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Conserved domains on  [gi|74728484|sp|Q8N131|]
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RecName: Full=Porimin; AltName: Full=Keratinocytes-associated transmembrane protein 3; Short=KCT-3; AltName: Full=Pro-oncosis receptor inducing membrane injury; AltName: Full=Transmembrane protein 123; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MGC-24 super family cl27043
Multi-glycosylated core protein 24 (MGC-24), sialomucin; This family consists of several ...
67-188 2.18e-05

Multi-glycosylated core protein 24 (MGC-24), sialomucin; This family consists of several MGC-24 (or Cd164 antigen) proteins from eukaryotic organizms. MGC-24/CD164 is a sialomucin expressed in many normal and cancerous tissues. In humans, soluble and transmembrane forms of MGC-24 are produced by alternative splicing.


The actual alignment was detected with superfamily member pfam05283:

Pssm-ID: 461610  Cd Length: 140  Bit Score: 42.54  E-value: 2.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74728484    67 SNSTVKPPTSVASDSSNTTVTTMkpTAASNTTTPGMVSTNMTSTTLKSTPkTTSVSQNTSQISTSTMTVThnssvtsaas 146
Cdd:pfam05283  29 EEKSYCSANSTVSDCSVVNRTEF--CSAPHTTTPKPTNSTAKTTTLPSSS-TTSTTVATTGTTNTTLTPT---------- 95
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 74728484   147 svtitttmhSEAKKGSKFDTGSFVGGIVLTLGVLSI---LYIGCK 188
Cdd:pfam05283  96 ---------SQPTHKSTFDAASFIGGIVLVLGLQAViffLYKFCK 131
 
Name Accession Description Interval E-value
MGC-24 pfam05283
Multi-glycosylated core protein 24 (MGC-24), sialomucin; This family consists of several ...
67-188 2.18e-05

Multi-glycosylated core protein 24 (MGC-24), sialomucin; This family consists of several MGC-24 (or Cd164 antigen) proteins from eukaryotic organizms. MGC-24/CD164 is a sialomucin expressed in many normal and cancerous tissues. In humans, soluble and transmembrane forms of MGC-24 are produced by alternative splicing.


Pssm-ID: 461610  Cd Length: 140  Bit Score: 42.54  E-value: 2.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74728484    67 SNSTVKPPTSVASDSSNTTVTTMkpTAASNTTTPGMVSTNMTSTTLKSTPkTTSVSQNTSQISTSTMTVThnssvtsaas 146
Cdd:pfam05283  29 EEKSYCSANSTVSDCSVVNRTEF--CSAPHTTTPKPTNSTAKTTTLPSSS-TTSTTVATTGTTNTTLTPT---------- 95
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 74728484   147 svtitttmhSEAKKGSKFDTGSFVGGIVLTLGVLSI---LYIGCK 188
Cdd:pfam05283  96 ---------SQPTHKSTFDAASFIGGIVLVLGLQAViffLYKFCK 131
PRK11907 PRK11907
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;
66-136 1.11e-04

bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;


Pssm-ID: 237019 [Multi-domain]  Cd Length: 814  Bit Score: 42.53  E-value: 1.11e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74728484   66 TSNSTVKPPTSVASDSSNTTVTTMKPTAASNTTTPgmvSTNMTSTTLKSTPKTTSVSQNTSQISTSTMTVT 136
Cdd:PRK11907  28 AEEIVTTTPATSTEAEQTTPVESDATEEADNTETP---VAATTAAEAPSSSETAETSDPTSEATDTTTSEA 95
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
10-127 6.93e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 37.20  E-value: 6.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74728484   10 AALLLGTLQVLALLGAAHESAAMAASANIENSGlpHNSSANSTETLQHVP-SDHTN----ETSNSTVKPPTSVASDSSNT 84
Cdd:NF033609  19 ASVLVGTLIGFGLLSSKEADASENSVTQSDSAS--NESKSNDSSSVSAAPkTDDTNvsdtKTSSNTNNGETSVAQNPAQQ 96
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 74728484   85 TVTTMKPTAASNTTTPGMVSTNMTSTTLKSTPKTTSVSQNTSQ 127
Cdd:NF033609  97 ETTQSASTNATTEETPVTGEATTTATNQANTPATTQSSNTNAE 139
 
Name Accession Description Interval E-value
MGC-24 pfam05283
Multi-glycosylated core protein 24 (MGC-24), sialomucin; This family consists of several ...
67-188 2.18e-05

Multi-glycosylated core protein 24 (MGC-24), sialomucin; This family consists of several MGC-24 (or Cd164 antigen) proteins from eukaryotic organizms. MGC-24/CD164 is a sialomucin expressed in many normal and cancerous tissues. In humans, soluble and transmembrane forms of MGC-24 are produced by alternative splicing.


Pssm-ID: 461610  Cd Length: 140  Bit Score: 42.54  E-value: 2.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74728484    67 SNSTVKPPTSVASDSSNTTVTTMkpTAASNTTTPGMVSTNMTSTTLKSTPkTTSVSQNTSQISTSTMTVThnssvtsaas 146
Cdd:pfam05283  29 EEKSYCSANSTVSDCSVVNRTEF--CSAPHTTTPKPTNSTAKTTTLPSSS-TTSTTVATTGTTNTTLTPT---------- 95
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 74728484   147 svtitttmhSEAKKGSKFDTGSFVGGIVLTLGVLSI---LYIGCK 188
Cdd:pfam05283  96 ---------SQPTHKSTFDAASFIGGIVLVLGLQAViffLYKFCK 131
PRK11907 PRK11907
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;
66-136 1.11e-04

bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;


Pssm-ID: 237019 [Multi-domain]  Cd Length: 814  Bit Score: 42.53  E-value: 1.11e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74728484   66 TSNSTVKPPTSVASDSSNTTVTTMKPTAASNTTTPgmvSTNMTSTTLKSTPKTTSVSQNTSQISTSTMTVT 136
Cdd:PRK11907  28 AEEIVTTTPATSTEAEQTTPVESDATEEADNTETP---VAATTAAEAPSSSETAETSDPTSEATDTTTSEA 95
FSA_C pfam10479
Fragile site-associated protein C-terminus; This is the conserved C-terminal half of the ...
59-126 2.77e-03

Fragile site-associated protein C-terminus; This is the conserved C-terminal half of the protein KIAA1109 which is the fragile site-associated protein FSA. Genome-wide-association studies showed this protein to linked to the susceptibility to coeliac disease. The protein may also be associated with polycystic kidney disease.


Pssm-ID: 463105  Cd Length: 701  Bit Score: 38.24  E-value: 2.77e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74728484    59 PSDHTNET------SNSTVKPPTSVASDSSNTTVTTmkpTAASNTTTPGMVSTNMTSTTLKSTPKTTSVSQNTS 126
Cdd:pfam10479 534 PSSSTNLTpkqmsaSKSSLEPMQGSYTNIANSTTAN---TATANTTTTTTTTTAATASSTNSTPTTTTTTTSTN 604
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
10-127 6.93e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 37.20  E-value: 6.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74728484   10 AALLLGTLQVLALLGAAHESAAMAASANIENSGlpHNSSANSTETLQHVP-SDHTN----ETSNSTVKPPTSVASDSSNT 84
Cdd:NF033609  19 ASVLVGTLIGFGLLSSKEADASENSVTQSDSAS--NESKSNDSSSVSAAPkTDDTNvsdtKTSSNTNNGETSVAQNPAQQ 96
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 74728484   85 TVTTMKPTAASNTTTPGMVSTNMTSTTLKSTPKTTSVSQNTSQ 127
Cdd:NF033609  97 ETTQSASTNATTEETPVTGEATTTATNQANTPATTQSSNTNAE 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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