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Conserved domains on  [gi|75221088|sp|Q40960|]
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RecName: Full=Pollen allergen Phl p 5.0101; AltName: Full=Allergen Phl p 5a; AltName: Full=Allergen Phl p V; AltName: Allergen=Phl p 5.0101; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Allergen_V_VI super family cl03283
Group V, VI major allergens from grass, including Phlp 5, Phlp 6, Pha a 5 and Lol p 5; This ...
 7-174 4.56e-35

Group V, VI major allergens from grass, including Phlp 5, Phlp 6, Pha a 5 and Lol p 5; This family contains major allergens from various grass pollen, including Phl p 5 and Phl p 6 (timothy grass), Lol p 5 (rye grass) and Pha a 5 (canary grass). They induce allergic rhinitis and bronchial asthma in millions of allergic patients worldwide. These group V and group VI grass-pollen allergens belong to a new class of protease-resistant four-helix-bundle domains, which also have internal helix-turn-helix homology pointing to a special type of four-helix bundle topology, defined as twinned two-helix bundle. IgE binding experiments with recombinant Phl p 6 fragments indicated that the N terminus of the allergen is required for IgE recognition. Immunotherapy treatment for these allergies generally involves administration of grass pollen extracts which induce an initial rise in specific immunoglobulin E (sIgE) production followed by a progressive decline during the treatment.


The actual alignment was detected with superfamily member pfam01620:

Pssm-ID: 470774  Cd Length: 155  Bit Score: 124.62  E-value: 4.56e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75221088     7 TVALFLAVALVAGPAASYAadlgygpatpaapaaGYTPATPAAPAEAAPAGKATTEEQKLIEKINAGFKAALAAAAGVQP 86
Cdd:pfam01620   1 TVALFLAVALVAGPAVSYA---------------AYAPGAPATPAAPGTQPKATTPEQKLMEDINNGFKAAVAAAAGVPA 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75221088    87 ADKYRTFVATFGAASNKAFAEGLSGEPKG--AAESSSKAALTSKLDAAYKLAYKTAEGATPEAKYDAYVATLSEALRIIA 164
Cdd:pfam01620  66 ADKYKTFEATFSAASNKAFAEVLKGAATGqyAAQSSSMAKLSSSLELSYKLAYDKAQGATPETKYDAYVATLTESLRVIS 145

                         170
                  ....*....|
gi 75221088   165 GTLEVHAVKP 174
Cdd:pfam01620 146 GTLEVHSVKP 155
Allergen_V_VI super family cl03283
Group V, VI major allergens from grass, including Phlp 5, Phlp 6, Pha a 5 and Lol p 5; This ...
 236-280 3.06e-06

Group V, VI major allergens from grass, including Phlp 5, Phlp 6, Pha a 5 and Lol p 5; This family contains major allergens from various grass pollen, including Phl p 5 and Phl p 6 (timothy grass), Lol p 5 (rye grass) and Pha a 5 (canary grass). They induce allergic rhinitis and bronchial asthma in millions of allergic patients worldwide. These group V and group VI grass-pollen allergens belong to a new class of protease-resistant four-helix-bundle domains, which also have internal helix-turn-helix homology pointing to a special type of four-helix bundle topology, defined as twinned two-helix bundle. IgE binding experiments with recombinant Phl p 6 fragments indicated that the N terminus of the allergen is required for IgE recognition. Immunotherapy treatment for these allergies generally involves administration of grass pollen extracts which induce an initial rise in specific immunoglobulin E (sIgE) production followed by a progressive decline during the treatment.


The actual alignment was detected with superfamily member cd12805:

Pssm-ID: 470774  Cd Length: 85  Bit Score: 44.79  E-value: 3.06e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 75221088 236 KFIPALEAAVKQAYAATVATAPEVKYTVFETALKKAITAMSEAQK 280
Cdd:cd12805   1 KLIEKINAAFKQAYAAAAAAAPADKYKVFEAAFKKAITAASAAAK 45
 
Name Accession Description Interval E-value
Pollen_allerg_2 pfam01620
Ribonuclease (pollen allergen); This family contains grass pollen proteins of group V. Swiss: ...
 7-174 4.56e-35

Ribonuclease (pollen allergen); This family contains grass pollen proteins of group V. Swiss:Q40963 has been shown to possess ribonuclease activity.


Pssm-ID: 460269  Cd Length: 155  Bit Score: 124.62  E-value: 4.56e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75221088     7 TVALFLAVALVAGPAASYAadlgygpatpaapaaGYTPATPAAPAEAAPAGKATTEEQKLIEKINAGFKAALAAAAGVQP 86
Cdd:pfam01620   1 TVALFLAVALVAGPAVSYA---------------AYAPGAPATPAAPGTQPKATTPEQKLMEDINNGFKAAVAAAAGVPA 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75221088    87 ADKYRTFVATFGAASNKAFAEGLSGEPKG--AAESSSKAALTSKLDAAYKLAYKTAEGATPEAKYDAYVATLSEALRIIA 164
Cdd:pfam01620  66 ADKYKTFEATFSAASNKAFAEVLKGAATGqyAAQSSSMAKLSSSLELSYKLAYDKAQGATPETKYDAYVATLTESLRVIS 145

                         170
                  ....*....|
gi 75221088   165 GTLEVHAVKP 174
Cdd:pfam01620 146 GTLEVHSVKP 155
Allergen_V_VI cd12805
Group V, VI major allergens from grass, including Phlp 5, Phlp 6, Pha a 5 and Lol p 5; This ...
 65-164 1.85e-09

Group V, VI major allergens from grass, including Phlp 5, Phlp 6, Pha a 5 and Lol p 5; This family contains major allergens from various grass pollen, including Phl p 5 and Phl p 6 (timothy grass), Lol p 5 (rye grass) and Pha a 5 (canary grass). They induce allergic rhinitis and bronchial asthma in millions of allergic patients worldwide. These group V and group VI grass-pollen allergens belong to a new class of protease-resistant four-helix-bundle domains, which also have internal helix-turn-helix homology pointing to a special type of four-helix bundle topology, defined as twinned two-helix bundle. IgE binding experiments with recombinant Phl p 6 fragments indicated that the N terminus of the allergen is required for IgE recognition. Immunotherapy treatment for these allergies generally involves administration of grass pollen extracts which induce an initial rise in specific immunoglobulin E (sIgE) production followed by a progressive decline during the treatment.


Pssm-ID: 214004  Cd Length: 85  Bit Score: 53.64  E-value: 1.85e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75221088  65 KLIEKINAGFKAALAAAAGVQPADKYRTFVATFGAASNKAFAEglsgepkgaaessskAALTSKLDAAYKLAYKTAEGAT 144
Cdd:cd12805   1 KLIEKINAAFKQAYAAAAAAAPADKYKVFEAAFKKAITAASAA---------------AKVAKKLDAAYKAAYDAAAAAT 65

                        90       100
                ....*....|....*....|
gi 75221088 145 PEAKYDAYVATLSEALRIIA 164
Cdd:cd12805  66 PEAKYDAFVAALSEALRIAA 85
Allergen_V_VI cd12805
Group V, VI major allergens from grass, including Phlp 5, Phlp 6, Pha a 5 and Lol p 5; This ...
 236-280 3.06e-06

Group V, VI major allergens from grass, including Phlp 5, Phlp 6, Pha a 5 and Lol p 5; This family contains major allergens from various grass pollen, including Phl p 5 and Phl p 6 (timothy grass), Lol p 5 (rye grass) and Pha a 5 (canary grass). They induce allergic rhinitis and bronchial asthma in millions of allergic patients worldwide. These group V and group VI grass-pollen allergens belong to a new class of protease-resistant four-helix-bundle domains, which also have internal helix-turn-helix homology pointing to a special type of four-helix bundle topology, defined as twinned two-helix bundle. IgE binding experiments with recombinant Phl p 6 fragments indicated that the N terminus of the allergen is required for IgE recognition. Immunotherapy treatment for these allergies generally involves administration of grass pollen extracts which induce an initial rise in specific immunoglobulin E (sIgE) production followed by a progressive decline during the treatment.


Pssm-ID: 214004  Cd Length: 85  Bit Score: 44.79  E-value: 3.06e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 75221088 236 KFIPALEAAVKQAYAATVATAPEVKYTVFETALKKAITAMSEAQK 280
Cdd:cd12805   1 KLIEKINAAFKQAYAAAAAAAPADKYKVFEAAFKKAITAASAAAK 45
 
Name Accession Description Interval E-value
Pollen_allerg_2 pfam01620
Ribonuclease (pollen allergen); This family contains grass pollen proteins of group V. Swiss: ...
 7-174 4.56e-35

Ribonuclease (pollen allergen); This family contains grass pollen proteins of group V. Swiss:Q40963 has been shown to possess ribonuclease activity.


Pssm-ID: 460269  Cd Length: 155  Bit Score: 124.62  E-value: 4.56e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75221088     7 TVALFLAVALVAGPAASYAadlgygpatpaapaaGYTPATPAAPAEAAPAGKATTEEQKLIEKINAGFKAALAAAAGVQP 86
Cdd:pfam01620   1 TVALFLAVALVAGPAVSYA---------------AYAPGAPATPAAPGTQPKATTPEQKLMEDINNGFKAAVAAAAGVPA 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75221088    87 ADKYRTFVATFGAASNKAFAEGLSGEPKG--AAESSSKAALTSKLDAAYKLAYKTAEGATPEAKYDAYVATLSEALRIIA 164
Cdd:pfam01620  66 ADKYKTFEATFSAASNKAFAEVLKGAATGqyAAQSSSMAKLSSSLELSYKLAYDKAQGATPETKYDAYVATLTESLRVIS 145

                         170
                  ....*....|
gi 75221088   165 GTLEVHAVKP 174
Cdd:pfam01620 146 GTLEVHSVKP 155
Allergen_V_VI cd12805
Group V, VI major allergens from grass, including Phlp 5, Phlp 6, Pha a 5 and Lol p 5; This ...
 65-164 1.85e-09

Group V, VI major allergens from grass, including Phlp 5, Phlp 6, Pha a 5 and Lol p 5; This family contains major allergens from various grass pollen, including Phl p 5 and Phl p 6 (timothy grass), Lol p 5 (rye grass) and Pha a 5 (canary grass). They induce allergic rhinitis and bronchial asthma in millions of allergic patients worldwide. These group V and group VI grass-pollen allergens belong to a new class of protease-resistant four-helix-bundle domains, which also have internal helix-turn-helix homology pointing to a special type of four-helix bundle topology, defined as twinned two-helix bundle. IgE binding experiments with recombinant Phl p 6 fragments indicated that the N terminus of the allergen is required for IgE recognition. Immunotherapy treatment for these allergies generally involves administration of grass pollen extracts which induce an initial rise in specific immunoglobulin E (sIgE) production followed by a progressive decline during the treatment.


Pssm-ID: 214004  Cd Length: 85  Bit Score: 53.64  E-value: 1.85e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75221088  65 KLIEKINAGFKAALAAAAGVQPADKYRTFVATFGAASNKAFAEglsgepkgaaessskAALTSKLDAAYKLAYKTAEGAT 144
Cdd:cd12805   1 KLIEKINAAFKQAYAAAAAAAPADKYKVFEAAFKKAITAASAA---------------AKVAKKLDAAYKAAYDAAAAAT 65

                        90       100
                ....*....|....*....|
gi 75221088 145 PEAKYDAYVATLSEALRIIA 164
Cdd:cd12805  66 PEAKYDAFVAALSEALRIAA 85
Allergen_V_VI cd12805
Group V, VI major allergens from grass, including Phlp 5, Phlp 6, Pha a 5 and Lol p 5; This ...
 236-280 3.06e-06

Group V, VI major allergens from grass, including Phlp 5, Phlp 6, Pha a 5 and Lol p 5; This family contains major allergens from various grass pollen, including Phl p 5 and Phl p 6 (timothy grass), Lol p 5 (rye grass) and Pha a 5 (canary grass). They induce allergic rhinitis and bronchial asthma in millions of allergic patients worldwide. These group V and group VI grass-pollen allergens belong to a new class of protease-resistant four-helix-bundle domains, which also have internal helix-turn-helix homology pointing to a special type of four-helix bundle topology, defined as twinned two-helix bundle. IgE binding experiments with recombinant Phl p 6 fragments indicated that the N terminus of the allergen is required for IgE recognition. Immunotherapy treatment for these allergies generally involves administration of grass pollen extracts which induce an initial rise in specific immunoglobulin E (sIgE) production followed by a progressive decline during the treatment.


Pssm-ID: 214004  Cd Length: 85  Bit Score: 44.79  E-value: 3.06e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 75221088 236 KFIPALEAAVKQAYAATVATAPEVKYTVFETALKKAITAMSEAQK 280
Cdd:cd12805   1 KLIEKINAAFKQAYAAAAAAAPADKYKVFEAAFKKAITAASAAAK 45
Allergen_V_VI cd12805
Group V, VI major allergens from grass, including Phlp 5, Phlp 6, Pha a 5 and Lol p 5; This ...
 188-276 5.44e-04

Group V, VI major allergens from grass, including Phlp 5, Phlp 6, Pha a 5 and Lol p 5; This family contains major allergens from various grass pollen, including Phl p 5 and Phl p 6 (timothy grass), Lol p 5 (rye grass) and Pha a 5 (canary grass). They induce allergic rhinitis and bronchial asthma in millions of allergic patients worldwide. These group V and group VI grass-pollen allergens belong to a new class of protease-resistant four-helix-bundle domains, which also have internal helix-turn-helix homology pointing to a special type of four-helix bundle topology, defined as twinned two-helix bundle. IgE binding experiments with recombinant Phl p 6 fragments indicated that the N terminus of the allergen is required for IgE recognition. Immunotherapy treatment for these allergies generally involves administration of grass pollen extracts which induce an initial rise in specific immunoglobulin E (sIgE) production followed by a progressive decline during the treatment.


Pssm-ID: 214004  Cd Length: 85  Bit Score: 38.24  E-value: 5.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75221088 188 QVIEKVDAAFKVAATAANAAPANDKFTVFEAAFNDAIKASTGGAyesyKFIPALEAAVKQAYAATVATAPEVKYTVFETA 267
Cdd:cd12805   1 KLIEKINAAFKQAYAAAAAAAPADKYKVFEAAFKKAITAASAAA----KVAKKLDAAYKAAYDAAAAATPEAKYDAFVAA 76


                ....*....
gi 75221088 268 LKKAITAMS 276
Cdd:cd12805  77 LSEALRIAA 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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