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Conserved domains on  [gi|160410012|sp|Q9Y2M0|]
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RecName: Full=Fanconi-associated nuclease 1; AltName: Full=FANCD2/FANCI-associated nuclease 1; Short=hFAN1; AltName: Full=Myotubularin-related protein 15

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FAN1-like cd22326
repair nuclease FAN1; This model characterizes a set of nucleases that resemble ...
373-1017 0e+00

repair nuclease FAN1; This model characterizes a set of nucleases that resemble Holliday-junction resolving enzymes. They belong to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.


:

Pssm-ID: 411730 [Multi-domain]  Cd Length: 652  Bit Score: 800.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  373 PYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQLSATGQKLYVRLFQRKL-SWIKMTKLEYEE---IALDLTPVIE 448
Cdd:cd22326     1 PYYLRSFLEILKTVLENEDHRSLFDEEELGLLDKFLSLSDPAQKLFVRLFQRKLkSWLRLSKLKYPEialIALDLSPLLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  449 ELTNAGFLQTESELQELSEVLELLSAPELKSLAKTFHLVNPNGQKQQL--VDAFLKLAKQRSVCTwgknkpgIGAVILKR 526
Cdd:cd22326    81 ELVEAGFLESDTDLLDLSELLELLSAPELKELAKEFKLKKKKKKKKRLllLEALLKLAKQRSSGL-------LGAALLKR 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  527 AKALAG--QSVRIC---KGPRAVFSRILLLFSLTDSMEDEDAACGGQGQLSTVLLVNLGRMEFPSYTINRKTHIFQDRDD 601
Cdd:cd22326   154 AKALAGleQSLRLCllsRLPRAVLSRVLLLFSLLDLLVYERSTLGGEDLLTTLLLVRLGKRKYPSYTVSRTTPIFASRDE 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  602 LIRYAAATHMLSDISSAMANGNWEEAKELAQCAKRDWNRLKNHP-SLRCHEDLPLFLRCFTVGWIYTRILSRFVEILQRL 680
Cdd:cd22326   234 LLRYEEALELEEELDELLENKKWEDAKELLELAKRVWERLKEEVlALRSEEDLPEFLRRFTAGWVYTRILSKGVEALEKL 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  681 HMYEEAVRELESLLSQRIYCPDSRGRWWDRLALNLHQHLKR--LEPTIKCITEGLADPEVRTGHRLSLYQRAVRLRESPS 758
Cdd:cd22326   314 KEYEEAVELLEALLAQRRWRRGKRGRWYDRLALILMTHLKKdsLEEALEVLIEGLADPDVRLGHRLALLRRALRLEKSLR 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  759 --CKKFKHLFQQLPEMA--VQDVKHVTITGRLCPQR--GMCKSVFVMEAGeaaDPTTVLCSVEELALAHYRRSGFDQGIH 832
Cdd:cd22326   394 giPKKLKHLFEELLLDAalLKDIKEVTIKGRLLPSEeaGGKKSVFVGEDK---DRDGEEVSVEELALQHYEDEGFWKGFH 470
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  833 GEGSTFSTLYGLLLWDIIFMDgIPDVFRNACQAFPLDLCTDSFFTSRRPALEARLQLIHDAPEESLRAWVAATWHEQEGR 912
Cdd:cd22326   471 SEGSILTTLFGLLFWDIIFAP-VPGAFETPYQTAPLDLATDSFYYARKDLIEARLEEIEEGSAEELEELVEDTWREREGE 549
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  913 VASLVSWDRFtSLQQAQDLVSCLGGPVLSGVCRHLAADFRHCRGGLPDLVVWNSQSRHFKLVEVKGPNDRLSHKQMIWLA 992
Cdd:cd22326   550 WCVGVNWDLF-SLEDLLEIVECLGGKALAVICRLLAEDYRHCSGGFPDLLLWNPETKKCKFVEVKGPGDRLSEKQKLWLD 628
                         650       660
                  ....*....|....*....|....*
gi 160410012  993 ELQKLGAEVEVCHVVAvGAKSQSLS 1017
Cdd:cd22326   629 VLLRAGVDVEVCHVVE-EAKSKKLK 652
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
41-62 3.32e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


:

Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 41.44  E-value: 3.32e-05
                            10        20
                    ....*....|....*....|..
gi 160410012     41 KLACPVCSKMVPRYDLNRHLDE 62
Cdd:smart00734    1 LVQCPVCFREVPENLINSHLDS 22
 
Name Accession Description Interval E-value
FAN1-like cd22326
repair nuclease FAN1; This model characterizes a set of nucleases that resemble ...
373-1017 0e+00

repair nuclease FAN1; This model characterizes a set of nucleases that resemble Holliday-junction resolving enzymes. They belong to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.


