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Conserved domains on  [gi|341940690|sp|Q61555|]
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RecName: Full=Fibrillin-2; Contains: RecName: Full=Placensin; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fibrillin_U_N pfam18193
Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. ...
 76-112 6.97e-15

Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.


:

Pssm-ID: 436338  Cd Length: 37  Bit Score: 70.70  E-value: 6.97e-15
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 341940690    76 RRGQQEILRGPNVCGSRFHSYCCPGWKTLPGGNQCIV 112
Cdd:pfam18193    1 RRGGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1741-1784 1.53e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 61.14  E-value: 1.53e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 341940690  1741 TCENELPFNVTKRMCCCTYnVGKAWNKPCEPCPTPGTADFKTIC 1784
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTS-VGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 706-749 6.71e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 56.52  E-value: 6.71e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 341940690   706 GVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLC 749
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2104-2148 2.07e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 2.07e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 341940690  2104 GKCSVPKAFNTTKAKCCCSKMpGEGWGDPCELCPKDDEVAFQDLC 2148
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSV-GRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1003-1045 1.07e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 53.05  E-value: 1.07e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 341940690  1003 DECIHPVPGKFRMDACCCA-VGAAWGTECEECPKPGTKEYETLC 1045
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1405-1440 1.77e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 52.22  E-value: 1.77e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 341940690  1405 CANGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTC 1440
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2387-2430 6.00e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 51.12  E-value: 6.00e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 341940690  2387 MCQMASSSRnlVTKSECCCD-GGRGWGHQCELCPLPGTAQYKKIC 2430
Cdd:pfam00683    2 RCSNPLPGN--VTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1586-1626 1.73e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 49.58  E-value: 1.73e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 341940690  1586 CNTEVGVGVSRSSCCC-SLGKAWGNPCETCPPVNSTEYYTLC 1626
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 373-417 3.40e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 3.40e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 341940690   373 GRCAQELPGRMAKAQCCCE-PGRCWsiGTIPEACPVRGSEEYRRLC 417
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAW--GSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1364-1399 5.35e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.28  E-value: 5.35e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 341940690  1364 CEIGAHNCDMHASCLNVPGSFKCSCREGWVGNGIKC 1399
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1239-1274 1.31e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 1.31e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 341940690  1239 CMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC 1274
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
2206-2245 4.30e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 4.30e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 341940690   2206 DTDECSIGNPCGNG-TCTNVIGSFECTCNEGFEPGpmMNCE 2245
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2488-2523 5.53e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.23  E-value: 5.53e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 341940690  2488 CSQSPKPCNFICKNTKGSYQCSCPRGYVLQEDGKTC 2523
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1843-1875 1.29e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 1.29e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 341940690   1843 DIDECSNGdNLCQRNADCINSPGSYRCECAAGF 1875
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
651-691 1.53e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.53e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 341940690    651 DVDECQTPGICMNG-HCINNEGSFRCDCPPGLavgVDGRVCV 691
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1927-1961 1.80e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.80e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 341940690   1927 DVDECE-RHPCGNG-TCKNTVGSYNCLCYPGFELTHN 1961
Cdd:smart00179    1 DIDECAsGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 898-928 2.51e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 40.72  E-value: 2.51e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 341940690   898 NRCEVNINGATLKSECC-ATLGAAWGSPCERC 928
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCcTSVGRAWGSPCELC 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2164-2205 2.62e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.62e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 341940690   2164 DVNEClESPGICSNG-QCINTDGSFRCECPMGYnldYTGVRCV 2205
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
528-558 2.84e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 2.84e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 341940690    528 DVDECTS-NPCSNG-DCVNTPGSYYCKCHAGFQ 558
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
568-609 3.59e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.59e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 341940690    568 DIDECIQNGVLCKNGRCVNTDGSFQCICNAGFeltTDGKNCV 609
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1643-1675 5.75e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 5.75e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 341940690   1643 DIDECQELPGLCQGGNCINTFGSFQCECPQGYY 1675
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 803-838 6.44e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 6.44e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 341940690  803 DIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRT 838
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1151-1183 7.65e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 7.65e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 341940690   1151 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHE 1183
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2049-2089 9.50e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 9.50e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 341940690   2049 DINECdEDPNICLFGS-CTNTPGGFQCICPPGFVlsdNGRRC 2089
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYT---DGRNC 38
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2821-2868 1.12e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 40.76  E-value: 1.12e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 341940690 2821 EPLNNHIRYVISQGNEDGVFRIHQRNGLsyLHTaKKKL---APGTYTLEIT 2868
Cdd:cd11304    26 SGENGEVTYSIVSGNEDGLFSIDPSTGE--ITT-AKPLdreEQSSYTLTVT 73
EGF_CA smart00179
Calcium-binding EGF-like domain;
1108-1142 1.22e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.22e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 341940690   1108 DIDECRiSPDLCGSG-ICVNTPGSFECECFEGYESG 1142
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
1966-2008 1.29e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.29e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 341940690   1966 DIDECSSffGQVCRNG-RCFNEIGSFKCLCNEGYEltpDGKNCI 2008
Cdd:smart00179    1 DIDECAS--GNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
610-650 1.39e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.39e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 341940690    610 DHDECTTTNMCLNG-MCINEDGSFKCVCKPGFIlapNGRYCT 650
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
2607-2636 1.49e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.49e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 341940690   2607 DVDECDGNHRCQHG--CQNILGGYRCGCPQGY 2636
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1525-1556 1.55e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.55e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 341940690   1525 DIDECADPINCVNG-LCVNTPGRYECNCPPDFQ 1556
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
2525-2554 1.61e-03

