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Conserved domains on  [gi|74751554|sp|Q8WVL7|]
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RecName: Full=Ankyrin repeat domain-containing protein 49; AltName: Full=Fetal globin-inducing factor

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
77-218 1.01e-36

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 130.84  E-value: 1.01e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554  77 LLLWAAEKNRLTTVRRLLSEKAtHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRV 156
Cdd:COG0666  90 LLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEI 168

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74751554 157 ASFLLQHDADINAQTKGLLTPLHLAAGNRDsKDTLELLLmNRYVKPGLKNNLEETAFDIARR 218
Cdd:COG0666 169 VKLLLEAGADVNARDNDGETPLHLAAENGH-LEIVKLLL-EAGADVNAKDNDGKTALDLAAE 228
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
77-218 1.01e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 130.84  E-value: 1.01e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554  77 LLLWAAEKNRLTTVRRLLSEKAtHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRV 156
Cdd:COG0666  90 LLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEI 168

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74751554 157 ASFLLQHDADINAQTKGLLTPLHLAAGNRDsKDTLELLLmNRYVKPGLKNNLEETAFDIARR 218
Cdd:COG0666 169 VKLLLEAGADVNARDNDGETPLHLAAENGH-LEIVKLLL-EAGADVNAKDNDGKTALDLAAE 228
Ank_2 pfam12796
Ankyrin repeats (3 copies);
112-197 1.82e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 85.17  E-value: 1.82e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   112 LHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHdADINAQTKGlLTPLHLAAGNRdSKDTL 191
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSG-HLEIV 77


                  ....*.
gi 74751554   192 ELLLMN 197
Cdd:pfam12796  78 KLLLEK 83
PHA03095 PHA03095
ankyrin-like protein; Provisional
 82-215 6.83e-16

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 76.22  E-value: 6.83e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   82 AEKNRLTTVRRLLSEKAThVNTRDEDEYTPLH---RAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNT-RVA 157
Cdd:PHA03095  22 ASNVTVEEVRRLLAAGAD-VNFRGEYGKTPLHlylHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDVI 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 74751554  158 SFLLQHDADINAQTKGLLTPLHL-AAGNRDSKDTLELLLmNRYVKPGLKNNLEETAFDI 215
Cdd:PHA03095 101 KLLIKAGADVNAKDKVGRTPLHVyLSGFNINPKVIRLLL-RKGADVNALDLYGMTPLAV 158
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 60-180 3.66e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 47.31  E-value: 3.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554  60 EEWYRLQEKKMEKDPsrlLLWAAEKNRLTTVRRLLS-------------EKATHV---NTRDE----------------- 106
Cdd:cd22192   6 DELHLLQQKRISESP---LLLAAKENDVQAIKKLLKcpscdlfqrgalgETALHVaalYDNLEaavvlmeaapelvnepm 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554 107 --DEY---TPLHRAAYSGHLDIVQELIAQGADV--------------HAVTVDGWTPLHSACKWNNTRVASFLLQHDADI 167
Cdd:cd22192  83 tsDLYqgeTALHIAVVNQNLNLVRELIARGADVvspratgtffrpgpKNLIYYGEHPLSFAACVGNEEIVRLLIEHGADI 162

                       170
                ....*....|...
gi 74751554 168 NAQTKGLLTPLHL 180
Cdd:cd22192 163 RAQDSLGNTVLHI 175
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 140-169 4.74e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.19  E-value: 4.74e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 74751554    140 DGWTPLHSACKWNNTRVASFLLQHDADINA 169
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 100-199 3.91e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 38.14  E-value: 3.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   100 HVNTRDEDEY----TPLHRAAYSGHLDIVQELIAQGADVHA-------VTVDGWT-------PLHSACKWNNTRVASFLL 161
Cdd:TIGR00870 116 LANDQYTSEFtpgiTALHLAAHRQNYEIVKLLLERGASVPAracgdffVKSQGVDsfyhgesPLNAAACLGSPSIVALLS 195

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 74751554   162 QHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRY 199
Cdd:TIGR00870 196 EDPADILTADSLGNTLLHLLVMENEFKAEYEELSCQMY 233
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
77-218 1.01e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 130.84  E-value: 1.01e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554  77 LLLWAAEKNRLTTVRRLLSEKAtHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRV 156
Cdd:COG0666  90 LLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEI 168

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74751554 157 ASFLLQHDADINAQTKGLLTPLHLAAGNRDsKDTLELLLmNRYVKPGLKNNLEETAFDIARR 218
Cdd:COG0666 169 VKLLLEAGADVNARDNDGETPLHLAAENGH-LEIVKLLL-EAGADVNAKDNDGKTALDLAAE 228
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
77-218 9.06e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 115.05  E-value: 9.06e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554  77 LLLWAAEKNRLTTVRRLLSEKAtHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRV 156
Cdd:COG0666 123 PLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEI 201

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74751554 157 ASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNNLEETAFDIARR 218
Cdd:COG0666 202 VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAG 263
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
72-216 1.97e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 111.58  E-value: 1.97e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554  72 KDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKW 151
Cdd:COG0666  51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74751554 152 NNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDsKDTLELLLmNRYVKPGLKNNLEETAFDIA 216
Cdd:COG0666 131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN-LEIVKLLL-EAGADVNARDNDGETPLHLA 193
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
77-209 1.24e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 98.87  E-value: 1.24e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554  77 LLLWAAEKNRLTTVRRLLSEKAtHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRV 156
Cdd:COG0666 156 PLHLAAANGNLEIVKLLLEAGA-DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEI 234

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 74751554 157 ASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRYVKPGLKNNLE 209
Cdd:COG0666 235 VKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
Ank_2 pfam12796
Ankyrin repeats (3 copies);
112-197 1.82e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 85.17  E-value: 1.82e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   112 LHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHdADINAQTKGlLTPLHLAAGNRdSKDTL 191
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSG-HLEIV 77


                  ....*.
gi 74751554   192 ELLLMN 197
Cdd:pfam12796  78 KLLLEK 83
Ank_2 pfam12796
Ankyrin repeats (3 copies);
78-170 3.99e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 84.40  E-value: 3.99e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554    78 LLWAAEKNRLTTVRRLLSEKAtHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQgADVhAVTVDGWTPLHSACKWNNTRVA 157
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADV-NLKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|...
gi 74751554   158 SFLLQHDADINAQ 170
Cdd:pfam12796  78 KLLLEKGADINVK 90
PHA03095 PHA03095
ankyrin-like protein; Provisional
 82-215 6.83e-16

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 76.22  E-value: 6.83e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   82 AEKNRLTTVRRLLSEKAThVNTRDEDEYTPLH---RAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNT-RVA 157
Cdd:PHA03095  22 ASNVTVEEVRRLLAAGAD-VNFRGEYGKTPLHlylHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDVI 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 74751554  158 SFLLQHDADINAQTKGLLTPLHL-AAGNRDSKDTLELLLmNRYVKPGLKNNLEETAFDI 215
Cdd:PHA03095 101 KLLIKAGADVNAKDKVGRTPLHVyLSGFNINPKVIRLLL-RKGADVNALDLYGMTPLAV 158
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
56-216 1.77e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 73.83  E-value: 1.77e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554  56 DDKNEEWYRLQEKKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVH 135
Cdd:COG0666   2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554 136 AVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDsKDTLELLLmNRYVKPGLKNNLEETAFDI 215
Cdd:COG0666  82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN-LEIVKLLL-EAGADVNAQDNDGNTPLHL 159


                .
gi 74751554 216 A 216
Cdd:COG0666 160 A 160
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 85-169 3.58e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.93  E-value: 3.58e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   85 NRLTTVRRLLSeKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHD 164
Cdd:PHA03100 170 NAKNRVNYLLS-YGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNG 248


                 ....*
gi 74751554  165 ADINA 169
Cdd:PHA03100 249 PSIKT 253
Ank_4 pfam13637
Ankyrin repeats (many copies);
108-161 3.50e-14

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 64.99  E-value: 3.50e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 74751554   108 EYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLL 161
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 72-195 2.92e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 65.43  E-value: 2.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   72 KDPSRLLLWAAEKNRLTTVRRLLsEKATHVNTRDEDEYTPLHRAAYSGH-LDIVQELIAQGADVHAVTVDGWTPLHSAC- 149
Cdd:PHA03095  48 KTPLHLYLHYSSEKVKDIVRLLL-EAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHVYLs 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 74751554  150 -KWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRD-SKDTLELLL 195
Cdd:PHA03095 127 gFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNaNVELLRLLI 174
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 77-225 1.72e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 63.06  E-value: 1.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   77 LLLWAAEKNRLTTVRRLLSEKAThVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRV 156
Cdd:PHA02874 127 FLHYAIKKGDLESIKMLFEYGAD-VNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYAC 205

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74751554  157 ASFLLQHDADINAQTKGLLTPLHLAagnrdskdtlelLLMNRYVKPGLKNNLEETAFDIARRTSIYHYL 225
Cdd:PHA02874 206 IKLLIDHGNHIMNKCKNGFTPLHNA------------IIHNRSAIELLINNASINDQDIDGSTPLHHAI 262
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 72-199 6.64e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 61.22  E-value: 6.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   72 KDPSRLLLWAAEKNRLTTVRRLLsEKATHVNTRDEDEYTPLHRAAYSGH-----LDIVQELIAQGADVHAVTVDGWTPLH 146
Cdd:PHA03100  33 KKPVLPLYLAKEARNIDVVKILL-DNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLL 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 74751554  147 SA--CKWNNTRVASFLLQHDADINAQTKGLLTPLHLAA-GNRDSKDTLELLLMNRY 199
Cdd:PHA03100 112 YAisKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLeSNKIDLKILKLLIDKGV 167
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 82-216 1.25e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 60.75  E-value: 1.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   82 AEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNntRVASFLL 161
Cdd:PHA02874 164 AIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN--RSAIELL 241

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 74751554  162 QHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRyVKPGLKNNLEETAFDIA 216
Cdd:PHA02874 242 INNASINDQDIDGSTPLHHAINPPCDIDIIDILLYHK-ADISIKDNKGENPIDTA 295
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
78-178 1.34e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.97  E-value: 1.34e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554  78 LLWAAEKNRLTTVRRLLSEKAtHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVA 157
Cdd:COG0666 190 LHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIV 268

                        90       100
                ....*....|....*....|.
gi 74751554 158 SFLLQHDADINAQTKGLLTPL 178
Cdd:COG0666 269 KLLLLALLLLAAALLDLLTLL 289
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 94-197 1.81e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 60.46  E-value: 1.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   94 LSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSA-CKWNNTRVASFLLQHDADINAQTK 172
Cdd:PHA02876 361 LLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNK 440

                         90       100
                 ....*....|....*....|....*
gi 74751554  173 GLLTPLHLAAGNRDSKDTLELLLMN 197
Cdd:PHA02876 441 DLSTPLHYACKKNCKLDVIEMLLDN 465
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 88-195 3.27e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 59.51  E-value: 3.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   88 TTVRRLLSEKATHVNTRDEDE-YTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDAD 166
Cdd:PHA02878 147 AEITKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAS 226

                         90       100
                 ....*....|....*....|....*....
gi 74751554  167 INAQTKGLLTPLHLAAGNRDSKDTLELLL 195
Cdd:PHA02878 227 TDARDKCGNTPLHISVGYCKDYDILKLLL 255
Ank_4 pfam13637
Ankyrin repeats (many copies);
75-128 5.39e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.43  E-value: 5.39e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 74751554    75 SRLLLWAAEKNRLTTVRRLLsEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELI 128
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLL-EKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 68-195 5.67e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 58.74  E-value: 5.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   68 KKMEKDPSRLLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLH- 146
Cdd:PHA02878 161 NMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHi 240

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 74751554  147 SACKWNNTRVASFLLQHDADINAQTKGL-LTPLHLAAgnrDSKDTLELLL 195
Cdd:PHA02878 241 SVGYCKDYDILKLLLEHGVDVNAKSYILgLTALHSSI---KSERKLKLLL 287
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 77-198 6.19e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 58.52  E-value: 6.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   77 LLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGH--LDIVQELIAQGADVHAVT-VD------------- 140
Cdd:PHA03100 110 LLYAISKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDINAKNrVNyllsygvpinikd 189

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554  141 --GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDsKDTLELLLMNR 198
Cdd:PHA03100 190 vyGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNN-KEIFKLLLNNG 248
Ank_4 pfam13637
Ankyrin repeats (many copies);
141-195 1.03e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.97  E-value: 1.03e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 74751554   141 GWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDsKDTLELLL 195
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGN-VEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 89-197 1.31e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.58  E-value: 1.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   89 TVRRLLsEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADIN 168
Cdd:PHA02874 106 MIKTIL-DCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYAN 184

                         90       100
                 ....*....|....*....|....*....
gi 74751554  169 AQTKGLLTPLHLAAGNRDSKdTLELLLMN 197
Cdd:PHA02874 185 VKDNNGESPLHNAAEYGDYA-CIKLLIDH 212
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 79-208 1.62e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.50  E-value: 1.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRA-AYSGHLDIVQELIAQGADVHA-VTVDGWTPLHSACKwnNTRV 156
Cdd:PHA02878 205 LHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISvGYCKDYDILKLLLEHGVDVNAkSYILGLTALHSSIK--SERK 282

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 74751554  157 ASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMN----RYVKPGLKNNL 208
Cdd:PHA02878 283 LKLLLEYGADINSLNSYKLTPLSSAVKQYLCINIGRILISNicllKRIKPDIKNSE 338
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 92-163 2.28e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.13  E-value: 2.28e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74751554   92 RLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQH 163
Cdd:PTZ00322  99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 77-195 2.93e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.91  E-value: 2.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   77 LLLWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLD-IVQELIAQGADVHAVTVDGWTPLHSACKWN-NT 154
Cdd:PHA02876 242 LSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLYLMAKNGyDT 321

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 74751554  155 RVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
Cdd:PHA02876 322 ENIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITLL 362
PHA03095 PHA03095
ankyrin-like protein; Provisional
 88-186 2.94e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.49  E-value: 2.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   88 TTVRRLLSEKATHVNTRDEDEYTPLHRAAY--SGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDA 165
Cdd:PHA03095 202 ARIVRELIRAGCDPAATDMLGNTPLHSMATgsSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGA 281

                         90       100
                 ....*....|....*....|.
gi 74751554  166 DINAQTKGLLTPLHLAAGNRD 186
Cdd:PHA03095 282 DINAVSSDGNTPLSLMVRNNN 302
Ank_5 pfam13857
Ankyrin repeats (many copies);
93-148 3.41e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 48.88  E-value: 3.41e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 74751554    93 LLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSA 148
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 82-198 4.16e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.07  E-value: 4.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   82 AEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTV-DGWTPLHSACKWNNTRVASFL 160
Cdd:PHA02875  42 AMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYkDGMTPLHLATILKKLDIMKLL 121

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 74751554  161 LQHDADINAQTKGLLTPLHLAAGNRDSKDTlELLLMNR 198
Cdd:PHA02875 122 IARGADPDIPNTDKFSPLHLAVMMGDIKGI-ELLIDHK 158
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 83-198 1.49e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.20  E-value: 1.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   83 EKNRLTTV--RRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKW-----NNTR 155
Cdd:PHA03100   8 TKSRIIKVknIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIkynltDVKE 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 74751554  156 VASFLLQHDADINAQTKGLLTPLHLAAGNR-DSKDTLELLLMNR 198
Cdd:PHA03100  88 IVKLLLEYGANVNAPDNNGITPLLYAISKKsNSYSIVEYLLDNG 131
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 24-193 7.53e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 49.29  E-value: 7.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   24 FNQLELLETHGHLIPTGtqslwVGNSDEDEEQDDKNEEWYRLQEKKMEKDPSRlllwaaeknrlttVRRLLSEKATHVNT 103
Cdd:PHA02876 112 LNKHKLDEACIHILKEA-----ISGNDIHYDKINESIEYMKLIKERIQQDELL-------------IAEMLLEGGADVNA 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554  104 RDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTplhlAAG 183
Cdd:PHA02876 174 KDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDLSLLK----AIR 249

                        170
                 ....*....|
gi 74751554  184 NRDSKDTLEL 193
Cdd:PHA02876 250 NEDLETSLLL 259
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 81-186 1.03e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.83  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFL 160
Cdd:PHA02875  75 AVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELL 154

                         90       100
                 ....*....|....*....|....*.
gi 74751554  161 LQHDADINAQTKGLLTPLHLAAGNRD 186
Cdd:PHA02875 155 IDHKACLDIEDCCGCTPLIIAMAKGD 180
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 140-172 1.13e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 43.82  E-value: 1.13e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 74751554   140 DGWTPLHSAC-KWNNTRVASFLLQHDADINAQTK 172
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 78-175 1.38e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.51  E-value: 1.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   78 LLWAAEKNRLTTVRRLLsEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVhavtvdgwtplhsackwnNTRVA 157
Cdd:PHA03100 196 LHYAVYNNNPEFVKYLL-DLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSI------------------KTIIE 256

                         90
                 ....*....|....*...
gi 74751554  158 SFLLQHDADINAQTKGLL 175
Cdd:PHA03100 257 TLLYFKDKDLNTITKIKM 274
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 72-181 1.90e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.14  E-value: 1.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   72 KDPSRLLLWAAEKNRLTTVRRLLSEKAThVNTRDEDEYTPLHRAA-YSGHLDIVQELIAQGADVHAVTVDGWTPLHSACK 150
Cdd:PHA02876 306 KGETPLYLMAKNGYDTENIRTLIMLGAD-VNAADRLYITPLHQAStLDRNKDIVITLLELGANVNARDYCDKTPIHYAAV 384

                         90       100       110
                 ....*....|....*....|....*....|.
gi 74751554  151 WNNTRVASFLLQHDADINAQTKGLLTPLHLA 181
Cdd:PHA02876 385 RNNVVIINTLLDYGADIEALSQKIGTALHFA 415
PHA03095 PHA03095
ankyrin-like protein; Provisional
 101-160 1.94e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.10  E-value: 1.94e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74751554  101 VNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTR-VASFL 160
Cdd:PHA03095 250 INARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRaVRAAL 310
PHA02946 PHA02946
ankyin-like protein; Provisional
 124-186 2.54e-06

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 47.74  E-value: 2.54e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74751554  124 VQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRD 186
Cdd:PHA02946  55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDD 117
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 116-195 2.68e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.97  E-value: 2.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554  116 AYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNrDSKDTLELLL 195
Cdd:PTZ00322  90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEEN-GFREVVQLLS 168
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 140-169 3.42e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 42.63  E-value: 3.42e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 74751554   140 DGWTPLHSACKWNNTRVASFLLQHDADINA 169
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 60-180 3.66e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 47.31  E-value: 3.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554  60 EEWYRLQEKKMEKDPsrlLLWAAEKNRLTTVRRLLS-------------EKATHV---NTRDE----------------- 106
Cdd:cd22192   6 DELHLLQQKRISESP---LLLAAKENDVQAIKKLLKcpscdlfqrgalgETALHVaalYDNLEaavvlmeaapelvnepm 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554 107 --DEY---TPLHRAAYSGHLDIVQELIAQGADV--------------HAVTVDGWTPLHSACKWNNTRVASFLLQHDADI 167
Cdd:cd22192  83 tsDLYqgeTALHIAVVNQNLNLVRELIARGADVvspratgtffrpgpKNLIYYGEHPLSFAACVGNEEIVRLLIEHGADI 162

                       170
                ....*....|...
gi 74751554 168 NAQTKGLLTPLHL 180
Cdd:cd22192 163 RAQDSLGNTVLHI 175
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 140-169 4.74e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.19  E-value: 4.74e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 74751554    140 DGWTPLHSACKWNNTRVASFLLQHDADINA 169
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_5 pfam13857
Ankyrin repeats (many copies);
127-181 7.28e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.33  E-value: 7.28e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 74751554   127 LIAQG-ADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLA 181
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 107-138 9.15e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.51  E-value: 9.15e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 74751554   107 DEYTPLHRAAYS-GHLDIVQELIAQGADVHAVT 138
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
PHA03095 PHA03095
ankyrin-like protein; Provisional
 88-191 1.29e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.40  E-value: 1.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   88 TTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGH--LDIVQELIAQGADVHAVTVDGWTPLHSACKW--NNTRVASFLLQH 163
Cdd:PHA03095 132 PKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVYAVDDRFRSLLHHHLQSfkPRARIVRELIRA 211

                         90       100
                 ....*....|....*....|....*...
gi 74751554  164 DADINAQTKGLLTPLHLAAGNRDSKDTL 191
Cdd:PHA03095 212 GCDPAATDMLGNTPLHSMATGSSCKRSL 239
PHA02798 PHA02798
ankyrin-like protein; Provisional
 92-195 1.63e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 45.21  E-value: 1.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   92 RLLSEKATHVNTRDEDEYTPL-----HRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLH---SACKWNNTRVASFLLQH 163
Cdd:PHA02798  55 KLFINLGANVNGLDNEYSTPLctilsNIKDYKHMLDIVKILIENGADINKKNSDGETPLYcllSNGYINNLEILLFMIEN 134

                         90       100       110
                 ....*....|....*....|....*....|....
gi 74751554  164 DADINAQTKGLLTPL--HLAAGNRDSKDTLELLL 195
Cdd:PHA02798 135 GADTTLLDKDGFTMLqvYLQSNHHIDIEIIKLLL 168
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 107-136 2.19e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 2.19e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 74751554    107 DEYTPLHRAAYSGHLDIVQELIAQGADVHA 136
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 107-136 2.33e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 40.32  E-value: 2.33e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 74751554   107 DEYTPLHRAAYSGHLDIVQELIAQGADVHA 136
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 77-145 7.00e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 43.70  E-value: 7.00e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   77 LLLWAAEKNRLTTVRRLLsEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADV-HAVTVDGWTPL 145
Cdd:PLN03192 625 LLCTAAKRNDLTAMKELL-KQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVdKANTDDDFSPT 693
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 115-200 1.32e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 42.29  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554  115 AAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELL 194
Cdd:PHA02875   9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELL 88


                 ....*.
gi 74751554  195 LMNRYV 200
Cdd:PHA02875  89 DLGKFA 94
Ank_5 pfam13857
Ankyrin repeats (many copies);
160-216 1.71e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 1.71e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 74751554   160 LLQHD-ADINAQTKGLLTPLHLAAGNRDSkDTLELLLMNRyVKPGLKNNLEETAFDIA 216
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGAL-EIVRVLLAYG-VDLNLKDEEGLTALDLA 56
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 85-167 2.72e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.59  E-value: 2.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   85 NRLTTVRRLLsEKATHVNTRDEDEYTPLHRAAYSG-HLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNtrVASFLLQH 163
Cdd:PHA02876 420 NPYMSVKTLI-DRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIALEYHG--IVNILLHY 496


                 ....
gi 74751554  164 DADI 167
Cdd:PHA02876 497 GAEL 500
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 87-230 6.61e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 40.33  E-value: 6.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   87 LTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDAD 166
Cdd:PHA02874  14 IEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554  167 -----------------------INAQTKGLLTPLHLAAGNRDskdtleLLLMNRYVKPGLKNNLEETAFDIARRTSIYH 223
Cdd:PHA02874  94 tsilpipciekdmiktildcgidVNIKDAELKTFLHYAIKKGD------LESIKMLFEYGADVNIEDDNGCYPIHIAIKH 167


                 ....*..
gi 74751554  224 YLFEIVE 230
Cdd:PHA02874 168 NFFDIIK 174
PHA02798 PHA02798
ankyrin-like protein; Provisional
 112-215 8.40e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.20  E-value: 8.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554  112 LHRAAYSghLDIVQELIAQGADVHAVTVDGWTPL---HSACKWNNTR--VASFLLQHDADINAQTKGLLTPLHlaagnrd 186
Cdd:PHA02798  44 LQRDSPS--TDIVKLFINLGANVNGLDNEYSTPLctiLSNIKDYKHMldIVKILIENGADINKKNSDGETPLY------- 114

                         90       100
                 ....*....|....*....|....*....
gi 74751554  187 skdtleLLLMNRYVkpglkNNLEETAFDI 215
Cdd:PHA02798 115 ------CLLSNGYI-----NNLEILLFMI 132
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 111-161 8.45e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 39.86  E-value: 8.45e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 74751554  111 PLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLL 161
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMI 90
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 79-195 9.14e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 39.97  E-value: 9.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   79 LWAAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVAS 158
Cdd:PHA02875 106 LHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICK 185

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 74751554  159 FLLQHDADINAQTKGLLTPLHLAAGNRDSKDTLELLL 195
Cdd:PHA02875 186 MLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFI 222
PHA02795 PHA02795
ankyrin-like protein; Provisional
 101-148 1.04e-03

ankyrin-like protein; Provisional


Pssm-ID: 165157 [Multi-domain]  Cd Length: 437  Bit Score: 39.59  E-value: 1.04e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 74751554  101 VNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVDGWTPLHSA 148
Cdd:PHA02795 214 INQLDAGGRTLLYRAIYAGYIDLVSWLLENGANVNAVMSNGYTCLDVA 261
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 100-199 3.91e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 38.14  E-value: 3.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74751554   100 HVNTRDEDEY----TPLHRAAYSGHLDIVQELIAQGADVHA-------VTVDGWT-------PLHSACKWNNTRVASFLL 161
Cdd:TIGR00870 116 LANDQYTSEFtpgiTALHLAAHRQNYEIVKLLLERGASVPAracgdffVKSQGVDsfyhgesPLNAAACLGSPSIVALLS 195

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 74751554   162 QHDADINAQTKGLLTPLHLAAGNRDSKDTLELLLMNRY 199
Cdd:TIGR00870 196 EDPADILTADSLGNTLLHLLVMENEFKAEYEELSCQMY 233
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 92-160 8.82e-03

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 35.62  E-value: 8.82e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74751554   92 RLLSEKATHVNTRDE-DEYTPLHRAAYSGHLDIVQELIAQ-GADVHAVTVDGWTPLHSACKWNNTRVASFL 160
Cdd:PHA02736  75 KLLMEWGADINGKERvFGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYYVACERHDAKMMNIL 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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