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Conserved domains on  [gi|1277971135|gb|PIV64843|]
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sugar isomerase [bacterium (Candidatus Ratteibacteria) CG01_land_8_20_14_3_00_40_19]

Protein Classification

SIS domain-containing protein( domain architecture ID 10141873)

SIS (sugar isomerase) domain-containing protein similar to Mycobacterium gastri 6-phospho-3-hexuloisomerase (PHI, EC 5.3.1.27) that catalyzes the isomerization between 3-hexulose 6-phosphate and fructose 6-phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SIS_PHI cd05005
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ...
 8-182 3.46e-65

Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.


:

Pssm-ID: 240138 [Multi-domain]  Cd Length: 179  Bit Score: 197.80  E-value: 3.46e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135   8 EKVIGEIGNVLSRAKEEEIKELVEALLSARKVFVVGAGRSMLMMEAFAKRLGHLKIEVYVAGEIIEPPLTKKDLLVIASG 87
Cdd:cd05005     5 SLILEEIENVADKIDEEELDKLISAILNAKRIFVYGAGRSGLVAKAFAMRLMHLGLNVYVVGETTTPAIGPGDLLIAISG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135  88 SGESILPLEIGKIAKRIGAKVALITARKKSRIARIADMLVYLPGSTKLGPGKKIKSVQPLGNLFEQSLLLFCDIVAMLIQ 167
Cdd:cd05005    85 SGETSSVVNAAEKAKKAGAKVVLITSNPDSPLAKLADVVVVIPAATKDDHGGEHKSIQPLGTLFEQSALVFLDAVIAKLM 164

                         170
                  ....*....|....*
gi 1277971135 168 KRKGLSNQDLLKYHS 182
Cdd:cd05005   165 EELGVSEEEMKKRHA 179
 
Name Accession Description Interval E-value
SIS_PHI cd05005
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ...
 8-182 3.46e-65

Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.


Pssm-ID: 240138 [Multi-domain]  Cd Length: 179  Bit Score: 197.80  E-value: 3.46e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135   8 EKVIGEIGNVLSRAKEEEIKELVEALLSARKVFVVGAGRSMLMMEAFAKRLGHLKIEVYVAGEIIEPPLTKKDLLVIASG 87
Cdd:cd05005     5 SLILEEIENVADKIDEEELDKLISAILNAKRIFVYGAGRSGLVAKAFAMRLMHLGLNVYVVGETTTPAIGPGDLLIAISG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135  88 SGESILPLEIGKIAKRIGAKVALITARKKSRIARIADMLVYLPGSTKLGPGKKIKSVQPLGNLFEQSLLLFCDIVAMLIQ 167
Cdd:cd05005    85 SGETSSVVNAAEKAKKAGAKVVLITSNPDSPLAKLADVVVVIPAATKDDHGGEHKSIQPLGTLFEQSALVFLDAVIAKLM 164

                         170
                  ....*....|....*
gi 1277971135 168 KRKGLSNQDLLKYHS 182
Cdd:cd05005   165 EELGVSEEEMKKRHA 179
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 5-130 5.54e-17

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 76.50  E-value: 5.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135   5 NIKEKVIGEIGNVLSRAKEEEIKELVEALLSARKVFVVGAGRSMLMMEAFAKRLGHLKIEVYV----AGEIIE--PPLTK 78
Cdd:COG1737   103 KVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVVLldgdGHLQAEsaALLGP 182

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1277971135  79 KDLLVIASGSGESILPLEIGKIAKRIGAKVALITARKKSRIARIADMLVYLP 130
Cdd:COG1737   183 GDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVP 234
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 33-130 1.97e-09

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 53.07  E-value: 1.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135  33 LLSARKVFVVGAGRSMLMMEAFAKRLGHLK---IEVYVAGEIIE---PPLTKKDLLVIASGSGESILPLEIGKIAKRIGA 106
Cdd:pfam01380   2 LAKAKRIFVIGRGTSYAIALELALKFEEIGykvVEVELASELRHgvlALVDEDDLVIAISYSGETKDLLAAAELAKARGA 81

