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Conserved domains on  [gi|1308823969|gb|PKN59539|]
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O-succinylhomoserine sulfhydrylase [Deltaproteobacteria bacterium HGW-Deltaproteobacteria-14]

Protein Classification

PLP-dependent aminotransferase family protein( domain architecture ID 139552)

PLP-dependent aminotransferase family protein may combine pyridoxal phosphate with an alpha-amino acid to form a Schiff base or aldimine intermediate, which then acts as the substrate in a reaction such as a transamination, racemization, or decarboxylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAT_I super family cl18945
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 3-392 0e+00

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


The actual alignment was detected with superfamily member PRK08133:

Pssm-ID: 450240 [Multi-domain]  Cd Length: 390  Bit Score: 540.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   3 DERRYHPKTLAVRAGSEATGYREHSEALFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAM 82
Cdd:PRK08133    1 DDDSLGFDTLAVRAGQLRSPFGEHSEALFLTSSFVFESAAEAAARFAGEEPGNIYSRFTNPTVTMFQERLAALEGAEACV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  83 GVASGMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTL 162
Cdd:PRK08133   81 ATASGMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 163 EVVDLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVrGPILSLCRTTGP 242
Cdd:PRK08133  161 ELADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKELM-EEVFGFLRTAGP 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 243 TLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDV-GSRARA 321
Cdd:PRK08133  240 TLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGGGAIVSFEVkGGREAA 319

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1308823969 322 MAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQALDG 392
Cdd:PRK08133  320 WRVIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVAVGLEDVADIKADLARGLAA 390
 
Name Accession Description Interval E-value
PRK08133 PRK08133
O-succinylhomoserine sulfhydrylase; Validated
 3-392 0e+00

O-succinylhomoserine sulfhydrylase; Validated


Pssm-ID: 181244 [Multi-domain]  Cd Length: 390  Bit Score: 540.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   3 DERRYHPKTLAVRAGSEATGYREHSEALFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAM 82
Cdd:PRK08133    1 DDDSLGFDTLAVRAGQLRSPFGEHSEALFLTSSFVFESAAEAAARFAGEEPGNIYSRFTNPTVTMFQERLAALEGAEACV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  83 GVASGMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTL 162
Cdd:PRK08133   81 ATASGMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 163 EVVDLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVrGPILSLCRTTGP 242
Cdd:PRK08133  161 ELADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKELM-EEVFGFLRTAGP 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 243 TLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDV-GSRARA 321
Cdd:PRK08133  240 TLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGGGAIVSFEVkGGREAA 319

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1308823969 322 MAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQALDG 392
Cdd:PRK08133  320 WRVIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVAVGLEDVADIKADLARGLAA 390
MetC COG0626
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ...
 7-391 0e+00

Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440391 [Multi-domain]  Cd Length: 389  Bit Score: 508.82  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   7 YHPKTLAVRAGSE-ATGYREHSEALFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVA 85
Cdd:COG0626     1 MGPATRAVHAGRDpDPQTGAVSPPIYLTSTFVFPSAEALAARFAGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  86 SGMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVV 165
Cdd:COG0626    81 SGMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEVV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 166 DLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRGPILSLCRTTGPTLS 245
Cdd:COG0626   161 DIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALGAVLS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 246 AFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDV-GSRARAMAV 324
Cdd:COG0626   241 PFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFELkGGREAARRF 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1308823969 325 LDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQALD 391
Cdd:COG0626   321 LDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALA 387
O_suc_HS_sulf TIGR01325
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ...
 11-390 9.19e-176

O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 188131  Cd Length: 381  Bit Score: 494.75  E-value: 9.19e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  11 TLAVRAGSEATGYREHSEALFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMSA 90
Cdd:TIGR01325   2 TLAVRGGMLRSGFEETAEALYLTSGYVYDSAAVAAKRFAGELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGMAA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  91 IFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDLSAL 170
Cdd:TIGR01325  82 IFAALMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVDIAAV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 171 AEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRGPILSLCRTTGPTLSAFNAW 250
Cdd:TIGR01325 162 AELAHAAGAKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAILGSEEYMDEPVQKLLRHTGPAMSPFNAW 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 251 VLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDVGSRARAMAVLDRLAL 330
Cdd:TIGR01325 242 VLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGLPSHPQHELAKRQMSGGGTVVTFDLDCRQAAFKVLDAMRL 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 331 FSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQAL 390
Cdd:TIGR01325 322 VDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIGDGLVRLSVGLEDVDDLIADIDRAL 381
CGS_like cd00614
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...
 30-391 1.63e-145

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.


Pssm-ID: 99738 [Multi-domain]  Cd Length: 369  Bit Score: 417.37  E-value: 1.63e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  30 LFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMSAIFTTLLALLDQGDRVVCAR 109
Cdd:cd00614     7 IYQTSTFVFPSPAEAADLFALREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGDHVVASD 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 110 EVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDLSALAEIVHAAGALMVVDNAFCT 189
Cdd:cd00614    87 DLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVVDNTFAT 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 190 PALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRGPILSLCRTTGPTLSAFNAWVLLKSLETLPVRMAAHCDH 269
Cdd:cd00614   167 PYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRMERHSEN 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 270 AEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDV-GSRARAMAVLDRLALFSRTANLGDTRSIVTHPA 348
Cdd:cd00614   247 ALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFELkGGLEAAKKFLNALKLFSLAVSLGGVESLVEHPA 326

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1308823969 349 STTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQALD 391
Cdd:cd00614   327 SMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
Cys_Met_Meta_PP pfam01053
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ...
 11-391 9.68e-142

Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.


Pssm-ID: 395837 [Multi-domain]  Cd Length: 376  Bit Score: 408.16  E-value: 9.68e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  11 TLAVRAGSEA-TGYREHSEALFLTSSFTFDtaaqgariFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMS 89
Cdd:pfam01053   2 TLAVHAGQRPdPQTGAVSVPIYLTSTYVFD--------FAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  90 AIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDLSA 169
Cdd:pfam01053  74 AITAAILALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 170 LAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRGPILSLCRTTGPTLSAFNA 249
Cdd:pfam01053 154 IAKLAKKHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDA 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 250 WVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDVGS-RARAMAVLDRL 328
Cdd:pfam01053 234 WLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGgLEAAKKFLDNL 313

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1308823969 329 ALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQALD 391
Cdd:pfam01053 314 KLFSLAVSLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
 
Name Accession Description Interval E-value
PRK08133 PRK08133
O-succinylhomoserine sulfhydrylase; Validated
 3-392 0e+00

O-succinylhomoserine sulfhydrylase; Validated


Pssm-ID: 181244 [Multi-domain]  Cd Length: 390  Bit Score: 540.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   3 DERRYHPKTLAVRAGSEATGYREHSEALFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAM 82
Cdd:PRK08133    1 DDDSLGFDTLAVRAGQLRSPFGEHSEALFLTSSFVFESAAEAAARFAGEEPGNIYSRFTNPTVTMFQERLAALEGAEACV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  83 GVASGMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTL 162
Cdd:PRK08133   81 ATASGMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 163 EVVDLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVrGPILSLCRTTGP 242
Cdd:PRK08133  161 ELADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKELM-EEVFGFLRTAGP 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 243 TLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDV-GSRARA 321
Cdd:PRK08133  240 TLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGGGAIVSFEVkGGREAA 319

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1308823969 322 MAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQALDG 392
Cdd:PRK08133  320 WRVIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVAVGLEDVADIKADLARGLAA 390
MetC COG0626
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ...
 7-391 0e+00

Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440391 [Multi-domain]  Cd Length: 389  Bit Score: 508.82  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   7 YHPKTLAVRAGSE-ATGYREHSEALFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVA 85
Cdd:COG0626     1 MGPATRAVHAGRDpDPQTGAVSPPIYLTSTFVFPSAEALAARFAGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  86 SGMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVV 165
Cdd:COG0626    81 SGMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEVV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 166 DLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRGPILSLCRTTGPTLS 245
Cdd:COG0626   161 DIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALGAVLS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 246 AFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDV-GSRARAMAV 324
Cdd:COG0626   241 PFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFELkGGREAARRF 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1308823969 325 LDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQALD 391
Cdd:COG0626   321 LDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALA 387
O_suc_HS_sulf TIGR01325
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ...
 11-390 9.19e-176

O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 188131  Cd Length: 381  Bit Score: 494.75  E-value: 9.19e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  11 TLAVRAGSEATGYREHSEALFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMSA 90
Cdd:TIGR01325   2 TLAVRGGMLRSGFEETAEALYLTSGYVYDSAAVAAKRFAGELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGMAA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  91 IFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDLSAL 170
Cdd:TIGR01325  82 IFAALMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVDIAAV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 171 AEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRGPILSLCRTTGPTLSAFNAW 250
Cdd:TIGR01325 162 AELAHAAGAKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAILGSEEYMDEPVQKLLRHTGPAMSPFNAW 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 251 VLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDVGSRARAMAVLDRLAL 330
Cdd:TIGR01325 242 VLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGLPSHPQHELAKRQMSGGGTVVTFDLDCRQAAFKVLDAMRL 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 331 FSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQAL 390
Cdd:TIGR01325 322 VDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIGDGLVRLSVGLEDVDDLIADIDRAL 381
PRK07810 PRK07810
O-succinylhomoserine sulfhydrylase; Provisional
 8-390 1.16e-152

O-succinylhomoserine sulfhydrylase; Provisional


Pssm-ID: 236103 [Multi-domain]  Cd Length: 403  Bit Score: 436.86  E-value: 1.16e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   8 HPKTLAVRAGSEATGYREHSEALFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASG 87
Cdd:PRK07810   15 SQATIGVRGGLLRSGFEETAEALYLTSGYVYESAAAAEAAFTGELDRFVYSRYGNPTVSMFEERLRLIEGAEACFATASG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  88 MSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDL 167
Cdd:PRK07810   95 MSAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQSLVDI 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 168 SALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRGPILSLCRTTGPTLSAF 247
Cdd:PRK07810  175 AAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPALSAF 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 248 NAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMD-----VGSRARAM 322
Cdd:PRK07810  255 NAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYPFLPSHPQYDLAKRQMSGGGTVVTFEldapeDAAKKRAF 334

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1308823969 323 AVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQAL 390
Cdd:PRK07810  335 EVLDKLRVIDISNNLGDAKSLITHPATTTHRAMGPEGRAAIGLGDGVVRLSVGLEDTDDLIADLDRAL 402
MET17 COG2873
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ...
 1-391 3.00e-147

O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 442120 [Multi-domain]  Cd Length: 428  Bit Score: 424.06  E-value: 3.00e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   1 MSdERRYHPKTLAVRAGSE---ATGYRehseAL--FLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAAL 75
Cdd:COG2873     1 MT-EKKYGFETLALHAGQEpdpTTGAR----AVpiYQTTSYVFDDAEHAADLFALKEPGNIYTRIMNPTTDVLEKRIAAL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  76 EGAEAAMGVASGMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVE 155
Cdd:COG2873    76 EGGVAALATASGQAAITLAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 156 TPSNPTLEVVDLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVI--AGS-------- 225
Cdd:COG2873   156 TIGNPALDVLDIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIvdGGNfdwaangk 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 226 -----------------EALvrGPI-------LSLCRTTGPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRG 281
Cdd:COG2873   236 fpeltepdpsyhglvytEAF--GNAafitkarVQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHP 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 282 DLEAVTYPGLPSYRHRDIVQKQMSR-AGALVTMDV-GSRARAMAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEA 359
Cdd:COG2873   314 KVAWVNYPGLPSHPYHELAQKYLPKgAGGVLTFGLkGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEE 393

                         410       420       430
                  ....*....|....*....|....*....|..
gi 1308823969 360 RLAAGVSEGLVRLAIGLEDPRDLVADLAQALD 391
Cdd:COG2873   394 QAAAGVTPDLIRLSVGIEDIDDIIADLDQALA 425
CGS_like cd00614
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...
 30-391 1.63e-145

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.


