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Conserved domains on  [gi|74732797|sp|Q9BPX7|]
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RecName: Full=UPF0415 protein C7orf25

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF5614 pfam18474
Family of unknown function (DUF5614); This is an N-terminal domain found in C7orf25 protein ...
 1-218 1.09e-157

Family of unknown function (DUF5614); This is an N-terminal domain found in C7orf25 protein UPF0415. It is distantly related to the PD-(D/E)XK nucleases.


:

Pssm-ID: 436527  Cd Length: 221  Bit Score: 443.49  E-value: 1.09e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74732797     1 MSAHSMLCERIAIAKELIKRAESLSRSRKGGIEGGAKLCSKLKAELKFLQKVEAGKVAIKESHLQSTNLTHLRAIVESAE 80
Cdd:pfam18474   1 MSVQSMLQERIAVAKELIERAEALSSSQKGGVEGGAKLCSKLRAELKFLQKVEAGKVAIKESHLQSTNLTHLKAIVESAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74732797    81 NLEEVVSVLHVFGYTDTLGEKQTLVVDVVANGGHTWVKAIGRKAEALHNIWLGRGQYGDKSIIEQAEDFLQASHQQPVQY 160
Cdd:pfam18474  81 SLEDVVSVLHVFSYEDPAGEKQTLVVDVVANGGHTWVKAIGRKAEALHNIWQGRGQYGDKSVVEQAEDFLQASRQQPVQY 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74732797   161 SNPHIIFAFYNSVSSPMAEKLKEMGISVRGDIVAVNALLDHPEE---LQPSESESDDEGPE 218
Cdd:pfam18474 161 SNPHIIFAFYNGVSSPMADRLKEMGISVRGDIVAVNSVAGGPEEeeaLSGSDEESDEEGPE 221
DUF1308 pfam07000
Protein of unknown function (DUF1308); This is a domain of unknown function found on the ...
 248-409 1.88e-91

Protein of unknown function (DUF1308); This is a domain of unknown function found on the C-terminal of C7orf25 protein UPF0415. The C-terminal domain is homologous to the known PIN-like domains. The PIN-like domain is widespread among eukaryotes, including animals, plants, and fungi, but also present in some cyanobacteria, Deinococcus, and dsDNA viruses from the Mimiviridae family. The domain retains up to four potential catalytic residues, thus, depending on the protein is predicted to be an active or inactive nuclease and in a majority of the family members, the PIN-like domain is N-terminally fused with a potentially active PD-(D/E)XK-like domain pfam18474.


:

Pssm-ID: 399767  Cd Length: 163  Bit Score: 272.99  E-value: 1.88e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74732797   248 VNLDITTLITYVSALSYGGCHFIFKEKVLTEQAEQERKEQVLPQLEAFMKDKELFACESAVKDFQSILDTLGGPGERERA 327
Cdd:pfam07000   1 LNLDVTTLLAYVSNLTNGGCNFVFKEPLLTEQAEWEREKPVKPVLDELFEGKELICCESAYDDFQSILSTLGGPKEKERA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74732797   328 TVLIKRINVVPDQPSERALR-LVASSKINSRSLTIFGTGDTLKAITMTANSGFVRAANNQGVKFSVFIHQPRALTESKEA 406
Cdd:pfam07000  81 AELLKRVEVVPDVPSDRAERsLRLSGKINPRSKRIFGTGDTLKAVTVTANEGFVRAAKMQGIEFPVFVHEPRALTEQKEA 160


                  ...
gi 74732797   407 LAT 409
Cdd:pfam07000 161 TAT 163
 
Name Accession Description Interval E-value
DUF5614 pfam18474
Family of unknown function (DUF5614); This is an N-terminal domain found in C7orf25 protein ...
 1-218 1.09e-157

Family of unknown function (DUF5614); This is an N-terminal domain found in C7orf25 protein UPF0415. It is distantly related to the PD-(D/E)XK nucleases.


Pssm-ID: 436527  Cd Length: 221  Bit Score: 443.49  E-value: 1.09e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74732797     1 MSAHSMLCERIAIAKELIKRAESLSRSRKGGIEGGAKLCSKLKAELKFLQKVEAGKVAIKESHLQSTNLTHLRAIVESAE 80
Cdd:pfam18474   1 MSVQSMLQERIAVAKELIERAEALSSSQKGGVEGGAKLCSKLRAELKFLQKVEAGKVAIKESHLQSTNLTHLKAIVESAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74732797    81 NLEEVVSVLHVFGYTDTLGEKQTLVVDVVANGGHTWVKAIGRKAEALHNIWLGRGQYGDKSIIEQAEDFLQASHQQPVQY 160
Cdd:pfam18474  81 SLEDVVSVLHVFSYEDPAGEKQTLVVDVVANGGHTWVKAIGRKAEALHNIWQGRGQYGDKSVVEQAEDFLQASRQQPVQY 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74732797   161 SNPHIIFAFYNSVSSPMAEKLKEMGISVRGDIVAVNALLDHPEE---LQPSESESDDEGPE 218
Cdd:pfam18474 161 SNPHIIFAFYNGVSSPMADRLKEMGISVRGDIVAVNSVAGGPEEeeaLSGSDEESDEEGPE 221
DUF1308 pfam07000
Protein of unknown function (DUF1308); This is a domain of unknown function found on the ...
 248-409 1.88e-91

Protein of unknown function (DUF1308); This is a domain of unknown function found on the C-terminal of C7orf25 protein UPF0415. The C-terminal domain is homologous to the known PIN-like domains. The PIN-like domain is widespread among eukaryotes, including animals, plants, and fungi, but also present in some cyanobacteria, Deinococcus, and dsDNA viruses from the Mimiviridae family. The domain retains up to four potential catalytic residues, thus, depending on the protein is predicted to be an active or inactive nuclease and in a majority of the family members, the PIN-like domain is N-terminally fused with a potentially active PD-(D/E)XK-like domain pfam18474.


Pssm-ID: 399767  Cd Length: 163  Bit Score: 272.99  E-value: 1.88e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74732797   248 VNLDITTLITYVSALSYGGCHFIFKEKVLTEQAEQERKEQVLPQLEAFMKDKELFACESAVKDFQSILDTLGGPGERERA 327
Cdd:pfam07000   1 LNLDVTTLLAYVSNLTNGGCNFVFKEPLLTEQAEWEREKPVKPVLDELFEGKELICCESAYDDFQSILSTLGGPKEKERA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74732797   328 TVLIKRINVVPDQPSERALR-LVASSKINSRSLTIFGTGDTLKAITMTANSGFVRAANNQGVKFSVFIHQPRALTESKEA 406
Cdd:pfam07000  81 AELLKRVEVVPDVPSDRAERsLRLSGKINPRSKRIFGTGDTLKAVTVTANEGFVRAAKMQGIEFPVFVHEPRALTEQKEA 160


                  ...
gi 74732797   407 LAT 409
Cdd:pfam07000 161 TAT 163
PIN_VapC_C-like cd18698
VapC-like C-terminus of DUF1308 domain in DUF1308 domain-containing proteins and related ...
 250-348 7.69e-03

VapC-like C-terminus of DUF1308 domain in DUF1308 domain-containing proteins and related proteins; This subfamily includes the C-terminus of DUF1308 domain in DUF1308 domain-containing proteins, and is an uncharacterized subfamily of the VapC (virulence-associated protein C)-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.


Pssm-ID: 350265  Cd Length: 138  Bit Score: 36.59  E-value: 7.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74732797 250 LDITTLITYVSALSYGGCHFIF---KEKVLTEQAEQERKEqvlpqLEAFMKDKELFACESAVKDFQSILDTLGGPGERER 326
Cdd:cd18698   2 LDQAVILTMCSNLSCGLSDSYYestKENINKDTVITSKNE-----IDEYLNNKQLLVCQSVYDQTKVKMEFTAGPQETIR 76

                        90       100
                ....*....|....*....|..
gi 74732797 327 ATVLIKRINVVPDQPSERALRL 348
Cdd:cd18698  77 FLELLTKITIVPDCQNDRFLKM 98
 
Name Accession Description Interval E-value
DUF5614 pfam18474
Family of unknown function (DUF5614); This is an N-terminal domain found in C7orf25 protein ...
 1-218 1.09e-157

Family of unknown function (DUF5614); This is an N-terminal domain found in C7orf25 protein UPF0415. It is distantly related to the PD-(D/E)XK nucleases.


Pssm-ID: 436527  Cd Length: 221  Bit Score: 443.49  E-value: 1.09e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74732797     1 MSAHSMLCERIAIAKELIKRAESLSRSRKGGIEGGAKLCSKLKAELKFLQKVEAGKVAIKESHLQSTNLTHLRAIVESAE 80
Cdd:pfam18474   1 MSVQSMLQERIAVAKELIERAEALSSSQKGGVEGGAKLCSKLRAELKFLQKVEAGKVAIKESHLQSTNLTHLKAIVESAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74732797    81 NLEEVVSVLHVFGYTDTLGEKQTLVVDVVANGGHTWVKAIGRKAEALHNIWLGRGQYGDKSIIEQAEDFLQASHQQPVQY 160
Cdd:pfam18474  81 SLEDVVSVLHVFSYEDPAGEKQTLVVDVVANGGHTWVKAIGRKAEALHNIWQGRGQYGDKSVVEQAEDFLQASRQQPVQY 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74732797   161 SNPHIIFAFYNSVSSPMAEKLKEMGISVRGDIVAVNALLDHPEE---LQPSESESDDEGPE 218
Cdd:pfam18474 161 SNPHIIFAFYNGVSSPMADRLKEMGISVRGDIVAVNSVAGGPEEeeaLSGSDEESDEEGPE 221
DUF1308 pfam07000
Protein of unknown function (DUF1308); This is a domain of unknown function found on the ...
 248-409 1.88e-91

Protein of unknown function (DUF1308); This is a domain of unknown function found on the C-terminal of C7orf25 protein UPF0415. The C-terminal domain is homologous to the known PIN-like domains. The PIN-like domain is widespread among eukaryotes, including animals, plants, and fungi, but also present in some cyanobacteria, Deinococcus, and dsDNA viruses from the Mimiviridae family. The domain retains up to four potential catalytic residues, thus, depending on the protein is predicted to be an active or inactive nuclease and in a majority of the family members, the PIN-like domain is N-terminally fused with a potentially active PD-(D/E)XK-like domain pfam18474.


Pssm-ID: 399767  Cd Length: 163  Bit Score: 272.99  E-value: 1.88e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74732797   248 VNLDITTLITYVSALSYGGCHFIFKEKVLTEQAEQERKEQVLPQLEAFMKDKELFACESAVKDFQSILDTLGGPGERERA 327
Cdd:pfam07000   1 LNLDVTTLLAYVSNLTNGGCNFVFKEPLLTEQAEWEREKPVKPVLDELFEGKELICCESAYDDFQSILSTLGGPKEKERA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74732797   328 TVLIKRINVVPDQPSERALR-LVASSKINSRSLTIFGTGDTLKAITMTANSGFVRAANNQGVKFSVFIHQPRALTESKEA 406
Cdd:pfam07000  81 AELLKRVEVVPDVPSDRAERsLRLSGKINPRSKRIFGTGDTLKAVTVTANEGFVRAAKMQGIEFPVFVHEPRALTEQKEA 160


                  ...
gi 74732797   407 LAT 409
Cdd:pfam07000 161 TAT 163
PIN_VapC_C-like cd18698
VapC-like C-terminus of DUF1308 domain in DUF1308 domain-containing proteins and related ...
 250-348 7.69e-03

VapC-like C-terminus of DUF1308 domain in DUF1308 domain-containing proteins and related proteins; This subfamily includes the C-terminus of DUF1308 domain in DUF1308 domain-containing proteins, and is an uncharacterized subfamily of the VapC (virulence-associated protein C)-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.


Pssm-ID: 350265  Cd Length: 138  Bit Score: 36.59  E-value: 7.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74732797 250 LDITTLITYVSALSYGGCHFIF---KEKVLTEQAEQERKEqvlpqLEAFMKDKELFACESAVKDFQSILDTLGGPGERER 326
Cdd:cd18698   2 LDQAVILTMCSNLSCGLSDSYYestKENINKDTVITSKNE-----IDEYLNNKQLLVCQSVYDQTKVKMEFTAGPQETIR 76

                        90       100
                ....*....|....*....|..
gi 74732797 327 ATVLIKRINVVPDQPSERALRL 348
Cdd:cd18698  77 FLELLTKITIVPDCQNDRFLKM 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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