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Conserved domains on  [gi|1608035411|gb|QBX07549|]
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RelE/StbE replicon stabilization toxin [Streptococcus satellite phage Javan153]

Protein Classification

type II toxin-antitoxin system RelE/ParE family toxin( domain architecture ID 10005193)

type II toxin-antitoxin (TA) system RelE/ParE family toxin is the RelE/ParE-like toxin component of a type II toxin-antitoxin system, its activity is attenuated by interaction with its cognate antitoxin

Gene Ontology:  GO:0008657|GO:0051290|GO:0042803|GO:0030541
PubMed:  20487277|26478181|20143871

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RelE COG2026
mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system [Defense ...
 2-89 2.79e-29

mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system [Defense mechanisms];


:

Pssm-ID: 441629  Cd Length: 85  Bit Score: 99.89  E-value: 2.79e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608035411  2 TYKLVVSDEVKKQLKKMDKHVglmlAKDMKKRLDGL-NNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV 80
Cdd:COG2026    1 MYKVEFTPRALKDLKKLDKKV----QKRIKKKIEELaENPRPGGKKLKGSLKGLYRLRVGDYRIIYEIDDDELVVLVLAI 76


                 ....*....
gi 1608035411 81 GHRKEIYKR 89
Cdd:COG2026   77 GHRRDVYRK 85
 
Name Accession Description Interval E-value
RelE COG2026
mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system [Defense ...
 2-89 2.79e-29

mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system [Defense mechanisms];


Pssm-ID: 441629  Cd Length: 85  Bit Score: 99.89  E-value: 2.79e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608035411  2 TYKLVVSDEVKKQLKKMDKHVglmlAKDMKKRLDGL-NNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV 80
Cdd:COG2026    1 MYKVEFTPRALKDLKKLDKKV----QKRIKKKIEELaENPRPGGKKLKGSLKGLYRLRVGDYRIIYEIDDDELVVLVLAI 76


                 ....*....
gi 1608035411 81 GHRKEIYKR 89
Cdd:COG2026   77 GHRRDVYRK 85
ParE_toxin pfam05016
ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II ...
 5-87 6.80e-12

ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.


Pssm-ID: 398610 [Multi-domain]  Cd Length: 91  Bit Score: 55.90  E-value: 6.80e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608035411  5 LVVSDEVKKQLKKMDKHV---GLMLAKDMKKRLDGL-----NNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIIL 76
Cdd:pfam05016  1 VILTPKALKDLKKIADYIaqdNPDAAERFLKALEEAlellaENPALGRPLPEGGLKGLRRIRIGDYRIIYRIDDDDLVIL 80

                         90
                 ....*....|.
gi 1608035411 77 ALEVGHRKEIY 87
Cdd:pfam05016 81 ILRVGHRRRDY 91
RelE_StbE TIGR02385
addiction module toxin, RelE/StbE family; Plasmids may be maintained stably in bacterial ...
 4-87 7.60e-07

addiction module toxin, RelE/StbE family; Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all are found adjacent to RelB/DinJ family antitoxin genes (TIGR02384), as are most genes found by the resulting model. StbE from Morganella morganii plasmid R485 shows typical behaviour for an addiction module toxin. It cannot be cloned without its partner (the antitoxin), whereas its partner cannot confer plasmid stability without StbE. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other]


Pssm-ID: 211740  Cd Length: 88  Bit Score: 42.68  E-value: 7.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608035411  4 KLVVSDEVKKQLKKMDKHVGLMLaKDMKKRLDGLNN----PRQF-GKALTGQYKGLWRYRV-GNYRVICDIVDnEMIILA 77
Cdd:TIGR02385  1 KIVYTEQFKKDLKKIKKYIRKDL-PKLLEVIELLINgkplERRYrDHPLTGSWKGTRECHIePDYLLVYQVED-EVVIRL 78

                         90
                 ....*....|
gi 1608035411 78 LEVGHRKEIY 87
Cdd:TIGR02385 79 VRVGSHSQLF 88
 
Name Accession Description Interval E-value
RelE COG2026
mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system [Defense ...
 2-89 2.79e-29

mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system [Defense mechanisms];


Pssm-ID: 441629  Cd Length: 85  Bit Score: 99.89  E-value: 2.79e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608035411  2 TYKLVVSDEVKKQLKKMDKHVglmlAKDMKKRLDGL-NNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV 80
Cdd:COG2026    1 MYKVEFTPRALKDLKKLDKKV----QKRIKKKIEELaENPRPGGKKLKGSLKGLYRLRVGDYRIIYEIDDDELVVLVLAI 76


                 ....*....
gi 1608035411 81 GHRKEIYKR 89
Cdd:COG2026   77 GHRRDVYRK 85
ParE_toxin pfam05016
ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II ...
 5-87 6.80e-12

ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.


Pssm-ID: 398610 [Multi-domain]  Cd Length: 91  Bit Score: 55.90  E-value: 6.80e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608035411  5 LVVSDEVKKQLKKMDKHV---GLMLAKDMKKRLDGL-----NNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIIL 76
Cdd:pfam05016  1 VILTPKALKDLKKIADYIaqdNPDAAERFLKALEEAlellaENPALGRPLPEGGLKGLRRIRIGDYRIIYRIDDDDLVIL 80

                         90
                 ....*....|.
gi 1608035411 77 ALEVGHRKEIY 87
Cdd:pfam05016 81 ILRVGHRRRDY 91
RelE_StbE TIGR02385
addiction module toxin, RelE/StbE family; Plasmids may be maintained stably in bacterial ...
 4-87 7.60e-07

addiction module toxin, RelE/StbE family; Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all are found adjacent to RelB/DinJ family antitoxin genes (TIGR02384), as are most genes found by the resulting model. StbE from Morganella morganii plasmid R485 shows typical behaviour for an addiction module toxin. It cannot be cloned without its partner (the antitoxin), whereas its partner cannot confer plasmid stability without StbE. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other]


Pssm-ID: 211740  Cd Length: 88  Bit Score: 42.68  E-value: 7.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608035411  4 KLVVSDEVKKQLKKMDKHVGLMLaKDMKKRLDGLNN----PRQF-GKALTGQYKGLWRYRV-GNYRVICDIVDnEMIILA 77
Cdd:TIGR02385  1 KIVYTEQFKKDLKKIKKYIRKDL-PKLLEVIELLINgkplERRYrDHPLTGSWKGTRECHIePDYLLVYQVED-EVVIRL 78

                         90
                 ....*....|
gi 1608035411 78 LEVGHRKEIY 87
Cdd:TIGR02385 79 VRVGSHSQLF 88
YafQ COG3041
mRNA-degrading endonuclease YafQ (mRNA interferase), toxin component of the YafQ-DinJ ...
 3-87 1.56e-03

mRNA-degrading endonuclease YafQ (mRNA interferase), toxin component of the YafQ-DinJ toxin-antitoxin module [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 442275  Cd Length: 88  Bit Score: 34.00  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608035411  3 YKLVVSDEVKKQLKKMdKHVGLMLAKdMKKRLDGLNNPRQFGK-----ALTGQYKGLWRYRV-GNYRVICDIVDNEMIIL 76
Cdd:COG3041    2 LKIVYTKQFKKDLKKL-KKRGPDIEK-LKKVLRLLAEGNPLPPslrdhALKGNLKGYRECHInPDWRLIYRIEDDVLILV 79

                         90
                 ....*....|.
gi 1608035411 77 AleVGHRKEIY 87
Cdd:COG3041   80 R--IGSHSELF 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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