Pssm-ID: 99738 [Multi-domain]  Cd Length: 369  Bit Score: 417.37  E-value: 1.63e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  30 LFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMSAIFTTLLALLDQGDRVVCAR 109
Cdd:cd00614     7 IYQTSTFVFPSPAEAADLFALREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGDHVVASD 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 110 EVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDLSALAEIVHAAGALMVVDNAFCT 189
Cdd:cd00614    87 DLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVVDNTFAT 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 190 PALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRGPILSLCRTTGPTLSAFNAWVLLKSLETLPVRMAAHCDH 269
Cdd:cd00614   167 PYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRMERHSEN 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 270 AEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDV-GSRARAMAVLDRLALFSRTANLGDTRSIVTHPA 348
Cdd:cd00614   247 ALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFELkGGLEAAKKFLNALKLFSLAVSLGGVESLVEHPA 326

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1308823969 349 STTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQALD 391
Cdd:cd00614   327 SMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
Cys_Met_Meta_PP pfam01053
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ...
 11-391 9.68e-142

Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.


Pssm-ID: 395837 [Multi-domain]  Cd Length: 376  Bit Score: 408.16  E-value: 9.68e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  11 TLAVRAGSEA-TGYREHSEALFLTSSFTFDtaaqgariFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMS 89
Cdd:pfam01053   2 TLAVHAGQRPdPQTGAVSVPIYLTSTYVFD--------FAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  90 AIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDLSA 169
Cdd:pfam01053  74 AITAAILALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 170 LAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRGPILSLCRTTGPTLSAFNA 249
Cdd:pfam01053 154 IAKLAKKHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDA 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 250 WVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDVGS-RARAMAVLDRL 328
Cdd:pfam01053 234 WLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGgLEAAKKFLDNL 313

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1308823969 329 ALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQALD 391
Cdd:pfam01053 314 KLFSLAVSLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
PRK07504 PRK07504
O-succinylhomoserine sulfhydrylase; Reviewed
 2-391 1.01e-141

O-succinylhomoserine sulfhydrylase; Reviewed


Pssm-ID: 168979 [Multi-domain]  Cd Length: 398  Bit Score: 408.76  E-value: 1.01e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   2 SDERRYHPKTLAVRAGSEATGYREHSEALFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAA 81
Cdd:PRK07504    4 EMARKWRPATRLVHSGTLRSQFGETSEALFLTQGFVYDTAEAAEARFKGEDPGFIYSRYSNPTVDMFEKRMCALEGAEDA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  82 MGVASGMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPT 161
Cdd:PRK07504   84 RATASGMAAVTAAILCQVKAGDHVVAARALFGSCRYVVETLLPRYGIESTLVDGLDLDNWEKAVRPNTKVFFLESPTNPT 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 162 LEVVDLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRGPILSLCRTTG 241
Cdd:PRK07504  164 LEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDKAWIEEHLQDYFRHTG 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 242 PTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDV-GSRAR 320
Cdd:PRK07504  244 PSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARVIYPGRADHPQADIIAKQMTGGSTLVAFELkGGKEA 323

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1308823969 321 AMAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQALD 391
Cdd:PRK07504  324 AFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPEARAELGISEGFLRLSAGLEDTDDLIEDLAAALK 394
OAH_OAS_sulfhy TIGR01326
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ...
 8-390 3.28e-119

OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]


Pssm-ID: 273555 [Multi-domain]  Cd Length: 418  Bit Score: 352.05  E-value: 3.28e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   8 HPKTLAVRAGSE---ATGYRehSEALFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGV 84
Cdd:TIGR01326   1 HFETLQLHAGQEpdpTTGSR--AVPIYQTTSYVFDSTEHAAALFGLQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  85 ASGMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEV 164
Cdd:TIGR01326  79 ASGQAAITYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 165 VDLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGS------------------- 225
Cdd:TIGR01326 159 LDIEAIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVDGgkfdwnngrfplfttpdps 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 226 -------EALvrGPI-------LSLCRTTGPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGL 291
Cdd:TIGR01326 239 yhglvftETL--GNPafilkarVQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGL 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 292 PSYRHRDIVQKQMSR-AGALVTMDV-GSRARAMAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGL 369
Cdd:TIGR01326 317 ASHPHHALAKKYLPKgFGAVLSFEIkGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGL 396

                         410       420
                  ....*....|....*....|.
gi 1308823969 370 VRLAIGLEDPRDLVADLAQAL 390
Cdd:TIGR01326 397 IRLSVGIENIDDIIADLEQAL 417
PRK06234 PRK06234
methionine gamma-lyase; Provisional
 11-391 1.07e-116

methionine gamma-lyase; Provisional


Pssm-ID: 168478 [Multi-domain]  Cd Length: 400  Bit Score: 345.27  E-value: 1.07e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  11 TLAVRAGS-EATGYREHSEALFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMS 89
Cdd:PRK06234   11 TKAIHGGHiGDKQFGSLATPIYQTSTFIFDSAEQGGRRFAGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAASGMG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  90 AIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDLSA 169
Cdd:PRK06234   91 AISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANPTLKVTDIKA 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 170 LAEIVHAA--GALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEAL---VRGpiLSLCRTTGPTL 244
Cdd:PRK06234  171 ISNIAHENnkECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVVGKEEFinqVKL--FGIKDMTGSVI 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 245 SAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDV-GSRARAMA 323
Cdd:PRK06234  249 GPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLPGAMISFELkGGVEEGKV 328

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1308823969 324 VLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQALD 391
Cdd:PRK06234  329 VMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQALD 396
met_gam_lyase TIGR01328
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ...
 6-391 4.23e-113

methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]


Pssm-ID: 130395 [Multi-domain]  Cd Length: 391  Bit Score: 335.70  E-value: 4.23e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   6 RYHPKTLAVRAGSEAtgyREHSEAL----FLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAA 81
Cdd:TIGR01328   1 RMTFATRAIHAGYPP---KDQFGALtppiYQTSTFVFDSCEQGGNRFAGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  82 MGVASGMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPT 161
Cdd:TIGR01328  78 VATSSGMGAIAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 162 LEVVDLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAG-SEALVRGPILSLCRTT 240
Cdd:TIGR01328 158 MKLIDMERVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLICGkAELLQQIRMVGIKDMT 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 241 GPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDV-GSRA 319
Cdd:TIGR01328 238 GSVISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPGHDIAAKQMRMGGGMITFELkGGFA 317

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1308823969 320 RAMAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQALD 391
Cdd:TIGR01328 318 GAKKLLNNLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAAGITDGMIRLSVGLEDADDLIADLKQALD 389
PRK07503 PRK07503
methionine gamma-lyase; Provisional
 30-391 6.52e-111

methionine gamma-lyase; Provisional


Pssm-ID: 181005 [Multi-domain]  Cd Length: 403  Bit Score: 330.61  E-value: 6.52e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  30 LFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMSAIFTTLLALLDQGDRVVCAR 109
Cdd:PRK07503   32 VYLTATFAFPTAEYGAECFAGEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALASGMGAITATLWTLLRPGDEVIVDQ 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 110 EVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDLSALAEIVHAAGALMVVDNAFCT 189
Cdd:PRK07503  112 TLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPANPNMRLVDIAAVAEIAHGAGAKVVVDNTYCT 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 190 PALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALV-RGPILSLCRTTGPTLSAFNAWVLLKSLETLPVRMAAHCD 268
Cdd:PRK07503  192 PYLQRPLELGADLVVHSATKYLGGHGDITAGLVVGGKALAdRIRLEGLKDMTGAVMSPFDAFLLMRGLKTLALRMDRHCA 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 269 HAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDV-GSRARAMAVLDRLALFSRTANLGDTRSIVTHP 347
Cdd:PRK07503  272 SAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALPGGMIAFELkGGIAAGRRFMNALQLFARAVSLGDAESLAQHP 351

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1308823969 348 ASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQALD 391
Cdd:PRK07503  352 ASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALD 395
PRK06767 PRK06767
methionine gamma-lyase; Provisional
 5-391 6.00e-110

methionine gamma-lyase; Provisional


Pssm-ID: 180685 [Multi-domain]  Cd Length: 386  Bit Score: 327.57  E-value: 6.00e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   5 RRYHPKTLAVRAGSEATgyrEHSEAL----FLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEA 80
Cdd:PRK06767    2 KKKHMETALIHHGYTSE---EHKGSLtpplFQTSTFTFETAQQGEASFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  81 AMGVASGMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNP 160
Cdd:PRK06767   79 ALAFGSGMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 161 TLEVVDLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRGPILSLCRTT 240
Cdd:PRK06767  159 TMKLIDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDI 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 241 GPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPglpsyrHRDIVQKQMSRAGALVTMDV-GSRA 319
Cdd:PRK06767  239 GGIMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYP------EGELASRQMKRGGGVISFSIkGGKE 312

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1308823969 320 RAMAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQALD 391
Cdd:PRK06767  313 ETQAFINDLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALK 384
PRK08134 PRK08134
O-acetylhomoserine aminocarboxypropyltransferase; Validated
 11-390 5.74e-106

O-acetylhomoserine aminocarboxypropyltransferase; Validated


Pssm-ID: 236159  Cd Length: 433  Bit Score: 318.99  E-value: 5.74e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  11 TLAVRAGSE---ATGYRehSEALFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASG 87
Cdd:PRK08134   11 TLALHAGAApdpATGAR--AVPIHLTTSFVFRDSDHAAALFNLERAGHVYSRISNPTVAVLEERVAALEGGVGAIATASG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  88 MSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDL 167
Cdd:PRK08134   89 QAALHLAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGLEVLDI 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 168 SALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVI---------------------AG-- 224
Cdd:PRK08134  169 PTVAAIAHEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLvdggrfdweasgkfpeltepyAGfh 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 225 ----SEALVRGPILSLCRTT-----GPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYR 295
Cdd:PRK08134  249 gmvfAEESTVAAFLLRARREglrdfGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPELESHP 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 296 HRDIVQKQMSR-AGALVTMDV-GSRARAMAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLA 373
Cdd:PRK08134  329 DHALAKRLLPRgAGSVFSFDLkGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIGEGTIRLS 408

