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Conserved domains on  [gi|109825594|sp|Q8TEH3|]
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RecName: Full=DENN domain-containing protein 1A; AltName: Full=Connecdenn 1; Short=Connecdenn; AltName: Full=Protein FAM31A

Protein Classification

DENN domain-containing protein( domain architecture ID 10655395)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

CATH:  1.10.287.2550|3.40.50.11500|3.30.450.200
Gene Ontology:  GO:0005085|GO:0032483
PubMed:  21330364|11563850
SCOP:  4007417|4006687

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 95-273 2.28e-64

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214823  Cd Length: 183  Bit Score: 215.14  E-value: 2.28e-64
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594     95 SCFCILSYLPWFEVFYKLLNILADYTTKRQENQwNELLETLHKLPIPDPG-----VSVHLSVHSYFTVPDTRELPSIPen 169
Cdd:smart00799    3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594    170 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 249
Cdd:smart00799   80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159

                           170       180
                    ....*....|....*....|....
gi 109825594    250 HLSLMEKVRNMALDDVVILNVDTN 273
Cdd:smart00799  160 HSSYFEEVKELPDEDVVVVDLDTG 183
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 9-91 1.89e-23

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 95.09  E-value: 1.89e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594      9 PETTFEVYVEVAYPRTGGTLS---DPEVQRQFPE-DYSDQEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQ 82
Cdd:smart00800    1 PSRLFDYFVVVGLDSDTGPLGrsyKPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSR 80


                    ....*....
gi 109825594     83 RFGFCRLSS 91
Cdd:smart00800   81 RYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 305-371 4.94e-17

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 76.17  E-value: 4.94e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594    305 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGR 371
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 644-995 8.54e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.50  E-value: 8.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  644 DDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDSilnpsdkeevptPTLGSITIPRPQGRKTPELGIVPPPPIPRPAK 723
Cdd:PHA03247 2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD------------PAPGRVSRPRRARRLGRAAQASSPPQRPRRRA 2687

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  724 LQAAGAALGDVSErlqtdrdrraALSPGLLPGVVPQgPTELLQPLSPGPGAAGTSSDALLALLDPLSTAwSGSTLPSRPA 803
Cdd:PHA03247 2688 ARPTVGSLTSLAD----------PPPPPPTPEPAPH-ALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPA 2755

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  804 TPNV-ATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPfgaPPASLGPAFASGLLLSSAGFCAPHR 882
Cdd:PHA03247 2756 RPARpPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP---PAAVLAPAAALPPAASPAGPLPPPT 2832

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  883 S-QPNLSALSMPNLFGQMPMGTHTSPLQPL---GPPAVAPSRI--RTLPLARSSARAA--ETKQGLALRPGDPPLLPprp 954
Cdd:PHA03247 2833 SaQPTAPPPPPGPPPPSLPLGGSVAPGGDVrrrPPSRSPAAKPaaPARPPVRRLARPAvsRSTESFALPPDQPERPP--- 2909

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 109825594  955 pqgleptlQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAP 995
Cdd:PHA03247 2910 --------QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 95-273 2.28e-64

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 215.14  E-value: 2.28e-64
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594     95 SCFCILSYLPWFEVFYKLLNILADYTTKRQENQwNELLETLHKLPIPDPG-----VSVHLSVHSYFTVPDTRELPSIPen 169
Cdd:smart00799    3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594    170 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 249
Cdd:smart00799   80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159

                           170       180
                    ....*....|....*....|....
gi 109825594    250 HLSLMEKVRNMALDDVVILNVDTN 273
Cdd:smart00799  160 HSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 96-273 1.86e-44

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 158.89  E-value: 1.86e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594    96 CFCILSYLPWFEVFYKLLNILAdytTKRQENQWNELLET-----LHKLPIPDPGVSVHLSVHS-----YFTVPDTRELPS 165
Cdd:pfam02141    5 AYCIISRLPFFNLFKKFLDELY---RRRTISPLPNPIERfianlLYEVPFPPPGRTQKLKPLGgtepiLLQRPEDSELPL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594   166 ipENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPY 245
Cdd:pfam02141   82 --EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159

                          170       180
                   ....*....|....*....|....*...
gi 109825594   246 LIGIHLSLMEKVRNmALDDVVILNVDTN 273
Cdd:pfam02141  160 IIGVHSRYFDLLED-PLDDVVLVDLDTG 186
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 9-91 1.89e-23

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 95.09  E-value: 1.89e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594      9 PETTFEVYVEVAYPRTGGTLS---DPEVQRQFPE-DYSDQEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQ 82
Cdd:smart00800    1 PSRLFDYFVVVGLDSDTGPLGrsyKPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSR 80


                    ....*....
gi 109825594     83 RFGFCRLSS 91
Cdd:smart00800   81 RYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 305-371 4.94e-17

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 76.17  E-value: 4.94e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594    305 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGR 371
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 31-89 1.75e-11

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 60.32  E-value: 1.75e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594    31 PEVQRQFPE-DYSDQEVLQTLTKFCFPFYVDSLtVSQVGQNFTFVLTDIDSKQRFGFCRL 89
Cdd:pfam03456    1 PEVLDRYPEdDWSDPPLPDGIPMFCFPEGLETL-SSREPTFFSFVLTDEDGSRLYGACLT 59
PHA03247 PHA03247
large tegument protein UL36; Provisional
 644-995 8.54e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.50  E-value: 8.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  644 DDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDSilnpsdkeevptPTLGSITIPRPQGRKTPELGIVPPPPIPRPAK 723
Cdd:PHA03247 2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD------------PAPGRVSRPRRARRLGRAAQASSPPQRPRRRA 2687

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  724 LQAAGAALGDVSErlqtdrdrraALSPGLLPGVVPQgPTELLQPLSPGPGAAGTSSDALLALLDPLSTAwSGSTLPSRPA 803
Cdd:PHA03247 2688 ARPTVGSLTSLAD----------PPPPPPTPEPAPH-ALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPA 2755

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  804 TPNV-ATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPfgaPPASLGPAFASGLLLSSAGFCAPHR 882
Cdd:PHA03247 2756 RPARpPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP---PAAVLAPAAALPPAASPAGPLPPPT 2832

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  883 S-QPNLSALSMPNLFGQMPMGTHTSPLQPL---GPPAVAPSRI--RTLPLARSSARAA--ETKQGLALRPGDPPLLPprp 954
Cdd:PHA03247 2833 SaQPTAPPPPPGPPPPSLPLGGSVAPGGDVrrrPPSRSPAAKPaaPARPPVRRLARPAvsRSTESFALPPDQPERPP--- 2909

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 109825594  955 pqgleptlQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAP 995
Cdd:PHA03247 2910 --------QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 337-388 8.34e-08

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 49.50  E-value: 8.34e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 109825594   337 FCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGRLDLLNsgeGFSDVFEEE 388
Cdd:pfam03455    1 FDKEAFLKS-LPSDSRPFLSQFLETQMFNEFIEERLESSD---PSIDLFDEE 48
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 641-997 2.13e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 2.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594   641 LGQDDMAIPSKPPAASPEKPSALLGNSLALPRRPqnrdsilnPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPR 720
Cdd:pfam03154  167 LQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPT--------PSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLH 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594   721 PAKLQAAGAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPtellQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPS 800
Cdd:pfam03154  239 PQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMP----HSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPS 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594   801 rpatPNVATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTL-PLVSTPAGPFGAPPASLGPAFASGlllsSAGFCA 879
Cdd:pfam03154  315 ----PAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIkPPPTTPIPQLPNPQSHKHPPHLSG----PSPFQM 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594   880 PHRSQPNLSALSMPNLFGQMPMGTHTSPLQ------PLGPPAVAPSRIRTLPLARSSARAAETKQGLALRPGDPPLLPPR 953
Cdd:pfam03154  387 NSNLPPPPALKPLSSLSTHHPPSAHPPPLQlmpqsqQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHP 466

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 109825594   954 PPQGLEPT-LQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAPDS 997
Cdd:pfam03154  467 FVPGGPPPiTPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVS 511
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
754-860 3.84e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 40.89  E-value: 3.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  754 PGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRPATPNVATPFTPQFSFPPAGTPTPFPQPPLNP 833
Cdd:COG3469   108 GTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATA 187

                          90       100
                  ....*....|....*....|....*..
gi 109825594  834 FVPSMPAAPPTLPLVSTPAGPFGAPPA 860
Cdd:COG3469   188 TTASGATTPSATTTATTTGPPTPGLPK 214
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 95-273 2.28e-64

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 215.14  E-value: 2.28e-64
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594     95 SCFCILSYLPWFEVFYKLLNILADYTTKRQENQwNELLETLHKLPIPDPG-----VSVHLSVHSYFTVPDTRELPSIPen 169
Cdd:smart00799    3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594    170 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 249
Cdd:smart00799   80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159

                           170       180
                    ....*....|....*....|....
gi 109825594    250 HLSLMEKVRNMALDDVVILNVDTN 273
Cdd:smart00799  160 HSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 96-273 1.86e-44

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 158.89  E-value: 1.86e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594    96 CFCILSYLPWFEVFYKLLNILAdytTKRQENQWNELLET-----LHKLPIPDPGVSVHLSVHS-----YFTVPDTRELPS 165
Cdd:pfam02141    5 AYCIISRLPFFNLFKKFLDELY---RRRTISPLPNPIERfianlLYEVPFPPPGRTQKLKPLGgtepiLLQRPEDSELPL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594   166 ipENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPY 245
Cdd:pfam02141   82 --EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159

                          170       180
                   ....*....|....*....|....*...
gi 109825594   246 LIGIHLSLMEKVRNmALDDVVILNVDTN 273
Cdd:pfam02141  160 IIGVHSRYFDLLED-PLDDVVLVDLDTG 186
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 9-91 1.89e-23

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 95.09  E-value: 1.89e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594      9 PETTFEVYVEVAYPRTGGTLS---DPEVQRQFPE-DYSDQEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQ 82
Cdd:smart00800    1 PSRLFDYFVVVGLDSDTGPLGrsyKPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSR 80


                    ....*....
gi 109825594     83 RFGFCRLSS 91
Cdd:smart00800   81 RYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 305-371 4.94e-17

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 76.17  E-value: 4.94e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594    305 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGR 371
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 31-89 1.75e-11

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 60.32  E-value: 1.75e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594    31 PEVQRQFPE-DYSDQEVLQTLTKFCFPFYVDSLtVSQVGQNFTFVLTDIDSKQRFGFCRL 89
Cdd:pfam03456    1 PEVLDRYPEdDWSDPPLPDGIPMFCFPEGLETL-SSREPTFFSFVLTDEDGSRLYGACLT 59
PHA03247 PHA03247
large tegument protein UL36; Provisional
 644-995 8.54e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.50  E-value: 8.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  644 DDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDSilnpsdkeevptPTLGSITIPRPQGRKTPELGIVPPPPIPRPAK 723
Cdd:PHA03247 2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD------------PAPGRVSRPRRARRLGRAAQASSPPQRPRRRA 2687

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  724 LQAAGAALGDVSErlqtdrdrraALSPGLLPGVVPQgPTELLQPLSPGPGAAGTSSDALLALLDPLSTAwSGSTLPSRPA 803
Cdd:PHA03247 2688 ARPTVGSLTSLAD----------PPPPPPTPEPAPH-ALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPA 2755

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  804 TPNV-ATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPfgaPPASLGPAFASGLLLSSAGFCAPHR 882
Cdd:PHA03247 2756 RPARpPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP---PAAVLAPAAALPPAASPAGPLPPPT 2832

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  883 S-QPNLSALSMPNLFGQMPMGTHTSPLQPL---GPPAVAPSRI--RTLPLARSSARAA--ETKQGLALRPGDPPLLPprp 954
Cdd:PHA03247 2833 SaQPTAPPPPPGPPPPSLPLGGSVAPGGDVrrrPPSRSPAAKPaaPARPPVRRLARPAvsRSTESFALPPDQPERPP--- 2909

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 109825594  955 pqgleptlQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAP 995
Cdd:PHA03247 2910 --------QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942
PHA03247 PHA03247
large tegument protein UL36; Provisional
 463-934 4.27e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.64  E-value: 4.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  463 PEEQLPKTAPSPLVEAKDPKLREDRRPI--TVHFGQVRPPRPHVVKRPKSNIAVEG--RRTSVPS----------PEQPQ 528
Cdd:PHA03247 2551 PPPPLPPAAPPAAPDRSVPPPRPAPRPSepAVTSRARRPDAPPQSARPRAPVDDRGdpRGPAPPSplppdthapdPPPPS 2630

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  529 PYRTLRESDSAEGDEAESPEQQVRKSTGPVPAPPDRAASIDLLEDVFSNLD---MEAALQPLGQAKSLEDLRAPKDLREq 605
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQrprRRAARPTVGSLTSLADPPPPPPTPE- 2709

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  606 pgtfdyqrldlggsERSRGVTVALKLTHPYNklwSLGQDDMAIPSKP-PAASPEKPSALLGnslalPRRPQNRDSILNPs 684
Cdd:PHA03247 2710 --------------PAPHALVSATPLPPGPA---AARQASPALPAAPaPPAVPAGPATPGG-----PARPARPPTTAGP- 2766

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  685 dkeevPTPTLGSITIPRPQGRKTPelgivppppiprpaklqAAGAALGDVSERLQTDRDRRAALSPGLLPGVVpQGPTEL 764
Cdd:PHA03247 2767 -----PAPAPPAAPAAGPPRRLTR-----------------PAVASLSESRESLPSPWDPADPPAAVLAPAAA-LPPAAS 2823

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  765 LQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLP---------SRPATPNVATPFTPQFSF----PPAGTPTPFPQPPL 831
Cdd:PHA03247 2824 PAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvrrrppSRSPAAKPAAPARPPVRRlarpAVSRSTESFALPPD 2903

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  832 NPFVPSMPAAP------PTLPLVSTPAGPFGAPPASLGPAfASGLLLSSAGFCAPHRSQPNLSALSMPNLfgQMPMGTHT 905
Cdd:PHA03247 2904 QPERPPQPQAPpppqpqPQPPPPPQPQPPPPPPPRPQPPL-APTTDPAGAGEPSGAVPQPWLGALVPGRV--AVPRFRVP 2980

                         490       500
                  ....*....|....*....|....*....
gi 109825594  906 SPLQPLGPPAVAPSRIRTLPLARSSARAA 934
Cdd:PHA03247 2981 QPAPSREAPASSTPPLTGHSLSRVSSWAS 3009
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 337-388 8.34e-08

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 49.50  E-value: 8.34e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 109825594   337 FCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGRLDLLNsgeGFSDVFEEE 388
Cdd:pfam03455    1 FDKEAFLKS-LPSDSRPFLSQFLETQMFNEFIEERLESSD---PSIDLFDEE 48
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
794-995 1.45e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.64  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  794 SGSTLPSRPATPNVATPfTPQFSFPPAGTPTPfpqpplnpfvPSMPAAPPTLPLVSTPAGPFGAPPASLGPAFASGLLLS 873
Cdd:PRK12323  369 GGGAGPATAAAAPVAQP-APAAAAPAAAAPAP----------AAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAAR 437

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  874 SAGFCAP-HRSQPNLSALSMPnlfgqmPMGTHTSPLQPLGPPAVAPSRIRTLPLARSSARAA------ETKQGLALRPGD 946
Cdd:PRK12323  438 QASARGPgGAPAPAPAPAAAP------AAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADddpppwEELPPEFASPAP 511

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 109825594  947 PPLLPPRPPQGLEPTLQPsAPQQARDPFEDLLQKTKQDVSPSPALAPAP 995
Cdd:PRK12323  512 AQPDAAPAGWVAESIPDP-ATADPDDAFETLAPAPAAAPAPRAAAATEP 559
PHA03247 PHA03247
large tegument protein UL36; Provisional
 460-867 1.05e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  460 APTPEEQLPKTAPSPLVEAKDPklREDRRPITVHFGQVRPPR------PHVVKRPKSNIAVEGRrTSVPSPEQPQPYRTL 533
Cdd:PHA03247 2734 ALPAAPAPPAVPAGPATPGGPA--RPARPPTTAGPPAPAPPAapaagpPRRLTRPAVASLSESR-ESLPSPWDPADPPAA 2810

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  534 RESDSAEGDEAESPEQQVRKSTGPVPAPPDRAASidlledvfsnldmeaalqPLGQAKSLEDLRAPkdlreqpgtfdyqr 613
Cdd:PHA03247 2811 VLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG------------------PPPPSLPLGGSVAP-------------- 2858

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  614 ldlGGSERSRGvtvalklthpynklwslgqddmaiPSKPPAASPEKPSALLGNSLALPRRPQNRDSILNPSDKEE-VPTP 692
Cdd:PHA03247 2859 ---GGDVRRRP------------------------PSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPErPPQP 2911

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  693 TLGsitiPRPQGRKTPELGIVPPPPIPRPAKLQAAGAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPTELLQPLSPGP 772
Cdd:PHA03247 2912 QAP----PPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSRE 2987

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  773 GAAGTSSDALLALLDPLSTAWSGSTLPSRPATPNVA---TPFTPQ-----------FSFPP---AGTPTPFPQPPLNPFV 835
Cdd:PHA03247 2988 APASSTPPLTGHSLSRVSSWASSLALHEETDPPPVSlkqTLWPPDdtedsdadslfDSDSErsdLEALDPLPPEPHDPFA 3067

                         410       420       430
                  ....*....|....*....|....*....|..
gi 109825594  836 PSMPAAPPTLPLVSTPAGPFGAPPASLGPAFA 867
Cdd:PHA03247 3068 HEPDPATPEAGARESPSSQFGPPPLSANAALS 3099
PHA03247 PHA03247
large tegument protein UL36; Provisional
 456-934 1.53e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  456 ENGCAPTPEEQLPKTAPSPLVEAKDPKLREDRRPiTVHFGQVRPPRPHVVKRPKSNIAVEGRRTSVPSPEQPQPYRTLRE 535
Cdd:PHA03247 2640 PHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRA-AQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSA 2718

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  536 SDSAEGDEAESPEQQVRKSTgPVPAPPDRAASIDLLEDVFSNLDMEAALQPLGQAKSLEDLRAPKDLREQPGTFDYQRLD 615
Cdd:PHA03247 2719 TPLPPGPAAARQASPALPAA-PAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  616 LGGSERSRGVTVALKLTHPYNKLWSLGQDDMAIPSKPPAASPEKPSALLGNSLAL----------PRRPQNRDSILNPSD 685
Cdd:PHA03247 2798 LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvapggdvRRRPPSRSPAAKPAA 2877

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  686 KEEVPTPTLgsitiPRPQGRKTPElgivppppiprpaklqaAGAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPTELL 765
Cdd:PHA03247 2878 PARPPVRRL-----ARPAVSRSTE-----------------SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP 2935

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  766 QPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRPATPNVATPFtpqfSFPPAGTPTPFPQPPLNPFVPSMPAAPPTL 845
Cdd:PHA03247 2936 PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQ----PAPSREAPASSTPPLTGHSLSRVSSWASSL 3011

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  846 PL-VSTPAGPFGA-----PPASLGPAFASGLLLSSAGFCAPHRSQPN----LSALSMPNLFGQMPMGTHTSPLQPLGPPA 915
Cdd:PHA03247 3012 ALhEETDPPPVSLkqtlwPPDDTEDSDADSLFDSDSERSDLEALDPLppepHDPFAHEPDPATPEAGARESPSSQFGPPP 3091

                         490
                  ....*....|....*....
gi 109825594  916 VAPSRIRTLPLARSSARAA 934
Cdd:PHA03247 3092 LSANAALSRRYVRSTGRSA 3110
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 641-997 2.13e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 2.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594   641 LGQDDMAIPSKPPAASPEKPSALLGNSLALPRRPqnrdsilnPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPR 720
Cdd:pfam03154  167 LQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPT--------PSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLH 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594   721 PAKLQAAGAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPtellQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPS 800
Cdd:pfam03154  239 PQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMP----HSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPS 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594   801 rpatPNVATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTL-PLVSTPAGPFGAPPASLGPAFASGlllsSAGFCA 879
Cdd:pfam03154  315 ----PAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIkPPPTTPIPQLPNPQSHKHPPHLSG----PSPFQM 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594   880 PHRSQPNLSALSMPNLFGQMPMGTHTSPLQ------PLGPPAVAPSRIRTLPLARSSARAAETKQGLALRPGDPPLLPPR 953
Cdd:pfam03154  387 NSNLPPPPALKPLSSLSTHHPPSAHPPPLQlmpqsqQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHP 466

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 109825594   954 PPQGLEPT-LQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAPDS 997
Cdd:pfam03154  467 FVPGGPPPiTPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVS 511
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
754-860 3.84e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 40.89  E-value: 3.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  754 PGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRPATPNVATPFTPQFSFPPAGTPTPFPQPPLNP 833
Cdd:COG3469   108 GTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATA 187

                          90       100
                  ....*....|....*....|....*..
gi 109825594  834 FVPSMPAAPPTLPLVSTPAGPFGAPPA 860
Cdd:COG3469   188 TTASGATTPSATTTATTTGPPTPGLPK 214
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 485-882 4.04e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.31  E-value: 4.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  485 EDRRPITVHFG--QVRPPRPHVVKRPKSNIAVE----GRRTSVPSPEQPQPYRTLRESD----------SAEGDEAESPE 548
Cdd:PHA03307   28 PGDAADDLLSGsqGQLVSDSAELAAVTVVAGAAacdrFEPPTGPPPGPGTEAPANESRStptwslstlaPASPAREGSPT 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  549 QQVRKSTGPVPAPPDRAASI-DLLEDVFSNLDMEAALQPLGQAKSLEDLRAPKDLREQPGTFDYQRLDLGGSERSRGVTV 627
Cdd:PHA03307  108 PPGPSSPDPPPPTPPPASPPpSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPS 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  628 ALKLTHPYNKLWSLGQDDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDSILNPS------DKEEVPTPTLGSITIPR 701
Cdd:PHA03307  188 SPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESsgcgwgPENECPLPRPAPITLPT 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  702 PQGRKTPelgivppppiprpAKLQAAGAalGDVSERlQTDRDRRAALSPG--LLPGVVPQGPTELLQPLSPGPGAAGTSS 779
Cdd:PHA03307  268 RIWEASG-------------WNGPSSRP--GPASSS-SSPRERSPSPSPSspGSGPAPSSPRASSSSSSSRESSSSSTSS 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  780 DALLALLDPLSTAWSGSTLPSRPATPNVATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPFGAPP 859
Cdd:PHA03307  332 SSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGR 411

                         410       420
                  ....*....|....*....|...
gi 109825594  860 ASLGPAFASGlllSSAGFCAPHR 882
Cdd:PHA03307  412 PRPSPLDAGA---ASGAFYARYP 431
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 647-1002 7.51e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 7.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  647 AIPSKPPAASPEKPSALLGNSLALPRRPQNRDSilNPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPRPAKLQA 726
Cdd:PRK07764  427 AAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPA--AAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPA 504

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  727 AGAALGDVSER----LQTDRDRRAALSPGLLPGVV---PQGPTELLQPLSPGPGAA------------------------ 775
Cdd:PRK07764  505 GADDAATLRERwpeiLAAVPKRSRKTWAILLPEATvlgVRGDTLVLGFSTGGLARRfaspgnaevlvtalaeelggdwqv 584

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  776 ----GTSSDALLALLDPLSTAWSGSTLPSRPATPnvATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTP 851
Cdd:PRK07764  585 eavvGPAPGAAGGEGPPAPASSGPPEEAARPAAP--AAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA 662

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  852 AGPFGAPPASLGPAFASglllssagfcaphrsqpnlsalsmpnlfGQMPMGTHTSPLQPLG--PPAVAPSRIRTLPLARS 929
Cdd:PRK07764  663 SDGGDGWPAKAGGAAPA----------------------------APPPAPAPAAPAAPAGaaPAQPAPAPAATPPAGQA 714

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 109825594  930 SARAAETKQGLALRPGDPPLLPPRPPQGLEPTLQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAPDSVEQLR 1002
Cdd:PRK07764  715 DDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAE 787
PHA03378 PHA03378
EBNA-3B; Provisional
 758-937 9.07e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.05  E-value: 9.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  758 PQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRP--ATPNVATPFTPQFSFPPAGTPTPFPQPPLNPFV 835
Cdd:PHA03378  717 PAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPgrARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTP 796

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109825594  836 PSMPAAPPTLPLVSTPagpfgAPPASLGPAFASGLLLSSAGFCAPHRSQPNLSALSMPNLFGQMP-----MGTHTSPLQP 910
Cdd:PHA03378  797 QPPPQAGPTSMQLMPR-----AAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAAAGPTPspgsgTSDKIVQAPV 871

                         170       180       190
                  ....*....|....*....|....*....|..
gi 109825594  911 LGPPAVAPSRI-----RTLPLARSSARAAETK 937
Cdd:PHA03378  872 FYPPVLQPIQVmrqlgSVRAAAASTVTQAPTE 903
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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