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Conserved domains on  [gi|74717921|sp|Q9GZP0|]
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RecName: Full=Platelet-derived growth factor D; Short=PDGF-D; AltName: Full=Iris-expressed growth factor; AltName: Full=Spinal cord-derived growth factor B; Short=SCDGF-B; Contains: RecName: Full=Platelet-derived growth factor D, latent form; Short=PDGFD latent form; Contains: RecName: Full=Platelet-derived growth factor D, receptor-binding form; Short=PDGFD receptor-binding form; Flags: Precursor

Protein Classification

CUB domain-containing protein( domain architecture ID 10035934)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 55-168 1.16e-25

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 99.79  E-value: 1.16e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74717921  55 TIQVKGNGYVQSPRFPNSYPRNLLLTWRLHSQENTRIQLVFDnQFGLEEAENdiCRYDFVEVEDISETSTIIRGRWCGhK 134
Cdd:cd00041   4 TLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFE-DFDLESSPN--CSYDYLEIYDGPSTSSPLLGRFCG-S 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 74717921 135 EVPPRIKSRTNQIKITFKSDDYfVAKPGFKIYYS 168
Cdd:cd00041  80 TLPPPIISSGNSLTVRFRSDSS-VTGRGFKATYS 112
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 270-365 2.64e-24

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


:

Pssm-ID: 238079  Cd Length: 86  Bit Score: 95.13  E-value: 2.64e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74717921 270 YSCTPRNYSVNIREELKL-ANVVFFPRCLLVQRCGGNCgcgtvNWRSCTCNSGKTVKKYHEVLQFEPGHIKRrgraktMA 348
Cdd:cd00135   1 SSCKPRETLVEISEELPDeTNTIFKPPCVEVKRCGGCC-----NDESLECVPTETSNVTMQVLKISPKRKPR------SK 69

                        90
                ....*....|....*..
gi 74717921 349 LVDIQLDHHERCDCICS 365
Cdd:cd00135  70 LVEISFEEHTECECRPR 86
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 55-168 1.16e-25

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 99.79  E-value: 1.16e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74717921  55 TIQVKGNGYVQSPRFPNSYPRNLLLTWRLHSQENTRIQLVFDnQFGLEEAENdiCRYDFVEVEDISETSTIIRGRWCGhK 134
Cdd:cd00041   4 TLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFE-DFDLESSPN--CSYDYLEIYDGPSTSSPLLGRFCG-S 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 74717921 135 EVPPRIKSRTNQIKITFKSDDYfVAKPGFKIYYS 168
Cdd:cd00041  80 TLPPPIISSGNSLTVRFRSDSS-VTGRGFKATYS 112
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 270-365 2.64e-24

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 95.13  E-value: 2.64e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74717921 270 YSCTPRNYSVNIREELKL-ANVVFFPRCLLVQRCGGNCgcgtvNWRSCTCNSGKTVKKYHEVLQFEPGHIKRrgraktMA 348
Cdd:cd00135   1 SSCKPRETLVEISEELPDeTNTIFKPPCVEVKRCGGCC-----NDESLECVPTETSNVTMQVLKISPKRKPR------SK 69

                        90
                ....*....|....*..
gi 74717921 349 LVDIQLDHHERCDCICS 365
Cdd:cd00135  70 LVEISFEEHTECECRPR 86
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 62-167 2.46e-23

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 92.84  E-value: 2.46e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74717921     62 GYVQSPRFPNSYPRNLLLTWRLHSQENTRIQLVFDnQFGLEEAENdiCRYDFVEVEDISETSTIIRGRWCGHKEVPPRIK 141
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFT-DFDLESSDN--CEYDYVEIYDGPSASSPLLGRFCGSEAPPPVIS 77

                           90       100
                   ....*....|....*....|....*.
gi 74717921    142 SRTNQIKITFKSDDYFVAKpGFKIYY 167
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKR-GFSARY 102
CUB pfam00431
CUB domain;
61-167 1.20e-22

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 91.20  E-value: 1.20e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74717921    61 NGYVQSPRFPNSYPRNLLLTWRLHSQENTRIQLVFDNqFGLEeaENDICRYDFVEVEDISETSTIIRGRWCGhKEVPPRI 140
Cdd:pfam00431   9 SGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELE--DHDECGYDYVEIRDGPSASSPLLGRFCG-SGIPEDI 84

                          90       100
                  ....*....|....*....|....*..
gi 74717921   141 KSRTNQIKITFKSDDYFVAKpGFKIYY 167
Cdd:pfam00431  85 VSSSNQMTIKFVSDASVQKR-GFKATY 110
PDGF pfam00341
PDGF/VEGF domain;
272-362 1.11e-19

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 82.33  E-value: 1.11e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74717921   272 CTPRNYSVNIREELKLANVVFF-PRCLLVQRCGGNCgcgtvNWRSCTCNSGKTVKKYHEVLQfepghIKRRGRAKTMALV 350
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFkPSCVEVQRCSGCC-----NDEGLECVPTETHNVTMQVLK-----IEYAPRRPSPELV 70

                          90
                  ....*....|..
gi 74717921   351 DIQLDHHERCDC 362
Cdd:pfam00341  71 EVSFEEHVQCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 272-363 4.46e-05

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 41.64  E-value: 4.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74717921    272 CTPRNYSVNIREEL-KLANVVFFPRCLLVQRCGGNCgcgtvNWRSCTCNSGKTVKKYHEVLQFEPGhikrrgraKTMALV 350
Cdd:smart00141   3 CKPRETVVEVSREYpDETNFLFKPPCVTVKRCGGCC-----NDEGLECVPTETSNVTMQLLEISRP--------LSQHLV 69