                         410
                  ....*....|....*..
gi 1308823969 374 IGLEDPRDLVADLAQAL 390
Cdd:PRK08134  409 IGLEDADDLIDDLKRAL 425
PRK08248 PRK08248
homocysteine synthase;
1-390 1.51e-99

homocysteine synthase;


Pssm-ID: 236201 [Multi-domain]  Cd Length: 431  Bit Score: 302.53  E-value: 1.51e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   1 MSDERRYHPKTLAVRAGSE---ATGYRehSEALFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEG 77
Cdd:PRK08248    1 MSEERTFRLETLAIHAGQEidpTTGSR--AVPIYQTTSYGFRDSEHAANLFSLKEFGNIYTRIMNPTTDVFEKRIAALEG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  78 AEAAMGVASGMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETP 157
Cdd:PRK08248   79 GIGALAVSSGQAAITYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 158 SNPTLEVVDLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGS------------ 225
Cdd:PRK08248  159 GNPKGDVLDIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVDSgkfdwkgsgkfp 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 226 ---------------EALvrGPI-------LSLCRTTGPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDL 283
Cdd:PRK08248  239 gltepdpsyhglvytDAV--GEAayitkarVQLLRDLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAV 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 284 EAVTYPGLPSYRHRDIVQKQMSRA-GALVTMDV-GSRARAMAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARL 361
Cdd:PRK08248  317 EWVSYPGLPSHPSYELAKKYLPKGqGAILTFGIkGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQL 396

                         410       420
                  ....*....|....*....|....*....
gi 1308823969 362 AAGVSEGLVRLAIGLEDPRDLVADLAQAL 390
Cdd:PRK08248  397 AAGVTPGLVRLSVGTEAIDDILDDLRQAI 425
PRK08249 PRK08249
cystathionine gamma-synthase family protein;
1-392 4.50e-98

cystathionine gamma-synthase family protein;


Pssm-ID: 236202 [Multi-domain]  Cd Length: 398  Bit Score: 297.42  E-value: 4.50e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   1 MSDERRYHPKTLAVRAG-SEATGYREHSEALFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAE 79
Cdd:PRK08249    1 KMDFNNAGVGTKAVWAGeKEYLPYGATQVPVVLSVAYGYDDIDEWYDVALGKKPGHIYSRNTNPTVQAFEEKVRILEGAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  80 AAMGVASGMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSN 159
Cdd:PRK08249   81 AATAFSTGMAAISNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 160 PTLEVVDLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRgPILSLCRT 239
Cdd:PRK08249  161 PTLKIVDIERLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVVCGSKELME-QVYHYREI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 240 TGPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDV-GSR 318
Cdd:PRK08249  240 NGATMDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQMRGFGGILSFVLkGGM 319

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1308823969 319 ARAMAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQALDG 392
Cdd:PRK08249  320 DTVKRLLPKLRYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEGLVRISVGIEDTEDLIADLEQAFAH 393
PRK07812 PRK07812
O-acetylhomoserine aminocarboxypropyltransferase; Validated
 11-390 1.27e-97

O-acetylhomoserine aminocarboxypropyltransferase; Validated


Pssm-ID: 236105  Cd Length: 436  Bit Score: 297.82  E-value: 1.27e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  11 TLAVRAGSE---ATGYRehSEALFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASG 87
Cdd:PRK07812   16 TKQIHAGQTpdpATNAR--ALPIYQTTSYTFDDTDHAAALFGLAEPGNIYTRIMNPTQDVVEQRIAALEGGVAALLLASG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  88 MSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFV--PlGDLDAWRDALKTPTKLVLVETPSNPTLEVV 165
Cdd:PRK07812   94 QAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVedP-DDLDAWRAAVRPNTKAFFAETISNPQIDVL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 166 DLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIA---------------------- 223
Cdd:PRK07812  173 DIPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVdggtfdwtqgrfpgfttpdpsy 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 224 --------GSEALVRGPILSLCRTTGPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYR 295
Cdd:PRK07812  253 hgvvfaelGPPAYALKARVQLLRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLPSSP 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 296 HRDIVQKQMSR-AGALVTMDV-GSRARAMAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLA 373
Cdd:PRK07812  333 WYERAKRLAPKgTGAVLSFELaGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPGLVRLA 412

                         410
                  ....*....|....*..
gi 1308823969 374 IGLEDPRDLVADLAQAL 390
Cdd:PRK07812  413 VGIEGIDDILADLEAGF 429
PRK07811 PRK07811
cystathionine gamma-synthase; Provisional
 1-391 1.11e-95

cystathionine gamma-synthase; Provisional


Pssm-ID: 236104 [Multi-domain]  Cd Length: 388  Bit Score: 291.16  E-value: 1.11e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   1 MSDERRYH-PKTLAVRAGSE---ATGyrEHSEALFLTSSFTFDtAAQGARifakeeAGYLYARFTNPTVTMFEDRYAALE 76
Cdd:PRK07811    4 MSDHHANQgFATRAIHAGYEpdpATG--AVNPPIYASSTFAQD-GVGGLR------GGYEYARTGNPTRTALEEQLAALE 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  77 GAEAAMGVASGMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVET 156
Cdd:PRK07811   75 GGAYGRAFSSGMAATDCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVET 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 157 PSNPTLEVVDLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRGPILSL 236
Cdd:PRK07811  155 PTNPLLSITDIAALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFAFL 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 237 CRTTGPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDV- 315
Cdd:PRK07811  235 QNGAGAVPGPFDAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVRLa 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 316 GSRARAMAVLDRLALFSRTANLGDTRSIVTHPASTTHSRmtpearlAAG----VSEGLVRLAIGLEDPRDLVADLAQALD 391
Cdd:PRK07811  315 GGEEAARDFCARTKVFTLAESLGGVESLIEHPSAMTHAS-------TAGsqleVPDDLVRLSVGIEDVADLLADLEQALG 387
PRK05994 PRK05994
O-acetylhomoserine aminocarboxypropyltransferase; Validated
 11-390 7.59e-95

O-acetylhomoserine aminocarboxypropyltransferase; Validated


Pssm-ID: 180344 [Multi-domain]  Cd Length: 427  Bit Score: 290.08  E-value: 7.59e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  11 TLAVRAGSE---ATGYRehSEALFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASG 87
Cdd:PRK05994   10 TLAVHAGAQpdpTTGAR--ATPIYQTTSFVFNDADHAASLFGLQAFGNIYTRITNPTNAVLEERVAALEGGTAALAVASG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  88 MSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDL 167
Cdd:PRK05994   88 HAAQFLVFHTLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGGTVTDI 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 168 SALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVI--AGS---EALVRGPILS------- 235
Cdd:PRK05994  168 AAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIvdGGTfdwSKSGKYPMLSeprpeyh 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 236 ---------------LCRTT-----GPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYR 295
Cdd:PRK05994  248 glvlhetfgnfafaiAARVLglrdlGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLPDDP 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 296 HRDIVQKQMSR-AGALVTMDV-GSRARAMAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLA 373
Cdd:PRK05994  328 YHALAQKYSPKgAGAVFTFGLkGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDVVRLS 407

                         410
                  ....*....|....*..
gi 1308823969 374 IGLEDPRDLVADLAQAL 390
Cdd:PRK05994  408 IGIEDVDDIIADLEQAL 424
PRK07049 PRK07049
cystathionine gamma-synthase family protein;
5-391 7.06e-87

cystathionine gamma-synthase family protein;


Pssm-ID: 180809 [Multi-domain]  Cd Length: 427  Bit Score: 269.62  E-value: 7.06e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   5 RRYHPKTLAVRAGSEAtgyrEHSEA-----LFLTSSFTFDTAAQGARIF----------AKEEAGYLYARFTNPTVTMFE 69
Cdd:PRK07049   14 RELHPETQMLNYGYDP----ELSEGavkppVFLTSTFVFRSAEDGRDFFdyvsgrkeppAGEGAGLVYSRFNHPNSEIVE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  70 DRYAALEGAEAAMGVASGMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLG-DLDAWRDAL--- 145
Cdd:PRK07049   90 DRLAVYEGAESAALFSSGMSAIATTLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGAVGFADGlSEAAIGAAAeaa 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 146 --KTPTKLVLVETPSNPTLEVVDLSALAEIVHAAGA------LMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRV 217
Cdd:PRK07049  170 aaKGRVSLILIETPANPTNSLVDVAAVRRVADAIEArqghrpIIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDL 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 218 LGGVIAGSEALVRgPILSLCRTTGPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGL--PSYR 295
Cdd:PRK07049  250 VAGAVLGRKALIR-QVRALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLPFldPDSA 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 296 HRDIVQKQMSRAGALVTMDV-GSRARAMAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAI 374
Cdd:PRK07049  329 YGAVYKRQCTGAGSTFSFDIkGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVLESTIRLSI 408

                         410
                  ....*....|....*..
gi 1308823969 375 GLEDPRDLVADLAQALD 391
Cdd:PRK07049  409 GIEHPDDLIADLAQALD 425
PRK07671 PRK07671
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
49-391 3.91e-85

bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;


Pssm-ID: 181076 [Multi-domain]  Cd Length: 377  Bit Score: 263.51  E-value: 3.91e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  49 AKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMSAIfTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGI 128
Cdd:PRK07671   36 VGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAI-TAVMMLFSSGDHVILTDDVYGGTYRVMTKVLNRFGI 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 129 RPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSAT 208
Cdd:PRK07671  115 EHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTIAKEKGLLTIVDNTFMTPYWQSPISLGADIVLHSAT 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 209 KFIDGQGRVLGGVIAGSEALVRGPILSLCRTTGPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTY 288
Cdd:PRK07671  195 KYLGGHSDVVAGLVVVNSPELAEDLHFVQNSTGGILGPQDSWLLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYY 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 289 PGLPSYRHRDIVQKQMSRAGALVTMDVGSRARAMAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEG 368
Cdd:PRK07671  275 PGLPSHPNHELAKEQANGFGGMISFDVGSEETANKVLERLQYFTLAESLGAVESLISIPSQMTHASIPADRRKELGITDG 354

                         330       340
                  ....*....|....*....|...
gi 1308823969 369 LVRLAIGLEDPRDLVADLAQALD 391
Cdd:PRK07671  355 LIRISVGIEDGEDLIEDLAQALA 377
PRK08064 PRK08064
cystathionine beta-lyase MetC;
55-391 1.65e-83

cystathionine beta-lyase MetC;