Pssm-ID: 411730 [Multi-domain]  Cd Length: 652  Bit Score: 800.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  373 PYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQLSATGQKLYVRLFQRKL-SWIKMTKLEYEE---IALDLTPVIE 448
Cdd:cd22326     1 PYYLRSFLEILKTVLENEDHRSLFDEEELGLLDKFLSLSDPAQKLFVRLFQRKLkSWLRLSKLKYPEialIALDLSPLLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  449 ELTNAGFLQTESELQELSEVLELLSAPELKSLAKTFHLVNPNGQKQQL--VDAFLKLAKQRSVCTwgknkpgIGAVILKR 526
Cdd:cd22326    81 ELVEAGFLESDTDLLDLSELLELLSAPELKELAKEFKLKKKKKKKKRLllLEALLKLAKQRSSGL-------LGAALLKR 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  527 AKALAG--QSVRIC---KGPRAVFSRILLLFSLTDSMEDEDAACGGQGQLSTVLLVNLGRMEFPSYTINRKTHIFQDRDD 601
Cdd:cd22326   154 AKALAGleQSLRLCllsRLPRAVLSRVLLLFSLLDLLVYERSTLGGEDLLTTLLLVRLGKRKYPSYTVSRTTPIFASRDE 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  602 LIRYAAATHMLSDISSAMANGNWEEAKELAQCAKRDWNRLKNHP-SLRCHEDLPLFLRCFTVGWIYTRILSRFVEILQRL 680
Cdd:cd22326   234 LLRYEEALELEEELDELLENKKWEDAKELLELAKRVWERLKEEVlALRSEEDLPEFLRRFTAGWVYTRILSKGVEALEKL 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  681 HMYEEAVRELESLLSQRIYCPDSRGRWWDRLALNLHQHLKR--LEPTIKCITEGLADPEVRTGHRLSLYQRAVRLRESPS 758
Cdd:cd22326   314 KEYEEAVELLEALLAQRRWRRGKRGRWYDRLALILMTHLKKdsLEEALEVLIEGLADPDVRLGHRLALLRRALRLEKSLR 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  759 --CKKFKHLFQQLPEMA--VQDVKHVTITGRLCPQR--GMCKSVFVMEAGeaaDPTTVLCSVEELALAHYRRSGFDQGIH 832
Cdd:cd22326   394 giPKKLKHLFEELLLDAalLKDIKEVTIKGRLLPSEeaGGKKSVFVGEDK---DRDGEEVSVEELALQHYEDEGFWKGFH 470
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  833 GEGSTFSTLYGLLLWDIIFMDgIPDVFRNACQAFPLDLCTDSFFTSRRPALEARLQLIHDAPEESLRAWVAATWHEQEGR 912
Cdd:cd22326   471 SEGSILTTLFGLLFWDIIFAP-VPGAFETPYQTAPLDLATDSFYYARKDLIEARLEEIEEGSAEELEELVEDTWREREGE 549
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  913 VASLVSWDRFtSLQQAQDLVSCLGGPVLSGVCRHLAADFRHCRGGLPDLVVWNSQSRHFKLVEVKGPNDRLSHKQMIWLA 992
Cdd:cd22326   550 WCVGVNWDLF-SLEDLLEIVECLGGKALAVICRLLAEDYRHCSGGFPDLLLWNPETKKCKFVEVKGPGDRLSEKQKLWLD 628
                         650       660
                  ....*....|....*....|....*
gi 160410012  993 ELQKLGAEVEVCHVVAvGAKSQSLS 1017
Cdd:cd22326   629 VLLRAGVDVEVCHVVE-EAKSKKLK 652
VRR_NUC pfam08774
VRR-NUC domain;
893-1008 4.02e-38

VRR-NUC domain;


Pssm-ID: 430209  Cd Length: 115  Bit Score: 137.97  E-value: 4.02e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012   893 APEESLRAWVAATWHEQEGRVASLVSWDRFTSLQQaqDLVSCLGGPVLSGVCRHLAADFRHCRGGLPDLVVWNSQSRH-F 971
Cdd:pfam08774    1 NKEGSIEVAIAETLELKRGLPLPGVNWGELSEELE--QALQCLPGEALAAWFRRLAQDYRGLGSGRPDLVLWNPEQKRvF 78
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 160410012   972 KLVEVKGPNDRLSHKQMIWLAELQKLGAEVEVCHVVA 1008
Cdd:pfam08774   79 LLVEVKGPGDRLSDNQRAWIDELRRSGVRVEVCRVAA 115
VRR_NUC smart00990
This model contains proteins with the VRR-NUC domain; It is associated with members of the PD- ...
893-1008 5.56e-33

This model contains proteins with the VRR-NUC domain; It is associated with members of the PD-(D/E)XK nuclease superfamily, which include the type III restriction modification enzymes, for example StyLTI.


Pssm-ID: 214959  Cd Length: 108  Bit Score: 123.00  E-value: 5.56e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012    893 APEESLRAWVAATWHEQegrvASLVSWdrftSLQQAQDLVSCLGGPVLSGVCRHLAADFRHCRGGLPDLVVWNSQSRHFK 972
Cdd:smart00990    1 MTEGKALVLIDDRFDIE----NPLVRW----PLEGLSLLLDCLPVKALKGIAGRFASDYPGLRGGVPDLILFLPQDGRYR 72
                            90       100       110
                    ....*....|....*....|....*....|....*.
gi 160410012    973 LVEVKGPNDRLSHKQMIWLAELQKLGAEVEVCHVVA 1008
Cdd:smart00990   73 FVEVKGPGDRLSPLQKRWIDRLAGLGFRVEVCDVVE 108
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
41-62 3.32e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 41.44  E-value: 3.32e-05
                            10        20
                    ....*....|....*....|..
gi 160410012     41 KLACPVCSKMVPRYDLNRHLDE 62
Cdd:smart00734    1 LVQCPVCFREVPENLINSHLDS 22
 
Name Accession Description Interval E-value
FAN1-like cd22326
repair nuclease FAN1; This model characterizes a set of nucleases that resemble ...
373-1017 0e+00

repair nuclease FAN1; This model characterizes a set of nucleases that resemble Holliday-junction resolving enzymes. They belong to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.


