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Conserved domains on  [gi|2497544|sp|Q57572|]
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RecName: Full=Pyruvate kinase; Short=PK

Protein Classification

pyruvate kinase( domain architecture ID 1562468)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

CATH:  2.40.33.10|3.20.20.60|3.40.1380.20
EC:  2.7.1.40
Gene Ontology:  GO:0004743|GO:0006096|GO:0005524|GO:0030955|GO:0000287
PubMed:  31342570
SCOP:  4003255|4002474|4000500

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pyruvate_Kinase super family cl39076
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 6-444 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


The actual alignment was detected with superfamily member TIGR01064:

Pssm-ID: 453956 [Multi-domain]  Cd Length: 472  Bit Score: 540.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544      6 RKTKILVTLGPSLENK--LDKAINL-IDGVRFNMSHATTDYCEKFLNILEK------NNIAKVMDLKGIKIRIKEVKLKN 76
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPemLKKLLDAgMNVARLNFSHGSHEEHGKRIENVREaaeklgRPVAILLDTKGPEIRTGEIKGGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544     77 KILKMGEKVVIG----------EDIKLNYN--IDTIEEGHFILINDGKIKLRVVEKT-DKIIAVVEVGGEIKEGMGVNLP 143
Cdd:TIGR01064  81 VKLKKGDKVIITtddikgegdeEKVYVDYKglTKDVVEGDKILVDDGKISLVVVSVEgDKVICEVLNGGTLKSKKGVNLP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    144 DTRIELPIIDETDLKNIKFAVEKDFEYIALSFVRNKEDVKELKDIISEYK-GDCEVISKIETKEGLKNIKEIARESDGVM 222
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNIDEIAEASDGIM 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    223 VARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETTIGKYP 302
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    303 IEAIKVLNKVAKVADE---HYEEFGDR--VCLEVESIDEGLVYAVYELYKKLNTKLVITPTYSGRTAKLISKLRINSKII 377
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKalaYLTNFNDRknSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2497544    378 APTPNIRTLKRLRLVWGVESCLMEEFDDM-----EKIINTCREMAKKEIGKGIYLITLGHPIGQKKTNTIKV 444
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPFLVDEEPSDtdarvNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
 
Name Accession Description Interval E-value
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 6-444 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 540.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544      6 RKTKILVTLGPSLENK--LDKAINL-IDGVRFNMSHATTDYCEKFLNILEK------NNIAKVMDLKGIKIRIKEVKLKN 76
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPemLKKLLDAgMNVARLNFSHGSHEEHGKRIENVREaaeklgRPVAILLDTKGPEIRTGEIKGGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544     77 KILKMGEKVVIG----------EDIKLNYN--IDTIEEGHFILINDGKIKLRVVEKT-DKIIAVVEVGGEIKEGMGVNLP 143
Cdd:TIGR01064  81 VKLKKGDKVIITtddikgegdeEKVYVDYKglTKDVVEGDKILVDDGKISLVVVSVEgDKVICEVLNGGTLKSKKGVNLP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    144 DTRIELPIIDETDLKNIKFAVEKDFEYIALSFVRNKEDVKELKDIISEYK-GDCEVISKIETKEGLKNIKEIARESDGVM 222
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNIDEIAEASDGIM 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    223 VARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETTIGKYP 302
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    303 IEAIKVLNKVAKVADE---HYEEFGDR--VCLEVESIDEGLVYAVYELYKKLNTKLVITPTYSGRTAKLISKLRINSKII 377
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKalaYLTNFNDRknSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2497544    378 APTPNIRTLKRLRLVWGVESCLMEEFDDM-----EKIINTCREMAKKEIGKGIYLITLGHPIGQKKTNTIKV 444
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPFLVDEEPSDtdarvNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 4-447 1.19e-175

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 499.95  E-value: 1.19e-175
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    4 MMRKTKILVTLGPSLEN--KLDKAINL-IDGVRFNMSHATTDYCEKFLNIL-----EKN-NIAKVMDLKGIKIRIKEVKl 74
Cdd:COG0469   1 MMRRTKIVATLGPASDSpeVLRKLIEAgMDVARLNFSHGDHEEHRERIELIreaakELGrPVAILLDLQGPKIRTGKFK- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   75 KNKI-LKMGEKVVI--------GEDIKLNYN--IDTIEEGHFILINDGKIKLRVVEKT-DKIIAVVEVGGEIKEGMGVNL 142
Cdd:COG0469  80 EGPVeLKKGDTFTLttddvegdAERVSVTYPelPEDVKPGDRILLDDGKIELRVEEVEgDEVVCEVVNGGVLSSRKGVNL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544  143 PDTRIELPIIDETDLKNIKFAVEKDFEYIALSFVRNKEDVKELKDIISEYKGDCEVISKIETKEGLKNIKEIARESDGVM 222
Cdd:COG0469 160 PGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIM 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544  223 VARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETTIGKYP 302
Cdd:COG0469 240 VARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYP 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544  303 IEAIKVLNKVAKVADEHYEEFGD---RVCLEVESIDEGLVYAVYELYKKLNTKLVITPTYSGRTAKLISKLRINSKIIAP 379
Cdd:COG0469 320 VEAVETMARIAEEAEKSLDYRRIldrLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILAL 399

