NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1397853863|gb|PXW55406|]
View 

DHA1 family multidrug/chloramphenicol efflux transport protein-like MFS transporter [Grimontella sp. AG753]

Protein Classification

MFS transporter( domain architecture ID 11487773)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
7-409 0e+00

MdfA family multidrug efflux MFS transporter;


:

Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 653.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863   7 TGRRLGRQALLFPLCLVLYEFSTYIANDMIQPGMLAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVML 86
Cdd:PRK15402    3 PLARLGRQALLFPLCLVLFEFATYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVML 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  87 TGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVH 166
Cdd:PRK15402   83 AGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIH 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 167 AAPWQGMFVLFAALAAVAFVGLQRAMPETATRLGEPLSLKALWHDYALVMKNVRFVAGALATGFVSLPLLAWIAQSPIII 246
Cdd:PRK15402  163 VLPWRGMFVLFAALAALSFFGLWRAMPETAGRVGEKLSLKELGRDYKLVLKNRRFVAGALALGLVSLPLLAWIALSPVIL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 247 ISGEQLSSYEYGLLQVPIFGALIVGNLVLARLTSRRTVRSLIILGGWPIAAGLILAAVATVASSHAYLWMTAGLSLYAFG 326
Cdd:PRK15402  243 ISGEQLSSYEYGLLQVPVFGALIAGNLTLARLTSRRPLRSLIRMGLWPMVAGLLLAALATVISSHAYLWLTAGLSLYAFG 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 327 IGLANAGLVRLTLFASDVSKGAVSAAMGMLQMLIFTVGIEVSKHAYLVGGNGLFSLFNLLNGLFWLGLMVIFLRDKSVGN 406
Cdd:PRK15402  323 IGLANAGLYRLTLFSSDVSKGTVSAAMGMLSMLIFTVGIELSKHAYLGGGNGLFNLFNLANGLLWLLLVRIFLKDKPMGN 402


                  ...
gi 1397853863 407 SLE 409
Cdd:PRK15402  403 AHE 405
 
Name Accession Description Interval E-value
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
7-409 0e+00

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 653.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863   7 TGRRLGRQALLFPLCLVLYEFSTYIANDMIQPGMLAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVML 86
Cdd:PRK15402    3 PLARLGRQALLFPLCLVLFEFATYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVML 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  87 TGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVH 166
Cdd:PRK15402   83 AGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIH 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 167 AAPWQGMFVLFAALAAVAFVGLQRAMPETATRLGEPLSLKALWHDYALVMKNVRFVAGALATGFVSLPLLAWIAQSPIII 246
Cdd:PRK15402  163 VLPWRGMFVLFAALAALSFFGLWRAMPETAGRVGEKLSLKELGRDYKLVLKNRRFVAGALALGLVSLPLLAWIALSPVIL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 247 ISGEQLSSYEYGLLQVPIFGALIVGNLVLARLTSRRTVRSLIILGGWPIAAGLILAAVATVASSHAYLWMTAGLSLYAFG 326
Cdd:PRK15402  243 ISGEQLSSYEYGLLQVPVFGALIAGNLTLARLTSRRPLRSLIRMGLWPMVAGLLLAALATVISSHAYLWLTAGLSLYAFG 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 327 IGLANAGLVRLTLFASDVSKGAVSAAMGMLQMLIFTVGIEVSKHAYLVGGNGLFSLFNLLNGLFWLGLMVIFLRDKSVGN 406
Cdd:PRK15402  323 IGLANAGLYRLTLFSSDVSKGTVSAAMGMLSMLIFTVGIELSKHAYLGGGNGLFNLFNLANGLLWLLLVRIFLKDKPMGN 402


                  ...
gi 1397853863 407 SLE 409
Cdd:PRK15402  403 AHE 405
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 19-398 9.09e-76

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 240.17  E-value: 9.09e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  19 PLCLVLYEFSTYIANDMIQPGMLAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLA 98
Cdd:cd17320     1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  99 TLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHAAPWQGMFVLFA 178
Cdd:cd17320    81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 179 ALAAVAFVGLQRAMPETATRLGEPLSLKALWHDYALVMKNVRFVAGALATGFVSLPLLAWIAQSPIIIISGEQLSSYEYG 258
Cdd:cd17320   161 LLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 259 LLQVPIFGALIVGNLVLARLTSRRTVRSLIILGGWPIAAGLILAAVATVASSHAYLWMTAGLSLYAFGIGLANAGLVRLT 338
Cdd:cd17320   241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLA 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 339 LFASDVSKGAVSAAMGMLQMLIFTVGIEVSKHAYLvGGNGLFSLFNLLNGLFWLGLMVIF 398
Cdd:cd17320   321 LEPFPHVAGTASALLGFLQFLIGALAGALVGLLPN-GTALPMGLLILVLGLLALLLLILL 379
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
13-359 5.82e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 107.37  E-value: 5.82e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  13 RQALLFPLCLVLYEFSTYIANDMIQPGMLAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWF 92
Cdd:COG2814     6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  93 VVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHAAPWQG 172
Cdd:COG2814    86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 173 MFVLFAALAAVAFVGLQRAMPETatrlgEPLSLKALWHDYALVMKNVRFVAGALATGFVSLPLLAWIAQSPIIIISGEQL 252
Cdd:COG2814   166 VFLVNAVLALLALLLLLRLLPES-----RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 253 SSYEYGLLQVPIFGALIVGNLVLARLTSRRTVRSLIILGGWPIAAGLILAAVAtvassHAYLWMTAGLSLYAFGIGLANA 332
Cdd:COG2814   241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA-----GSLWLLLLALFLLGFGFGLLFP 315

