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Conserved domains on  [gi|1277932423|gb|PIV32009|]
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tyrosine--tRNA ligase [Candidatus Wolfebacteria bacterium CG02_land_8_20_14_3_00_37_12]

Protein Classification

tyrosine--tRNA ligase( domain architecture ID 10013090)

tyrosine--tRNA ligase catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK08560 PRK08560
tyrosyl-tRNA synthetase; Validated
 3-366 2.10e-151

tyrosyl-tRNA synthetase; Validated


:

Pssm-ID: 236286 [Multi-domain]  Cd Length: 329  Bit Score: 430.06  E-value: 2.10e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423   3 IQEKINLISRQTEEIITLNDLEFLLKSGEPLKHYIGFEISGKIHLGsGLICMQKIKDFADAGVKVHIFLADYHAWINDKl 82
Cdd:PRK08560    1 IEERLELITRNTEEVVTEEELRELLESKEEPKAYIGFEPSGKIHLG-HLLTMNKLADLQKAGFKVTVLLADWHAYLNDK- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423  83 gGDLEAIKKIAvnyfkEGLVAAYKCLGGNPKDLNFILASEFYRKNDnYWPTVLDVAKNTTLARMKRSITILGKKEgEEVD 162
Cdd:PRK08560   79 -GDLEEIRKVA-----EYNKKVFEALGLDPDKTEFVLGSEFQLDKE-YWLLVLKLAKNTTLARARRSMTIMGRRM-EEPD 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 163 FAKLMYPAMQVADIFAGGFHFSHAGIDQRKANVIARDVAKQLKFSqlkinnkpiKPVAAHTHLLAGLNKPAVwpvpegfn 242
Cdd:PRK08560  151 VSKLVYPLMQVADIFYLDVDIAVGGMDQRKIHMLAREVLPKLGYK---------KPVCIHTPLLTGLDGGGI-------- 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 243 kgelqtsmKMSKSKPDSAVFIHDSEEEIRRKIKKAFCQEGEIEFNPIIDWVEYLIFSREEKITIERQPEHGGNLKISGID 322
Cdd:PRK08560  214 --------KMSKSKPGSAIFVHDSPEEIRRKIKKAYCPPGEVEGNPVLEIAKYHIFPRYDPFVIERPEKYGGDLEYESYE 285

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1277932423 323 ELKKIFKNKELHPEDLKKFTADYLIELLKPAREYFEKGEGKKML 366
Cdd:PRK08560  286 ELERDYAEGKLHPMDLKNAVAEYLIEILEPVREYLEEGPELLEL 329
 
Name Accession Description Interval E-value
PRK08560 PRK08560
tyrosyl-tRNA synthetase; Validated
 3-366 2.10e-151

tyrosyl-tRNA synthetase; Validated


Pssm-ID: 236286 [Multi-domain]  Cd Length: 329  Bit Score: 430.06  E-value: 2.10e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423   3 IQEKINLISRQTEEIITLNDLEFLLKSGEPLKHYIGFEISGKIHLGsGLICMQKIKDFADAGVKVHIFLADYHAWINDKl 82
Cdd:PRK08560    1 IEERLELITRNTEEVVTEEELRELLESKEEPKAYIGFEPSGKIHLG-HLLTMNKLADLQKAGFKVTVLLADWHAYLNDK- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423  83 gGDLEAIKKIAvnyfkEGLVAAYKCLGGNPKDLNFILASEFYRKNDnYWPTVLDVAKNTTLARMKRSITILGKKEgEEVD 162
Cdd:PRK08560   79 -GDLEEIRKVA-----EYNKKVFEALGLDPDKTEFVLGSEFQLDKE-YWLLVLKLAKNTTLARARRSMTIMGRRM-EEPD 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 163 FAKLMYPAMQVADIFAGGFHFSHAGIDQRKANVIARDVAKQLKFSqlkinnkpiKPVAAHTHLLAGLNKPAVwpvpegfn 242
Cdd:PRK08560  151 VSKLVYPLMQVADIFYLDVDIAVGGMDQRKIHMLAREVLPKLGYK---------KPVCIHTPLLTGLDGGGI-------- 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 243 kgelqtsmKMSKSKPDSAVFIHDSEEEIRRKIKKAFCQEGEIEFNPIIDWVEYLIFSREEKITIERQPEHGGNLKISGID 322
Cdd:PRK08560  214 --------KMSKSKPGSAIFVHDSPEEIRRKIKKAYCPPGEVEGNPVLEIAKYHIFPRYDPFVIERPEKYGGDLEYESYE 285

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1277932423 323 ELKKIFKNKELHPEDLKKFTADYLIELLKPAREYFEKGEGKKML 366
Cdd:PRK08560  286 ELERDYAEGKLHPMDLKNAVAEYLIEILEPVREYLEEGPELLEL 329
TyrRS_core cd00805
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) ...
 33-349 4.50e-53

catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) catalytic core domain. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formationof the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173902 [Multi-domain]  Cd Length: 269  Bit Score: 176.64  E-value: 4.50e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423  33 LKHYIGFEISG-KIHLGSgLICMQKIKDFADAGVKVHIFLADYHAWINDKLG-------GDLEAIKKIAvNYFKEGLVAA 104
Cdd:cd00805     1 LKVYIGFDPTApSLHLGH-LVPLMKLRDFQQAGHEVIVLIGDATAMIGDPSGkseerklLDLELIRENA-KYYKKQLKAI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 105 YKCLGgnPKDLNFILASEFYrkNDNYWPTVLDVAKNTTLARMKRSITILGK-KEGEEVDFAKLMYPAMQVADIFAGGFHF 183
Cdd:cd00805    79 LDFIP--PEKAKFVNNSDWL--LSLYTLDFLRLGKHFTVNRMLRRDAVKVRlEEEEGISFSEFIYPLLQAYDFVYLDVDL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 184 SHAGIDQRKANVIARDVAKQLKFSqlkinnkpiKPVAAHTHLLAGLNKPavwpvpegfnkgelqtsmKMSKSKPDSA-VF 262
Cdd:cd00805   155 QLGGSDQRGNITLGRDLIRKLGYK---------KVVGLTTPLLTGLDGG------------------KMSKSEGNAIwDP 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 263 IHDSEEEIRRKIKKAFCQegeiefnPIIDWVEYLIFSREEKitierqpehggnlkisgIDELKKIFKNKELhPEDLKKFT 342
Cdd:cd00805   208 VLDSPYDVYQKIRNAFDP-------DVLEFLKLFTFLDYEE-----------------IEELEEEHAEGPL-PRDAKKAL 262


                  ....*..
gi 1277932423 343 ADYLIEL 349
Cdd:cd00805   263 AEELTKL 269
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
28-351 9.17e-38

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 137.41  E-value: 9.17e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423  28 KSGEPLKHYIGFEISGKIHLGsGLICMQKIKDFADAGVKVHIFLADYHAWINDKLGGDLEAIKKiAVNYFkEGLVAAYKC 107
Cdd:pfam00579   1 KKNRPLRVYSGIDPTGPLHLG-YLVPLMKLRQFQQAGHEVFFLIGDLHAIIGDPSKSPERKLLS-RETVL-ENAIKAQLA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 108 LGGNPKDLNFILASEfYRKNDNYWPTVLDVAKNTTLARMKRSITILGK-KEGEEVDFAKLMYPAMQVADIFAGGFHFSHA 186
Cdd:pfam00579  78 CGLDPEKAEIVNNSD-WLEHLELAWLLRDLGKHFSLNRMLQFKDVKKRlEQGPGISLGEFTYPLLQAYDILLLKADLQPG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 187 GIDQRKANVIARDVAKQLKFSQLKinnkpiKPVAAHTHLLAGLNkpavwpvpegfnkGElqtsMKMSKSKPDSAVFIHDS 266
Cdd:pfam00579 157 GSDQWGNIELGRDLARRFNKKIFK------KPVGLTNPLLTGLD-------------GG----KKMSKSAGNSAIFLDDD 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 267 EEEIRRKIKKAFCQEGEIEfnpiidWVEYLIFSREEKITIERQPEHGGNLKISGIDELKKIFKNKELHPEDLKKFTADYL 346
Cdd:pfam00579 214 PESVYKKIQKAYTDPDREV------RKDLKLFTFLSNEEIEILEAELGKSPYREAEELLAREVTGLVHGGDLKKAAAEAV 287


                  ....*
gi 1277932423 347 IELLK 351
Cdd:pfam00579 288 NKLLQ 292
tyrS TIGR00234
tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up ...
 5-358 9.17e-32

tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up tryptophanyl-tRNA synthetases at scores of 0 and below. The proteins found by this model have a deep split between two groups. One group contains bacterial and organellar eukaryotic examples. The other contains archaeal and cytosolic eukaryotic examples. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272976 [Multi-domain]  Cd Length: 378  Bit Score: 123.28  E-value: 9.17e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423   5 EKINLISRQTEEIITLNDLEFLLKS-GEPLKHYIGFEISG-KIHLGSgLICMQKIKDFADAGVKVHIFLADYHAWINDKL 82
Cdd:TIGR00234   3 NILLLLTKRGLEVQTPEEEKDLLKLlERPLKLYLGFDPTApSLHLGH-LVPLLKLRDFQQAGHEVIVLLGDFTALIGDPT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423  83 GgdLEAIKKIAVNYFKEGLVAAYKC---LGGNPKDLNFILASEfYRKNDNYWPTVLDVAKNTTLARMKRSITILgKKEGE 159
Cdd:TIGR00234  82 G--KSEVRKILTREEVQENAENIKKqiaRFLDFEKAKFVYNSE-WLLKLNYTDFIRLLGKIFTVNRMLRRDAFS-SRFEE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 160 EVDFAKLMYPAMQVADIFAGGFHFSHAGIDQrKANVIA-RDVAKQlkfsqlkinNKPIKPVAAHTHLLAGLNKpavwpvp 238
Cdd:TIGR00234 158 NISLHEFIYPLLQAYDFVYLNVDLQLGGSDQ-WFNIRKgRDLARE---------NLPSLQFGLTVPLLTPADG------- 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 239 EGFNKgELQTSMKMSKSKPDSAVFIHDSEEEIRRKIKKAFC--QEGEIEF--------------NPIIDWVEYLI----- 297
Cdd:TIGR00234 221 EKMGK-SLGGAVSLDEGKYDFYQKVINTPDELVKKYLKLFTflGLEEIEQlvelkgpnprevkeNLALEITKYVHgpeaa 299

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1277932423 298 ----------FSR---EEKITIERQPEHGGNLKISGIDELKKIFKNKELHPEDLKK---FTADYLIELLKPAREYFE 358
Cdd:TIGR00234 300 laaeeiseaiFSGglnPDEVPIFRPEKFGGPITLADLLVLSGLFPSKSEARRDIKNggvYINGEKVEDLEPIRKELE 376
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 141-355 4.87e-11

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 63.14  E-value: 4.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 141 TTLARMKRSITI---LGKKEGEEVDFAKLMYPAMQVADIFAggFHFSH--AGIDQrKANV-IARDVAKqlKFsqlkiNNk 214
Cdd:COG0180    99 TPLGELERMPQFkdkSAKNGKENVNAGLLTYPVLMAADILL--YKADLvpVGEDQ-KQHLeLTRDIAR--RF-----NH- 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 215 pikpvaahthlLAGlnkpAVWPVPEGFNKGELQTSM------KMSKSKpDSAVFIHDSEEEIRRKIKKAFcqegeiefnp 288
Cdd:COG0180   168 -----------RYG----EVFPEPEALIPEEGARIPgldgrkKMSKSY-GNTINLLDDPKEIRKKIKSAV---------- 221

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1277932423 289 iIDwveylifSREEKITIERQPEhGGNL--------KISGIDELKKIFKNKELHPEDLKKFTADYLIELLKPARE 355
Cdd:COG0180   222 -TD-------SERLRYDDPGKPE-VCNLftiysafsGKEEVEELEAEYRAGGIGYGDLKKALAEAVVEFLAPIRE 287
 
Name Accession Description Interval E-value
PRK08560 PRK08560
tyrosyl-tRNA synthetase; Validated
 3-366 2.10e-151

tyrosyl-tRNA synthetase; Validated


Pssm-ID: 236286 [Multi-domain]  Cd Length: 329  Bit Score: 430.06  E-value: 2.10e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423   3 IQEKINLISRQTEEIITLNDLEFLLKSGEPLKHYIGFEISGKIHLGsGLICMQKIKDFADAGVKVHIFLADYHAWINDKl 82
Cdd:PRK08560    1 IEERLELITRNTEEVVTEEELRELLESKEEPKAYIGFEPSGKIHLG-HLLTMNKLADLQKAGFKVTVLLADWHAYLNDK- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423  83 gGDLEAIKKIAvnyfkEGLVAAYKCLGGNPKDLNFILASEFYRKNDnYWPTVLDVAKNTTLARMKRSITILGKKEgEEVD 162
Cdd:PRK08560   79 -GDLEEIRKVA-----EYNKKVFEALGLDPDKTEFVLGSEFQLDKE-YWLLVLKLAKNTTLARARRSMTIMGRRM-EEPD 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 163 FAKLMYPAMQVADIFAGGFHFSHAGIDQRKANVIARDVAKQLKFSqlkinnkpiKPVAAHTHLLAGLNKPAVwpvpegfn 242
Cdd:PRK08560  151 VSKLVYPLMQVADIFYLDVDIAVGGMDQRKIHMLAREVLPKLGYK---------KPVCIHTPLLTGLDGGGI-------- 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 243 kgelqtsmKMSKSKPDSAVFIHDSEEEIRRKIKKAFCQEGEIEFNPIIDWVEYLIFSREEKITIERQPEHGGNLKISGID 322
Cdd:PRK08560  214 --------KMSKSKPGSAIFVHDSPEEIRRKIKKAYCPPGEVEGNPVLEIAKYHIFPRYDPFVIERPEKYGGDLEYESYE 285

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1277932423 323 ELKKIFKNKELHPEDLKKFTADYLIELLKPAREYFEKGEGKKML 366
Cdd:PRK08560  286 ELERDYAEGKLHPMDLKNAVAEYLIEILEPVREYLEEGPELLEL 329
PTZ00126 PTZ00126
tyrosyl-tRNA synthetase; Provisional
 3-366 7.43e-93

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 240282 [Multi-domain]  Cd Length: 383  Bit Score: 283.12  E-value: 7.43e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423   3 IQEKINLISRQTEEIITLNDLEFLLKSGEPLKHYIGFEISGKIHLGSGLICMQKIKDFADAGVKVHIFLADYHAWINDKL 82
Cdd:PTZ00126   37 LEERVKLCLSIGEECIQPEELRELLKLKERPICYDGFEPSGRMHIAQGILKAINVNKLTKAGCVFVFWVADWFALLNNKM 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423  83 GGDLEAIKKIAvNYFKEglvaAYKCLGGNPKDLNFILASEFYRKNDN-YWPTVLDVAKNTTLARMKRSITILGKKEGEEV 161
Cdd:PTZ00126  117 GGDLEKIRKVG-EYFIE----VWKAAGMDMDNVRFLWASEEINKNPNdYWLRVMDIARSFNITRIKRCSQIMGRSEGDEQ 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 162 DFAKLMYPAMQVADIFAGGFHFSHAGIDQRKANVIARDvakqlkFSQL-KINNKPIkpVAAHtHLLAGLnkpavwpvpeg 240
Cdd:PTZ00126  192 PCAQILYPCMQCADIFYLKADICQLGMDQRKVNMLARE------YCDKkKIKKKPI--ILSH-HMLPGL----------- 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 241 fnkgeLQTSMKMSKSKPDSAVFIHDSEEEIRRKIKKAFCQEGEIEFNPIIDWVEYLIFSREEKITIERQPEHGGNLKISG 320
Cdd:PTZ00126  252 -----LEGQEKMSKSDPNSAIFMEDSEEDVNRKIKKAYCPPGVIEGNPILAYFKSIVFPAFNSFTVLRKEKNGGDVTYTT 326

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1277932423 321 IDELKKIFKNKELHPEDLKKFTADYLIELLKPAREYFEKGEGKKML 366
Cdd:PTZ00126  327 YEELEKDYLSGALHPGDLKPALAKYLNLMLQPVRDHFQNNPEAKSL 372
PTZ00348 PTZ00348
tyrosyl-tRNA synthetase; Provisional
 1-357 7.61e-54

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 173541 [Multi-domain]  Cd Length: 682  Bit Score: 188.57  E-value: 7.61e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423   1 MDIQEKINLISRQTEEIITLNDLEFLLKSGEPLKHYIGFEISGKIHLGSGLICMQKIKDFADAGVKVHIFLADYHAWIND 80
Cdd:PTZ00348    1 MNTDERYKLLRSVGEECIQESELRNLIEKKPLIRCYDGFEPSGRMHIAQGIFKAVNVNKCTQAGCEFVFWVADWFALMND 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423  81 KLGGDLEAIKKIAvnyfkEGLVAAYKCLGGNPKDLNFILAS-EFYRKNDNYWPTVLDVAKNTTLARMKRSITILGKKEGe 159
Cdd:PTZ00348   81 KVGGELEKIRIVG-----RYLIEVWKAAGMDMDKVLFLWSSeEITNHANTYWRTVLDIGRQNTIARIKKCCTIMGKTEG- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 160 EVDFAKLMYPAMQVADIFAGGFHFSHAGIDQRKANVIARDVAKQLkfsqlkinNKPIKPVAAHTHLLAGLNkpavwpvpe 239
Cdd:PTZ00348  155 TLTAAQVLYPLMQCADIFFLKADICQLGLDQRKVNMLAREYCDLI--------GRKLKPVILSHHMLAGLK--------- 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 240 gfnkgelQTSMKMSKSKPDSAVFIHDSEEEIRRKIKKAFC-----QEGEI----------EFNPIIDWVEYLIFSREEKI 304
Cdd:PTZ00348  218 -------QGQAKMSKSDPDSAIFMEDTEEDVARKIRQAYCprvkqSASEItddgapvatdDRNPVLDYFQCVVYARPGAV 290

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1277932423 305 TIERQPEHggnlkiSGIDELKKIFKNKELHPEDLKKFTADYLIELLKPAREYF 357
Cdd:PTZ00348  291 ATIDGTTY------ATYEDLEQAFVSDEVSEEALKSCLIDEVNALLEPVRQHF 337
TyrRS_core cd00805
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) ...
 33-349 4.50e-53

catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) catalytic core domain. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formationof the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173902 [Multi-domain]  Cd Length: 269  Bit Score: 176.64  E-value: 4.50e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423  33 LKHYIGFEISG-KIHLGSgLICMQKIKDFADAGVKVHIFLADYHAWINDKLG-------GDLEAIKKIAvNYFKEGLVAA 104
Cdd:cd00805     1 LKVYIGFDPTApSLHLGH-LVPLMKLRDFQQAGHEVIVLIGDATAMIGDPSGkseerklLDLELIRENA-KYYKKQLKAI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 105 YKCLGgnPKDLNFILASEFYrkNDNYWPTVLDVAKNTTLARMKRSITILGK-KEGEEVDFAKLMYPAMQVADIFAGGFHF 183
Cdd:cd00805    79 LDFIP--PEKAKFVNNSDWL--LSLYTLDFLRLGKHFTVNRMLRRDAVKVRlEEEEGISFSEFIYPLLQAYDFVYLDVDL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 184 SHAGIDQRKANVIARDVAKQLKFSqlkinnkpiKPVAAHTHLLAGLNKPavwpvpegfnkgelqtsmKMSKSKPDSA-VF 262
Cdd:cd00805   155 QLGGSDQRGNITLGRDLIRKLGYK---------KVVGLTTPLLTGLDGG------------------KMSKSEGNAIwDP 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 263 IHDSEEEIRRKIKKAFCQegeiefnPIIDWVEYLIFSREEKitierqpehggnlkisgIDELKKIFKNKELhPEDLKKFT 342
Cdd:cd00805   208 VLDSPYDVYQKIRNAFDP-------DVLEFLKLFTFLDYEE-----------------IEELEEEHAEGPL-PRDAKKAL 262


                  ....*..
gi 1277932423 343 ADYLIEL 349
Cdd:cd00805   263 AEELTKL 269
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
28-351 9.17e-38

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 137.41  E-value: 9.17e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423  28 KSGEPLKHYIGFEISGKIHLGsGLICMQKIKDFADAGVKVHIFLADYHAWINDKLGGDLEAIKKiAVNYFkEGLVAAYKC 107
Cdd:pfam00579   1 KKNRPLRVYSGIDPTGPLHLG-YLVPLMKLRQFQQAGHEVFFLIGDLHAIIGDPSKSPERKLLS-RETVL-ENAIKAQLA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 108 LGGNPKDLNFILASEfYRKNDNYWPTVLDVAKNTTLARMKRSITILGK-KEGEEVDFAKLMYPAMQVADIFAGGFHFSHA 186
Cdd:pfam00579  78 CGLDPEKAEIVNNSD-WLEHLELAWLLRDLGKHFSLNRMLQFKDVKKRlEQGPGISLGEFTYPLLQAYDILLLKADLQPG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 187 GIDQRKANVIARDVAKQLKFSQLKinnkpiKPVAAHTHLLAGLNkpavwpvpegfnkGElqtsMKMSKSKPDSAVFIHDS 266
Cdd:pfam00579 157 GSDQWGNIELGRDLARRFNKKIFK------KPVGLTNPLLTGLD-------------GG----KKMSKSAGNSAIFLDDD 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 267 EEEIRRKIKKAFCQEGEIEfnpiidWVEYLIFSREEKITIERQPEHGGNLKISGIDELKKIFKNKELHPEDLKKFTADYL 346
Cdd:pfam00579 214 PESVYKKIQKAYTDPDREV------RKDLKLFTFLSNEEIEILEAELGKSPYREAEELLAREVTGLVHGGDLKKAAAEAV 287


                  ....*
gi 1277932423 347 IELLK 351
Cdd:pfam00579 288 NKLLQ 292
tyrS TIGR00234
tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up ...
 5-358 9.17e-32

tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up tryptophanyl-tRNA synthetases at scores of 0 and below. The proteins found by this model have a deep split between two groups. One group contains bacterial and organellar eukaryotic examples. The other contains archaeal and cytosolic eukaryotic examples. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272976 [Multi-domain]  Cd Length: 378  Bit Score: 123.28  E-value: 9.17e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423   5 EKINLISRQTEEIITLNDLEFLLKS-GEPLKHYIGFEISG-KIHLGSgLICMQKIKDFADAGVKVHIFLADYHAWINDKL 82
Cdd:TIGR00234   3 NILLLLTKRGLEVQTPEEEKDLLKLlERPLKLYLGFDPTApSLHLGH-LVPLLKLRDFQQAGHEVIVLLGDFTALIGDPT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423  83 GgdLEAIKKIAVNYFKEGLVAAYKC---LGGNPKDLNFILASEfYRKNDNYWPTVLDVAKNTTLARMKRSITILgKKEGE 159
Cdd:TIGR00234  82 G--KSEVRKILTREEVQENAENIKKqiaRFLDFEKAKFVYNSE-WLLKLNYTDFIRLLGKIFTVNRMLRRDAFS-SRFEE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 160 EVDFAKLMYPAMQVADIFAGGFHFSHAGIDQrKANVIA-RDVAKQlkfsqlkinNKPIKPVAAHTHLLAGLNKpavwpvp 238
Cdd:TIGR00234 158 NISLHEFIYPLLQAYDFVYLNVDLQLGGSDQ-WFNIRKgRDLARE---------NLPSLQFGLTVPLLTPADG------- 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 239 EGFNKgELQTSMKMSKSKPDSAVFIHDSEEEIRRKIKKAFC--QEGEIEF--------------NPIIDWVEYLI----- 297
Cdd:TIGR00234 221 EKMGK-SLGGAVSLDEGKYDFYQKVINTPDELVKKYLKLFTflGLEEIEQlvelkgpnprevkeNLALEITKYVHgpeaa 299

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1277932423 298 ----------FSR---EEKITIERQPEHGGNLKISGIDELKKIFKNKELHPEDLKK---FTADYLIELLKPAREYFE 358
Cdd:TIGR00234 300 laaeeiseaiFSGglnPDEVPIFRPEKFGGPITLADLLVLSGLFPSKSEARRDIKNggvYINGEKVEDLEPIRKELE 376
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 36-359 8.37e-31

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 119.74  E-value: 8.37e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423  36 YIGFEISGKIHLGSGLICMQKIKDFADaGVKVHIFLADYHAWINDKlggDLEAIKKIAVnyfkEGLVAAYKCLGGNPKDL 115
Cdd:TIGR00233   6 LTGIQPSGKMHLGHYLGAIQTKWLQQF-GVELFICIADLHAITVKQ---TDPDALRKAR----EELAADYLAVGLDPEKT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 116 NFILASEFYRKNDNYWPtvldVAKNTTLARMKRSITILGKKEGEEVDFAKLMYPAMQVADIFAGGFHFSHAGIDQRKANV 195
Cdd:TIGR00233  78 FIFLQSDYPEHYELAWL----LSCQVTFGELKRMTQFKDKSQAENVPIGLLSYPVLQAADILLYQADLVPVGIDQDQHLE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 196 IARDVAKQLKFsqlKINNKPIKPVAAHTHLLAGLNKPavwpvpegfnkgelqTSMKMSKSKPDSAVFIHDSEEEIRRKIK 275
Cdd:TIGR00233 154 LTRDLAERFNK---KFKNFFPKPESLISKFFPRLMGL---------------SGKKMSKSDPNSAIFLTDTPKQIKKKIR 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 276 KAFCQEGEiefnpiidwveylifsreekITIERQPEHGGN-----------LKISGIDELKKIF---KNKELHPEDLKKF 341
Cdd:TIGR00233 216 KAATDGGR--------------------VTLFEHREKPGVpnllviyqylsFFLIDDDKLKEIYeayKSGKLGYGECKKA 275

                         330
                  ....*....|....*...
gi 1277932423 342 TADYLIELLKPAREYFEK 359
Cdd:TIGR00233 276 LIEVLQEFLKEIQERRAE 293
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 42-278 3.50e-30

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 116.91  E-value: 3.50e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423  42 SGKIHLGSGLICMQKIKDFADAGVKVHIFLADYHAWINDKLggDLEAIKKIAVNYfkeglVAAYKCLGGNPKDLNFILAS 121
Cdd:cd00806     9 SGSLHLGHYLGAFRFWVWLQEAGYELFFFIADLHALTVKQL--DPEELRQNTREN-----AKDYLACGLDPEKSTIFFQS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 122 EFYRKNDNYWPtvldVAKNTTLARMKRSITILGKK-EGEEVDFAKLMYPAMQVADIFAGGFHFSHAGIDQrKANV-IARD 199
Cdd:cd00806    82 DVPEHYELAWL----LSCVVTFGELERMTGFKDKSaQGESVNIGLLTYPVLQAADILLYKACLVPVGIDQ-DPHLeLTRD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 200 VAKqlKFSQLkINNKPIKPVAAHTH--LLAGLNKPAVwpvpegfnkgelqtsmKMSKSKPDSAVFIHDSEEEIRRKIKKA 277
Cdd:cd00806   157 IAR--RFNKL-YGEIFPKPAALLSKgaFLPGLQGPSK----------------KMSKSDPNNAIFLTDSPKEIKKKIMKA 217


                  .
gi 1277932423 278 F 278
Cdd:cd00806   218 A 218
PRK12285 PRK12285
tryptophanyl-tRNA synthetase; Reviewed
 27-363 8.74e-25

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 237037 [Multi-domain]  Cd Length: 368  Bit Score: 103.79  E-value: 8.74e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423  27 LKSGEPLKHYIGFEISGKIHLGsGLICMQKIKDFADAGVKVHIFLADYHAWINDKLggDLEAIKKIAVNYfkeglVAAYK 106
Cdd:PRK12285   61 YRNGKPFAVYTGFMPSGPMHIG-HKMVFDELKWHQEFGANVYIPIADDEAYAARGL--SWEETREWAYEY-----ILDLI 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 107 CLGGNPKDLNFILASEfyrkNDNYWPTVLDVAKNTTLARMKrsiTILGKkeGEEVDFAKLMYPAMQVADIF----AGGFH 182
Cdd:PRK12285  133 ALGFDPDKTEIYFQSE----NIKVYDLAFELAKKVNFSELK---AIYGF--TGETNIGHIFYPATQAADILhpqlEEGPK 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 183 FS--HAGIDQ----RkanvIARDVAKqlkfsqlKINNKP--IKPVAAHTHLLAGLnkpavwpvpegfnkgelqTSMKMSK 254
Cdd:PRK12285  204 PTlvPVGIDQdphiR----LTRDIAE-------RLHGGYgfIKPSSTYHKFMPGL------------------TGGKMSS 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 255 SKPDSAVFIHDSEEEIRRKIKKAFcqEGeiefnpiidwveylifSREekiTIERQPEHGGNLKISGI------------D 322
Cdd:PRK12285  255 SKPESAIYLTDDPETVKKKIMKAL--TG----------------GRA---TLEEQRKLGGEPDECVVyelllyhleeddK 313

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1277932423 323 ELKKIF---KNKELHPEDLKKFTADYLIELLKPAREYFEKGEGK 363
Cdd:PRK12285  314 ELKEIYeecRSGELLCGECKKEAAEKIAEFLKEHQEKREEAREI 357
PTZ00348 PTZ00348
tyrosyl-tRNA synthetase; Provisional
 55-369 3.60e-15

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 173541 [Multi-domain]  Cd Length: 682  Bit Score: 76.86  E-value: 3.60e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423  55 QKIKDFADAGV--KVHIFLADYHAWINDKLGGDLEAIKkiAVNYFKEGLVAAYkclgGNPKDLNFILASEFYRKN-DNYW 131
Cdd:PTZ00348  396 DATKDFIAAHSdgTVTLVLPDWSAVASDEITGEEKDIS--AALEVNCALLKAY----GLPSEVKIVRENEVILGNpNDFW 469

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 132 PTVLDVAKNTTLARMKRSITILGKKEGEEVdfAKLMYpamqVADI-FAGGFHFSHAGIDqRKANVIARDVAKQlkfsqlk 210
Cdd:PTZ00348  470 VSVIGIARKNLLSHVEELYGGELRNAGQVI--AALMR----VATAlMLSASHVISTSLD-GGINEFAREYTKG------- 535

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 211 innkPIKPVAAHTHLLAGLNKPAVWPVPEGfnkgelqtsmkmskskPDSAVFIHDSEEEIRRKIKKAFCQEGEiEFNPII 290
Cdd:PTZ00348  536 ----RIECIQALEGRVPALHRPGAAPAVLG----------------ADDVLYLDDNDMDIRRKIKKAYSAPNE-EANPVI 594

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1277932423 291 DWVEYLIfSREEKITIERQPEHGGNLKISGIDELKKIFKNKELHPEDLKKFTADYLIELLKPAREYFEkGEGKKMLGEL 369
Cdd:PTZ00348  595 SVAQHLL-AQQGALSIERGEANGGNVAYNTPEALVADCGSGALHPADLKAAVSQLLLDRSAAARALLS-GELKKNMQTL 671
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 141-355 4.87e-11

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 63.14  E-value: 4.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 141 TTLARMKRSITI---LGKKEGEEVDFAKLMYPAMQVADIFAggFHFSH--AGIDQrKANV-IARDVAKqlKFsqlkiNNk 214
Cdd:COG0180    99 TPLGELERMPQFkdkSAKNGKENVNAGLLTYPVLMAADILL--YKADLvpVGEDQ-KQHLeLTRDIAR--RF-----NH- 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 215 pikpvaahthlLAGlnkpAVWPVPEGFNKGELQTSM------KMSKSKpDSAVFIHDSEEEIRRKIKKAFcqegeiefnp 288
Cdd:COG0180   168 -----------RYG----EVFPEPEALIPEEGARIPgldgrkKMSKSY-GNTINLLDDPKEIRKKIKSAV---------- 221

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1277932423 289 iIDwveylifSREEKITIERQPEhGGNL--------KISGIDELKKIFKNKELHPEDLKKFTADYLIELLKPARE 355
Cdd:COG0180   222 -TD-------SERLRYDDPGKPE-VCNLftiysafsGKEEVEELEAEYRAGGIGYGDLKKALAEAVVEFLAPIRE 287
PLN02486 PLN02486
aminoacyl-tRNA ligase
 111-355 4.39e-10

aminoacyl-tRNA ligase


Pssm-ID: 178104  Cd Length: 383  Bit Score: 60.53  E-value: 4.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 111 NPKDL---NFILASEFYRKNDNY-----WPTVLDVAKNTTLARMKRSITILGkkegeEVDFAKLMYPAMQVADIFAGGF- 181
Cdd:PLN02486  136 NAKDIiacGFDVERTFIFSDFDYvggafYKNMVKIAKCVTLNQVRGIFGFSG-----EDNIGKISFPAVQAAPSFPSSFp 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 182 HFSHAG----------IDQRKANVIARDVAKQLKFSqlkinnkpiKPVAAHTHLLaglnkPAVwpvpegfnKGElqtSMK 251
Cdd:PLN02486  211 HLFGGKdklrclipcaIDQDPYFRMTRDVAPRLGYY---------KPALIESRFF-----PAL--------QGE---SGK 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 252 MSKSKPDSAVFIHDSEEEIRRKIKK-AFCQEGEiefnpiidwveylifsreekiTIERQPEHGGNLKIS----------- 319
Cdd:PLN02486  266 MSASDPNSAIYVTDTPKEIKNKINKyAFSGGQD---------------------TVEEHRELGANLEVDipwkylnffle 324

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1277932423 320 GIDELKKI---FKNKELHPEDLKKFTADYLIELLKPARE 355
Cdd:PLN02486  325 DDAELERIkkeYGSGRMLTGEVKKRLIEVLTEIVERHQR 363
PRK00927 PRK00927
tryptophanyl-tRNA synthetase; Reviewed
 140-355 2.22e-09

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 58.18  E-value: 2.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 140 NTTLARMKRSITI--LGKKEGEEVDFAKLMYPAMQVADIFAGGFHFSHAGIDQrKANV-IARDVAKqlkfsqlKINNKpi 216
Cdd:PRK00927   96 ITPLGELERMTQFkdKSAKQKENVSAGLFTYPVLMAADILLYKADLVPVGEDQ-KQHLeLTRDIAR-------RFNNL-- 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423 217 kpvaahthllaglnKPAVWPVPEGFNKGELQTSM-------KMSKSKPD--SAVFIHDSEEEIRRKIKKA---------- 277
Cdd:PRK00927  166 --------------YGEVFPVPEPLIPKVGARVMgldgptkKMSKSDPNdnNTINLLDDPKTIAKKIKKAvtdserlrei 231

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1277932423 278 -FCQEGEIEFNPIIDWveYLIFSREEkitierqpehggnlkisgIDELKKIFKNKELHPEDLKKFTADYLIELLKPARE 355
Cdd:PRK00927  232 rYDLPNKPEVSNLLTI--YSALSGES------------------IEELEAEYEAGGKGYGDFKKDLAEAVVEFLAPIRE 290
TyrS COG0162
Tyrosyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tyrosyl-tRNA ...
 1-71 4.85e-05

Tyrosyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tyrosyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439932 [Multi-domain]  Cd Length: 409  Bit Score: 45.02  E-value: 4.85e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1277932423   1 MDIQEKinLISRQTEEIITLNDLEFLLKsGEPLKHYIGFEISGK-IHLGSgLICMQKIKDFADAGVKVhIFL 71
Cdd:COG0162     1 MNLLLE--LIWRGLIEQITDEELREKLA-GGPLTIYLGFDPTAPsLHLGH-LVPLMKLRRFQDLGHRP-IAL 67
PRK13354 PRK13354
tyrosyl-tRNA synthetase; Provisional
 23-146 2.04e-03

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 237360 [Multi-domain]  Cd Length: 410  Bit Score: 39.88  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423  23 LEFLLKSGEPLKHYIGFEISG-KIHLGSgLICMQKIKDFADAGVKVHIFLADYHAWINDKLGGD----LEAIKKIAVNyf 97
Cdd:PRK13354   24 LRKSLKEGKPLTLYLGFDPTApSLHIGH-LVPLMKLKRFQDAGHRPVILIGGFTGKIGDPSGKSkerkLLTDEQVQHN-- 100

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277932423  98 KEGLVAAY-KCLGGNP----------KDLNFIlasEFYRkndnywptvlDVAKNTTLARM 146
Cdd:PRK13354  101 AKTYTEQIfKLFDFEKteivnnsdwlSKLNLI---DFLR----------DYGKHFTVNRM 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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