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.61e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 341940690  2525 DLDECQTKQHNCQ--FLCVNTLGGFTCKCPPG 2554
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1193-1225 1.72e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.72e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 341940690   1193 DINECSlSDNLCRNG-KCVNMIGTYQCSCNPGYQ 1225
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1801-1833 2.01e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.01e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 341940690   1801 DIDECKEiPGICANG-VCINQIGSFRCECPTGFS 1833
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYT 33
vWFA super family cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 1880-1922 2.34e-03

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


The actual alignment was detected with superfamily member cd01475:

Pssm-ID: 469594 [Multi-domain]  Cd Length: 224  Bit Score: 41.99  E-value: 2.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 341940690 1880 NGACVDRNECLEIPNVCSHGlCVDLQGSYQCICNNGFKASQDQ 1922
Cdd:cd01475   181 GKICVVPDLCATLSHVCQQV-CISTPGSYLCACTEGYALLEDN 222
EGF_CA smart00179
Calcium-binding EGF-like domain;
761-802 4.50e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 4.50e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 341940690    761 DINECAlDPDICANG-ICENLRGSYRCNCNSGYEpdaSGRNCI 802
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
948-978 4.94e-03

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 4.94e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 341940690   948 DVNECEVFPGVCP-NGRCVNSKGSFHCECPEG 978
Cdd:pfam07645    1 DVDECATGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
276-306 5.27e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.27e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 341940690    276 DVDECqAIPGLCQ-GGNCINTVGSFECRCPAG 306
Cdd:smart00179    1 DIDEC-ASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1484-1519 5.70e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.70e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 341940690   1484 DIDECSFQNICVFG-TCNNLPGMFHCICDDGYELDRT 1519
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
2442-2475 6.29e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 6.29e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 341940690   2442 DIDECKvMPSLCTNG-QCVNTMGSFRCFCKVGYTT 2475
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD 34
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 224-257 7.21e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.49  E-value: 7.21e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 341940690   224 MCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQ 257
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPP 35
EGF_CA pfam07645
Calcium-binding EGF domain;
2287-2319 7.40e-03

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 7.40e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 341940690  2287 DLDECAEGLHDCeSRGMMCKNLIGTFMCICPPG 2319
Cdd:pfam07645    1 DVDECATGTHNC-PANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2009-2041 7.74e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.74e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 341940690   2009 DTNECvALPGSCSPG-TCQNLEGSFRCICPPGYE 2041
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2564-2606 8.29e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 8.29e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 341940690   2564 DNNECgSQPSLCGAKGICQNTPGSFSCECQRGFSldaSGLNCE 2606
Cdd:smart00179    1 DIDEC-ASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
 
Name Accession Description Interval E-value
Fibrillin_U_N pfam18193
Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. ...
 76-112 6.97e-15

Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.