                         330       340
                  ....*....|....*....|....*...
gi 1397853863 333 GLVRLTL-FASDVSKGAVSAAMGMLQML 359
Cdd:COG2814   316 LLQALVAeLAPPEARGRASGLYNSAFFL 343
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 34-369 7.29e-26

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 107.85  E-value: 7.29e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  34 DMIQPGMLAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRF 113
Cdd:TIGR00710  22 DMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRF 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 114 LQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHAAPWQGMFVLFAALAAVAFVGLQRAMP 193
Cdd:TIGR00710 102 VQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILP 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 194 ETATRLGEpLSLKALWHDYALVMKNVRFVAGALATGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIVGNL 273
Cdd:TIGR00710 182 ETLPYEAR-IQISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGF 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 274 VLARLTSRRTVRSLIILGGWPIAAGLILAAVATVASSHAYLWMTAGLSLYAFGIGLANAGLVRLTLFASDVSKGAVSAAM 353
Cdd:TIGR00710 261 LNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAGTASALF 340

                         330
                  ....*....|....*..
gi 1397853863 354 GMLQM-LIFTVGIEVSK 369
Cdd:TIGR00710 341 GTLRLvLGAIVGYLVSL 357
MFS_1 pfam07690
Major Facilitator Superfamily;
58-365 1.89e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 70.91  E-value: 1.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:pfam07690  38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPE 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 138 VCIKITALMANVALIAPLLGPLVGAAWVHAAPWQGMFVLFAALAAVAFVGLQRAMPETATRLGEPLSLKALWHDYALVMK 217
Cdd:pfam07690 118 ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKAL 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 218 NVRFVAGALATGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIVGNLVLARLTSRRTVRSLIILGGwpIAA 297
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAL--LLL 275

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1397853863 298 GLILAAVATVASSHAYLWMTAGLSLYAFGIGLANAGLvrLTLFASDVSKGAVSAAMGMLQMLIFTVGI 365
Cdd:pfam07690 276 ILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPAL--NALVSDLAPKEERGTASGLYNTAGSLGGA 341
 
Name Accession Description Interval E-value
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
7-409 0e+00

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 653.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863   7 TGRRLGRQALLFPLCLVLYEFSTYIANDMIQPGMLAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVML 86
Cdd:PRK15402    3 PLARLGRQALLFPLCLVLFEFATYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVML 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  87 TGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVH 166
Cdd:PRK15402   83 AGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIH 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 167 AAPWQGMFVLFAALAAVAFVGLQRAMPETATRLGEPLSLKALWHDYALVMKNVRFVAGALATGFVSLPLLAWIAQSPIII 246
Cdd:PRK15402  163 VLPWRGMFVLFAALAALSFFGLWRAMPETAGRVGEKLSLKELGRDYKLVLKNRRFVAGALALGLVSLPLLAWIALSPVIL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 247 ISGEQLSSYEYGLLQVPIFGALIVGNLVLARLTSRRTVRSLIILGGWPIAAGLILAAVATVASSHAYLWMTAGLSLYAFG 326
Cdd:PRK15402  243 ISGEQLSSYEYGLLQVPVFGALIAGNLTLARLTSRRPLRSLIRMGLWPMVAGLLLAALATVISSHAYLWLTAGLSLYAFG 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 327 IGLANAGLVRLTLFASDVSKGAVSAAMGMLQMLIFTVGIEVSKHAYLVGGNGLFSLFNLLNGLFWLGLMVIFLRDKSVGN 406
Cdd:PRK15402  323 IGLANAGLYRLTLFSSDVSKGTVSAAMGMLSMLIFTVGIELSKHAYLGGGNGLFNLFNLANGLLWLLLVRIFLKDKPMGN 402


                  ...
gi 1397853863 407 SLE 409
Cdd:PRK15402  403 AHE 405
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
9-390 1.98e-100

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 304.83  E-value: 1.98e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863   9 RRLGRQA--LLFPLCLVLYEFSTYIANDMIQPGMLAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVML 86
Cdd:PRK15403    6 RFFARHAatLFFPMALILYDFAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLI 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  87 TGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVH 166
Cdd:PRK15403   86 TGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMH 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 167 AAPWQGMFVLFAALAAVAFVGLQRAMPETATRLGEPLSLKALWHDYALVMKNVRFVAGALATGFVSLPLLAWIAQSPIII 246
Cdd:PRK15403  166 FVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAVPFSAKSVLRDFRNVFRNRLFLTGAATLSLSYIPMMSWVAVSPVIL 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 247 ISGEQLSSYEYGLLQVPIFGALIVGNLVLARLTSRRTvRSLIILGGWPIA-AGLILAAVATVASSHAYLWMTAGLSLYAF 325
Cdd:PRK15403  246 IDAGGMTTSQFAWTQVPVFGAVIVANAIVARFVKDPT-EPRFIWRAVPIQlVGLALLIVGNLLWPHVWLWSVLGTSLYAF 324

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1397853863 326 GIGLANAGLVRLTLFASDVSKGAVSAAMGMLQMLIFTVGIEVSKHAYLVGGNGLFSLFNLLNGLF 390
Cdd:PRK15403  325 GIGLIFPTLFRFTLFSNNLPKGTVSASLNMVILMVMAVSVEIGRWLWFNGGRLPFHLLAVVAGVI 389
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 19-398 9.09e-76

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 240.17  E-value: 9.09e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  19 PLCLVLYEFSTYIANDMIQPGMLAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLA 98
Cdd:cd17320     1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  99 TLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHAAPWQGMFVLFA 178
Cdd:cd17320    81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 179 ALAAVAFVGLQRAMPETATRLGEPLSLKALWHDYALVMKNVRFVAGALATGFVSLPLLAWIAQSPIIIISGEQLSSYEYG 258
Cdd:cd17320   161 LLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 259 LLQVPIFGALIVGNLVLARLTSRRTVRSLIILGGWPIAAGLILAAVATVASSHAYLWMTAGLSLYAFGIGLANAGLVRLT 338
Cdd:cd17320   241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLA 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 339 LFASDVSKGAVSAAMGMLQMLIFTVGIEVSKHAYLvGGNGLFSLFNLLNGLFWLGLMVIF 398
Cdd:cd17320   321 LEPFPHVAGTASALLGFLQFLIGALAGALVGLLPN-GTALPMGLLILVLGLLALLLLILL 379
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
13-359 5.82e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 107.37  E-value: 5.82e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  13 RQALLFPLCLVLYEFSTYIANDMIQPGMLAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWF 92
Cdd:COG2814     6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  93 VVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHAAPWQG 172
Cdd:COG2814    86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 173 MFVLFAALAAVAFVGLQRAMPETatrlgEPLSLKALWHDYALVMKNVRFVAGALATGFVSLPLLAWIAQSPIIIISGEQL 252
Cdd:COG2814   166 VFLVNAVLALLALLLLLRLLPES-----RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 253 SSYEYGLLQVPIFGALIVGNLVLARLTSRRTVRSLIILGGWPIAAGLILAAVAtvassHAYLWMTAGLSLYAFGIGLANA 332
Cdd:COG2814   241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA-----GSLWLLLLALFLLGFGFGLLFP 315

                         330       340
                  ....*....|....*....|....*...
gi 1397853863 333 GLVRLTL-FASDVSKGAVSAAMGMLQML 359
Cdd:COG2814   316 LLQALVAeLAPPEARGRASGLYNSAFFL 343
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 34-369 7.29e-26

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 107.85  E-value: 7.29e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  34 DMIQPGMLAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRF 113
Cdd:TIGR00710  22 DMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRF 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 114 LQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHAAPWQGMFVLFAALAAVAFVGLQRAMP 193
Cdd:TIGR00710 102 VQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILP 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 194 ETATRLGEpLSLKALWHDYALVMKNVRFVAGALATGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIVGNL 273
Cdd:TIGR00710 182 ETLPYEAR-IQISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGF 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 274 VLARLTSRRTVRSLIILGGWPIAAGLILAAVATVASSHAYLWMTAGLSLYAFGIGLANAGLVRLTLFASDVSKGAVSAAM 353
Cdd:TIGR00710 261 LNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAGTASALF 340

                         330
                  ....*....|....*..
gi 1397853863 354 GMLQM-LIFTVGIEVSK 369
Cdd:TIGR00710 341 GTLRLvLGAIVGYLVSL 357
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 22-398 3.63e-21

