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Conserved domains on  [gi|1278529015|gb|PJA47796.1|]
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hypothetical protein CO172_00030 [Candidatus Uhrbacteria bacterium CG_4_9_14_3_um_filter_36_7]

Protein Classification

F0F1 ATP synthase subunit A( domain architecture ID 10001246)

F0F1 ATP synthase subunit A is part of the membrane proton channel of the F-type ATPase that produces ATP from ADP in the presence of a proton gradient across the membrane; it plays a direct role in the translocation of protons across the membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AtpB COG0356
FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP ...
 21-258 7.01e-43

FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit a is part of the Pathway/BioSystem: FoF1-type ATP synthase


:

Pssm-ID: 440125 [Multi-domain]  Cd Length: 212  Bit Score: 145.22  E-value: 7.01e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  21 NSILTAWIVIAIFLIGGLLIRSKANLQPKGIIAFFDWLIESALREVEKIVGdrERAKRFFPICGSLFFFILISNWMGLLP 100
Cdd:COG0356     1 DTVLMSWLAMLLLLLLFLLATRKLKLVPGGLQNFVEMLVEFVRNQVKDTIG--KKGRKFAPLLLTLFLFILVSNLLGLIP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 101 GvgsiginalhagkieliplFRPATSDLNFTLAIAAFSVLATHFFGILAIGFITHVSKFLNirgiilafrqGPMQVIVsi 180
Cdd:COG0356    79 G-------------------LFPPTADINVTLALALIVFVLVHYYGIKKKGLGGYLKHLFF----------PPFPWLA-- 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 181 veFFVGLIESVGEVAKMVSLALRLFGNIFAGEVLLTVMYSLV--------SFFAPLPFIFLELLVGAIQATVFAILVLVF 252
Cdd:COG0356   128 --PLMLPIEIISELARPLSLSLRLFGNMFAGHIILLLLAGLApflllgvlSLLLPVAWTAFELLVGFLQAYIFTMLTAVY 205


                  ....*.
gi 1278529015 253 LKSSTE 258
Cdd:COG0356   206 ISLAVE 211
 
Name Accession Description Interval E-value
AtpB COG0356
FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP ...
 21-258 7.01e-43

FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit a is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440125 [Multi-domain]  Cd Length: 212  Bit Score: 145.22  E-value: 7.01e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  21 NSILTAWIVIAIFLIGGLLIRSKANLQPKGIIAFFDWLIESALREVEKIVGdrERAKRFFPICGSLFFFILISNWMGLLP 100
Cdd:COG0356     1 DTVLMSWLAMLLLLLLFLLATRKLKLVPGGLQNFVEMLVEFVRNQVKDTIG--KKGRKFAPLLLTLFLFILVSNLLGLIP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 101 GvgsiginalhagkieliplFRPATSDLNFTLAIAAFSVLATHFFGILAIGFITHVSKFLNirgiilafrqGPMQVIVsi 180
Cdd:COG0356    79 G-------------------LFPPTADINVTLALALIVFVLVHYYGIKKKGLGGYLKHLFF----------PPFPWLA-- 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 181 veFFVGLIESVGEVAKMVSLALRLFGNIFAGEVLLTVMYSLV--------SFFAPLPFIFLELLVGAIQATVFAILVLVF 252
Cdd:COG0356   128 --PLMLPIEIISELARPLSLSLRLFGNMFAGHIILLLLAGLApflllgvlSLLLPVAWTAFELLVGFLQAYIFTMLTAVY 205


                  ....*.
gi 1278529015 253 LKSSTE 258
Cdd:COG0356   206 ISLAVE 211
PRK05815 PRK05815
F0F1 ATP synthase subunit A; Validated
 12-260 7.41e-35