Pssm-ID: 436338  Cd Length: 37  Bit Score: 70.70  E-value: 6.97e-15
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 341940690    76 RRGQQEILRGPNVCGSRFHSYCCPGWKTLPGGNQCIV 112
Cdd:pfam18193    1 RRGGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1741-1784 1.53e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 61.14  E-value: 1.53e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 341940690  1741 TCENELPFNVTKRMCCCTYnVGKAWNKPCEPCPTPGTADFKTIC 1784
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTS-VGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 706-749 6.71e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 56.52  E-value: 6.71e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 341940690   706 GVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLC 749
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2104-2148 2.07e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 2.07e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 341940690  2104 GKCSVPKAFNTTKAKCCCSKMpGEGWGDPCELCPKDDEVAFQDLC 2148
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSV-GRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1003-1045 1.07e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 53.05  E-value: 1.07e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 341940690  1003 DECIHPVPGKFRMDACCCA-VGAAWGTECEECPKPGTKEYETLC 1045
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1405-1440 1.77e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 52.22  E-value: 1.77e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 341940690  1405 CANGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTC 1440
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2387-2430 6.00e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 51.12  E-value: 6.00e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 341940690  2387 MCQMASSSRnlVTKSECCCD-GGRGWGHQCELCPLPGTAQYKKIC 2430
Cdd:pfam00683    2 RCSNPLPGN--VTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1586-1626 1.73e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 49.58  E-value: 1.73e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 341940690  1586 CNTEVGVGVSRSSCCC-SLGKAWGNPCETCPPVNSTEYYTLC 1626
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 373-417 3.40e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 3.40e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 341940690   373 GRCAQELPGRMAKAQCCCE-PGRCWsiGTIPEACPVRGSEEYRRLC 417
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAW--GSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1364-1399 5.35e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.28  E-value: 5.35e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 341940690  1364 CEIGAHNCDMHASCLNVPGSFKCSCREGWVGNGIKC 1399
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1239-1274 1.31e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 1.31e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 341940690  1239 CMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC 1274
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
2206-2245 4.30e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 4.30e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 341940690   2206 DTDECSIGNPCGNG-TCTNVIGSFECTCNEGFEPGpmMNCE 2245
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2488-2523 5.53e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.23  E-value: 5.53e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 341940690  2488 CSQSPKPCNFICKNTKGSYQCSCPRGYVLQEDGKTC 2523
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1843-1875 1.29e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 1.29e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 341940690   1843 DIDECSNGdNLCQRNADCINSPGSYRCECAAGF 1875
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
651-691 1.53e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.53e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 341940690    651 DVDECQTPGICMNG-HCINNEGSFRCDCPPGLavgVDGRVCV 691
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1927-1961 1.80e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.80e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 341940690   1927 DVDECE-RHPCGNG-TCKNTVGSYNCLCYPGFELTHN 1961
Cdd:smart00179    1 DIDECAsGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2482-2522 1.91e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 45.45  E-value: 1.91e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 341940690 2482 CVDLDECSQSPKPCNFICKNTKGSYQCSCPRGYVLQEDGKT 2522
Cdd:cd01475   184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1401-1436 2.16e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 2.16e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 341940690 1401 DLDECANGtHQCSINAQCVNTPGSYRCACSEGFTGD 1436
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1843-1877 2.27e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 2.27e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 341940690 1843 DIDECSNGdNLCQRNADCINSPGSYRCECAAGFKL 1877
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 898-928 2.51e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 40.72  E-value: 2.51e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 341940690   898 NRCEVNINGATLKSECC-ATLGAAWGSPCERC 928
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCcTSVGRAWGSPCELC 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2164-2205 2.62e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.62e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 341940690   2164 DVNEClESPGICSNG-QCINTDGSFRCECPMGYnldYTGVRCV 2205
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
528-558 2.84e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 2.84e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 341940690    528 DVDECTS-NPCSNG-DCVNTPGSYYCKCHAGFQ 558
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1927-1960 2.90e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 2.90e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 341940690 1927 DVDECE-RHPCGN-GTCKNTVGSYNCLCYPGFELTH 1960
Cdd:cd00054     1 DIDECAsGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
568-609 3.59e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.59e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 341940690    568 DIDECIQNGVLCKNGRCVNTDGSFQCICNAGFeltTDGKNCV 609