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 94.03  E-value: 3.63e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  22 LVLYEFSTYIANDMIQPGMLAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLL 101
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 102 AQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWV--HAAPWQGMFVLFAA 179
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 180 LAAVAFVGLQRAMPET---ATRLGEPLSLKALWHDYALVMKNVRFVAGALATGFVSLPLLAWIAQSPIIIISGEQLSSYE 256
Cdd:cd06174   161 LALLAAILLLLVVPDPpesARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 257 YGLLQVPIFGALIVGNLVLARLTSRRTVRSLIILggwpiaAGLILAAVATVASSHAYLWMTAGLSLYAFGIGLANAGLVR 336
Cdd:cd06174   241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLL------IGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLS 314

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1397853863 337 LTLFASDVSKGAVSAAMGMLQMLIFTVGIEVSKHA--YLVGGNGLFSLFNLLNGLFWLGLMVIF 398
Cdd:cd06174   315 FALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAgfLLAATFGLTGAFLVLAVLLLLAAILLL 378
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
31-163 1.22e-15

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 77.65  E-value: 1.22e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  31 IANDMIQPGMLAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTL 110
Cdd:PRK11102    5 LAIDMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIY 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1397853863 111 LRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAA 163
Cdd:PRK11102   85 MRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGW 137
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
30-315 1.69e-15

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 77.63  E-value: 1.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  30 YIANDMIQPGMLAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFT 109
Cdd:PRK11043   19 FLATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 110 LLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITA-LMANVALiAPLLGPLVGAAWVHAAPWQGMFVLFAALAAVAFVGL 188
Cdd:PRK11043   99 VLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFAtIMPLVAL-SPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPT 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 189 QRAMPETATRLGEPLSLkalwhDYALVMKNVRFVAGALATGFVSLPLLAWIAQSPIIIisgEQL--SSYEYGLLQVPIFG 266
Cdd:PRK11043  178 LRLKPSKKARKQSQDAL-----TFKQLLKSKTYLGNVLIFAACSAAFFAWLTGSPFIL---EQMgySPADIGLSYVPQTI 249

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1397853863 267 ALIVG----NLVLARLTSRRTVRSLIILGGWPIAAgLILAAVATVASSHAYLW 315
Cdd:PRK11043  250 AFLVGgygcRAALQKWGGEQLLPWLLVLFAVSVIA-IWLASLLSHPSLVPLLI 301
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 27-400 4.23e-15

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 76.07  E-value: 4.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  27 FSTYIA---NDMIQPGMLAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQ 103
Cdd:cd17474     6 FATLLAvlgVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 104 TIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVhAAPWQGMFVLFAALAAV 183
Cdd:cd17474    86 SFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 184 AFVGLQRAMPETATRlGEPLSLKALWhDYALVMKNVRFVAGALATGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVP 263
Cdd:cd17474   165 AFLAILFLLPEPKEK-AKSSSATKLR-DLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAG 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 264 IFGALIVGNLVLARLTSRRtvrsliILGGWPIAAGLILAAVATVA--SSHAYLWMTAGLSLYAFGIGLANAGL-VRLTLF 340
Cdd:cd17474   243 WSVLLALGSLFVGRLLKKR------FGARRILVIGLLLYALSLLLlgFVPSLALLLIAIVLFGLGLGLNLPLLtTLVTEL 316

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 341 ASDVSKGAVSAAMGMLQMLIFTVGIEVSkhAYLVGGNGLFSLFNLLNGLFWLGLMVIFLR 400
Cdd:cd17474   317 APEEERGTASSLYNFVRFLGQAVGPLLF--GLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 49-368 7.33e-14

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 72.21  E-value: 7.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  49 AGIEWVPTSMTAYLAGGMFLqwlLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYA 128
Cdd:cd17321    31 SQLQWVVNAYLLAFAALLLL---AGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLA 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 129 AIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHAAPWQGMFVLFAalaavafvglqrampetatrlgePLSLKAL 208
Cdd:cd17321   108 LIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINV-----------------------PIGLVAL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 209 WhdyaLVmknVRFVAGALATGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIVGNLVLARLTSRRTVRSLI 288
Cdd:cd17321   165 L----LA---RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 289 ILGGWPIAAGLILAAVATVASShaYLWMTAGLSLYAFGIGLANAGLVRLTLFASDVSK-GAVSAAMGMLQMLIFTVGIEV 367
Cdd:cd17321   238 VAGLLLTAVGLLLLALLGADSS--VWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKaGAASGILNTARQLGGALGVAL 315


                  .
gi 1397853863 368 S 368
Cdd:cd17321   316 L 316
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 27-306 1.07e-13

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 71.00  E-value: 1.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  27 FSTYIANDMIQPGMLAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIE 106
Cdd:COG0477    24 FLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPE 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 107 QFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHAAPWQGMFVLFAALAAVAFV 186
Cdd:COG0477   104 LLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALV 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 187 GlqrampetATRLGEPLSLKALWHDYALVMKNVRFVAGALATGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFG 266
Cdd:COG0477   184 L--------RLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLA 255

