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Conserved domains on  [gi|1610104015|gb|QBY36343|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Perca flavescens]

Protein Classification

NADH-ubiquinone oxidoreductase subunit 4L( domain architecture ID 10009576)

NADH-ubiquinone oxidoreductase subunit 4L (ND4L) is core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 3.06e-56

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177185  Cd Length: 98  Bit Score: 168.60  E-value: 3.06e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610104015  1 MTPVHFAFSSAFILGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSAAPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00126   1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                         90
                 ....*....|....*...
gi 1610104015 81 TARTHGTDRLQNLNLLQC 98
Cdd:MTH00126  81 TARTHGTDRLQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 3.06e-56

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 168.60  E-value: 3.06e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610104015  1 MTPVHFAFSSAFILGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSAAPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00126   1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                         90
                 ....*....|....*...
gi 1610104015 81 TARTHGTDRLQNLNLLQC 98
Cdd:MTH00126  81 TARTHGTDRLQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
11-98 7.36e-16

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 66.43  E-value: 7.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610104015 11 AFILGLTGLAFHRtHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSAAPMLLLAFSACEASAGLALLVATARTHGTDRL 90
Cdd:pfam00420  9 LFLIGLYGLLLRR-NLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYRTHGTDDV 87


                 ....*...
gi 1610104015 91 QNLNLLQC 98
Cdd:pfam00420 88 DSLNLLKG 95
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 1-96 1.90e-05

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 39.66  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610104015  1 MTPVHFAFSSA--FILGLTGLAFHRtHLLSALLCLEGMMLS---LFIALSLWTLQLDSTNFSaapMLLLAFSACEASAGL 75
Cdd:COG0713    1 IPLEHYLILAAilFAIGLYGVLTRR-NLIVVLMSIELMLNAvnlNLVAFSRYLGDLDGQVFA---LFVIAVAAAEVAVGL 76

                         90       100
                 ....*....|....*....|.
gi 1610104015 76 ALLVATARTHGTDRLQNLNLL 96
Cdd:COG0713   77 AIIVALYRNRGTIDVDDLNEL 97
 
Name Accession Description Interval E-value
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 3.06e-56

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 168.60  E-value: 3.06e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610104015  1 MTPVHFAFSSAFILGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSAAPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00126   1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                         90
                 ....*....|....*...
gi 1610104015 81 TARTHGTDRLQNLNLLQC 98
Cdd:MTH00126  81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.77e-41

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 131.26  E-value: 1.77e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610104015  1 MTPVHFAFSSAFILGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSAAPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00067   1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                         90
                 ....*....|....*...
gi 1610104015 81 TARTHGTDRLQNLNLLQC 98
Cdd:MTH00067  81 TTRTHGTDHLKNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 3.38e-39

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 125.73  E-value: 3.38e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610104015  1 MTPVHFAFSSAFILGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSAAPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00125   1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                         90
                 ....*....|....*...
gi 1610104015 81 TARTHGTDRLQNLNLLQC 98
Cdd:MTH00125  81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.55e-28

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 98.08  E-value: 2.55e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610104015  1 MTPVHFAFSSAFILGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSAAPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1610104015 81 TARTHGTDRLQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 5-96 3.72e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 85.00  E-value: 3.72e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610104015  5 HFAFSSAFILGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSAAPMLLLAFSACEASAGLALLVATART 84
Cdd:MTH00181   2 MFVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRT 81

                         90
                 ....*....|..
gi 1610104015 85 HGTDRLQNLNLL 96
Cdd:MTH00181  82 HGSDHLLKFNLL 93
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 2.02e-19

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 75.34  E-value: 2.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610104015  1 MTPVHFAFSSAFILGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSAAPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00043   1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                         90
                 ....*....|....*..
gi 1610104015 81 TARTHGTDRLQNLNLLQ 97
Cdd:MTH00043  81 LSRNHNSDLVASLNLLQ 97
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
11-98 7.36e-16

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 66.43  E-value: 7.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610104015 11 AFILGLTGLAFHRtHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSAAPMLLLAFSACEASAGLALLVATARTHGTDRL 90
Cdd:pfam00420  9 LFLIGLYGLLLRR-NLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYRTHGTDDV 87


                 ....*...
gi 1610104015 91 QNLNLLQC 98
Cdd:pfam00420 88 DSLNLLKG 95
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 12-98 1.47e-12

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 58.06  E-value: 1.47e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610104015 12 FILGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSAapMLLLAFSACEASAGLALLVATARTHGTDRLQ 91
Cdd:MTH00188  13 VVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEKELYLS--LVLLTFAACEASVGLALLVSLIRSHGSDYVS 90


                 ....*..
gi 1610104015 92 NLNLLQC 98
Cdd:MTH00188  91 SLNLIKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.47e-10

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 52.93  E-value: 1.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610104015  1 MTPVHFAFSSAFILGLTGLAFHRTHLLSALLCLEGMMLSLFIAL-SLWTLQLDSTNFSaapMLLLAFSACEASAGLALLV 79
Cdd:MTH00149   2 MFMLLLLSLFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMMfSSSGLISFSSYLF---LIILTFGACEASLGLSLLV 78

