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Conserved domains on  [gi|1309149479|gb|PKQ14173|]
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dihydrolipoamide dehydrogenase [Alphaproteobacteria bacterium HGW-Alphaproteobacteria-1]

Protein Classification

methyltransferase domain-containing protein( domain architecture ID 1012635)

methyltransferase domain-containing protein similar to Caenorhabditis elegans small RNA 2'-O-methyltransferase that adds a 2'-O-methyl group at the 3'-end of PIWI-interacting RNAs (piRNAs) and small interfering RNAs (siRNAs) which are classes of regulatory RNAs that are involved in gene silencing in endogenous RNA interference (RNAi) pathways

EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:0032259
PubMed:  22536158

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiG super family cl34436
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 31-97 2.50e-07

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


The actual alignment was detected with superfamily member COG2227:

Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 47.32  E-value: 2.50e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1309149479  31 EFRSYTRYRYPRHDIC--KGPFTDEAGKVAQYDIILANQVWEHLDRPYAATQNVRAMLREGGWFWLAVP 97
Cdd:COG2227    57 EALEIARERAAELNVDfvQGDLEDLPLEDGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLLLLSTP 125
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 31-97 2.50e-07

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 47.32  E-value: 2.50e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1309149479  31 EFRSYTRYRYPRHDIC--KGPFTDEAGKVAQYDIILANQVWEHLDRPYAATQNVRAMLREGGWFWLAVP 97
Cdd:COG2227    57 EALEIARERAAELNVDfvQGDLEDLPLEDGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLLLLSTP 125
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 29-92 1.38e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 41.97  E-value: 1.38e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1309149479  29 RFEFRSYTRYRYPRHDICKGPFTDEAGkvAQYDIILANQVWEHLDRPYAATQNVRAMLREGGWF 92
Cdd:pfam08242  37 RERLAALGLLNAVRVELFQLDLGELDP--GSFDVVVASNVLHHLADPRAVLRNIRRLLKPGGVL 98
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 31-97 2.50e-07

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 47.32  E-value: 2.50e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1309149479  31 EFRSYTRYRYPRHDIC--KGPFTDEAGKVAQYDIILANQVWEHLDRPYAATQNVRAMLREGGWFWLAVP 97
Cdd:COG2227    57 EALEIARERAAELNVDfvQGDLEDLPLEDGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLLLLSTP 125
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 29-92 1.38e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 41.97  E-value: 1.38e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1309149479  29 RFEFRSYTRYRYPRHDICKGPFTDEAGkvAQYDIILANQVWEHLDRPYAATQNVRAMLREGGWF 92
Cdd:pfam08242  37 RERLAALGLLNAVRVELFQLDLGELDP--GSFDVVVASNVLHHLADPRAVLRNIRRLLKPGGVL 98
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 44-126 2.27e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 42.29  E-value: 2.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1309149479  44 DICKGPFTDEagkvaQYDIILANQVWEHLDRPYAATQNVRAMLREGGWFWLavpffipyhgdpVDCSRWSARGLSNLLIE 123
Cdd:COG2226    77 DAEDLPFPDG-----SFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVV------------VDFSPPDLAELEELLAE 139


                  ...
gi 1309149479 124 AGF 126
Cdd:COG2226   140 AGF 142
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 44-94 2.60e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 41.11  E-value: 2.60e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1309149479  44 DICKGPFTDEagkvaQYDIILANQVWEHLDRPYAATQNVRAMLREGGWFWL 94
Cdd:pfam08241  49 DAEDLPFPDN-----SFDLVLSSEVLHHVEDPERALREIARVLKPGGILII 94
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
43-97 4.50e-05

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 41.78  E-value: 4.50e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1309149479  43 HDICKG-PFTDEAgkvaqYDIILANQVWEHLDRPYA--ATQNVRAMLREGGWFWLAVP 97
Cdd:COG4627    34 GDLTDPlPFPDNS-----VDAIYSSHVLEHLDYEEAplALKECYRVLKPGGILRIVVP 86
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 59-126 2.04e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 39.72  E-value: 2.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1309149479  59 QYDIILANQVWEHLDRPYAATQNVRAMLREGGWF--------------WLAVPFFIPYHGdpvDCSRWSARGLSNLLIEA 124
Cdd:pfam13489  80 KFDVIVAREVLEHVPDPPALLRQIAALLKPGGLLllstplasdeadrlLLEWPYLRPRNG---HISLFSARSLKRLLEEA 156


                  ..
gi 1309149479 125 GF 126
Cdd:pfam13489 157 GF 158
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 19-90 1.15e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 36.77  E-value: 1.15e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1309149479  19 AAEISGKFGRRFEFRsytryrypRHDICKGPFTDEagkvaQYDIILANQVWEHLDRP--YAATQNVRAMLREGG 90
Cdd:pfam13649  36 ARERAAEAGLNVEFV--------QGDAEDLPFPDG-----SFDLVVSSGVLHHLPDPdlEAALREIARVLKPGG 96
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
58-92 1.77e-03

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 36.34  E-value: 1.77e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1309149479  58 AQYDIILANQVWEHLDRPYAATQNVRAMLREGGWF 92
Cdd:COG4106    62 EPFDLVVSNAALHWLPDHAALLARLAAALAPGGVL 96
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
50-128 4.43e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 36.13  E-value: 4.43e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1309149479  50 FTDEAGKVAQYDIILANQVWEHLDRPYAATQNVRAMLREGGWFWLAVPffipyHGDPVDCSRWSARGLSNLLIEAGFPE 128
Cdd:COG4976    98 LADLAEPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFIFSVE-----DADGSGRYAHSLDYVRDLLAAAGFEV 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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