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1397853863 267 ALIVGNLVLARLTSRRTVRSLIILGGWPIAAGLILAAVAT 306
Cdd:COG0477   256 LLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
58-365 1.37e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 71.44  E-value: 1.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:COG2271    51 ASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPK 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 138 VCIKITALMANVALIAPLLGPLVGAAWVHAAPWQGMFVLFAALaavafvglqrampetatrlgeplslkalwhdyALVMK 217
Cdd:COG2271   131 ERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLP--------------------------------GLLLA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 218 NVRFVAGALATGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIVGNLVLARLTSRrtvrsLIILGGWPIAA 297
Cdd:COG2271   179 LLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR-----LGRRRKLVLAI 253

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 298 GLILAAVATVASSHA--YLWMTAGLSLYAFGIGLANAglVRLTLFASDVSKGAVSAAMGMLQMLIFTVGI 365
Cdd:COG2271   254 GLLLAALALLLLALLpsPALAIALLFLAGFGLGGAFG--LLWALAAELFPKKARGTASGLVNTFGFLGGA 321
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 44-400 1.41e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 71.45  E-value: 1.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  44 VEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIG 123
Cdd:cd17325    23 AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVW 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 124 AVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHAAPWQGMFVLFAALAAVAFVGLQRAMPETA-TRLGEP 202
Cdd:cd17325   103 PAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRpPPNKRA 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 203 LSLKALWHDYALVMKNVRFVAGALATGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIVGNLVLARLTSRR 282
Cdd:cd17325   183 VSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 283 TVRSLIILGGWPIAAGLILAAVATvasshAYLWMTAGLSLYAFGIGLAN-AGLVRLTLFASDVSKGAVSAAMGMLQMLIF 361
Cdd:cd17325   263 GRKPLILIGLLLSAVALLLLPLAT-----SFWLLLLLLALLGLGLGLVFpATLALLADIVPPEGRGTAMGLFNTAFSLGM 337

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1397853863 362 TVGIEVSkhAYLVGGNGLFSLFnLLNGLFWLGLMVIFLR 400
Cdd:cd17325   338 VLGPLLG--GFLYDAFGFATPF-LAAAALLLLAAVLFLL 373
MFS_1 pfam07690
Major Facilitator Superfamily;
58-365 1.89e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 70.91  E-value: 1.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:pfam07690  38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPE 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 138 VCIKITALMANVALIAPLLGPLVGAAWVHAAPWQGMFVLFAALAAVAFVGLQRAMPETATRLGEPLSLKALWHDYALVMK 217
Cdd:pfam07690 118 ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKAL 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 218 NVRFVAGALATGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIVGNLVLARLTSRRTVRSLIILGGwpIAA 297
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAL--LLL 275

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1397853863 298 GLILAAVATVASSHAYLWMTAGLSLYAFGIGLANAGLvrLTLFASDVSKGAVSAAMGMLQMLIFTVGI 365
Cdd:pfam07690 276 ILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPAL--NALVSDLAPKEERGTASGLYNTAGSLGGA 341
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 27-170 4.64e-11

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 63.75  E-value: 4.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  27 FSTYIANDMIQPGMLAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIE 106
Cdd:cd17323     9 FVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIA 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1397853863 107 QFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHAAPW 170
Cdd:cd17323    89 MLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGW 152
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
34-173 8.11e-10

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 60.04  E-value: 8.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  34 DMIQPGMLAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRF 113
Cdd:PRK10473   20 DMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRF 99

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 114 LQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHAAPWQGM 173
Cdd:PRK10473  100 LQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSL 159
emrD PRK11652
multidrug transporter EmrD;
58-195 1.04e-09

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 59.92  E-value: 1.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:PRK11652   49 MAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGT 128

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1397853863 138 VCIKITALMANVALIAPLLGPLVGAAWVHAAPWQGMFVLFAALAAVAFVGLQRAMPET 195
Cdd:PRK11652  129 QLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPET 186
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 58-365 1.28e-09

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 59.49  E-value: 1.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:cd17324    40 VSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPE 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 138 VCIKITALMANVALIAPLLGPLVGAAWVHAAPWQGMFVLFAALAAVAFVGLQRAMPETATRLGEPLSLKAlwhDYALVMK 217
Cdd:cd17324   120 KRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLS---SLLLLLR 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 218 NVRFVAGALATGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIVGNLVLARLTSRRTVRSLIILGGWPIAA 297
Cdd:cd17324   197 NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1397853863 298 GLILAAVAtvassHAYLWMTAGLSLYAFGIGLANAGlvrLTLFASDVSKGAVSAAMGmLQMLIFTVGI 365
Cdd:cd17324   277 LLLLTLLG-----PSPLLLLVGLVLWGLGFFAAHSA---LQTRVLRLAPEARGLASS-LYLAAYNLGG 335
2_A_01_02 TIGR00880
Multidrug resistance protein;
59-170 5.83e-09