                           90
                   ....*....|...
gi 74717921    351 DIQLDHHERCDCI 363
Cdd:smart00141  70 EVSFEEHTKCECR 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 271-369 1.00e-03

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 39.22  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74717921  271 SCTPRNYSVNIREEL-KLANVVFFPRCLLVQRCGGNCgcgtvNWRSCTCNSGKTVKKYHEVLQFEpghiKRRGRAKTMAL 349
Cdd:PHA02661  47 SCQPRDTVVQLSDEYpGNTNDRYNPRCVTVRRCGGCC-----NDESQICTPTETSNVTVTVMLTS----VSGSTGATSNF 117

                         90       100
                 ....*....|....*....|
gi 74717921  350 VDIQLDHHERCDCICSSRPP 369
Cdd:PHA02661 118 QTISVEEHTKCKCEFKTTPP 137
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 55-168 1.16e-25

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 99.79  E-value: 1.16e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74717921  55 TIQVKGNGYVQSPRFPNSYPRNLLLTWRLHSQENTRIQLVFDnQFGLEEAENdiCRYDFVEVEDISETSTIIRGRWCGhK 134
Cdd:cd00041   4 TLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFE-DFDLESSPN--CSYDYLEIYDGPSTSSPLLGRFCG-S 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 74717921 135 EVPPRIKSRTNQIKITFKSDDYfVAKPGFKIYYS 168
Cdd:cd00041  80 TLPPPIISSGNSLTVRFRSDSS-VTGRGFKATYS 112
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 270-365 2.64e-24

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 95.13  E-value: 2.64e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74717921 270 YSCTPRNYSVNIREELKL-ANVVFFPRCLLVQRCGGNCgcgtvNWRSCTCNSGKTVKKYHEVLQFEPGHIKRrgraktMA 348
Cdd:cd00135   1 SSCKPRETLVEISEELPDeTNTIFKPPCVEVKRCGGCC-----NDESLECVPTETSNVTMQVLKISPKRKPR------SK 69

                        90
                ....*....|....*..
gi 74717921 349 LVDIQLDHHERCDCICS 365
Cdd:cd00135  70 LVEISFEEHTECECRPR 86
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 62-167 2.46e-23

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 92.84  E-value: 2.46e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74717921     62 GYVQSPRFPNSYPRNLLLTWRLHSQENTRIQLVFDnQFGLEEAENdiCRYDFVEVEDISETSTIIRGRWCGHKEVPPRIK 141
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFT-DFDLESSDN--CEYDYVEIYDGPSASSPLLGRFCGSEAPPPVIS 77

                           90       100
                   ....*....|....*....|....*.
gi 74717921    142 SRTNQIKITFKSDDYFVAKpGFKIYY 167
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKR-GFSARY 102
CUB pfam00431
CUB domain;
61-167 1.20e-22

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 91.20  E-value: 1.20e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74717921    61 NGYVQSPRFPNSYPRNLLLTWRLHSQENTRIQLVFDNqFGLEeaENDICRYDFVEVEDISETSTIIRGRWCGhKEVPPRI 140
Cdd:pfam00431   9 SGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELE--DHDECGYDYVEIRDGPSASSPLLGRFCG-SGIPEDI 84

                          90       100
                  ....*....|....*....|....*..
gi 74717921   141 KSRTNQIKITFKSDDYFVAKpGFKIYY 167
Cdd:pfam00431  85 VSSSNQMTIKFVSDASVQKR-GFKATY 110
PDGF pfam00341
PDGF/VEGF domain;
272-362 1.11e-19

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 82.33  E-value: 1.11e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74717921   272 CTPRNYSVNIREELKLANVVFF-PRCLLVQRCGGNCgcgtvNWRSCTCNSGKTVKKYHEVLQfepghIKRRGRAKTMALV 350
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFkPSCVEVQRCSGCC-----NDEGLECVPTETHNVTMQVLK-----IEYAPRRPSPELV 70

                          90
                  ....*....|..
gi 74717921   351 DIQLDHHERCDC 362
Cdd:pfam00341  71 EVSFEEHVQCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 272-363 4.46e-05

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 41.64  E-value: 4.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74717921    272 CTPRNYSVNIREEL-KLANVVFFPRCLLVQRCGGNCgcgtvNWRSCTCNSGKTVKKYHEVLQFEPGhikrrgraKTMALV 350
Cdd:smart00141   3 CKPRETVVEVSREYpDETNFLFKPPCVTVKRCGGCC-----NDEGLECVPTETSNVTMQLLEISRP--------LSQHLV 69

                           90
                   ....*....|...
gi 74717921    351 DIQLDHHERCDCI 363
Cdd:smart00141  70 EVSFEEHTKCECR 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 271-369 1.00e-03

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 39.22  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74717921  271 SCTPRNYSVNIREEL-KLANVVFFPRCLLVQRCGGNCgcgtvNWRSCTCNSGKTVKKYHEVLQFEpghiKRRGRAKTMAL 349
Cdd:PHA02661  47 SCQPRDTVVQLSDEYpGNTNDRYNPRCVTVRRCGGCC-----NDESQICTPTETSNVTVTVMLTS----VSGSTGATSNF 117

                         90       100
                 ....*....|....*....|
gi 74717921  350 VDIQLDHHERCDCICSSRPP 369
Cdd:PHA02661 118 QTISVEEHTKCKCEFKTTPP 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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