Pssm-ID: 236146 [Multi-domain]  Cd Length: 390  Bit Score: 260.09  E-value: 1.65e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  55 YLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMSAIFTTLLaLLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVP 134
Cdd:PRK08064   46 YDYSRSGNPTREALEDIIAELEGGTKGFAFASGMAAISTAFL-LLSKGDHVLISEDVYGGTYRMITEVLSRFGIEHTFVD 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 135 LGDLDAWRDALKTPTKLVLVETPSNPTLEVVDLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQ 214
Cdd:PRK08064  125 MTNLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRGVVKLAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGH 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 215 GRVLGGVIAGSEALVRGPILSLCRTTGPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSY 294
Cdd:PRK08064  205 SDVLAGLAVVKDEELAQKLYFLQNSFGAVLGVQDCWLVLRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQTH 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 295 RHRDIVQKQMSRAGALVTMDVGSRARAMAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAI 374
Cdd:PRK08064  285 LGFDIQQSQATSAGAVLSFTLQSEEAVRQFVSHVKLPVFAVSLGAVESILSYPAKMSHAAMPKEERDERGITDGLLRLSV 364

                         330
                  ....*....|....*..
gi 1308823969 375 GLEDPRDLVADLAQALD 391
Cdd:PRK08064  365 GLENVDDLIADFEQALS 381
PRK06084 PRK06084
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
9-391 6.17e-83

bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;


Pssm-ID: 180392 [Multi-domain]  Cd Length: 425  Bit Score: 259.45  E-value: 6.17e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   9 PKTLAVRAG-SEATGYREHSEALFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASG 87
Cdd:PRK06084    3 LETLAIHAGySPDPTTKAVAVPIYQTTSYAFDDTQHGADLFDLKVPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVASG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  88 MSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDL 167
Cdd:PRK06084   83 MAAITYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIIDI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 168 SALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGS---------------------- 225
Cdd:PRK06084  163 QALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSgkfpwaehkerfallntpdpsy 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 226 ------EALVRGPILSLC-----RTTGPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSY 294
Cdd:PRK06084  243 hgvtytEAFGPAAFIGRCrvvplRNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPDH 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 295 RHRDIVQKQMS-RAGALVTMDV-GSRARAMAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRL 372
Cdd:PRK06084  323 PEHELARRYMGgKPASILSFGIkGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDMVRL 402

                         410
                  ....*....|....*....
gi 1308823969 373 AIGLEDPRDLVADLAQALD 391
Cdd:PRK06084  403 SIGIEHIDDIIADLAQALD 421
PRK08776 PRK08776
O-succinylhomoserine (thiol)-lyase;
8-390 2.48e-80

O-succinylhomoserine (thiol)-lyase;


Pssm-ID: 181554 [Multi-domain]  Cd Length: 405  Bit Score: 252.22  E-value: 2.48e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   8 HPKTLAVRAGSEA-TGYREHSEALFLTSSFTFDTAAQGARifakeeagYLYARFTNPTVTMFEDRYAALEGAEAAMGVAS 86
Cdd:PRK08776   12 SAATAAVRAGIDRdTAYGAVTPPIVLSSNFSFDGFGNKRQ--------YDYTRSGNPTRDLLGEALAELEGGAGGVITAT 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  87 GMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVD 166
Cdd:PRK08776   84 GMGAINLVLNALLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITADLTDPRSLADALAQSPKLVLIETPSNPLLRITD 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 167 LSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRGPILSLCRTTGPTLSA 246
Cdd:PRK08776  164 LRFVIEAAHKVGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELHQQLVWWANALGLTGSP 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 247 FNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDV-GSRARAMAVL 325
Cdd:PRK08776  244 FDAFLTLRGLRTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPGHALAARQQKGFGAMLSFELeGGEAAVRAFV 323

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1308823969 326 DRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQAL 390
Cdd:PRK08776  324 DGLRYFTLAESLGGVESLIAHPASMTHAAMTAEARAAAGISDGLLRLSVGIESAEDLLIDLRAGL 388
PRK05613 PRK05613
O-acetylhomoserine/O-acetylserine sulfhydrylase;
30-391 5.80e-80

O-acetylhomoserine/O-acetylserine sulfhydrylase;


Pssm-ID: 168128 [Multi-domain]  Cd Length: 437  Bit Score: 252.48  E-value: 5.80e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  30 LFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMSAIFTTLLALLDQGDRVVCAR 109
Cdd:PRK05613   36 IYQTTSYVFDSAEHAKQRFALEDLGPIYSRLTNPTVEALENRIASLEGGVHAVAFASGQAAETAAILNLAGAGDHIVTSP 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 110 EVFGSTYLLVEQILPRWGIRPTFVP-LGDLDAWRDALKTPTKLVLVETPSNPTLEVVDLSALAEIVHAAGALMVVDNAFC 188
Cdd:PRK05613  116 RLYGGTETLFLVTLNRLGIEVTFVEnPDDPESWQAAVQPNTKAFFGETFANPQADVLDIPAVAEVAHRNQVPLIVDNTIA 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 189 TPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIA-----------------------------------GSEALVRGPI 233
Cdd:PRK05613  196 TAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIdggkfdwtverdgkpvfpyfvtpdpayhglkyadlGAPAFGLKAR 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 234 LSLCRTTGPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQK-QMSRAGALVT 312
Cdd:PRK05613  276 AGLLRDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFAGLKDSPWYATKEKlGLKYTGSVLS 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 313 MDV-GSRARAMAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQALD 391
Cdd:PRK05613  356 FDIkGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAGITQATVRLSVGIEDIDDIIADLEGGFA 435
PRK08574 PRK08574
cystathionine gamma-synthase family protein;
11-392 8.48e-79

cystathionine gamma-synthase family protein;


Pssm-ID: 236298 [Multi-domain]  Cd Length: 385  Bit Score: 247.67  E-value: 8.48e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  11 TLAVRAGSEATGYREHSEALFLTSSFTFDTAAQgarifaKEEAG--YLYARFTNPTVTMFEDRYAALEGAEAAMGVASGM 88
Cdd:PRK08574    5 TDAVRGYRGSDPYGSLQPPIYLTALFRQEGEAY------PSDRGfdLKYSREENPTLRPLEEALAKLEGGVDALAFNSGM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  89 SAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQiLPRWGIRPTFV-PlgDLDAWRDALK-TPTKLVLVETPSNPTLEVVD 166
Cdd:PRK08574   79 AAISTLFFSLLKAGDRVVLPMEAYGTTLRLLKS-LEKFGVKVVLAyP--STEDIIEAIKeGRTKLVFIETMTNPTLKVID 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 167 LSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRGPILSLCRTTGPTLSA 246
Cdd:PRK08574  156 VPEVAKAAKELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEELWEWRRRLGTIMQP 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 247 FNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRA--GALVTMDV-GSRARAMA 323
Cdd:PRK08574  236 FEAYLVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRLFGKDlyGGVVSFRVkGGRDAVLK 315

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1308823969 324 VLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQALDG 392
Cdd:PRK08574  316 FLRSLKLIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQALGS 384
PRK07582 PRK07582
cystathionine gamma-lyase; Validated
 51-392 1.10e-75

cystathionine gamma-lyase; Validated


Pssm-ID: 236061  Cd Length: 366  Bit Score: 239.13  E-value: 1.10e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  51 EEAGYLYARFTNPTVTMFEDRYAALEGAEAAMgVASGMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRP 130
Cdd:PRK07582   39 PTGPDTYGRASNPTWRALEAALGELEGAEALV-FPSGMAAITAVLRALLRPGDTVVVPADGYYQVRALAREYLAPLGVTV 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 131 TFVPLGDLdaWRDALkTPTKLVLVETPSNPTLEVVDLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKF 210
Cdd:PRK07582  118 REAPTAGM--AEAAL-AGADLVLAETPSNPGLDVCDLAALAAAAHAAGALLVVDNTTATPLGQRPLELGADLVVASDTKA 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 211 IDGQGRVLGGVIAGSEALVRGPILSLCRTTGPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPG 290
Cdd:PRK07582  195 LTGHSDLLLGYVAGRDPELMAAVERWRLLAGAIPGPFEAWLAHRSLGTLGLRFARQCANALAVAELLAGHPAVRGVRYPG 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 291 LPSYRHRDIVQKQMSRAGALVTMDVGSRARAMAVLDRLALFSRTANLGDTRsivthpasTTHSRmtpEARLAAGVSEGLV 370
Cdd:PRK07582  275 LPGDPAHEVAARQMRRFGGLVSFELADAAAAERFVAASRLVVAATSFGGVH--------TSADR---RARWGDAVPEGFV 343

                         330       340
                  ....*....|....*....|..
gi 1308823969 371 RLAIGLEDPRDLVADLAQALDG 392
Cdd:PRK07582  344 RLSCGIEDTDDLVADLERALDA 365
PRK05968 PRK05968
hypothetical protein; Provisional
 1-392 3.51e-75

hypothetical protein; Provisional


Pssm-ID: 168320 [Multi-domain]  Cd Length: 389  Bit Score: 238.44  E-value: 3.51e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   1 MSDERRYHPKTLAVRAGSEATGYREHSEALFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEA 80
Cdd:PRK05968    1 MNDGLDPFDLAALITAHDEGNAFDAVVPPIFQTSLFTFDSYDEMEDVYAGEKVRPIYSRGDNPTVRAFEEMLAKLEGAED 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  81 AMGVASGMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTpTKLVLVETPSNP 160
Cdd:PRK05968   81 ARGFASGMAAISSTVLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKALPG-AKLLYLESPTSW 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 161 TLEVVDLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALV---RGPILSLc 237
Cdd:PRK05968  160 VFELQDVAALAALAKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAGSKEHIariNAEAYPY- 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 238 rtTGPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLpsyrhRDIVQKQMSRAGALVTMDVGS 317
Cdd:PRK05968  239 --LGAKLSPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPAL-----ANHPPAGLSGTSGLFSFIFRE 311

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1308823969 318 RARAMAVLDRLALFSRTANLGDTRSIVThPASTTHSRMTPEARLAA-GVSEGLVRLAIGLEDPRDLVADLAQALDG 392
Cdd:PRK05968  312 GIDVRAFADALKLFRLGVSWGGHESLVV-PAEVVLQQKAQPNSAARfGVSPRSVRLHVGLEGTEALWADLEQALAA 386
PRK08247 PRK08247
methionine biosynthesis PLP-dependent protein;
51-390 2.83e-74

methionine biosynthesis PLP-dependent protein;


Pssm-ID: 181320 [Multi-domain]  Cd Length: 366  Bit Score: 235.37  E-value: 2.83e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  51 EEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMSAIfTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRP 130
Cdd:PRK08247   40 ESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAI-QLVMSLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRF 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 131 TFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKF 210
Cdd:PRK08247  119 VYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAKIAKKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKY 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 211 IDGQGRVLGG-VIAGSEALVRgPILSLCRTTGPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYP 289
Cdd:PRK08247  199 LGGHNDVLAGlVVAKGQELCE-RLAYYQNAAGAVLSPFDSWLLIRGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYP 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 290 GlpsyrhrdivqkqmsrAGALVTMDVGSRARAMAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGL 369
Cdd:PRK08247  278 G----------------RGGMLSFRLQDEEWVNPFLKSLKLITFAESLGGVESFITYPATQTHADIPEEIRIANGVCNRL 341

                         330       340
                  ....*....|....*....|.
gi 1308823969 370 VRLAIGLEDPRDLVADLAQAL 390
Cdd:PRK08247  342 LRFSVGIENVEDLIADLKQAF 362
cysta_beta_ly_E TIGR01329
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ...
 9-390 1.45e-73

cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.