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 54.19  E-value: 5.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  59 TAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAV 138
Cdd:TIGR00880   5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1397853863 139 CIKITALMANVALIAPLLGPLVGAAWVHAAPW 170
Cdd:TIGR00880  85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGW 116
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 75-367 3.66e-08

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 54.89  E-value: 3.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  75 LSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAP 154
Cdd:cd17503    54 LADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAP 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 155 LLGPLVGAAWVHAAPWQGMFVLFAALAAVAFVglqrampetatrLGEPLSLKALwhdyalvmKNVRFVAGALATGFVSLP 234
Cdd:cd17503   134 AIGPTLGGWLTDNLSWRWIFYINLPIGILALL------------LAPLLDLRLF--------KDRNFTLGLLLSFLLGLG 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 235 LLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIVGNLVLARLTSRRTVRSLIILGGWPIAAGLILAAVATVASShaYL 314
Cdd:cd17503   194 LFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTS--LW 271

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1397853863 315 WMTAGLSLYAFGIGLANAGLVRLTLfaSDVSK---GAVSAAMGMLQMLIFTVGIEV 367
Cdd:cd17503   272 LIILPLFIRGLGMGLVFMPLNTLAL--NSLPPeqiGDATALFNTIRQLGGSIGTAL 325
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
58-332 5.55e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 54.50  E-value: 5.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:COG2223    46 FAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPD 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 138 VCIKITALMANVALIAPLLGPLVGAAWVHAAPWQGMFVLFAALAAVAFVGLQRAMPETATrlGEPLSLKALWHDYALVMK 217
Cdd:COG2223   126 RRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPA--GAAAAAKASLRDQLEALR 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 218 NVRFVAGALATGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIVGNLVLARLTSRRTVRSLIILGGWPIAA 297
Cdd:COG2223   204 DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMAL 283

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1397853863 298 GLILAAVATvassHAYLWMTAGLSLYAFGIGLANA 332
Cdd:COG2223   284 GLLLLALAL----GSLWLFLVLFLLLGLALGGGNG 314
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 35-364 9.91e-08

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 53.35  E-value: 9.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  35 MIQPGMLAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFL 114
Cdd:cd17504    14 MLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRAL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 115 QGISLCFIGaVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHAAPWQGMFVLFAALAAVAFVglqrAMPE 194
Cdd:cd17504    94 QGIGGAVFP-LAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAA----LVPL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 195 TATRLgepLSLKALWHDYALVMknvrFVAGALATGFVSLPLLawiAQSPIIIISGeqLSSYEYGLLQVPIFGALIVGNLV 274
Cdd:cd17504   169 IDLRL---LRRRNVLLANITAL----LAGFGMFMVFQLLPQL---LQLPTPTGFG--LGITEAGLLLLPGALVMLIAGPL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 275 LARLTSRRTVRSLIILGGwpIAAGLILAAVATVASSHAylWMTAGLSLYAFGIGLANAGLVRLTLFAsdVSKGAVSAAMG 354
Cdd:cd17504   237 AGRLIARVGPRRVLLIGL--VISAVGLLLLALLHSSLW--ALVVALLLIGIGLGLAFASLPNIVVES--VPPDRTGIATG 310

                         330
                  ....*....|
gi 1397853863 355 MLQmLIFTVG 364
Cdd:cd17504   311 MNT-VLRTIG 319
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 58-119 1.65e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 52.59  E-value: 1.65e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1397853863  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISL 119
Cdd:cd17365    40 GSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGL 101
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 62-134 2.56e-07

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 52.30  E-value: 2.56e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1397853863  62 LAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESF 134
Cdd:cd17371    44 LAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYV 116
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 53-132 4.67e-07

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 51.43  E-value: 4.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  53 WVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQE 132
Cdd:cd17317    26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 58-228 9.52e-07

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 50.43  E-value: 9.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:TIGR00895  58 FSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKR 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 138 VCIKITALMANVALIAPLLGPLVGAAWVHAAPWQGMFVLFAALAAVAFVGLQRAMPETATRLGEPLSLKALWHDYALVMK 217
Cdd:TIGR00895 138 FRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQ 217

