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Conserved domains on  [gi|121939987|sp|Q08AF3|]
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RecName: Full=Schlafen family member 5

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PHA02782 super family cl31504
hypothetical protein; Provisional
34-332 2.85e-37

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PHA02782:

Pssm-ID: 165147 [Multi-domain]  Cd Length: 503  Bit Score: 147.12  E-value: 2.85e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121939987  34 RLREKQNEIILRAVCALLNSGGGIIKAEIENKGYNY---ERHGVGLDVPPIFRSHLDKMQKENHFLIFVKSWNTEAgvPL 110
Cdd:PHA02782 200 KLGENDTENLSTSISALLNSGGGTIEVTSKEERVDYvlmKRLESIRHLWSVVYDHFNVVNGKERCYIHMHSSNQSP--MP 277
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121939987 111 ATLCSNLYHRERTSTDVMDSQEALAFLkcrtqtpTNINVSNSLGPQAAQGSVQY------EGNINVSAAALFDRKRLQYL 184
Cdd:PHA02782 278 STVKTNLYMKTMGSCLQMDSMEALEYL-------SELKESGGRSPRPELPEFEYpdgvedTGSIERLAEEFFNRSELQAG 350
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121939987 185 EKLNLPESTHVEFVMFST-DVSHCVKDRLPKCVSAFANTEGGYVFFGVHDETCQVIGCEKEKIDLTSLRASIDGCIKKLP 263
Cdd:PHA02782 351 ESVKFGNSINVKHTSVSAkQLRTRIRQQLPSILSSFANTEGGYLFIGVDNNTHKVIGFTVGQDYLKLVENDIEKYIKRLR 430
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 121939987 264 VHHFCTQRPEIKYVLNFLEVHDKG--ALRGYVCAIKVEKFCCAVFAKVPSSWQVKDNRVRQLPTREWTAWM 332
Cdd:PHA02782 431 VVHFCEKKEDIKYACRFIKVYKPGeeTTSTYVCAIKVERCCCAVFADWPESWYMDTSGIKKYSPDEWVSHI 501
UvrD_C_2 super family cl38418
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ...
839-887 4.10e-04

UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.


The actual alignment was detected with superfamily member pfam13538:

Pssm-ID: 463913 [Multi-domain]  Cd Length: 52  Bit Score: 39.09  E-value: 4.10e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 121939987  839 HIVLDSVCRFSGLERNIVFGINPGVAPPAGA---YNLLLCLASRAKRHLYIL 887
Cdd:pfam13538   1 LAYALTVHKAQGSEFPAVFLVDPDLTAHYHSmlrRRLLYTAVTRARKKLVLV 52
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
574-657 2.05e-03

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member pfam13401:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 129  Bit Score: 39.25  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121939987  574 LFVHGLPGSGKTILALRIMEKirnvFHCEPANILYICENQPlkklvsFSKKNICQPVTRKTFMKNN--------FEHIQH 645
Cdd:pfam13401   8 LVLTGESGTGKTTLLRRLLEQ----LPEVRDSVVFVDLPSG------TSPKDLLRALLRALGLPLSgrlskeelLAALQQ 77
                          90       100
                  ....*....|....*....|..
gi 121939987  646 ----------IIIDDAQNFRTE 657
Cdd:pfam13401  78 lllalavavvLIIDEAQHLSLE 99
 
Name Accession Description Interval E-value
PHA02782 PHA02782
hypothetical protein; Provisional
34-332 2.85e-37

hypothetical protein; Provisional


Pssm-ID: 165147 [Multi-domain]  Cd Length: 503  Bit Score: 147.12  E-value: 2.85e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121939987  34 RLREKQNEIILRAVCALLNSGGGIIKAEIENKGYNY---ERHGVGLDVPPIFRSHLDKMQKENHFLIFVKSWNTEAgvPL 110
Cdd:PHA02782 200 KLGENDTENLSTSISALLNSGGGTIEVTSKEERVDYvlmKRLESIRHLWSVVYDHFNVVNGKERCYIHMHSSNQSP--MP 277
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121939987 111 ATLCSNLYHRERTSTDVMDSQEALAFLkcrtqtpTNINVSNSLGPQAAQGSVQY------EGNINVSAAALFDRKRLQYL 184
Cdd:PHA02782 278 STVKTNLYMKTMGSCLQMDSMEALEYL-------SELKESGGRSPRPELPEFEYpdgvedTGSIERLAEEFFNRSELQAG 350
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121939987 185 EKLNLPESTHVEFVMFST-DVSHCVKDRLPKCVSAFANTEGGYVFFGVHDETCQVIGCEKEKIDLTSLRASIDGCIKKLP 263
Cdd:PHA02782 351 ESVKFGNSINVKHTSVSAkQLRTRIRQQLPSILSSFANTEGGYLFIGVDNNTHKVIGFTVGQDYLKLVENDIEKYIKRLR 430
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 121939987 264 VHHFCTQRPEIKYVLNFLEVHDKG--ALRGYVCAIKVEKFCCAVFAKVPSSWQVKDNRVRQLPTREWTAWM 332
Cdd:PHA02782 431 VVHFCEKKEDIKYACRFIKVYKPGeeTTSTYVCAIKVERCCCAVFADWPESWYMDTSGIKKYSPDEWVSHI 501
AlbA_2 pfam04326
Putative DNA-binding domain; This family belongs to the AlbA clan of DNA-binding domains.
191-308 1.33e-13

Putative DNA-binding domain; This family belongs to the AlbA clan of DNA-binding domains.


Pssm-ID: 461263  Cd Length: 116  Bit Score: 68.10  E-value: 1.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121939987  191 ESTHVEFvmfSTDVSHCVKDRLPKCVSAFANTEGGYVFFGVHDeTCQVIGCEKEKIDLTSlrasidgcIKKLPVHHFCTQ 270
Cdd:pfam04326   1 ESETLEF---KESLGKSSKKKIAKTISAFANTEGGTIVIGVDD-TGKIVGVSDDEKDTED--------LLKNQILDLIKP 68
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 121939987  271 RPEIKYVlnFLEVHDKgalrgYVCAIKVEKFCCAVFAK 308
Cdd:pfam04326  69 PIEVDIE--EIEIDGK-----YVLVVEIPEGKLKPYYT 99
COG2865 COG2865
Predicted transcriptional regulator, contains HTH domain [Transcription];
182-300 2.43e-11

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 442112  Cd Length: 123  Bit Score: 61.83  E-value: 2.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121939987 182 QYLEKL-NLPESTHVEFVMFSTDVSHCVKDrlpkcVSAFANTEGGYVFFGVHDETcQVIGCEKEKIDLTSLRASIDGCIK 260
Cdd:COG2865    1 EELKELlAGGESETLEFKESLNEPDEILKT-----VCAFANTEGGTLLIGVDDDG-EIVGLDDPDKLLERLENLIADNIS 74
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 121939987 261 klpvhhfctqrPEIKYVLNFLEVHDKgalrgYVCAIKVEK 300
Cdd:COG2865   75 -----------PPIRPDVEEVEIDGK-----RVLVIEVPP 98
UvrD_C_2 pfam13538
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ...
839-887 4.10e-04

UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.


Pssm-ID: 463913 [Multi-domain]  Cd Length: 52  Bit Score: 39.09  E-value: 4.10e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 121939987  839 HIVLDSVCRFSGLERNIVFGINPGVAPPAGA---YNLLLCLASRAKRHLYIL 887
Cdd:pfam13538   1 LAYALTVHKAQGSEFPAVFLVDPDLTAHYHSmlrRRLLYTAVTRARKKLVLV 52
AAA_22 pfam13401
AAA domain;
574-657 2.05e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 39.25  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121939987  574 LFVHGLPGSGKTILALRIMEKirnvFHCEPANILYICENQPlkklvsFSKKNICQPVTRKTFMKNN--------FEHIQH 645
Cdd:pfam13401   8 LVLTGESGTGKTTLLRRLLEQ----LPEVRDSVVFVDLPSG------TSPKDLLRALLRALGLPLSgrlskeelLAALQQ 77
                          90       100
                  ....*....|....*....|..
gi 121939987  646 ----------IIIDDAQNFRTE 657
Cdd:pfam13401  78 lllalavavvLIIDEAQHLSLE 99
 
Name Accession Description Interval E-value
PHA02782 PHA02782
hypothetical protein; Provisional
34-332 2.85e-37

hypothetical protein; Provisional


Pssm-ID: 165147 [Multi-domain]  Cd Length: 503  Bit Score: 147.12  E-value: 2.85e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121939987  34 RLREKQNEIILRAVCALLNSGGGIIKAEIENKGYNY---ERHGVGLDVPPIFRSHLDKMQKENHFLIFVKSWNTEAgvPL 110
Cdd:PHA02782 200 KLGENDTENLSTSISALLNSGGGTIEVTSKEERVDYvlmKRLESIRHLWSVVYDHFNVVNGKERCYIHMHSSNQSP--MP 277
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121939987 111 ATLCSNLYHRERTSTDVMDSQEALAFLkcrtqtpTNINVSNSLGPQAAQGSVQY------EGNINVSAAALFDRKRLQYL 184
Cdd:PHA02782 278 STVKTNLYMKTMGSCLQMDSMEALEYL-------SELKESGGRSPRPELPEFEYpdgvedTGSIERLAEEFFNRSELQAG 350
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121939987 185 EKLNLPESTHVEFVMFST-DVSHCVKDRLPKCVSAFANTEGGYVFFGVHDETCQVIGCEKEKIDLTSLRASIDGCIKKLP 263
Cdd:PHA02782 351 ESVKFGNSINVKHTSVSAkQLRTRIRQQLPSILSSFANTEGGYLFIGVDNNTHKVIGFTVGQDYLKLVENDIEKYIKRLR 430
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 121939987 264 VHHFCTQRPEIKYVLNFLEVHDKG--ALRGYVCAIKVEKFCCAVFAKVPSSWQVKDNRVRQLPTREWTAWM 332
Cdd:PHA02782 431 VVHFCEKKEDIKYACRFIKVYKPGeeTTSTYVCAIKVERCCCAVFADWPESWYMDTSGIKKYSPDEWVSHI 501
AlbA_2 pfam04326
Putative DNA-binding domain; This family belongs to the AlbA clan of DNA-binding domains.
191-308 1.33e-13

Putative DNA-binding domain; This family belongs to the AlbA clan of DNA-binding domains.


Pssm-ID: 461263  Cd Length: 116  Bit Score: 68.10  E-value: 1.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121939987  191 ESTHVEFvmfSTDVSHCVKDRLPKCVSAFANTEGGYVFFGVHDeTCQVIGCEKEKIDLTSlrasidgcIKKLPVHHFCTQ 270
Cdd:pfam04326   1 ESETLEF---KESLGKSSKKKIAKTISAFANTEGGTIVIGVDD-TGKIVGVSDDEKDTED--------LLKNQILDLIKP 68
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 121939987  271 RPEIKYVlnFLEVHDKgalrgYVCAIKVEKFCCAVFAK 308
Cdd:pfam04326  69 PIEVDIE--EIEIDGK-----YVLVVEIPEGKLKPYYT 99
COG2865 COG2865
Predicted transcriptional regulator, contains HTH domain [Transcription];
182-300 2.43e-11

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 442112  Cd Length: 123  Bit Score: 61.83  E-value: 2.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121939987 182 QYLEKL-NLPESTHVEFVMFSTDVSHCVKDrlpkcVSAFANTEGGYVFFGVHDETcQVIGCEKEKIDLTSLRASIDGCIK 260
Cdd:COG2865    1 EELKELlAGGESETLEFKESLNEPDEILKT-----VCAFANTEGGTLLIGVDDDG-EIVGLDDPDKLLERLENLIADNIS 74
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 121939987 261 klpvhhfctqrPEIKYVLNFLEVHDKgalrgYVCAIKVEK 300
Cdd:COG2865   75 -----------PPIRPDVEEVEIDGK-----RVLVIEVPP 98
UvrD_C_2 pfam13538
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ...
839-887 4.10e-04

UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.


Pssm-ID: 463913 [Multi-domain]  Cd Length: 52  Bit Score: 39.09  E-value: 4.10e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 121939987  839 HIVLDSVCRFSGLERNIVFGINPGVAPPAGA---YNLLLCLASRAKRHLYIL 887
Cdd:pfam13538   1 LAYALTVHKAQGSEFPAVFLVDPDLTAHYHSmlrRRLLYTAVTRARKKLVLV 52
AAA_22 pfam13401
AAA domain;
574-657 2.05e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 39.25  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121939987  574 LFVHGLPGSGKTILALRIMEKirnvFHCEPANILYICENQPlkklvsFSKKNICQPVTRKTFMKNN--------FEHIQH 645
Cdd:pfam13401   8 LVLTGESGTGKTTLLRRLLEQ----LPEVRDSVVFVDLPSG------TSPKDLLRALLRALGLPLSgrlskeelLAALQQ 77
                          90       100
                  ....*....|....*....|..
gi 121939987  646 ----------IIIDDAQNFRTE 657
Cdd:pfam13401  78 lllalavavvLIIDEAQHLSLE 99
DUF2075 pfam09848
Schlafen group 3, DNA/RNA helicase domain; This domain is found in at the C terminus of group ...
574-695 5.18e-03

Schlafen group 3, DNA/RNA helicase domain; This domain is found in at the C terminus of group 3 Schlafen proteins from mammals, and represents the DNA/RNA helicase domain. Schlafen proteins are involved in the control of cell proliferation, induction of immune responses, and in the regulation of viral replication. These proteins inhibit DNA replication and promote cell death in response to DNA damage. They play a role in genome surveillance to kill cells with defective replication. This domain is also found in various uncharacterized prokaryotic proteins fused to a DNA helicase, GIY-YIG or PD-(D/E)XK catalytic domain or HsdR-N(terminal) domain, which are similar to AAA DNA helicase, Type III restriction enzyme ATPase, RecD and RuvB helicase.


Pssm-ID: 430875 [Multi-domain]  Cd Length: 355  Bit Score: 39.96  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121939987  574 LFVHGLPGSGKTILALRIMEKIRNVFHCEPANILYIceNQPL-----KKLV-SFSKKNICQPVTR-KTFMknNFEHIQH- 645
Cdd:pfam09848   4 FLVTGGPGTGKTVIGLNLFAELEDSDLGRTAVYLSG--NHPLvlvlyEALAgDLRKKRKKSAFQRpTSFI--NNLHKTHp 79
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 121939987  646 ----IIIDDAQ---NFRTEDGDWYGKAKFITQTARdgPGVLWIFLDYFQTYHLSCSG 695
Cdd:pfam09848  80 hedvVIFDEAHrlwDKSDPYNNFSGPNQLKEIMKR--AKVIVFLVDEGQVLNTGEYG 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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