NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|82241885|sp|Q803V5|]
View 

RecName: Full=Target of rapamycin complex subunit lst8; Short=TORC subunit lst8; AltName: Full=G protein beta subunit-like; Short=Gable; Short=Protein GbetaL; AltName: Full=MTOR associated protein, LST8 homolog

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-320 1.43e-61

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 201.29  E-value: 1.43e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885   3 VNQGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNSLEVTPDRSMIAAAGYQH-IRMYDLNSNNPNPVINy 81
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGtVRLWDLATGKLLRTLT- 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885  82 dGVSKNITSVGFHEDGRWMYTGGEDCMARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGVIHIWDLKTD 160
Cdd:COG2319 160 -GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885 161 HNEQLIPEPDVSVNSVHIDPDASYMAAVNSSGNCYVWNLAGGMgdevtqliPKTKIPAHKRYSLRCKFSPDSTLLATCSA 240
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE--------LLRTLTGHSGGVNSVAFSPDGKLLASGSD 308

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885 241 DQTCKIWRTSNFSLMTELSiksnnpGETsrGWMWDCAFSGDSQYIVTASSDNLARLWCVETGEIKREYSGHQKAVVCLAF 320
Cdd:COG2319 309 DGTVRLWDLATGKLLRTLT------GHT--GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-320 1.43e-61

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 201.29  E-value: 1.43e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885   3 VNQGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNSLEVTPDRSMIAAAGYQH-IRMYDLNSNNPNPVINy 81
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGtVRLWDLATGKLLRTLT- 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885  82 dGVSKNITSVGFHEDGRWMYTGGEDCMARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGVIHIWDLKTD 160
Cdd:COG2319 160 -GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885 161 HNEQLIPEPDVSVNSVHIDPDASYMAAVNSSGNCYVWNLAGGMgdevtqliPKTKIPAHKRYSLRCKFSPDSTLLATCSA 240
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE--------LLRTLTGHSGGVNSVAFSPDGKLLASGSD 308

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885 241 DQTCKIWRTSNFSLMTELSiksnnpGETsrGWMWDCAFSGDSQYIVTASSDNLARLWCVETGEIKREYSGHQKAVVCLAF 320
Cdd:COG2319 309 DGTVRLWDLATGKLLRTLT------GHT--GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-297 9.08e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 151.72  E-value: 9.08e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885  14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNSLEVTPDRSMIAAAGYQH-IRMYDLNSNNPnpVINYDGVSKNITSVG 92
Cdd:cd00200  23 LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKtIRLWDLETGEC--VRTLTGHTSYVSSVA 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885  93 FHEDGRWMYTGGEDCMARIWDLRSRnlQCQRIFQ-VNAPINCVCLHPNQAELIVGDQSGVIHIWDLKTDHNEQLIPEPDV 171
Cdd:cd00200 101 FSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885 172 SVNSVHIDPDASYMAAVNSSGNCYVWNLAggMGDEVTQLIpktkipAHKRYSLRCKFSPDSTLLATCSADQTCKIWRTSN 251
Cdd:cd00200 179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLS--TGKCLGTLR------GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 82241885 252 FSLMTELSiksnnpGETSRGWmwDCAFSGDSQYIVTASSDNLARLW 297
Cdd:cd00200 251 GECVQTLS------GHTNSVT--SLAWSPDGKRLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 212-247 5.73e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 5.73e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 82241885    212 PKTKIPAHKRYSLRCKFSPDSTLLATCSADQTCKIW 247
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
76-113 7.52e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 7.52e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 82241885    76 NPVINYDGVSKNITSVGFHEDGRWMYTGGEDCMARIWD 113
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-320 1.43e-61

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 201.29  E-value: 1.43e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885   3 VNQGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNSLEVTPDRSMIAAAGYQH-IRMYDLNSNNPNPVINy 81
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGtVRLWDLATGKLLRTLT- 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885  82 dGVSKNITSVGFHEDGRWMYTGGEDCMARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGVIHIWDLKTD 160
Cdd:COG2319 160 -GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885 161 HNEQLIPEPDVSVNSVHIDPDASYMAAVNSSGNCYVWNLAGGMgdevtqliPKTKIPAHKRYSLRCKFSPDSTLLATCSA 240
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE--------LLRTLTGHSGGVNSVAFSPDGKLLASGSD 308