                         170
                  ....*....|.
gi 1397853863 218 NVRFVAGALAT 228
Cdd:TIGR00895 218 MQAEAQSALPE 228
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 41-334 1.31e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 49.91  E-value: 1.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  41 LAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLC 120
Cdd:cd17316    25 LAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 121 FIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHAAP----WQGMFVlfaalaavafvglqrampeta 196
Cdd:cd17316   105 GEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRILFL--------------------- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 197 trLGEPLSLKALWHDYALVMknvrfvaGALATGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIVGNLVLA 276
Cdd:cd17316   164 --IGALPALLALLLRRRTLL-------LILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAG 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1397853863 277 RLTSRRTVRSLIILGGWPIAAGLILAAVATVASShayLWMTAGLSLYAFGIGLANAGL 334
Cdd:cd17316   235 LLSDRIGRKKTLVIGLILSGILALPLFYLLSGSP---TLLLLLLFILSFFVGGVWGAL 289
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 53-364 1.58e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 49.92  E-value: 1.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  53 WVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLT-----GVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGY 127
Cdd:cd06173    35 LVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQ 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 128 AAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHAAPWQGMFVLFAALAAVAFVGLQ--RAMPETATRLGEPLSL 205
Cdd:cd06173   115 ALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLfiRRPPPAAPGESSSLLL 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 206 KALWHDYALVMKNVRFVAGALATGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIVGNLVLARLTSRRTVR 285
Cdd:cd06173   195 RDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRG 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 286 SLIILGGWPIAAGLILAAVATvasshaYLWMTAGLSLyAFGIGLANAGLVRLTLFASDVSK---GAVSAAMGMLQMLIFT 362
Cdd:cd06173   275 RLLLIGALLLGLALLVLGLSP------SLWLLLAALF-LLGLAGGLFNVPLNTLLQLRVPDelrGRVFSVYNALNSGAMP 347


                  ..
gi 1397853863 363 VG 364
Cdd:cd06173   348 LG 349
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 59-375 1.78e-06

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 49.48  E-value: 1.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  59 TAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAV 138
Cdd:cd17502    37 TAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRE 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 139 CIKITALMANVALIAPLLGPLVGAAWVHAAPWQgmfvlfaalaavafvglqrampeTATRLGEPLSLkalwhdYALVMkn 218
Cdd:cd17502   117 RGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWR-----------------------WCFYINLPIGG------LALAL-- 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 219 VR-FVAGALATGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIVGNLVLARLTSR-RTVRSLIILGGwpiA 296
Cdd:cd17502   166 LRtILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKtGRYKPLIVIGT---I 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 297 AGLILAAVATVASSHAYLWMTAGLS-LYAFGIGLANAGLVRLTLFASDVSK-GAVSAAMGMLQMLIFTVGIEVsKHAYLV 374
Cdd:cd17502   243 LMSVGAGLLTTLTLDTSKWLLIGYLiLLGLGLGIGFQQPLVAVQNAVPPADvGVATATNTFFRSLGGTLGVAI-TDVFLV 321


                  .
gi 1397853863 375 G 375
Cdd:cd17502   322 A 322
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 67-164 2.64e-06

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 49.14  E-value: 2.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  67 FLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGIslCFIGAVGYAAIQESFEEAVCIKITALM 146
Cdd:cd17472    47 IFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLADLTREENRTKAMALI 124

                          90       100
                  ....*....|....*....|..
gi 1397853863 147 ANV----ALIAPLLGPLVGAAW 164
Cdd:cd17472   125 GASigiaFAISMVLGPLLAAHL 146
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 27-161 1.14e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 47.20  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  27 FSTYIANDMIQPGMLAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIE 106
Cdd:cd17489     6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1397853863 107 QFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVG 161
Cdd:cd17489    86 LLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALG 140
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 58-356 2.23e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 46.02  E-value: 2.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:cd17319    44 ASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPAR 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 138 VCIKITALMANVALIAPLLGPLVGAAWVHAAPWQGMFVLFAAlaavafvglqrampetatrlgepLSLKALWHDYALVMK 217
Cdd:cd17319   124 ERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGL-----------------------LGLLLAVLWWFYLRQ 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 218 NVRFVAGALATGFVSLPLLAWIaqsPIIIISGEQLSSYEYGLLQVPIFGALIVGNLVLARLTSRRTVRSliilGGWPIAA 297
Cdd:cd17319   181 VWGLALGYFGINYALYGLLTWL---PTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGA----RRLVIII 253

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1397853863 298 GLILAAVATVASSHAY-LWMT-AGLSLYAFGIGLANAGL-VRLTLFASDVSKGAVSAAMGML 356
Cdd:cd17319   254 GLLLAAVGLLLAYLTTsPVVAvILLSLAGFGIGAASPVFwSLPADLLPGEAAATAGGLINSG 315
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 52-117 9.89e-05

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 44.00  E-value: 9.89e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1397853863  52 EWVPTSMTAY---LAGGMFLQWLL------GPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGI 117
Cdd:cd17377    30 EWFLVGNAAYkvsLASSFFFAGVLigvvsfGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGV 104
MFS_YdiM_like cd17396
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ...
 72-172 8.09e-04

Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340954 [Multi-domain]  Cd Length: 384  Bit Score: 41.18  E-value: 8.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  72 LGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVAL 151
Cdd:cd17396    55 AGVLSDKFGRKPSVLLGMVLYALFFVGILFSPNLIIAYVFALLAGAANSFLDTGTYPALMEAFPKASGSANILVKAFVSF 134

                          90       100
                  ....*....|....*....|.
gi 1397853863 152 IAPLLgPLVGAAWVHAAPWQG 172
Cdd:cd17396   135 GQFLL-PFIIAFLAANNLWYG 154
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 36-361 1.02e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 41.02  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  36 IQPGMLAVVEQYQAGIE-WVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFL 114
Cdd:cd17473    18 IAPALPAIAQHFVPNSElLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRAL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 115 QGISLCFIGAVGYAAIQESFEEAVCIK----ITALMANVALIAPLLGPLVGAA------WVHAAPWqgmfvlfaalaaVA 184
Cdd:cd17473    98 LGIGVAGIMTLATALIGDYFEGEERAKmlglQSAAMSLGGVVFLLLGGALAEIgwrapfLVYLLAL------------PV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 185 FVGLQRAMPETATRLGEPLSLKALWhdyALVMKNVRFVAGALATGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPI 264
Cdd:cd17473   166 LILVLLFLPEPARKSKSAASPGAAT---AAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIA 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 265 FGALIVGNLVLARLTSRRTVRSLIILGGWPIAAGLILAAVAtvassHAYLWMTAGLSLYAFGIGLANAGLvrLTLFASDV 344
Cdd:cd17473   243 SLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALA-----SGLWVVLLGAILAGLGFGLLLPTL--NSWAMSLV 315

                         330
                  ....*....|....*..
gi 1397853863 345 SKGAVSAAMGMLQMLIF 361
Cdd:cd17473   316 PPELRGRAMGIVTSAFF 332
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
20-131 1.20e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.04  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  20 LCLVLYEFSTYIANDMIQPGMLAVVEQY-QAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLA 98
Cdd:COG2211   231 LLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1397853863  99 TLLAQTiEQFTLLrflqgISLCFIGAVGYAAIQ 131
Cdd:COG2211   311 LFFLGP-GNLWLL-----LVLAALAGIGLGAIL 337
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 55-119 1.58e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 40.35  E-value: 1.58e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1397853863  55 PTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISL 119
Cdd:cd17374    38 SVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAV 102
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 22-306 3.05e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.52  E-value: 3.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  22 LVLYEFSTYIANDMIQPGM-LAVVEQYQAGIEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATL 100
Cdd:cd17329     4 LLIGSFLNRLGFFMVWPFMaIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 101 LAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGaAWVHAAPWQGMFVLFAAL 180
Cdd:cd17329    84 FAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLG-GLLLLYSFRLLFLAAAVL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863 181 AAVAFVGLQRAMPETATRLGEPLSLKALWhDYALVMKNVRFVAGALATGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLL 260
Cdd:cd17329   163 FLLAALVLLFLLPETRPKRRAAEKTEILR-GYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLL 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1397853863 261 qVPIFGALIV-GNLVLARLTSRRTVRSLIILGGWPIAAGLILAAVAT 306
Cdd:cd17329   242 -LALNALLIVlLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFAN 287
Sugar_tr pfam00083
Sugar (and other) transporter;
60-119 6.09e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 38.79  E-value: 6.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1397853863  60 AYLAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVT---CLATLLAQTIEQFTLLRFLQGISL 119
Cdd:pfam00083  54 IFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGavlQGAAKGKWSVYQLIVGRVLVGIGV 116
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 53-170 6.54e-03

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 38.40  E-value: 6.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  53 WVPTSMTayLAGGMFLqWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQE 132
Cdd:cd17476    37 WLAASYS--LTVGTFI-LIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGR 113

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1397853863 133 SFEEAVCIKIT-ALMANVALIAPLLGPLVGAAWVHAAPW 170
Cdd:cd17476   114 TYPPGPRKNIVfSLFGATAPLGFALGGVFGGLFAQLAWW 152
PRK10504 PRK10504
putative transporter; Provisional
 73-170 8.54e-03

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 38.17  E-value: 8.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397853863  73 GPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAvciKITALMANVAL- 151
Cdd:PRK10504   66 GWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPRE---QYMAAMTFVTLp 142

                          90       100
                  ....*....|....*....|.
gi 1397853863 152 --IAPLLGPLVGAAWVHAAPW 170
Cdd:PRK10504  143 gqVGPLLGPALGGLLVEYASW 163
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 62-128 9.57e-03

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 37.91  E-value: 9.57e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1397853863  62 LAGGMFLQWLLGPLSDRIGRRPVMLTGVVWFVVTCLATLLAQTIEQFTLLRFLQGISLCFIGAVGYA 128
Cdd:cd17444    46 LVGLIFGYLITGCLADWFGRRPVLLFSVVFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILSLYA 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH