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Conserved domains on  [gi|14194541|sp|Q9YGK2|]
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RecName: Full=Pro-opiomelanocortin; Short=POMC; AltName: Full=Corticotropin-lipotropin; Contains: RecName: Full=Corticotropin; AltName: Full=Adrenocorticotropic hormone; Short=ACTH; Contains: RecName: Full=Melanocyte-stimulating hormone alpha; Short=Alpha-MSH; AltName: Full=Melanotropin alpha; Contains: RecName: Full=Corticotropin-like intermediary peptide; Short=CLIP; Contains: RecName: Full=Lipotropin beta; AltName: Full=Beta-LPH; Contains: RecName: Full=Lipotropin gamma; AltName: Full=Gamma-LPH; Contains: RecName: Full=Melanocyte-stimulating hormone beta; Short=Beta-MSH; AltName: Full=Melanotropin beta; Contains: RecName: Full=Beta-endorphin; Contains: RecName: Full=Met-enkephalin; Flags: Precursor

Protein Classification

NPP and Op_neuropeptide domain-containing protein( domain architecture ID 10551814)

protein containing domains NPP, ACTH_domain, and Op_neuropeptide

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NPP pfam08384
Pro-opiomelanocortin, N-terminal region; This family features the N-terminal peptide of ...
 23-63 2.04e-21

Pro-opiomelanocortin, N-terminal region; This family features the N-terminal peptide of pro-opiomelanocortin (NPP). It is thought to represent an important pituitary peptide, given its high yield from pituitary glands, and exhibits a potent in vitro aldosterone-stimulating activity.


:

Pssm-ID: 429962  Cd Length: 43  Bit Score: 83.23  E-value: 2.04e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 14194541    23 CWEHPSCQELNSDSSMMECIQLCHSDLTAEKPVIPGNAHLQ 63
Cdd:pfam08384   1 CWEHSSCQDLSSEAGIMECIQLCRSDLSAESPVFPGNGHLQ 41
Op_neuropeptide pfam08035
Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a ...
 191-220 1.49e-16

Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a wide variety of opioid neuropeptides such as enkephalin.


:

Pssm-ID: 462343  Cd Length: 30  Bit Score: 70.16  E-value: 1.49e-16
                          10        20        30
                  ....*....|....*....|....*....|
gi 14194541   191 YGGFMKSWDERSQRPLLTLFKNVINKDGQQ 220
Cdd:pfam08035   1 YGGFMKSWDERSQKPLITLFKNVIVKDGQK 30
ACTH_domain pfam00976
Corticotropin ACTH domain;
172-190 1.28e-06

Corticotropin ACTH domain;


:

Pssm-ID: 460014  Cd Length: 19  Bit Score: 43.41  E-value: 1.28e-06
                          10
                  ....*....|....*....
gi 14194541   172 DGSYKMKHFRWSGPPASKR 190
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSKR 19
ACTH_domain super family cl03048
Corticotropin ACTH domain;
94-109 2.16e-03

Corticotropin ACTH domain;


The actual alignment was detected with superfamily member pfam00976:

Pssm-ID: 460014  Cd Length: 19  Bit Score: 34.55  E-value: 2.16e-03
                          10
                  ....*....|....*.
gi 14194541    94 YSMEHFRWGKPVGRKR 109
Cdd:pfam00976   4 YKMEHFRWGSPPKSKR 19
 
Name Accession Description Interval E-value
NPP pfam08384
Pro-opiomelanocortin, N-terminal region; This family features the N-terminal peptide of ...
 23-63 2.04e-21

Pro-opiomelanocortin, N-terminal region; This family features the N-terminal peptide of pro-opiomelanocortin (NPP). It is thought to represent an important pituitary peptide, given its high yield from pituitary glands, and exhibits a potent in vitro aldosterone-stimulating activity.


Pssm-ID: 429962  Cd Length: 43  Bit Score: 83.23  E-value: 2.04e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 14194541    23 CWEHPSCQELNSDSSMMECIQLCHSDLTAEKPVIPGNAHLQ 63
Cdd:pfam08384   1 CWEHSSCQDLSSEAGIMECIQLCRSDLSAESPVFPGNGHLQ 41
Op_neuropeptide pfam08035
Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a ...
 191-220 1.49e-16

Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a wide variety of opioid neuropeptides such as enkephalin.


Pssm-ID: 462343  Cd Length: 30  Bit Score: 70.16  E-value: 1.49e-16
                          10        20        30
                  ....*....|....*....|....*....|
gi 14194541   191 YGGFMKSWDERSQRPLLTLFKNVINKDGQQ 220
Cdd:pfam08035   1 YGGFMKSWDERSQKPLITLFKNVIVKDGQK 30
ACTH_domain pfam00976
Corticotropin ACTH domain;
172-190 1.28e-06

Corticotropin ACTH domain;


Pssm-ID: 460014  Cd Length: 19  Bit Score: 43.41  E-value: 1.28e-06
                          10
                  ....*....|....*....
gi 14194541   172 DGSYKMKHFRWSGPPASKR 190
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSKR 19
ACTH_domain pfam00976
Corticotropin ACTH domain;
94-109 2.16e-03

Corticotropin ACTH domain;


Pssm-ID: 460014  Cd Length: 19  Bit Score: 34.55  E-value: 2.16e-03
                          10
                  ....*....|....*.
gi 14194541    94 YSMEHFRWGKPVGRKR 109
Cdd:pfam00976   4 YKMEHFRWGSPPKSKR 19
 
Name Accession Description Interval E-value
NPP pfam08384
Pro-opiomelanocortin, N-terminal region; This family features the N-terminal peptide of ...
 23-63 2.04e-21

Pro-opiomelanocortin, N-terminal region; This family features the N-terminal peptide of pro-opiomelanocortin (NPP). It is thought to represent an important pituitary peptide, given its high yield from pituitary glands, and exhibits a potent in vitro aldosterone-stimulating activity.


Pssm-ID: 429962  Cd Length: 43  Bit Score: 83.23  E-value: 2.04e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 14194541    23 CWEHPSCQELNSDSSMMECIQLCHSDLTAEKPVIPGNAHLQ 63
Cdd:pfam08384   1 CWEHSSCQDLSSEAGIMECIQLCRSDLSAESPVFPGNGHLQ 41
Op_neuropeptide pfam08035
Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a ...
 191-220 1.49e-16

Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a wide variety of opioid neuropeptides such as enkephalin.


Pssm-ID: 462343  Cd Length: 30  Bit Score: 70.16  E-value: 1.49e-16
                          10        20        30
                  ....*....|....*....|....*....|
gi 14194541   191 YGGFMKSWDERSQRPLLTLFKNVINKDGQQ 220
Cdd:pfam08035   1 YGGFMKSWDERSQKPLITLFKNVIVKDGQK 30
ACTH_domain pfam00976
Corticotropin ACTH domain;
172-190 1.28e-06

Corticotropin ACTH domain;


Pssm-ID: 460014  Cd Length: 19  Bit Score: 43.41  E-value: 1.28e-06
                          10
                  ....*....|....*....
gi 14194541   172 DGSYKMKHFRWSGPPASKR 190
Cdd:pfam00976   1 DGKYKMEHFRWGSPPKSKR 19
ACTH_domain pfam00976
Corticotropin ACTH domain;
94-109 2.16e-03

Corticotropin ACTH domain;


Pssm-ID: 460014  Cd Length: 19  Bit Score: 34.55  E-value: 2.16e-03
                          10
                  ....*....|....*.
gi 14194541    94 YSMEHFRWGKPVGRKR 109
Cdd:pfam00976   4 YKMEHFRWGSPPKSKR 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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