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Conserved domains on  [gi|56757647|sp|Q08334|]
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RecName: Full=Interleukin-10 receptor subunit beta; Short=IL-10 receptor subunit beta; Short=IL-10R subunit beta; Short=IL-10RB; AltName: Full=Cytokine receptor class-II member 4; AltName: Full=Cytokine receptor family 2 member 4; Short=CRF2-4; AltName: Full=Interleukin-10 receptor subunit 2; Short=IL-10R subunit 2; Short=IL-10R2; AltName: CD_antigen=CDw210b; Flags: Precursor

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10414172)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 111-213 6.77e-38

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


:

Pssm-ID: 462746  Cd Length: 103  Bit Score: 130.54  E-value: 6.77e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56757647   111 TIIGPPGMQVEVLADSLHMRFLAPKIeNEYETWTMKNVYNSWTYNVQYWKNGTD-EKFQITPQYDFEVLRNLEPWTTYCV 189
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVTVKDPET-REGKNLSLRDLYGSLQYRVSYWKNSSNgEKKNTTSTNSFVVLSDLEPGTTYCV 79

                          90       100
                  ....*....|....*....|....
gi 56757647   190 QVRGFLPDRNKAGEWSEPVCEQTT 213
Cdd:pfam09294  80 SVQAFSPLDNKSSQRSPPQCIRTT 103
Tissue_fac super family cl47630
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 7-100 1.04e-16

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


The actual alignment was detected with superfamily member pfam01108:

Pssm-ID: 460067  Cd Length: 107  Bit Score: 74.73  E-value: 1.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56757647     7 SWLGGCLLVSALGM-----VPPPENVRMNSVNFKNILQWESPAFAKGNLTFTAQYLSYRIFQ----DKCMNTTLTECDFS 77
Cdd:pfam01108   3 TLLLGLLLLALASAaggpsLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYKIYGSGDwknvPNCTNITRTECDLT 82

                          90       100
                  ....*....|....*....|....*
gi 56757647    78 SLSK--YGDHTLRVRAEFADEHSDW 100
Cdd:pfam01108  83 DETSdlTETYYARVRAVSGGGTSSW 107
 
Name Accession Description Interval E-value
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 111-213 6.77e-38

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 130.54  E-value: 6.77e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56757647   111 TIIGPPGMQVEVLADSLHMRFLAPKIeNEYETWTMKNVYNSWTYNVQYWKNGTD-EKFQITPQYDFEVLRNLEPWTTYCV 189
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVTVKDPET-REGKNLSLRDLYGSLQYRVSYWKNSSNgEKKNTTSTNSFVVLSDLEPGTTYCV 79

                          90       100
                  ....*....|....*....|....
gi 56757647   190 QVRGFLPDRNKAGEWSEPVCEQTT 213
Cdd:pfam09294  80 SVQAFSPLDNKSSQRSPPQCIRTT 103
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 7-100 1.04e-16

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 74.73  E-value: 1.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56757647     7 SWLGGCLLVSALGM-----VPPPENVRMNSVNFKNILQWESPAFAKGNLTFTAQYLSYRIFQ----DKCMNTTLTECDFS 77
Cdd:pfam01108   3 TLLLGLLLLALASAaggpsLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYKIYGSGDwknvPNCTNITRTECDLT 82

                          90       100
                  ....*....|....*....|....*
gi 56757647    78 SLSK--YGDHTLRVRAEFADEHSDW 100
Cdd:pfam01108  83 DETSdlTETYYARVRAVSGGGTSSW 107
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 154-212 2.21e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.79  E-value: 2.21e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56757647 154 YNVQYWKNGTDEKFQITPQYDFE---VLRNLEPWTTYCVQVRGFlpDRNKAGEWSEPVCEQT 212
Cdd:cd00063  34 YVVEYREKGSGDWKEVEVTPGSEtsyTLTGLKPGTEYEFRVRAV--NGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 142-203 2.07e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.82  E-value: 2.07e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56757647    142 TWTMKNVYNSWTYNVQYWKNGTD-----EKFQITPQYDFEVLRNLEPWTTYCVQVRGflpdRNKAGE 203
Cdd:smart00060  20 SWEPPPDDGITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRA----VNGAGE 82
 
Name Accession Description Interval E-value
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 111-213 6.77e-38

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 130.54  E-value: 6.77e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56757647   111 TIIGPPGMQVEVLADSLHMRFLAPKIeNEYETWTMKNVYNSWTYNVQYWKNGTD-EKFQITPQYDFEVLRNLEPWTTYCV 189
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVTVKDPET-REGKNLSLRDLYGSLQYRVSYWKNSSNgEKKNTTSTNSFVVLSDLEPGTTYCV 79

                          90       100
                  ....*....|....*....|....
gi 56757647   190 QVRGFLPDRNKAGEWSEPVCEQTT 213
Cdd:pfam09294  80 SVQAFSPLDNKSSQRSPPQCIRTT 103
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 7-100 1.04e-16

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 74.73  E-value: 1.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56757647     7 SWLGGCLLVSALGM-----VPPPENVRMNSVNFKNILQWESPAFAKGNLTFTAQYLSYRIFQ----DKCMNTTLTECDFS 77
Cdd:pfam01108   3 TLLLGLLLLALASAaggpsLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYKIYGSGDwknvPNCTNITRTECDLT 82

                          90       100
                  ....*....|....*....|....*
gi 56757647    78 SLSK--YGDHTLRVRAEFADEHSDW 100
Cdd:pfam01108  83 DETSdlTETYYARVRAVSGGGTSSW 107
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 154-212 2.21e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.79  E-value: 2.21e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56757647 154 YNVQYWKNGTDEKFQITPQYDFE---VLRNLEPWTTYCVQVRGFlpDRNKAGEWSEPVCEQT 212
Cdd:cd00063  34 YVVEYREKGSGDWKEVEVTPGSEtsyTLTGLKPGTEYEFRVRAV--NGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 142-203 2.07e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.82  E-value: 2.07e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56757647    142 TWTMKNVYNSWTYNVQYWKNGTD-----EKFQITPQYDFEVLRNLEPWTTYCVQVRGflpdRNKAGE 203
Cdd:smart00060  20 SWEPPPDDGITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRA----VNGAGE 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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