|
Name |
Accession |
Description |
Interval |
E-value |
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
4-931 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1439.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 4 YRKTLNMPDTPFPMRGDLAKREPGWVADWQAKKLYQKVRKAAAGRPKFVLHDGPPYANGDIHIGHAVNKILKDIIVRSKT 83
Cdd:COG0060 1 YKETLNLPKTDFPMRANLPKREPEILKFWEENDIYEKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 84 LAGFDAPYVPGWDCHGLPIEHQIEKQHGKH------LPADRARELCREYAAEQIERQKKDFIRLGVLGDWDNPYRTMNFS 157
Cdd:COG0060 81 MRGFDVPYVPGWDCHGLPIELKVEKELGIKkkdiekVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 158 NEADEIRALGELFRKGFLFKGLKPVNWCFDCGSALAEAEVEYQDKKSPAIDVGFPLVDnerdklahafGLDTLPEQPVYI 237
Cdd:COG0060 161 YEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKDVTSPSIYVKFPVKD----------EKALLLLEDAYL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 238 VIWTTTPWTIPSNQALNVHPELIYELVETPKG-LLILAAELRASALERYQLEG-RVLAAARGVALDRINFRHPFY----- 310
Cdd:COG0060 231 VIWTTTPWTLPANLAVAVHPDIDYVLVEVTGGeRLILAEALVEAVLKELGIEDyEVLATFKGAELEGLRYEHPFYyvvgy 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 311 DRLSPVFLGDYVAADAGTGIVHSAPAYGLDDFVSCTRYGMrndEILNPVQADGTFAGSLPFFGGLSVWDANPKIVDKLAE 390
Cdd:COG0060 311 DRAHPVILGDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGL---PVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKE 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 391 VGSLFASGTLTHSYMHCWRHKTPVIYRATTQWFVGMDRLpgreavepgsatlRELALKAVDETQFYPAWGKARLHSMIAN 470
Cdd:COG0060 388 RGALLAREKITHSYPHCWRCKTPLIYRATPQWFISMDKL-------------RDRALEAIEKVNWIPEWGEGRFGNMLEN 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 471 RPDWCVSRQRNWGVPIPLFLHKETGEPHpRSLELLEQVAQRVEQHGIDAWFKLDAAE-LLGSDV------AQYDKMRDTL 543
Cdd:COG0060 455 RPDWCISRQRYWGVPIPIWVCEDCGELH-RTEEVIGSVAELLEEEGADAWFELDLHRpFLDETLkcpkcgGTMRRVPDVL 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 544 DVWFDSGTTHWTVLRGSHaaDSQWPAALYLEGSDQHRGWFHSSLLTGCAIDGRAPYDALLTHGFVVDGQGKKMSKSKGNV 623
Cdd:COG0060 534 DVWFDSGSMHFAVLENRE--ELHFPADFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNV 611
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 624 VAPQEVSDKLGAEILRLWVAATDYSGELTISKEILDRVVEVYRRLRNTLRFLLANTGDFDIARDGVPVEEWLDIDHYALA 703
Cdd:COG0060 612 VDPQEVIDKYGADILRLWVASSDYWGDLRFSDEILKEVRDVYRRLRNTYRFLLANLDDFDPAEDAVPYEDLPELDRWILS 691
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 704 LTRRLQEQVTGDYARFEFHKIVQALQNFAAEDLGAFYVDILKDRLYTTKADSRARRAAQTALWHITQAITRMMAPILTFT 783
Cdd:COG0060 692 RLNELIKEVTEAYDNYDFHRAYRALHNFCVEDLSNWYLDISKDRLYTEAADSLDRRAAQTTLYEVLETLVRLLAPILPFT 771
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 784 AEEIWRVTGNDAEDSVMLHTWHELPELGASDEILARWELIRSARAEVQKVLESLRSDGRIGASLQAEVRVRASGARFDAL 863
Cdd:COG0060 772 AEEIWQNLPGEAEESVHLADWPEVDEELIDEELEAKWDLVREVRSAVLKALEAARKEKLIRQPLEAAVVLYADEELAAAL 851
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 864 ASVGADLHFVLITSRAELVRVETEADEG-------------VDAAPSSHQKCGRCWHFRedIGVDADHPELCGRCCTNLH 930
Cdd:COG0060 852 ESLGDLLAEELNVSEVELVDDAEDLGKDalkaldvegisvtVEVEKADGEKCERCWHYE--VGWTPEHEGLCRRCVRRVQ 929
|
.
gi 81821070 931 G 931
Cdd:COG0060 930 G 930
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
14-853 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 918.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 14 PFPMRGDLAKREPGWVADWQAKKLYQKVRKAAAGRPKFVLHDGPPYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVP 93
Cdd:TIGR00392 1 KFPMRGNLSKREEKILAFWQENDIFEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 94 GWDCHGLPIEHQIEKQHGKHLPADRA-------RELCREYAAEQIERQKKDFIRLGVLGDWDNPYRTMNFSNEADEIRAL 166
Cdd:TIGR00392 81 GWDTHGLPIEHKVEKKLGISGKKEISsleieefREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 167 GELFRKGFLFKGLKPVNWCFDCGSALAEAEVEYQ----DKKSPAIDVGFPLVDNERDKLAHAFGldtlpeqpvYIVIWTT 242
Cdd:TIGR00392 161 KEAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYKenykDVKDPSIYVKFPVKKDKKTYLKVKLS---------SLLIWTT 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 243 TPWTIPSNQALNVHPELIYELVETPKG--LLILAAELRASALERYQLEGRVLAAARGVALDRINFRHPFYDRLSP----- 315
Cdd:TIGR00392 232 TPWTLPSNLAIAVHPDFEYALVQDNTKveYFILAKKLVEKLYNKAGSDYEIIKTFKGSDLEGLEYEHPLYDFVSQlkega 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 316 --VFLGDYVAADAGTGIVHSAPAYGLDDFVSCTRYGMrndEILNPVQADGTF-------AGSLPFFGGLSVWDANPKIVD 386
Cdd:TIGR00392 312 pvVIGGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGL---EVLSPVDEKGVYtegvndfQGRFVKDADKDIIKANKIIIE 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 387 KLAEVGSLFASGTLTHSYMHCWRHKTPVIYRATTQWFVGMdrlpgreavepgsATLRELALKAVDETQFYPAWGKARLHS 466
Cdd:TIGR00392 389 QLKDKGLLLKAEKITHSYPHCWRTKTPVIYRATEQWFIKT-------------KDIKDQMLEQIKKVNWVPEWGEGRFGN 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 467 MIANRPDWCVSRQRNWGVPIPLFLHKETGEphPRSLELLEQVAQRVEQHGIDAWFKLDAAELLG------SDVAQYDKMR 540
Cdd:TIGR00392 456 WLENRPDWCISRQRYWGIPIPIWYCEDTGE--PIVVGSIEELIELIELKGIDAWFEDLHRDFLDkitlksGDGGEYRRVP 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 541 DTLDVWFDSGTTHWTVLR---GSHAADSQWPAALYLEGSDQHRGWFHSSLLTGCAIDGRAPYDALLTHGFVVDGQGKKMS 617
Cdd:TIGR00392 534 DVLDVWFDSGSMPYASIHypfENEKFKEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMS 613
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 618 KSKGNVVAPQEVSDKLGAEILRLWVAATDYSGELTISKEILDRVVEVYRRLR-NTLRFLL--ANTGDFDIARDGVPVEEW 694
Cdd:TIGR00392 614 KSLGNVVDPLKVINKYGADILRLYVASSDPWEDLRFSDEILKQVVEKYRKIRwNTYRFLLtyANLDKFDPLFNSVAVEKF 693
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 695 LDIDHYALALTRRLQEQVTGDYARFEFHKIVQALQNFAAEDLGAFYVDILKDRLYTTKADSrARRAAQTALWHITQAITR 774
Cdd:TIGR00392 694 PEEDRWILSRLNSLVEEVNEALEKYNFHKVLRALQDFIVEELSNWYIRIIRDRLYCEAKDN-DKRAAQTTLYYALLTLVR 772
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 775 MMAPILTFTAEEIWR-VTGNDAEDSVMLHTWHE------LPELGASDEILAR-WELIRSARAEVQKVLESLRSDGRIGAS 846
Cdd:TIGR00392 773 LLAPFLPHTAEEIYQnLPGGEEEESVHLNLWPEvdeefiDEALEANMAIVREiVEAFLALRDAANKKLRQPLKELVIGKS 852
|
....*..
gi 81821070 847 LQAEVRV 853
Cdd:TIGR00392 853 LEAVLKA 859
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
17-925 |
0e+00 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 833.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 17 MRGDLAKREPGWVADWQAKKLYQKVRKAAAGRPkFVLHDGPPYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWD 96
Cdd:PLN02843 1 MRANSVTREPEIQKLWEENQVYKRVSDRNNGES-FTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 97 CHGLPIE----HQIEKQHGKHLPADRARELCREYAAEQIERQKKDFIRLGVLGDWDNPYRTMNFSNEADEIRALGELFRK 172
Cdd:PLN02843 80 CHGLPIElkvlQSLDQEARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 173 GFLFKGLKPVNWCFDCGSALAEAEVEY-QDKKSPAIDVGFPLVD-NERDKLAHAFGLDTLpeqpvYIVIWTTTPWTIPSN 250
Cdd:PLN02843 160 GYIYRGRKPVHWSPSSRTALAEAELEYpEGHVSKSIYVAFPVVSpSETSPEELEEFLPGL-----SLAIWTTTPWTMPAN 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 251 QALNVHPELIYELVETP-------------------------KGLLILAAELRASALERYQLEGRVLAAARGVALDRINF 305
Cdd:PLN02843 235 AAVAVNDKLQYSVVEVQsfsedestsggnkkkrpgnvlkeqqKLFLIVATDLVPALEAKWGVKLVVLKTFPGSDLEGCRY 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 306 RHPFYDRLSPVFL-GDYVAADAGTGIVHSAPAYGLDDFVSCTRYGMrndEILNPVQADGTFAGSLPFFGGLSVW-DANPK 383
Cdd:PLN02843 315 IHPLYNRESPVVIgGDYITTESGTGLVHTAPGHGQEDYITGLKYGL---PLLSPVDDAGKFTEEAGQFSGLSVLgEGNAA 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 384 IVDKLAEVGSLFASGTLTHSYMHCWRHKTPVIYRATTQWFVgmdrlpgreAVEpgsaTLRELALKAVDETQFYPAWGKAR 463
Cdd:PLN02843 392 VVEALDEAGSLLMEEAYGHKYPYDWRTKKPTIFRATEQWFA---------SVE----GFRQAALDAIDKVKWIPAQGENR 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 464 LHSMIANRPDWCVSRQRNWGVPIPLFLHKETGEPHPRSlELLEQVAQRVEQHGIDAWFKLDAAELLGSD----VAQYDKM 539
Cdd:PLN02843 459 IRAMVSGRSDWCISRQRTWGVPIPVFYHVETKEPLMNE-ETIAHVKSIVAQKGSDAWWYMDVEDLLPEKyrdkASDYEKG 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 540 RDTLDVWFDSGTThWTVLRGSHAADSqWPAALYLEGSDQHRGWFHSSLLTGCAIDGRAPYDALLTHGFVVDGQGKKMSKS 619
Cdd:PLN02843 538 TDTMDVWFDSGSS-WAGVLGSREGLS-YPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKS 615
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 620 KGNVVAPQEV-----SDKL----GAEILRLWVAATDYSGELTISKEILDRVVEVYRRLRNTLRFLLANTGDFDiARDGVP 690
Cdd:PLN02843 616 LGNVVDPRLVieggkNQKQepayGADVLRLWVASVDYTGDVLIGPQILKQMSDIYRKLRGTLRYLLGNLHDWK-PDNAVP 694
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 691 VEEWLDIDHYALALTRRLQEQVTGDYARFEFHKIVQALQNFAAEDLGAFYVDILKDRLYTTKADSRARRAAQTALWHITQ 770
Cdd:PLN02843 695 YEDLPSIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLYVGGTTSFTRRSCQTVLAAHLL 774
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 771 AITRMMAPILTFTAEEIW-----RVTGNDAEdSVMLHTWHELPE--LGASDEILARWELIRSARAEVQKVLESLRSDGRI 843
Cdd:PLN02843 775 SLLRAIAPILPHLAEDAWqnlpfQEDGSAAE-SVFEAGWPTPNEewLSFPAEDVDFWSLLLEVRDEVNKVLESARNGKLI 853
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 844 GASLQAEVRVRASGARFDAL------ASVGAD-LHFVLITSRAELVRVETEADEG----------------VDAAPSSHQ 900
Cdd:PLN02843 854 GASLEAKVYLHASDASLAARlaelcgASNGADeLRRIFITSQVEVVSSEDDETAAcgsytgeyvegagrvwVGVSRADGS 933
|
970 980
....*....|....*....|....*
gi 81821070 901 KCGRCWHFREDIGVDADHPELCGRC 925
Cdd:PLN02843 934 KCERCWNYSPAVGSFSDHPTLCERC 958
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
27-654 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 682.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 27 GWVADWQAKKLYQKVRKAAAGRPKFVLHDGPPYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDCHGLPIEHQI 106
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 107 EKQHGKHLPADRA-------RELCREYAAEQIERQKKDFIRLGVLGDWDNPYRTMNFSNEADEIRALGELFRKGFLFKGL 179
Cdd:pfam00133 81 EKKLGIKEKKTRHkygreefREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 180 KPVNWCFDCGSALAEAEVEYQDKKSPAIDVGFPLVDNERdklahafgldtlpeqpVYIVIWTTTPWTIPSNQALNVHPEL 259
Cdd:pfam00133 161 KLVNWSPALNTALSNLEVEYKDVKGPSIHVAFPLADDEG----------------ASLVIWTTTPWTLPGNTAVAVNPEF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 260 IYelvETPKGLLILaAELRASALERYQLEGRVLAAARGVALDRINFRHPFYDRLSPVFLGDYVAADAGTGIVHSAPAYGL 339
Cdd:pfam00133 225 DY---VITGEGYIL-AEALLKSLYKKGTDKKILEDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGE 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 340 DDFVSCTRYGMrndEILNPVQADGTFAGSLPFFGGLSVWDANPKIVDKLAEVGSLFASGTLTHSYMHCWRHKTPVIYRAT 419
Cdd:pfam00133 301 NDYEVGQRHNL---EVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRAT 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 420 TQWFVGMDRlpgreavepgsatLRELALKAVDETQFYPAWGKARLHSMIANRPDWCVSRQRNWGVPIPLFLHKETGEPHP 499
Cdd:pfam00133 378 PQWFVRMDE-------------LADQALEAVEKVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVC 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 500 RSlELLEQVAQRVEQHGIDAWFKLDAAELLGSDVAQYDKMRDTLDVWFDSGTTHWTVL----RGSHAADSQWPAALYLEG 575
Cdd:pfam00133 445 RG-ELFELVAGRFEEEGSIKWLHREAKDKLGYGKGTLEQDEDVLDTWFSSGSWPFSTLgwpfVNTEEFKKFFPADMLLEG 523
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81821070 576 SDQHRGWFHSSLLTGCAIDGRAPYDALLTHGFVVDGQGKKMSKSKGNVVAPQEVSDKLGAEILRLWVAATDYSGELTIS 654
Cdd:pfam00133 524 SDQTRGWFYRMIMLSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSDYGRDINLS 602
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
15-895 |
8.41e-117 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 377.86 E-value: 8.41e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 15 FPMRGDLAKREPGWVADWQAKKLYQKvrKAAAGRPKFVLHDGPPYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPG 94
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKP--DGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 95 WDCHGLPIEHQIEKQHGKH------LPADRARELCREYAAEQIERQKKDFIRLGVLGDWDNPYRTM--NFSNEADEirAL 166
Cdd:TIGR00422 79 TDHAGIATQVKVEKKLGAEgktkhdLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMdeGLSKAVKE--AF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 167 GELFRKGFLFKGLKPVNWCFDCGSALAEAEVEYQDKKSPAIDVGFPLVDNERDklahafgldtlpeqpvYIVIWTTTPWT 246
Cdd:TIGR00422 157 VRLYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLANGSKD----------------YLVVATTRPET 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 247 IPSNQALNVHPELiyelvetpkgllilaaelrasalERYQ-LEGRVlaaargvaldrinFRHPFYDRLSPVFLGDYVAAD 325
Cdd:TIGR00422 221 MFGDTAVAVHPED-----------------------ERYKhLIGKK-------------VILPLTGRKIPIIADEYVDME 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 326 AGTGIVHSAPAYGLDDFVSCTRYGMrndEILNPVQADGTFAGSLPFFGGLSVWDANPKIVDKLAEVGSLFASGTLTHSYM 405
Cdd:TIGR00422 265 FGTGAVKVTPAHDFNDYEWGKRHNL---EFINILDEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVG 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 406 HCWRHKTPVIYRATTQWFVGMDRL--PGREAVEPGSAtlrelalkavdetQFYPAWGKARLHSMIANRPDWCVSRQRNWG 483
Cdd:TIGR00422 342 TCWRSGTVVEPLLSKQWFVKVEKLadKALEAAEEGEI-------------KFVPKRMEKRYLNWLRNIKDWCISRQLIWG 408
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 484 VPIPLFLHKETGEPHPRSLELLEqvaqrveqhgidawfklDAAELLGSDVaQYDKMRDTLDVWFDSGTTHWTVLrGSHAA 563
Cdd:TIGR00422 409 HRIPVWYCKECGEVYVAKEEPLP-----------------DDKTNTGPSV-ELEQDTDVLDTWFSSSLWPFSTL-GWPDE 469
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 564 DSQ----WPAALYLEGSDQHRGWFHSSLLTGCAIDGRAPYDALLTHGFVVDGQGKKMSKSKGNVVAPQEVSDKLGAEILR 639
Cdd:TIGR00422 470 TKDlkkfYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALR 549
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 640 LWVAATDYSGElTISKEILDrvVEVYRRLRNTL----RFLLAN-TGDFDIARDGVPVEewlDIDHYALALTRRLQEQVTG 714
Cdd:TIGR00422 550 FTLASLVTPGD-DINFDWKR--VESARNFLNKLwnasRFVLMNlSDDLELSGGEEKLS---LADRWILSKLNRTIKEVRK 623
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 715 DYARFEFHKIVQALQNFAAEDLGAFYVDILKDRLYTTKADsrARRAAQTALWHITQAITRMMAPILTFTAEEIWRVTGND 794
Cdd:TIGR00422 624 ALDKYRFAEAAKALYEFIWNDFCDWYIELVKYRLYNGNEA--EKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEG 701
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 795 AeDSVMLHTWHELPELGASDEILARWELIRSARAEVQKvlesLRSDGRIGASLQAEVRVRASGArfDALASVGADLHFVL 874
Cdd:TIGR00422 702 A-DSIMLQSYPVVDAEFVDEEAEKAFELLKEIIVSIRN----LKAESNIPPNAPLKVLLIYTEA--ETAERLKLNAVDIK 774
|
890 900
....*....|....*....|.
gi 81821070 875 ITSRAELVRVETEADEGVDAA 895
Cdd:TIGR00422 775 GAINFSEVEVVIEKPEVTEAV 795
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
20-838 |
2.91e-113 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 375.22 E-value: 2.91e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 20 DLAKREPGWVADWQAKKLYQKVRKAAAGRPKFVLHDGPPYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDCHG 99
Cdd:PLN02882 9 SFPKQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 100 LPIEHQIEKQHG-KH------LPADRARELCREYAAEQIERQKKDFIRLGVLGDWDNPYRTMNFSNEADEIRALGELFRK 172
Cdd:PLN02882 89 LPVEYEIDKKLGiKRrddvlkMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEK 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 173 GFLFKGLKPVNWCFDCGSALA--EAEVEYQDKKSPAIDVGFPLVDnerDKLAHAFgldtlpeqpvyiVIWTTTPWTIPSN 250
Cdd:PLN02882 169 GLVYKGFKVMPYSTACKTPLSnfEAGLNYKDVSDPAVMVSFPIVG---DPDNASF------------VAWTTTPWTLPSN 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 251 QALNVHPELIYELVETP-KGLLILAAELRASAL-----------------ERYQlegrVLAAARGVALDRINFR--HPFY 310
Cdd:PLN02882 234 LALCVNPNFTYVKVRNKyTGKVYIVAESRLSALptakpkskkgskpenaaEGYE----VLAKVPGSSLVGKKYEplFDYF 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 311 DRLSP----VFLGDYVAADAGTGIVHSAPAYGLDDFVSCTRYGM--RNDEILNPVQADGTFAGSLPFFGGLSVWDANPKI 384
Cdd:PLN02882 310 SEFSDtafrVVADDYVTDDSGTGVVHCAPAFGEDDYRVCLANGIieKGGNLPVPVDDDGCFTEKVTDFSGRYVKDADKDI 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 385 VDKLAEVGSLFASGTLTHSYMHCWRHKTPVIYRATTQWFVgmdrlpgreAVEpgsaTLRELALKAVDETQFYPAWGK-AR 463
Cdd:PLN02882 390 IAAIKAKGRLVKSGSITHSYPFCWRSDTPLIYRAVPSWFV---------KVE----EIKDRLLENNKQTYWVPDYVKeKR 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 464 LHSMIANRPDWCVSRQRNWGVPIPLFLhKETGEPHP--RSLELLEQ----VAQRVEQHGIDawfKLDAAELLGSDVAQYD 537
Cdd:PLN02882 457 FHNWLENARDWAVSRSRFWGTPLPIWI-SDDGEEVVviGSIAELEKlsgvKVTDLHRHFID---HITIPSSRGPEFGVLR 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 538 KMRDTLDVWFDSGT-----THWTvLRGSHAADSQWPAALYLEGSDQHRGWFHSSLLTGCAIDGRAPYDALLTHGFVVDGQ 612
Cdd:PLN02882 533 RVDDVFDCWFESGSmpyayIHYP-FENKELFEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAED 611
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 613 GKKMSKSKGNVVAPQEVSDKLGAEILRLW------VAATdysgELTISKE-ILDRVVEVYRRLRNTLRFLLANT------ 679
Cdd:PLN02882 612 GKKMSKSLKNYPDPNEVIDKYGADALRLYlinspvVRAE----PLRFKEEgVFGVVKDVFLPWYNAYRFLVQNAkrleve 687
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 680 -------GDFDIARDGVPVeewldIDHYALALTRRLQEQVTGDYARFEFHKIVQALQNFaAEDLGAFYVDILKDRLYTTK 752
Cdd:PLN02882 688 ggapfvpLDLAKLQNSANV-----LDRWINSATQSLVKFVREEMGAYRLYTVVPYLVKF-IDNLTNIYVRFNRKRLKGRT 761
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 753 ADSRARRAAQTaLWHITQAITRMMAPILTFTAEEIW---RVTGNDAEDSVmlHtWHELPELGASdeilARWELIRSARAE 829
Cdd:PLN02882 762 GEEDCRTALST-LYNVLLTSCKVMAPFTPFFTEVLYqnlRKVLPGSEESI--H-YCSFPQVDEG----ELDERIEQSVSR 833
|
....*....