Pssm-ID: 273557 [Multi-domain]  Cd Length: 378  Bit Score: 233.95  E-value: 1.45e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   9 PKTLAVRAGSEATGYREHSEALFLTSSFTFDTAAQGARifakeeagYLYARFTNPTVTMFEDRYAALEGAEAAMGVASGM 88
Cdd:TIGR01329   1 LSTLLVNTDNKNDPYDASSMPIYQTATFKQPLAIENGP--------YDYTRSGNPTRTALESLLAKLDKADRAFAFSSGM 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  89 SAIfTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDLS 168
Cdd:TIGR01329  73 AAL-DVITRLLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIR 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 169 ALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIA-GSEALVRgPILSLCRTTGPTLSAF 247
Cdd:TIGR01329 152 KISEMAHAQNALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAvKGEEIAK-KVYFLQNSTGSGLAPF 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 248 NAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDVGSRARAMAVLDR 327
Cdd:TIGR01329 231 DCWLLLRGIKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQAKGAGSVLSFETGSVALSKRLVEA 310

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1308823969 328 LALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQAL 390
Cdd:TIGR01329 311 TKLFSITVSFGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAF 373
PRK06460 PRK06460
hypothetical protein; Provisional
 32-390 1.24e-72

hypothetical protein; Provisional


Pssm-ID: 235807 [Multi-domain]  Cd Length: 376  Bit Score: 231.64  E-value: 1.24e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  32 LTSSFTFDTAAQGARIFAKEEAgYLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMSAIFTTLLALLDQGDRVVCAREV 111
Cdd:PRK06460   15 ATGAITTPIYQTTAYHYPEGEK-YRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTALALLKPGNSVLVHRDM 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 112 FGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDLSALAEIVHAAGALMVVDNAFCTPA 191
Cdd:PRK06460   94 FGRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKENGSILIVDATFSTPI 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 192 LQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRgPILSLCRTTGPTLSAFNAWVLLKSLETLPVRMAAHCDHAE 271
Cdd:PRK06460  174 NQKPLELGADIVVHSASKFLAGHNDVIAGLAAGYGKLLN-VIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVINRNAE 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 272 AVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDV-GSRARAMAVLDRLALFSRTANLGDTRSIVTHPAST 350
Cdd:PRK06460  253 QIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKGFGGVLSFEVnGGQESALKVMKSLKLIIPAQTLGGVNSVISHPATM 332

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1308823969 351 THSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQAL 390
Cdd:PRK06460  333 SHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRAL 372
PRK05939 PRK05939
cystathionine gamma-synthase family protein;
33-392 2.48e-72

cystathionine gamma-synthase family protein;


Pssm-ID: 235650 [Multi-domain]  Cd Length: 397  Bit Score: 231.50  E-value: 2.48e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  33 TSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMSAIFTTLLALLDQGDRVVCAREVF 112
Cdd:PRK05939   17 SVTYGYEDARDLIDVFQGKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRAGDHLVSSQFLF 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 113 GSTYLLVeQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDLSALAEIVHAAGALMVVDNAFCTPAL 192
Cdd:PRK05939   97 GNTNSLF-GTLRGLGVEVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYVVDNTMTSPWL 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 193 QRPLAHGADLTVTSATKFIDGQGRVLGGVIAGS------------EALVRGPILSL---------CRTTGPTLSAFNAWV 251
Cdd:PRK05939  176 FRPKDVGASLVINSLSKYIAGHGNALGGAVTDTglfdwsaypnifPAYRKGDPQQWgltqirkkgLRDMGATLSSEAAHR 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 252 LLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDVGSRARAMAVLDRLALF 331
Cdd:PRK05939  256 IAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELFRHYGGLLSFELADGIDCFDFLNRLKLV 335

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1308823969 332 SRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQALDG 392
Cdd:PRK05939  336 IKATHLGDTRTLVIPVAPTIYYEMGAERRASMGIADSLIRVSVGIEDEADLIADFEQALDA 396
PLN02242 PLN02242
methionine gamma-lyase
 33-375 9.18e-72

methionine gamma-lyase


Pssm-ID: 215134  Cd Length: 418  Bit Score: 230.42  E-value: 9.18e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  33 TSSFTFDTAAQGARIFAKE---EAG-YLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMSAIFTTLLALLDQGDRVVCA 108
Cdd:PLN02242   42 SATFTVMEPDTMRRMFSGElgpDRDfYIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLQLCSSGGHVVAS 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 109 REVFGSTYLLVEQILPR-WGIRPTFVPLGDLDAWRDAL-KTPTKLVLVETPSNPTLEVVDLSALAEIVHAAGALMVVDNA 186
Cdd:PLN02242  122 NTLYGGTHALLAHFLPRkCNITTTFVDITDLEAVKKAVvPGKTKVLYFESISNPTLTVADIPELARIAHEKGVTVVVDNT 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 187 FcTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVR-------GPILSLcrttGPTLSAFNAWVLLKSLETL 259
Cdd:PLN02242  202 F-APMVLSPARLGADVVVHSISKFISGGADIIAGAVCGPAELVNsmmdlhhGALMLL----GPTMNPKVAFELSERLPHL 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 260 PVRMAAHCDHAEAVAAALALRGdlEAVTYPGLPSYRHRDIVQKQMSR---AGALVTMDVGSRARAMAVLDRL---ALFSR 333
Cdd:PLN02242  277 SLRMKEHCRRAMEYAKRMKELG--LKVIYPGLEDHPQHALLKSMANKgygFGGLLCLDMDTEERANRLMRYLqnsTQFGF 354

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1308823969 334 TA-NLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIG 375
Cdd:PLN02242  355 MAvSLGYYETLMSCSGSSTSSELDPEEKAAAGISPGLVRMSVG 397
PRK08045 PRK08045
cystathionine gamma-synthase; Provisional
 9-390 9.37e-72

cystathionine gamma-synthase; Provisional


Pssm-ID: 169194 [Multi-domain]  Cd Length: 386  Bit Score: 229.40  E-value: 9.37e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   9 PKTLAVRAG-SEATGYREHSEALFLTSSFTFDTAAQgarifakeEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASG 87
Cdd:PRK08045    5 QATIAVRSGlNDDEQYGCVVPPIHLSSTYNFTGFNE--------PRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  88 MSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDL 167
Cdd:PRK08045   77 MSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 168 SALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRGPILSLCRTTGPTLSAF 247
Cdd:PRK08045  157 AKICHLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAF 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 248 NAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDV-GSRARAMAVLD 326
Cdd:PRK08045  237 DSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELdGDEQTLRRFLG 316

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1308823969 327 RLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQAL 390
Cdd:PRK08045  317 GLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGF 380
PRK08861 PRK08861
O-succinylhomoserine (thiol)-lyase;
1-389 3.05e-71

O-succinylhomoserine (thiol)-lyase;


Pssm-ID: 181567 [Multi-domain]  Cd Length: 388  Bit Score: 228.24  E-value: 3.05e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   1 MSDERryhPKTLAVRAGSEA-TGYREHSEALFLTSSFTFDTAAqgarifakEEAGYLYARFTNPTVTMFEDRYAALEGAE 79
Cdd:PRK08861    1 MSTRK---PATIAVRTGIESdSQYHAVVPPIYLSTNYGFPAFG--------EVPKYDYTRSGNPNRGLLEQTLSELESGK 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  80 AAMGVASGMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSN 159
Cdd:PRK08861   70 GAVVTNCGTSALNLWVSALLGPDDLIVAPHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSN 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 160 PTLEVVDLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRGPILSLCRT 239
Cdd:PRK08861  150 PLVRVVDIAELCQKAKAVGALVAVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNC 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 240 TGPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDVGSRA 319
Cdd:PRK08861  230 IGATGTPFDSYMTLRGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQSGFGSMLSFEFAGSF 309

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1308823969 320 RAMAV-LDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQA 389
Cdd:PRK08861  310 EQLKVfVKALALFSLAESLGGVESLICHPASMTHRAMGEEALAEAGVSQQLLRLSVGLEDAQDLIADLDQA 380
PRK06176 PRK06176
cystathionine gamma-synthase;
54-390 1.39e-69

cystathionine gamma-synthase;


Pssm-ID: 180443 [Multi-domain]  Cd Length: 380  Bit Score: 223.62  E-value: 1.39e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  54 GYLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMSAIFTtLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFV 133
Cdd:PRK06176   41 GYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA-VFSLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTII 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 134 PLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDG 213
Cdd:PRK06176  120 DTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGG 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 214 QGRVLGGVIAGSEALVRGPILSLCRTTGPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPS 293
Cdd:PRK06176  200 HSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPT 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 294 YRHRDIVQKQMSRAGALVTMDVGSRARAMAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLA 373
Cdd:PRK06176  280 HPNHELAKKQMRGFSGMLSFTLKNDSEAVAFVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLS 359

                         330
                  ....*....|....*..
gi 1308823969 374 IGLEDPRDLVADLAQAL 390
Cdd:PRK06176  360 VGIEHEQDLLEDLEQAF 376
PRK06434 PRK06434
cystathionine gamma-lyase; Validated
 30-391 1.03e-68

cystathionine gamma-lyase; Validated


Pssm-ID: 102374 [Multi-domain]  Cd Length: 384  Bit Score: 221.70  E-value: 1.03e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  30 LFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMSAIFTTLLALLDQGDRVVCAR 109
Cdd:PRK06434   31 IFETSTFVYPNSEKEAYMDSTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSSGMGAITSAILSLIKKGKRILSIS 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 110 EVFGSTYLLVEQILPRWGIRPTFVplgDLDAWRDALKTPTK--LVLVETPSNPTLEVVDLSALAEIVHaaGALMVVDNAF 187
Cdd:PRK06434  111 DLYGQTFYFFNKVLKTLGIHVDYI---DTDRLNSLDFDPSNydLIYAESITNPTLKVPDIKNVSSFCH--ENDVIVDATF 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 188 CTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRGPILSLCRTTGPTLSAFNAWVLLKSLETLPVRMAAHC 267
Cdd:PRK06434  186 ASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNLVERRKTLGSNPDPIQAYLALRGLKTLGLRMEKHN 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 268 DHAEAVAAALALRGDLEAVTYPGLpsyrhrDIVQKQMSRAGALVTMDVGSRARAMAVLDRLALFSRTANLGDTRSIVTHP 347
Cdd:PRK06434  266 KNGMELARFLRDSKKISNVYYPDT------EIGKKVLRGFGGMLSFELRSMEDVHKFIRNLEIPMVAASLGGVESLITLP 339