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1401-1440 4.00e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 4.00e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 341940690   1401 DLDECANGtHQCSINAQCVNTPGSYRCACSEGFTgDGFTC 1440
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 651-680 4.18e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 4.18e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 341940690  651 DVDECQTPGICMNGH-CINNEGSFRCDCPPG 680
Cdd:cd00054     1 DIDECASGNPCQNGGtCVNTVGSYRCSCPPG 31
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1233-1273 4.98e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 44.30  E-value: 4.98e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 341940690 1233 CTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRS 1273
Cdd:cd01475   184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2206-2237 5.03e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 5.03e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 341940690 2206 DTDECSIGNPCGN-GTCTNVIGSFECTCNEGFE 2237
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1643-1675 5.75e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 5.75e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 341940690   1643 DIDECQELPGLCQGGNCINTFGSFQCECPQGYY 1675
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 803-838 6.44e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 6.44e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 341940690  803 DIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRT 838
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1151-1183 7.65e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 7.65e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 341940690   1151 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHE 1183
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1151-1184 9.35e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 9.35e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 341940690 1151 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHEL 1184
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
2049-2089 9.50e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 9.50e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 341940690   2049 DINECdEDPNICLFGS-CTNTPGGFQCICPPGFVlsdNGRRC 2089
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA pfam07645
Calcium-binding EGF domain;
1843-1874 9.76e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 9.76e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 341940690  1843 DIDECSNGDNLCQRNADCINSPGSYRCECAAG 1874
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2821-2868 1.12e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 40.76  E-value: 1.12e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 341940690 2821 EPLNNHIRYVISQGNEDGVFRIHQRNGLsyLHTaKKKL---APGTYTLEIT 2868
Cdd:cd11304    26 SGENGEVTYSIVSGNEDGLFSIDPSTGE--ITT-AKPLdreEQSSYTLTVT 73
EGF_CA smart00179
Calcium-binding EGF-like domain;
1108-1142 1.22e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.22e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 341940690   1108 DIDECRiSPDLCGSG-ICVNTPGSFECECFEGYESG 1142
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
1966-2008 1.29e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.29e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 341940690   1966 DIDECSSffGQVCRNG-RCFNEIGSFKCLCNEGYEltpDGKNCI 2008
Cdd:smart00179    1 DIDECAS--GNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 528-558 1.32e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.32e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 341940690  528 DVDECTS-NPCSN-GDCVNTPGSYYCKCHAGFQ 558
Cdd:cd00054     1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
803-834 1.39e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.39e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 341940690    803 DIDECLVNRLLCDNGLCRNTPGSYSCTCPPGY 834
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
610-650 1.39e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.39e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 341940690    610 DHDECTTTNMCLNG-MCINEDGSFKCVCKPGFIlapNGRYCT 650
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
2607-2636 1.49e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.49e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 341940690   2607 DVDECDGNHRCQHG--CQNILGGYRCGCPQGY 2636
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2164-2205 1.53e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.53e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 341940690 2164 DVNEClESPGICSN-GQCINTDGSFRCECPMGynldYTGVRCV 2205
Cdd:cd00054     1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPG----YTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1525-1556 1.55e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.55e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 341940690   1525 DIDECADPINCVNG-LCVNTPGRYECNCPPDFQ 1556
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
2525-2554 1.61e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.61e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 341940690  2525 DLDECQTKQHNCQ--FLCVNTLGGFTCKCPPG 2554
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1193-1225 1.72e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.72e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 341940690   1193 DINECSlSDNLCRNG-KCVNMIGTYQCSCNPGYQ 1225
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 568-603 1.79e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.79e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 341940690  568 DIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTT 603
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2520-2556 1.90e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 42.37  E-value: 1.90e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 341940690 2520 GKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFT 2556
Cdd:cd01475   181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYA 217
EGF_CA smart00179
Calcium-binding EGF-like domain;
1801-1833 2.01e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.01e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 341940690   1801 DIDECKEiPGICANG-VCINQIGSFRCECPTGFS 1833
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1643-1676 2.14e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.14e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 341940690 1643 DIDECQELPGLCQGGNCINTFGSFQCECPQGYYL 1676