gi 81821070 830 VQKVLESLR 838
Cdd:PLN02882 834 MQTVIELAR 842
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
10-892 |
7.55e-111 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 360.28 E-value: 7.55e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 10 MPDTPFPMRGDLAKREPGWVADWQAKKLYQKVRkaAAGRPKFVLHDGPPYANGDIHIGHAVNKILKDIIVRSKTLAGFDA 89
Cdd:PRK13208 1 KMMPELPKKYDPEELEEKWQKIWEEEGTYKFDP--DERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 90 PYVPGWDCHGLPIEHQIEKQHG-KHLPADRA--RELCREYAAEQIERQKKDFIRLGVLGDWDNPYRTMnfSNEADEI--R 164
Cdd:PRK13208 79 FFPQGWDDNGLPTERKVEKYYGiRKDDISREefIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTI--SPEYRRIsqK 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 165 ALGELFRKGFLFKGLKPVNWCFDCGSALAEAEVEYQDKKSPAIDVGFPLVDNErdklahafgldtlpeqpvYIVIWTTTP 244
Cdd:PRK13208 157 SFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGKLNYIKFPVEDGE------------------EIEIATTRP 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 245 WTIPSNQALNVHPELiyelvetpkgllilaaelrasalERYQ-LEGRvlaaargvaldriNFRHPFYDRLSPVFLGDYVA 323
Cdd:PRK13208 219 ELLPACVAVVVHPDD-----------------------ERYKhLVGK-------------TAIVPLFGVEVPILADPLVD 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 324 ADAGTGIVhsapayglddfVSCTrYGMRNDEI------LNPVQA---DGTFAGSLPFFGGLSVWDANPKIVDKLAEVGSL 394
Cdd:PRK13208 263 PDFGTGAV-----------MICT-FGDKTDVTwwrelnLPTRIIideDGRMTEAAGKLAGLTIEEARKKIVEDLKSGGLL 330
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 395 FASGTLTHSYMHCWRHKTPVIYRATTQWFVGMdrlpgreavepgsATLRELALKAVDETQFYPAWGKARL----HSMian 470
Cdd:PRK13208 331 GKQEPIKHNVKFCERCDTPLEILVTRQWFIKV-------------LDLKEELLERGKEINWYPEHMRVRLenwiEGL--- 394
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 471 RPDWCVSRQRNWGVPIPLFLHKETGEPHprslelleqVAqRVEQHGIDAWF---KLDAAELLGSDVAQYDKmrDTLDVWF 547
Cdd:PRK13208 395 NWDWCISRQRYFGTPIPVWYCKDCGHPI---------LP-DEEDLPVDPTKdepPGYKCPQCGSPGFEGET--DVMDTWA 462
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 548 DSGTT-----HWtvLRGSHAADSQWPAALYLEGSDQHRGWFHSSLLTGCAIDGRAPYDALLTHGFVVDGQGKKMSKSKGN 622
Cdd:PRK13208 463 TSSITplivtGW--ERDEDLFEKVFPMDLRPQGHDIIRTWLFYTILRAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGN 540
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 623 VVAPQEVSDKLGAEILRLWvAATDYSGELTISKEildRVVEVYRRLRNTL----RFLLAntgdFDIARDGVPVEEWLDID 698
Cdd:PRK13208 541 VVTPEELLEKYGADAVRYW-AASARLGSDTPFDE---KQVKIGRRLLTKLwnasRFVLH----FSADPEPDKAEVLEPLD 612
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 699 HYALALTRRLQEQVTGDYARFEFHKIVQALQNFAAEDLGAFYVDILKDRLYtTKADSRARRAAQTALWHITQAITRMMAP 778
Cdd:PRK13208 613 RWILAKLAKVVEKATEALENYDFAKALEEIESFFWHVFCDDYLELVKSRAY-GEDEEEEQKSARYTLYTVLDTLLRLLAP 691
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 779 ILTFTAEEIWRVTGndaEDSVMLHTWHELPELGASDEILARWELIRSARAEVQKVleslRSDGRIgaSLQAEV-RVRASG 857
Cdd:PRK13208 692 FLPFITEEVWSWLY---GGSVHRASWPEPDEELIDEEDEELGELAKEILSAVRKY----KSEAGL--SLNAPLkKVEVYG 762
|
890 900 910
....*....|....*....|....*....|....*.
gi 81821070 858 -ARFDALASVGADLHFVLITSRAELVRVETEADEGV 892
Cdd:PRK13208 763 pADLELLEAAEEDLKAAGNIEELELVEGDPELEVEI 798
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
49-650 |
1.22e-101 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 320.72 E-value: 1.22e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 49 PKFVLHDGPPYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDCHGLPIEHQIEKQHGkhlpadrarelcreyaa 128
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELG----------------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 129 eqiERQKKDFIRLGVLgdwdnpyrtmNFSNEADEIralgelfrkgflfkglkpvnwcfdcgsALAeaeveyqdkkspaid 208
Cdd:cd00818 64 ---ISGKKDIEKMGIA----------EFNAKCREF---------------------------ALR--------------- 88
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 209 vgfplvdnerdklahafgldtlpeqpvYIVIWTttpwtipsnqalnvhpeliyelvetpkgllilaaelraSALERYqle 288
Cdd:cd00818 89 ---------------------------YVDEQE--------------------------------------EQFQRL--- 100
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 289 grvlaaarGVALDrinFRHPfYDRLSPvflgDYVAadagtgivhsapayglddfvsctrygmrndeilnpvqadgtfags 368
Cdd:cd00818 101 --------GVWVD---WENP-YKTMDP----EYME--------------------------------------------- 119
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 369 lpffgglSVWDAnpkivdklaeVGSLFASGTLTHSY--MHcWrhktPVIYRATTQWFVGMDrlpgreavepgsaTLRELA 446
Cdd:cd00818 120 -------SVWWV----------FKQLHEKGLLYRGYkvVP-W----PLIYRATPQWFIRVT-------------KIKDRL 164
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 447 LKAVDETQFYPAWGKARLHSMIANRPDWCVSRQRNWGVPIPLFLHKETGEPHPRslelleqvaqRVEqhgidawfkldaa 526
Cdd:cd00818 165 LEANDKVNWIPEWVKNRFGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEVLVR----------RVP------------- 221
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 527 ellgsdvaqydkmrDTLDVWFDSGTTHWTVL---RGSHAADSQWPAALYLEGSDQHRGWFHSSLLTGCAIDGRAPYDALL 603
Cdd:cd00818 222 --------------DVLDVWFDSGSMPYAQLhypFENEDFEELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVI 287
|
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 81821070 604 THGFVVDGQGKKMSKSKGNVVAPQEVSDKLGAEILRLWVAATDYSGE 650
Cdd:cd00818 288 VHGFVLDEDGRKMSKSLGNYVDPQEVVDKYGADALRLWVASSDVYAE 334
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
32-789 |
1.30e-89 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 310.36 E-value: 1.30e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 32 WQAKKLYQKVRKAAAGRPKFVLHDGPPYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDCHGLPIEHQIEKQHG 111
Cdd:PTZ00427 85 WKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIEYEIEKENN 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 112 KH-------LPADRARELCREYAAEQIERQKKDFIRLGVLGDWDNPYRTMNFSNEADEIRALGELFRKGFLFKGLKPVNW 184
Cdd:PTZ00427 165 INkkedilkMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYKSFKVMPY 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 185 CFDCGSALA--EAEVEYQDKKSPAIDVGF------PLVDNE------RDKLAHAFGL------------------DTLPE 232
Cdd:PTZ00427 245 SCKCNTPISnfELNLNYKDTPDPSIIISFvlcsdfPKVEEEcnieedKQLLGEKYSVlynnkrensnngnnnstnNVCYA 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 233 QPVYIVIWTTTPWTIPSNQALNVHPELIYELVETPKG-LLILAAELRasaLE------RYQLEG-RVLAAARGVALDRIN 304
Cdd:PTZ00427 325 QHSEILAWTTTPWTLPSNLALCVNEHFTYLRIHHVKSnRVVIVGECR---LEwimkelKWNVEDlKIVNRFKGKELKGLR 401
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 305 FR---------HPFYDRLSPVFLGDYVAADAGTGIVHSAPAYGLDDFVSCTRYGMRNDE---ILNPVQADGTFAGSLPFF 372
Cdd:PTZ00427 402 YKplftnfyekYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVIDPEkniFIDPLDANGYFTNEVEEV 481
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 373 GGLSVWDANPKIVDKLAEVGSLFASGTLTHSYMHCWRHKTPVIYRATTQWFVGMdrlpgreavepgSATLRELaLKAVDE 452
Cdd:PTZ00427 482 QNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRV------------SNSTNEL-VKNNET 548
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 453 TQFYPAWGK-ARLHSMIANRPDWCVSRQRNWGVPIPLFL-HKETGEPHPRSLELLEQVA-----QRVEQHGIDawfKLDA 525
Cdd:PTZ00427 549 TYWIPAHIKeKKFHNWIKDAKDWCISRNRYWGTPIPIWAdEKMETVICVESIKHLEELSgvkniNDLHRHFID---HIEI 625
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 526 AELLGSDVAQYDKMRDTLDVWFDSGT-----THWTVLRGSHAADSQWPAALYLEGSDQHRGWFHSSLLTGCAIDGRAPYD 600
Cdd:PTZ00427 626 KNPKGKTYPKLKRIPEVFDCWFESGSmpyakVHYPFSTEKEDFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFK 705
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 601 ALLTHGFVVDGQGKKMSKSKGNVVAPQEVSDKLGAEILRLWV--AATDYSGELTISKEILDRVVE-----VYRRLR---- 669
Cdd:PTZ00427 706 NLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLinSVAVRAENLKFQEKGVNEVVKsfilpFYHSFRffsq 785
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 670 NTLRFLLANTGDFDIARDGVPVEEWLdIDHYALALTRRLQEQVTGDYARFEFHKIVQALQNFaAEDLGAFYVDILKDRLY 749
Cdd:PTZ00427 786 EVTRYECLNKKQFLFNTDYIYKNDNI-MDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQF-IENLTNWYIRLNRDRMR 863
|
810 820 830 840
....*....|....*....|....*....|....*....|
gi 81821070 750 TTKADSRARRAAQTaLWHITQAITRMMAPILTFTAEEIWR 789
Cdd:PTZ00427 864 GSLGEENCLQSLCT-TYRTLHLFTVLMAPFTPFITEYIYQ 902
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
653-830 |
3.91e-82 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 262.85 E-value: 3.91e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 653 ISKEILDRVVEVYRRLRNTLRFLLANTGDFDIARDGVPVEEWLDIDHYALALTRRLQEQVTGDYARFEFHKIVQALQNFA 732
Cdd:cd07960 1 ISDEILKQVAEAYRKIRNTFRFLLGNLNDFDPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 733 AEDLGAFYVDILKDRLYTTKADSRARRAAQTALWHITQAITRMMAPILTFTAEEIWR-VTGNDAEDSVMLHTWHELPELG 811
Cdd:cd07960 81 TVDLSAFYLDIIKDRLYCDAKDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEhLPGEKKEESVFLEDWPELPEEW 160
|
170
....*....|....*....
gi 81821070 812 ASDEILARWELIRSARAEV 830
Cdd:cd07960 161 KDEELEEKWEKLLALRDEV 179
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
14-859 |
3.25e-75 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 267.24 E-value: 3.25e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 14 PFPM----RGDLAKR------EPGWVADWQAKKlYQKVRKAAAGRPKFVLHDGPPYANGDIHIGHAVNKILKDIIVRSKT 83
Cdd:PRK14900 4 PNPIenenRTELAKGyehrevEARWYPFWQERG-YFHGDEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 84 LAGFDAPYVPGWDCHGLPIEHQIEKQHGKHLPADRaRELCREYAAEQIERQKKDF-IRLG----VLG---DWDNPYRTMN 155
Cdd:PRK14900 83 MSGFNTLWLPGTDHAGIATQMIVEKELKKTEKKSR-HDLGREAFLERVWAWKEQYgSRIGeqhkALGaslDWQRERFTMD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 156 FSNEADEIRALGELFRKGFLFKGLKPVNWCFDCGSALAEAEVEYQDKKSPAI-DVGFPLVDNERDklahafgldtlpeqp 234
Cdd:PRK14900 162 EGLSRAVREVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAHQGELwSFAYPLADGSGE--------------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 235 vyIVIWTTTPWTIPSNQALNVHPELiyelvetpkgllilaaelrasalERYQ-LEGRvlaaargvaldriNFRHPFYDRL 313
Cdd:PRK14900 227 --IVVATTRPETMLGDTAVAVHPLD-----------------------PRYMaLHGK-------------KVRHPITGRT 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 314 SPVfLGDYVAADA--GTGIVHSAPAYGLDDFVSCTRYGMRNDEILNPvqaDGTFAGSLPFFGGLSVWDANPKIVDKLAEV 391
Cdd:PRK14900 269 FPI-VADAILVDPkfGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGP---DGRMTAEAGPLAGLDRFEARKEVKRLLAEQ 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 392 GSLfaSGTLTH--SYMHCWRHKTPVIYRATTQWFVGMDRL--PGREAVEPGsatlrelalkavdETQFYP-AWGKARLHS 466
Cdd:PRK14900 345 GLD--RGAKPHvlPLGRCQRSATILEPLLSDQWYVRIEPLarPAIEAVEQG-------------RTRFIPeQWTNTYMAW 409
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 467 MiANRPDWCVSRQRNWGVPIPLFlHKETGEPhprslelleqvaqRVEQHGIDAWFKLDAAELLGSDvaqydkmrDTLDVW 546
Cdd:PRK14900 410 M-RNIHDWCISRQLWWGHQIPAW-YCPDGHV-------------TVARETPEACSTCGKAELRQDE--------DVLDTW 466
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 547 FDSGTTHWTVL---RGSHAADSQWPAALYLEGSDQHRGWFHSSLLTGCAIDGRAPYDALLTHGFVVDGQGKKMSKSKGNV 623
Cdd:PRK14900 467 FSSGLWPFSTMgwpEQTDTLRTFYPTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNV 546
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 624 VAPQEVSDKLGAEILRLWVAATDYSG-ELTISKEILDRVVEVYRRLRNTLRFLLANTGDFDIarDGVPVEE--WLDIDHY 700
Cdd:PRK14900 547 IDPLVITEQYGADALRFTLAALTAQGrDIKLAKERIEGYRAFANKLWNASRFALMNLSGYQE--RGEDPARlaRTPADRW 624
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 701 ALALTRRLQEQVTGDYARFEFHKIVQALQNFAAEDLGAFYVDILKDRLYTTkaDSRARRAAQTALWHITQAITRMMAPIL 780
Cdd:PRK14900 625 ILARLQRAVNETVEALEAFRFNDAANAVYAFVWHELCDWYIELAKEALASE--DPEARRSVQAVLVHCLQTSYRLLHPFM 702
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 781 TFTAEEIW-----RVTGNDAEDSVMLHTWhelPELGASDE--------ILARWELIRSARAEVqkvleSLRSDGRIGASL 847
Cdd:PRK14900 703 PFITEELWhvlraQVGASAWADSVLAAEY---PRKGEADEaaeaafrpVLGIIDAVRNIRGEM-----GIPWKVKLGAQA 774
|
890
....*....|..
gi 81821070 848 QAEVRVRASGAR 859
Cdd:PRK14900 775 PVEIAVADPALR 786
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
25-898 |
6.64e-69 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 246.56 E-value: 6.64e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 25 EPGWVADWQAKKLYqkvrKAAAgrpkfvlHDGPPYA------N--GDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWD 96
Cdd:PRK05729 15 EAKWYQKWEEKGYF----KPDD-------NSKKPFSivipppNvtGSLHMGHALNNTLQDILIRYKRMQGYNTLWLPGTD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 97 cH-GLPIEHQIEKQ---HGKhlpaDRaRELCRE--------YAAEQ---IERQKKdfiRLGVLGDWDNPYRTMnfsneaD 161
Cdd:PRK05729 84 -HaGIATQMVVERQlaaEGK----SR-HDLGREkflekvweWKEESggtITNQLR---RLGASCDWSRERFTM------D 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 162 E------IRALGELFRKGFLFKGLKPVNWCFDCGSALAEAEVEYQDKKspaidvGF------PLVDNERdklahafgldt 229
Cdd:PRK05729 149 EglskavREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVK------GKlwhiryPLADGSD----------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 230 lpeqpvYIVIWTTTPWTIPSNQALNVHPELiyelvetpkgllilaaelrasalERYQ-LEGRvlaaargvaldriNFRHP 308
Cdd:PRK05729 212 ------YLVVATTRPETMLGDTAVAVNPED-----------------------ERYKhLIGK-------------TVILP 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 309 FYDRLSPVFLGDYVAADAGTGIVHSAPAYGLDDF-VsctryGMRND----EILNPvqaDGTFAGSLPFFGGLSVWDANPK 383
Cdd:PRK05729 250 LVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFeV-----GKRHNlpmiNIMDE---DGTINENPGEYQGLDRFEARKA 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 384 IVDKLAEVGSLFASGTLTHSYMHCWRHKTPVIYRATTQWFVGMDrlpgreavepgsaTLRELALKAV--DETQFYPA-WG 460
Cdd:PRK05729 322 IVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMK-------------PLAKPALEAVenGEIKFVPErWE 388
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 461 KARLHSMiANRPDWCVSRQRNWGVPIPLFLHKETG------EPHPRSLELLEQvaqrveqhgidawfkldaaellgsdva 534
Cdd:PRK05729 389 KTYFHWM-ENIQDWCISRQLWWGHRIPAWYDEDGEvyvgreEPEAREKALLTQ--------------------------- 440
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 535 qyDKmrDTLDVWFDSGtthwtvLrgshaadsqWP-AALylegsdqhrGW---------FH--SSLLTG------------ 590
Cdd:PRK05729 441 --DE--DVLDTWFSSA------L---------WPfSTL---------GWpektedlkrFYptSVLVTGfdiiffwvarmi 492
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 591 ---CAIDGRAPYDALLTHGFVVDGQGKKMSKSKGNVVAPQEVSDKLGAEILRLWVAA-------TDYSgeltiskeiLDR 660
Cdd:PRK05729 493 mmgLHFTGQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAAlaspgrdIRFD---------EER 563
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 661 vVEVYRRLRNTL----RFLLANTGDFDIARDGvPVEEWLDIDHYALALTRRLQEQVTGDYARFEFHKIVQALQNFAAEDL 736
Cdd:PRK05729 564 -VEGYRNFANKLwnasRFVLMNLEGADVGELP-DPEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIWNEF 641
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 737 GAFYVDILKDRLYTTkadsrARRAAQTALWHITQAITRMMAPILTFTAEEIW-RVTGNDAEDSVMLHTWhelPELGAS-- 813
Cdd:PRK05729 642 CDWYLELAKPVLQEA-----AKRATRATLAYVLEQILRLLHPFMPFITEELWqKLAPLGIEESIMLAPW---PEADEAid 713
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 814 DEILARWEL-------IRSARAEVQkvleslrsdgrIGASLQAEVRVRASGA----RFDALASVGADLhfvlitSRAELV 882
Cdd:PRK05729 714 EAAEAEFEWlkelitaIRNIRAEMN-----------IPPSKKLPLLLKGADAedraRLEANEAYIKRL------ARLESL 776
|
970
....*....|....*.
gi 81821070 883 RVETEADEGVDAAPSS 898
Cdd:PRK05729 777 EILADDEEAPEGAASA 792
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
25-897 |
4.67e-66 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 238.41 E-value: 4.67e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 25 EPGWVADWQAKKLYQkvRKAAAGRPKF--VLhdGPPYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDcH-Glp 101
Cdd:COG0525 13 EAKWYQYWEENGYFK--ADPDSDKEPFtiVI--PPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPGTD-HaG-- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 102 I------EHQIEKQhGKhlpaDRaRELCRE----YAAE-------QIERQKKdfiRLGVLGDWDNPYRTMnfsneaDE-- 162
Cdd:COG0525 86 IatqavvERQLAEE-GK----SR-HDLGREkfleRVWEwkeesggTITNQLR---RLGASCDWSRERFTM------DEgl 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 163 ----IRALGELFRKGFLFKGLKPVNWCFDCGSALAEAEVEYQDKKspaidvGF------PLVDNERdklahafgldtlpe 232
Cdd:COG0525 151 skavREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVK------GHlwhiryPLADGSG-------------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 233 qpvYIVIWTTTPWTIPSNQALNVHPEliyelvetpkgllilaaelrasaLERYQ-LEGRVLaaargvaldrinfRHPFYD 311
Cdd:COG0525 211 ---YIVVATTRPETMLGDTAVAVHPE-----------------------DERYKhLIGKTV-------------ILPLVG 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 312 RLSPVFLGDYVAADAGTGIVHSAPAYGLDDF-VsctryGMRND----EILNPvqaDGTFAGSLPFFGGLSVWDANPKIVD 386
Cdd:COG0525 252 REIPIIADEYVDPEFGTGAVKITPAHDPNDFeV-----GKRHNlpmiNILDE---DGTINENAGKYRGLDRFEARKAIVA 323
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 387 KLAEVGSLFASGTLTHSYMHCWRHKTPVIYRATTQWFVGMDRLpgreaVEPgsatlrelALKAV--DETQFYPA-WGKAR 463
Cdd:COG0525 324 DLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPL-----AKP--------AIEAVedGEIKFVPErWEKTY 390
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 464 LHSMiANRPDWCVSRQRNWGVPIPLFLHKEtGEPHprslelleqvaqrVEQHGIDAWFKLDAAELlgsdvaQYDKmrDTL 543
Cdd:COG0525 391 FHWM-ENIRDWCISRQLWWGHRIPAWYCPD-GEVY-------------VARTEPEACAKAGSVNL------TQDE--DVL 447
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 544 DVWFDSGtthwtvLrgshaadsqWP-AALylegsdqhrGW---------FH--SSLLTG---------------CAIDGR 596
Cdd:COG0525 448 DTWFSSA------L---------WPfSTL---------GWpektedlkyFYptSVLVTGfdiiffwvarmimmgLHFTGE 503
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 597 APYDALLTHGFVVDGQGKKMSKSKGNVVAPQEVSDKLGAEILRLWVAAtdysgELTISKEI---LDRvVEVYRR----LR 669
Cdd:COG0525 504 VPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAA-----LASPGRDIkfdEER-VEGYRNfankLW 577
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 670 NTLRFLLANTGDFDIARDGVPvEEWLDIDHYALALTRRLQEQVTGDYARFEFHKIVQALQNFAAEDLGAFYVDILKDRLY 749
Cdd:COG0525 578 NASRFVLMNLEGFDPGLDPDP-EELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVWNEFCDWYLELAKPRLY 656
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 750 ttKADSRARRAAQTALWHITQAITRMMAPILTFTAEEIW-RVTGNDAEDSVMLHTWHELPELGASDEILARWEL------ 822
Cdd:COG0525 657 --GGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWqKLPPRKEGESIMLAPWPEADEELIDEEAEAEFEWlkevis 734
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81821070 823 -IRSARAEVQkvleslrsdgrIGASLQAEVRVRASGARFDALASVGADlhfvLITSRAELVRVETEADEGVDAAPS 897
Cdd:COG0525 735 aIRNIRAEMN-----------IPPSKKLPLLLKGADEADRARLEENAA----YIKRLARLEEITILVDEKPEGAAS 795
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
31-853 |
2.47e-52 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 198.63 E-value: 2.47e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 31 DWQAKKLYQKVRKAAAGRPkFVLHDGPPYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDCHGLPIEHQIEKQh 110
Cdd:PLN02943 71 NWWESQGYFKPNFDRGGDP-FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLVVEKM- 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 111 gkhLPAD--RARELCREYAAEQIERQKKDF--------IRLGVLGDWDNPYRTMNFSNEADEIRALGELFRKGFLFKGLK 180
Cdd:PLN02943 149 ---LASEgiKRTDLGRDEFTKRVWEWKEKYggtitnqiKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSY 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 181 PVNWCFDCGSALAEAEVEYQDKKSPAIDVGFPLVDNERDklahafgldtlpeqpvYIVIWTTTPWTIPSNQALNVHPELi 260
Cdd:PLN02943 226 MVNWSPNLQTAVSDLEVEYSEEPGTLYYIKYRVAGGSED----------------FLTIATTRPETLFGDVAIAVNPED- 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 261 yelvetpkgllilaaelrasalERYQlegRVLAAARGVALDrinfrhpfYDRLSPVFLGDYVAADAGTGIVHSAPAYGLD 340
Cdd:PLN02943 289 ----------------------DRYS---KYIGKMAIVPMT--------YGRHVPIIADRYVDKDFGTGVLKISPGHDHN 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 341 DFVSCTRYGMrndEILNPVQADGTfagsLPFFGGLSVWDANPKIVDKLAEVGSLFASGTLTHSYMHCWRHKTPVIYRATT 420
Cdd:PLN02943 336 DYLLARKLGL---PILNVMNKDGT----LNEVAGLYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSK 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 421 QWFVGMDRLPGR--EAVEPGsatlrELALKAVDETQFYPAWgkarlhsmIANRPDWCVSRQRNWGVPIPLF--LHKETGE 496
Cdd:PLN02943 409 QWFVTMEPLAEKalKAVENG-----ELTIIPERFEKIYNHW--------LSNIKDWCISRQLWWGHRIPVWyiVGKDCEE 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 497 phprslellEQVAQRVEQHGIDAwfkldAAELLGSDVAQYDKmRDTLDVWFDSGTTHWTVL--RGSHAADSQ--WPAALY 572
Cdd:PLN02943 476 ---------DYIVARSAEEALEK-----AREKYGKDVEIYQD-PDVLDTWFSSALWPFSTLgwPDVSAEDFKkfYPTTVL 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 573 LEGSDQHRGWFHSSLLTGCAIDGRAPYDALLTHGFVVDGQGKKMSKSKGNVVAPQEVSDKLGAEILRLWVAATDYSGELT 652
Cdd:PLN02943 541 ETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLALGTAGQDLN 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 653 ISKEILDRVVEVYRRLRNTLRFLLANTGDF-DIARDGVPVEEWLDIDHYALALT----------RRLQEQVTGDYARFEF 721
Cdd:PLN02943 621 LSTERLTSNKAFTNKLWNAGKFVLQNLPSQsDTSAWEHILACKFDKEESLLSLPlpecwvvsklHELIDSVTTSYDKYFF 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 722 HKIVQALQNFAAEDLGAFYVDILKDRLYTTKADSrARRAAQTALWHITQAITRMMAPILTFTAEEIWRVTGNDAEdSVML 801
Cdd:PLN02943 701 GDVGREIYDFFWSDFADWYIEASKTRLYHSGDNS-ALSRAQAVLLYVFENILKLLHPFMPFVTEELWQALPYRKE-ALIV 778
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*...
gi 81821070 802 HTWHE--LPELGAS----DEILARWELIRSARAEVqkvleSLRSDGRIGASLQAEVRV 853
Cdd:PLN02943 779 SPWPQtsLPKDLKSikrfENLQSLTRAIRNARAEY-----SVEPAKRISASIVASAEV 831
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
25-788 |
6.93e-52 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 197.54 E-value: 6.93e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 25 EPGWVADWQAKKLYQKVRKAAA--GRPKFVLHDGPPYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDCHGLP- 101
Cdd:PTZ00419 34 ESGWYEWWEKSGFFKPAEDAKSlnSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIAt 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 102 ---IEHQIEKQHGK--HlpaDRARE--LCR------EYAAeQIERQKKdfiRLGVLGDWDNPYRTMNFSNEADEIRALGE 168
Cdd:PTZ00419 114 qvvVEKKLMKEENKtrH---DLGREefLKKvwewkdKHGN-NICNQLR---RLGSSLDWSREVFTMDEQRSKAVKEAFVR 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 169 LFRKGFLFKGLKPVNWCFDCGSALAEAEVEYQDKKSPA----------IDVG------FPLVDNErdklahafgldtlpe 232
Cdd:PTZ00419 187 LYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTkitipgydkkVEVGvlwhfaYPLEDSG--------------- 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 233 qPVYIVIWTTTPWTIPSNQALNVHPELiyelvetpkgllilaaelrasalERYQ-LEGRVLaaargvaldrinfRHPFY- 310
Cdd:PTZ00419 252 -QEEIVVATTRIETMLGDVAVAVHPKD-----------------------ERYKkLHGKEL-------------IHPFIp 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 311 DRLSPVFLGD-YVAADAGTGIVHSAPAYGLDDFVSCTRYGMrndEILNPVQADGTFAGSLPFFGGLSVWDANPKIVDKLA 389
Cdd:PTZ00419 295 DRKIPIIADDeLVDMEFGTGAVKITPAHDPNDYEIAKRHNL---PFINIFTLDGKINENGGEFAGMHRFDCRRKIEEELK 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 390 EVGSLfaSGTLTHSYM--HCWRHKTPVIYRATTQWFVGMDRLPGR--EAVEPGSATLrelalkavdetqfYPAWGKARLH 465
Cdd:PTZ00419 372 EMGLL--RDKVPNPMRlpRCSRSGDIVEPMLIPQWYVNCKDMAKRavEAVRNGELKI-------------IPSSHENVWY 436
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 466 SMIANRPDWCVSRQRNWGVPIPLFLHKETGEPHPRSLEllEQ-VAQRVEQHGIDawfklDAAELLGSDVAQYDKMRDT-- 542
Cdd:PTZ00419 437 HWLENIQDWCISRQLWWGHRIPAYRVISKGPETDPSDE--EPwVVARSEEEALE-----KAKKKFGLSEEDFELEQDEdv 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 543 LDVWFDSGTTHWTVLrgshaadsQWPAalylEGSDQHRgWFHSSLL-TGCAI---------------DGRAPYDALLTHG 606
Cdd:PTZ00419 510 LDTWFSSGLFPFSTL--------GWPD----QTDDLQR-FFPTSLLeTGSDIlffwvarmvmmslhlTDKLPFKTVFLHA 576
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 607 FVVDGQGKKMSKSKGNVVAPQEV---------SDKL----------------------------GAEILRLWVAATDYSG 649
Cdd:PTZ00419 577 MVRDSQGEKMSKSKGNVIDPLEViegislqdlNQKLyegnlpekeikraielqkkefpngipecGTDALRFGLLAYTQQG 656
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 650 ElTISKEIlDRVVEvYR----RLRNTLRFLLANTGDFD-------IARDGVPVEEWldIDHYALALTRRLQEQVTGDYAR 718
Cdd:PTZ00419 657 R-NINLDI-NRVVG-YRhfcnKLWNAVKFALMKLLKDFnlpnstlFKPNNVESLPW--EDKWILHRLNVAIKEVTEGFKE 731
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 719 FEFHKIVQALQNFAAEDLGAFYVDILKDRLYTTKADSRARRAAQTALWHITQAItRMMAPILTFTAEEIW 788
Cdd:PTZ00419 732 YDFSEATQATYNFWLYELCDVYLELIKPRLSKQSDGERKQHAQDVLHTVLDIGL-RLLHPMMPFITEELY 800
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
49-644 |
1.26e-44 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 165.88 E-value: 1.26e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 49 PKFVLHDGPPYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDCHGLPIEHQIEKQHGKH------LPADRAREL 122
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEgktrhdLGREEFLEK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 123 CREYAAEQIERQKKDFIRLGVLGDWDNPYRTMnfSNEADEI--RALGELFRKGFLfkglkpvnwcfdcgsalaeaeveYQ 200
Cdd:cd00817 81 CWEWKEESGGKIREQLKRLGASVDWSREYFTM--DPGLSRAvqEAFVRLYEKGLI-----------------------YR 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 201 DKkspaidvgfplvdnerdklahafgldtlpeqpvYIVIWtttpwtipsnqalnvhpeliyelvetpkgllilaaelras 280
Cdd:cd00817 136 DN---------------------------------RLVNW---------------------------------------- 142
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 281 aleryqlegrvlaaargvaldrinfrhpfydrlspvflgdyvaadagtgivhsapayglddfvsCTRygmrndeiLNPVQ 360
Cdd:cd00817 143 ----------------------------------------------------------------CPK--------LRTAI 150
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 361 ADgtfagslpffgglsvwdanpkivdklAEVgslfasgtlthsymhCWRHKTPVIYRATTQWFVGMDrlpgreavepgsa 440
Cdd:cd00817 151 SD--------------------------IEV---------------CSRSGDVIEPLLKPQWFVKVK------------- 176
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 441 TLRELALKAVDE--TQFYPAWGKARLHSMIANRPDWCVSRQRNWGVPIPLFLHKETGEphprslelleQVAQRVEQHGID 518
Cdd:cd00817 177 DLAKKALEAVKEgdIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAWYCKDGGH----------WVVAREEDEAID 246
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 519 AWFKLDAAELLGSDVAQyDKmrDTLDVWFDSG-----TTHWtvLRGSHAADSQWPAALYLEGSDQHRGWFHSSLLTGCAI 593
Cdd:cd00817 247 KAAPEACVPCGGEELKQ-DE--DVLDTWFSSSlwpfsTLGW--PEETKDLKKFYPTSLLVTGHDIIFFWVARMIMRGLKL 321
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|.
gi 81821070 594 DGRAPYDALLTHGFVVDGQGKKMSKSKGNVVAPQEVSDKLGAEILRLWVAA 644
Cdd:cd00817 322 TGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGYGADALRFTLAS 372
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
11-830 |
5.33e-43 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 170.08 E-value: 5.33e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 11 PDTPFPMRGDLAKR----------EPGWVADWQAKKLYqkVRKAAAGRPKFVLHDGPPYANGDIHIGHAVNKILKDIIVR 80
Cdd:PLN02381 82 PDTPFGQKKRLSSQmakqyspsavEKSWYAWWEKSGYF--GADAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIR 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 81 SKTLAGFDAPYVPGWDCHGLPIEHQIEKQHGKHLPADRaRELCREYAAEQIERQK--------KDFIRLGVLGDWDNPYR 152
Cdd:PLN02381 160 WKRMSGYNALWVPGVDHAGIATQVVVEKKLMRERHLTR-HDIGREEFVSEVWKWKdeyggtilNQLRRLGASLDWSRECF 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 153 TMNFSNEADEIRALGELFRKGFLFKGLKPVNWcfDCG--SALAEAEVEYQDKKSPAIdVGFPLVDNERDklahaFGLDTL 230
Cdd:PLN02381 239 TMDEQRSKAVTEAFVRLYKEGLIYRDIRLVNW--DCTlrTAISDVEVDYIDIKERTL-LKVPGYDKPVE-----FGVLTS 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 231 PEQPV-----YIVIWTTTPWTIPSNQALNVHPEliyelvetpkgllilaaelrasaLERYQ-LEGRVLAaargvaldrin 304
Cdd:PLN02381 311 FAYPLegglgEIVVATTRIETMLGDTAIAIHPD-----------------------DERYKhLHGKFAV----------- 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 305 frHPFYDRLSPVFL-GDYVAADAGTGIVHSAPAYGLDDFVSCTRYgmrNDEILNPVQADG---TFAGSLpfFGGLSVWDA 380
Cdd:PLN02381 357 --HPFNGRKLPIICdAILVDPNFGTGAVKITPAHDPNDFEVGKRH---NLEFINIFTDDGkinSNGGSE--FAGMPRFAA 429
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 381 NPKIVDKLAEVGSLFASGTLTHSYMHCWRHKTPVIYRATTQWFVGMDRLpGREAVEpgSATLRElalkaVDETQFYPAWG 460
Cdd:PLN02381 430 REAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNCSSM-AKQALD--AAIDGE-----NKKLEFIPKQY 501
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 461 KARLHSMIANRPDWCVSRQRNWGVPIPLF-------LHKETGEPHPRslelleQVAQRVEQhgiDAwfKLDAAELLGSDV 533
Cdd:PLN02381 502 LAEWKRWLENIRDWCISRQLWWGHRIPAWyvtleddQLKELGSYNDH------WVVARNES---DA--LLEASQKFPGKK 570
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 534 AQYDKMRDTLDVWFDSGTTHWTVLRGSHAAD---SQWPAALYLEGSDQHRGWFHSSLLTGCAIDGRAPYDALLTHGFVVD 610
Cdd:PLN02381 571 FELSQDPDVLDTWFSSGLFPLSVLGWPDDTDdlkAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRD 650
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 611 GQGKKMSKSKGNVVAPQEVSDKLGAEIL--RLWVAATDySGELTISKE-------------------------------- 656
Cdd:PLN02381 651 AHGRKMSKSLGNVIDPLEVINGISLEGLhkRLEEGNLD-PKELVVAKEgqkkdfpngiaecgtdalrfalvsytaqsdki 729
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 657 ILD--RVVEvYR----RLRNTLRFLLANTGDFDIARDGVPVEEWLDIDHYAL-ALTRRLQEQVTGDYArFEFHKIVQALQ 729
Cdd:PLN02381 730 NLDilRVVG-YRqwcnKLWNAVRFAMSKLGDDYTPPATLSVETMPFSCKWILsVLNKAISKTVSSLDA-YEFSDAASTVY 807
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 730 NFAAEDLGAFYVDILKDRLYT-TKADSRARRAAQTALWHITQAITRMMAPILTFTAEEIWR----VTGNDAEDSVMLHTW 804
Cdd:PLN02381 808 SWWQYQFCDVFIEAIKPYFAGdNPEFASERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQrlpqPKDHTRKDSIMISEY 887
|
890 900 910
....*....|....*....|....*....|...
gi 81821070 805 HELPELGASDE-------ILARWELIRSARAEV 830
Cdd:PLN02381 888 PSAVEAWTNEKveyemdlVLSTVKCLRSLRAEV 920
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
50-190 |
1.02e-41 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 155.27 E-value: 1.02e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 50 KFVLHDGPPYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDCHGLPIEHQIEK---QHGKHLPADRARELCREY 126
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERkggRKKKTIWIEEFREDPKEF 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81821070 127 AAEQIERQKKDFIRLGVLGDWDNPYRTMNFSNEADEIRALGELFRKGFLFKGLKPV----NWCFDCGS 190
Cdd:cd00668 81 VEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPVriteQWFFDMPK 148
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
25-788 |
3.09e-37 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 151.06 E-value: 3.09e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 25 EPGWVADWQAKKLYQKvrKAAAGRPKFVLHDGPPYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDCHGLPIEh 104
Cdd:TIGR00396 7 EEKWQQKWDENKTFKV--TDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGLPAE- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 105 QIEKQHGKHlPADRARElcreyaaeQIERQKKDFIRLGVLGDWDNPYRTMNFSNEADEIRALGELFRKGFLFKGLKPVNW 184
Cdd:TIGR00396 84 NAAIKRGIH-PAKWTYE--------NIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNW 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 185 CFDCGSALAEAEVEYQDKKSPAidvGFPLvdnERDKLAHAF------------GLDTLPEQP----------------VY 236
Cdd:TIGR00396 155 CPNDGTVLANEQVDSDGRSWRG---DTPV---EKKELKQWFlkitayaeellnDLEELDHWPesvkemqrnwigksegVE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 237 IV-----------IWTTTPWTIPSNQALNVHPE--LIYELVET-PKGLLILAAELRASALERYQLEgrvlAAARGVALDR 302
Cdd:TIGR00396 229 ITfkiadhdekitVFTTRPDTIFGVTYLALAPEhpLVEKAAENnPKVAAFIKKILNKTVAERTKAT----KEKKGVDTGI 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 303 INFrHPFYDRLSPVFLGDYVAADAGTGIVHSAPAYGLDDFVSCTRYGMRndeILNPVQADGTfagslpffgglsvwdaNP 382
Cdd:TIGR00396 305 KAI-HPLTGEKIPIWVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLP---IKPVIDPAEK----------------DL 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 383 KIVDKLAEVGSLFASGtlTHSYMHcwrhkTPVIYRATTQWFVGMDRlpGREAVEpgsatlrelalkavdetqfYpawgka 462
Cdd:TIGR00396 365 SLTAAYTEDGVLVNSG--EFNGLN-----SSEARNAIIDMLEKEGK--GKRKVN-------------------Y------ 410
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 463 RLHsmianrpDWCVSRQRNWGVPIPLfLHKETGE--PHPRS---LELLEQVAQRVEQHG----IDAWFKLDAaellGSDV 533
Cdd:TIGR00396 411 RLR-------DWGFSRQRYWGEPIPI-IHCEDGGvvPVPEEdlpVILPEDVVYDGDGGSplsrIPEWVNVTC----PSCG 478
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 534 AQYDKMRDTLDVWFDSGtthWTVLR------GSHAAD----SQW-PAALYLEGSDQ------HRGWFHSSLLTGCAIDGR 596
Cdd:TIGR00396 479 KPALRETDTMDTFAGSS---WYYLRyldpknTDGPFDkekaEYWlPVDLYIGGIEHailhllYARFFHKFLRDIGYVNTK 555
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 597 APYDALLTHGFV-------------------------------VDGQGKKMSKSKGNVVAPQEVSDKLGAEILRLWVAat 645
Cdd:TIGR00396 556 EPFKKLINQGMVlgfyyppngkvpadvlterdekgkdkaggelVYVGYEKMSKSKGNGIDPQEIVESYGADALRLFIM-- 633
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 646 dYSGELTISKEILDRVVEVYRR-LRNTLRFLLANTGDFD-IARDGVPVEEwldidhyalaltrrlqEQVTGdyaRFEFHK 723
Cdd:TIGR00396 634 -FMGPIAASLEWNESGLEGARRfLDRVWNLVYEITGELDaASLTVTALEE----------------AQKEL---RRDVHK 693
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81821070 724 IVQAlqnfAAEDLGAFY--------VDILKDRLYTTKADSRARRAAQTALwhitqaitRMMAPILTFTAEEIW 788
Cdd:TIGR00396 694 FLKK----VTEDLEKREsfntaisaMMELLNKLYKAKKEALMLEYLKGFV--------TVLSPFAPHLAEELW 754
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
417-646 |
1.71e-36 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 140.25 E-value: 1.71e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 417 RATTQWFVGMDRLpgreavepgsatlRELALKAVDETQFYPAWGKARLHSMIANRPDWCVSRQRNWGVPIPlflhketge 496
Cdd:cd00668 137 RITEQWFFDMPKF-------------KEKLLKALRRGKIVPEHVKNRMEAWLESLLDWAISRQRYWGTPLP--------- 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 497 phprslelleqvaqrveqhgidawfkldaaellgsdvaqydkmRDTLDVWFDSGTTHWTVLR---GSHAADSQWPAALYL 573
Cdd:cd00668 195 -------------------------------------------EDVFDVWFDSGIGPLGSLGypeEKEWFKDSYPADWHL 231
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81821070 574 EGSDQHRGWFHSSLLTGCAIDGRAPYDALLTHGFVVDGQGKKMSKSKGNVVAPQEVSDKLGAEILRLWVAATD 646
Cdd:cd00668 232 IGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKYGADALRYYLTSLA 304
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
698-853 |
2.66e-32 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 122.51 E-value: 2.66e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 698 DHYALALTRRLQEQVTGDYARFEFHKIVQALQNFAAEDLGAFYVDILKDRLYTTKADSRarraAQTALWHITQAITRMMA 777
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDSR----AQTTLYEVLETLLRLLA 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81821070 778 PILTFTAEEIWRvtgndaEDSVMLHTWHELPELGaSDEILARWELIRsaraEVQKVLESLRSDGRIGASLQAEVRV 853
Cdd:pfam08264 77 PFMPFITEELWQ------KESIHLAPWPEDAELE-EAELEEAFELRQ----EIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
25-804 |
1.47e-28 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 123.24 E-value: 1.47e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 25 EPGWVADWQAKKLYqKVrKAAAGRPKF-VLhDGPPYANGDIHIGHAVNKILKDIIVRSKTLAGFDapyV--P-GWDCHGL 100
Cdd:COG0495 11 EKKWQKYWEENGTF-KA-DEDSSKPKYyVL-DMFPYPSGRLHMGHVRNYTIGDVVARYKRMQGYN---VlhPmGWDAFGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 101 PIE-HQIekQHGKHlPAdrarelcrEYAAEQIERQKKDFIRLGVLGDWDnpyRTMN-------------FSneadeiral 166
Cdd:COG0495 85 PAEnAAI--KNGVH-PA--------EWTYENIANMRRQLKRLGLSYDWS---REIAtcdpeyykwtqwiFL--------- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 167 gELFRKGFLFKGLKPVNWCFDCGSALA------------EAEVE-------------YQDK------------------- 202
Cdd:COG0495 142 -QLYEKGLAYRKEAPVNWCPVDQTVLAneqvidgrcwrcGAPVEkkelpqwflkitdYADEllddldkldgwpekvktmq 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 203 -----KSPAIDVGFPlVDNERDKLahafgldtlpeqPVYiviwTTTPWTI---------PSnqalnvHPeLIYELVETPK 268
Cdd:COG0495 221 rnwigRSEGAEVDFP-VEGSDEKI------------TVF----TTRPDTLfgatfmvlaPE------HP-LVKELATPEQ 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 269 gllilAAELRA--------SALERyQLEGRvlaAARGVALDRinF-RHPFYDRLSPVFLGDYVAADAGTGIVHSAPAYGL 339
Cdd:COG0495 277 -----NAAVAAfieeakkkSEIER-TSETK---EKTGVFTGL--YaINPLTGEKIPIWIADYVLMDYGTGAVMAVPAHDQ 345
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 340 DDFVSCTRYG------MRNDEILNPVQADGTFAG------SlPFFGGLSVWDANPKIVDKLAEVGslfasgtlthsymhc 407
Cdd:COG0495 346 RDFEFAKKYGlpikqvIAPEDGDDPDILEEAYTGdgvlinS-GEFDGLDSEEAKEAIIEWLEEKG--------------- 409
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 408 wrhktpvIYRATTQWfvgmdrlpgreavepgsatlrelalkavdetqfypawgkaRLHsmianrpDWCVSRQRNWGVPIP 487
Cdd:COG0495 410 -------LGKRKVNY----------------------------------------RLR-------DWLISRQRYWGEPIP 435
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 488 LfLHKETGEPHPRS-----LELLEQVAqrveqhgidawFK------LDAAE--------LLGSDvAQydkmR--DTLDVW 546
Cdd:COG0495 436 I-IHCEDCGVVPVPedqlpVELPEDVD-----------FDptggspLARAPewvnvtcpKCGGP-AR----RetDTMDTF 498
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 547 FDSGtthWTVLR------GSHAADSQ----W-PAALYLEGSDqH--------RgwFHSSLL--TGcAIDGRAPYDALLTH 605
Cdd:COG0495 499 VDSS---WYYLRytdphnDEAPFDPEaanyWlPVDQYIGGIE-HailhllyaR--FFTKVLrdLG-LVSFDEPFKRLLTQ 571
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 606 GFVVD--------GQGKKMSKSKGNVVAPQEVSDKLGAEILRLWVAatdYSGELTISKEILDRVVE-VYRRLRNTLRFLL 676
Cdd:COG0495 572 GMVLEvgkdgvviGGIEKMSKSKGNVVDPDEIIEKYGADTLRLFEM---FAGPPERDLEWSDSGVEgAYRFLNRVWRLVV 648
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 677 ANTGDFDIARDgvpveewlDIDHYALALTRRLQE---QVTGDYARFEFHKIVQALQNFAAEdlgafyvdilkdrLYTTKA 753
Cdd:COG0495 649 DEAEALKLDVA--------DLSEADKELRRALHKtikKVTEDIERLRFNTAIAALMELVNA-------------LYKAKD 707
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|..
gi 81821070 754 DSRARRAA-QTALwhitQAITRMMAPILTFTAEEIWRVTGNdaEDSVMLHTW 804
Cdd:COG0495 708 SGEADRAVlREAL----ETLVLLLAPFAPHIAEELWERLGH--EGSVADAPW 753
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
64-825 |
4.79e-25 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 112.27 E-value: 4.79e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 64 IHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDCHGLPI-----------EHQIE---KQHGKhlPADrarELCR----- 124
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPIlgiaeriargdPETIElykSLYGI--PEE---ELEKfkdpe 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 125 ---EYAAEQIerqKKDFIRLGVLGDWDNPYRTmnfsneADEI---------RALGElfrKGFLFKGLKPVNWCFDCGSAL 192
Cdd:PRK12300 76 yivEYFSEEA---KEDMKRIGYSIDWRREFTT------TDPEyskfiewqfRKLKE---KGLIVKGSHPVRYCPNDNNPV 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 193 AEAEVeyQDKKSPAIdVGFPLVDNERDKLAhafgldtlpeqpvYIVIWTTTPWTIPSNQALNVHPELIYELVETPKGLLI 272
Cdd:PRK12300 144 GDHDL--LDGEEPEI-VEYTLIKFEESEDL-------------ILPAATLRPETIFGVTNLWVNPDATYVKAEVDGEKWI 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 273 LAAElrasALER--YQL-EGRVLAAARGVALDRINFRHPFYDRLSPVFLGDYVAADAGTGIVHSAPAYGLDDFVSCTRYG 349
Cdd:PRK12300 208 VSKE----AAEKlsFQDrDVEIIEEIKGSELIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDYVALRDLK 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 350 mRNDEILNPV---------------------------QAD-----------------GTFAGSLPFFGGLSVWDANPKIV 385
Cdd:PRK12300 284 -KNKELLDVIepiplievegygefpakevveklgiksQEDpeleeatkevyraefhkGVLKENTGEYAGKPVREAREKIT 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 386 DKLAEVGSL-----FASGtlthsymhcwrhktPVIYRATT---------QWFVgmdrlpgreavEPGSATLRELALKAVD 451
Cdd:PRK12300 363 KDLIEKGIAdimyeFSNR--------------PVYCRCGTecvvkvvkdQWFI-----------DYSDPEWKELAHKALD 417
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 452 ETQFYPAWGKARLHSMIANRPDWCVSRQRNWGVPIPlFLHKETGEPhprslelLEQ---------VAQRVEQHGIDaWFK 522
Cdd:PRK12300 418 NMEIIPEEYRKEFENTIDWLKDRACARRRGLGTRLP-WDEEWIIES-------LSDstiymayytIAHKIREYGIK-PEQ 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 523 L----------------DAAELLGSDVAQYDKMRDTLDVWF--DSGTT-------HWTVLRGSHAA---DSQWPAALyle 574
Cdd:PRK12300 489 LtpeffdyvflgkgdpeEVSKKTGIPKEILEEMREEFLYWYpvDWRHSgkdlipnHLTFFIFNHVAifpEEKWPRGI--- 565
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 575 gsdqhrgwfhsslltgcAIDGrapydallthgFVVDGqGKKMSKSKGNVVAPQEVSDKLGAEILRLWVAAT-DYSGELTI 653
Cdd:PRK12300 566 -----------------VVNG-----------FVLLE-GKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSaELLQDADW 616
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 654 SKEILDRVVEVYRRLRNTLRFLLANTGDfdiardgvpvEEWLDIDHYALALTRRLQEQVTGDYARFEFHkivQALQNfaa 733
Cdd:PRK12300 617 REKEVESVRRQLERFYELAKELIEIGGE----------EELRFIDKWLLSRLNRIIKETTEAMESFQTR---DAVQE--- 680
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 734 edlgAFYvDILKD-RLYTtkadSRARRAAQTALWHITQAITRMMAPILTFTAEEIWRVTGNdaEDSVMLHTWHELPELGA 812
Cdd:PRK12300 681 ----AFY-ELLNDlRWYL----RRVGEANNKVLREVLEIWIRLLAPFTPHLAEELWHKLGG--EGFVSLEKWPEPDESKI 749
|
890
....*....|...
gi 81821070 813 SDEILARWELIRS 825
Cdd:PRK12300 750 DEEAELAEEYVKR 762
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
22-806 |
1.10e-23 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 107.99 E-value: 1.10e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 22 AKREPGWVADWQAKKLYQKVRKAAAGRPKFVLHDGPPYANG-DIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDCHGL 100
Cdd:PLN02563 83 HEIEPKWQRYWEENRTFRTPDDVDTSKPKFYVLDMFPYPSGaGLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 101 PIEhQIEKQHGKHlPadrarelcREYAAEQIERQKKDFIRLGVLGDWDNPYRTMnfsnEADEIR-----ALgELFRKGFL 175
Cdd:PLN02563 163 PAE-QYAIETGTH-P--------KITTLKNIARFRSQLKSLGFSYDWDREISTT----EPEYYKwtqwiFL-QLLKRGLA 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 176 FKGLKPVNWCFDCGSALAEAEV-------------------------EYQDK-----------------------KSPAI 207
Cdd:PLN02563 228 YQAEVPVNWCPALGTVLANEEVvdglsergghpvirkpmrqwmlkitAYADRlledlddldwpesikemqrnwigRSEGA 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 208 DVGFPLVDnerdklahafglDTLPEQPVYIVIWTTTPWTIPSNQALNVHPEliYELVETpkglliLAAELRASALERYql 287
Cdd:PLN02563 308 ELDFSVLD------------GEGKERDEKITVYTTRPDTLFGATYLVVAPE--HPLLSS------LTTAEQKEAVEEY-- 365
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 288 egrVLAAARGVALDRINF-------------RHPFYDRLSPVFLGDYVAADAGTGIVHSAPAYGLDDFVSCTRYGM---- 350
Cdd:PLN02563 366 ---VDAASRKSDLERTELqkektgvftgsyaINPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLpikw 442
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 351 ---RNDEILNPVQADGTFAGSL-------PFFGGLSVWDANPKIVDKLAEVGSlfasgtlthsymhcwrHKTPVIYRatt 420
Cdd:PLN02563 443 vvkPADGNEDDAEKAYTGEGVIvnssssgLDINGLSSKEAAKKVIEWLEETGN----------------GKKKVNYK--- 503
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 421 qwfvgmdrlpgreavepgsatLRelalkavdetqfypawgkarlhsmianrpDWCVSRQRNWGVPIPLFLHKETGEPHPR 500
Cdd:PLN02563 504 ---------------------LR-----------------------------DWLFARQRYWGEPIPVVFLEDSGEPVPV 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 501 S-----LELLEqvaqrveqhgIDAWFKLDAAELLGSDVAQYDKMRDTLD-VWFDSGTTH--------WTVLRG------- 559
Cdd:PLN02563 534 PesdlpLTLPE----------LDDFTPTGTGEPPLAKAVSWVNTVDPSSgKPARRETNTmpqwagscWYYLRFmdpknsn 603
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 560 ---SHAADSQW-PAALYLEGSDQ---H----RGWfHSSLLTGCAIDGRAPYDALLTHGFV---------VDGQGK----- 614
Cdd:PLN02563 604 alvDKEKEKYWmPVDLYVGGAEHavlHllyaRFW-HKVLYDIGVVSTKEPFQCLVNQGMIlgeveytafKDSDGEyvsad 682
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 615 ----------------------------------------KMSKSKGNVVAPQEVSDKLGAEILRLWVAatdYSGELTIS 654
Cdd:PLN02563 683 tadrlgelqqekipeekviksgdsfvlkddpsirliarahKMSKSRGNVVNPDDVVSEYGADSLRLYEM---FMGPLRDS 759
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 655 KEILDRVVE-VYRRLRNTLRFLL---ANTG---DFDIARDGVPVEEWLDIDHYALAltrrlqeQVTGDYARFEFHKIVQA 727
Cdd:PLN02563 760 KTWSTSGVEgVHRFLGRTWRLVVgapLPDGsfrDGTVVTDEEPSLEQLRLLHKCIA-------KVTEEIESTRFNTAISA 832
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 728 LQNF--AAedlgafyvdilkdrlytTKADSRARRAAqtalwhitQAITRMMAPILTFTAEEIWRVTGNdaEDSVMLHTWH 805
Cdd:PLN02563 833 MMEFtnAA-----------------YKWDKVPREAI--------EPFVLLLSPYAPHLAEELWFRLGH--SNSLAYEPWP 885
|
.
gi 81821070 806 E 806
Cdd:PLN02563 886 E 886
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
58-807 |
1.64e-17 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 87.09 E-value: 1.64e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 58 PYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDCHGLPIEHQIEKQhGKHlPadrarelcREYAAEQIERQKKD 137
Cdd:COG0143 10 PYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKE-GIT-P--------QELVDRIHAEFKEL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 138 FIRLGVlgDWDNPYRTmnfsNEADEIRALGELFRKgflfkglkpvnwcfdcgsalaeaeveyqdkkspaidvgfpLVDNe 217
Cdd:COG0143 80 FEKLGI--SFDNFIRT----TSPEHKELVQEIFQR----------------------------------------LYDN- 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 218 rdklahafGldtlpeqpvyiviwtttpwtipsnqalnvhpeLIYElvetpkgllilaaelrasalERYqlEGrvlaaarg 297
Cdd:COG0143 113 --------G--------------------------------DIYK--------------------GEY--EG-------- 122
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 298 valdrinfrhpFYDrlsPV---FLGD-YVaadAGTG-IVHSAPAYGlDDFVSCTRYGMRNDEIlNPVQADgtfagslpff 372
Cdd:COG0143 123 -----------WYC---PEcerFLPDrYV---EGTCpKCGAEDAYG-DQCENCGATLEPTELI-NPRSAI---------- 173
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 373 gglsvwdanpkivdklaevgslfasgtlthsymhcwrHKTPVIYRATTQWFVGMDRLpgreavepgSATLRELalkavde 452
Cdd:COG0143 174 -------------------------------------SGAPPELREEEHYFFRLSKY---------QDRLLEW------- 200
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 453 TQFYPAWGKAR---LHSMIANR-PDWCVSRQRNWGVPIPlflhketGEPhprslelleqvaqrveqhgidawfkldaael 528
Cdd:COG0143 201 IEENPDIQPEVrneVLSWLKEGlQDLSISRDFDWGIPVP-------GDP------------------------------- 242
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 529 lgsdvaqyDKmrdTLDVWFD------SGTTHWTVLRGSHAA-DSQWPAA----LYLEGSDQHRgwFHS----SLLTGCai 593
Cdd:COG0143 243 --------GK---VFYVWFDaligyiSATKGYADDRGLPEDfEKYWPAPdtelVHFIGKDIIR--FHAiiwpAMLMAA-- 307
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 594 dGRAPYDALLTHGFV-VDGQgkKMSKSKGNVVAPQEVSDKLGAEILRLWVAA-------TDYSGEltiskEILDRVvevy 665
Cdd:COG0143 308 -GLPLPKKVFAHGFLtVEGE--KMSKSRGNVIDPDDLLDRYGPDALRYYLLRevpfgqdGDFSWE-----DFVARV---- 375
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 666 rrlrNTlrfLLANT-GDFdIAR---------DGV--PVEEWLDIDHYALALTRRLQEQVTGDYARFEFHKIVQALQNFAa 733
Cdd:COG0143 376 ----NS---DLANDlGNL-ASRtlsmihkyfDGKvpEPGELTEADEELLAEAEAALEEVAEAMEAFEFRKALEEIMALA- 446
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 734 eDLGAFYVDilkdrlyTTK----ADSRARRAAQTALWHITQAI---TRMMAPILTFTAEEIWRVTGNDAEDsvmlHTWHE 806
Cdd:COG0143 447 -RAANKYID-------ETApwklAKDEDPERLATVLYTLLEALrilAILLKPFLPETAEKILEQLGLEGDE----LTWED 514
|
.
gi 81821070 807 L 807
Cdd:COG0143 515 A 515
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
661-789 |
3.17e-17 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 79.14 E-value: 3.17e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 661 VVEVYRRLRNTL----RFLLANTGDFDIARDGVPVEEWldIDHYALALTRRLQEQVTGDYARFEFHKIVQALQNFAAEDL 736
Cdd:cd07962 5 RVEGGRNFCNKLwnaaRFVLMNLEDDDEPEEDPESLSL--ADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFWNDF 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 81821070 737 GAFYVDILKDRLYttKADSRARRAAQTALWHITQAITRMMAPILTFTAEEIWR 789
Cdd:cd07962 83 CDWYLELVKPRLY--GEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQ 133
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
661-838 |
5.36e-15 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 74.12 E-value: 5.36e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 661 VVEVYRR----LRNTLRFLL--ANTGDFDIARDGVPVEEWLDIDHYALALTRRLQEQVTGDYARFEFHKIVQALQNFAAE 734
Cdd:cd07961 6 VREVVRKvllpLWNAYRFFVtyANLDGFDPGKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFIDE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 735 DLGaFYVDILKDRLYTTKADSrARRAAQTALWHITQAITRMMAPILTFTAEEIW---RVTGNDAEDSVMLHTWhelPELg 811
Cdd:cd07961 86 LTN-WYIRRNRKRFWGEEGDD-DKLAAYATLYEVLLTLSRLMAPFTPFITEEIYqnlRRELGDAPESVHLLDW---PEV- 159
|
170 180
....*....|....*....|....*..
gi 81821070 812 asDEILARWELIRSArAEVQKVLESLR 838
Cdd:cd07961 160 --DESLIDEELEEAM-ELVREIVELGR 183
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
58-194 |
2.06e-14 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 75.26 E-value: 2.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 58 PYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDCHGLPIEhQIEKQHGKHlPadraRELCREYAaeqiERQKKD 137
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIE-QKAEEEGVT-P----QELCDKYH----EIFKDL 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81821070 138 FIRLGVlgDWDNPYRTmnfsNEADEIRALGELFRK----GFLFKGLKPVNWCFDCGSALAE 194
Cdd:cd00814 79 FKWLNI--SFDYFIRT----TSPRHKEIVQEFFKKlyenGYIYEGEYEGLYCVSCERFLPE 133
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
58-198 |
1.30e-13 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 74.72 E-value: 1.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 58 PYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDCHGLPIEHQIEKQhGKHlPadraRELCREYAAEqierQKKD 137
Cdd:TIGR00398 8 PYANGKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKIELKAEQE-GLT-P----KELVDKYHEE----FKDD 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81821070 138 FIRLGVlgDWDNPYRTMNFSNEADEIRALGELFRKGFLFKGLKPVNWCFDCGSALAEAEVE 198
Cdd:TIGR00398 78 WKWLNI--SFDRFIRTTDEEHKEIVQKIFQKLKENGYIYEKEIKQLYCPECEMFLPDRYVE 136
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
58-198 |
2.61e-13 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 72.71 E-value: 2.61e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 58 PYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDCHGLPIEHQIEKqHGKhlpadRARELCREYAaeqiERQKKD 137
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEK-EGI-----TPEELVDRYH----EIHRED 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 81821070 138 FIRLGVlgDWDNPYRTmnfsNEADEIRALGELFR----KGFLFKGLKPVNWCFDCGSALAEAEVE 198
Cdd:pfam09334 78 FKKFNI--SFDDYGRT----TSERHHELVQEFFLklyeNGYIYEKEIEQFYCPSDERFLPDRYVE 136
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
542-823 |
5.19e-12 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 69.53 E-value: 5.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 542 TLDVWFDSGTTHWTVLRGSHAADSQ-------WPAALYLEGSDQHRgwFHS----SLLTgcAIDGRAPyDALLTHGF-VV 609
Cdd:PRK11893 221 VIYVWFDALTNYLTALGYPDDEELLaelfnkyWPADVHLIGKDILR--FHAvywpAFLM--AAGLPLP-KRVFAHGFlTL 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 610 DGQgkKMSKSKGNVVAPQEVSDKLGAEILRLWVAAT-------DYSgeltiskeiLDRVVEVYRR-LRNTLRFLLANTGD 681
Cdd:PRK11893 296 DGE--KMSKSLGNVIDPFDLVDEYGVDAVRYFLLREipfgqdgDFS---------REAFINRINAdLANDLGNLAQRTLS 364
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 682 FdIAR--DG-VPVEEWLDI-DHYALALTRRLQEQVTGDYARFEFHKIVQALQNFAAEDLGafYVDILKdrLYTTKADSRA 757
Cdd:PRK11893 365 M-IAKnfDGkVPEPGALTEaDEALLEAAAALLERVRAAMDNLAFDKALEAILALVRAANK--YIDEQA--PWSLAKTDPE 439
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81821070 758 RRAaqTALWHI---TQAITRMMAPILTFTAEEIWRVTGNDAEDSVMLHT--WHELPE---LGASDEILARWELI 823
Cdd:PRK11893 440 RLA--TVLYTLlevLRGIAVLLQPVMPELAAKILDQLGVEEDENRDFAAlsWGRLAPgttLPKPEPIFPRLEEE 511
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
58-185 |
1.12e-11 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 66.89 E-value: 1.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 58 PYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDCHGLPIEhQIEKQHGKHlPADRARelcreyaaEQIERQKKD 137
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAE-NAAIKIGRD-PEDWTE--------YNIKKMKEQ 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 81821070 138 FIRLGVLGDWDNPYRTMN--FSneaDEIRAL-GELFRKGFLFKGLKPVNWC 185
Cdd:cd00812 79 LKRMGFSYDWRREFTTCDpeYY---KFTQWLfLKLYEKGLAYKKEAPVNWC 126
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
472-644 |
1.74e-11 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 66.40 E-value: 1.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 472 PDWCVSRQR-NWGVPIPLFlhketgephprslelleqvaqrvEQHGIDAWFklDAaeLLG--SDVAQYDKMRDTLDVWFD 548
Cdd:cd00814 180 KDLSITRDLfDWGIPVPLD-----------------------PGKVIYVWF--DA--LIGyiSATGYYNEEWGNSWWWKD 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 549 sgtthwtvlrgshaadsQWPAALYLEGSDQHRgwFHS----SLLTGCaidGRAPYDALLTHGFVVDGqGKKMSKSKGNVV 624
Cdd:cd00814 233 -----------------GWPELVHFIGKDIIR--FHAiywpAMLLGA---GLPLPTRIVAHGYLTVE-GKKMSKSRGNVV 289
|
170 180
....*....|....*....|
gi 81821070 625 APQEVSDKLGAEILRLWVAA 644
Cdd:cd00814 290 DPDDLLERYGADALRYYLLR 309
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
58-153 |
4.42e-11 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 66.71 E-value: 4.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 58 PYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDCHGLPIEHQIEKQhGKHlPadraRELCREYAAEqierQKKD 137
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKE-GIT-P----EELIARYHAE----HKRD 80
|
90
....*....|....*.
gi 81821070 138 FIRLGVlgDWDNPYRT 153
Cdd:PRK00133 81 FAGFGI--SFDNYGST 94
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
605-683 |
1.78e-09 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 61.27 E-value: 1.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 605 HGFV-VDGQgkKMSKSKGNVVAPQEVSDKLGAEILRLWVAATDYSGELTISKEILDRVVEVYRRLRNTLRFLLANTGDFD 683
Cdd:COG0215 256 NGFLtVNGE--KMSKSLGNFFTVRDLLKKYDPEVLRFFLLSAHYRSPLDFSEEALEEAEKALERLYNALRRLEEALGAAD 333
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
656-780 |
1.80e-09 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 56.36 E-value: 1.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 656 EILDRVVEVYRRLRNTLRFLLANTGDFDIARDGvpvEEWLDIDHYALALTRRLQEQVTGDYARFEFHKIVQALQNFAAED 735
Cdd:cd07375 2 ERLKQARAFLNRLYRLLSFFRKALGGTQPKWDN---ELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNEL 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 81821070 736 lgAFYVDILKDRLYTTKADSRARRAAQTALWHITQaitrMMAPIL 780
Cdd:cd07375 79 --NWYLDELKPALQTEELREAVLAVLRAALVVLTK----LLAPFT 117
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
413-643 |
2.39e-09 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 59.95 E-value: 2.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 413 PVIYRA-TTQWFVGMdrlpgreavepGSATLRELALKAVDETQFYPAWGKARLHSMIAnrpdwcVSRQRNWGVPIPlflh 491
Cdd:cd00812 122 PVNWCKlLDQWFLKY-----------SETEWKEKLLKDLEKLDGWPEEVRAMQENWIG------CSRQRYWGTPIP---- 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 492 ketgephprslelleqvaqrveqhgidawfkldaaellgsdvaqydkMRDTLDVWFDSG-------TTHWT------VLR 558
Cdd:cd00812 181 -----------------------------------------------WTDTMESLSDSTwyyarytDAHNLeqpyegDLE 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 559 GSHAADSQW-PAALYLEGSDQ-------HRgwFHSSLLTGCAIDGRAPYDALLTHGFVVdGQGKKMSKSKGNVVAPQEVS 630
Cdd:cd00812 214 FDREEFEYWyPVDIYIGGKEHapnhllySR--FNHKALFDEGLVTDEPPKGLIVQGMVL-LEGEKMSKSKGNVVTPDEAI 290
|
250
....*....|...
gi 81821070 631 DKLGAEILRLWVA 643
Cdd:cd00812 291 KKYGADAARLYIL 303
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
545-639 |
5.84e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 56.73 E-value: 5.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 545 VWFDSGTTHWTVLRGSHAADSQ----WPAALYLEGSDQHRgwFHS--------SLltgcaidGRAPYDALLTHG-FVVDG 611
Cdd:PRK12267 227 VWIDALLNYITALGYGSDDDELfkkfWPADVHLVGKDILR--FHAiywpimlmAL-------GLPLPKKVFAHGwWLMKD 297
|
90 100
....*....|....*....|....*...
gi 81821070 612 QgkKMSKSKGNVVAPQEVSDKLGAEILR 639
Cdd:PRK12267 298 G--KMSKSKGNVVDPEELVDRYGLDALR 323
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
567-816 |
1.72e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 55.16 E-value: 1.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 567 WPAalYLEGSdqhrGWfhsslltgcaidgRAPyDALLTHGFV-VDGqgKKMSKSKGNVVAPQEVSDKLGAEILRLWVAA- 644
Cdd:PRK00133 302 WPA--MLEGA----GY-------------RLP-TNVFAHGFLtVEG--AKMSKSRGTFIWARTYLDHLDPDYLRYYLAAk 359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 645 -------TDYSGELTISK---EILDRVVE-VYRrlrnTLRFLLANtgdFDiarDGVPVEEwldIDHYALALTRRLQEQVT 713
Cdd:PRK00133 360 lpetiddLDFNWEDFQQRvnsELVGKVVNfASR----TAGFINKR---FD---GKLPDAL---ADPELLEEFEAAAEKIA 426
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 714 GDYARFEFHKIVQALQNFAaeDLGAFYVDilkdrlyTTK----ADSRARRAAQT---ALwHITQAITRMMAPILTFTAEE 786
Cdd:PRK00133 427 EAYEAREFRKALREIMALA--DFANKYVD-------DNEpwklAKQDGERLQAVcsvGL-NLFRALAIYLKPVLPELAER 496
|
250 260 270
....*....|....*....|....*....|
gi 81821070 787 IWRVTGNDAedsvmlHTWHELPELGASDEI 816
Cdd:PRK00133 497 AEAFLNLEE------LTWDDAQQPLAGHPI 520
|
|
| zf-FPG_IleRS |
pfam06827 |
Zinc finger found in FPG and IleRS; This zinc binding domain is found at the C-terminus of ... |
900-925 |
2.66e-07 |
|
Zinc finger found in FPG and IleRS; This zinc binding domain is found at the C-terminus of isoleucyl tRNA synthetase and the enzyme Formamidopyrimidine-DNA glycosylase EC:3.2.2.23.
Pssm-ID: 429140 [Multi-domain] Cd Length: 28 Bit Score: 47.20 E-value: 2.66e-07
10 20
....*....|....*....|....*.
gi 81821070 900 QKCGRCWHFREDIGVDADHPELCGRC 925
Cdd:pfam06827 2 EKCPRCWTYIEKVGVGGRSTYFCPRC 27
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
59-112 |
1.66e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 51.72 E-value: 1.66e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 81821070 59 YANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDCHGLPIEhQIEKQHGK 112
Cdd:PRK12267 14 YPNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHGQKIQ-QAAEKAGK 66
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
57-140 |
2.28e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 51.42 E-value: 2.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 57 PPYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDCHGLPIEhQIEKQHGKHlpadrARELCREYAAEQIERQKK 136
Cdd:PRK11893 9 IYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQ-RKAEEAGIS-----PQELADRNSAAFKRLWEA 82
|
90
....*....|
gi 81821070 137 ------DFIR 140
Cdd:PRK11893 83 lnisydDFIR 92
|
|
| tRNA-synt_1f |
pfam01921 |
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from ... |
585-670 |
5.83e-06 |
|
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from prokaryotes.
Pssm-ID: 396483 Cd Length: 357 Bit Score: 49.57 E-value: 5.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 585 SSLLTGCAIDGRAPYdaLLTHGFVVDGQGKKMSKSKGNVVAPQEVSDKLGAEILRLWVAATDYSGELTISKEILDRVVEV 664
Cdd:pfam01921 251 SSRIADEIFGGEPPE--GFPYELILLKGGGKMSSSKGNVITPEDWLEYAPPESLRFLMFRTKPKKAKDLDFDVIPRLVDE 328
|
....*.
gi 81821070 665 YRRLRN 670
Cdd:pfam01921 329 YDRLER 334
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
537-806 |
7.16e-06 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 49.71 E-value: 7.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 537 DKMRDTLDVWFDSGTTHWTVLRGSH-------AADSQWPAALYLEGSDQHRgwFHSSLLTGCAID-GRAPYDALLTHGFV 608
Cdd:PLN02224 283 DDDKQTIYVWFDALLGYISALTEDNkqqnletAVSFGWPASLHLIGKDILR--FHAVYWPAMLMSaGLELPKMVFGHGFL 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 609 VDgQGKKMSKSKGNVVAPQEVSDKLGAEILR-LWVAATDYSGELTISKEILDRVVEVYrrLRNTLRFLLANT-------- 679
Cdd:PLN02224 361 TK-DGMKMGKSLGNTLEPFELVQKFGPDAVRyFFLREVEFGNDGDYSEDRFIKIVNAH--LANTIGNLLNRTlgllkknc 437
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 680 -----GDFDIARDGVPVEEWLDidhyalaltrRLQEQVTGDYARFEFHKIVQALQNFAaeDLGAFYVDILKDRLYTTKAD 754
Cdd:PLN02224 438 estlvEDSTVAAEGVPLKDTVE----------KLVEKAQTNYENLSLSSACEAVLEIG--NAGNTYMDQRAPWFLFKQGG 505
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 81821070 755 SRARRAAQ--TALWHITQAITRMMAPILTFTAEEIWRVTGNdAEDSVMLHTWHE 806
Cdd:PLN02224 506 VSAEEAAKdlVIILEVMRVIAVALSPIAPCLSLRIYSQLGY-SEDQFNSITWSD 558
|
|
| lysK |
PRK00750 |
lysyl-tRNA synthetase; Reviewed |
594-669 |
2.90e-05 |
|
lysyl-tRNA synthetase; Reviewed
Pssm-ID: 234829 [Multi-domain] Cd Length: 510 Bit Score: 47.88 E-value: 2.90e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81821070 594 DGRAPYdaLLTHGFVVDGQGKKMSKSKGNVVAPQEVSDKLGAEILRLWVAAtDYSGELTISKEILDRVVEVYRRLR 669
Cdd:PRK00750 261 GGEPPE--PFVYELFLDKKGEKISKSKGNVITIEDWLEYAPPESLRLFMFA-RPKPAKRLDFDVIPKLVDEYDRFE 333
|
|
| LysS |
COG1384 |
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA ... |
594-640 |
1.75e-04 |
|
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA synthetase, class I is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440994 [Multi-domain] Cd Length: 525 Bit Score: 45.19 E-value: 1.75e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 81821070 594 DGRAPYdaLLTHGFVVDGQGKKMSKSKGNVVAPQEVSDKLGAEILRL 640
Cdd:COG1384 268 GGEPPE--GFVYELFLDENGEKISKSKGNGLTVEEWLEYAEPESLRY 312
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
605-647 |
2.13e-03 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 40.64 E-value: 2.13e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 81821070 605 HGFV-VDGQgkKMSKSKGNVVAPQEVSDKLGAEILRLWVAATDY 647
Cdd:cd00672 165 TGHLtIDGE--KMSKSLGNFITVRDALKKYDPEVLRLALLSSHY 206
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
683-789 |
3.93e-03 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 37.96 E-value: 3.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81821070 683 DIARDGVPVEEWLDIDHYALALTRRLQEQVTGDYARFEFHKIVQAlqnfaaedlgAFYvDILKD-RLYTTKADSRARRAA 761
Cdd:cd07959 22 ELIETEGELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALKE----------GLY-ELQNDlDWYRERGGAGMNKDL 90
|
90 100
....*....|....*....|....*...
gi 81821070 762 qtaLWHITQAITRMMAPILTFTAEEIWR 789
Cdd:cd07959 91 ---LRRFIEVWTRLLAPFAPHLAEEIWH 115
|
|
| |