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1308823969 348 ASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQALD 391
Cdd:PRK06434  340 VETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENALS 383
PLN02509 PLN02509
cystathionine beta-lyase
 11-390 5.56e-64

cystathionine beta-lyase


Pssm-ID: 178125 [Multi-domain]  Cd Length: 464  Bit Score: 211.81  E-value: 5.56e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  11 TLAVRAGSEATGYREHSEALFLTSSFTFDTAAqgarifakEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMSA 90
Cdd:PLN02509   89 TLLVNLDNKFDPFDAMSTPLYQTATFKQPSAI--------ENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAA 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  91 IfTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDLSAL 170
Cdd:PLN02509  161 L-SAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKI 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 171 AEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIA-GSEALVRgPILSLCRTTGPTLSAFNA 249
Cdd:PLN02509  240 AEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAvKGEKLAK-EVYFLQNSEGSGLAPFDC 318

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 250 WVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDVGSRARAMAVLDRLA 329
Cdd:PLN02509  319 WLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTK 398

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1308823969 330 LFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQAL 390
Cdd:PLN02509  399 YFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAF 459
PRK07269 PRK07269
cystathionine gamma-synthase; Reviewed
 7-392 2.51e-59

cystathionine gamma-synthase; Reviewed


Pssm-ID: 235983  Cd Length: 364  Bit Score: 196.58  E-value: 2.51e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   7 YHPKTLAVRAG---SEATGYrehsealfLTSSFTFDTAAQGARiFAKEeAGYLYARFTNPTVTMFEDRYAALEGAEAAMG 83
Cdd:PRK07269    5 LHINTILAQAGiksDEATGA--------LVTPLHFSTTYQHPE-FGQS-TGFDYTRTKNPTRAKLEETLAAIESADYALA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  84 VASGMSAIfTTLLALLDQGDRVVCAREVFGSTYllveqilpRW-------GiRPTFVPLGDLDAWRDALKTPTKLVLVET 156
Cdd:PRK07269   75 TSSGMSAI-VLAFSVFPVGSKVVAVRDLYGGSF--------RWfnqqekeG-RFHFTYANTEEELIAAIEEDTDIVYIET 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 157 PSNPTLEVVDLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRGPILSL 236
Cdd:PRK07269  145 PTNPLMVEFDIEKVAKLAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLELYEKLFYN 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 237 CRTTGPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLpsyrhrdivqkqmsraGALVTMDVG 316
Cdd:PRK07269  225 LNTTGAVLSPFDSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYTGK----------------GGMISFKVA 288

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1308823969 317 SRARAMAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGLEDPRDLVADLAQALDG 392
Cdd:PRK07269  289 DETRIPHILNSLKVFTFAESLGGVESLITYPTTQTHADIPAEVRHSYGLTDDLLRLSIGIEDARDLIADLKQALEG 364
PRK06702 PRK06702
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
11-392 4.57e-58

bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;


Pssm-ID: 102505 [Multi-domain]  Cd Length: 432  Bit Score: 195.27  E-value: 4.57e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  11 TLAVRAGSEATGYREHSEALFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMSA 90
Cdd:PRK06702    9 TICVQGGYTPKNGEPRVLPLYQSTTYKYDTSDDLAALFNLEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASGQAA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  91 IFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFV-PLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDLSA 169
Cdd:PRK06702   89 IMLAVLNICSSGDHLLCSSTVYGGTFNLFGVSLRKLGIDVTFFnPNLTADEIVALANDKTKLVYAESLGNPAMNVLNFKE 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 170 LAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIA-------------------------- 223
Cdd:PRK06702  169 FSDAAKELEVPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIdggnfdwtngkypelvepdpsyhgvs 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 224 -----GSEALVRGPILSLCRTTGPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRD 298
Cdd:PRK06702  249 yvqnfGAAAYIVKARVQLLRDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSNENYS 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 299 IVQKQMSR-AGALVTMDV-GSRARAMAVLDRLALFSRTANLGDTRSIVTHPASTTHSRMTPEARLAAGVSEGLVRLAIGL 376
Cdd:PRK06702  329 LAQKYLKKgASGVLTFGIkGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRLSVGI 408

                         410
                  ....*....|....*.
gi 1308823969 377 EDPRDLVADLAQALDG 392
Cdd:PRK06702  409 EDVSDIIADLEAALVG 424
PRK07050 PRK07050
cystathionine beta-lyase; Provisional
 8-390 5.24e-43

cystathionine beta-lyase; Provisional


Pssm-ID: 180810 [Multi-domain]  Cd Length: 394  Bit Score: 154.50  E-value: 5.24e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969   8 HPKTLAVRAGSEAT-GYREHSEALFLTSSFTFDTAAQGARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVAS 86
Cdd:PRK07050    9 ALQTRIVQPDDQIPpGFRSFVTPVARASTVVFPDLATMRALDWRQDVQWRYGLHATPTSLALAQRLAEIEGGRHALLQPS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  87 GMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVD 166
Cdd:PRK07050   89 GLAAISLVYFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWLEAPGSVTMEVPD 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 167 LSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEALVRGPILSLCRTTGPTLSA 246
Cdd:PRK07050  169 VPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADAELHAKLKLARMRLGIGVSA 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 247 FNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGAL--VTMDVG-SRARAMA 323
Cdd:PRK07050  249 DDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGGLfsVVFDERySPAQVDA 328

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1308823969 324 VLDRLALFSRTANLGDTRSI-VTHPASTTHSRMTPEArlaagvsEGLVRLAIGLEDPRDLVADLAQAL 390
Cdd:PRK07050  329 FVEALELFAIGWSWGGACSLaMPYDVASMRTAKWPHR-------GTLVRLYIGLEDEADLIADLEQAL 389
PRK05967 PRK05967
cystathionine beta-lyase; Provisional
 45-390 3.00e-36

cystathionine beta-lyase; Provisional


Pssm-ID: 235657 [Multi-domain]  Cd Length: 395  Bit Score: 136.48  E-value: 3.00e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  45 ARIFAKEEAGYLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILP 124
Cdd:PRK05967   46 AETMATRGQKYTYGTRGTPTTDALCKAIDALEGSAGTILVPSGLAAVTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLK 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 125 RWGIRPTFV-PLgdLDAWRDALKTP-TKLVLVETPSNPTLEVVDLSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADL 202
Cdd:PRK05967  126 RLGVEVEYYdPE--IGAGIAKLMRPnTKVVHTEAPGSNTFEMQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDI 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 203 TVTSATKFIDGQGRVLGGVIAGSEAlvRGPILSLCRTT-GPTLSAFNAWVLLKSLETLPVRMAAHCDHAEAVAAALALRG 281
Cdd:PRK05967  204 SIHAATKYPSGHSDILLGTVSANEK--CWPQLLEAHGTlGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRP 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 282 DLEAVTYPGLPSYRHRDIVQKQMSRAGALVTM-----DVGSRARAMAVLDRLALFSRTANLGDTRSIVTHPASTthsrmt 356
Cdd:PRK05967  282 DVARVLHPALPSFPGHEIWKRDFSGASGIFSFvlaagPEKGKAKAHAFLDALEIFGLGYSWGGYESLALHVKLG------ 355

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1308823969 357 pEARLAAGVSEG-LVRLAIGLEDPRDLVADLAQAL 390
Cdd:PRK05967  356 -DRTVAKAPYAGpVIRLQIGLEDVPDLKADLERGF 389
PRK09028 PRK09028
cystathionine beta-lyase; Provisional
 30-391 6.34e-30

cystathionine beta-lyase; Provisional


Pssm-ID: 181615 [Multi-domain]  Cd Length: 394  Bit Score: 119.07  E-value: 6.34e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  30 LFLTSSFTFDTAAQgARIFAKEEAG--YLYARFTNPTVTMFEDRYAALEGAEAAMGVASGMSAIFTTLLALLDQGDRVVC 107
Cdd:PRK09028   27 VFRASTVVFDTVAE-MRHAAKNRANgeMFYGRRGTPTHFAFQAAIVELEGGAGTALYPSGAAAISNALLSFLKAGDHLLM 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 108 AREVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRDALKTPTKLVLVETPSNPTLEVVDLSALAEIVHAAGALMVVDNAF 187
Cdd:PRK09028  106 VDSCYEPTRDLCDKILKGFGIETTYYDPMIGEGIRELIRPNTKVLFLESPGSITMEVQDVPTLSRIAHEHDIVVMLDNTW 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 188 CTPALQRPLAHGADLTVTSATKFIDGQGRVLGGVIAGSEA----LVRGPILslcrtTGPTLSAFNAWVLLKSLETLPVRM 263
Cdd:PRK09028  186 ASPINSRPFEMGVDISIQAATKYIVGHSDVMLGTATANEKhwdqLREHSYL-----MGQCTSPDDVYLAMRGLRTLGVRL 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 264 AAHCDHAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVT--MDVGSRARAMAVLDRLALFSRTANLGDTR 341
Cdd:PRK09028  261 AQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSNGLFSfvLKQGDPKAVTALVEGMQHFKMGFSWGGFE 340

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1308823969 342 SIVTHPASTTHSRMTpearlAAGVSEG-LVRLAIGLEDPRDLVADLAQALD 391
Cdd:PRK09028  341 SLILGVFGINKLRTA-----TNWDFSKpLIRLHIGLEDVDDLIADLEAGFE 386
PRK08114 PRK08114
cystathionine beta-lyase; Provisional
 33-387 9.51e-23

cystathionine beta-lyase; Provisional


Pssm-ID: 181231 [Multi-domain]  Cd Length: 395  Bit Score: 98.62  E-value: 9.51e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  33 TSSFTFDTAAQGARIFAKEEAGYL-YARFTNPTVTMFEDRYAALEGAEAAMGVASGMSAIFTTLLALLDQGDRVVCAREV 111
Cdd:PRK08114   31 ASSLVFDSVEAKKHATRNRANGELfYGRRGTLTHFSLQEAMCELEGGAGCALYPCGAAAVANAILAFVEQGDHVLMTGTA 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 112 FGSTYLLVEQILPRWGIRPT-FVPLGDLDAwRDALKTPTKLVLVETPSNPTLEVVDLSALAEIVHAAG--ALMVVDNAFC 188
Cdd:PRK08114  111 YEPTQDFCSKILSKLGVTTTwFDPLIGADI-AKLIQPNTKVVFLESPGSITMEVHDVPAIVAAVRSVNpdAVIMIDNTWA 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 189 TPALQRPLAHGADLTVTSATKFIDGQGRVLGGvIAGSEALVRGPILSLCRTTGPTLSAFNAWVLLKSLETLPVRMAAHCD 268
Cdd:PRK08114  190 AGVLFKALDFGIDISIQAGTKYLVGHSDAMIG-TAVANARCWEQLRENSYLMGQMVDADTAYMTSRGLRTLGVRLRQHEE 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 269 HAEAVAAALALRGDLEAVTYPGLPSYRHRDIVQKQMSRAGALVTMDVG---SRARAMAVLDRLALFSRTANLGDTRSIV- 344
Cdd:PRK08114  269 SSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFTGSSGLFSFVLKkklTDEQLANYLDNFSLFSMAYSWGGFESLIl 348

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1308823969 345 -THPASTTHSRMTPEARLaagvSEGLVRLAIGLEDPRDLVADLA 387
Cdd:PRK08114  349 aNQPEEIAAIRPAGEVDF----TGTLIRLHIGLEDVDDLIADLA 388
AAT_like cd00609
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 68-258 2.92e-09

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.


Pssm-ID: 99734 [Multi-domain]  Cd Length: 350  Bit Score: 58.12  E-value: 2.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  68 FEDRYAALEGAEAAMGVASGMSAIFTTLLALLDQGDRVVcareVFGSTYLLVEQILPRWGIRPTFVPLGDLDAWRD---- 143
Cdd:cd00609    49 LGRRGGVDVPPEEIVVTNGAQEALSLLLRALLNPGDEVL----VPDPTYPGYEAAARLAGAEVVPVPLDEEGGFLLdlel 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 144 --ALKTP-TKLVLVETPSNPT---LEVVDLSALAEIVHAAGALMVVDNAFC--------TPALQRPLAHGADLTVTSATK 209
Cdd:cd00609   125 leAAKTPkTKLLYLNNPNNPTgavLSEEELEELAELAKKHGILIISDEAYAelvydgepPPALALLDAYERVIVLRSFSK 204

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1308823969 210 FIDGQG-RVlgGVIAGSEALVRGPILSLCRTTGPTLSAFNAWVLLKSLET 258
Cdd:cd00609   205 TFGLPGlRI--GYLIAPPEELLERLKKLLPYTTSGPSTLSQAAAAAALDD 252
HisC COG0079
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid ...
 84-187 1.22e-08

Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid transport and metabolism]; Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 439849 [Multi-domain]  Cd Length: 341  Bit Score: 55.91  E-value: 1.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  84 VASGMSAIFTTLL-ALLDQGDRVVcareVFGSTYLLVEQILPRWGIRPTFVPLG-----DLDAWRDALKTPTKLVLVETP 157
Cdd:COG0079    70 VGNGSDELIQLLArAFLGPGDEVL----VPEPTFSEYPIAARAAGAEVVEVPLDedfslDLDALLAAITERTDLVFLCNP 145

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1308823969 158 SNPTLEVVDLSALAEIV--HAAGALMVVDNAF 187
Cdd:COG0079   146 NNPTGTLLPREELEALLeaLPADGLVVVDEAY 177
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
68-231 1.14e-07

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 53.08  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  68 FEDRYAALEGAEAAMGVASGMSA-IFTTLLALLDQGDRVVcareVFGSTYLLVEQILPRWGIRPTFVPL-------GDLD 139
Cdd:pfam00155  52 LGRSPVLKLDREAAVVFGSGAGAnIEALIFLLANPGDAIL----VPAPTYASYIRIARLAGGEVVRYPLydsndfhLDFD 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 140 AWRDALKTPTKLVLVETPSNPT-----LEvvDLSALAEIVHAAGALMVVDNAF-------CTPALQRPLA--HGADLTVT 205
Cdd:pfam00155 128 ALEAALKEKPKVVLHTSPHNPTgtvatLE--ELEKLLDLAKEHNILLLVDEAYagfvfgsPDAVATRALLaeGPNLLVVG 205

                         170       180
                  ....*....|....*....|....*..
gi 1308823969 206 SATKFIDGQG-RVlgGVIAGSEALVRG 231
Cdd:pfam00155 206 SFSKAFGLAGwRV--GYILGNAAVISQ 230
YnbB COG4100
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion ...
 69-242 1.65e-07

Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 443276  Cd Length: 409  Bit Score: 52.80  E-value: 1.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  69 EDRYAALEGAEAAMgV----ASGMSAIFTTLLALLDQGDRVVCareVFGSTYLLVEQI----------LPRWGIRPTFVP 134
Cdd:COG4100    63 ERVYADVFGAEDAL-VrpqiVSGTHAIALALFGVLRPGDELLS---ITGKPYDTLEEVigirgegqgsLKEFGISYRQVP 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 135 LG-----DLDAWRDALKTPTKLVLVETP----SNPTLEVVDLSALAEIVHAA--GALMVVDNA---FCtpALQRPLAHGA 200
Cdd:COG4100   139 LTedgkiDLEAIKKAINEKTKMVLIQRSrgysWRPSLTIEEIGEIIKFVKSInpDVICFVDNCygeFV--ETREPTEVGA 216

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1308823969 201 DLTVTSATKFIDGqGRVL-GGVIAGSEALVRgpiLSLCRTTGP 242
Cdd:COG4100   217 DLMAGSLIKNPGG-GLAPtGGYIAGRKDLVE---LAAYRLTAP 255
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 71-224 5.01e-07

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 49.30  E-value: 5.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  71 RYAALEGAEAAMGVASGMSAIFTTLLALLDQGDRVVCAREVFGSTYLLVEQILprwGIRPTFVPLGD-------LDAWRD 143
Cdd:cd01494    10 ARLLQPGNDKAVFVPSGTGANEAALLALLGPGDEVIVDANGHGSRYWVAAELA---GAKPVPVPVDDagyggldVAILEE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 144 ALKTP-TKLVLVETPSNPTLEVVDLSALAEIVHAAGALMVVDNAFCTPA----LQRPLAHGADLTVTSATKfidgqgrVL 218
Cdd:cd01494    87 LKAKPnVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGAspapGVLIPEGGADVVTFSLHK-------NL 159


                  ....*.
gi 1308823969 219 GGVIAG 224
Cdd:cd01494   160 GGEGGG 165
AspB COG0436
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ...
 85-186 5.38e-07

Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440205 [Multi-domain]  Cd Length: 387  Bit Score: 51.28  E-value: 5.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  85 ASGMSAIFTTLLALLDQGDRVVcareVFGSTYLLVEQILPRWGIRPTFVPLG-------DLDAWRDALKTPTKLVLVETP 157
Cdd:COG0436    97 NGAKEALALALLALLNPGDEVL----VPDPGYPSYRAAVRLAGGKPVPVPLDeengflpDPEALEAAITPRTKAIVLNSP 172

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1308823969 158 SNPTLEVV---DLSALAEIVHAAGALMVVDNA 186
Cdd:COG0436   173 NNPTGAVYsreELEALAELAREHDLLVISDEI 204
PRK09082 PRK09082
methionine aminotransferase; Validated
 68-184 5.42e-06

methionine aminotransferase; Validated


Pssm-ID: 181642 [Multi-domain]  Cd Length: 386  Bit Score: 47.99  E-value: 5.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  68 FEDRYAALEGAEAAMGVASGMS-AIFTTLLALLDQGDRVVCAREVFGSTYLLVEQIlprwGIRPTFVPLG------DLDA 140
Cdd:PRK09082   80 TARLYGRQYDADSEITVTAGATeALFAAILALVRPGDEVIVFDPSYDSYAPAIELA----GGRAVRVALQppdfrvDWQR 155

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1308823969 141 WRDALKTPTKLVLVETPSNPTLEVV---DLSALAEIVHAAGALMVVD 184
Cdd:PRK09082  156 FAAAISPRTRLIILNTPHNPSGTVWsaaDMRALWQLIAGTDIYVLSD 202
PRK07777 PRK07777
putative succinyldiaminopimelate transaminase DapC;
90-231 6.51e-06

putative succinyldiaminopimelate transaminase DapC;


Pssm-ID: 236095 [Multi-domain]  Cd Length: 387  Bit Score: 47.73  E-value: 6.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  90 AIFTTLLALLDQGDRVVCArEVFGSTYLLVeqILPRWGIRP--TFVPLG-----DLDAWRDALKTPTKLVLVETPSNPTL 162
Cdd:PRK07777   97 AIAAAVLGLVEPGDEVLLI-EPYYDSYAAV--IAMAGAHRVpvPLVPDGrgfalDLDALRAAVTPRTRALIVNSPHNPTG 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 163 EVV---DLSALAEIVHAAGALMVVDNAF----CTPALQRPLA-----HGADLTVTSATKFIDGQGRVLGGVIaGSEALVR 230
Cdd:PRK07777  174 TVLtaaELAAIAELAVEHDLLVITDEVYehlvFDGARHLPLAtlpgmRERTVTISSAAKTFNVTGWKIGWAC-GPAPLIA 252


                  .
gi 1308823969 231 G 231
Cdd:PRK07777  253 A 253
PRK05764 PRK05764
aspartate aminotransferase; Provisional
 84-184 1.12e-05

aspartate aminotransferase; Provisional


Pssm-ID: 235596  Cd Length: 393  Bit Score: 47.04  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  84 VASGMS-AIFTTLLALLDQGDRVvcarevfgstyllveqILPR--W----------GIRPTFVPLG-------DLDAWRD 143
Cdd:PRK05764   96 VTTGAKqALYNAFMALLDPGDEV----------------IIPApyWvsypemvklaGGVPVFVPTGeengfklTVEQLEA 159

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1308823969 144 ALKTPTKLVLVETPSNPTLEVV---DLSALAEIVHAAGALMVVD 184
Cdd:PRK05764  160 AITPKTKALILNSPSNPTGAVYspeELEAIADVAVEHDIWVLSD 203
PRK06108 PRK06108
pyridoxal phosphate-dependent aminotransferase;
69-173 1.47e-05

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180404  Cd Length: 382  Bit Score: 46.86  E-value: 1.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  69 EDRYAALEGAEAAMGVASGMSAIFTTLLALLDQGDRVVCAREVFGStylLVEQILPRwGIRPTFVPLG--------DLDA 140
Cdd:PRK06108   75 SRLHGVATPPERIAVTSSGVQALMLAAQALVGPGDEVVAVTPLWPN---LVAAPKIL-GARVVCVPLDfggggwtlDLDR 150

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1308823969 141 WRDALKTPTKLVLVETPSNPTLEVVDLSALAEI 173
Cdd:PRK06108  151 LLAAITPRTRALFINSPNNPTGWTASRDDLRAI 183
GLY1 COG2008
Threonine aldolase [Amino acid transport and metabolism];
63-231 4.06e-05

Threonine aldolase [Amino acid transport and metabolism];


Pssm-ID: 441611 [Multi-domain]  Cd Length: 333  Bit Score: 45.06  E-value: 4.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  63 PTVTMFEDRYAALEGAEAAMGVASGMSAIFTTLLALLDQGDRVVCAR------------EVF-GSTYLLVEqilprwGIR 129
Cdd:COG2008    35 PTVNRLEERVAELFGKEAALFVPSGTMANQLALRAHTRPGDEVICHEtahiyvdeggapEALsGVKLLPVP------GED 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 130 PTFvplgDLDAWRDALK------TPTKLVLVETPSN----PTLEvvDLSALAEIVHAAGALMVVD-----NAfcTPALQR 194
Cdd:COG2008   109 GKL----TPEDLEAAIRpgdvhfPQPGLVSLENTTEggtvYPLE--ELRAIAAVAREHGLPLHLDgarlfNA--AAALGV 180

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1308823969 195 PLA---HGADLTVTSATKfidGQGRVLGGVIAGSEALVRG 231
Cdd:COG2008   181 SLAeitAGVDSVSFGLTK---GLGAPGGAVLAGDPEFIEE 217
PRK00451 PRK00451
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
137-230 5.09e-05

aminomethyl-transferring glycine dehydrogenase subunit GcvPA;


Pssm-ID: 234769 [Multi-domain]  Cd Length: 447  Bit Score: 45.13  E-value: 5.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 137 DLDAWRDALKTPTKLVLVETPsN--PTLEvvDLSALAEIVHAAGALMVVdnaFCTP----ALQRPLAHGADLTVtsatkf 210
Cdd:PRK00451  193 DLEALEAAVDDDTAAVVVQYP-NffGVIE--DLEEIAEIAHAGGALFIV---GVDPvslgLLKPPGEYGADIVV------ 260

                          90       100       110
                  ....*....|....*....|....*....|
gi 1308823969 211 idGQGRVLG----------GVIAGSEALVR 230
Cdd:PRK00451  261 --GEGQPLGiplsfggpylGFFATRKKLVR 288
SufS_like cd06453
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ...
 127-228 7.66e-05

Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.


Pssm-ID: 99746 [Multi-domain]  Cd Length: 373  Bit Score: 44.38  E-value: 7.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 127 GIRPTFVPLG-----DLDAWRDALKTPTKLVLVETPSNPTLEVVDLSALAEIVHAAGALMVVDNAFCTPalQRPL---AH 198
Cdd:cd06453   113 GAKLKVVPVDddgqlDLEALEKLLTERTKLVAVTHVSNVLGTINPVKEIGEIAHEAGVPVLVDGAQSAG--HMPVdvqDL 190

                          90       100       110
                  ....*....|....*....|....*....|
gi 1308823969 199 GADLTVTSATKFIDGQGrvlGGVIAGSEAL 228
Cdd:cd06453   191 GCDFLAFSGHKMLGPTG---IGVLYGKEEL 217
PRK03321 PRK03321
putative aminotransferase; Provisional
 84-188 8.35e-05

putative aminotransferase; Provisional


Pssm-ID: 179559  Cd Length: 352  Bit Score: 44.19  E-value: 8.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  84 VASGMSAIFTTLL-ALLDQGDRVVCAREVFgSTYLLVEQILprwGIRPTFVPLG-----DLDAWRDALKTPTKLVLVETP 157
Cdd:PRK03321   79 VGCGSVALCQQLVqATAGPGDEVIFAWRSF-EAYPILVQVA---GATPVQVPLTpdhthDLDAMAAAITDRTRLIFVCNP 154

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1308823969 158 SNPTLEVVDLSALAEIVHA--AGALMVVDNAFC 188
Cdd:PRK03321  155 NNPTGTVVTPAELARFLDAvpADVLVVLDEAYV 187
PRK05166 PRK05166
histidinol-phosphate transaminase;
97-187 8.52e-05

histidinol-phosphate transaminase;


Pssm-ID: 179950  Cd Length: 371  Bit Score: 44.36  E-value: 8.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  97 ALLDQGDRVVCAREVFGstyllVEQILPR-WGIRPTFVPLG-----DLDAWRDALKTPTKLVLVETPSNPTLEVVDLSAL 170
Cdd:PRK05166  107 AVLRPGDRVVTLYPSFP-----LHEDYPTmMGARVERVTVTpdlgfDLDALCAAVARAPRMLMFSNPSNPVGSWLTADQL 181

                          90
                  ....*....|....*....
gi 1308823969 171 AEIVHA--AGALMVVDNAF 187
Cdd:PRK05166  182 ARVLDAtpPETLIVVDEAY 200
PRK08912 PRK08912
aminotransferase;
84-184 1.46e-04

aminotransferase;


Pssm-ID: 181580  Cd Length: 387  Bit Score: 43.43  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  84 VASGMS-AIFTTLLALLDQGDRVVCAREVFGStYLlveQILPRWGIRPTFVPLG------DLDAWRDALKTPTKLVLVET 156
Cdd:PRK08912   92 VTSGATeALAAALLALVEPGDEVVLFQPLYDA-YL---PLIRRAGGVPRLVRLEpphwrlPRAALAAAFSPRTKAVLLNN 167

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1308823969 157 PSNPTLEVV---DLSALAEIVHAAGALMVVD 184
Cdd:PRK08912  168 PLNPAGKVFpreELALLAEFCQRHDAVAICD 198
CsdA COG0520
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
125-184 2.43e-04

Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];


Pssm-ID: 440286 [Multi-domain]  Cd Length: 396  Bit Score: 42.82  E-value: 2.43e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1308823969 125 RWGIRPTFVPLG-----DLDAWRDALKTPTKLVLVETPSNPTLEVVDLSALAEIVHAAGALMVVD 184
Cdd:COG0520   126 RTGAEVRVIPLDedgelDLEALEALLTPRTKLVAVTHVSNVTGTVNPVKEIAALAHAHGALVLVD 190
PLN00175 PLN00175
aminotransferase family protein; Provisional
 79-161 1.22e-03

aminotransferase family protein; Provisional


Pssm-ID: 215089 [Multi-domain]  Cd Length: 413  Bit Score: 40.62  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  79 EAAMGVASGMS-AIFTTLLALLDQGDRVVcareVFGSTYLLVEQILPRWGIR--------PTF-VPLGDLDAwrdALKTP 148
Cdd:PLN00175  115 EKEVTVTSGCTeAIAATILGLINPGDEVI----LFAPFYDSYEATLSMAGAKiktvtlrpPDFaVPEDELKA---AFTSK 187

                          90
                  ....*....|...
gi 1308823969 149 TKLVLVETPSNPT 161
Cdd:PLN00175  188 TRAILINTPHNPT 200
PRK07324 PRK07324
transaminase; Validated
 90-202 1.31e-03

transaminase; Validated


Pssm-ID: 235989  Cd Length: 373  Bit Score: 40.69  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  90 AIFTTLLALLDQGDRVVcarevfgSTYLLVEQI--LPR--------WGIRPT--FVPlgDLDAWRDALKTPTKLVLVETP 157
Cdd:PRK07324   92 ANFLVLYALVEPGDHVI-------SVYPTYQQLydIPEslgaevdyWQLKEEngWLP--DLDELRRLVRPNTKLICINNA 162

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1308823969 158 SNPTLEVVD---LSALAEIVHAAGALMVVDNAFCTPALQRPLAHGADL 202
Cdd:PRK07324  163 NNPTGALMDrayLEEIVEIARSVDAYVLSDEVYRPLDEDGSTPSIADL 210
WecE COG0399
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis];
59-107 1.70e-03

dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440168  Cd Length: 364  Bit Score: 40.05  E-value: 1.70e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1308823969  59 RFTN-PTVTMFEDRYAALEGAEAAMGVASGMSAIFTTLLAL-LDQGDRVVC 107
Cdd:COG0399    25 WLTLgPEVKEFEEEFAAYLGVKHAVAVSSGTAALHLALRALgIGPGDEVIT 75
GcvP1 COG0403
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ...
 137-230 2.46e-03

Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440172 [Multi-domain]  Cd Length: 442  Bit Score: 39.63  E-value: 2.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969 137 DLDAWRDALKTPTKLVLVETPsNPTLEVVDLSALAEIVHAAGALMVVdnaFCTP----ALQRPLAHGADLTVtsatkfid 212
Cdd:COG0403   194 DLEALKALLDDDVAGVLVQYP-NFFGVIEDLRAIAEAAHAAGALVIV---AADPlslgLLKPPGELGADIVV-------- 261

                          90       100
                  ....*....|....*....|....*...
gi 1308823969 213 GQGRVLG----------GVIAGSEALVR 230
Cdd:COG0403   262 GEGQRLGvplgfggphaGFFATREKLVR 289
PRK06836 PRK06836
pyridoxal phosphate-dependent aminotransferase;
83-174 3.00e-03

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180720  Cd Length: 394  Bit Score: 39.41  E-value: 3.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  83 GVASGMSAIFTtllALLDQGDRVVCAREVFGSTYLLVEQilprWGIRPTFVPLG------DLDAWRDALKTPTKLVLVET 156
Cdd:PRK06836  104 GAAGALNVALK---AILNPGDEVIVFAPYFVEYRFYVDN----HGGKLVVVPTDtdtfqpDLDALEAAITPKTKAVIINS 176

                          90       100
                  ....*....|....*....|..
gi 1308823969 157 PSNPTlEVV----DLSALAEIV 174
Cdd:PRK06836  177 PNNPT-GVVyseeTLKALAALL 197
PRK05958 PRK05958
8-amino-7-oxononanoate synthase; Reviewed
 68-186 4.92e-03

8-amino-7-oxononanoate synthase; Reviewed


Pssm-ID: 235655 [Multi-domain]  Cd Length: 385  Bit Score: 38.60  E-value: 4.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308823969  68 FEDRYAALEGAEAAMGVASGMSAIFTTLLALLDQGDRVVCAREVFGStylLVEqilprwGIR---PTFV--PLGDLDAWR 142
Cdd:PRK05958   89 LEEELAEWFGAERALLFSSGYAANLAVLTALAGKGDLIVSDKLNHAS---LID------GARlsrARVRryPHNDVDALE 159

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1308823969 143 DALKTPT---KLVLVETpsnptlevV--------DLSALAEIVHAAGALMVVDNA 186
Cdd:PRK05958  160 ALLAKWRagrALIVTES--------VfsmdgdlaPLAELVALARRHGAWLLVDEA 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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