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Conserved domains on  [gi|1308577848|gb|PKL80682|]
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MAG: transcriptional regulator [Candidatus Melainabacteria bacterium HGW-Melainabacteria-1]

Protein Classification

AbiEi_1 and AbiEi_4 domain-containing protein; AbiEi_1 and AbiEi_4 domain-containing protein; type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein; type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein; AbiEi_1 and AbiEi_4 domain-containing protein; type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein; AbiEi_1 and AbiEi_4 domain-containing protein; type IV toxin-antitoxin system AbiEi family antitoxin; type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein; type IV toxin-antitoxin system AbiEi family antitoxin; type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein( domain architecture ID 11475017)

AbiEi_1 and AbiEi_4 domain-containing protein; AbiEi_1 and AbiEi_4 domain-containing protein; type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein is part of the innate immunity bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection; type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein similar to AbiEi, the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection; type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein is part of the innate immunity bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection; AbiEi_1 and AbiEi_4 domain-containing protein; type IV toxin-antitoxin (TA) system AbiEi family antitoxin is the cognate antitoxin of the innate immunity bacterial abortive infection (Abi) TA system that protects bacteria from the spread of a phage infection; type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein is part of the innate immunity bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection; AbiEi_1 and AbiEi_4 domain-containing protein; type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein is part of the innate immunity bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection; type IV toxin-antitoxin (TA) system AbiEi family antitoxin is the cognate antitoxin of the innate immunity bacterial abortive infection (Abi) TA system that protects bacteria from the spread of a phage infection; type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein is part of the innate immunity bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AbiEi COG5340
Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system ...
 18-202 1.18e-53

Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system [Defense mechanisms];


:

Pssm-ID: 444124 [Multi-domain]  Cd Length: 203  Bit Score: 170.18  E-value: 1.18e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308577848  18 QGVLRPRDLAEQDLPADYLW----RLEKSGHLIRLDRGLYMRADADFSA-HISLAEVGKRIPDGVICLVSALSFHELTLQ 92
Cdd:COG5340     6 RGVFTTADARAAGLSAGISRrllsRLVKKGELERVRRGLYVLPPAEADKeHDELLIAARLVPPGYISLLSALALHGLTDQ 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308577848  93 LPHEVWIAVRPGRYHAKMEHLKLRYVHLSGASLTEGIETHRIDGVNLQVYSPAKTVADCFKFRNQLGM-ETVLQALRQGL 171
Cdd:COG5340    86 IPFTVYVAVPRRSRPIKIGGPPIRFVRFSKELFFEGVEEVKIDGGKVRVTSPERTIVDCLRYRNKIGGiDEVLEALREYL 165

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1308577848 172 EEQRFSPAELDRFACI---NRVDRVMRPYLEVLL 202
Cdd:COG5340   166 RRKKLDLDKLLEYAERlrnSAVEKRLGYLLEALL 199
 
Name Accession Description Interval E-value
AbiEi COG5340
Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system ...
 18-202 1.18e-53

Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system [Defense mechanisms];


Pssm-ID: 444124 [Multi-domain]  Cd Length: 203  Bit Score: 170.18  E-value: 1.18e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308577848  18 QGVLRPRDLAEQDLPADYLW----RLEKSGHLIRLDRGLYMRADADFSA-HISLAEVGKRIPDGVICLVSALSFHELTLQ 92
Cdd:COG5340     6 RGVFTTADARAAGLSAGISRrllsRLVKKGELERVRRGLYVLPPAEADKeHDELLIAARLVPPGYISLLSALALHGLTDQ 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308577848  93 LPHEVWIAVRPGRYHAKMEHLKLRYVHLSGASLTEGIETHRIDGVNLQVYSPAKTVADCFKFRNQLGM-ETVLQALRQGL 171
Cdd:COG5340    86 IPFTVYVAVPRRSRPIKIGGPPIRFVRFSKELFFEGVEEVKIDGGKVRVTSPERTIVDCLRYRNKIGGiDEVLEALREYL 165

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1308577848 172 EEQRFSPAELDRFACI---NRVDRVMRPYLEVLL 202
Cdd:COG5340   166 RRKKLDLDKLLEYAERlrnSAVEKRLGYLLEALL 199
AbiEi_4 pfam13338
Transcriptional regulator, AbiEi antitoxin; AbiEi_4 is the cognate antitoxin of the type IV ...
 9-56 1.82e-06

Transcriptional regulator, AbiEi antitoxin; AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.


Pssm-ID: 463849  Cd Length: 49  Bit Score: 43.30  E-value: 1.82e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1308577848   9 QKILRLARKQ-GVLRPRDLAEQDLPADYLWRLEKSGHLIRLDRGLYMRA 56
Cdd:pfam13338   1 ERLLELAARQkGIFTTADLAAAGISRRALRRLVRKGLLERLRRGVYALP 49
 
Name Accession Description Interval E-value
AbiEi COG5340
Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system ...
 18-202 1.18e-53

Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system [Defense mechanisms];


Pssm-ID: 444124 [Multi-domain]  Cd Length: 203  Bit Score: 170.18  E-value: 1.18e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308577848  18 QGVLRPRDLAEQDLPADYLW----RLEKSGHLIRLDRGLYMRADADFSA-HISLAEVGKRIPDGVICLVSALSFHELTLQ 92
Cdd:COG5340     6 RGVFTTADARAAGLSAGISRrllsRLVKKGELERVRRGLYVLPPAEADKeHDELLIAARLVPPGYISLLSALALHGLTDQ 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308577848  93 LPHEVWIAVRPGRYHAKMEHLKLRYVHLSGASLTEGIETHRIDGVNLQVYSPAKTVADCFKFRNQLGM-ETVLQALRQGL 171
Cdd:COG5340    86 IPFTVYVAVPRRSRPIKIGGPPIRFVRFSKELFFEGVEEVKIDGGKVRVTSPERTIVDCLRYRNKIGGiDEVLEALREYL 165

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1308577848 172 EEQRFSPAELDRFACI---NRVDRVMRPYLEVLL 202
Cdd:COG5340   166 RRKKLDLDKLLEYAERlrnSAVEKRLGYLLEALL 199
AbiEi_4 pfam13338
Transcriptional regulator, AbiEi antitoxin; AbiEi_4 is the cognate antitoxin of the type IV ...
 9-56 1.82e-06

Transcriptional regulator, AbiEi antitoxin; AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.


Pssm-ID: 463849  Cd Length: 49  Bit Score: 43.30  E-value: 1.82e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1308577848   9 QKILRLARKQ-GVLRPRDLAEQDLPADYLWRLEKSGHLIRLDRGLYMRA 56
Cdd:pfam13338   1 ERLLELAARQkGIFTTADLAAAGISRRALRRLVRKGLLERLRRGVYALP 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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