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 610-642 2.31e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 341940690  610 DHDECTTTNMCLN-GMCINEDGSFKCVCKPGFIL 642
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1880-1922 2.34e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 41.99  E-value: 2.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 341940690 1880 NGACVDRNECLEIPNVCSHGlCVDLQGSYQCICNNGFKASQDQ 1922
Cdd:cd01475   181 GKICVVPDLCATLSHVCQQV-CISTPGSYLCACTEGYALLEDN 222
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1360-1394 2.55e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 2.55e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 341940690 1360 DVDECEIGaHNCDMHASCLNVPGSFKCSCREGWVG 1394
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
Cadherin pfam00028
Cadherin domain;
2821-2867 2.75e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.21  E-value: 2.75e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 341940690  2821 EPLNNHIRYVISQGNEDGVFRIHQRNGLsyLHTAK--KKLAPGTYTLEI 2867
Cdd:pfam00028   25 LGPNGRIFYSILGGGPGGNFRIDPDTGD--ISTTKplDRESIGEYELTV 71
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2821-2868 3.55e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.87  E-value: 3.55e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 341940690   2821 EPLNNHIRYVISQGNEDGVFRIHQRNGlsyLHTAKKKL---APGTYTLEIT 2868
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETG---EITTTKPLdreEQPEYTLTVE 54
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2049-2082 4.09e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 4.09e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 341940690 2049 DINECdEDPNICLF-GSCTNTPGGFQCICPPGFVL 2082
Cdd:cd00054     1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
761-802 4.50e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 4.50e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 341940690    761 DINECAlDPDICANG-ICENLRGSYRCNCNSGYEpdaSGRNCI 802
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
948-978 4.94e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 4.94e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 341940690   948 DVNECEVFPGVCP-NGRCVNSKGSFHCECPEG 978
Cdd:pfam07645    1 DVDECATGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1525-1557 5.24e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 5.24e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 341940690 1525 DIDECADPINCVN-GLCVNTPGRYECNCPPDFQL 1557
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
276-306 5.27e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.27e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 341940690    276 DVDECqAIPGLCQ-GGNCINTVGSFECRCPAG 306
Cdd:smart00179    1 DIDEC-ASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1484-1519 5.70e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.70e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 341940690   1484 DIDECSFQNICVFG-TCNNLPGMFHCICDDGYELDRT 1519
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1193-1225 5.78e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 5.78e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 341940690 1193 DINECSlSDNLCRN-GKCVNMIGTYQCSCNPGYQ 1225
Cdd:cd00054     1 DIDECA-SGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
2164-2194 5.78e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 5.78e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 341940690  2164 DVNECLESPGIC-SNGQCINTDGSFRCECPMG 2194
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1108-1138 6.26e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 6.26e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 341940690  1108 DIDECRISPDLC-GSGICVNTPGSFECECFEG 1138
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2442-2475 6.29e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 6.29e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 341940690   2442 DIDECKvMPSLCTNG-QCVNTMGSFRCFCKVGYTT 2475
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2607-2636 6.76e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.76e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 341940690 2607 DVDECDGNHRCQHG--CQNILGGYRCGCPQGY 2636
Cdd:cd00054     1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1484-1518 6.90e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.90e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 341940690 1484 DIDECSFQNICVF-GTCNNLPGMFHCICDDGYELDR 1518
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 224-257 7.21e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.49  E-value: 7.21e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 341940690   224 MCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQ 257
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPP 35
EGF_CA pfam07645
Calcium-binding EGF domain;
2287-2319 7.40e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 7.40e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 341940690  2287 DLDECAEGLHDCeSRGMMCKNLIGTFMCICPPG 2319
Cdd:pfam07645    1 DVDECATGTHNC-PANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2009-2041 7.74e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.74e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 341940690   2009 DTNECvALPGSCSPG-TCQNLEGSFRCICPPGYE 2041
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1801-1833 8.00e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 8.00e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 341940690 1801 DIDECKEIPGICANGVCINQIGSFRCECPTGFS 1833
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
1801-1831 8.08e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 8.08e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 341940690  1801 DIDECKEIPGIC-ANGVCINQIGSFRCECPTG 1831
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1360-1392 8.21e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 8.21e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 341940690   1360 DVDECEIGaHNCDMHASCLNVPGSFKCSCREGW 1392
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2564-2606 8.29e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 8.29e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 341940690   2564 DNNECgSQPSLCGAKGICQNTPGSFSCECQRGFSldaSGLNCE 2606
Cdd:smart00179    1 DIDEC-ASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
 