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885 241 DQTCKIWRTSNFSLMTELSiksnnpGETsrGWMWDCAFSGDSQYIVTASSDNLARLWCVETGEIKREYSGHQKAVVCLAF 320
Cdd:COG2319 309 DGTVRLWDLATGKLLRTLT------GHT--GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
WD40 COG2319
WD40 repeat [General function prediction only];
14-297 1.90e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 180.11  E-value: 1.90e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885  14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNSLEVTPDRSMIAAAGYQH-IRMYDLNSNNPnpVINYDGVSKNITSVG 92
Cdd:COG2319 134 TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGtVRLWDLATGKL--LRTLTGHTGAVRSVA 211

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885  93 FHEDGRWMYTGGEDCMARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGVIHIWDLKTDHNEQLIPEPDV 171
Cdd:COG2319 212 FSPDGKLLASGSADGTVRLWDLATG--KLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG 289

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885 172 SVNSVHIDPDASYMAAVNSSGNCYVWNLAGGmgdevtQLIpkTKIPAHKRYSLRCKFSPDSTLLATCSADQTCKIWRTSN 251
Cdd:COG2319 290 GVNSVAFSPDGKLLASGSDDGTVRLWDLATG------KLL--RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 82241885 252 FSLMTELSiksnnpGETsrGWMWDCAFSGDSQYIVTASSDNLARLW 297
Cdd:COG2319 362 GELLRTLT------GHT--GAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
10-320 9.79e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 175.87  E-value: 9.79e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNSLEVTPDRSMIAAAGYQH-IRMYDLNSNNPNPVINydGVSKNI 88
Cdd:COG2319  46 PDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGtVRLWDLATGLLLRTLT--GHTGAV 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885  89 TSVGFHEDGRWMYTGGEDCMARIWDLRSRNLQcQRIFQVNAPINCVCLHPNQAELIVGDQSGVIHIWDLKTDHNEQLIPE 168
Cdd:COG2319 124 RSVAFSPDGKTLASGSADGTVRLWDLATGKLL-RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885 169 PDVSVNSVHIDPDASYMAAVNSSGNCYVWNLAGGmgdevtQLIpkTKIPAHKRYSLRCKFSPDSTLLATCSADQTCKIWR 248
Cdd:COG2319 203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG------KLL--RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 82241885 249 TSNFSLMTELSIKSnnpgetsrGWMWDCAFSGDSQYIVTASSDNLARLWCVETGEIKREYSGHQKAVVCLAF 320
Cdd:COG2319 275 LATGELLRTLTGHS--------GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-297 9.08e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 151.72  E-value: 9.08e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885  14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNSLEVTPDRSMIAAAGYQH-IRMYDLNSNNPnpVINYDGVSKNITSVG 92
Cdd:cd00200  23 LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKtIRLWDLETGEC--VRTLTGHTSYVSSVA 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885  93 FHEDGRWMYTGGEDCMARIWDLRSRnlQCQRIFQ-VNAPINCVCLHPNQAELIVGDQSGVIHIWDLKTDHNEQLIPEPDV 171
Cdd:cd00200 101 FSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885 172 SVNSVHIDPDASYMAAVNSSGNCYVWNLAggMGDEVTQLIpktkipAHKRYSLRCKFSPDSTLLATCSADQTCKIWRTSN 251
Cdd:cd00200 179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLS--TGKCLGTLR------GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 82241885 252 FSLMTELSiksnnpGETSRGWmwDCAFSGDSQYIVTASSDNLARLW 297
Cdd:cd00200 251 GECVQTLS------GHTNSVT--SLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
14-251 1.77e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.91  E-value: 1.77e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885  14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNSLEVTPDRSMIAAAGYQH-IRMYDLNSnnPNPVINYDGVSKNITSVG 92
Cdd:COG2319 176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGtVRLWDLAT--GKLLRTLTGHSGSVRSVA 253

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885  93 FHEDGRWMYTGGEDCMARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGVIHIWDLKTDHNEQLIPEPDV 171
Cdd:COG2319 254 FSPDGRLLASGSADGTVRLWDLATG--ELLRTLTGhSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 331

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885 172 SVNSVHIDPDASYMAAVNSSGNCYVWNLAGGmgdevtqlIPKTKIPAHKRYSLRCKFSPDSTLLATCSADQTCKIWRTSN 251
Cdd:COG2319 332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATG--------ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-248 1.48e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.55  E-value: 1.48e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885  15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNSLEVTPDRSMIAAAGYQH-IRMYDLNSNNPnpVINYDGVSKNITSVGF 93
Cdd:cd00200  66 LASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKtIKVWDVETGKC--LTTLRGHTDWVNSVAF 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885  94 HEDGRWMYTGGEDCMARIWDLRSrnLQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGVIHIWDLKTDHNEQLIPEPDVS 172
Cdd:cd00200 144 SPDGTFVASSSQDGTIKLWDLRT--GKCVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG 221

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 82241885 173 VNSVHIDPDASYMAAVNSSGNCYVWNLAGGmgdevtqlIPKTKIPAHKRYSLRCKFSPDSTLLATCSADQTCKIWR 248
Cdd:cd00200 222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTG--------ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 34-323 9.69e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 138.62  E-value: 9.69e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885  34 CTRTVQHQDSQVNSLEVTPDRSMIAAAGYQH-IRMYDLNSNNPnpVINYDGVSKNITSVGFHEDGRWMYTGGEDCMARIW 112
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGtIKVWDLETGEL--LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885 113 DLRSRNLqCQRIFQVNAPINCVCLHPNQAELIVGDQSGVIHIWDLKTDHNEQLIPEPDVSVNSVHIDPDASYMAAVNSSG 192
Cdd:cd00200  79 DLETGEC-VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885 193 NCYVWNLAGGMgdevtqliPKTKIPAHKRYSLRCKFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSNnpgetsrgW 272
Cdd:cd00200 158 TIKLWDLRTGK--------CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN--------G 221

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 82241885 273 MWDCAFSGDSQYIVTASSDNLARLWCVETGEIKREYSGHQKAVVCLAFNDS 323
Cdd:cd00200 222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPD 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-198 1.44e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.96  E-value: 1.44e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885  14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNSLEVTPDRSMIAAAGY-QHIRMYDLNSNnpNPVINYDGVSKNITSVG 92
Cdd:cd00200 107 ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQdGTIKLWDLRTG--KCVATLTGHTGEVNSVA 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885  93 FHEDGRWMYTGGEDCMARIWDLRSRNLQCQRIFQvNAPINCVCLHPNQAELIVGDQSGVIHIWDLKTDHNEQLIPEPDVS 172
Cdd:cd00200 185 FSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNS 263

                       170       180
                ....*....|....*....|....*.
gi 82241885 173 VNSVHIDPDASYMAAVNSSGNCYVWN 198
Cdd:cd00200 264 VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
92-321 1.94e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 1.94e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885  92 GFHEDGRWMYTGGEDCMARIWDLRSRNLQCQRIFQVNAPINCVcLHPNQAELIVGDQSGVIHIWDLKTDHNEQLIPEPDV 171
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLA-ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885 172 SVNSVHIDPDASYMAAVNSSGNCYVWNLAGGmgdevtqlIPKTKIPAHKRYSLRCKFSPDSTLLATCSADQTCKIWRTSN 251
Cdd:COG2319  80 AVLSVAFSPDGRLLASASADGTVRLWDLATG--------LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885 252 FSLMTELSiksnnpGETsrGWMWDCAFSGDSQYIVTASSDNLARLWCVETGEIKREYSGHQKAVVCLAFN 321
Cdd:COG2319 152 GKLLRTLT------GHS--GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 213
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-156 1.61e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 1.61e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82241885   3 VNQGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNSLEVTPD-RSMIAAAGYQHIRMYDLNSnnPNPVINY 81
Cdd:cd00200 138 VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgEKLLSSSSDGTIKLWDLST--GKCLGTL 215

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 82241885  82 DGVSKNITSVGFHEDGRWMYTGGEDCMARIWDLRSRNLqCQRIFQVNAPINCVCLHPNQAELIVGDQSGVIHIWD 156
Cdd:cd00200 216 RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 212-247 5.73e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 5.73e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 82241885    212 PKTKIPAHKRYSLRCKFSPDSTLLATCSADQTCKIW 247
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
76-113 7.52e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 7.52e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 82241885    76 NPVINYDGVSKNITSVGFHEDGRWMYTGGEDCMARIWD 113
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 74-113 1.36e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.36e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 82241885     74 NPNPVINYDGVSKNITSVGFHEDGRWMYTGGEDCMARIWD 113
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
212-247 2.84e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 2.84e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 82241885   212 PKTKIPAHKRYSLRCKFSPDSTLLATCSADQTCKIW 247
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 270-297 4.36e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 4.36e-03
                           10        20
                   ....*....|....*....|....*...
gi 82241885    270 RGWMWDCAFSGDSQYIVTASSDNLARLW 297
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH