|
Name |
Accession |
Description |
Interval |
E-value |
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
1-544 |
3.18e-148 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 436.13 E-value: 3.18e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 1 MSKNTIIRGTALLAGASFISRLLGMLYTIPFESLVGATGGKLYGLAYGPYTIFISLSTIGIPLAVSKFVAKYNSLGDYRT 80
Cdd:COG5841 1 MKKQSFLKGALILTAAGLISKILGAIYRIPLQNIIGDEGFGLYQMAYPIYGLFLTLATAGIPVAISKLVAEYNALGDYKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 81 SFRMYQVALKLMIISGIVSFAVLFGGAELLAQLYIPDQaegisvgDVAMVIRMVSFALLIIPATSITRGFFQGFESMGPT 160
Cdd:COG5841 81 ARRIFRVSLLLLLILGLVFFLLLFFGAPFIARLLLGDP-------RAYYSLRALAPALLIVPVMSVLRGYFQGLQNMTPT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 161 AISQVIEQVARIAFLLTAVYLIINVfdgSTTTAVGFATFSAFIGAIASLFVLLWYWKKRKTHLDKYIKQQRiKSEPLTTK 240
Cdd:COG5841 154 AVSQVIEQIVRVIFILLLAYLLLPY---GLEYAAAGATFGAVIGALAGLLVLLYYYRKRKKKLKRLLEKSK-TKSKESSK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 241 QLFRELFSYAGPFVFVGLAIPLYQQIDAITFSRTLVNTGVGQLEIDHAFSNINLYGHKLIMIPITLATGMSLATLPTLTK 320
Cdd:COG5841 230 DILKELLRIAIPITLSSLVLPLFQLIDSFTVPRRLQAAGLSASEATSLYGILSGMAQPLVNLPTVLATALATSLVPAISE 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 321 SFVDKKRQLLFKQINQSIQVIIFIVLPAVVGMSLLSENIWGAFYGISAyldfNARILAWYAPVALFFALFTVTSSILQGI 400
Cdd:COG5841 310 AFAKKDRKLVRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGNPE----GGGILAILAPSAIFLSLQQVTTGILQGL 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 401 NEQRYAIYSLGLGLALKALINVPLLSLLGPIGAVVGTLIASATTVVSNLIRVKYSIGFSLKAVsKRSVLMGIFTLIMALT 480
Cdd:COG5841 386 GKQKIPVINLLIGLLVKIILNYLLVPLFGIYGAALATVIGYLVAAILNLAALKKYTGFKLDLR-RRLLKPLLASLIMGIV 464
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1397887295 481 VFGTRVAISPLLHysDGRLANVLILAITTTIGAYVYLWLSYHSTLMERVMGGRMHKLGRIFGKR 544
Cdd:COG5841 465 VLLLYRLLSLFLP--ESRLGALLATLIAVLVGAIVYLLLLLKLGLITKEELRRLPKGGKKLARL 526
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
11-458 |
1.00e-127 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 380.27 E-value: 1.00e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 11 ALLAGASFISRLLGMLYTIPFESLVGATGGKLYGLAYGPYTIFISLSTIGIPLAVSKFVAKYNSLGDYRTSFRMYQVALK 90
Cdd:cd13124 1 LILTIAGLISKILGAIYRIPLQNIIGDEGMGLYQMAYPIYGIFLTLATAGIPVAISKLVAEYNALGDYKGARRIFRVSLI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 91 LMIISGIVSFAVLFGGAELLAQLYIPDQaegisvgDVAMVIRMVSFALLIIPATSITRGFFQGFESMGPTAISQVIEQVA 170
Cdd:cd13124 81 LLLILGLVFFLLLFFGAPFLAQLLLGDP-------RLAPVIRALAPAILIVPLLSVLRGYFQGLQNMTPTAVSQVIEQIV 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 171 RIAFLLTAVYLIINVfDGSTTTAVGFATFSAFIGAIASLFVLLWYWKKRKTHLDKYIKQQRIKSEPltTKQLFRELFSYA 250
Cdd:cd13124 154 RVIVILVLAYLLLPV-GGGLYYAAAGATFGAVIGALAGLLVLLYYYRKKRRELKRLLRKSPRSKIS--TKEILKELLSYA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 251 GPFVFVGLAIPLYQQIDAITFSRTLVNTGVGQLEIDHAFSNINLYGHKLIMIPITLATGMSLATLPTLTKSFVDKKRQLL 330