                          90       100
                  ....*....|....*....|....
gi 1277971135 107 KVALITARKKSRIARIADMLVYLP 130
Cdd:pfam01380  82 KIIAITDSPGSPLAREADHVLYIN 105
PRK00331 PRK00331
isomerizing glutamine--fructose-6-phosphate transaminase;
2-129 8.31e-08

isomerizing glutamine--fructose-6-phosphate transaminase;


Pssm-ID: 234729 [Multi-domain]  Cd Length: 604  Bit Score: 51.20  E-value: 8.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135   2 DFFNIKEkvIGE----IGNVLSR--AKEEEIKELVEALLSARKVFVVGAGRS----ML---MMEAFAKrlghLKIEVYVA 68
Cdd:PRK00331  251 RHFMLKE--IYEqpeaIRDTLEGrlDELGEGELADEDLKKIDRIYIVACGTSyhagLVakyLIESLAG----IPVEVEIA 324

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1277971135  69 GE--IIEPPLTKKDLLVIASGSGESILPLEIGKIAKRIGAKVALITARKKSRIARIADMLVYL 129
Cdd:PRK00331  325 SEfrYRDPVLSPKTLVIAISQSGETADTLAALRLAKELGAKTLAICNVPGSTIARESDAVLYT 387
 
Name Accession Description Interval E-value
SIS_PHI cd05005
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ...
 8-182 3.46e-65

Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.


Pssm-ID: 240138 [Multi-domain]  Cd Length: 179  Bit Score: 197.80  E-value: 3.46e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135   8 EKVIGEIGNVLSRAKEEEIKELVEALLSARKVFVVGAGRSMLMMEAFAKRLGHLKIEVYVAGEIIEPPLTKKDLLVIASG 87
Cdd:cd05005     5 SLILEEIENVADKIDEEELDKLISAILNAKRIFVYGAGRSGLVAKAFAMRLMHLGLNVYVVGETTTPAIGPGDLLIAISG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135  88 SGESILPLEIGKIAKRIGAKVALITARKKSRIARIADMLVYLPGSTKLGPGKKIKSVQPLGNLFEQSLLLFCDIVAMLIQ 167
Cdd:cd05005    85 SGETSSVVNAAEKAKKAGAKVVLITSNPDSPLAKLADVVVVIPAATKDDHGGEHKSIQPLGTLFEQSALVFLDAVIAKLM 164

                         170
                  ....*....|....*
gi 1277971135 168 KRKGLSNQDLLKYHS 182
Cdd:cd05005   165 EELGVSEEEMKKRHA 179
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 24-130 6.57e-19

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 78.42  E-value: 6.57e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135  24 EEIKELVEALLSARKVFVVGAGRSMLMMEAFAKRLGHLKIEVYVAG-----EIIEPPLTKKDLLVIASGSGESILPLEIG 98
Cdd:cd05013     1 EALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSdphlqLMSAANLTPGDVVIAISFSGETKETVEAA 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1277971135  99 KIAKRIGAKVALITARKKSRIARIADMLVYLP 130
Cdd:cd05013    81 EIAKERGAKVIAITDSANSPLAKLADIVLLVS 112
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 5-130 5.54e-17

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 76.50  E-value: 5.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135   5 NIKEKVIGEIGNVLSRAKEEEIKELVEALLSARKVFVVGAGRSMLMMEAFAKRLGHLKIEVYV----AGEIIE--PPLTK 78
Cdd:COG1737   103 KVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVVLldgdGHLQAEsaALLGP 182

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1277971135  79 KDLLVIASGSGESILPLEIGKIAKRIGAKVALITARKKSRIARIADMLVYLP 130
Cdd:COG1737   183 GDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVP 234
SIS_GlmS_GlmD_1 cd05008
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and ...
 38-130 1.45e-10

SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal glutaminase domain and two C-terminal SIS domains and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. The end product of the pathway is N-acetylglucosamine, which plays multiple roles in eukaryotic cells including being a building block of bacterial and fungal cell walls. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate (PGI-like activity). Glucosamine-6-phosphate deaminase (GlmD) contains two SIS domains and catalyzes the deamination and isomerization of glucosamine-6-phosphate into fructose-6-phosphate with the release of ammonia; in presence of high ammonia concentration, GlmD can catalyze the reverse reaction.


