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Conserved domains on  [gi|37082580|sp|Q9W6T7|]
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RecName: Full=Presenilin-1; Short=PS-1; Short=Zf-PS1

Protein Classification

presenilin( domain architecture ID 10471201)

presenilin is the catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Presenilin pfam01080
Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It ...
64-446 6.73e-180

Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It has been found that presenilin-1 binds to beta-catenin in-vivo. This family also contains SPE proteins from C.elegans.


:

Pssm-ID: 460052  Cd Length: 394  Bit Score: 508.30  E-value: 6.73e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580    64 KYGAKHVIMLFIPVTLCMVVVVATIKSVSFYT--QKDGQQLIYTPFREDTETVGQRALHSMLNAIIMISVIVVMTLVLVV 141
Cdd:pfam01080   1 KYGAKQVIKLFVPVSLCMLLVVATIRSISFYSsqVNDEASLVYTPFHEESDSTGTKLLNSLLNALIFIGVIVVMTFLLVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580   142 LYKYRCYKVIQAWLFFSNLLLLFFFSLIYLGEVFKTYNVAMDYFTLALIIWNFGVVGMICIHWKGPLRLQQAYLIMISAL 221
Cdd:pfam01080  81 LYKYRCYKVIHGWLILSSLLLLFLFSGLYLGELLSAYNIPMDYITFAFILWNFGVVGMIAIFWKGPLLLQQAYLISISAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580   222 MALVFIKYLPEWTAWLILAAISVYDLLAVLCPKGPLRILVETAQERNEAIFPALIYSSTMVWLF-----NMADSAETRNN 296
Cdd:pfam01080 161 MALVFIKYLPEWTTWVLLVVISIWDLFAVLCPKGPLRLLVETAQERNEPIFPALIYSATMVWLYagsqvAMSDEGTSART 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580   297 SSHPVPQQENQV-------VAMAPTAQAEDDGGFTPAWVDHQQHQlgpmQSTEESRRQIQEMPSARPPP---PADDDEER 366
Cdd:pfam01080 241 VKQTISNYSKNEasesefsQSSRSSRTANPDSGLTWPTSPPELSS----ERSEEAQSPLSSSTEESSEPeenRNKLNDSR 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580   367 GVKLGLGDFIFYSMLVGKASatASGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDNLVRPFM 446
Cdd:pfam01080 317 GVKLGLGDFIFYSVLVGKAA--MYGDWNTVIACFVAILIGLCLTLLLLAIFKKALPALPISIAFGLIFYFSTRFLVEPFV 394
 
Name Accession Description Interval E-value
Presenilin pfam01080
Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It ...
64-446 6.73e-180

Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It has been found that presenilin-1 binds to beta-catenin in-vivo. This family also contains SPE proteins from C.elegans.


Pssm-ID: 460052  Cd Length: 394  Bit Score: 508.30  E-value: 6.73e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580    64 KYGAKHVIMLFIPVTLCMVVVVATIKSVSFYT--QKDGQQLIYTPFREDTETVGQRALHSMLNAIIMISVIVVMTLVLVV 141
Cdd:pfam01080   1 KYGAKQVIKLFVPVSLCMLLVVATIRSISFYSsqVNDEASLVYTPFHEESDSTGTKLLNSLLNALIFIGVIVVMTFLLVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580   142 LYKYRCYKVIQAWLFFSNLLLLFFFSLIYLGEVFKTYNVAMDYFTLALIIWNFGVVGMICIHWKGPLRLQQAYLIMISAL 221
Cdd:pfam01080  81 LYKYRCYKVIHGWLILSSLLLLFLFSGLYLGELLSAYNIPMDYITFAFILWNFGVVGMIAIFWKGPLLLQQAYLISISAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580   222 MALVFIKYLPEWTAWLILAAISVYDLLAVLCPKGPLRILVETAQERNEAIFPALIYSSTMVWLF-----NMADSAETRNN 296
Cdd:pfam01080 161 MALVFIKYLPEWTTWVLLVVISIWDLFAVLCPKGPLRLLVETAQERNEPIFPALIYSATMVWLYagsqvAMSDEGTSART 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580   297 SSHPVPQQENQV-------VAMAPTAQAEDDGGFTPAWVDHQQHQlgpmQSTEESRRQIQEMPSARPPP---PADDDEER 366
Cdd:pfam01080 241 VKQTISNYSKNEasesefsQSSRSSRTANPDSGLTWPTSPPELSS----ERSEEAQSPLSSSTEESSEPeenRNKLNDSR 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580   367 GVKLGLGDFIFYSMLVGKASatASGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDNLVRPFM 446
Cdd:pfam01080 317 GVKLGLGDFIFYSVLVGKAA--MYGDWNTVIACFVAILIGLCLTLLLLAIFKKALPALPISIAFGLIFYFSTRFLVEPFV 394
PSN smart00730
Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic ...
119-442 2.42e-60

Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic membrane proteins, whose genes are mutated in some individuals with Alzheimer's disease. Distant homologues, present in eukaryotes and archaea, also contain conserved aspartic acid residues which are predicted to contribute to catalysis. At least one member of this family has been shown to possess signal peptide peptidase activity.


Pssm-ID: 214793  Cd Length: 249  Bit Score: 197.47  E-value: 2.42e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580    119 LHSMLNAIIMISVIVVMTLVLVVLYKYRCYKVIQAWLFFSNLLLLFFFSLIYLGEVFKtynvaMDYFTLALIIWNFGVVG 198
Cdd:smart00730   1 EYSLLNSLVAIVFPIVATFVLVLLYKFFKYLVIVLVIYFSSLGVLFLYSLLYPLEVFR-----VDYPTLLILLLNFAVVG 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580    199 MICIHWKgpLRLQQAYLIMISALMALVFIKYLP-EWTAWLILAAISVYDLLAVLCPKGPLRILVETAQERNEAI--FPAL 275
Cdd:smart00730  76 FWCIHRK--GAWIQQDLIGISLCMAILFILRLPsEWTAWILLGALFIYDIFAVFGTPGPLRVMVEVATGRDEPIkvFPAL 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580    276 IYSSTMVWlfnmadsaetrnnsshpvpqqenqvvamaptaqaeddggftpawvdhqqhqlgpmqsteesrrqiqempsar 355
Cdd:smart00730 154 LYVPRLVV------------------------------------------------------------------------ 161
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580    356 ppPPADDDEERGVKLGLGDFIFYSMLVGKASATAS---GDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGL 432
Cdd:smart00730 162 --SFEDDEEERFSMLGLGDIVFPGILVASAARFDVsvrSDSNYFLACFVAYGIGLILTLVLLALFKKAQPALPYLVPFTL 239
                          330
                   ....*....|
gi 37082580    433 VFYFATDNLV 442
Cdd:smart00730 240 VFYLLTALLR 249
 
Name Accession Description Interval E-value
Presenilin pfam01080
Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It ...
64-446 6.73e-180

Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It has been found that presenilin-1 binds to beta-catenin in-vivo. This family also contains SPE proteins from C.elegans.


Pssm-ID: 460052  Cd Length: 394  Bit Score: 508.30  E-value: 6.73e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580    64 KYGAKHVIMLFIPVTLCMVVVVATIKSVSFYT--QKDGQQLIYTPFREDTETVGQRALHSMLNAIIMISVIVVMTLVLVV 141
Cdd:pfam01080   1 KYGAKQVIKLFVPVSLCMLLVVATIRSISFYSsqVNDEASLVYTPFHEESDSTGTKLLNSLLNALIFIGVIVVMTFLLVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580   142 LYKYRCYKVIQAWLFFSNLLLLFFFSLIYLGEVFKTYNVAMDYFTLALIIWNFGVVGMICIHWKGPLRLQQAYLIMISAL 221
Cdd:pfam01080  81 LYKYRCYKVIHGWLILSSLLLLFLFSGLYLGELLSAYNIPMDYITFAFILWNFGVVGMIAIFWKGPLLLQQAYLISISAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580   222 MALVFIKYLPEWTAWLILAAISVYDLLAVLCPKGPLRILVETAQERNEAIFPALIYSSTMVWLF-----NMADSAETRNN 296
Cdd:pfam01080 161 MALVFIKYLPEWTTWVLLVVISIWDLFAVLCPKGPLRLLVETAQERNEPIFPALIYSATMVWLYagsqvAMSDEGTSART 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580   297 SSHPVPQQENQV-------VAMAPTAQAEDDGGFTPAWVDHQQHQlgpmQSTEESRRQIQEMPSARPPP---PADDDEER 366
Cdd:pfam01080 241 VKQTISNYSKNEasesefsQSSRSSRTANPDSGLTWPTSPPELSS----ERSEEAQSPLSSSTEESSEPeenRNKLNDSR 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580   367 GVKLGLGDFIFYSMLVGKASatASGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDNLVRPFM 446
Cdd:pfam01080 317 GVKLGLGDFIFYSVLVGKAA--MYGDWNTVIACFVAILIGLCLTLLLLAIFKKALPALPISIAFGLIFYFSTRFLVEPFV 394
PSN smart00730
Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic ...
119-442 2.42e-60

Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic membrane proteins, whose genes are mutated in some individuals with Alzheimer's disease. Distant homologues, present in eukaryotes and archaea, also contain conserved aspartic acid residues which are predicted to contribute to catalysis. At least one member of this family has been shown to possess signal peptide peptidase activity.


Pssm-ID: 214793  Cd Length: 249  Bit Score: 197.47  E-value: 2.42e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580    119 LHSMLNAIIMISVIVVMTLVLVVLYKYRCYKVIQAWLFFSNLLLLFFFSLIYLGEVFKtynvaMDYFTLALIIWNFGVVG 198
Cdd:smart00730   1 EYSLLNSLVAIVFPIVATFVLVLLYKFFKYLVIVLVIYFSSLGVLFLYSLLYPLEVFR-----VDYPTLLILLLNFAVVG 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580    199 MICIHWKgpLRLQQAYLIMISALMALVFIKYLP-EWTAWLILAAISVYDLLAVLCPKGPLRILVETAQERNEAI--FPAL 275
Cdd:smart00730  76 FWCIHRK--GAWIQQDLIGISLCMAILFILRLPsEWTAWILLGALFIYDIFAVFGTPGPLRVMVEVATGRDEPIkvFPAL 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580    276 IYSSTMVWlfnmadsaetrnnsshpvpqqenqvvamaptaqaeddggftpawvdhqqhqlgpmqsteesrrqiqempsar 355
Cdd:smart00730 154 LYVPRLVV------------------------------------------------------------------------ 161
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37082580    356 ppPPADDDEERGVKLGLGDFIFYSMLVGKASATAS---GDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGL 432
Cdd:smart00730 162 --SFEDDEEERFSMLGLGDIVFPGILVASAARFDVsvrSDSNYFLACFVAYGIGLILTLVLLALFKKAQPALPYLVPFTL 239
                          330
                   ....*....|
gi 37082580    433 VFYFATDNLV 442
Cdd:smart00730 240 VFYLLTALLR 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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