                         90
                 ....*....|....*....
gi 1610104015 80 ATARTHGTDRLQNLNLLQC 98
Cdd:MTH00149  79 SLIRLHGNDYVSSLSSLKF 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 12-92 6.96e-10

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 50.92  E-value: 6.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610104015 12 FILGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSaaPMLLLAFSACEASAGLALLVATARTHGTDRLQ 91
Cdd:MTH00162  11 FFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYF--LLFFLTFSVCEGALGLSILVSMIRSHGNDYFS 88


                 .
gi 1610104015 92 N 92
Cdd:MTH00162  89 S 89
ND4L MTH00180
NADH dehydrogenase subunit 4L; Provisional
 12-97 1.87e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177231  Cd Length: 99  Bit Score: 47.72  E-value: 1.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610104015 12 FILGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSAAPMLLLAFSACEASAGLALLVATARTHGTDRLQ 91
Cdd:MTH00180  13 FILGVLGIVLNRSNLIIMLMSIELMLLAISLLFLINSVAIDNLIGQIFTIMILTVAAAESAIGLAILVAYYRIRGTIAVK 92


                 ....*.
gi 1610104015 92 NLNLLQ 97
Cdd:MTH00180  93 SLNLLR 98
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 7.11e-08

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 45.90  E-value: 7.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610104015  1 MTPVHFAFSSAFILGLTGLAFHRTHLLSALLCLEGMMLSL--FIALSLWTLQLDSTNFSaapMLLLAFSACEASAGLALL 78
Cdd:MTH00013   1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLalFIPLSLMFANQVNGMLA---IVLLTFGACEASLGLSLL 77

                         90       100
                 ....*....|....*....|
gi 1610104015 79 VATARTHGTDRLQNLNLLQC 98
Cdd:MTH00013  78 VLMTRSYGNDMLKSLTSNKC 97
ND4L MTH00001
NADH dehydrogenase subunit 4L; Provisional
 12-97 1.37e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177099  Cd Length: 99  Bit Score: 40.05  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610104015 12 FILGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSAAPMLLLAFSACEASAGLALLVATARTHGTDRLQ 91
Cdd:MTH00001  13 FLLGIWGIILNRGHFIIMLVSIELVLLSTFFLFLINSIEIDLLIEQIFTIMGLTIAAAESAIGLAIMVAYYRIRGTISLK 92


                 ....*.
gi 1610104015 92 NLNLLQ 97
Cdd:MTH00001  93 SLNSLR 98
PRK05715 PRK05715
NADH-quinone oxidoreductase subunit NuoK;
1-96 1.66e-05

NADH-quinone oxidoreductase subunit NuoK;


Pssm-ID: 180218  Cd Length: 100  Bit Score: 39.78  E-value: 1.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610104015   1 MTPVHFAFSSA--FILGLTGLaFHRTHLLSALLCLEGMMLSL---FIALSLWTLQLDSTNFSaapMLLLAFSACEASAGL 75
Cdd:PRK05715    2 IPLQHYLILAAilFCIGLVGL-LLRRNAIVVLMSIELMLNAVnlnFVAFSSYLGDLDGQVFA---FFVITVAAAEAAIGL 77

                          90       100
                  ....*....|....*....|.
gi 1610104015  76 ALLVATARTHGTDRLQNLNLL 96
Cdd:PRK05715   78 AILLQLYRNRGTIDVDDLNEL 98
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 1-96 1.90e-05

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 39.66  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610104015  1 MTPVHFAFSSA--FILGLTGLAFHRtHLLSALLCLEGMMLS---LFIALSLWTLQLDSTNFSaapMLLLAFSACEASAGL 75
Cdd:COG0713    1 IPLEHYLILAAilFAIGLYGVLTRR-NLIVVLMSIELMLNAvnlNLVAFSRYLGDLDGQVFA---LFVIAVAAAEVAVGL 76

                         90       100
                 ....*....|....*....|.
gi 1610104015 76 ALLVATARTHGTDRLQNLNLL 96
Cdd:COG0713   77 AIIVALYRNRGTIDVDDLNEL 97
ND4 MTH00127
NADH dehydrogenase subunit 4; Provisional
 31-98 2.20e-04

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177186 [Multi-domain]  Cd Length: 459  Bit Score: 38.40  E-value: 2.20e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1610104015  31 LCLEGMMLSLFIALSLWTLQLDSTNfsaapmlllafSACEASAGLALLVATARTHGTDRLQNLNLLQC 98
Cdd:MTH00127  376 LMGELMIITSLFNWSPWTLALTGLG-----------TLITAGYSLYMFLMTQRGPLPDHIIALNPSHT 432
ND4L MTH00192
NADH dehydrogenase subunit 4L; Provisional
 12-97 8.91e-03

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177240  Cd Length: 99  Bit Score: 32.59  E-value: 8.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610104015 12 FILGLTGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLDSTNFSAAPMLLLAFSACEASAGLALLVATARTHGTDRLQ 91
Cdd:MTH00192  13 FTTGVSGIIINKNNIILILMSIELILLAISYLLIVYSVTLDNLLGIIFSLMVLTVAAAESAIGLAILVAYFRLTGTITIK 92


                 ....*.
gi 1610104015 92 NLNLLQ 97
Cdd:MTH00192  93 ALNLLR 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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