Name Accession Description Interval E-value
Fibrillin_U_N pfam18193
Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. ...
 76-112 6.97e-15

Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.


Pssm-ID: 436338  Cd Length: 37  Bit Score: 70.70  E-value: 6.97e-15
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 341940690    76 RRGQQEILRGPNVCGSRFHSYCCPGWKTLPGGNQCIV 112
Cdd:pfam18193    1 RRGGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1741-1784 1.53e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 61.14  E-value: 1.53e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 341940690  1741 TCENELPFNVTKRMCCCTYnVGKAWNKPCEPCPTPGTADFKTIC 1784
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTS-VGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 706-749 6.71e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 56.52  E-value: 6.71e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 341940690   706 GVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLC 749
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2104-2148 2.07e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 2.07e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 341940690  2104 GKCSVPKAFNTTKAKCCCSKMpGEGWGDPCELCPKDDEVAFQDLC 2148
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSV-GRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1003-1045 1.07e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 53.05  E-value: 1.07e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 341940690  1003 DECIHPVPGKFRMDACCCA-VGAAWGTECEECPKPGTKEYETLC 1045
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1405-1440 1.77e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 52.22  E-value: 1.77e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 341940690  1405 CANGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTC 1440
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2387-2430 6.00e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 51.12  E-value: 6.00e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 341940690  2387 MCQMASSSRnlVTKSECCCD-GGRGWGHQCELCPLPGTAQYKKIC 2430
Cdd:pfam00683    2 RCSNPLPGN--VTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1586-1626 1.73e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 49.58  E-value: 1.73e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 341940690  1586 CNTEVGVGVSRSSCCC-SLGKAWGNPCETCPPVNSTEYYTLC 1626
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 373-417 3.40e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 3.40e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 341940690   373 GRCAQELPGRMAKAQCCCE-PGRCWsiGTIPEACPVRGSEEYRRLC 417
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAW--GSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1364-1399 5.35e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.28  E-value: 5.35e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 341940690  1364 CEIGAHNCDMHASCLNVPGSFKCSCREGWVGNGIKC 1399
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1239-1274 1.31e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 1.31e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 341940690  1239 CMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC 1274
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
2206-2245 4.30e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 4.30e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 341940690   2206 DTDECSIGNPCGNG-TCTNVIGSFECTCNEGFEPGpmMNCE 2245
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1360-1391 4.34e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 4.34e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 341940690  1360 DVDECEIGAHNCDMHASCLNVPGSFKCSCREG 1391
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1401-1432 4.51e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 4.51e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 341940690  1401 DLDECANGTHQCSINAQCVNTPGSYRCACSEG 1432
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2488-2523 5.53e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.23  E-value: 5.53e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 341940690  2488 CSQSPKPCNFICKNTKGSYQCSCPRGYVLQEDGKTC 2523
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1843-1875 1.29e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 1.29e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 341940690   1843 DIDECSNGdNLCQRNADCINSPGSYRCECAAGF 1875
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
651-691 1.53e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.53e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 341940690    651 DVDECQTPGICMNG-HCINNEGSFRCDCPPGLavgVDGRVCV 691
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1927-1961 1.80e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.80e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 341940690   1927 DVDECE-RHPCGNG-TCKNTVGSYNCLCYPGFELTHN 1961
Cdd:smart00179    1 DIDECAsGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2482-2522 1.91e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 45.45  E-value: 1.91e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 341940690 2482 CVDLDECSQSPKPCNFICKNTKGSYQCSCPRGYVLQEDGKT 2522
Cdd:cd01475   184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1401-1436 2.16e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 2.16e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 341940690 1401 DLDECANGtHQCSINAQCVNTPGSYRCACSEGFTGD 1436
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1843-1877 2.27e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 2.27e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 341940690 1843 DIDECSNGdNLCQRNADCINSPGSYRCECAAGFKL 1877
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 898-928 2.51e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 40.72  E-value: 2.51e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 341940690   898 NRCEVNINGATLKSECC-ATLGAAWGSPCERC 928
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCcTSVGRAWGSPCELC 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2164-2205 2.62e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.62e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 341940690   2164 DVNEClESPGICSNG-QCINTDGSFRCECPMGYnldYTGVRCV 2205
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
528-558 2.84e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 2.84e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 341940690    528 DVDECTS-NPCSNG-DCVNTPGSYYCKCHAGFQ 558
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1927-1960 2.90e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 2.90e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 341940690 1927 DVDECE-RHPCGN-GTCKNTVGSYNCLCYPGFELTH 1960
Cdd:cd00054     1 DIDECAsGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
568-609 3.59e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.59e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 341940690    568 DIDECIQNGVLCKNGRCVNTDGSFQCICNAGFeltTDGKNCV 609
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1401-1440 4.00e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 4.00e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 341940690   1401 DLDECANGtHQCSINAQCVNTPGSYRCACSEGFTgDGFTC 1440
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 651-680 4.18e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 4.18e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 341940690  651 DVDECQTPGICMNGH-CINNEGSFRCDCPPG 680
Cdd:cd00054     1 DIDECASGNPCQNGGtCVNTVGSYRCSCPPG 31
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1233-1273 4.98e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 44.30  E-value: 4.98e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 341940690 1233 CTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRS 1273
Cdd:cd01475   184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2206-2237 5.03e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 5.03e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 341940690 2206 DTDECSIGNPCGN-GTCTNVIGSFECTCNEGFE 2237
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1643-1675 5.75e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 5.75e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 341940690   1643 DIDECQELPGLCQGGNCINTFGSFQCECPQGYY 1675
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1399-1434 6.14e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 43.91  E-value: 6.14e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 341940690 1399 CIDLDECANGTHQCsinAQ-CVNTPGSYRCACSEGFT 1434
Cdd:cd01475   184 CVVPDLCATLSHVC---QQvCISTPGSYLCACTEGYA 217
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 803-838 6.44e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 6.44e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 341940690  803 DIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRT 838
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1840-1881 6.91e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 43.91  E-value: 6.91e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 341940690 1840 VCEDIDECSNGDNLCQRNadCINSPGSYRCECAAGFKLSPNG 1881
Cdd:cd01475   183 ICVVPDLCATLSHVCQQV--CISTPGSYLCACTEGYALLEDN 222
EGF_CA smart00179
Calcium-binding EGF-like domain;
1151-1183 7.65e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 7.65e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 341940690   1151 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHE 1183
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1151-1184 9.35e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 9.35e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 341940690 1151 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHEL 1184
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
2049-2089 9.50e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 9.50e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 341940690   2049 DINECdEDPNICLFGS-CTNTPGGFQCICPPGFVlsdNGRRC 2089
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA pfam07645
Calcium-binding EGF domain;
1843-1874 9.76e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 9.76e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 341940690  1843 DIDECSNGDNLCQRNADCINSPGSYRCECAAG 1874
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2821-2868 1.12e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 40.76  E-value: 1.12e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 341940690 2821 EPLNNHIRYVISQGNEDGVFRIHQRNGLsyLHTaKKKL---APGTYTLEIT 2868
Cdd:cd11304    26 SGENGEVTYSIVSGNEDGLFSIDPSTGE--ITT-AKPLdreEQSSYTLTVT 73
EGF_CA smart00179
Calcium-binding EGF-like domain;
1108-1142 1.22e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.22e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 341940690   1108 DIDECRiSPDLCGSG-ICVNTPGSFECECFEGYESG 1142
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
1966-2008 1.29e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.29e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 341940690   1966 DIDECSSffGQVCRNG-RCFNEIGSFKCLCNEGYEltpDGKNCI 2008
Cdd:smart00179    1 DIDECAS--GNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 528-558 1.32e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.32e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 341940690  528 DVDECTS-NPCSN-GDCVNTPGSYYCKCHAGFQ 558
Cdd:cd00054     1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
803-834 1.39e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.39e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 341940690    803 DIDECLVNRLLCDNGLCRNTPGSYSCTCPPGY 834
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
610-650 1.39e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.39e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 341940690    610 DHDECTTTNMCLNG-MCINEDGSFKCVCKPGFIlapNGRYCT 650
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
2607-2636 1.49e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.49e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 341940690   2607 DVDECDGNHRCQHG--CQNILGGYRCGCPQGY 2636
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2164-2205 1.53e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.53e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 341940690 2164 DVNEClESPGICSN-GQCINTDGSFRCECPMGynldYTGVRCV 2205
Cdd:cd00054     1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPG----YTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1525-1556 1.55e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.55e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 341940690   1525 DIDECADPINCVNG-LCVNTPGRYECNCPPDFQ 1556
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
2525-2554 1.61e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.61e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 341940690  2525 DLDECQTKQHNCQ--FLCVNTLGGFTCKCPPG 2554
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1193-1225 1.72e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.72e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 341940690   1193 DINECSlSDNLCRNG-KCVNMIGTYQCSCNPGYQ 1225
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 568-603 1.79e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.79e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 341940690  568 DIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTT 603
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2520-2556 1.90e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 42.37  E-value: 1.90e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 341940690 2520 GKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFT 2556
Cdd:cd01475   181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYA 217
EGF_CA smart00179
Calcium-binding EGF-like domain;
1801-1833 2.01e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.01e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 341940690   1801 DIDECKEiPGICANG-VCINQIGSFRCECPTGFS 1833
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1643-1676 2.14e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.14e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 341940690 1643 DIDECQELPGLCQGGNCINTFGSFQCECPQGYYL 1676