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2497544  380 TPNIRTLKRLRLVWGVESCLMEEFDDMEKIINTCREMAKKE--IGKG-IYLITLGHPIGQK-KTNTIKVESI 447
Cdd:COG0469 400 TPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEglVKPGdLVVITAGVPVGVPgTTNTLKVHRV 471
PRK05826 PRK05826
pyruvate kinase; Provisional
 4-436 1.61e-136

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 400.30  E-value: 1.61e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544     4 MMRKTKILVTLGPSLENK--LDKAINL-IDGVRFNMSHATTDYCEKFLNIL----EKNN--IAKVMDLKGIKIRIKEVKL 74
Cdd:PRK05826   2 MLRRTKIVATLGPASDSPenLEKLIEAgVNVVRLNFSHGSHEEHGKRAALVreiaAKLGrpVAILLDLKGPKIRVGKFKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    75 KNKILKMGEKVVIG---------EDIKLNYN--IDTIEEGHFILINDGKIKLRVVEKT-DKIIAVVEVGGEIKEGMGVNL 142
Cdd:PRK05826  82 GKITLKTGDKFTLDtdqkeegdkERVGVDYKglPKDVKPGDILLLDDGKLQLKVVEVDgDEVETEVKNGGPLSNNKGINI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   143 PDTRIELPIIDETDLKNIKFAVEKDFEYIALSFVRNKEDVKELKDIISEYKG-DCEVISKIETKEGLKNIKEIARESDGV 221
Cdd:PRK05826 162 PGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCpHAKIIAKIERAEAVDNIDEIIEASDGI 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   222 MVARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETTIGKY 301
Cdd:PRK05826 242 MVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKY 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   302 PIEAIKVLNKVAKVADEHYEEFGDRVCLEV--ESIDEGLVYAVYELYKKLN-TKLVITPTYSGRTAKLISKLRINSKIIA 378
Cdd:PRK05826 322 PVEAVEAMARICKGAEKEFSINLSKHRLDRqfDRIDEAIAMSAMYAANHLKgVKAIVALTESGRTARLISRFRPGAPIFA 401

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2497544   379 PTPNIRTLKRLRLVWGVESCLMEEFDDMEKIINTCREMAKKE--IGKG-IYLITLGHPIGQ 436
Cdd:PRK05826 402 VTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKglVESGdLVVVTSGDPMGT 462
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 5-447 9.77e-111

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 334.67  E-value: 9.77e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    5 MRKTKILVTLGPS------LENKLDKAINLidgVRFNMSHATTDY----CEKFLNILEK--NNIAKVMDLKGIKIRIKEV 72
Cdd:cd00288   1 LRRTKIVCTIGPAtdsvenLKKLIKAGMNV---ARMNFSHGSHEYhqsrIDNVREAAEKtgGPVAIALDTKGPEIRTGLF 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   73 KLKNKI-LKMGEKVVIGED----------IKLNY-NI-DTIEEGHFILINDGKIKLRVVEKTD--KIIAVVEVGGEIKEG 137
Cdd:cd00288  78 KGGKDIsLKAGDKFLVTTDpaakkgtkekIYVDYkNLtKDVSPGNTILVDDGLLSLKVLSKDDdkTLVCEVLNGGVLGSR 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544  138 MGVNLPDTRIELPIIDETDLKNIKFAVEKDFEYIALSFVRNKEDVKELKDIISEYKGDCEVISKIETKEGLKNIKEIARE 217
Cdd:cd00288 158 KGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEA 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544  218 SDGVMVARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETT 297
Cdd:cd00288 238 SDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 317

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544  298 IGKYPIEAIKVLNKVAKVAD---EHYEEFGDRVCLE------VESIDEGLVYAVYElykkLNTKLVITPTYSGRTAKLIS 368
Cdd:cd00288 318 KGKYPVEAVKAMARICLEAEkalSHRVLFNEMRRLTprptstTEAVAMSAVRAAFE----LGAKAIVVLTTSGRTARLVS 393

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544  369 KLRINSKIIAPTPNIRTLKRLRLVWGVESCLMEE-----FDDMEKIINTCREMAKKE--IGKG-IYLITLGHPIGQKKTN 440
Cdd:cd00288 394 KYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEpkpgwQEDTDARLKAAVNVAKEKglLKKGdLVVVVQGWPVGSGSTN 473


                ....*..
gi 2497544  441 TIKVESI 447
Cdd:cd00288 474 TMRILTV 480
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 5-317 2.85e-84

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 262.30  E-value: 2.85e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544      5 MRKTKILVTLGPSlENKLDKAINLIDG----VRFNMSHATTDYCEKFLN---ILEKN---NIAKVMDLKGIKIRIKEVKL 74
Cdd:pfam00224   1 LRRTKIVCTIGPA-SNSVENLEKLIEAganvARMNFSHGSHEYHQSRIDnvrEAEEKtggTVAIALDTKGPEIRTGNTKD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544     75 KNKI--LKMGEKVVIGED-----------IKLNY-NI-DTIEEGHFILINDGKIKLRVVEKTDKIIAVVEV--GGEIKEG 137
Cdd:pfam00224  80 GKKDieLKAGDEMIVSTDakykgacddemIYVDYkNIvKDVSVGGTILVDDGLLSLKVLSKDDDKTLVVEVlnGGVIGSR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    138 MGVNLPDTRIELPIIDETDLKNIKFAVEKDFEYIALSFVRNKEDVKELKDIISEYKGDCEVISKIETKEGLKNIKEIARE 217
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    218 SDGVMVARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETT 297
Cdd:pfam00224 240 TDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 319

                         330       340
                  ....*....|....*....|
gi 2497544    298 IGKYPIEAIKVLNKVAKVAD 317
Cdd:pfam00224 320 KGNYPVEAVRMMHEICLEAE 339
 
Name Accession Description Interval E-value
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 6-444 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 540.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544      6 RKTKILVTLGPSLENK--LDKAINL-IDGVRFNMSHATTDYCEKFLNILEK------NNIAKVMDLKGIKIRIKEVKLKN 76
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPemLKKLLDAgMNVARLNFSHGSHEEHGKRIENVREaaeklgRPVAILLDTKGPEIRTGEIKGGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544     77 KILKMGEKVVIG----------EDIKLNYN--IDTIEEGHFILINDGKIKLRVVEKT-DKIIAVVEVGGEIKEGMGVNLP 143
Cdd:TIGR01064  81 VKLKKGDKVIITtddikgegdeEKVYVDYKglTKDVVEGDKILVDDGKISLVVVSVEgDKVICEVLNGGTLKSKKGVNLP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    144 DTRIELPIIDETDLKNIKFAVEKDFEYIALSFVRNKEDVKELKDIISEYK-GDCEVISKIETKEGLKNIKEIARESDGVM 222
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNIDEIAEASDGIM 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    223 VARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETTIGKYP 302
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    303 IEAIKVLNKVAKVADE---HYEEFGDR--VCLEVESIDEGLVYAVYELYKKLNTKLVITPTYSGRTAKLISKLRINSKII 377
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKalaYLTNFNDRknSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2497544    378 APTPNIRTLKRLRLVWGVESCLMEEFDDM-----EKIINTCREMAKKEIGKGIYLITLGHPIGQKKTNTIKV 444
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPFLVDEEPSDtdarvNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 4-447 1.19e-175

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 499.95  E-value: 1.19e-175
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    4 MMRKTKILVTLGPSLEN--KLDKAINL-IDGVRFNMSHATTDYCEKFLNIL-----EKN-NIAKVMDLKGIKIRIKEVKl 74
Cdd:COG0469   1 MMRRTKIVATLGPASDSpeVLRKLIEAgMDVARLNFSHGDHEEHRERIELIreaakELGrPVAILLDLQGPKIRTGKFK- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   75 KNKI-LKMGEKVVI--------GEDIKLNYN--IDTIEEGHFILINDGKIKLRVVEKT-DKIIAVVEVGGEIKEGMGVNL 142
Cdd:COG0469  80 EGPVeLKKGDTFTLttddvegdAERVSVTYPelPEDVKPGDRILLDDGKIELRVEEVEgDEVVCEVVNGGVLSSRKGVNL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544  143 PDTRIELPIIDETDLKNIKFAVEKDFEYIALSFVRNKEDVKELKDIISEYKGDCEVISKIETKEGLKNIKEIARESDGVM 222
Cdd:COG0469 160 PGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIM 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544  223 VARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETTIGKYP 302
Cdd:COG0469 240 VARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYP 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544  303 IEAIKVLNKVAKVADEHYEEFGD---RVCLEVESIDEGLVYAVYELYKKLNTKLVITPTYSGRTAKLISKLRINSKIIAP 379
Cdd:COG0469 320 VEAVETMARIAEEAEKSLDYRRIldrLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILAL 399

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2497544  380 TPNIRTLKRLRLVWGVESCLMEEFDDMEKIINTCREMAKKE--IGKG-IYLITLGHPIGQK-KTNTIKVESI 447
Cdd:COG0469 400 TPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEglVKPGdLVVITAGVPVGVPgTTNTLKVHRV 471
PRK05826 PRK05826
pyruvate kinase; Provisional
 4-436 1.61e-136

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 400.30  E-value: 1.61e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544     4 MMRKTKILVTLGPSLENK--LDKAINL-IDGVRFNMSHATTDYCEKFLNIL----EKNN--IAKVMDLKGIKIRIKEVKL 74
Cdd:PRK05826   2 MLRRTKIVATLGPASDSPenLEKLIEAgVNVVRLNFSHGSHEEHGKRAALVreiaAKLGrpVAILLDLKGPKIRVGKFKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    75 KNKILKMGEKVVIG---------EDIKLNYN--IDTIEEGHFILINDGKIKLRVVEKT-DKIIAVVEVGGEIKEGMGVNL 142
Cdd:PRK05826  82 GKITLKTGDKFTLDtdqkeegdkERVGVDYKglPKDVKPGDILLLDDGKLQLKVVEVDgDEVETEVKNGGPLSNNKGINI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   143 PDTRIELPIIDETDLKNIKFAVEKDFEYIALSFVRNKEDVKELKDIISEYKG-DCEVISKIETKEGLKNIKEIARESDGV 221
Cdd:PRK05826 162 PGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCpHAKIIAKIERAEAVDNIDEIIEASDGI 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   222 MVARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETTIGKY 301
Cdd:PRK05826 242 MVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKY 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   302 PIEAIKVLNKVAKVADEHYEEFGDRVCLEV--ESIDEGLVYAVYELYKKLN-TKLVITPTYSGRTAKLISKLRINSKIIA 378
Cdd:PRK05826 322 PVEAVEAMARICKGAEKEFSINLSKHRLDRqfDRIDEAIAMSAMYAANHLKgVKAIVALTESGRTARLISRFRPGAPIFA 401

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2497544   379 PTPNIRTLKRLRLVWGVESCLMEEFDDMEKIINTCREMAKKE--IGKG-IYLITLGHPIGQ 436
Cdd:PRK05826 402 VTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKglVESGdLVVVTSGDPMGT 462
PRK06354 PRK06354
pyruvate kinase; Provisional
 4-447 6.29e-111

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 338.82  E-value: 6.29e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544     4 MMRKTKILVTLGPSLENKlDKAINLIDG----VRFNMSHAT-TDYCEKFLNILE-----KNNIAKVMDLKGIKIRIKE-- 71
Cdd:PRK06354   6 LMRRTKIVATIGPASESP-EKLRQLIEAgattARLNFSHGDhEEHGARIKNIREaskklGKTVGILQDLQGPKIRLGRfe 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    72 ---VKLKNK---ILKMGEKVVIGEDIKLNYN--IDTIEEGHFILINDGKIKLRV--VEKTDK-IIAVVEVGGEIKEGMGV 140
Cdd:PRK06354  85 dgpIELKTGdefILTSREVLGTQEKFSVTYDglADEVPVGSRILLDDGLIELEVeeVDKADGeLHCKVLVGGVLSNKKGV 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   141 NLPDTRIELPIIDETDLKNIKFAVEKDFEYIALSFVRNKEDVKELKDIISEYKG-DCEVISKIETKEGLKNIKEIARESD 219
Cdd:PRK06354 165 NFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGkHIPIIAKIEKQEAIDNIDAILELCD 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   220 GVMVARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETTIG 299
Cdd:PRK06354 245 GLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAG 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   300 KYPIEAIKVLNKVAKVADEHY--EEFGDRVCLEVESIDEGLVYAVYELYKKLNTKLVITPTYSGRTAKLISKLRINSKII 377
Cdd:PRK06354 325 DYPVEAVQTMATIAVRIEKDLpyRDILSKRPEFTTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTPIL 404

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2497544   378 APTPNIRTLKRLRLVWGVESCLMEEFDDMEKIINTCREMAKKE--IGKG-IYLITLGHPIGQK-KTNTIKVESI 447
Cdd:PRK06354 405 AVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESglLKQGdLVVITAGTLVGESgSTDLMKVHVV 478
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 5-447 9.77e-111

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 334.67  E-value: 9.77e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    5 MRKTKILVTLGPS------LENKLDKAINLidgVRFNMSHATTDY----CEKFLNILEK--NNIAKVMDLKGIKIRIKEV 72
Cdd:cd00288   1 LRRTKIVCTIGPAtdsvenLKKLIKAGMNV---ARMNFSHGSHEYhqsrIDNVREAAEKtgGPVAIALDTKGPEIRTGLF 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   73 KLKNKI-LKMGEKVVIGED----------IKLNY-NI-DTIEEGHFILINDGKIKLRVVEKTD--KIIAVVEVGGEIKEG 137
Cdd:cd00288  78 KGGKDIsLKAGDKFLVTTDpaakkgtkekIYVDYkNLtKDVSPGNTILVDDGLLSLKVLSKDDdkTLVCEVLNGGVLGSR 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544  138 MGVNLPDTRIELPIIDETDLKNIKFAVEKDFEYIALSFVRNKEDVKELKDIISEYKGDCEVISKIETKEGLKNIKEIARE 217
Cdd:cd00288 158 KGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEA 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544  218 SDGVMVARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETT 297
Cdd:cd00288 238 SDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 317

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544  298 IGKYPIEAIKVLNKVAKVAD---EHYEEFGDRVCLE------VESIDEGLVYAVYElykkLNTKLVITPTYSGRTAKLIS 368
Cdd:cd00288 318 KGKYPVEAVKAMARICLEAEkalSHRVLFNEMRRLTprptstTEAVAMSAVRAAFE----LGAKAIVVLTTSGRTARLVS 393

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544  369 KLRINSKIIAPTPNIRTLKRLRLVWGVESCLMEE-----FDDMEKIINTCREMAKKE--IGKG-IYLITLGHPIGQKKTN 440
Cdd:cd00288 394 KYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEpkpgwQEDTDARLKAAVNVAKEKglLKKGdLVVVVQGWPVGSGSTN 473


                ....*..
gi 2497544  441 TIKVESI 447
Cdd:cd00288 474 TMRILTV 480
PRK06247 PRK06247
pyruvate kinase; Provisional
 4-447 1.68e-106

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 323.80  E-value: 1.68e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544     4 MMRKTKILVTLGPSLEN-----KLDKAinLIDGVRFNMSHAT-TDYCEKFLNI--LEKNN---IAKVMDLKGIKIRIKEV 72
Cdd:PRK06247   3 RNRRVKILATLGPASSSedmirKLVEA--GADVFRLNFSHGDhDDHRELYKRIreVEDETgrpIGILADLQGPKLRLGRF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    73 KLKNKILKMGEKVVIGED--------IKLNYN--IDTIEEGHFILINDGKIKLRVVEKT-DKIIAVVEVGGEIKEGMGVN 141
Cdd:PRK06247  81 ADGKVQLANGQTFRLDVDdapgdhdrVSLPHPeiAAALKPGDRLLVDDGKVRLVVEACDgDDVVCRVVEGGPVSDRKGVS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   142 LPDTRIELPIIDETDLKNIKFAVEKDFEYIALSFVRNKEDVKELKDIIseyKGDCEVISKIETKEGLKNIKEIARESDGV 221
Cdd:PRK06247 161 LPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKII---GGRVPVMAKIEKPQAIDRLEAIVEASDAI 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   222 MVARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETTIGKY 301
Cdd:PRK06247 238 MVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKY 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   302 PIEAIKVLNKVAKVA--DEHYEEFGDRVCLEVESIDEGLV-YAVYELYKKLNTKLVITPTYSGRTAKLISKLRINSKIIA 378
Cdd:PRK06247 318 PVEAVRTMARIIRQVerDPTYPPLIHAQRPQPEATKRDAIsYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILA 397

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2497544   379 PTPNIRTLKRLRLVWGVESCLMEEFDDMEKIINT-CREMAKKEIGKG--IYLITLGHPIGQK-KTNTIKVESI 447
Cdd:PRK06247 398 LTPNPETARRLALTWGVHCVVVDDARDTDDMVRRaDRIALAEGFYKRgdRVVIVAGVPPGTPgSTNMLRIAYI 470
PRK09206 PRK09206
pyruvate kinase PykF;
5-445 3.37e-95

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 294.65  E-value: 3.37e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544     5 MRKTKILVTLGPSLENKlDKAINLIDG----VRFNMSHAttDYCE------KFLNILEKNN--IAKVMDLKGIKIRIKEV 72
Cdd:PRK09206   1 MKKTKIVCTIGPKTESE-EMLTKLLDAgmnvMRLNFSHG--DYAEhgqrikNLRNVMSKTGkkAAILLDTKGPEIRTMKL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    73 KLKNKI-LKMGEKVVIGEDIKLNYNIDTI-----------EEGHFILINDGKIKLRVVEKTD-KIIAVVEVGGEIKEGMG 139
Cdd:PRK09206  78 EGGNDVsLKAGQTFTFTTDKSVVGNKERVavtyegftadlSVGNTVLVDDGLIGMEVTAITGnEVICKVLNNGDLGENKG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   140 VNLPDTRIELPIIDETDLKNIKFAVEKDFEYIALSFVRNKEDVKELKDIISEYKGD-CEVISKIETKEGLKNIKEIARES 218
Cdd:PRK09206 158 VNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGEnIQIISKIENQEGLNNFDEILEAS 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   219 DGVMVARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETTI 298
Cdd:PRK09206 238 DGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAK 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   299 GKYPIEAIKVLNKVAKVADE----HYEEFGDRVCLEV-ESIDEGLVyavyELYKKLNTKLVITPTYSGRTAKLISKLRIN 373
Cdd:PRK09206 318 GKYPLEAVSIMATICERTDRvmnsRLESNNDNRKLRItEAVCRGAV----ETAEKLDAPLIVVATQGGKSARSVRKYFPD 393

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2497544   374 SKIIAPTPNIRTLKRLRLVWGVESCLMEEFDDMEKIINTCREMAKK--EIGKG-IYLITLGHPIGQKKTNTIKVE 445
Cdd:PRK09206 394 ATILALTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQsgLAQKGdVVVMVSGALVPSGTTNTASVH 468
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 6-420 1.23e-85

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 271.25  E-value: 1.23e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544     6 RKTKILVTLGPSLENkLDKAINLIDG----VRFNMSHAT-TDYCEKFLNILE------KNNIAKVMDLKGIKIRIKEVKL 74
Cdd:PTZ00066  38 KKTHIVCTMGPACKN-VETLVKLIDAgmniCRFNFSHGDhESHKKTLNNVREaakarpNANLGILLDTKGPEIRTGFLKN 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    75 KNKI-LKMGEKVVIGED---------IKLNYNI--DTIEEGHFILINDGKIKLRVVEKTDK-IIAVVEVGGEIKEGMGVN 141
Cdd:PTZ00066 117 HKPItLKEGQTLKITTDytflgdetcISCSYKKlpQSVKVGNIILIADGSLSCKVLEVHDDyIITKVLNNATIGERKNMN 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   142 LPDTRIELPIIDETDLKNI-KFAVEKDFEYIALSFVRNKEDVKELKDIISEYKGDCEVISKIETKEGLKNIKEIARESDG 220
Cdd:PTZ00066 197 LPGVKVELPVIGEKDKNDIlNFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILAESDG 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   221 VMVARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETTIGK 300
Cdd:PTZ00066 277 IMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGK 356

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   301 YPIEAIKVLNKVAKVADE--HYEEFGDRVCLEVE---SIDEGLVYAVYELYKKLNTKLVITPTYSGRTAKLISKLRINSK 375
Cdd:PTZ00066 357 FPVEAVNIMAKICFEAETciDYRVLYHAIHLAVPtpvSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYRPSCT 436

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 2497544   376 IIAPTPNIRTLKRLRLVWGVESCLMEEFDDMEKIINTCREMAKKE 420
Cdd:PTZ00066 437 ILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKER 481
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 5-317 2.85e-84

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 262.30  E-value: 2.85e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544      5 MRKTKILVTLGPSlENKLDKAINLIDG----VRFNMSHATTDYCEKFLN---ILEKN---NIAKVMDLKGIKIRIKEVKL 74
Cdd:pfam00224   1 LRRTKIVCTIGPA-SNSVENLEKLIEAganvARMNFSHGSHEYHQSRIDnvrEAEEKtggTVAIALDTKGPEIRTGNTKD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544     75 KNKI--LKMGEKVVIGED-----------IKLNY-NI-DTIEEGHFILINDGKIKLRVVEKTDKIIAVVEV--GGEIKEG 137
Cdd:pfam00224  80 GKKDieLKAGDEMIVSTDakykgacddemIYVDYkNIvKDVSVGGTILVDDGLLSLKVLSKDDDKTLVVEVlnGGVIGSR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    138 MGVNLPDTRIELPIIDETDLKNIKFAVEKDFEYIALSFVRNKEDVKELKDIISEYKGDCEVISKIETKEGLKNIKEIARE 217
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    218 SDGVMVARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETT 297
Cdd:pfam00224 240 TDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 319

                         330       340
                  ....*....|....*....|
gi 2497544    298 IGKYPIEAIKVLNKVAKVAD 317
Cdd:pfam00224 320 KGNYPVEAVRMMHEICLEAE 339
PLN02461 PLN02461
Probable pyruvate kinase
 7-371 1.34e-75

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 244.89  E-value: 1.34e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544     7 KTKILVTLGPS------LENKLDKAINLidgVRFNMSHATTDYCEKFLNILEK--NN---IAKVM-DLKGIKIRIKEVKL 74
Cdd:PLN02461  22 KTKIVCTLGPAsrsvpmLEKLLRAGMNV---ARFNFSHGSHEYHQETLDNLRQamANtgiLCAVMlDTKGPEIRTGFLKD 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    75 KNKI-LKMGEKVVIGEDIKLNYNIDTI-----------EEGHFILINDGKIKLRVVEkTDKIIAVVEVGGE----IKEGM 138
Cdd:PLN02461  99 GKPVqLKQGQEITITTDYSIKGDENMIamsykklavdvKPGSVILCADGTITLTVLS-CDVEAGTVRCRCEnsamLGERK 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   139 GVNLPDTRIELPIIDETDLKNI-KFAVEKDFEYIALSFVRNKEDVKELKDIISEYKGDCEVISKIETKEGLKNIKEIARE 217
Cdd:PLN02461 178 NVNLPGVVVDLPTLTEKDKEDIlQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNFDDILAE 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   218 SDGVMVARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETT 297
Cdd:PLN02461 258 SDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETA 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   298 IGKYPIEAIKVLNKVAKVADEH------YEEFGDRVCLEVESIdEGLVYAVYELYKKLNTKLVITPTYSGRTAKLISKLR 371
Cdd:PLN02461 338 AGAYPELAVKTMARICREAEASldygalFKEIMRSAPLPMSPL-ESLASSAVRTANKVKASLIVVLTRGGTTARLVAKYR 416
PRK06739 PRK06739
pyruvate kinase; Validated
 13-336 1.45e-74

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 237.54  E-value: 1.45e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    13 TLGPSLENKLDKAINLIDG---VRFNMSHATTDYCEKFLNILEK-NNIAKVM-DLKGIKIRIKEVKLKNKILKMGEKVVI 87
Cdd:PRK06739   8 TIGPASNNKETLAQLINNGmkiVRLNLSHGTHESHKDIIRLVKSlDDSIKILgDVQGPKIRLGEIKGEQITLQAGDSFIL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    88 --------GEDIKLNYN--IDTIEEGHFILINDGKIKLrVVEK--TDKIIAVVEVGGEIKEGMGVNLPDTRIELPIIDET 155
Cdd:PRK06739  88 htqpvtgsSTEASVDYEgiANDVKVGSRILMNDGEVEL-IVEKvsTDKIETKVKTGGNISSHKGVNLPGAIVRLPAITEK 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   156 DLKNIKFAVEKDFEYIALSFVRNKEDVKELKDIISEYKGDC-EVISKIETKEGLKNIKEIARESDGVMVARGDLGVEVPI 234
Cdd:PRK06739 167 DKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKIETMEAIENFQDICKEADGIMIARGDLGVELPY 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   235 ENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETTIGKYPIEAIKVLNKVAK 314
Cdd:PRK06739 247 QFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVSTLRLVSE 326

                        330       340
                 ....*....|....*....|....*..
gi 2497544   315 VAdEHYEEFG-----DRVCLEVESIDE 336
Cdd:PRK06739 327 FA-EHVKKDGpfvmkDVLELLHKSLDE 352
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 32-409 1.83e-74

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 240.34  E-value: 1.83e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    32 VRFNMSHATTDYCEKFLNILEKN------NIAKVMDLKGIKIRIKEVKLKNKILKMGEKVVIGED-------IKLNYNID 98
Cdd:PTZ00300   4 ARMNFSHGSHEYHQTTINNVRQAaaelgvNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDpafadkgTKDKFYID 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    99 ------TIEEGHFILINDGKIKLRVVEKTDK--IIAVVEVGGEIKEGMGVNLPDTRIELPIIDETDLKNIKFAVEKDFEY 170
Cdd:PTZ00300  84 yqnlskVVRPGGYIYIDDGILILHVQSHEDEqtLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQGVDM 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   171 IALSFVRNKEDVKELKDIISEYKGDCEVISKIETKEGLKNIKEIARESDGVMVARGDLGVEVPIENIPIEQKNILRIANR 250
Cdd:PTZ00300 164 IFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCNV 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   251 YGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETTIGKYPIEAIKVLNKV---AKVADEHYEEFGDRV 327
Cdd:PTZ00300 244 AGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARIcleAQSAVNEYVFFNSIK 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   328 CLEV------ESIDEGLVYAVYElykkLNTKLVITPTYSGRTAKLISKLRINSKIIAPTPNIRTLKRLRLVWGVESClme 401
Cdd:PTZ00300 324 KLQPipmsaeEAVCSSAVNSVYE----TKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESV--- 396


                 ....*...
gi 2497544   402 eFDDMEKI 409
Cdd:PTZ00300 397 -FFDAERL 403
PLN02623 PLN02623
pyruvate kinase
 6-408 1.26e-71

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 236.36  E-value: 1.26e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544     6 RKTKILVTLGPSLEN-----KLDKA-INLidgVRFNMSHA-------TTDYCEKFLNILEKNNIAKVMDLKGIKIRIKEV 72
Cdd:PLN02623 110 RKTKIVCTIGPSTNTremiwKLAEAgMNV---ARLNMSHGdhashqkVIDLVKEYNAQSKDNVIAIMLDTKGPEVRSGDL 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    73 KlKNKILKMGEK--------VVIGEDIKLNYN--IDTIEEGHFILINDGKIKLRVVEKT-DKIIAVVEVGGEIKEGMGVN 141
Cdd:PLN02623 187 P-QPIMLEEGQEftftikrgVSTEDCVSVNYDdfVNDVEVGDMLLVDGGMMSLAVKSKTsDSVKCEVVDGGELKSRRHLN 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   142 LPDTRIELPIIDETDLKNIKFAVEKDFEYIALSFVRNKEDVKELKDIISEYKGDCEVISKIETKEGLKNIKEIARESDGV 221
Cdd:PLN02623 266 VRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIPNLHSIITASDGA 345

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   222 MVARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETTIGKY 301
Cdd:PLN02623 346 MVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKF 425

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   302 PIEAIKVLNKVAkVADEHYEEFGDRVCLEVES----IDEGLVYAVYELYKKLNTKLVITpTYSGRTAKLISKLRINSKII 377
Cdd:PLN02623 426 PLKAVKVMHTVA-LRTEATLPEGTTPPNLGQAfknhMSEMFAFHATMMANTLGTSIIVF-TRTGFMAILLSHYRPSGTIF 503

                        410       420       430
                 ....*....|....*....|....*....|.
gi 2497544   378 APTPNIRTLKRLRLVWGVESCLMEEFDDMEK 408
Cdd:PLN02623 504 AFTNEKRIQQRLALYQGVCPIYMQFSDDAEE 534
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 5-411 1.31e-59

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 203.05  E-value: 1.31e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544     5 MRKTKILVTLGP---SLENKLDKAINLIDGVRFNMSHATTDYCE------KFLNILEKNNIAKVMDLKGIKIRIKEVKlk 75
Cdd:PLN02762  24 TRRTKLVCTIGPaccGFEQLEALAMGGMNVARLNMCHGTREWHRdvirrvRRLNEEKGFAVAVMMDTEGSEIHMGDLG-- 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    76 nkilkmGEKVVIGED-------------------IKLNYN--IDTIEEGHFILINDGKIKLRVVEKtdkiiavveVGGEI 134
Cdd:PLN02762 102 ------GASSAKAEDgeewtftvrkfdgsrpeftIQVNYDgfAEDVKVGDELVVDGGMVRFEVIEK---------IGPDV 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   135 K---EGMGVNLP--------------DTRIELPIIDETDLKNIKFAVEKDFEYIALSFVRNKEDVKELKDIIS--EYKGD 195
Cdd:PLN02762 167 KckcTDPGLLLPranltfwrdgslvrERNAMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAarSRDSD 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   196 CEVISKIETKEGLKNIKEIARESDGVMVARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAE 275
Cdd:PLN02762 247 IGVIAKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAE 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   276 VTDIANAIYDGTDCLMLSNETTIGKYPIEAIKVLNKVAKVADEHYEEFGDRVCLEV--------ESIDEGLVYAVYELYK 347
Cdd:PLN02762 327 VADVSEAVRQRADALMLSGESAMGLYPEKALSVLRSVSLRMELWSREEKRHEALELpqlssslsDRISEEICNSAAKMAN 406

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2497544   348 KLNTKLVITPTYSGRTAKLISKLRINSKIIAPTPNIRTLKRLRLVWGVESCLMEEFDDMEKIIN 411
Cdd:PLN02762 407 NLGVDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLN 470
PLN02765 PLN02765
pyruvate kinase
 8-378 5.40e-51

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 180.25  E-value: 5.40e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544     8 TKILVTLGPS------LENKLDKAINLidgVRFNMSHATTDYCEKFLNILEK--NNIAK---VM-DLKGIKIRIKEvKLK 75
Cdd:PLN02765  30 TKIVGTLGPKsrsvevIEACLKAGMSV---ARFDFSWGDAEYHQETLENLKIavKNTKKlcaVMlDTVGPELQVIN-KTE 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    76 NKI-LKMGEKVVIGEDIK---------LNYNI--------DTIEEGHFIL--INDGKIKLRVVE-KTDKIIAVVE----V 130
Cdd:PLN02765 106 KPIsLKAGNTVTLTPDQSkeassevlpINFPGlakavkpgDTIFVGQYLFtgSETTSVWLEVDEvKGDDVVCTVKnsatL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   131 GGEIkegMGVNLPDTRIELPIIDETDLKNIK-FAVEKDFEYIALSFVRNKEDVKELKDIISEYK-GDCEVISKIETKEGL 208
Cdd:PLN02765 186 AGSL---FTLHVSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIFAKIENVEGL 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   209 KNIKEIARESDGVMVARGDLGVEVPIENIPIEQKNILRIANRYGILSITaTQILDSMINNPFPTRAEVTDIANAIYDGTD 288
Cdd:PLN02765 263 THFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGAD 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   289 CLMLSNETTIGKYPIEAIKVLNKVAKVA------DEHY----EEFGDRVClEVESIDEGLVYAVYelykKLNTKLVITPT 358
Cdd:PLN02765 342 AILLGAETLRGLYPVETISTVGRICAEAekvfnqDLYFkktvKYVGEPMS-HLESIASSAVRAAI----KVKASVIIVFT 416

                        410       420
                 ....*....|....*....|
gi 2497544   359 YSGRTAKLISKLRINSKIIA 378
Cdd:PLN02765 417 SSGRAARLIAKYRPTMPVLS 436
PRK14725 PRK14725
pyruvate kinase; Provisional
 97-320 6.82e-43

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 159.34  E-value: 6.82e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    97 IDTIEEGHFILINDGKIKLRVVEKTD-----KIIAVVEVGGEIKEGMGVNLPDTRIELPIIDETDLKNIKFAVeKDFEYI 171
Cdd:PRK14725 370 FRAARVGERVWFDDGKIGAVVVKVEAdevelRITHARPGGSKLKAGKGINLPDSHLPLPALTDKDLEDLAFVA-KHADIV 448

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   172 ALSFVRNKEDVKELKDIISEYKG-DCEVISKIETKEGLKNIKEI-----ARESDGVMVARGDLGVEVPIENIPIEQKNIL 245
Cdd:PRK14725 449 ALSFVRSPEDVRLLLDALEKLGAdDLGVVLKIETRRAFENLPRIlleamRHPRFGVMIARGDLAVEVGFERLAEVQEEIL 528

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2497544   246 RIANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYdgTDCLMLsNEttiGKYPIEAIKVLNKVAKVADEHY 320
Cdd:PRK14725 529 WLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVML-NK---GPHIVEAVRVLDDILRRMEEHQ 597
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
247-447 8.57e-37

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 137.34  E-value: 8.57e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544  247 IANRYGILSITATQILDSMINNPFPTRAEVTDIANAIYDGTDCLMLSNETTIGKYPIEAIKVLNKVAKVADEHYEEFGDR 326
Cdd:COG3848   1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544  327 VCLEVES---IDEGLVYAVYELYKKLNTKLVITPTYSGRTAKLISKLRINSKIIAPTPNIRTLKRLRLVWGVESCLMEEF 403
Cdd:COG3848  81 VPRAKESsttITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEES 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 2497544  404 DD----MEKIINTCREmaKKEIGKG-IYLITLGHPIGQK-KTNTIKVESI 447
Cdd:COG3848 161 AStdemFAVAVALALE--AGLVKDGdLVVITAGVPVGVSgTTNLLKVHVV 208
PRK08187 PRK08187
pyruvate kinase; Validated
 6-319 3.87e-36

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 138.99  E-value: 3.87e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544     6 RKTKILVTLGPSLENKLDKAINLI----DGVRFNMSHATTDYCEKFLNILEKNNIA-----KV-MDLKGIKIRIKEV--K 73
Cdd:PRK08187 133 RRTRIMVTLPSEAADDPDFVLRLAergmDCARINCAHDDPAAWQAMIGHLRQAERAtgrrcKIlMDLAGPKIRTGAVagP 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    74 LKNKILKMGEKVVIGEDIKLNYNIDT--------------IEEGHFILINDGKIKLRVVEKTD-----KIIAVVEVGGEI 134
Cdd:PRK08187 213 LGKTRLYTGDRLALVAQGPPRRIDEEhfqvtctlpeilarLAVGARVWIDDGKLGARVERVGPggallEVTHARPKGLKL 292

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   135 KEGMGVNLPDTRIELPIIDETDLKNIKFAVEKDfEYIALSFVRNKEDVKELKDIISEYKGDCE----VISKIETKEGLKN 210
Cdd:PRK08187 293 KPEKGLNFPDTALDLPALTEKDRADLDFVARHA-DLVGYSFVQSPGDVEALQAALAARRPDDWrklgLVLKIETPRAVAN 371

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544   211 IKEI-----ARESDGVMVARGDLGVEVPIENIPIEQKNILRIANRYGILSITATQILDSMINNPFPTRAEVTDIANAiyD 285
Cdd:PRK08187 372 LPELivqaaGRQPFGVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMA--A 449

                        330       340       350
                 ....*....|....*....|....*....|....
gi 2497544   286 GTDCLMLSNettiGKYPIEAIKVLNKVAKVADEH 319
Cdd:PRK08187 450 RAECVMLNK----GPYLVEAVTFLDDLLARMDGH 479
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 336-444 2.52e-21

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 88.69  E-value: 2.52e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2497544    336 EGLVYAVYELYKKLNTKLVITPTYSGRTAKLISKLRINSKIIAPTPNIRTLKRLRLVWGVESCLMEEFDDMEKIINTCRE 415
Cdd:pfam02887   1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVK 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2497544    416 MAKKE--IGKG-IYLITLGHPIGQK-KTNTIKV 444
Cdd:pfam02887  81 VAKEAglVKKGdLVVITAGVPFGVSgTTNTLKV 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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