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Conserved domains on  [gi|1590460078|gb|QBL54768|]
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NS5A, partial [Hepacivirus hominis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HCV_NS5a_1b super family cl07057
Hepatitis C virus non-structural 5a domain 1b; The molecular function of the non-structural 5a ...
 96-150 5.16e-24

Hepatitis C virus non-structural 5a domain 1b; The molecular function of the non-structural 5a protein is uncertain. The NS5a protein is phosphorylated when expressed in mammalian cells. It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR. This region corresponds to the 1b domain.


The actual alignment was detected with superfamily member pfam08301:

Pssm-ID: 149382  Cd Length: 102  Bit Score: 89.34  E-value: 5.16e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1590460078  96 GPGTPCPSPNYTRALWRVAANSYVEVRRVGDFHYITGATEDELkCPCQVPAAEFF 150
Cdd:pfam08301   1 GPAVPLPPPNYGPALWRVGAEDYVEVVRVGDTHYVTATSCYNL-CPCQVPRPEFF 54
HCV_NS5a pfam01506
Hepatitis C virus non-structural 5a protein membrane anchor; The molecular function of the ...
 2-24 1.16e-07

Hepatitis C virus non-structural 5a protein membrane anchor; The molecular function of the non-structural 5a protein is uncertain. The NS5a protein is phosphorylated when expressed in mammalian cells. It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR. The N-terminal region of the NS5a protein has been used in the construction of the alignment for this family. The C-terminal region has not been included because it is too heterogeneous.


:

Pssm-ID: 366682  Cd Length: 23  Bit Score: 45.27  E-value: 1.16e-07
                          10        20
                  ....*....|....*....|...
gi 1590460078   2 GDWLRDIWDWVCTVLSDFKTWLS 24
Cdd:pfam01506   1 SSWLWDIWDWVCRVLRDFKNWLK 23
 
Name Accession Description Interval E-value
HCV_NS5a_1b pfam08301
Hepatitis C virus non-structural 5a domain 1b; The molecular function of the non-structural 5a ...
 96-150 5.16e-24

Hepatitis C virus non-structural 5a domain 1b; The molecular function of the non-structural 5a protein is uncertain. The NS5a protein is phosphorylated when expressed in mammalian cells. It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR. This region corresponds to the 1b domain.


Pssm-ID: 149382  Cd Length: 102  Bit Score: 89.34  E-value: 5.16e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1590460078  96 GPGTPCPSPNYTRALWRVAANSYVEVRRVGDFHYITGATEDELkCPCQVPAAEFF 150
Cdd:pfam08301   1 GPAVPLPPPNYGPALWRVGAEDYVEVVRVGDTHYVTATSCYNL-CPCQVPRPEFF 54
HCV_NS5a pfam01506
Hepatitis C virus non-structural 5a protein membrane anchor; The molecular function of the ...
 2-24 1.16e-07

Hepatitis C virus non-structural 5a protein membrane anchor; The molecular function of the non-structural 5a protein is uncertain. The NS5a protein is phosphorylated when expressed in mammalian cells. It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR. The N-terminal region of the NS5a protein has been used in the construction of the alignment for this family. The C-terminal region has not been included because it is too heterogeneous.


Pssm-ID: 366682  Cd Length: 23  Bit Score: 45.27  E-value: 1.16e-07
                          10        20
                  ....*....|....*....|...
gi 1590460078   2 GDWLRDIWDWVCTVLSDFKTWLS 24
Cdd:pfam01506   1 SSWLWDIWDWVCRVLRDFKNWLK 23
 
Name Accession Description Interval E-value
HCV_NS5a_1b pfam08301
Hepatitis C virus non-structural 5a domain 1b; The molecular function of the non-structural 5a ...
 96-150 5.16e-24

Hepatitis C virus non-structural 5a domain 1b; The molecular function of the non-structural 5a protein is uncertain. The NS5a protein is phosphorylated when expressed in mammalian cells. It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR. This region corresponds to the 1b domain.


Pssm-ID: 149382  Cd Length: 102  Bit Score: 89.34  E-value: 5.16e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1590460078  96 GPGTPCPSPNYTRALWRVAANSYVEVRRVGDFHYITGATEDELkCPCQVPAAEFF 150
Cdd:pfam08301   1 GPAVPLPPPNYGPALWRVGAEDYVEVVRVGDTHYVTATSCYNL-CPCQVPRPEFF 54
HCV_NS5a pfam01506
Hepatitis C virus non-structural 5a protein membrane anchor; The molecular function of the ...
 2-24 1.16e-07

Hepatitis C virus non-structural 5a protein membrane anchor; The molecular function of the non-structural 5a protein is uncertain. The NS5a protein is phosphorylated when expressed in mammalian cells. It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR. The N-terminal region of the NS5a protein has been used in the construction of the alignment for this family. The C-terminal region has not been included because it is too heterogeneous.


Pssm-ID: 366682  Cd Length: 23  Bit Score: 45.27  E-value: 1.16e-07
                          10        20
                  ....*....|....*....|...
gi 1590460078   2 GDWLRDIWDWVCTVLSDFKTWLS 24
Cdd:pfam01506   1 SSWLWDIWDWVCRVLRDFKNWLK 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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