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 610-642 2.31e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 341940690  610 DHDECTTTNMCLN-GMCINEDGSFKCVCKPGFIL 642
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1880-1922 2.34e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 41.99  E-value: 2.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 341940690 1880 NGACVDRNECLEIPNVCSHGlCVDLQGSYQCICNNGFKASQDQ 1922
Cdd:cd01475   181 GKICVVPDLCATLSHVCQQV-CISTPGSYLCACTEGYALLEDN 222
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1360-1394 2.55e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 2.55e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 341940690 1360 DVDECEIGaHNCDMHASCLNVPGSFKCSCREGWVG 1394
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
Cadherin pfam00028
Cadherin domain;
2821-2867 2.75e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.21  E-value: 2.75e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 341940690  2821 EPLNNHIRYVISQGNEDGVFRIHQRNGLsyLHTAK--KKLAPGTYTLEI 2867
Cdd:pfam00028   25 LGPNGRIFYSILGGGPGGNFRIDPDTGD--ISTTKplDRESIGEYELTV 71
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2821-2868 3.55e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.87  E-value: 3.55e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 341940690   2821 EPLNNHIRYVISQGNEDGVFRIHQRNGlsyLHTAKKKL---APGTYTLEIT 2868
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETG---EITTTKPLdreEQPEYTLTVE 54
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2049-2082 4.09e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 4.09e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 341940690 2049 DINECdEDPNICLF-GSCTNTPGGFQCICPPGFVL 2082
Cdd:cd00054     1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
761-802 4.50e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 4.50e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 341940690    761 DINECAlDPDICANG-ICENLRGSYRCNCNSGYEpdaSGRNCI 802
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
948-978 4.94e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 4.94e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 341940690   948 DVNECEVFPGVCP-NGRCVNSKGSFHCECPEG 978
Cdd:pfam07645    1 DVDECATGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1525-1557 5.24e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 5.24e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 341940690 1525 DIDECADPINCVN-GLCVNTPGRYECNCPPDFQL 1557
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
276-306 5.27e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.27e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 341940690    276 DVDECqAIPGLCQ-GGNCINTVGSFECRCPAG 306
Cdd:smart00179    1 DIDEC-ASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1484-1519 5.70e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.70e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 341940690   1484 DIDECSFQNICVFG-TCNNLPGMFHCICDDGYELDRT 1519
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1193-1225 5.78e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 5.78e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 341940690 1193 DINECSlSDNLCRN-GKCVNMIGTYQCSCNPGYQ 1225
Cdd:cd00054     1 DIDECA-SGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
2164-2194 5.78e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 5.78e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 341940690  2164 DVNECLESPGIC-SNGQCINTDGSFRCECPMG 2194
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1108-1138 6.26e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 6.26e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 341940690  1108 DIDECRISPDLC-GSGICVNTPGSFECECFEG 1138
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2442-2475 6.29e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 6.29e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 341940690   2442 DIDECKvMPSLCTNG-QCVNTMGSFRCFCKVGYTT 2475
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2607-2636 6.76e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.76e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 341940690 2607 DVDECDGNHRCQHG--CQNILGGYRCGCPQGY 2636
Cdd:cd00054     1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1484-1518 6.90e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.90e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 341940690 1484 DIDECSFQNICVF-GTCNNLPGMFHCICDDGYELDR 1518
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 224-257 7.21e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.49  E-value: 7.21e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 341940690   224 MCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQ 257
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPP 35
EGF_CA pfam07645
Calcium-binding EGF domain;
2287-2319 7.40e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 7.40e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 341940690  2287 DLDECAEGLHDCeSRGMMCKNLIGTFMCICPPG 2319
Cdd:pfam07645    1 DVDECATGTHNC-PANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2009-2041 7.74e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.74e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 341940690   2009 DTNECvALPGSCSPG-TCQNLEGSFRCICPPGYE 2041
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1801-1833 8.00e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 8.00e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 341940690 1801 DIDECKEIPGICANGVCINQIGSFRCECPTGFS 1833
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
1801-1831 8.08e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 8.08e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 341940690  1801 DIDECKEIPGIC-ANGVCINQIGSFRCECPTG 1831
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 2507-2528 8.08e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.85  E-value: 8.08e-03
                           10        20
                   ....*....|....*....|..
gi 341940690  2507 QCSCPRGYVLQEDGKTCKDLDE 2528
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF_CA smart00179
Calcium-binding EGF-like domain;
1360-1392 8.21e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 8.21e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 341940690   1360 DVDECEIGaHNCDMHASCLNVPGSFKCSCREGW 1392
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2564-2606 8.29e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 8.29e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 341940690   2564 DNNECgSQPSLCGAKGICQNTPGSFSCECQRGFSldaSGLNCE 2606
Cdd:smart00179    1 DIDEC-ASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1358-1393 8.41e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.45  E-value: 8.41e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 341940690 1358 CTDVDECEIGAHNCDmHAsCLNVPGSFKCSCREGWV 1393
Cdd:cd01475   184 CVVPDLCATLSHVCQ-QV-CISTPGSYLCACTEGYA 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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