Pssm-ID: 240141 [Multi-domain]  Cd Length: 126  Bit Score: 55.97  E-value: 1.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135  38 KVFVVGAGRSM---LMMEAFAKRLGHLKIEVYVAGEII--EPPLTKKDLLVIASGSGESILPLEIGKIAKRIGAKVALIT 112
Cdd:cd05008     1 RILIVGCGTSYhaaLVAKYLLERLAGIPVEVEAASEFRyrRPLLDEDTLVIAISQSGETADTLAALRLAKEKGAKTVAIT 80

                          90
                  ....*....|....*...
gi 1277971135 113 ARKKSRIARIADMLVYLP 130
Cdd:cd05008    81 NVVGSTLAREADYVLYLR 98
AgaS COG2222
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ...
 18-136 2.24e-10

Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441824 [Multi-domain]  Cd Length: 336  Bit Score: 58.37  E-value: 2.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135  18 LSRAKEEEIKELVEALLSA--RKVFVVGAGRSMLMMEAFA---KRLGHLKIEVYVAGEII---EPPLTKKDLLVIASGSG 89
Cdd:COG2222    14 ALAALAAAIAALLARLRAKppRRVVLVGAGSSDHAAQAAAyllERLLGIPVAALAPSELVvypAYLKLEGTLVVAISRSG 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1277971135  90 ESILPLEIGKIAKRIGAKVALITARKKSRIARIADMLVYLPGSTKLG 136
Cdd:COG2222    94 NSPEVVAALELAKARGARTLAITNNPDSPLAEAADRVLPLPAGPEKS 140
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 33-130 1.97e-09

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 53.07  E-value: 1.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135  33 LLSARKVFVVGAGRSMLMMEAFAKRLGHLK---IEVYVAGEIIE---PPLTKKDLLVIASGSGESILPLEIGKIAKRIGA 106
Cdd:pfam01380   2 LAKAKRIFVIGRGTSYAIALELALKFEEIGykvVEVELASELRHgvlALVDEDDLVIAISYSGETKDLLAAAELAKARGA 81

                          90       100
                  ....*....|....*....|....
gi 1277971135 107 KVALITARKKSRIARIADMLVYLP 130
Cdd:pfam01380  82 KIIAITDSPGSPLAREADHVLYIN 105
SIS_1 cd05710
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar ...
 39-128 6.13e-09

A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240214 [Multi-domain]  Cd Length: 120  Bit Score: 51.81  E-value: 6.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135  39 VFVVGAGRSMLMM---EAFAKRLGHLKIEVYVAGEII---EPPLTKKDLLVIASGSG---ESIlplEIGKIAKRIGAKVA 109
Cdd:cd05710     2 VFFVGCGGSLADMypaKYFLKKESKLPVFVYNAAEFLhtgPKRLTEKSVVILASHSGntkETV---AAAKFAKEKGATVI 78

                          90
                  ....*....|....*....
gi 1277971135 110 LITARKKSRIARIADMLVY 128
Cdd:cd05710    79 GLTDDEDSPLAKLADYVIV 97
PRK00331 PRK00331
isomerizing glutamine--fructose-6-phosphate transaminase;
2-129 8.31e-08

isomerizing glutamine--fructose-6-phosphate transaminase;


Pssm-ID: 234729 [Multi-domain]  Cd Length: 604  Bit Score: 51.20  E-value: 8.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135   2 DFFNIKEkvIGE----IGNVLSR--AKEEEIKELVEALLSARKVFVVGAGRS----ML---MMEAFAKrlghLKIEVYVA 68
Cdd:PRK00331  251 RHFMLKE--IYEqpeaIRDTLEGrlDELGEGELADEDLKKIDRIYIVACGTSyhagLVakyLIESLAG----IPVEVEIA 324

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1277971135  69 GE--IIEPPLTKKDLLVIASGSGESILPLEIGKIAKRIGAKVALITARKKSRIARIADMLVYL 129
Cdd:PRK00331  325 SEfrYRDPVLSPKTLVIAISQSGETADTLAALRLAKELGAKTLAICNVPGSTIARESDAVLYT 387
GlmS COG0449
Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase ...
 20-129 1.06e-07

Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440218 [Multi-domain]  Cd Length: 610  Bit Score: 50.78  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135  20 RAKEEEIKELVEALLSARKVFVVGAGRSM-------LMMEAFAKrlghLKIEVYVAGEII--EPPLTKKDLLVIASGSGE 90
Cdd:COG0449   278 RVVLDELNLAAEDLRNIDRIYIVACGTSYhaglvgkYLIEELAR----IPVEVEIASEFRyrDPVVDPGTLVIAISQSGE 353

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1277971135  91 SILPLEIGKIAKRIGAKVALITARKKSRIARIADMLVYL 129
Cdd:COG0449   354 TADTLAALREAKEKGAKVLAICNVVGSTIARESDAVLYT 392
SIS_2 pfam13580
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 11-112 2.28e-07

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 433326 [Multi-domain]  Cd Length: 138  Bit Score: 47.59  E-value: 2.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135  11 IGEIGNVLSRAKEEEIKE-------LVEALLSARKVFVVGAGRSMLMMEAFAKRLGHL---------------------- 61
Cdd:pfam13580   3 LDEVRALLERVVETQADAiekaadlIAASLANGGKVYAFGTGHSAAPAEELFARAGGLagfepillpalalhtdasatis 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1277971135  62 -KIE-VYVAGEIIE--PPLTKKDLLVIASGSGESILPLEIGKIAKRIGAKVALIT 112
Cdd:pfam13580  83 tALErDEGYARQILalYPGRPGDVLIVISNSGINAVPVEAALEAKERGMKVIALT 137
SIS_GmhA cd05006
Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose ...
 4-130 2.04e-06

Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of gram-negative bacteria inner core lipopolysaccharide precursor, L-glycero-D-mannoheptose (Gmh).


Pssm-ID: 240139 [Multi-domain]  Cd Length: 177  Bit Score: 45.96  E-value: 2.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135   4 FNIKEKVIGEIGNVLSRAKEEEIKELVEALLSARKVFVVGAGRS----MLMMEAFAKRLGH----LKI------------ 63
Cdd:cd05006     1 FQESIQLKEALLELLAEAIEQAAQLLAEALLNGGKILICGNGGSaadaQHFAAELVKRFEKerpgLPAialttdtsilta 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1277971135  64 --------EVYVagEIIEPPLTKKDLLVIASGSGESILPLEIGKIAKRIGAKVALITARKKSRIARIADMLVYLP 130
Cdd:cd05006    81 iandygyeEVFS--RQVEALGQPGDVLIGISTSGNSPNVLKALEAAKERGMKTIALTGRDGGKLLELADIEIHVP 153
PRK02947 PRK02947
sugar isomerase domain-containing protein;
5-118 2.56e-06

sugar isomerase domain-containing protein;


Pssm-ID: 179510 [Multi-domain]  Cd Length: 246  Bit Score: 46.02  E-value: 2.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135   5 NIKEKVIGEIGNVLSRAKEEEIKEL-------VEALLSARKVFVVGAGRSMLM-MEAF--------AKRLGHLKI---EV 65
Cdd:PRK02947    2 DMIDEYFDAVIELLERVRETQAEAIekaadliADSIRNGGLIYVFGTGHSHILaEEVFyragglapVNPILEPSLmlhEG 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1277971135  66 YVAGEIIE------------PPLTKKDLLVIASGSGESILPLEIGKIAKRIGAKVALITARKKSR 118
Cdd:PRK02947   82 AVASSYLErvegyakaildrYDIRPGDVLIVVSNSGRNPVPIEMALEAKERGAKVIAVTSLAYSA 146
GutQ COG0794
D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall ...
 76-181 1.25e-05

D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440557 [Multi-domain]  Cd Length: 317  Bit Score: 44.20  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135  76 LTKKDLLVIASGSGES-----ILPLeigkiAKRIGAKVALITARKKSRIARIADMLVYLPgstklgpgkKIKSVQPLGnl 150
Cdd:COG0794    89 ITPGDVVIAISNSGETeellaLLPL-----LKRLGVPLIAITGNPDSTLARAADVVLDLP---------VEREACPLN-- 152

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1277971135 151 feqsL---------LLFCDIVAMLIQKRKGLSNQDLLKYH 181
Cdd:COG0794   153 ----LapttsttatLALGDALAVALLEARGFTAEDFARFH 188
SIS_Etherase cd05007
N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ...
 76-138 2.88e-04

N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid carries a unique D-lactyl ether substituent at the C3 position. The etherase catalyzes the cleavage of the lactyl ether bond of N-acetylmuramic acid 6-phosphate.


Pssm-ID: 240140 [Multi-domain]  Cd Length: 257  Bit Score: 40.20  E-value: 2.88e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135  76 LTKKDLLVIASGSGESILPLEIGKIAKRIGAKVALITARKKSRIARIADMLVYLP-------GSTKLGPG 138
Cdd:cd05007   116 LTERDVVIGIAASGRTPYVLGALRYARARGALTIGIACNPGSPLLQLADIAIALItgpevvaGSTRLKAG 185
SIS cd04795
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 39-113 4.11e-04

SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240112 [Multi-domain]  Cd Length: 87  Bit Score: 37.74  E-value: 4.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1277971135  39 VFVVGAGRSMLMMEAFAKRLGHL-KIEVYVAGEIIEPP------LTKKDLLVIASGSGESILPLEIGKIAKRIGAKVALI 111
Cdd:cd04795     1 IFVIGIGGSGAIAAYFALELLELtGIEVVALIATELEHasllslLRKGDVVIALSYSGRTEELLAALEIAKELGIPVIAI 80


                  ..
gi 1277971135 112 TA 113
Cdd:cd04795    81 TD 82
PRK11337 PRK11337
MurR/RpiR family transcriptional regulator;
76-136 2.16e-03

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183089 [Multi-domain]  Cd Length: 292  Bit Score: 37.82  E-value: 2.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1277971135  76 LTKKDLLVIASGSGESILPLEIGKIAKRIGAKVALITARKKSRIARIADMLV--YLPGSTKLG 136
Cdd:PRK11337  185 LQEGDVVLVVSHSGRTSDVIEAVELAKKNGAKIICITNSYHSPIAKLADYVIcsTAQGSPLLG 247
murQ PRK05441
N-acetylmuramic acid-6-phosphate etherase; Reviewed
 76-138 9.30e-03

N-acetylmuramic acid-6-phosphate etherase; Reviewed


Pssm-ID: 235467 [Multi-domain]  Cd Length: 299  Bit Score: 35.91  E-value: 9.30e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1277971135  76 LTKKDLLVIASGSGESilPLEIG--KIAKRIGAKVALITARKKSRIARIADMLVYLP-------GSTKLGPG 138
Cdd:PRK05441  129 LTAKDVVVGIAASGRT--PYVIGalEYARERGALTIGISCNPGSPLSKEADIAIEVVvgpevltGSTRMKAG 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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