F0F1 ATP synthase subunit A; Validated


Pssm-ID: 235617  Cd Length: 227  Bit Score: 124.91  E-value: 7.41e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  12 FQIGNFPVTNSILTAWIVIAIFLIGGLLIRSKANLQPKGIIAFFDWLIESALREVEKIVGDREraKRFFPICGSLFFFIL 91
Cdd:PRK05815    7 IGFGGFNFDSLLLSVLLGVLILLLFALVATRKLSGVPGGLQNFVEMIVEFVRGQVKDNIGGKG--KKFAPLAFTLFLFIL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  92 ISNWMGLLPGvgsiginalhagkielipLFRPATSDLNFTLAIAAFSVLATHFFGILAIGFITHVSKFLNIRGIILAFrq 171
Cdd:PRK05815   85 LMNLLGLIPY------------------LLFPPTADINVTLALALIVFVLVIYYGIKKKGLGGYLKEFYLQPHPLLLP-- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 172 gpmqvivsiveffvglIESVGEVAKMVSLALRLFGNIFAGEVLLTVMYSL---------VSFFAPLPFIFLELLVGAIQA 242
Cdd:PRK05815  145 ----------------IEIISEFSRPISLSLRLFGNMLAGELILALIALLggaglllalAPLILPVAWTIFEIFVGTLQA 208

                         250
                  ....*....|....*...
gi 1278529015 243 TVFAILVLVFLKSSTEGH 260
Cdd:PRK05815  209 YIFMMLTIVYISMAVEEE 226
ATP-synt_A pfam00119
ATP synthase A chain;
23-254 3.28e-32

ATP synthase A chain;


Pssm-ID: 459679 [Multi-domain]  Cd Length: 216  Bit Score: 117.98  E-value: 3.28e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  23 ILTAWIVIAI-FLIGGLLIRSKANLQPKGIIAFFDWLIESALREVEKIVGDRErAKRFFPICGSLFFFILISNWMGLLPG 101
Cdd:pfam00119   1 LLMSLIVALIlLLFLLLATRKTKKLVPGRLQNFVEMLVEFVDNIVKDNIGKKK-GRKFFPLLLTLFFFILVSNLLGLIPK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 102 VgsiginalhagkieliPLFRPATSDLNFTLAIAAFSVLATHFFGILAIGFITHVSKFLNirgiilafrqgpMQVIVSIV 181
Cdd:pfam00119  80 S----------------PGGFTVTADINVTLALALIVFLLVHYYGIKKHGLGGYFKKLFV------------PPVPLPLV 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 182 EFFVgLIESVGEVAKMVSLALRLFGNIFAGEVLLTVMYSL-------------VSFFAPLPFIFLELLVGAIQATVFAIL 248
Cdd:pfam00119 132 PLLL-PIEIISEFARPVSLSLRLFGNMLAGHLLLLLLAGLifallsagfllgvIPPLLGVAWTLFELLVAFIQAYVFTML 210


                  ....*.
gi 1278529015 249 VLVFLK 254
Cdd:pfam00119 211 TAVYIS 216
ATP-synt_Fo_a_6 cd00310
ATP synthase Fo complex, subunit 6 (eukaryotes) and subunit a (prokaryotes); Bacterial forms ...
 76-254 3.02e-27

ATP synthase Fo complex, subunit 6 (eukaryotes) and subunit a (prokaryotes); Bacterial forms are designated as ATP synthase, Fo complex, subunit a; eukaryotic (chloroplast and mitochondrial) forms are designated as ATP synthase, Fo complex, subunit 6. The F-ATP synthases (also called FoF1-ATPases) consist of two structural domains: F1 (factor one) complex containing the soluble catalytic core, and Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. F-ATP synthase has also been found in the archaea Methanosarcina acetivorans. F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis.


Pssm-ID: 349411 [Multi-domain]  Cd Length: 156  Bit Score: 102.86  E-value: 3.02e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  76 AKRFFPICGSLFFFILISNWMGLlpgvgsiginalhagkielIPLFRPATSDLNFTLAIAAFSVLATHFFGILAIGFith 155
Cdd:cd00310     1 GKKYLPLLGTLFLFILFSNLLGL-------------------IPYSFTPTSHLNVTLALALIVFLGVHILGIKKHGL--- 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 156 vskflniRGIILAFRQGPMQVIVsiveFFVGLIESVGEVAKMVSLALRLFGNIFAGEVLLTVMYSLV----------SFF 225
Cdd:cd00310    59 -------GFFLHFLPPGTPLPLA----PLMVPIELISELIRPLSLSVRLFANMFAGHLLLALLSGLVpsllssvgllPLL 127

                         170       180
                  ....*....|....*....|....*....
gi 1278529015 226 APLPFIFLELLVGAIQATVFAILVLVFLK 254
Cdd:cd00310   128 LPVALTLLELFVAFIQAYVFTLLTAVYIS 156
ATP_synt_6_or_A TIGR01131
ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Bacterial forms should be ...
 12-256 1.85e-19

ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Bacterial forms should be designated ATP synthase, F0 subunit A; eukaryotic (chloroplast and mitochondrial) forms should be designated ATP synthase, F0 subunit 6. The F1/F0 ATP synthase is a multisubunit, membrane associated enzyme found in bacteria and mitochondria and chloroplast. This enzyme is principally involved in the synthesis of ATP from ADP and inorganic phosphate by coupling the energy derived from the proton electrochemical gradient across the biological membrane. A brief description of this multisubunit enzyme complex: F1 and F0 represent two major clusters of subunits. Individual subunits in each of these clusters are named differently in prokaryotes and in organelles e.g., mitochondria and chloroplast. The bacterial equivalent of subunit 6 is named subunit 'A'. It has been shown that proton is conducted though this subunit. Typically, deprotonation and reprotonation of the acidic amino acid side-chains are implicated in the process. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273458  Cd Length: 226  Bit Score: 84.18  E-value: 1.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  12 FQIGNFPVTNSILTAWIVIAIFLIGGLLIRSKANLQPKGIIAFFDWLIESALREVEKIVGDREraKRFFPICGSLFFFIL 91
Cdd:TIGR01131   5 FDISPITLFSLTLLSLILLLSLLIFLISSSLSRWLIPSRWQNLMESIYEFVLSIVKSQIGGKK--GKFFPLIFTLFLFIL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  92 ISNWMGLLPGVGSIginalhagkieliplfrpaTSDLNFTLAIAaFSVlathFFGILAIGFITHVSKFLNIrgiiLAfrq 171
Cdd:TIGR01131  83 ISNLLGLIPYSFTP-------------------TSHLSFTLGLA-LPL----WLGLTISGFRKHPKGFLAH----LV--- 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 172 gPMQVIVSIVEFFVgLIESVGEVAKMVSLALRLFGNIFAGEVLLTVMYSLVSFFAPLPF-----------IFLELLVGAI 240
Cdd:TIGR01131 132 -PSGTPLPLIPFLV-IIETISYLARPISLSVRLFANISAGHLLLTLLSGLLFSLMSSAIfallllilvalIILEIFVAFI 209

                         250
                  ....*....|....*.
gi 1278529015 241 QATVFAILVLVFLKSS 256
Cdd:TIGR01131 210 QAYVFTLLTCLYLNDA 225
 
Name Accession Description Interval E-value
AtpB COG0356
FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP ...
 21-258 7.01e-43

FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit a is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440125 [Multi-domain]  Cd Length: 212  Bit Score: 145.22  E-value: 7.01e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  21 NSILTAWIVIAIFLIGGLLIRSKANLQPKGIIAFFDWLIESALREVEKIVGdrERAKRFFPICGSLFFFILISNWMGLLP 100
Cdd:COG0356     1 DTVLMSWLAMLLLLLLFLLATRKLKLVPGGLQNFVEMLVEFVRNQVKDTIG--KKGRKFAPLLLTLFLFILVSNLLGLIP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 101 GvgsiginalhagkieliplFRPATSDLNFTLAIAAFSVLATHFFGILAIGFITHVSKFLNirgiilafrqGPMQVIVsi 180
Cdd:COG0356    79 G-------------------LFPPTADINVTLALALIVFVLVHYYGIKKKGLGGYLKHLFF----------PPFPWLA-- 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 181 veFFVGLIESVGEVAKMVSLALRLFGNIFAGEVLLTVMYSLV--------SFFAPLPFIFLELLVGAIQATVFAILVLVF 252
Cdd:COG0356   128 --PLMLPIEIISELARPLSLSLRLFGNMFAGHIILLLLAGLApflllgvlSLLLPVAWTAFELLVGFLQAYIFTMLTAVY 205


                  ....*.
gi 1278529015 253 LKSSTE 258
Cdd:COG0356   206 ISLAVE 211
PRK05815 PRK05815
F0F1 ATP synthase subunit A; Validated
 12-260 7.41e-35

F0F1 ATP synthase subunit A; Validated


Pssm-ID: 235617  Cd Length: 227  Bit Score: 124.91  E-value: 7.41e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  12 FQIGNFPVTNSILTAWIVIAIFLIGGLLIRSKANLQPKGIIAFFDWLIESALREVEKIVGDREraKRFFPICGSLFFFIL 91
Cdd:PRK05815    7 IGFGGFNFDSLLLSVLLGVLILLLFALVATRKLSGVPGGLQNFVEMIVEFVRGQVKDNIGGKG--KKFAPLAFTLFLFIL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  92 ISNWMGLLPGvgsiginalhagkielipLFRPATSDLNFTLAIAAFSVLATHFFGILAIGFITHVSKFLNIRGIILAFrq 171
Cdd:PRK05815   85 LMNLLGLIPY------------------LLFPPTADINVTLALALIVFVLVIYYGIKKKGLGGYLKEFYLQPHPLLLP-- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 172 gpmqvivsiveffvglIESVGEVAKMVSLALRLFGNIFAGEVLLTVMYSL---------VSFFAPLPFIFLELLVGAIQA 242
Cdd:PRK05815  145 ----------------IEIISEFSRPISLSLRLFGNMLAGELILALIALLggaglllalAPLILPVAWTIFEIFVGTLQA 208

                         250
                  ....*....|....*...
gi 1278529015 243 TVFAILVLVFLKSSTEGH 260
Cdd:PRK05815  209 YIFMMLTIVYISMAVEEE 226
ATP-synt_A pfam00119
ATP synthase A chain;
23-254 3.28e-32

ATP synthase A chain;


Pssm-ID: 459679 [Multi-domain]  Cd Length: 216  Bit Score: 117.98  E-value: 3.28e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  23 ILTAWIVIAI-FLIGGLLIRSKANLQPKGIIAFFDWLIESALREVEKIVGDRErAKRFFPICGSLFFFILISNWMGLLPG 101
Cdd:pfam00119   1 LLMSLIVALIlLLFLLLATRKTKKLVPGRLQNFVEMLVEFVDNIVKDNIGKKK-GRKFFPLLLTLFFFILVSNLLGLIPK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 102 VgsiginalhagkieliPLFRPATSDLNFTLAIAAFSVLATHFFGILAIGFITHVSKFLNirgiilafrqgpMQVIVSIV 181
Cdd:pfam00119  80 S----------------PGGFTVTADINVTLALALIVFLLVHYYGIKKHGLGGYFKKLFV------------PPVPLPLV 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 182 EFFVgLIESVGEVAKMVSLALRLFGNIFAGEVLLTVMYSL-------------VSFFAPLPFIFLELLVGAIQATVFAIL 248
Cdd:pfam00119 132 PLLL-PIEIISEFARPVSLSLRLFGNMLAGHLLLLLLAGLifallsagfllgvIPPLLGVAWTLFELLVAFIQAYVFTML 210


                  ....*.
gi 1278529015 249 VLVFLK 254
Cdd:pfam00119 211 TAVYIS 216
PRK13421 PRK13421
F0F1 ATP synthase subunit A; Provisional
 1-253 6.99e-28

F0F1 ATP synthase subunit A; Provisional


Pssm-ID: 237383  Cd Length: 223  Bit Score: 106.70  E-value: 6.99e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015   1 MTPISIAAEPLFQIGNFPVTNSILTAWIVIAIFLIGGLLIRSKANLQPKGIIAFFDWLIESALREVEKIVgdRERAKRFF 80
Cdd:PRK13421    1 MTASPLSTVPLFSLGPVPISAPVVVTWAIMAVLAAGSALATRRLSLAPGRLQSVLELVVTTIDAQIRDTM--QTDPAPYR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  81 PICGSLFFFILISNWMGLLPGVgsiginalhagkieliplfRPATSDLNFTLAIAAFSVLATHFFGILAIGFITHVSKFL 160
Cdd:PRK13421   79 ALIGTLFLFVLVANWSSLVPGV-------------------EPPTAHLETDAALALIVFLATIYYGVRARGVRGYLATFA 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 161 NIRGIILafrqgPMQVivsiveffvgliesVGEVAKMVSLALRLFGNIFAGEVLLTVMYSLVSFFAPLPFIFLELLVGAI 240
Cdd:PRK13421  140 EPTWVMI-----PLNL--------------VEQLTRTFSLIVRLFGNVMSGVFVIGIVLSLAGLLVPIPLMALDLLTGAV 200

                         250
                  ....*....|...
gi 1278529015 241 QATVFAILVLVFL 253
Cdd:PRK13421  201 QAYIFAVLAMVFI 213
ATP-synt_Fo_a_6 cd00310
ATP synthase Fo complex, subunit 6 (eukaryotes) and subunit a (prokaryotes); Bacterial forms ...
 76-254 3.02e-27

ATP synthase Fo complex, subunit 6 (eukaryotes) and subunit a (prokaryotes); Bacterial forms are designated as ATP synthase, Fo complex, subunit a; eukaryotic (chloroplast and mitochondrial) forms are designated as ATP synthase, Fo complex, subunit 6. The F-ATP synthases (also called FoF1-ATPases) consist of two structural domains: F1 (factor one) complex containing the soluble catalytic core, and Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. F-ATP synthase has also been found in the archaea Methanosarcina acetivorans. F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis.


Pssm-ID: 349411 [Multi-domain]  Cd Length: 156  Bit Score: 102.86  E-value: 3.02e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  76 AKRFFPICGSLFFFILISNWMGLlpgvgsiginalhagkielIPLFRPATSDLNFTLAIAAFSVLATHFFGILAIGFith 155
Cdd:cd00310     1 GKKYLPLLGTLFLFILFSNLLGL-------------------IPYSFTPTSHLNVTLALALIVFLGVHILGIKKHGL--- 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 156 vskflniRGIILAFRQGPMQVIVsiveFFVGLIESVGEVAKMVSLALRLFGNIFAGEVLLTVMYSLV----------SFF 225
Cdd:cd00310    59 -------GFFLHFLPPGTPLPLA----PLMVPIELISELIRPLSLSVRLFANMFAGHLLLALLSGLVpsllssvgllPLL 127

                         170       180
                  ....*....|....*....|....*....
gi 1278529015 226 APLPFIFLELLVGAIQATVFAILVLVFLK 254
Cdd:cd00310   128 LPVALTLLELFVAFIQAYVFTLLTAVYIS 156
PRK13420 PRK13420
F0F1 ATP synthase subunit A; Provisional
 7-267 5.91e-23

F0F1 ATP synthase subunit A; Provisional


Pssm-ID: 237382 [Multi-domain]  Cd Length: 226  Bit Score: 93.65  E-value: 5.91e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015   7 AAEPLFQIGNFPVTNSILTAWIVIAIFLIGGLLIRSKANLQP-------KGIIAFfdwlIESALREVekivgDRERAKRF 79
Cdd:PRK13420    4 LAHVLFHIGPLPITESVLTTWGIMIVLVLASWLTTRRLSLDPgrfqvalEGVVST----IEDAIKEV-----LPRHARLV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  80 FPICGSLFFFILISNWMGLLPGVGSiginalhagkieliplfrpATSDLNFTLAIAAFSVLATHFFGILAIGFITHVSKF 159
Cdd:PRK13420   75 LPFVGTLWIFILVANLIGLIPGFHS-------------------PTADLSVTAALALLVFFSVHWFGIRAEGLREYLKHY 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 160 LNIRGIILAFrqgpmqvivsiveffvgliESVGEVAKMVSLALRLFGNIFAGEVLLTVMYSLVSFFAPLPFIFLELLVGA 239
Cdd:PRK13420  136 LSPSPFLLPF-------------------HLISEITRTLALAVRLFGNIMSLELAALLVLLVAGFLVPVPILMLHIIEAL 196

                         250       260
                  ....*....|....*....|....*...
gi 1278529015 240 IQATVFAILVLVFLKSSTEGHAENEHGE 267
Cdd:PRK13420  197 VQAYIFGMLALIYIAGGIQAHELKSQGE 224
atpI CHL00046
ATP synthase CF0 A subunit
 13-248 2.39e-22

ATP synthase CF0 A subunit


Pssm-ID: 176987  Cd Length: 228  Bit Score: 92.30  E-value: 2.39e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  13 QIGNFPVTNSIL-TAWIVIAIFLIGGLLIRSKANLQPKGIIAFFDWLIEsALREVEKIVGDRERAKRFFPICGSLFFFIL 91
Cdd:CHL00046   15 QIGGFQVHGQVLiTSWVVIAILLGSALLATRNLQTIPTGGQNFFEYVLE-FIRDLAKTQIGEEEYRPWVPFIGTMFLFIF 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  92 ISNWMGllpgvgsiginALHAGKIELIPL--FRPATSDLNFTLAIAAFSVLATHFFGILAIGfITHVSKFLNIRGIILAf 169
Cdd:CHL00046   94 VSNWSG-----------ALLPWKLIELPHgeLAAPTNDINTTVALALLTSVAYFYAGLSKKG-LGYFGKYIQPTPILLP- 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1278529015 170 rqgpmqviVSIVEFFvgliesvgevAKMVSLALRLFGNIFAGEVLLTVMYSLVSFFAPLPFIFLELLVGAIQATVFAIL 248
Cdd:CHL00046  161 --------INILEDF----------TKPLSLSFRLFGNILADELVVAVLVSLVPLVVPIPVMFLGLFTSGIQALIFATL 221
ATP_synt_6_or_A TIGR01131
ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Bacterial forms should be ...
 12-256 1.85e-19

ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Bacterial forms should be designated ATP synthase, F0 subunit A; eukaryotic (chloroplast and mitochondrial) forms should be designated ATP synthase, F0 subunit 6. The F1/F0 ATP synthase is a multisubunit, membrane associated enzyme found in bacteria and mitochondria and chloroplast. This enzyme is principally involved in the synthesis of ATP from ADP and inorganic phosphate by coupling the energy derived from the proton electrochemical gradient across the biological membrane. A brief description of this multisubunit enzyme complex: F1 and F0 represent two major clusters of subunits. Individual subunits in each of these clusters are named differently in prokaryotes and in organelles e.g., mitochondria and chloroplast. The bacterial equivalent of subunit 6 is named subunit 'A'. It has been shown that proton is conducted though this subunit. Typically, deprotonation and reprotonation of the acidic amino acid side-chains are implicated in the process. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273458  Cd Length: 226  Bit Score: 84.18  E-value: 1.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  12 FQIGNFPVTNSILTAWIVIAIFLIGGLLIRSKANLQPKGIIAFFDWLIESALREVEKIVGDREraKRFFPICGSLFFFIL 91
Cdd:TIGR01131   5 FDISPITLFSLTLLSLILLLSLLIFLISSSLSRWLIPSRWQNLMESIYEFVLSIVKSQIGGKK--GKFFPLIFTLFLFIL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  92 ISNWMGLLPGVGSIginalhagkieliplfrpaTSDLNFTLAIAaFSVlathFFGILAIGFITHVSKFLNIrgiiLAfrq 171
Cdd:TIGR01131  83 ISNLLGLIPYSFTP-------------------TSHLSFTLGLA-LPL----WLGLTISGFRKHPKGFLAH----LV--- 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 172 gPMQVIVSIVEFFVgLIESVGEVAKMVSLALRLFGNIFAGEVLLTVMYSLVSFFAPLPF-----------IFLELLVGAI 240
Cdd:TIGR01131 132 -PSGTPLPLIPFLV-IIETISYLARPISLSVRLFANISAGHLLLTLLSGLLFSLMSSAIfallllilvalIILEIFVAFI 209

                         250
                  ....*....|....*.
gi 1278529015 241 QATVFAILVLVFLKSS 256
Cdd:TIGR01131 210 QAYVFTLLTCLYLNDA 225
PRK13419 PRK13419
F0F1 ATP synthase subunit A; Provisional
 3-267 8.29e-11

F0F1 ATP synthase subunit A; Provisional


Pssm-ID: 237381  Cd Length: 342  Bit Score: 61.30  E-value: 8.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015   3 PISIAAEPLFQIGNF--PVTNSILTAWIVIAIFLIGGLLIRSK-----ANLQPKGIIAFFDWLIESALREVEKI-VGdrE 74
Cdd:PRK13419   88 PFGEVHLPKLVVGGFdiSITKHVVMMWIASAILLVVFLAAGRKykkmtKSQAPKGLANAMEALVEFIRLDVAKSnIG--H 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  75 RAKRFFPICGSLFFFILISNWMGLLPGVGSiginalhagkieliplfrpATSDLNFTLAIAAFSVLATHFFGILAI---G 151
Cdd:PRK13419  166 GYEKFLPYLLTVFFFILVCNLLGLVPYGAT-------------------ATGNINVTLTLAVFTFFITQYAAIKAHgikG 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 152 FITHVSkflnirgiilAFRQGPMQVIVSIVEFfvgliesVGEVAKMVSLALRLFGNIFAGEV----LLTVMYSL----VS 223
Cdd:PRK13419  227 YLAHLT----------GGTHWSLWIIMIPIEF-------IGLFTKPFALTVRLFANMTAGHIvilsLIFISFILksyiVA 289

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1278529015 224 FFAPLPF-IF---LELLVGAIQATVFAILVLVF--LKSSTEGHAENEHGE 267
Cdd:PRK13419  290 VAVSVPFaIFiylLELFVAFLQAYIFTMLSALFigLATAHEGHDEEHAEA 339
ATP6 MTH00157
ATP synthase F0 subunit 6; Provisional
 85-249 1.95e-05

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 214441  Cd Length: 223  Bit Score: 44.77  E-value: 1.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  85 SLFFFILISNWMGLLPGVGSiginalhagkieliplfrpATSDLNFTLAIAAfsvlaTHFFGILAIGFITHVSKFLnirg 164
Cdd:MTH00157   74 SLFSFILFNNFLGLFPYIFT-------------------STSHLSLTLSLAL-----PLWLSFMLFGWINNTNHMF---- 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 165 iILAFRQG-PMQVIvsiveFFVGLIESVGEVAKMVSLALRLFGNIFAGEVLLTVMYSLVSFFAPLPFIF----------L 233
Cdd:MTH00157  126 -AHLVPQGtPPILM-----PFMVLIETISNLIRPGTLAVRLAANMIAGHLLLTLLGNTGPSLSSMILSIliliqillliL 199

                         170
                  ....*....|....*.
gi 1278529015 234 ELLVGAIQATVFAILV 249
Cdd:MTH00157  200 ESAVAIIQSYVFSVLS 215
PRK13417 PRK13417
F0F1 ATP synthase subunit A; Provisional
 85-260 4.11e-05

F0F1 ATP synthase subunit A; Provisional


Pssm-ID: 237380  Cd Length: 352  Bit Score: 44.11  E-value: 4.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  85 SLFFFILISNWMGLLPGVGSIGINALHAGKI----------ELIPLFRPATSDLNFTLAIAAFSVLAT-HFFGILAIGFI 153
Cdd:PRK13417  163 TLFFFILFCNLMGLVPSVGELTVVASDYGGLvalgvmdhtpHALPTFAKVWSGITVTGDISVTMTLALlTMFLIYGAGFS 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 154 THVSKFLN---IRGIILafrqgPMQVIVSIVEFFvgliesVGEVAKMVSLALRLFGNIFAGEVLLTVMY----------- 219
Cdd:PRK13417  243 YQGPKFIWhsvPNGVPL-----LLYPIMWPLEFI------VSPMAKTFALTVRLLANMTAGHVIILALMgfifqfqswgi 311

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1278529015 220 SLVSFFAPLPFIFLELLVGAIQATVFAILVLVFLKSSTEGH 260
Cdd:PRK13417  312 VPVSVIGSGLIYVLEIFVAFLQAYIFVLLTSLFVGLSMHRH 352
ATP6 MTH00175
ATP synthase F0 subunit 6; Provisional
 77-260 7.57e-05

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 177228  Cd Length: 244  Bit Score: 43.07  E-value: 7.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  77 KRFFPICGSLFFFILISNWMGLLPGVgsiginalhagkieliplFRPATSdlnftlAIAAFSVLATHFFGILAIGFITHV 156
Cdd:MTH00175   80 QKYFPFILSLFLFIAILNILGLFPYV------------------FTPTAH------IIITFGLSLSIIIAVTLLGFLTFK 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 157 SKFLNIRGiilafrqgPMQVIVSIVEFFVgLIESVGEVAKMVSLALRLFGNIFAGEVLLTVMYSLV-----------SFF 225
Cdd:MTH00175  136 WNFLSILM--------PGGAPLVLAPFLV-LIETLSYLIRAISLGVRLAANISAGHLLFAILSGFAfnmlsngliilSLF 206

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1278529015 226 APLPFIF---LELLVGAIQATVFAILVLVFLKSSTEGH 260
Cdd:MTH00175  207 PMLIMIFitlLEMAVAVIQAYVFCLLTTIYLGDTIALH 244
ATP6 MTH00176
ATP synthase F0 subunit 6; Provisional
 79-248 1.72e-04

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 214449  Cd Length: 229  Bit Score: 41.94  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  79 FFPICGSLFFFILISNWMGLLPGVGSiginalhagkieliplfrpATSDLNFTLAIAAfsvlaTHFFGILAIGFITHVSK 158
Cdd:MTH00176   71 SASIIISLFILVMSLNLSGLIPYVFT-------------------STSHLVITLSLAL-----PLWLGVILSGFINNFYS 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 159 FLNIrgiiLAFRQGPMQVIvsiveFFVGLIESVGEVAKMVSLALRLFGNIFAGEVLLTVM--------------YSLVSF 224
Cdd:MTH00176  127 RLSH----LVPQGTPPLLN-----PFLVLIELVSLLIRPLTLAVRLAANLSAGHLLLGLLgaamwgllpvspliGFLLLI 197

                         170       180
                  ....*....|....*....|....
gi 1278529015 225 FAPLPFIFlELLVGAIQATVFAIL 248
Cdd:MTH00176  198 VQILYFMF-EIAVCMIQAYVFTLL 220
ATP6 MTH00179
ATP synthase F0 subunit 6; Provisional
 78-253 1.03e-03

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 177230  Cd Length: 227  Bit Score: 39.55  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015  78 RFFPICGSLFFFILISNWMGLLPGVGSIginalhagkieliplfrpaTSDLNFTLAIAAFSVLATHFFGILaIGFITHVS 157
Cdd:MTH00179   68 KWAVLFLSLMLFLLTLNLLGLLPYTFTP-------------------TTQLSLNLGLALPLWLGTVLYGLF-NQPTIALA 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278529015 158 KFLNIrgiilafrQGPMQVIVSIVeffvgLIESVGEVAKMVSLALRLFGNIFAGEVLLT-------VMYSLVSFFAPLPF 230
Cdd:MTH00179  128 HLLPE--------GTPTPLIPMLV-----WIETISLLIRPLALGVRLTANITAGHLLMHlissavfVLMNFMGMVALLTL 194

                         170       180
                  ....*....|....*....|....*....
gi 1278529015 231 I------FLELLVGAIQATVFAILVLVFL 253
Cdd:MTH00179  195 LvlflltLLEVAVAMIQAYVFVLLLSLYL 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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