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Conserved domains on  [gi|74752234|sp|Q9BQ95|]
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RecName: Full=Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; AltName: Full=Protein SITPEC; Flags: Precursor

Protein Classification

ECSIT and ECSIT_C domain-containing protein( domain architecture ID 12069163)

ECSIT and ECSIT_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ECSIT pfam06239
Evolutionarily conserved signalling intermediate in Toll pathway; Activation of NF-kappaB as a ...
 73-266 4.80e-116

Evolutionarily conserved signalling intermediate in Toll pathway; Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT plays an important role in signalling to NF-kappaB, functioning as the intermediate in the signaling pathways between TRAF-6 and MEKK-1.


:

Pssm-ID: 461857  Cd Length: 191  Bit Score: 337.02  E-value: 4.80e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752234    73 EDLFGQApgGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREYGVERDLAVYNQLLNIFPKEVFRPRNIIQRIFV 152
Cdd:pfam06239   1 EDLFSAA--GKRKKASFLMVVIFFKQRSVRRRGHVDFIYAALKKMPEFGVERDLAVYNLLLDVFPKEVFRPRNFIQRFFH 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752234   153 HYPRQQECGIAVLEQMENHGVMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLR 232
Cdd:pfam06239  79 HYPRQQECGVAVLEQMENYGVMPNKETEFLLVQIFGRKSHPMRKYRRMMYWFPKFKNSNPFPVPPVLPDDPVDLAKLGLR 158

                         170       180       190
                  ....*....|....*....|....*....|....
gi 74752234   233 HMEPDLSARVTIYQVPLPKDSTGaADPPQPHIVG 266
Cdd:pfam06239 159 RMEPDLSARVTVYQMPVPSDIDD-EDPTQPHIVG 191
ECSIT_C pfam14784
C-terminal domain of the ECSIT protein; This family represents the C-terminal domain of the ...
 269-393 2.50e-51

C-terminal domain of the ECSIT protein; This family represents the C-terminal domain of the evolutionarily conserved signaling intermediate in Toll pathway protein, an adapter protein of the Toll-like and IL-1 receptor signaling pathway, which is involved in the activation of NF-kappa-B via MAP3K1. This domain is missing in isoform 2. Fold recognition suggests that this domain may be distantly homologous to the pleckstrin homology domain


:

Pssm-ID: 464316  Cd Length: 131  Bit Score: 169.03  E-value: 2.50e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752234   269 SPDQQAALARHNPARPVFVEGPFSLWLRNKCVYYHILRAD---LLPPEEREVEETPEEWNLYYPMQLDLEYVRSGWDNY- 344
Cdd:pfam14784   1 SPEQQELLAKHPPNEPVFVEGPFPVWLRDKCVYYFVLRADpklIPPEEFEDEDDVSNERIPYFPWFLDWDKDRDEAKKEl 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 74752234   345 --EFDINEVEEGPVFAMCMAGAHDQATMAKWIQGLQETNPTLAQIPVVFRL 393
Cdd:pfam14784  81 vvKFSVHEQEDGTVFAMCATGTSSKDSLLSWIRGLQKTNPILGNIPVLFRL 131
 
Name Accession Description Interval E-value
ECSIT pfam06239
Evolutionarily conserved signalling intermediate in Toll pathway; Activation of NF-kappaB as a ...
 73-266 4.80e-116

Evolutionarily conserved signalling intermediate in Toll pathway; Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT plays an important role in signalling to NF-kappaB, functioning as the intermediate in the signaling pathways between TRAF-6 and MEKK-1.


Pssm-ID: 461857  Cd Length: 191  Bit Score: 337.02  E-value: 4.80e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752234    73 EDLFGQApgGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREYGVERDLAVYNQLLNIFPKEVFRPRNIIQRIFV 152
Cdd:pfam06239   1 EDLFSAA--GKRKKASFLMVVIFFKQRSVRRRGHVDFIYAALKKMPEFGVERDLAVYNLLLDVFPKEVFRPRNFIQRFFH 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752234   153 HYPRQQECGIAVLEQMENHGVMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLR 232
Cdd:pfam06239  79 HYPRQQECGVAVLEQMENYGVMPNKETEFLLVQIFGRKSHPMRKYRRMMYWFPKFKNSNPFPVPPVLPDDPVDLAKLGLR 158

                         170       180       190
                  ....*....|....*....|....*....|....
gi 74752234   233 HMEPDLSARVTIYQVPLPKDSTGaADPPQPHIVG 266
Cdd:pfam06239 159 RMEPDLSARVTVYQMPVPSDIDD-EDPTQPHIVG 191
ECSIT_C pfam14784
C-terminal domain of the ECSIT protein; This family represents the C-terminal domain of the ...
 269-393 2.50e-51

C-terminal domain of the ECSIT protein; This family represents the C-terminal domain of the evolutionarily conserved signaling intermediate in Toll pathway protein, an adapter protein of the Toll-like and IL-1 receptor signaling pathway, which is involved in the activation of NF-kappa-B via MAP3K1. This domain is missing in isoform 2. Fold recognition suggests that this domain may be distantly homologous to the pleckstrin homology domain


Pssm-ID: 464316  Cd Length: 131  Bit Score: 169.03  E-value: 2.50e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752234   269 SPDQQAALARHNPARPVFVEGPFSLWLRNKCVYYHILRAD---LLPPEEREVEETPEEWNLYYPMQLDLEYVRSGWDNY- 344
Cdd:pfam14784   1 SPEQQELLAKHPPNEPVFVEGPFPVWLRDKCVYYFVLRADpklIPPEEFEDEDDVSNERIPYFPWFLDWDKDRDEAKKEl 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 74752234   345 --EFDINEVEEGPVFAMCMAGAHDQATMAKWIQGLQETNPTLAQIPVVFRL 393
Cdd:pfam14784  81 vvKFSVHEQEDGTVFAMCATGTSSKDSLLSWIRGLQKTNPILGNIPVLFRL 131
 
Name Accession Description Interval E-value
ECSIT pfam06239
Evolutionarily conserved signalling intermediate in Toll pathway; Activation of NF-kappaB as a ...
 73-266 4.80e-116

Evolutionarily conserved signalling intermediate in Toll pathway; Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT plays an important role in signalling to NF-kappaB, functioning as the intermediate in the signaling pathways between TRAF-6 and MEKK-1.


Pssm-ID: 461857  Cd Length: 191  Bit Score: 337.02  E-value: 4.80e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752234    73 EDLFGQApgGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREYGVERDLAVYNQLLNIFPKEVFRPRNIIQRIFV 152
Cdd:pfam06239   1 EDLFSAA--GKRKKASFLMVVIFFKQRSVRRRGHVDFIYAALKKMPEFGVERDLAVYNLLLDVFPKEVFRPRNFIQRFFH 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752234   153 HYPRQQECGIAVLEQMENHGVMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLR 232
Cdd:pfam06239  79 HYPRQQECGVAVLEQMENYGVMPNKETEFLLVQIFGRKSHPMRKYRRMMYWFPKFKNSNPFPVPPVLPDDPVDLAKLGLR 158

                         170       180       190
                  ....*....|....*....|....*....|....
gi 74752234   233 HMEPDLSARVTIYQVPLPKDSTGaADPPQPHIVG 266
Cdd:pfam06239 159 RMEPDLSARVTVYQMPVPSDIDD-EDPTQPHIVG 191
ECSIT_C pfam14784
C-terminal domain of the ECSIT protein; This family represents the C-terminal domain of the ...
 269-393 2.50e-51

C-terminal domain of the ECSIT protein; This family represents the C-terminal domain of the evolutionarily conserved signaling intermediate in Toll pathway protein, an adapter protein of the Toll-like and IL-1 receptor signaling pathway, which is involved in the activation of NF-kappa-B via MAP3K1. This domain is missing in isoform 2. Fold recognition suggests that this domain may be distantly homologous to the pleckstrin homology domain


Pssm-ID: 464316  Cd Length: 131  Bit Score: 169.03  E-value: 2.50e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74752234   269 SPDQQAALARHNPARPVFVEGPFSLWLRNKCVYYHILRAD---LLPPEEREVEETPEEWNLYYPMQLDLEYVRSGWDNY- 344
Cdd:pfam14784   1 SPEQQELLAKHPPNEPVFVEGPFPVWLRDKCVYYFVLRADpklIPPEEFEDEDDVSNERIPYFPWFLDWDKDRDEAKKEl 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 74752234   345 --EFDINEVEEGPVFAMCMAGAHDQATMAKWIQGLQETNPTLAQIPVVFRL 393
Cdd:pfam14784  81 vvKFSVHEQEDGTVFAMCATGTSSKDSLLSWIRGLQKTNPILGNIPVLFRL 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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