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Conserved domains on  [gi|13629390|sp|Q9Z984|]
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RecName: Full=Pyruvate kinase; Short=PK

Protein Classification

pyruvate kinase( domain architecture ID 11490147)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

CATH:  2.40.33.10|3.20.20.60|3.40.1380.20
EC:  2.7.1.40
Gene Ontology:  GO:0004743|GO:0006096|GO:0005524|GO:0030955|GO:0000287
PubMed:  31342570
SCOP:  4003255|4002474|4000500

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 4-469 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


:

Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 684.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390     4 RTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLAIMLDTKGPEIRLGNIPQ-PI 82
Cdd:TIGR01064   2 RTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGgEV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390    83 SVSQGQKLRLVSSDI--DGSAEGGVSLYpKGIFPFVPEGADVLIDDGYIHAVVVSSEADSLELEFMNSGLLKSHKSLSIR 160
Cdd:TIGR01064  82 KLKKGDKVIITTDDIkgEGDEEKVYVDY-KGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   161 GVDVALPFMTEKDIADLKFGVEQNMDVVAASFVRYGEDIETMRKCLADLGNPKMPIIAKIENRLGVENFSKIAKLADGIM 240
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDGIM 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   241 IARGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSGETASGAHP 320
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   321 VAAVKIMRSVILETEKNLSHDSFLKlDDSNSALQVSPYLSAIGLAGIQIAERADAKALIVYTESGSSPMFLSKYRPKFPI 400
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLTNFN-DRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPI 399

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13629390   401 IAVTPSTSVYYRLALEWGVYPMLTQE--SDRAVWRHQACIYGIEQGILSNYDRILVLSRG--ACMEETNNLTL 469
Cdd:TIGR01064 400 IAVTPNERVARQLALYWGVFPFLVDEepSDTDARVNKALELLKEKGIVKKGDLVVVIQGGpiGGEGGTNTIRV 472
 
Name Accession Description Interval E-value
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 4-469 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 684.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390     4 RTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLAIMLDTKGPEIRLGNIPQ-PI 82
Cdd:TIGR01064   2 RTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGgEV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390    83 SVSQGQKLRLVSSDI--DGSAEGGVSLYpKGIFPFVPEGADVLIDDGYIHAVVVSSEADSLELEFMNSGLLKSHKSLSIR 160
Cdd:TIGR01064  82 KLKKGDKVIITTDDIkgEGDEEKVYVDY-KGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   161 GVDVALPFMTEKDIADLKFGVEQNMDVVAASFVRYGEDIETMRKCLADLGNPKMPIIAKIENRLGVENFSKIAKLADGIM 240
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDGIM 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   241 IARGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSGETASGAHP 320
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   321 VAAVKIMRSVILETEKNLSHDSFLKlDDSNSALQVSPYLSAIGLAGIQIAERADAKALIVYTESGSSPMFLSKYRPKFPI 400
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLTNFN-DRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPI 399

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13629390   401 IAVTPSTSVYYRLALEWGVYPMLTQE--SDRAVWRHQACIYGIEQGILSNYDRILVLSRG--ACMEETNNLTL 469
Cdd:TIGR01064 400 IAVTPNERVARQLALYWGVFPFLVDEepSDTDARVNKALELLKEKGIVKKGDLVVVIQGGpiGGEGGTNTIRV 472
PRK05826 PRK05826
pyruvate kinase; Provisional
 1-459 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 622.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390    1 MITRTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLAIMLDTKGPEIRLGNIPQ 80
Cdd:PRK05826   2 MLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   81 -PISVSQGQKLRLVSSDIDGSAEGGVSLYPKGIFPFVPEGADVLIDDGYIHAVVVSSEADSLELEFMNSGLLKSHKSLSI 159
Cdd:PRK05826  82 gKITLKTGDKFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  160 RGVDVALPFMTEKDIADLKFGVEQNMDVVAASFVRYGEDIETMRKCLADLGNPKMPIIAKIENRLGVENFSKIAKLADGI 239
Cdd:PRK05826 162 PGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAKIERAEAVDNIDEIIEASDGI 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  240 MIARGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSGETASGAH 319
Cdd:PRK05826 242 MVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKY 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  320 PVAAVKIMRSVILETEKNLS-----HDSFLKLDDSNSALQVSPYLSAIGLAGIqiaeradaKALIVYTESGSSPMFLSKY 394
Cdd:PRK05826 322 PVEAVEAMARICKGAEKEFSinlskHRLDRQFDRIDEAIAMSAMYAANHLKGV--------KAIVALTESGRTARLISRF 393

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13629390  395 RPKFPIIAVTPSTSVYYRLALEWGVYPMLTQES-DRAVWRHQACIYGIEQGILSNYDRILVLSRGA 459
Cdd:PRK05826 394 RPGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAaDTDDAAEEALRLLLEKGLVESGDLVVVTSGDP 459
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 1-456 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 584.69  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   1 MITRTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLAIMLDTKGPEIRLGNIPQ 80
Cdd:COG0469   1 MMRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  81 -PISVSQGQKLRLVSSDIDGSAEGgVSLYPKGIFPFVPEGADVLIDDGYIHAVVVSSEADSLELEFMNSGLLKSHKSLSI 159
Cdd:COG0469  81 gPVELKKGDTFTLTTDDVEGDAER-VSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390 160 RGVDVALPFMTEKDIADLKFGVEQNMDVVAASFVRYGEDIETMRKCLADLGNpKMPIIAKIENRLGVENFSKIAKLADGI 239
Cdd:COG0469 160 PGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGG-RAPIIAKIEKPEAVENLDEIIEASDGI 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390 240 MIARGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSGETASGAH 319
Cdd:COG0469 239 MVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKY 318

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390 320 PVAAVKIMRSVILETEKNLSHDSFLKLDDSNSALQVSpylSAIGLAGIQIAERADAKALIVYTESGSSPMFLSKYRPKFP 399
Cdd:COG0469 319 PVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTIT---DAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVP 395

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 13629390 400 IIAVTPSTSVYYRLALEWGVYPMLTQE-SDRAVWRHQACIYGIEQGILSNYDRILVLS 456
Cdd:COG0469 396 ILALTPNERTARRLALVWGVYPVLVDDvESTDEMIEEAVEALLEEGLVKPGDLVVITA 453
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 4-458 7.14e-158

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 456.78  E-value: 7.14e-158
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   4 RTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLAIMLDTKGPEIRLGNIP--QP 81
Cdd:cd00288   3 RTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKggKD 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  82 ISVSQGQKLRLvssDIDGSAEGG----VSLYPKGIFPFVPEGADVLIDDGYIHAVVVSSEADS-LELEFMNSGLLKSHKS 156
Cdd:cd00288  83 ISLKAGDKFLV---TTDPAAKKGtkekIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKG 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390 157 LSIRGVDVALPFMTEKDIADLKFGVEQNMDVVAASFVRYGEDIETMRKCLADLGnPKMPIIAKIENRLGVENFSKIAKLA 236
Cdd:cd00288 160 VNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKG-KDIKIIAKIENQEGVNNFDEILEAS 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390 237 DGIMIARGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSGETAS 316
Cdd:cd00288 239 DGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 318

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390 317 GAHPVAAVKIMRSVILETEKNLSHDSFLKLDDSNSALQVSPyLSAIGLAGIQIAERADAKALIVYTESGSSPMFLSKYRP 396
Cdd:cd00288 319 GKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTST-TEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRP 397

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13629390 397 KFPIIAVTPSTSVYYRLALEWGVYPMLTqESDRAVWRHQ-------ACIYGIEQGILSNYDRILVLSRG 458
Cdd:cd00288 398 NAPIIAVTRNEQTARQLHLYRGVYPVLF-EEPKPGWQEDtdarlkaAVNVAKEKGLLKKGDLVVVVQGW 465
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 4-340 1.13e-130

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 382.49  E-value: 1.13e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390     4 RTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLAIMLDTKGPEIRLGNI---PQ 80
Cdd:pfam00224   3 RTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTkdgKK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390    81 PISVSQGQKLRLVSSDIDGSA--EGGVSLYPKGIFPFVPEGADVLIDDGYIHAVVVSSEADS-LELEFMNSGLLKSHKSL 157
Cdd:pfam00224  83 DIELKAGDEMIVSTDAKYKGAcdDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSRKGV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   158 SIRGVDVALPFMTEKDIADLKFGVEQNMDVVAASFVRYGEDIETMRKCLADLGnPKMPIIAKIENRLGVENFSKIAKLAD 237
Cdd:pfam00224 163 NLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAG-KNIQIIAKIENQEGVNNFDEILEATD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   238 GIMIARGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSGETASG 317
Cdd:pfam00224 242 GIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 321

                         330       340
                  ....*....|....*....|...
gi 13629390   318 AHPVAAVKIMRSVILETEKNLSH 340
Cdd:pfam00224 322 NYPVEAVRMMHEICLEAEKALPH 344
 
Name Accession Description Interval E-value
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 4-469 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 684.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390     4 RTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLAIMLDTKGPEIRLGNIPQ-PI 82
Cdd:TIGR01064   2 RTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGgEV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390    83 SVSQGQKLRLVSSDI--DGSAEGGVSLYpKGIFPFVPEGADVLIDDGYIHAVVVSSEADSLELEFMNSGLLKSHKSLSIR 160
Cdd:TIGR01064  82 KLKKGDKVIITTDDIkgEGDEEKVYVDY-KGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   161 GVDVALPFMTEKDIADLKFGVEQNMDVVAASFVRYGEDIETMRKCLADLGNPKMPIIAKIENRLGVENFSKIAKLADGIM 240
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDGIM 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   241 IARGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSGETASGAHP 320
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   321 VAAVKIMRSVILETEKNLSHDSFLKlDDSNSALQVSPYLSAIGLAGIQIAERADAKALIVYTESGSSPMFLSKYRPKFPI 400
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLTNFN-DRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPI 399

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13629390   401 IAVTPSTSVYYRLALEWGVYPMLTQE--SDRAVWRHQACIYGIEQGILSNYDRILVLSRG--ACMEETNNLTL 469
Cdd:TIGR01064 400 IAVTPNERVARQLALYWGVFPFLVDEepSDTDARVNKALELLKEKGIVKKGDLVVVIQGGpiGGEGGTNTIRV 472
PRK05826 PRK05826
pyruvate kinase; Provisional
 1-459 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 622.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390    1 MITRTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLAIMLDTKGPEIRLGNIPQ 80
Cdd:PRK05826   2 MLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   81 -PISVSQGQKLRLVSSDIDGSAEGGVSLYPKGIFPFVPEGADVLIDDGYIHAVVVSSEADSLELEFMNSGLLKSHKSLSI 159
Cdd:PRK05826  82 gKITLKTGDKFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  160 RGVDVALPFMTEKDIADLKFGVEQNMDVVAASFVRYGEDIETMRKCLADLGNPKMPIIAKIENRLGVENFSKIAKLADGI 239
Cdd:PRK05826 162 PGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAKIERAEAVDNIDEIIEASDGI 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  240 MIARGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSGETASGAH 319
Cdd:PRK05826 242 MVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKY 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  320 PVAAVKIMRSVILETEKNLS-----HDSFLKLDDSNSALQVSPYLSAIGLAGIqiaeradaKALIVYTESGSSPMFLSKY 394
Cdd:PRK05826 322 PVEAVEAMARICKGAEKEFSinlskHRLDRQFDRIDEAIAMSAMYAANHLKGV--------KAIVALTESGRTARLISRF 393

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13629390  395 RPKFPIIAVTPSTSVYYRLALEWGVYPMLTQES-DRAVWRHQACIYGIEQGILSNYDRILVLSRGA 459
Cdd:PRK05826 394 RPGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAaDTDDAAEEALRLLLEKGLVESGDLVVVTSGDP 459
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 1-456 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 584.69  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   1 MITRTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLAIMLDTKGPEIRLGNIPQ 80
Cdd:COG0469   1 MMRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  81 -PISVSQGQKLRLVSSDIDGSAEGgVSLYPKGIFPFVPEGADVLIDDGYIHAVVVSSEADSLELEFMNSGLLKSHKSLSI 159
Cdd:COG0469  81 gPVELKKGDTFTLTTDDVEGDAER-VSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390 160 RGVDVALPFMTEKDIADLKFGVEQNMDVVAASFVRYGEDIETMRKCLADLGNpKMPIIAKIENRLGVENFSKIAKLADGI 239
Cdd:COG0469 160 PGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGG-RAPIIAKIEKPEAVENLDEIIEASDGI 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390 240 MIARGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSGETASGAH 319
Cdd:COG0469 239 MVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKY 318

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390 320 PVAAVKIMRSVILETEKNLSHDSFLKLDDSNSALQVSpylSAIGLAGIQIAERADAKALIVYTESGSSPMFLSKYRPKFP 399
Cdd:COG0469 319 PVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTIT---DAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVP 395

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 13629390 400 IIAVTPSTSVYYRLALEWGVYPMLTQE-SDRAVWRHQACIYGIEQGILSNYDRILVLS 456
Cdd:COG0469 396 ILALTPNERTARRLALVWGVYPVLVDDvESTDEMIEEAVEALLEEGLVKPGDLVVITA 453
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 4-458 7.14e-158

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 456.78  E-value: 7.14e-158
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   4 RTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLAIMLDTKGPEIRLGNIP--QP 81
Cdd:cd00288   3 RTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKggKD 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  82 ISVSQGQKLRLvssDIDGSAEGG----VSLYPKGIFPFVPEGADVLIDDGYIHAVVVSSEADS-LELEFMNSGLLKSHKS 156
Cdd:cd00288  83 ISLKAGDKFLV---TTDPAAKKGtkekIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKG 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390 157 LSIRGVDVALPFMTEKDIADLKFGVEQNMDVVAASFVRYGEDIETMRKCLADLGnPKMPIIAKIENRLGVENFSKIAKLA 236
Cdd:cd00288 160 VNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKG-KDIKIIAKIENQEGVNNFDEILEAS 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390 237 DGIMIARGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSGETAS 316
Cdd:cd00288 239 DGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 318

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390 317 GAHPVAAVKIMRSVILETEKNLSHDSFLKLDDSNSALQVSPyLSAIGLAGIQIAERADAKALIVYTESGSSPMFLSKYRP 396
Cdd:cd00288 319 GKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTST-TEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRP 397

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13629390 397 KFPIIAVTPSTSVYYRLALEWGVYPMLTqESDRAVWRHQ-------ACIYGIEQGILSNYDRILVLSRG 458
Cdd:cd00288 398 NAPIIAVTRNEQTARQLHLYRGVYPVLF-EEPKPGWQEDtdarlkaAVNVAKEKGLLKKGDLVVVVQGW 465
PRK06354 PRK06354
pyruvate kinase; Provisional
 1-476 1.74e-146

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 431.66  E-value: 1.74e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390    1 MITRTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLAIMLDTKGPEIRLGNIP- 79
Cdd:PRK06354   6 LMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEd 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   80 QPISVSQGQKLRLVSSDIDGSAEGGVSLYPKGIFPfVPEGADVLIDDGYIHAVVVSSEADSLELE--FMNSGLLKSHKSL 157
Cdd:PRK06354  86 GPIELKTGDEFILTSREVLGTQEKFSVTYDGLADE-VPVGSRILLDDGLIELEVEEVDKADGELHckVLVGGVLSNKKGV 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  158 SIRGVDVALPFMTEKDIADLKFGVEQNMDVVAASFVRYGEDIETMRKCLADLGNPKMPIIAKIENRLGVENFSKIAKLAD 237
Cdd:PRK06354 165 NFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIPIIAKIEKQEAIDNIDAILELCD 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  238 GIMIARGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSGETASG 317
Cdd:PRK06354 245 GLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAG 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  318 AHPVAAVKIMRSVILETEKNLSHDSFLklddSNSALQVSPYLSAIGLAGIQIAERADAKALIVYTESGSSPMFLSKYRPK 397
Cdd:PRK06354 325 DYPVEAVQTMATIAVRIEKDLPYRDIL----SKRPEFTTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPK 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  398 FPIIAVTPSTSVYYRLALEWGVYPMLTQESDRAVWRHQACI-YGIEQGILSNYDRIlVLSRGACMEE---TNNLTLTIVN 473
Cdd:PRK06354 401 TPILAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAInVAQESGLLKQGDLV-VITAGTLVGEsgsTDLMKVHVVG 479


                 ...
gi 13629390  474 DIL 476
Cdd:PRK06354 480 AVV 482
PRK06247 PRK06247
pyruvate kinase; Provisional
 4-454 1.27e-136

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 402.38  E-value: 1.27e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390    4 RTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLAIMLDTKGPEIRLGNIPQ-PI 82
Cdd:PRK06247   6 RVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFADgKV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   83 SVSQGQKLRLVSSDIDGSAEGgVSLYPKGIFPFVPEGADVLIDDGYIHAVVVSSEADSLELEFMNSGLLKSHKSLSIRGV 162
Cdd:PRK06247  86 QLANGQTFRLDVDDAPGDHDR-VSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSLPGT 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  163 DVALPFMTEKDIADLKFGVEQNMDVVAASFVRYGEDIETMRKCLADlgnpKMPIIAKIENRLGVENFSKIAKLADGIMIA 242
Cdd:PRK06247 165 VLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGG----RVPVMAKIEKPQAIDRLEAIVEASDAIMVA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  243 RGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSGETASGAHPVA 322
Cdd:PRK06247 241 RGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVE 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  323 AVKIMRSVILETEKN-----LSHDSFLKLDDSNSalqvspylSAIGLAGIQIAERADAKALIVYTESGSSPMFLSKYRPK 397
Cdd:PRK06247 321 AVRTMARIIRQVERDptyppLIHAQRPQPEATKR--------DAISYAARDIAERLDLAALVAYTSSGDTALRAARERPP 392

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  398 FPIIAVTPSTSVYYRLALEWGVYPMLTQE---SDRAVwrHQACIYGIEQGILSNYDRILV 454
Cdd:PRK06247 393 LPILALTPNPETARRLALTWGVHCVVVDDardTDDMV--RRADRIALAEGFYKRGDRVVI 450
PRK09206 PRK09206
pyruvate kinase PykF;
2-428 4.48e-132

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 390.57  E-value: 4.48e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390    2 ITRTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLAIMLDTKGPEIRLGNIP-- 79
Cdd:PRK09206   1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEgg 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   80 QPISVSQGQKLrLVSSDID--GSAEGGVSLYPkGIFPFVPEGADVLIDDGYIHAVVVSSEADSLELEFMNSGLLKSHKSL 157
Cdd:PRK09206  81 NDVSLKAGQTF-TFTTDKSvvGNKERVAVTYE-GFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  158 SIRGVDVALPFMTEKDIADLKFGVEQNMDVVAASFVRYGEDIETMRKCLADLGNPKMPIIAKIENRLGVENFSKIAKLAD 237
Cdd:PRK09206 159 NLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGENIQIISKIENQEGLNNFDEILEASD 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  238 GIMIARGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSGETASG 317
Cdd:PRK09206 239 GIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKG 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  318 AHPVAAVKIMRSVILETeknlshDSFLK--LDDSN--SALQVSpylSAIGLAGIQIAERADAKALIVYTESGSSPMFLSK 393
Cdd:PRK09206 319 KYPLEAVSIMATICERT------DRVMNsrLESNNdnRKLRIT---EAVCRGAVETAEKLDAPLIVVATQGGKSARSVRK 389

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 13629390  394 YRPKFPIIAVTPSTSVYYRLALEWGVYPMLTQESD 428
Cdd:PRK09206 390 YFPDATILALTTNEKTARQLVLSKGVVPQLVKEIA 424
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 4-340 1.13e-130

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 382.49  E-value: 1.13e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390     4 RTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLAIMLDTKGPEIRLGNI---PQ 80
Cdd:pfam00224   3 RTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTkdgKK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390    81 PISVSQGQKLRLVSSDIDGSA--EGGVSLYPKGIFPFVPEGADVLIDDGYIHAVVVSSEADS-LELEFMNSGLLKSHKSL 157
Cdd:pfam00224  83 DIELKAGDEMIVSTDAKYKGAcdDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSRKGV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   158 SIRGVDVALPFMTEKDIADLKFGVEQNMDVVAASFVRYGEDIETMRKCLADLGnPKMPIIAKIENRLGVENFSKIAKLAD 237
Cdd:pfam00224 163 NLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAG-KNIQIIAKIENQEGVNNFDEILEATD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   238 GIMIARGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSGETASG 317
Cdd:pfam00224 242 GIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 321

                         330       340
                  ....*....|....*....|...
gi 13629390   318 AHPVAAVKIMRSVILETEKNLSH 340
Cdd:pfam00224 322 NYPVEAVRMMHEICLEAEKALPH 344
PLN02461 PLN02461
Probable pyruvate kinase
 4-457 1.73e-113

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 344.27  E-value: 1.73e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390    4 RTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLAIMLDTKGPEIRLGNIP--QP 81
Cdd:PLN02461  22 KTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLKdgKP 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   82 ISVSQGQKLRLVssdIDGSAEGGVSL----YPKgIFPFVPEGADVLIDDGYIHAVVVSS--EADSLELEFMNSGLLKSHK 155
Cdd:PLN02461 102 VQLKQGQEITIT---TDYSIKGDENMiamsYKK-LAVDVKPGSVILCADGTITLTVLSCdvEAGTVRCRCENSAMLGERK 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  156 SLSIRGVDVALPFMTEKDIAD-LKFGVEQNMDVVAASFVRYGEDIETMRKCLADLGNpKMPIIAKIENRLGVENFSKIAK 234
Cdd:PLN02461 178 NVNLPGVVVDLPTLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAK-SILLISKVENQEGLDNFDDILA 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  235 LADGIMIARGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSGET 314
Cdd:PLN02461 257 ESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGET 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  315 ASGAHPVAAVKIMRSVILETEKNLSHDSFLKLDDSNSALQVSPyLSAIGLAGIQIAERADAKALIVYTESGSSPMFLSKY 394
Cdd:PLN02461 337 AAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSP-LESLASSAVRTANKVKASLIVVLTRGGTTARLVAKY 415

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  395 RPKFPIIAV------------TPSTSVYYRLALEW-GVYPMLTQESDRAVWRH------QACI-YGIEQGILSNYDRILV 454
Cdd:PLN02461 416 RPAVPILSVvvpeittdsfdwSCSDEAPARHSLIYrGLIPVLAEGSAKATDSEsteeilEAAIeHAKKKGLCKPGDSVVA 495


                 ...
gi 13629390  455 LSR 457
Cdd:PLN02461 496 LHR 498
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 4-419 1.92e-109

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 334.04  E-value: 1.92e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390    4 RTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKElrEQKRVP---LAIMLDTKGPEIRLGNI-- 78
Cdd:PTZ00066  39 KTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVRE--AAKARPnanLGILLDTKGPEIRTGFLkn 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   79 PQPISVSQGQKLRLVSS-DIDGSAEGGVSLYPKgIFPFVPEGADVLIDDGYIHAVVVSSEADSLELEFMNSGLLKSHKSL 157
Cdd:PTZ00066 117 HKPITLKEGQTLKITTDyTFLGDETCISCSYKK-LPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNM 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  158 SIRGVDVALPFMTEKDIAD-LKFGVEQNMDVVAASFVRYGEDIETMRKCLADLGNpKMPIIAKIENRLGVENFSKIAKLA 236
Cdd:PTZ00066 196 NLPGVKVELPVIGEKDKNDiLNFAIPMGCDFIALSFVQSADDVRLCRQLLGERGR-HIKIIPKIENIEGLINFDEILAES 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  237 DGIMIARGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSGETAS 316
Cdd:PTZ00066 275 DGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETAN 354

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  317 GAHPVAAVKIMRSVILETEKNLSHdsflKLDDSNSALQVSPYLS---AIGLAGIQIAERADAKALIVYTESGSSPMFLSK 393
Cdd:PTZ00066 355 GKFPVEAVNIMAKICFEAETCIDY----RVLYHAIHLAVPTPVSvqeAVARSAVETAEDINAKLIIALTETGNTARLISK 430

                        410       420
                 ....*....|....*....|....*.
gi 13629390  394 YRPKFPIIAVTPSTSVYYRLALEWGV 419
Cdd:PTZ00066 431 YRPSCTILALSASPSVVKSLSVARGV 456
PLN02623 PLN02623
pyruvate kinase
 4-430 1.66e-104

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 323.42  E-value: 1.66e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390    4 RTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQ-KRVPLAIMLDTKGPEIRLGNIPQPI 82
Cdd:PLN02623 111 KTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQsKDNVIAIMLDTKGPEVRSGDLPQPI 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   83 SVSQGQKL-----RLVSSdidgsaEGGVSLYPKGIFPFVPEGADVLIDDGYIHAVVVSSEADSLELEFMNSGLLKSHKSL 157
Cdd:PLN02623 191 MLEEGQEFtftikRGVST------EDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHL 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  158 SIRGVDVALPFMTEKDIADLKFGVEQNMDVVAASFVRYGEDI----ETMRKCLADLGnpkmpIIAKIENRLGVENFSKIA 233
Cdd:PLN02623 265 NVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVhelkDYLKSCNADIH-----VIVKIESADSIPNLHSII 339

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  234 KLADGIMIARGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSGE 313
Cdd:PLN02623 340 TASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGE 419

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  314 TASGAHPVAAVKIMRSVILETEKNLSHDSflklDDSNSALQVSPYLSAIGLAGIQIAERADAKALIVYTESGSSPMFLSK 393
Cdd:PLN02623 420 TAHGKFPLKAVKVMHTVALRTEATLPEGT----TPPNLGQAFKNHMSEMFAFHATMMANTLGTSIIVFTRTGFMAILLSH 495

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 13629390  394 YRPKFPIIAVTPSTSVYYRLALEWGVYPMLTQESDRA 430
Cdd:PLN02623 496 YRPSGTIFAFTNEKRIQQRLALYQGVCPIYMQFSDDA 532
PRK06739 PRK06739
pyruvate kinase; Validated
 8-330 1.25e-92

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 285.30  E-value: 1.25e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390    8 ICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQkrvpLAIMLDTKGPEIRLGNIP-QPISVSQ 86
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDS----IKILGDVQGPKIRLGEIKgEQITLQA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   87 GQKLRLVSSDIDGSAEGGVSLYpKGIFPFVPEGADVLIDDGYIHAVVVSSEADSLELEFMNSGLLKSHKSLSIRGVDVAL 166
Cdd:PRK06739  82 GDSFILHTQPVTGSSTEASVDY-EGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVRL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  167 PFMTEKDIADLKFGVEQNMDVVAASFVRYGEDIETMRKCLADLGNPKMPIIAKIENRLGVENFSKIAKLADGIMIARGDL 246
Cdd:PRK06739 161 PAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSPNLIAKIETMEAIENFQDICKEADGIMIARGDL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  247 GIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSGETASGAHPVAAVKI 326
Cdd:PRK06739 241 GVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVST 320


                 ....
gi 13629390  327 MRSV 330
Cdd:PRK06739 321 LRLV 324
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 29-419 2.85e-85

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 269.61  E-value: 2.85e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   29 MNVARLNFSHGSHETHGQAIGFLKELREQKRVPLAIMLDTKGPEIRLGNIPQPISVSQGQKLRLVSSDIDGSAEGGVSLY 108
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDPAFADKGTKDKF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  109 -------PKGIFPfvpeGADVLIDDGYIHAVVVSSEAD-SLELEFMNSGLLKSHKSLSIRGVDVALPFMTEKDIADLKFG 180
Cdd:PTZ00300  81 yidyqnlSKVVRP----GGYIYIDDGILILHVQSHEDEqTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  181 VEQNMDVVAASFVRYGEDIETMRKCLADLGNPKMpIIAKIENRLGVENFSKIAKLADGIMIARGDLGIELSVVEVPNLQK 260
Cdd:PTZ00300 157 VEQGVDMIFASFIRSAEQVGEVRKALGAKGGDIM-IICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQK 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  261 MMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSGETASGAHPVAAVKIMRSVILETEKNLSH 340
Cdd:PTZ00300 236 ILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNE 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  341 DSFLkldDSNSALQVSPYL--SAIGLAGIQIAERADAKALIVYTESGSSPMFLSKYRPKFPIIAVTPSTSVYYRLALEWG 418
Cdd:PTZ00300 316 YVFF---NSIKKLQPIPMSaeEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQG 392


                 .
gi 13629390  419 V 419
Cdd:PTZ00300 393 V 393
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 4-481 3.95e-84

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 268.54  E-value: 3.95e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390    4 RTKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLAIMLDTKGPEIRLGNIPQPIS 83
Cdd:PLN02762  26 RTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDLGGASS 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   84 V--SQGQKLRLVSSDIDGS-AEGGVSLYPKGIFPFVPEGADVLIDDGYIHAVVVSSEADSLELEFMNSGLLKSHKSLS-- 158
Cdd:PLN02762 106 AkaEDGEEWTFTVRKFDGSrPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTDPGLLLPRANLTfw 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  159 -----IRGVDVALPFMTEKDIADLKFGVEQNMDVVAASFVRYGEDIETMRKCLADLG-NPKMPIIAKIENRLGVENFSKI 232
Cdd:PLN02762 186 rdgslVRERNAMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSrDSDIGVIAKIESLDSLKNLEEI 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  233 AKLADGIMIARGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSG 312
Cdd:PLN02762 266 IRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRADALMLSG 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  313 ETASGAHPVAAVKIMRSVILETEKnLSHDSflKLDDSNSALQVSPYLSA-----IGLAGIQIAERADAKALIVYTESGSS 387
Cdd:PLN02762 346 ESAMGLYPEKALSVLRSVSLRMEL-WSREE--KRHEALELPQLSSSLSDriseeICNSAAKMANNLGVDAIFVYTKHGHM 422

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  388 PMFLSKYRPKFPIIAVTPSTSVYYRLALEWGVYPMLTQESDravwrhqaciygieqGILSNYDRILVLSRGACMEETNNL 467
Cdd:PLN02762 423 ASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSD---------------DMESNLNKTFSLLKARGMIKSGDL 487

                        490
                 ....*....|....
gi 13629390  468 TLtIVNDILTGSEF 481
Cdd:PLN02762 488 VI-AVSDLTPSSML 500
PLN02765 PLN02765
pyruvate kinase
 5-454 2.08e-71

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 235.72  E-value: 2.08e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390    5 TKIICTIGPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLAIMLDTKGPEIRLGNIP-QPIS 83
Cdd:PLN02765  30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTeKPIS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   84 VSQGQKLRLVSsdiDGSAEGGVSLYP---KGIFPFVPEGADVLIDDgYIhavVVSSEADSLELEFM------------NS 148
Cdd:PLN02765 110 LKAGNTVTLTP---DQSKEASSEVLPinfPGLAKAVKPGDTIFVGQ-YL---FTGSETTSVWLEVDevkgddvvctvkNS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  149 GLLK-SHKSLSIRGVDVALPFMTEKDIADLK-FGVEQNMDVVAASFVRYGEDIETMRKCLADLGNPKMPIIAKIENRLGV 226
Cdd:PLN02765 183 ATLAgSLFTLHVSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLSQTQIFAKIENVEGL 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  227 ENFSKIAKLADGIMIARGDLGIELSVVEVPNLQKMMAKVSRETGHFCVTaTQMLESMIRNVLPTRAEVSDIANAIYDGSS 306
Cdd:PLN02765 263 THFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGAD 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  307 AVMLSGETASGAHPVAAVKIMRSVILETEKNLSHDSFLKlddsnsalQVSPY-------LSAIGLAGIQIAERADAKALI 379
Cdd:PLN02765 342 AILLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYFK--------KTVKYvgepmshLESIASSAVRAAIKVKASVII 413

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  380 VYTESGSSPMFLSKYRPKFPIIAVtpstsVYYRL---ALEW---------------GVYPML------------TQESDR 429
Cdd:PLN02765 414 VFTSSGRAARLIAKYRPTMPVLSV-----VIPRLktnQLKWsftgafqarqclivrGLFPMLadprhsaestsaTNESVL 488

                        490       500
                 ....*....|....*....|....*
gi 13629390  430 AVwrhqACIYGIEQGILSNYDRILV 454
Cdd:PLN02765 489 KV----ALDHGKAAGVIKSHDRVVV 509
PRK08187 PRK08187
pyruvate kinase; Validated
 4-330 5.16e-47

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 169.81  E-value: 5.16e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390    4 RTKIICTI-GPATNSPEMLAKLLDAGMNVARLNFSHGSHETHGQAIGFLKELREQKRVPLAIMLDTKGPEIRLGNIPQPI 82
Cdd:PRK08187 134 RTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGAVAGPL 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   83 S---VSQGQKLRLVSS---DIDGSAEGGVSLYPKGIFPFVPEGADVLIDDGYIHAVVVSSEADSLELEFMNS---GL-LK 152
Cdd:PRK08187 214 GktrLYTGDRLALVAQgppRRIDEEHFQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLEVTHArpkGLkLK 293

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  153 SHKSLSIRGVDVALPFMTEKDIADLKFgVEQNMDVVAASFVRYGEDIETMRKCLA---DLGNPKMPIIAKIENRLGVENF 229
Cdd:PRK08187 294 PEKGLNFPDTALDLPALTEKDRADLDF-VARHADLVGYSFVQSPGDVEALQAALAarrPDDWRKLGLVLKIETPRAVANL 372

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  230 SKIAKLADG-----IMIARGDLGIELSVVEVPNLQKMMAKVSrETGHFCVT-ATQMLESMIRNVLPTRAEVSDIANAiyd 303
Cdd:PRK08187 373 PELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLC-EAAHVPVIwATQVLEGLVKKGLPSRAEMTDAAMA--- 448

                        330       340
                 ....*....|....*....|....*....
gi 13629390  304 gSSA--VMLSgetaSGAHPVAAVKIMRSV 330
Cdd:PRK08187 449 -ARAecVMLN----KGPYLVEAVTFLDDL 472
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
274-427 4.51e-41

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 149.67  E-value: 4.51e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390 274 VTATQMLESMIRNVLPTRAEVSDIANAIYDGSSAVMLSGETASGAHPVAAVKIMRSVILETEKNLSHDSFLKLDDSNSAL 353
Cdd:COG3848  10 ITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQRVPRAKESST 89

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13629390 354 QVspyLSAIGLAGIQIAERADAKALIVYTESGSSPMFLSKYRPKFPIIAVTPSTSVYYRLALEWGVYPMLTQES 427
Cdd:COG3848  90 TI---TDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEES 160
PRK14725 PRK14725
pyruvate kinase; Provisional
 78-333 1.27e-39

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 151.26  E-value: 1.27e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   78 IPQPISVSQGQKLRLVSSDIDG-SAEGGVSLY------PKgIFPFVPEGADVLIDDGYIHAVVVSSEADSLELEFMNSGL 150
Cdd:PRK14725 329 VEQKLRLKVGDRLVLTRDDAPGdPAQGDAPPArisctlPE-AFRAARVGERVWFDDGKIGAVVVKVEADEVELRITHARP 407

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  151 ----LKSHKSLSIRGVDVALPFMTEKDIADLKFgVEQNMDVVAASFVRYGEDIETMRKCLADLGNPKMPIIAKIENRLGV 226
Cdd:PRK14725 408 ggskLKAGKGINLPDSHLPLPALTDKDLEDLAF-VAKHADIVALSFVRSPEDVRLLLDALEKLGADDLGVVLKIETRRAF 486

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390  227 ENFSKI-------AKLadGIMIARGDLGIELS---VVEVPnlQKMMAKVsrETGHFCVT-ATQMLESMIRNVLPTRAEVS 295
Cdd:PRK14725 487 ENLPRIlleamrhPRF--GVMIARGDLAVEVGferLAEVQ--EEILWLC--EAAHVPVIwATQVLESLAKKGLPSRAEIT 560

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 13629390  296 DIANAIYdgSSAVMLSgetaSGAHPVAAVKIMRSvILE 333
Cdd:PRK14725 561 DAAMALR--AECVMLN----KGPHIVEAVRVLDD-ILR 591
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 361-456 9.48e-22

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 90.23  E-value: 9.48e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13629390   361 AIGLAGIQIAERADAKALIVYTESGSSPMFLSKYRPKFPIIAVTPSTSVYYRLALEWGVYPMLT--QESDRAVWRHqACI 438
Cdd:pfam02887   2 AIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFdeAETTDEMLRR-AVK 80

                          90
                  ....*....|....*...
gi 13629390   439 YGIEQGILSNYDRILVLS 456
Cdd:pfam02887  81 VAKEAGLVKKGDLVVITA 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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