 TPVISIDAMGPKDTIVHGETGFLAKVGgtveltdewvneemgfdeafkvkfekpkifayraDIDELADYTLKLLTDEKLA 347
Cdd:cd03794   321 KPILASDDGGSDLAVEINGCGLVVEPG----------------------------------DPEALADAILELLDDPELR 366

                         250       260
                  ....*....|....*....|..
gi 1277773223 348 REMGEKAARHALENFDYKKLAR 369
Cdd:cd03794   367 RAMGENGRELAEEKFSREKLAD 388
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 244-360 6.77e-12

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 66.16  E-value: 6.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 244 ANIYAA------PSRIEGFGMIQVEAMACGTPVISIDAMGPKDTIVHGETGFLAKVGgtveltdewvneemgfdeafkvk 317
Cdd:cd03814   262 ARAYASadvfvfPSRTETFGLVVLEAMASGLPVVAADAGGPRDIVRPGGTGALVEPG----------------------- 318

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1277773223 318 fekpkifayraDIDELADYTLKLLTDEKLAREMGEKAARHALE 360
Cdd:cd03814   319 -----------DAAAFAAALRALLEDPELRRRMAARARAEAER 350
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 232-362 7.28e-12

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 66.14  E-value: 7.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 232 FSREMVPFLLNAANIYAAPS--RIEGFGMIQVEAMACGTPVIS--IDAMGPkDTIVHGETGFlakvggTVeltdewvnee 307
Cdd:cd03795   250 VDDEEKVIYLHLCDVFVFPSvlRSEAFGIVLLEAMMCGKPVIStnIGTGVP-YVNNNGETGL------VV---------- 312

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1277773223 308 mgfdeafkvkfeKPKifayraDIDELADYTLKLLTDEKLAREMGEKAARHALENF 362
Cdd:cd03795   313 ------------PPK------DPDALAEAIDKLLSDEELRESYGENAKKRFEELF 349
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 121-331 8.64e-12

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 65.93  E-value: 8.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 121 DVKNFEVLHvGYDPKLFRplpKDQAGVREVRRMFGVKDDEKMILTMGGDTTSKGAQEMIVALAKVNQQFKNWKYVCKSTT 200
Cdd:cd04951   153 KNKSVPVYN-GIDLNKFK---KDINVRLKIRNKLNLKNDEFVILNVGRLTEAKDYPNLLLAISELILSKNDFKLLIAGDG 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 201 SAcahnhHEEELNLMDKLGLpKDKIVYVTddfSREMVPFLLNAANIYAAPSRIEGFGMIQVEAMACGTPVISIDAMGPKD 280
Cdd:cd04951   229 PL-----RNELERLICNLNL-VDRVILLG---QISNISEYYNAADLFVLSSEWEGFGLVVAEAMACERPVVATDAGGVAE 299

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1277773223 281 tiVHGETGFLAKVGGTVELTDEwVNEEMGFD-EAFKVKFEKPKIFAYRADID 331
Cdd:cd04951   300 --VVGDHNYVVPVSDPQLLAEK-IKEIFDMSdEERDILGNKNEYIAKNFSIN 348
GT4_WbaZ-like cd03804
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 ...
 254-317 3.50e-09

mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity.


Pssm-ID: 340833 [Multi-domain]  Cd Length: 356  Bit Score: 57.68  E-value: 3.50e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1277773223 254 EGFGMIQVEAMACGTPVISIDAMGPKDTIVHGETGFLAKVgGTVELTDEWVNEEMGFDEAFKVK 317
Cdd:cd03804   275 EDFGIVPVEAQACGTPVIAFGKGGALETVRPGPTGILFGE-QTVESLKAAVEEFEQNFDRFKPQ 337
COG4641 COG4641
Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];
18-377 8.54e-09

Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443679 [Multi-domain]  Cd Length: 303  Bit Score: 56.09  E-value: 8.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223  18 TQGQLLYQGLKENGIECY---PAHYQERAKEREFFYRAIKPDVVIGIGWwadtPQLIREPQKFNILPVPWLLSDGWvaNY 94
Cdd:COG4641    10 TYYRGLLRALAALGHEVTflePDDPWHDPLYAAELLDAFRPDLVLVISG----VELVAALRARGIPTVFWDTDDPV--TL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223  95 HSDINALP---LVFVTSFWVKETYKRdmVDVKNFEVLHVGYDPKLFRPLPKDQAGVREVrrMF-GVKDDEKmiltmggdt 170
Cdd:COG4641    84 DRFRELLPlydLVFTFDGDCVEEYRA--LGARRVFYLPFAADPELHRPVPPEARFRYDV--AFvGNYYPDR--------- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 171 tskgaQEMIVALAKVNQQFK------NWkyvcksttsacahnhheeelnlmDKLGLPKDkiVYVTDDFSREMVPFLLNAA 244
Cdd:COG4641   151 -----RARLEELLLAPAGLRlkiygpGW-----------------------PKLALPAN--VRRGGHLPGEEHPAAYASS 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 245 ----NIyaaPSRIEGFGMIQV---EAMACGTPVIsidamgpkdtivhgetgflakvggtvelTDEWvnEEMgfDEAFKvk 317
Cdd:COG4641   201 kitlNV---NRMAASPDSPTRrtfEAAACGAFLL----------------------------SDPW--EGL--EELFE-- 243

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 318 fEKPKIFAYRaDIDELADYTLKLLTDEKLAREMGEKAARHALENFDYKKLARHCLNILQE 377
Cdd:COG4641   244 -PGEEVLVFR-DGEELAEKLRYLLADPEERRAIAEAGRRRVLAEHTYAHRARELLAILEE 301
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 254-291 1.26e-08

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 55.76  E-value: 1.26e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1277773223 254 EGFGMIQVEAMACGTPVISIDAMGPKDTIVHGETGFLA 291
Cdd:cd03802   251 EPFGLVMIEAMACGTPVIAYRRGGLPEVIQHGETGFLV 288
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 240-363 1.67e-08

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 55.79  E-value: 1.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 240 LLNAANIYAAPSRIEGFGMIQVEAMACGTPVISIDAMGPKDTIVHGETGFLAKVGgtveltdewvneemgfdeafkvkfe 319
Cdd:cd03792   276 LQRAATVVLQLSTREGFGLTVSEALWKGKPVIATPAGGIPLQVIDGETGFLVNSV------------------------- 330

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1277773223 320 kpkifayradiDELADYTLKLLTDEKLAREMGEKAARHALENFD 363
Cdd:cd03792   331 -----------EGAAVRILRLLTDPELRRKMGLAAREHVRDNFL 363
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 244-373 5.72e-08

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 54.33  E-value: 5.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 244 ANIYAAPSRIEGFGMIQVEAMACGTPVISIDAMGPKDTI---VHGETGFLAKVGgtveltdewvneemgfdeafkvkfek 320
Cdd:PLN02871  332 GDVFVMPSESETLGFVVLEAMASGVPVVAARAGGIPDIIppdQEGKTGFLYTPG-------------------------- 385

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1277773223 321 pkifayraDIDELADYTLKLLTDEKLAREMGeKAARHALENFDYKKLARHCLN 373
Cdd:PLN02871  386 --------DVDDCVEKLETLLADPELRERMG-AAAREEVEKWDWRAATRKLRN 429
stp2 TIGR03088
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ...
 234-301 1.28e-07

sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.


Pssm-ID: 132132 [Multi-domain]  Cd Length: 374  Bit Score: 53.19  E-value: 1.28e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1277773223 234 REMVPFLLNAANIYAAPSRIEGFGMIQVEAMACGTPVISIDAMGPKDTIVHGETGFLAKVGGTVELTD 301
Cdd:TIGR03088 263 RDDVPALMQALDLFVLPSLAEGISNTILEAMASGLPVIATAVGGNPELVQHGVTGALVPPGDAVALAR 330
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 118-346 2.13e-07

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 52.29  E-value: 2.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 118 DMVDVKNFEVLHVGYDPKLFRPLPKdqagVREVRRMFGVKDDEKMILTMGGDTTSKGAQEMIVALAKVNQQFKNWKYVCK 197
Cdd:cd03812   153 GEVENGKFKVIPNGIDIEKYKFNKE----KRRKRRKLLILEDKLVLGHVGRFNEQKNHSFLIDIFEELKKKNPNVKLVLV 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 198 STTSACahnhhEEELNLMDKLGLpKDKIVYVTddfSREMVPFLLNAANIYAAPSRIEGFGMIQVEAMACGTPVISIDAmG 277
Cdd:cd03812   229 GEGELK-----EKIKEKVKELGL-EDKVIFLG---FRNDVSEILSAMDVFLFPSLYEGLPLVAVEAQASGLPCLLSDT-I 298

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 278 PKDTIVHGETGFLakvggTVELT-DEWVNeemgfdEAFKVKFEKPKIFAYRADIDELADYTLKLLTDEKL 346
Cdd:cd03812   299 TKECDITNNVEFL-----PLNETpSTWAE------KILKLIKRKRRINKEINKEKKELGYDDESLELTLL 357
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 244-367 2.41e-07

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 51.92  E-value: 2.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 244 ANIYAAPSRIEGFGMIQVEAMACGTPVISIDA-MGPKDTIVHGETGFLAKVGgtveltdewvneemgfdeafkvkfekpk 322
Cdd:cd04949   235 AYLSLLTSQMEGFGLTLMEAIGHGLPVVSYDVkYGPSELIEDGENGYLIEKN---------------------------- 286

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1277773223 323 ifayraDIDELADYTLKLLTDEKLAREMGEKAARHAlENFDYKKL 367
Cdd:cd04949   287 ------NIDALADKIIELLNDPEKLQQFSEESYKIA-EKYSTENV 324
GT4_mannosyltransferase-like cd03822
mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most ...
 143-358 5.47e-07

mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.


Pssm-ID: 340849 [Multi-domain]  Cd Length: 370  Bit Score: 51.23  E-value: 5.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 143 DQAGVREVRRMFGVkDDEKMILTMGGDTTSKGAQEMIVALAKVNQQFKNWKYVCKSTTSA-CAHNHHEEELNLMDKLGLP 221
Cdd:cd03822   171 PQDPTTALKRLLLP-EGKKVILTFGFIGPGKGLEILLEALPELKAEFPDVRLVIAGELHPsLARYEGERYRKAAIEELGL 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 222 KDKIVYVTDDFSREMVPFLLNAANIYAAPSRIEGF---GMIQVeAMACGTPVISIDamgpkdtivhgetgflakVGGTVE 298
Cdd:cd03822   250 QDHVDFHNNFLPEEEVPRYISAADVVVLPYLNTEQsssGTLSY-AIACGKPVISTP------------------LRHAEE 310

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 299 LTDEwvneemgfDEAFKVKFEKPkifayradiDELADYTLKLLTDEKLAREMGEKAARHA 358
Cdd:cd03822   311 LLAD--------GRGVLVPFDDP---------SAIAEAILRLLEDDERRQAIAERAYAYA 353
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 49-375 2.48e-06

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 48.86  E-value: 2.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223  49 FYRAIKPDVV-----IGIGwwadtPQLIREPQKFNIlPVPWLLSDGWVANYHS--DINALPLVFVTSFWVKETYKRDMVD 121
Cdd:cd03823    91 LLEDFRPDVVhthnlSGLG-----ASLLDAARDLGI-PVVHTLHDYWLLCPRQflFKKGGDAVLAPSRFTANLHEANGLF 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 122 VKNFEVLHVGYDPKLfRPLPKDQAGVREVRrmFGVkddekmiltMGGDTTSKGAQEMIVALAKVnqQFKNWKYVckstts 201
Cdd:cd03823   165 SARISVIPNAVEPDL-APPPRRRPGTERLR--FGY---------IGRLTEEKGIDLLVEAFKRL--PREDIELV------ 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 202 ACAHNHHEEELNLMDKLGlpkdkiVYVTDDFSREMVPFLLNAANIYAAPSR-IEGFGMIQVEAMACGTPVISIDAMGPKD 280
Cdd:cd03823   225 IAGHGPLSDERQIEGGRR------IAFLGRVPTDDIKDFYEKIDVLVVPSIwPEPFGLVVREAIAAGLPVIASDLGGIAE 298

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 281 TIVHGETGFLAKVGgtveltdewvneemgfdeafkvkfekpkifayraDIDELADYTLKLLTDEKLAREMGEkaarHALE 360
Cdd:cd03823   299 LIQPGVNGLLFAPG----------------------------------DAEDLAAAMRRLLTDPALLERLRA----GAEP 340

                         330
                  ....*....|....*
gi 1277773223 361 NFDYKKLARHCLNIL 375
Cdd:cd03823   341 PRSTESQAEEYLKLY 355
MSMEG_0565_glyc TIGR04047
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ...
 106-272 3.94e-06

glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274943 [Multi-domain]  Cd Length: 373  Bit Score: 48.55  E-value: 3.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 106 VTSFW---VKETYKRDMVDVKNfevlhvGYDPKLFRPLPKDQAGVreVRRMFGVkDDEKMILTMGGDTTSKGAQEMIVAL 182
Cdd:TIGR04047 145 VSAAWaaeLRAEWGIDATVVPN------GVDAARFSPAADAADAA--LRRRLGL-RGGPYVLAVGGIEPRKNTIDLLEAF 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 183 AKVNQQFKNWKYVCKSTTSACAHNHHEEE-LNLMDKLGLPKDKIVyVTDDFSREMVPFLLNAANIYAAPSRIEGFGMIQV 261
Cdd:TIGR04047 216 ALLRARRPQAQLVIAGGATLFDYDAYRREfRARAAELGVDPGPVV-ITGPVPDADLPALYRCADAFAFPSLKEGFGLVVL 294

                         170
                  ....*....|.
gi 1277773223 262 EAMACGTPVIS 272
Cdd:TIGR04047 295 EALASGIPVVA 305
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 163-369 1.57e-05

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 46.29  E-value: 1.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 163 ILTMGGDTTSKGAQEMIVALAKVNQQFKNWKYvcKSTTSACAHNHHE---EELNLMDKLGL----PKDKIVYvtddfsre 235
Cdd:cd03799   177 ILTVGRLTEKKGLEYAIEAVAKLAQKYPNIEY--QIIGDGDLKEQLQqliQELNIGDCVKLlgwkPQEEIIE-------- 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 236 mvpfLLNAANIYAAPS------RIEGFGMIQVEAMACGTPVISIDAMGPKDTIVHGETGFLAKVGgtveltdewvneemg 309
Cdd:cd03799   247 ----ILDEADIFIAPSvtaadgDQDGPPNTLKEAMAMGLPVISTEHGGIPELVEDGVSGFLVPER--------------- 307

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1277773223 310 fdeafkvkfekpkifayraDIDELADYTLKLLTDEKLAREMGeKAARHALE-NFDYKKLAR 369
Cdd:cd03799   308 -------------------DAEAIAEKLTYLIEHPAIWPEMG-KAGRARVEeEYDINKLND 348
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
251-299 1.64e-05

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 46.24  E-value: 1.64e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1277773223 251 SRIEGFGMIQVEAMACGTPVISIDAM-GPKDTIVHGETGFLAKVGGTVEL 299
Cdd:PRK09922  265 SKFEGFPMTLLEAMSYGIPCISSDCMsGPRDIIKPGLNGELYTPGNIDEF 314
GT28_MurG cd03785
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4. ...
 51-361 4.58e-05

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340818 [Multi-domain]  Cd Length: 350  Bit Score: 44.90  E-value: 4.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223  51 RAIKPDVVIGIG-----------WWADTPQLIREPqkfNILP--VPWLLSdGWVANyhsdinalplVFVTSFWVKETYKR 117
Cdd:cd03785    86 RKFKPDVVIGFGgyvsgpvvlaaRLLGIPLIIHEQ---NAVPglANRLLS-RFADK----------VAVSFPETKKYFPA 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 118 DmvdvknfEVLHVGYdpklfrPLPKDQAGVREVRRMFGVKDDEKMILTMGGdttSKGA----QEMIVALAKVNQqfKNWK 193
Cdd:cd03785   152 A-------KVVVTGN------PVREEILNLRKELKRFGLPPDKPTLLVFGG---SQGArainRAVPKALPKLLE--RGIQ 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 194 YVCksttsACAHNHHEEELNLMDKLGLPkdkivYVTDDFSREMvPFLLNAANIyaAPSRiEGFGMIQvEAMACGTPVISI 273
Cdd:cd03785   214 VIH-----QTGKGDYDEVKKLYEDLGIN-----VKVFPFIDDM-AAAYAAADL--VISR-AGASTIA-ELTAAGKPAILI 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 274 damgPKDTIVHGETG----FLAKVGGTVELTDEwvneemgfdeafkvkfekpkifayRADIDELADYTLKLLTDEKLARE 349
Cdd:cd03785   279 ----PYPYAADDHQEanarALEKAGAAIVIDQE------------------------ELTPEVLAEAILDLLNDPERLKK 330

                         330
                  ....*....|..
gi 1277773223 350 MGEKAARHALEN 361
Cdd:cd03785   331 MAEAAKKLAKPD 342
PLN00142 PLN00142
sucrose synthase
 250-289 6.26e-05

sucrose synthase


Pssm-ID: 215073 [Multi-domain]  Cd Length: 815  Bit Score: 44.97  E-value: 6.26e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1277773223 250 PSRIEGFGMIQVEAMACGTPVISIDAMGPKDTIVHGETGF 289
Cdd:PLN00142  673 PALYEAFGLTVVEAMTCGLPTFATCQGGPAEIIVDGVSGF 712
PHA01633 PHA01633
putative glycosyl transferase group 1
 233-367 2.15e-04

putative glycosyl transferase group 1


Pssm-ID: 107050 [Multi-domain]  Cd Length: 335  Bit Score: 43.04  E-value: 2.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 233 SREMVPFLLNAANIYAAPSRIEGFGMIQVEAMACGTPVISiDAMGPKDTIVHGETGFLAKvGGTVEltdEWVNEEMGfde 312
Cdd:PHA01633  213 SREYIFAFYGAMDFTIVPSGTEGFGMPVLESMAMGTPVIH-QLMPPLDEFTSWQWNLLIK-SSKVE---EYYDKEHG--- 284

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1277773223 313 afkvkfEKPKIfaYRADIDELADYTL--KLLTD-EKLAREMGEKAARHALENFdYKKL 367
Cdd:PHA01633  285 ------QKWKI--HKFQIEDMANAIIlaFELQDrEERSMKLKELAKKYDIRNL-YTRF 333
PRK15490 PRK15490
Vi polysaccharide biosynthesis glycosyltransferase TviE;
216-299 1.03e-03

Vi polysaccharide biosynthesis glycosyltransferase TviE;


Pssm-ID: 185387 [Multi-domain]  Cd Length: 578  Bit Score: 41.22  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 216 DKLGLpKDKIVYVtdDFSREmVPFLLNAANIYAAPSRIEGFGMIQVEAMACGTPVISIDAMGPKDTIVHGETGFLAKVGG 295
Cdd:PRK15490  449 EQLGI-LERILFV--GASRD-VGYWLQKMNVFILFSRYEGLPNVLIEAQMVGVPVISTPAGGSAECFIEGVSGFILDDAQ 524


                  ....
gi 1277773223 296 TVEL 299
Cdd:PRK15490  525 TVNL 528
GT4_ALG11-like cd03806
alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related ...
 210-362 1.98e-03

alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown to block the early steps of core biosynthesis that takes place on the cytoplasmic face of the ER and lead to a defect in the assembly of lipid-linked oligosaccharides.


Pssm-ID: 340835 [Multi-domain]  Cd Length: 419  Bit Score: 39.90  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 210 EELNLMDKLGLPKDKIVYVTDDFSREMVPFLLNAA-------NiyaapsriEGFGMIQVEAMACGTPVISIDAMGPKDTI 282
Cdd:cd03806   292 EALKLLAKELILEDSVEFVVDAPYEELKELLSTASiglhtmwN--------EHFGIGVVEYMAAGLIPLAHASAGPLLDI 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 283 V----HGETGFLAKvggtveltdewvneemgfdeafkvkfekpkifayraDIDELADYTLKLLTDEKLAREMGEKAARHA 358
Cdd:cd03806   364 VvpwdGGPTGFLAS------------------------------------TPEEYAEAIEKILTLSEEERLQRREAARSS 407


                  ....
gi 1277773223 359 LENF 362
Cdd:cd03806   408 AERF 411
PLN02949 PLN02949
transferase, transferring glycosyl groups
 180-291 4.82e-03

transferase, transferring glycosyl groups


Pssm-ID: 215511 [Multi-domain]  Cd Length: 463  Bit Score: 38.95  E-value: 4.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277773223 180 VALAKVNQQFKNWKYVcksTTSACAHNHHEEEL-NLMDK---LGLpKDKIVYVTDDFSREMVPFLLNA-ANIYAAPSriE 254
Cdd:PLN02949  292 LALEKLDADVPRPKLQ---FVGSCRNKEDEERLqKLKDRakeLGL-DGDVEFHKNVSYRDLVRLLGGAvAGLHSMID--E 365

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1277773223 255 GFGMIQVEAMACGTPVISIDAMGPKDTIV---HGE-TGFLA 291
Cdd:PLN02949  366 HFGISVVEYMAAGAVPIAHNSAGPKMDIVldeDGQqTGFLA 406
GT5_Glycogen_synthase_DULL1-like cd03791
Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 ...
 231-290 9.37e-03

Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 family of glycosyltransferases. Glycogen synthase (EC:2.4.1.21) catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family includes starch synthases of plants, such as DULL1 in Zea mays and glycogen synthases of various organisms.


Pssm-ID: 340822 [Multi-domain]  Cd Length: 474  Bit Score: 37.93  E-value: 9.37e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1277773223 231 DFSREMVPFLLNAANIYAAPSRIEGFGMIQVEAMACGTPVIsidAM---GPKDTIVHGE------TGFL 290
Cdd:cd03791   356 GFDEALAHRIYAGADFFLMPSRFEPCGLVQMYAMRYGTLPI---VRrtgGLADTVFDYDpetgegTGFV 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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