Cdd:cd13124 231 IPITLSSLILPLLQLIDSFTVPRRLQAAGLSESEATALYGILTGRAQPLVQLPTVIATALSTSLVPAISEAYAKGDKKEL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 331 FKQINQSIQVIIFIVLPAVVGMSLLSENIWGAFYGISAyldfNARILAWYAPVALFFALFTVTSSILQGINEQRYAIYSL 410
Cdd:cd13124 311 RRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSE----GGLILQILAPSILFLSLQQVTAAILQGLGKVKIPVINL 386
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1397887295 411 GLGLALKALINVPLLSLLGPIGAVVGTLIASATTVVSNLIRVKYSIGF 458
Cdd:cd13124 387 LIGLLVKIVLNYVLIPIFGIYGAAIATVIGFLVAALLNLRALKKLLGF 434
|
|
| spore_V_B |
TIGR02900 |
stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial ... |
7-511 |
3.04e-37 |
|
stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial endopore formation program in Bacillus subtilis and various other Firmcutes. It is nearly universal among endospore-formers. Paralogs with rather high sequence similarity to SpoVB exist, including YkvU in B. subtilis and a number of proteins in the genus Clostridium. [Cellular processes, Sporulation and germination]
Pssm-ID: 274343 [Multi-domain] Cd Length: 488 Bit Score: 143.97 E-value: 3.04e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 7 IRGTALLAGASFISRLLGMLYTIPFESLVGATGGKLYGLAYGPYTIFISLSTIGIPLAVSKFVAKYNSLGDYRTSFRMYQ 86
Cdd:TIGR02900 2 LKGTFILTIANLITRILGFIFRIVLSRILGAEGVGLYGMAMPIYFLFITLTTGGLPVAISKFVAEASAKNDRKNIKKILK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 87 VALKLMIISGIVSFAVLFGGAELLAQLYIPDQAEGISvgdvamvIRMVSFALLIIPATSITRGFFQGFESMGPTAISQVI 166
Cdd:TIGR02900 82 VSLIFTLIWSLIVTAIVFLLSPFIASTLLKDERSLYS-------LLVICPAMPFIALSSVLKGYFQGISNMKPPAYIQVI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 167 EQVARIAFLLTAVYLIINVfdgSTTTAVGFATFSAFIGAIASLFVLLWYWKKRKTHLDKYIKQQRIKSepltTKQLFREL 246
Cdd:TIGR02900 155 EQIVRISVVALLISAFLPY---GLEYAVAGAYLSLVLGELVSLLYLYFFFKRKKSFSIRFPFFDYKSE----GKALLFDL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 247 FSYAGPFVFVGLAIPLYQQIDAITFSRTLVNTGVGQLEIDHAFSNINLYGHKLIMIPITLATGMSLATLPTLTKSFVDKK 326
Cdd:TIGR02900 228 FSVSLPLTLSRFIGSLLYFLETLLVPQRLVIAGVTYREATSLYGKLSGMAMPLLTFPAVITSSLSTALVPDISEAMAKKN 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 327 RQLLFKQINQSIQVIIFIVLPAVVGMSLLSENIWGAFYGISAYLDFnariLAWYAPVALFFALFTVTSSILQGINEQRYA 406
Cdd:TIGR02900 308 YSSIEKRINQAIKISLLLGLITTVILLVIPDELGALFYGRPDAGNF----IRVLAPSFPFLYFSAPLQSILQGLGKQKVA 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 407 IYSLGLGLALKALINVPLLSL--LGPIGAVVGTLIASATTVVSNLIRVKYSIGFSLKAVSkrsvlMGIFTLIMALTVFGt 484
Cdd:TIGR02900 384 LRNSLIGAIVKIILLFVLTSIpsINIYGYAITFIITSVLVTILNLAEIKKNIRITIDLSD-----FLIFALLGILVYLG- 457
|
490 500
....*....|....*....|....*..
gi 1397887295 485 rVAISPLLHYSDGRLANVLILAITTTI 511
Cdd:TIGR02900 458 -LSLLKYIIFNPNILINLLLIIILGFS 483
|
|
| Polysacc_synt |
pfam01943 |
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ... |
6-322 |
3.86e-21 |
|
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.
Pssm-ID: 426523 [Multi-domain] Cd Length: 274 Bit Score: 93.52 E-value: 3.86e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 6 IIRGTALLAGASFISRLLGMLYTIPFESLVGATGGKLYGLAYGPYTIFISLSTIGIPLAVSKFVAKYNSLGDYRTSFrmy 85
Cdd:pfam01943 1 LLKNVIVLLLSQLITYLLAFVTLPYLARILGPEGFGLYAFALAFVGLLTIFTDFGFNAALVREIAKYREKYELVSLY--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 86 qvalKLMIISGIVSFAVLFGGAELLAQLYipdqaegiSVGDVAMVIRMVSFALLIIPATSIT-RGFFQGFESMGPTAISQ 164
Cdd:pfam01943 78 ----WLNALLVKLVLVLLFLLLPLIAAFL--------GLPELAVLYRILALMFLLLPGVVQFrRGLFQGLERMKYALISQ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 165 VIEQVARIAFLLTAVYLIinvfdGSTTTAVGFATFSAFIGAIASLFVLLWYWKKRKTHLdkyikqqriksepltTKQLFR 244
Cdd:pfam01943 146 IVESLSRVILVFIAVFLP-----GDIVAALLYQVLAALVGGIIALAVLRKIFRPRFVFP---------------SLKLVR 205
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1397887295 245 ELFSYAGPFVFVGLAIPLYQQIDAITFSRTLVNTGVGqleidhafsNINLYGHKLIMIPITLATGMSLATLPTLTKSF 322
Cdd:pfam01943 206 KLLSFGAPLFISSLAISLYTYIDSILLGLLLGAGAVG---------IYNAAYQLLVAIQGLLNPIVTAVLFPVFSKLQ 274
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
1-544 |
3.18e-148 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 436.13 E-value: 3.18e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 1 MSKNTIIRGTALLAGASFISRLLGMLYTIPFESLVGATGGKLYGLAYGPYTIFISLSTIGIPLAVSKFVAKYNSLGDYRT 80
Cdd:COG5841 1 MKKQSFLKGALILTAAGLISKILGAIYRIPLQNIIGDEGFGLYQMAYPIYGLFLTLATAGIPVAISKLVAEYNALGDYKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 81 SFRMYQVALKLMIISGIVSFAVLFGGAELLAQLYIPDQaegisvgDVAMVIRMVSFALLIIPATSITRGFFQGFESMGPT 160
Cdd:COG5841 81 ARRIFRVSLLLLLILGLVFFLLLFFGAPFIARLLLGDP-------RAYYSLRALAPALLIVPVMSVLRGYFQGLQNMTPT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 161 AISQVIEQVARIAFLLTAVYLIINVfdgSTTTAVGFATFSAFIGAIASLFVLLWYWKKRKTHLDKYIKQQRiKSEPLTTK 240
Cdd:COG5841 154 AVSQVIEQIVRVIFILLLAYLLLPY---GLEYAAAGATFGAVIGALAGLLVLLYYYRKRKKKLKRLLEKSK-TKSKESSK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 241 QLFRELFSYAGPFVFVGLAIPLYQQIDAITFSRTLVNTGVGQLEIDHAFSNINLYGHKLIMIPITLATGMSLATLPTLTK 320
Cdd:COG5841 230 DILKELLRIAIPITLSSLVLPLFQLIDSFTVPRRLQAAGLSASEATSLYGILSGMAQPLVNLPTVLATALATSLVPAISE 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 321 SFVDKKRQLLFKQINQSIQVIIFIVLPAVVGMSLLSENIWGAFYGISAyldfNARILAWYAPVALFFALFTVTSSILQGI 400
Cdd:COG5841 310 AFAKKDRKLVRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGNPE----GGGILAILAPSAIFLSLQQVTTGILQGL 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 401 NEQRYAIYSLGLGLALKALINVPLLSLLGPIGAVVGTLIASATTVVSNLIRVKYSIGFSLKAVsKRSVLMGIFTLIMALT 480
Cdd:COG5841 386 GKQKIPVINLLIGLLVKIILNYLLVPLFGIYGAALATVIGYLVAAILNLAALKKYTGFKLDLR-RRLLKPLLASLIMGIV 464
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1397887295 481 VFGTRVAISPLLHysDGRLANVLILAITTTIGAYVYLWLSYHSTLMERVMGGRMHKLGRIFGKR 544
Cdd:COG5841 465 VLLLYRLLSLFLP--ESRLGALLATLIAVLVGAIVYLLLLLKLGLITKEELRRLPKGGKKLARL 526
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
11-458 |
1.00e-127 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 380.27 E-value: 1.00e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 11 ALLAGASFISRLLGMLYTIPFESLVGATGGKLYGLAYGPYTIFISLSTIGIPLAVSKFVAKYNSLGDYRTSFRMYQVALK 90
Cdd:cd13124 1 LILTIAGLISKILGAIYRIPLQNIIGDEGMGLYQMAYPIYGIFLTLATAGIPVAISKLVAEYNALGDYKGARRIFRVSLI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 91 LMIISGIVSFAVLFGGAELLAQLYIPDQaegisvgDVAMVIRMVSFALLIIPATSITRGFFQGFESMGPTAISQVIEQVA 170
Cdd:cd13124 81 LLLILGLVFFLLLFFGAPFLAQLLLGDP-------RLAPVIRALAPAILIVPLLSVLRGYFQGLQNMTPTAVSQVIEQIV 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 171 RIAFLLTAVYLIINVfDGSTTTAVGFATFSAFIGAIASLFVLLWYWKKRKTHLDKYIKQQRIKSEPltTKQLFRELFSYA 250
Cdd:cd13124 154 RVIVILVLAYLLLPV-GGGLYYAAAGATFGAVIGALAGLLVLLYYYRKKRRELKRLLRKSPRSKIS--TKEILKELLSYA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 251 GPFVFVGLAIPLYQQIDAITFSRTLVNTGVGQLEIDHAFSNINLYGHKLIMIPITLATGMSLATLPTLTKSFVDKKRQLL 330
Cdd:cd13124 231 IPITLSSLILPLLQLIDSFTVPRRLQAAGLSESEATALYGILTGRAQPLVQLPTVIATALSTSLVPAISEAYAKGDKKEL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 331 FKQINQSIQVIIFIVLPAVVGMSLLSENIWGAFYGISAyldfNARILAWYAPVALFFALFTVTSSILQGINEQRYAIYSL 410
Cdd:cd13124 311 RRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSE----GGLILQILAPSILFLSLQQVTAAILQGLGKVKIPVINL 386
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1397887295 411 GLGLALKALINVPLLSLLGPIGAVVGTLIASATTVVSNLIRVKYSIGF 458
Cdd:cd13124 387 LIGLLVKIVLNYVLIPIFGIYGAAIATVIGFLVAALLNLRALKKLLGF 434
|
|
| spore_V_B |
TIGR02900 |
stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial ... |
7-511 |
3.04e-37 |
|
stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial endopore formation program in Bacillus subtilis and various other Firmcutes. It is nearly universal among endospore-formers. Paralogs with rather high sequence similarity to SpoVB exist, including YkvU in B. subtilis and a number of proteins in the genus Clostridium. [Cellular processes, Sporulation and germination]
Pssm-ID: 274343 [Multi-domain] Cd Length: 488 Bit Score: 143.97 E-value: 3.04e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 7 IRGTALLAGASFISRLLGMLYTIPFESLVGATGGKLYGLAYGPYTIFISLSTIGIPLAVSKFVAKYNSLGDYRTSFRMYQ 86
Cdd:TIGR02900 2 LKGTFILTIANLITRILGFIFRIVLSRILGAEGVGLYGMAMPIYFLFITLTTGGLPVAISKFVAEASAKNDRKNIKKILK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 87 VALKLMIISGIVSFAVLFGGAELLAQLYIPDQAEGISvgdvamvIRMVSFALLIIPATSITRGFFQGFESMGPTAISQVI 166
Cdd:TIGR02900 82 VSLIFTLIWSLIVTAIVFLLSPFIASTLLKDERSLYS-------LLVICPAMPFIALSSVLKGYFQGISNMKPPAYIQVI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 167 EQVARIAFLLTAVYLIINVfdgSTTTAVGFATFSAFIGAIASLFVLLWYWKKRKTHLDKYIKQQRIKSepltTKQLFREL 246
Cdd:TIGR02900 155 EQIVRISVVALLISAFLPY---GLEYAVAGAYLSLVLGELVSLLYLYFFFKRKKSFSIRFPFFDYKSE----GKALLFDL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 247 FSYAGPFVFVGLAIPLYQQIDAITFSRTLVNTGVGQLEIDHAFSNINLYGHKLIMIPITLATGMSLATLPTLTKSFVDKK 326
Cdd:TIGR02900 228 FSVSLPLTLSRFIGSLLYFLETLLVPQRLVIAGVTYREATSLYGKLSGMAMPLLTFPAVITSSLSTALVPDISEAMAKKN 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 327 RQLLFKQINQSIQVIIFIVLPAVVGMSLLSENIWGAFYGISAYLDFnariLAWYAPVALFFALFTVTSSILQGINEQRYA 406
Cdd:TIGR02900 308 YSSIEKRINQAIKISLLLGLITTVILLVIPDELGALFYGRPDAGNF----IRVLAPSFPFLYFSAPLQSILQGLGKQKVA 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 407 IYSLGLGLALKALINVPLLSL--LGPIGAVVGTLIASATTVVSNLIRVKYSIGFSLKAVSkrsvlMGIFTLIMALTVFGt 484
Cdd:TIGR02900 384 LRNSLIGAIVKIILLFVLTSIpsINIYGYAITFIITSVLVTILNLAEIKKNIRITIDLSD-----FLIFALLGILVYLG- 457
|
490 500
....*....|....*....|....*..
gi 1397887295 485 rVAISPLLHYSDGRLANVLILAITTTI 511
Cdd:TIGR02900 458 -LSLLKYIIFNPNILINLLLIIILGFS 483
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
6-453 |
4.60e-28 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 116.10 E-value: 4.60e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 6 IIRGTALLAGASFISRLLGMLYTIPFESLVGATGGKLYGLAYGPYTIFISLSTIGIPLAVSKFVAKY--NSLGDYRTSfr 83
Cdd:cd13128 1 LAKNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIARYrkEKIREIIST-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 84 myqvALKLMIISGIVSFAVLFggaeLLAQLYIPDQAEgisvgdVAMVIRMVSFALLIIPATSITRGFFQGFESMGPTAIS 163
Cdd:cd13128 79 ----SLVLKLILGILALLLLF----LFAFLIAFYDPE------LVLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVIA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 164 QVIEQVARIAFLLTAVYliinvFDGSTTTAVGFATFSAFIGAIASLFVllwywkkrkthldkYIKQQRIKSEPLTTKQLF 243
Cdd:cd13128 145 RIIESVLSLILALILVL-----LGGGLIGFALAYLIASVLSAILLLYI--------------YRKKILLPKFFSFDLKLA 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 244 RELFSYAGPFVFVGLAIPLYQQIDAITFSRTLVNTGVGqleidhafsnINLYGHKLIMIPITLATGMSLATLPTLTKSFV 323
Cdd:cd13128 206 KELLRFSIPLALSGIFSLIYTRIDTIMLGYFLGDAAVG----------IYNAAYRIAELLLFIPSAISTALFPRISELYK 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 324 dKKRQLLFKQINQSIQVIIFIVLPAVVGMSLLSENIWGAFYGiSAYLDfNARILAWYAPVALFFALFTVTSSILQGINEQ 403
Cdd:cd13128 276 -NDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFG-EEYLP-AALVLQILAWGFLFIFLNGIFGSILQAIGKQ 352
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 1397887295 404 RYAIYSLGLGLALKALINVPLLSLLGPIGAVVGTLIASATTVVSNLIRVK 453
Cdd:cd13128 353 KLTLKILLIGALLNVILNLLLIPKYGIIGAAIATLISEFIIFILLLYLLK 402
|
|
| Polysacc_synt |
pfam01943 |
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ... |
6-322 |
3.86e-21 |
|
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.
Pssm-ID: 426523 [Multi-domain] Cd Length: 274 Bit Score: 93.52 E-value: 3.86e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 6 IIRGTALLAGASFISRLLGMLYTIPFESLVGATGGKLYGLAYGPYTIFISLSTIGIPLAVSKFVAKYNSLGDYRTSFrmy 85
Cdd:pfam01943 1 LLKNVIVLLLSQLITYLLAFVTLPYLARILGPEGFGLYAFALAFVGLLTIFTDFGFNAALVREIAKYREKYELVSLY--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 86 qvalKLMIISGIVSFAVLFGGAELLAQLYipdqaegiSVGDVAMVIRMVSFALLIIPATSIT-RGFFQGFESMGPTAISQ 164
Cdd:pfam01943 78 ----WLNALLVKLVLVLLFLLLPLIAAFL--------GLPELAVLYRILALMFLLLPGVVQFrRGLFQGLERMKYALISQ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 165 VIEQVARIAFLLTAVYLIinvfdGSTTTAVGFATFSAFIGAIASLFVLLWYWKKRKTHLdkyikqqriksepltTKQLFR 244
Cdd:pfam01943 146 IVESLSRVILVFIAVFLP-----GDIVAALLYQVLAALVGGIIALAVLRKIFRPRFVFP---------------SLKLVR 205
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1397887295 245 ELFSYAGPFVFVGLAIPLYQQIDAITFSRTLVNTGVGqleidhafsNINLYGHKLIMIPITLATGMSLATLPTLTKSF 322
Cdd:pfam01943 206 KLLSFGAPLFISSLAISLYTYIDSILLGLLLGAGAVG---------IYNAAYQLLVAIQGLLNPIVTAVLFPVFSKLQ 274
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
3-446 |
1.89e-17 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 84.23 E-value: 1.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 3 KNTIIRGTALLAGASFISRLLGMLYTIPFESLVGATGGKLYGLAYGPYTIFISLSTIGIPLAVSKFVAKYNSLGDYRTsf 82
Cdd:COG2244 1 LKKLLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIVALLSVLADLGLSTALVRFIAEYREEELRRL-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 83 rmYQVALKLMIISGIVSFAVLFGGAELLAQLYipdqaegiSVGDVAMVIRMVSFALLIIPATSITRGFFQGFESMGPTAI 162
Cdd:COG2244 79 --LSTALLLRLLLSLLLALLLLLLAPFIAALL--------GEPELALLLLLLALALLLSALSAVLLALLRGLERFKLLAL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 163 SQVIEQVARIAFLLTAVYLIINVfdgstttavgfatfsafigaiaslfvllWYWkkrkthldkyikqqrikseplttkql 242
Cdd:COG2244 149 INILSSLLSLLLALLLALLGLGL----------------------------WGL-------------------------- 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 243 freLFSYAGPFVFVGLAIPLYQQIDAITFSRTLVNTGVGQLEIdhafsninlyGHKLIMIPITLATGMSLATLPTLTKSF 322
Cdd:COG2244 175 ---VLKYSLPLLLSGLLGLLLTNLDRLLLGALLGPAAVGIYSA----------AYRLASLLLLLITALSQVLFPRLSRLL 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 323 VDKKRQLLFKQINQSIQVIIFIVLPAVVGMSLLSENIWGAFYGiSAYLDfNARILAWYAPVALFFALFTVTSSILQGINE 402
Cdd:COG2244 242 AEGDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFG-PEYAE-AAPVLPILALGALFLALSGVLSNLLLALGR 319
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1397887295 403 QRYAIYSLGLGLALKALINVPLLSLLGPIGAVVGTLIASATTVV 446
Cdd:COG2244 320 TRLLLIISLIGAVLNLVLNLLLIPRYGLVGAAIATLLSYLVLLL 363
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
7-521 |
4.81e-16 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 80.96 E-value: 4.81e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 7 IRGTALLAGASFISRLLGMLYTIPFESLVGATGGK-LYGLAYG-PYTIFI-----SLSTIGIPLavskfVAKYNSLGDYR 79
Cdd:COG0728 1 LRAALIVAIGTLLSRILGFVRDILIAAAFGAGAVAdAFFVAFRiPNLLRRlfaegALSAAFVPV-----LAEALEKEGEE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 80 TSFRMYQVALKLMIISGIVSFAVLFGGAELLAQLYIPdqaeGISVGDVAMVI---RMVSFALLIIPATSITRGFFQGFES 156
Cdd:COG0728 76 EARRFASRVLTLLLLVLLVLTLLGILFAPLLVKLLAP----GFDPEKFALAValtRIMFPYILFIGLSALLGGVLNARGR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 157 MGPTAISQVIEQVARIAFLLtavyliinVFDGSTTTAVGFATFSAFIGAIASLFVLLWYWKKRKTHLDKYIkqqrikseP 236
Cdd:COG0728 152 FAAPALAPVLLNLVIIAGLL--------LLAPLFGPGIYALAWGVLLGGVLQLLIQLPALRRLGLRLRPRF--------D 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 237 LTTKQLfRELFSYAGPfVFVGLAIplyQQIDaitfsrTLVNTGVGQLEIDHAFSNINlYGHKLIMIPITL-ATGMSLATL 315
Cdd:COG0728 216 LRDPGV-RRVLKLMLP-ALLGVSV---SQIN------LLVDTILASFLPEGSVSALY-YADRLYQLPLGLfGVAIGTALL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 316 PTLTKSFVDKKRQLLFKQINQSIQVIIFIVLPAVVGMSLLSENI------WGAFYGISAYLdfNARILAWYAPVALFFAL 389
Cdd:COG0728 284 PRLSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIvrllfeRGAFTAEDTAL--TALALAAYALGLPAFAL 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 390 FTVTSSILQGINEQRYAIYSLGLGLALKALINVPLLSLLGPIGAVVGTLIASATTVVSNLIRVKYSIGF-SLKAVSKRSV 468
Cdd:COG0728 362 VKVLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVPPLGHAGLALATSLSALVNALLLLVLLRRRLGGlPLRGILRTLL 441
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 1397887295 469 LMGIFTLIMALTVFGTRVAISPLLHysDGRLANVLILAITTTIGAYVYLWLSY 521
Cdd:COG0728 442 KLLLASLVMGAVLWLLLRLLGDWLG--GGLLGRLLALALLILVGAAVYFALLL 492
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
14-446 |
1.37e-10 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 63.24 E-value: 1.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 14 AGASFISRLLGMLYTIPFESLVGATGGK-LYGLAYG-PYTIFI-----SLSTIGIPLavskFVAKYNSLGDYRTSFRMYQ 86
Cdd:cd13123 1 AIGTLLSRILGFVRDVLIAAAFGAGPLAdAFFVAFRiPNLLRRlfaegALSAAFVPV----FSEYLEKEGEEEARRFASR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 87 VALKLMIISGIVSFAVLFGgAELLAQLYIPdqaeGISVGDVAMVIRMV---SFALLIIPATSITRGFFQGFESMGPTAIS 163
Cdd:cd13123 77 VLTLLLLVLLLLTLLGILF-APLLVKLLAP----GFSGDKFELAVALTrimFPYLLFISLSALLGGILNAHGRFFAPALA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 164 QVIEQVARIAFLLTAVYliinvFDGSTTTAVGFATFsafIGAIASLFVLLWYWKKRKTHLdkyikqqrIKSEPLTTKQLf 243
Cdd:cd13123 152 PVLLNLVIIAGLLLLAP-----LFDLGIYALAWGVL---LGGVLQLLVQLPALRRLGFRF--------RPRLDFRDPGV- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 244 RELFSYAGPfVFVGLAIplyQQIDaitfsrTLVNTGVGQLEIDHAFSNINlYGHKLIMIPITL-ATGMSLATLPTLTKSF 322
Cdd:cd13123 215 RRVLKLMLP-ALLGVSV---SQIN------LLVDTILASFLPEGSISALY-YADRLYQLPLGIfGVAIATALLPRLSRLA 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 323 VDKKRQLLFKQINQSIQVIIFIVLPAVVGMSLLSENI------WGAFYGISAYLdfNARILAWYAPVALFFALFTVTSSI 396
Cdd:cd13123 284 AAGDLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAEPIvrllfeRGAFTAEDTLM--TASALAAYALGLPAFALVKLLSRA 361
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 1397887295 397 LQGINEQRYAIYSLGLGLALKALINVPLLSLLGPIGAVVGTLIASATTVV 446
Cdd:cd13123 362 FYALKDTKTPVKIAVIAVAVNILLNLLLIKPLGHVGLALATSLSAWVNAL 411
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
14-406 |
1.57e-10 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 63.11 E-value: 1.57e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 14 AGASFISRLLGMLYTIPFESLVGATGGKLYGL--AYGPYTIFISLSTIGIPLAVSKFVAKYNSLGDYRTSFRMYQVALKL 91
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAvgLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 92 MIISGIVSFAVLFGGAELLAQLYipdQAEGISVGDVAMVIRMVSFALLIIPATSITRGFFQGFESMGPTAISQVIEQVAR 171
Cdd:cd12082 81 AILLGLLLAALLLFFSPLILSLL---GAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLN 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 172 IAFLLTAVYLIinvfdGSTTTAVGFATFSAFIGAIASLFVLLWYWKKRKTHLDKYIKQQRIKseplttKQLFRELFSYAG 251
Cdd:cd12082 158 ILLDPLLIFGL-----GPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPD------LELLRRLLRIGL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 252 PFVFVGLAIPLYQQIDAITFSRTLVNTGVGQLEIdhafsninlyGHKLIMIPITLATGMSLATLPTLTKSFVDKKRQLLF 331
Cdd:cd12082 227 PSAIQNSLLSLGLLIIVAIVAAFGGAAALAAYTV----------AFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRAR 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1397887295 332 KQINQSIQVIIFIVLPAVVGMSLLSENIWGAFYGISAYLDFNARILAWYAPVALFFALFTVTSSILQGINEQRYA 406
Cdd:cd12082 297 RITWVALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKS 371
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
376-521 |
1.75e-10 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 59.12 E-value: 1.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 376 ILAWYAPVALFFALFTVTSSILQGINEQRYAIYSLGLGLALKALINVPLLSLLGPIGAVVGTLIASATTVVSNLIRVKYS 455
Cdd:pfam14667 1 VLQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLLIPLFGIVGAAIATVISLLVVALLNLYYLRRY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1397887295 456 IGFSLKavSKRSVLMGIFTLIMALTVFGTRVAISPLlhysdgrLANVLILAITTTIGAYVYLWLSY 521
Cdd:pfam14667 81 LGLRLL--LRRLLKPLLAALVMGIVVYLLLLLLGLL-------LGLALALLLAVLVGALVYLLLLL 137
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
85-463 |
4.03e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 55.57 E-value: 4.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 85 YQVALKLMIISGIVSFAVLFGGAELLAQLYipDQAEGISvgdvamVIRMVSFALLIIPATSITRGFFQ---GFESMGpta 161
Cdd:cd13127 71 LSTVFWLNLLLGLLLYLLLFLLAPLIAAFY--NEPELIP------LLRVLSLSFLLSGLGSVPRALLQrelRFKKLA--- 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 162 isqVIEQVARIAFLLTAVYLIINvfdgstttavGFATFSAFIGAIAS---LFVLLWYWKKRKTHldkyikqqriksePLT 238
Cdd:cd13127 140 ---IIELISTLVSGVVAIVLALL----------GFGVWALVAQQLVGalvSTVLLWILSRWRPR-------------LSF 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 239 TKQLFRELFSYAGPFVFVGLAIPLYQQIDAITFSRTLVNTGVGQLEIdhafsninlyGHKLIMIPITLATG-MSLATLPT 317
Cdd:cd13127 194 SLASLKELLSFGSKLLGSNLLNYFSRNLDNLIIGKFLGAAALGYYSR----------AYRLALLPVQNITGpITRVLFPA 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 318 LTKSFVDKKRqllFKQI-NQSIQVIIFIVLPAVVGMSLLSENIWGAFYG---ISAyldfnARILAWYAPVALFFALFTVT 393
Cdd:cd13127 264 LSRLQDDPER---LRRAyLKALRLLALITFPLMVGLALLAEPLVLLLLGekwLPA-----VPILQILALAGLFQPLSSLN 335
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1397887295 394 SSILQGINEQRYAIYslglGLALKALINVPLLSL---LGPIGAVVGTLIASATTVVSNLIRVKYSIGFSLKAV 463
Cdd:cd13127 336 GSLLLALGRTDLLLK----LGLIKAVLTVLALLIgipYGIIGVAIAYVIASLLSFPLNLYLAGRLIGISLLEL 404
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
91-481 |
9.88e-07 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 51.14 E-value: 9.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 91 LMIISGIVSFAVLFGgAELLAQLYIPDQAEGISVGDVAMVIRMVSFaLLIIPATSITRGFFQGFESMGPTAISQVIEQVA 170
Cdd:pfam03023 63 LILVLLLVTLIGILA-APWLIRLLAPGFDPETFSLAVSLLRITFPY-LLLVSLSAVFGAVLNARKKFFAPSFSPVLLNVG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 171 RIAFLLtavylIINVFDGSTTTAVGFATFsafIGAIASLFVLLWYWKKRKTHLdKYIKQQRikseplttKQLFRELFSYA 250
Cdd:pfam03023 141 VILTLL-----LLANYLGNAIYALAIGVL---IGGVLQLLVQLPFLKKAGLLL-KPRFGFR--------DKGLKRFLKLM 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 251 GPFVFVGLAIPLYQQIDaITFSRTLVNTGVGQLEidhafsninlYGHKLIMIPITL-ATGMSLATLPTLTKSFVDKKRQL 329
Cdd:pfam03023 204 LPTLLGVSVSQLNLLID-TFLASFLAPGSVSYLY----------YADRIYQLPLGIfGVSISTVLLPRLSRHAADGDWDE 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 330 LFKQINQSIQVIIFIVLPAVVGMSLLSENIWGAFYGISAYLDFN----ARILAWYAPVALFFALFTVTSSILQGINEQRY 405
Cdd:pfam03023 273 FRDLLDQAIRLTLLLMIPVSFGLLVLSIPIVSLLFERGNFSPEDvtatAEVLAAYALGLIPYALVKLLSRVFYAREDTKT 352
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1397887295 406 AIYSLGLGLALKALINVPLLSLLGPIGAVVGTLIASATTVVSNLIRVKYSIGFSLKAVSKRSVLMGIFTLIMALTV 481
Cdd:pfam03023 353 PFKISLISAVLNILLSLLLLPPLGVAGLALATSLSSLIGLVFLYYILRKRLGGFDLRGIKTFLASLVVPTALMAGV 428
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
60-218 |
2.50e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 43.67 E-value: 2.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 60 GIPLAVSKFVAKYNSLGDYRTSFRMYQVALKLMIISGIVSFAVLFGGAELLAQLYIPDqAEGISVGdvAMVIRMVSFALL 139
Cdd:cd13140 285 GFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASAIGLFATLLLFFFGEPLFSLFIPD-PETIAIG--VDYLRILGFSQL 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 140 IIPATSITRGFFQGF-ESMGPTAISqVIEQVARI--AFLLTAVYLIINvfdgstttAVGFA-TFSAFIGAIASLFVLLWY 215
Cdd:cd13140 362 FMCLEITTTGAFNGLgRTKPPAIIS-IVFNGLRIplALLLSPTGLGLN--------GIWWAiSISSILKGIILTIWFLLY 432
|
...
gi 1397887295 216 WKK 218
Cdd:cd13140 433 KKK 435
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
1-451 |
7.93e-04 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 42.05 E-value: 7.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 1 MSKNTIIRGTALLAGASFISRLLGMLYTIP---FESLVGATGgkLYGLAYG-PYTIFISLSTIGIPLAVSKFVAKYNSLG 76
Cdd:COG0534 1 LTEGPILKLLLRLALPIILGNLLQSLYGLVdtiFVGRLGTAA--LAAVGLAfPIFFLLIALGIGLGVGGTALVAQALGAG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 77 DYRTSFRMYQVALKLMIISGIVSFAVLFGGAELLAQLYipdQAEGISVGDVAMVIRMVSFALLIIPATSITRGFFQGFES 156
Cdd:COG0534 79 DREEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLL---GADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 157 MGPTAISQVIeqvariAFLLTAV--YLIINVFDGSTTTAvGFATFsafIGAIASLFVLLWYWKKRKTHLDKYIKQQRIKs 234
Cdd:COG0534 156 TKTPMIIMLI------GNVLNIVldPLLIFGGGLGVAGA-ALATV---ISQAVSALLLLYYLFRKRSLLRLRLRDLRPD- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 235 eplttKQLFRELFSYAGPFVFVGLAIPLYQqidaITFSRTLVNTGVGQLeidhAFSNInlyGHKLIMIPITLATGMSLAT 314
Cdd:COG0534 225 -----RKILKRILRIGLPAGLQQLAESLGF----LVLNALVARLGTAAV----AAYGI---ALRIESLAFMPALGLGQAA 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1397887295 315 LPTLTKSFVDKKRQLLFKQINQSIQVIIFIVLPAVVGMSLLSENIWGAFYGISAYLDFNARILAWYAPVALFFALFTVTS 394
Cdd:COG0534 289 QPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLS 368
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 1397887295 395 SILQGINEQRYAIYSLGLGLALKALINVPLLSL--LGPIGAVVGTLIASATTVVSNLIR 451
Cdd:COG0534 369 GALRGAGDTRFPMIISLLRLWLVRLPLAYLLAFlgLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| |