Pssm-ID: 411730 [Multi-domain]  Cd Length: 652  Bit Score: 800.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  373 PYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQLSATGQKLYVRLFQRKL-SWIKMTKLEYEE---IALDLTPVIE 448
Cdd:cd22326     1 PYYLRSFLEILKTVLENEDHRSLFDEEELGLLDKFLSLSDPAQKLFVRLFQRKLkSWLRLSKLKYPEialIALDLSPLLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  449 ELTNAGFLQTESELQELSEVLELLSAPELKSLAKTFHLVNPNGQKQQL--VDAFLKLAKQRSVCTwgknkpgIGAVILKR 526
Cdd:cd22326    81 ELVEAGFLESDTDLLDLSELLELLSAPELKELAKEFKLKKKKKKKKRLllLEALLKLAKQRSSGL-------LGAALLKR 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  527 AKALAG--QSVRIC---KGPRAVFSRILLLFSLTDSMEDEDAACGGQGQLSTVLLVNLGRMEFPSYTINRKTHIFQDRDD 601
Cdd:cd22326   154 AKALAGleQSLRLCllsRLPRAVLSRVLLLFSLLDLLVYERSTLGGEDLLTTLLLVRLGKRKYPSYTVSRTTPIFASRDE 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  602 LIRYAAATHMLSDISSAMANGNWEEAKELAQCAKRDWNRLKNHP-SLRCHEDLPLFLRCFTVGWIYTRILSRFVEILQRL 680
Cdd:cd22326   234 LLRYEEALELEEELDELLENKKWEDAKELLELAKRVWERLKEEVlALRSEEDLPEFLRRFTAGWVYTRILSKGVEALEKL 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  681 HMYEEAVRELESLLSQRIYCPDSRGRWWDRLALNLHQHLKR--LEPTIKCITEGLADPEVRTGHRLSLYQRAVRLRESPS 758
Cdd:cd22326   314 KEYEEAVELLEALLAQRRWRRGKRGRWYDRLALILMTHLKKdsLEEALEVLIEGLADPDVRLGHRLALLRRALRLEKSLR 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  759 --CKKFKHLFQQLPEMA--VQDVKHVTITGRLCPQR--GMCKSVFVMEAGeaaDPTTVLCSVEELALAHYRRSGFDQGIH 832
Cdd:cd22326   394 giPKKLKHLFEELLLDAalLKDIKEVTIKGRLLPSEeaGGKKSVFVGEDK---DRDGEEVSVEELALQHYEDEGFWKGFH 470
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  833 GEGSTFSTLYGLLLWDIIFMDgIPDVFRNACQAFPLDLCTDSFFTSRRPALEARLQLIHDAPEESLRAWVAATWHEQEGR 912
Cdd:cd22326   471 SEGSILTTLFGLLFWDIIFAP-VPGAFETPYQTAPLDLATDSFYYARKDLIEARLEEIEEGSAEELEELVEDTWREREGE 549
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012  913 VASLVSWDRFtSLQQAQDLVSCLGGPVLSGVCRHLAADFRHCRGGLPDLVVWNSQSRHFKLVEVKGPNDRLSHKQMIWLA 992
Cdd:cd22326   550 WCVGVNWDLF-SLEDLLEIVECLGGKALAVICRLLAEDYRHCSGGFPDLLLWNPETKKCKFVEVKGPGDRLSEKQKLWLD 628
                         650       660
                  ....*....|....*....|....*
gi 160410012  993 ELQKLGAEVEVCHVVAvGAKSQSLS 1017
Cdd:cd22326   629 VLLRAGVDVEVCHVVE-EAKSKKLK 652
VRR_NUC pfam08774
VRR-NUC domain;
893-1008 4.02e-38

VRR-NUC domain;


Pssm-ID: 430209  Cd Length: 115  Bit Score: 137.97  E-value: 4.02e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012   893 APEESLRAWVAATWHEQEGRVASLVSWDRFTSLQQaqDLVSCLGGPVLSGVCRHLAADFRHCRGGLPDLVVWNSQSRH-F 971
Cdd:pfam08774    1 NKEGSIEVAIAETLELKRGLPLPGVNWGELSEELE--QALQCLPGEALAAWFRRLAQDYRGLGSGRPDLVLWNPEQKRvF 78
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 160410012   972 KLVEVKGPNDRLSHKQMIWLAELQKLGAEVEVCHVVA 1008
Cdd:pfam08774   79 LLVEVKGPGDRLSDNQRAWIDELRRSGVRVEVCRVAA 115
VRR_NUC smart00990
This model contains proteins with the VRR-NUC domain; It is associated with members of the PD- ...
893-1008 5.56e-33

This model contains proteins with the VRR-NUC domain; It is associated with members of the PD-(D/E)XK nuclease superfamily, which include the type III restriction modification enzymes, for example StyLTI.


Pssm-ID: 214959  Cd Length: 108  Bit Score: 123.00  E-value: 5.56e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160410012    893 APEESLRAWVAATWHEQegrvASLVSWdrftSLQQAQDLVSCLGGPVLSGVCRHLAADFRHCRGGLPDLVVWNSQSRHFK 972
Cdd:smart00990    1 MTEGKALVLIDDRFDIE----NPLVRW----PLEGLSLLLDCLPVKALKGIAGRFASDYPGLRGGVPDLILFLPQDGRYR 72
                            90       100       110
                    ....*....|....*....|....*....|....*.
gi 160410012    973 LVEVKGPNDRLSHKQMIWLAELQKLGAEVEVCHVVA 1008
Cdd:smart00990   73 FVEVKGPGDRLSPLQKRWIDRLAGLGFRVEVCDVVE 108
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
41-62 3.32e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 41.44  E-value: 3.32e-05
                            10        20
                    ....*....|....*....|..
gi 160410012     41 KLACPVCSKMVPRYDLNRHLDE 62
Cdd:smart00734    1 LVQCPVCFREVPENLINSHLDS 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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