NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2619680060|sp|Q05C16|]
View 

RecName: Full=Leucine-rich repeat-containing protein 63

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
306-469 1.25e-27

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 115.42  E-value: 1.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 306 ETITAMTNLAIVNCQVYGRNALNLKGFFILNCPDLTPLAF--QLIYLNLSFNDLHYFPTEILCLKNLQILKLRNNPIKEI 383
Cdd:COG4886    72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNltNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 384 PSEIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKL-NLT 462
Cdd:COG4886   152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLE 231


                  ....*..
gi 2619680060 463 KIQFENN 469
Cdd:COG4886   232 TLDLSNN 238
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
306-469 1.25e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 115.42  E-value: 1.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 306 ETITAMTNLAIVNCQVYGRNALNLKGFFILNCPDLTPLAF--QLIYLNLSFNDLHYFPTEILCLKNLQILKLRNNPIKEI 383
Cdd:COG4886    72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNltNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 384 PSEIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKL-NLT 462
Cdd:COG4886   152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLE 231


                  ....*..
gi 2619680060 463 KIQFENN 469
Cdd:COG4886   232 TLDLSNN 238
LRR_8 pfam13855
Leucine rich repeat;
393-449 2.12e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 2.12e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2619680060 393 LRIFTIAFNLITVLPIGLFS-LSYLEELDVSYNELTFI-PNEIQKLRSLEKLTVDGNEL 449
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 373-450 1.95e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.58  E-value: 1.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 373 LKLRNNPIK-EIPSEIQQLEFLRIFTIAFNLIT-VLPIGLFSLSYLEELDVSYNELT-FIPNEIQKLRSLEKLTVDGNEL 449
Cdd:PLN03150  423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502


                  .
gi 2619680060 450 S 450
Cdd:PLN03150  503 S 503
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 352-514 1.47e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 1.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 352 LSFNDLH--YFPTEILClKNLQILKLRNNPIKEIP------------------SEIQQLEFLRIFT---IAFNLITVLpI 408
Cdd:cd21340     7 LYLNDKNitKIDNLSLC-KNLKVLYLYDNKITKIEnlefltnlthlylqnnqiEKIENLENLVNLKklyLGGNRISVV-E 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 409 GLFSLSYLEELDVSY------NELTFIPNEIQKL-RSLEKLTVDGNELSfFPHGILKL-NLTKIQFENnfthpcfwrdNY 480
Cdd:cd21340    85 GLENLTNLEELHIENqrlppgEKLTFDPRSLAALsNSLRVLNISGNNID-SLEPLAPLrNLEQLDASN----------NQ 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2619680060 481 LNNPQQLTQIIS-------LFIVQN---KLHKFYDKIPVEVQKL 514
Cdd:cd21340   154 ISDLEELLDLLSswpslreLDLTGNpvcKKPKYRDKIILASKSL 197
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
306-469 1.25e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 115.42  E-value: 1.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 306 ETITAMTNLAIVNCQVYGRNALNLKGFFILNCPDLTPLAF--QLIYLNLSFNDLHYFPTEILCLKNLQILKLRNNPIKEI 383
Cdd:COG4886    72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNltNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 384 PSEIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKL-NLT 462
Cdd:COG4886   152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLE 231


                  ....*..
gi 2619680060 463 KIQFENN 469
Cdd:COG4886   232 TLDLSNN 238
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
343-469 3.14e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 3.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 343 LAFQLIYLNLSFNDLHYFPTEILCLKNLQILKLRNNPikeipsEIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELDVS 422
Cdd:COG4886    71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLS 144

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2619680060 423 YNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKL-NLTKIQFENN 469
Cdd:COG4886   145 NNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLtNLKELDLSNN 192
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
306-515 2.74e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 2.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 306 ETITAMTNLAIVNCqvyGRNALNLKGFFILNCPdltplafQLIYLNLSFNDLHYFPTEILCLKNLQILKLRNNPIKEIPS 385
Cdd:COG4886   153 EPLGNLTNLKSLDL---SNNQLTDLPEELGNLT-------NLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 386 EIQQLEFLRIFTIAFNLITVLPI---------------------GLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTV 444
Cdd:COG4886   223 PLANLTNLETLDLSNNQLTDLPElgnltnleeldlsnnqltdlpPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLL 302

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2619680060 445 DGNELSFFPHGILKLNLTKIQFENNFTHPCFWRDNYLNNPQQLTQIISLFIVQNKLHKFYDKIPVEVQKLL 515
Cdd:COG4886   303 LLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
299-469 5.16e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 5.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 299 TVAATRYETITAMTNLAIVNCQVYGRNALNLKGFFILNCPDLTPLAFQLIYLNLSFNDLHYFPTEILCLKNLQILKLRNN 378
Cdd:COG4886     4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 379 PIKEIPSEIQQLEFLRIFTIAFNLitvlpiGLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILK 458
Cdd:COG4886    84 LLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGN 157

                         170
                  ....*....|..
gi 2619680060 459 L-NLTKIQFENN 469
Cdd:COG4886   158 LtNLKSLDLSNN 169
LRR_8 pfam13855
Leucine rich repeat;
393-449 2.12e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 2.12e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2619680060 393 LRIFTIAFNLITVLPIGLFS-LSYLEELDVSYNELTFI-PNEIQKLRSLEKLTVDGNEL 449
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 373-450 1.95e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.58  E-value: 1.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 373 LKLRNNPIK-EIPSEIQQLEFLRIFTIAFNLIT-VLPIGLFSLSYLEELDVSYNELT-FIPNEIQKLRSLEKLTVDGNEL 449
Cdd:PLN03150  423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502


                  .
gi 2619680060 450 S 450
Cdd:PLN03150  503 S 503
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 345-514 4.99e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 4.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 345 FQLIYLNLSFNDL-HYFPTEILCLKNLQILKLRNNP-IKEIPSEIQQLEFLRIFTIAFN-LITVLPIGLFSLSYLEELDV 421
Cdd:PLN00113  164 SSLKVLDLGGNVLvGKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNnLSGEIPYEIGGLTSLNHLDL 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 422 SYNELTF-IPNEIQKLRSLEKLTVDGNELSF-FPHGILKL-NLTKIQFEnnfthpcfwrDNYLNN--PQQLTQIISLFIV 496
Cdd:PLN00113  244 VYNNLTGpIPSSLGNLKNLQYLFLYQNKLSGpIPPSIFSLqKLISLDLS----------DNSLSGeiPELVIQLQNLEIL 313

                         170
                  ....*....|....*...
gi 2619680060 497 QNKLHKFYDKIPVEVQKL 514
Cdd:PLN00113  314 HLFSNNFTGKIPVALTSL 331
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
301-471 2.92e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.00  E-value: 2.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 301 AATRYETITAMTNlaivnCQVYGRNALNLKGFFILNCPDLTPLafQLIYLNLSFNDLHYFPTEILclKNLQILKLRNNPI 380
Cdd:PRK15370  162 AANREEAVQRMRD-----CLKNNKTELRLKILGLTTIPACIPE--QITTLILDNNELKSLPENLQ--GNIKTLYANSNQL 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 381 KEIPSEIQqlEFLRIFTIAFNLITVLPIGLfsLSYLEELDVSYNELTFIPNEIQKlrSLEKLTVDGNEL----SFFPHGI 456
Cdd:PRK15370  233 TSIPATLP--DTIQEMELSINRITELPERL--PSALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIrtlpAHLPSGI 306

                         170
                  ....*....|....*
gi 2619680060 457 LKLNLtkiqFENNFT 471
Cdd:PRK15370  307 THLNV----QSNSLT 317
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 352-514 1.47e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 1.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 352 LSFNDLH--YFPTEILClKNLQILKLRNNPIKEIP------------------SEIQQLEFLRIFT---IAFNLITVLpI 408
Cdd:cd21340     7 LYLNDKNitKIDNLSLC-KNLKVLYLYDNKITKIEnlefltnlthlylqnnqiEKIENLENLVNLKklyLGGNRISVV-E 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 409 GLFSLSYLEELDVSY------NELTFIPNEIQKL-RSLEKLTVDGNELSfFPHGILKL-NLTKIQFENnfthpcfwrdNY 480
Cdd:cd21340    85 GLENLTNLEELHIENqrlppgEKLTFDPRSLAALsNSLRVLNISGNNID-SLEPLAPLrNLEQLDASN----------NQ 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2619680060 481 LNNPQQLTQIIS-------LFIVQN---KLHKFYDKIPVEVQKL 514
Cdd:cd21340   154 ISDLEELLDLLSswpslreLDLTGNpvcKKPKYRDKIILASKSL 197
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
306-501 2.63e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.77  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 306 ETITAMTNLAIVNCqvyGRNALNlkgffilNCPDLTPLAfQLIYLNLSFNDLHYFPtEILCLKNLQILKLRNNPIKEIPS 385
Cdd:COG4886   222 EPLANLTNLETLDL---SNNQLT-------DLPELGNLT-NLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKL 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 386 EIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKLNLTkIQ 465
Cdd:COG4886   290 KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL-LT 368

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2619680060 466 FENNFTHPCFWRDNYLNNPQQLTQIISLFIVQNKLH 501
Cdd:COG4886   369 LGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLT 404
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 340-449 5.95e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 5.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2619680060 340 LTPLAFQLIYL---NLSFNDLHY-FPTEILCL-KNLQILKLRNNPIK-EIPS-EIQQLEFLRIFTIAFNLITVLPIGLFS 412
Cdd:PLN00113   85 ISSAIFRLPYIqtiNLSNNQLSGpIPDDIFTTsSSLRYLNLSNNNFTgSIPRgSIPNLETLDLSNNMLSGEIPNDIGSFS 164

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2619680060 413 lsYLEELDVSYNELT-FIPNEIQKLRSLEKLTVDGNEL 449
Cdd:PLN00113  165 --SLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQL 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH