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Conserved domains on  [gi|50401032|sp|Q8BJI4|]
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RecName: Full=POU domain, class 6, transcription factor 2

Protein Classification

POU family transcription factor( domain architecture ID 11036637)

POU (Pit-Oct-Unc) family transcription factor binds specific DNA sequences to direct gene expression programs, playing a role in orchestrating embryonic development and directing cellular fate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pou super family cl22952
Pou domain - N-terminal to homeobox domain;
477-586 6.67e-29

Pou domain - N-terminal to homeobox domain;


The actual alignment was detected with superfamily member smart00352:

Pssm-ID: 473999  Cd Length: 75  Bit Score: 109.84  E-value: 6.67e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50401032    477 DGVNLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICrhtilrshfflpqeaqentiassltaklnpgll 556
Cdd:smart00352   2 DDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTIC--------------------------------- 48

                           90       100       110
                   ....*....|....*....|....*....|
gi 50401032    557 ypaRFEKLDITPKSAQKIKPVLERWMAEAE 586
Cdd:smart00352  49 ---RFEALQLSFKNMCKLKPLLQKWLEEAE 75
Homeodomain pfam00046
Homeodomain;
608-664 2.31e-20

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 84.86  E-value: 2.31e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 50401032   608 RKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALKN 664
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 230-300 1.79e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 45.03  E-value: 1.79e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50401032   230 SQQLPAPPAQLEQATQPQQHQPHSHPQNQTQNQPSPTQQSSSPPQKPSPSPGHSLPSPlTPPNPLQLVNNP 300
Cdd:pfam09770 237 PPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPP-VPVQPTQILQNP 306
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
477-586 6.67e-29

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 109.84  E-value: 6.67e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50401032    477 DGVNLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICrhtilrshfflpqeaqentiassltaklnpgll 556
Cdd:smart00352   2 DDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTIC--------------------------------- 48

                           90       100       110
                   ....*....|....*....|....*....|
gi 50401032    557 ypaRFEKLDITPKSAQKIKPVLERWMAEAE 586
Cdd:smart00352  49 ---RFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
480-586 7.41e-28

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 106.59  E-value: 7.41e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50401032   480 NLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICrhtilrshfflpqeaqentiassltaklnpgllypa 559
Cdd:pfam00157   2 NLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTIC------------------------------------ 45

                          90       100
                  ....*....|....*....|....*..
gi 50401032   560 RFEKLDITPKSAQKIKPVLERWMAEAE 586
Cdd:pfam00157  46 RFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
608-664 2.31e-20

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 84.86  E-value: 2.31e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 50401032   608 RKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALKN 664
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 607-663 1.10e-18

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 79.99  E-value: 1.10e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 50401032    607 KRKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALK 663
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 608-665 4.81e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 75.36  E-value: 4.81e-17
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 50401032 608 RKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALKNT 665
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
601-663 4.10e-09

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 55.91  E-value: 4.10e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 50401032 601 GSEPSKKRKRRTsfTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALK 663
Cdd:COG5576  47 GSSPPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 230-300 1.79e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 45.03  E-value: 1.79e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50401032   230 SQQLPAPPAQLEQATQPQQHQPHSHPQNQTQNQPSPTQQSSSPPQKPSPSPGHSLPSPlTPPNPLQLVNNP 300
Cdd:pfam09770 237 PPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPP-VPVQPTQILQNP 306
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
477-586 6.67e-29

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 109.84  E-value: 6.67e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50401032    477 DGVNLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICrhtilrshfflpqeaqentiassltaklnpgll 556
Cdd:smart00352   2 DDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTIC--------------------------------- 48

                           90       100       110
                   ....*....|....*....|....*....|
gi 50401032    557 ypaRFEKLDITPKSAQKIKPVLERWMAEAE 586
Cdd:smart00352  49 ---RFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
480-586 7.41e-28

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 106.59  E-value: 7.41e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50401032   480 NLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICrhtilrshfflpqeaqentiassltaklnpgllypa 559
Cdd:pfam00157   2 NLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTIC------------------------------------ 45

                          90       100
                  ....*....|....*....|....*..
gi 50401032   560 RFEKLDITPKSAQKIKPVLERWMAEAE 586
Cdd:pfam00157  46 RFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
608-664 2.31e-20

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 84.86  E-value: 2.31e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 50401032   608 RKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALKN 664
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 607-663 1.10e-18

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 79.99  E-value: 1.10e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 50401032    607 KRKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALK 663
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 608-665 4.81e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 75.36  E-value: 4.81e-17
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 50401032 608 RKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALKNT 665
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
601-663 4.10e-09

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 55.91  E-value: 4.10e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 50401032 601 GSEPSKKRKRRTsfTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALK 663
Cdd:COG5576  47 GSSPPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 230-300 1.79e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 45.03  E-value: 1.79e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50401032   230 SQQLPAPPAQLEQATQPQQHQPHSHPQNQTQNQPSPTQQSSSPPQKPSPSPGHSLPSPlTPPNPLQLVNNP 300
Cdd:pfam09770 237 PPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPP-VPVQPTQILQNP 306
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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